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Inflammatory bowel syndrome

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https://www.readbyqxmd.com/read/29453384/longitudinal-impact-of-ibs-type-symptoms-on-disease-activity-healthcare-utilization-psychological-health-and-quality-of-life-in-inflammatory-bowel-disease
#1
David J Gracie, P John Hamlin, Alexander C Ford
OBJECTIVES: The impact of irritable bowel syndrome (IBS)-type symptoms on the natural history of inflammatory bowel disease (IBD) is uncertain. We aimed to address this in a longitudinal study of secondary care patients. METHODS: Longitudinal disease activity was defined by disease flare, escalation of medical therapy, hospitalization, or intestinal resection. The number of investigations performed and clinics attended determined healthcare utilization. Psychological well-being and quality of life were assessed using validated questionnaires...
February 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29451364/the-prevalence-of-celiac-disease-in-adult-chinese-patients-with-diarrhea-predominant-irritable-bowel-syndrome-of-china-a-prospective-controlled-cohort-study
#2
Guanjun Kou, Jing Guo, Xiuli Zuo, Changqing Li, Chao Liu, Rui Ji, Han Liu, Xiao Wang, Yanqing Li
BACKGROUND: Celiac disease (CD) is a chronic inflammatory enteropathy with a symptom spectrum similar to that of irritable bowel syndrome (IBS). CD is a common, but largely undiagnosed, condition in Western countries. However, it is extremely rare among Chinese people, and few studies have evaluated its prevalence in China. OBJECTIVE: To determine the prevalence of CD in IBS patients diagnosed using the Rome III criteria in North China. METHODS: This was a single-center, prospective, controlled cohort study performed in Qilu Hospital involving 246 IBS patients and 246 healthy controls...
February 16, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29450453/the-association-of-age-with-clinical-presentation-and-comorbidities-of-pyoderma-gangrenosum
#3
Hovik J Ashchyan, Daniel C Butler, Caroline A Nelson, Megan H Noe, William G Tsiaras, Stephen J Lockwood, William D James, Robert G Micheletti, Misha Rosenbach, Arash Mostaghimi
Importance: Pyoderma gangrenosum is an inflammatory neutrophilic dermatosis. Current knowledge of this rare disease is limited owing to a lack of validated diagnostic criteria and large population studies. Objective: To evaluate the association of age with the clinical presentation and comorbidities of pyoderma gangrenosum. Design, Setting, and Participants: This was a multicenter retrospective cohort study performed at tertiary academic referral centers in urban settings...
February 14, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29447693/infectious-scarring-setting-the-trigger-for-intestinal-inflammation
#4
Andrew M F Johnson, R William DePaolo
The initiating factors that trigger inflammatory bowel disease (IBD) are poorly understood. In a recent paper, Yang et al. (2017) demonstrate that IBD-like syndrome in mice can develop as a consequence of recurrent pathogen infection. Pathogenic triggering of inflammatory disease is a re-emerging concept that has significant therapeutic implications.
February 14, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29421789/mechanism-of-action-of-stw%C3%A2-5-in-functional-dyspepsia-and-ibs-the-origin-of-multi-target
#5
Hans-Dieter Allescher, Heba Abdel-Aziz
BACKGROUND: STW 5 is a complex herbal combination preparation composed of 9 different herbal extracts. As an herbal medicinal product, this preparation is indicated for treating functional dyspepsia (FD) and irritable bowel syndrome (IBS). Its efficacy and practical applicability was demonstrated in several clinical studies. SUMMARY: Each herbal constituent of STW 5 has distinct effects on the gastrointestinal tract, and each shows activity through different mechanisms of action: among others, the single extracts have effects on nerves, smooth muscles, epithelial, and inflammatory cells...
February 8, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29416535/nutrients-mediate-intestinal-bacteria-mucosal-immune-crosstalk
#6
REVIEW
Ning Ma, Pingting Guo, Jie Zhang, Ting He, Sung Woo Kim, Guolong Zhang, Xi Ma
The intestine is the shared site of nutrient digestion, microbiota colonization and immune cell location and this geographic proximity contributes to a large extent to their interaction. The onset and development of a great many diseases, such as inflammatory bowel disease and metabolic syndrome, will be caused due to the imbalance of body immune. As competent assistants, the intestinal bacteria are also critical in disease prevention and control. Moreover, the gut commensal bacteria are essential for development and normal operation of immune system and the pathogens are also closely bound up with physiological disorders and diseases mediated by immune imbalance...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29414503/ileo-ileal-fistula-with-severe-malnutrition-caused-by-strangulated-ileus-surgery-while-preserving-ischemic-ileum-a-case-report
#7
Satoshi Nishiwada, Shinji Nakamura, Tetsuya Tanaka, Yuki Kirihataya, Daiki Nezu, Nobuhiro Sawa, Naoki Fujita, Haruka Ikegami, Atsushi Yoshimura
INTRODUCTION: Entero-enteric fistulas are rare complications that occur in patients with inflammatory bowel disease and other intestinal diseases. In this report, we present an ileo-ileal fistula accompanied by severe malnutrition caused by strangulated ileus surgery while preserving the ischemic ileum in a very elderly patient. CASE PRESENTATION: A 90-year-old woman underwent emergency surgery without bowel resection for strangulated ileus in another hospital. Minor abdominal pain and slight fever persisted after surgery...
January 27, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29413007/malnutrition-in-gastrointestinal-disorders-detection-and-nutritional-assessment
#8
REVIEW
Khursheed N Jeejeebhoy, Donald R Duerksen
All patients with significant gastrointestinal disease should be clinically assessed for protein calorie malnutrition by using the Subjective Global Assessment. Blood tests for anemia, electrolytes, calcium, phosphorus, magnesium, ferritin, vitamin B 12 , and folate should be considered for assessment of major micronutrients. Where malabsorption or inflammatory bowel disease is diagnosed, bone mineral density using dual beam x-ray absorptiometry, 25-OH vitamin D levels, and measurement of other vitamins and trace elements should be considered...
March 2018: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/29410117/best-practice-update-incorporating-psycho-gastroenterology-into-management-of-digestive-disorders
#9
REVIEW
Laurie Keefer, Olafur S Palsson, John E Pandolfino
Chronic digestive diseases including irritable bowel syndrome, gastroesophageal reflux disease and inflammatory bowel diseases cannot be disentangled from their psychological context-the substantial burden of these diseases is co-determined by symptom and disease severity and the ability of patients to cope with their symptoms without significant interruption to daily life. The growing field of psychogastroenterology focuses on the application of scientifically-based psychological principles and techniques to the alleviation of digestive symptoms...
January 31, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29408460/prevalence-of-and-factors-associated-with-fecal-incontinence-results-from-a-population-based-survey
#10
Stacy B Menees, Christopher V Almario, Brennan M R Spiegel, William D Chey
BACKGROUND & AIMS: Fecal incontinence (FI) is characterized by uncontrolled passage of solid or liquid stool. We aimed to determine the prevalence and severity of FI in a large sample of United States residents. METHODS: We recruited a representative sample of patients in October 2015 to complete the National Gastrointestinal (GI) Survey; a mobile app called MyGiHealth was used to systematically collect data on GI symptoms. FI was defined as accidental leakage of solid or liquid stool...
February 3, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29406827/pyoderma-gangrenosum-a-review-of-pathogenesis-and-treatment
#11
Christine Ahn, Deborah Negus, William Huang
Pyoderma gangrenosum (PG) is a complex neutrophilic dermatosis that can occur as an idiopathic disease, in association with systemic conditions such as inflammatory bowel disease, as part of an inherited inflammatory syndrome. It can be challenging to treat, as it occurs in a wide variety of clinical settings and there is a lack of a standardized treatment approach. The main limitations to treatment have been an incomplete understanding of the pathogenesis. However, recent advances have been made in understanding the pathogenesis of this condition, and PG is now considered an autoinflammatory disease process...
February 6, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29396128/irritable-bowel-syndrome-and-endometriosis-new-insights-for-old-diseases
#12
REVIEW
Davide Viganò, Federica Zara, Paolo Usai
Irritable bowel syndrome and endometriosis are two diseases affecting a significant part of the female population, either together or individually, with remarkable consequences in the quality of life. Several studies suggest an epidemiological association between them. Their association may not be just an epidemiological phenomenon, but the manifestation of a pathophysiological correlation, which probably generates a mutual promotion phenomenon. In particular, both clinical entities share the presence of a chronic low-grade inflammatory state at the basis of the disease persistence...
December 27, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29392360/hepatic-sinusoidal-dilatation
#13
Giuseppe Brancatelli, Alessandro Furlan, Alberto Calandra, Marco Dioguardi Burgio
Hepatic sinusoidal dilatation refers to the enlargement of the hepatic capillaries. Most of the time this condition is caused by hepatic venous outflow obstruction, which results in vascular stasis and congestion of hepatic parenchyma. In this setting, hepatic sinusoidal dilatation can be related to pericardial disease, heart failure, compression or thrombosis of the hepatic veins or inferior vena cava (i.e., Budd-Chiari syndrome) or central veins/sinusoids involvement (i.e., sinusoidal obstruction syndrome)...
February 1, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29384051/current-status-of-molecular-imaging-in-inflammatory-and-autoimmune-disorders
#14
Alberto Signore, Kelly Luz Anzola, Sveva Auletta, Michela Varani, Agnese Petitti, Marta Pacilio, Filippo Galli, Chiara Lauri
In the field of inflammation imaging, nuclear medicine techniques can be considered as a non-invasive tool to early detect pathophysiological changes I affected tissues. These changes usually occur before clinical onset of symptoms and before the development of anatomical changes, that are commonly detected by radiological procedures. This is particularly important for prognostic purposes, therapy decision making and for therapy follow-up. Here we review the current state-of-theart of nuclear medicine for diagnostic purposes in different conditions characterized by a chronic inflammation, such as vulnerable atherosclerotic plaques, vasculitides, rheumatoid arthritis, Sjogren syndrome, autoimmune thyroid diseases, inflammatory bowel diseases, Coeliac disease, Type 1 diabetes mellitus and other immunological diseases...
January 29, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29372567/review-article-the-physiological-effects-and-safety-of-peppermint-oil-and-its-efficacy-in-irritable-bowel-syndrome-and-other-functional-disorders
#15
REVIEW
B P Chumpitazi, G L Kearns, R J Shulman
BACKGROUND: Peppermint oil has been used for centuries as a treatment for gastrointestinal ailments. It has been shown to have several effects on gastrointestinal physiology relevant to clinical care and management. AIM: To review the literature on peppermint oil regarding its metabolism, effects on gastrointestinal physiology, clinical use and efficacy, and safety. METHODS: We performed a PubMed literature search using the following terms individually or in combination: peppermint, peppermint oil, pharmacokinetics, menthol, oesophagus, stomach, small intestine, gallbladder, colon, transit, dyspepsia, nausea, abdominal pain, and irritable bowel syndrome...
January 26, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29371960/modulation-of-inflammation-by-toll-like-receptor-4-nuclear-factor-kappa-b-in-diarrhea-predominant-irritable-bowel-syndrome
#16
Xing He, Li-Hong Cui, Xiao-Hui Wang, Zhi-Hui Yan, Chao Li, San-Dong Gong, Yan Zheng, Zhe Luo, Ying Wang
In order to investigate the function of toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB) signal pathways in the pathogenesis of diarrhea-predominant irritable bowel syndrome (IBS-D), IBS-D animal models were established in wistar rats challenged with acute and chronic stresses (29 days). Wistar rats without stress-challenged were used as controls. IBS-D models were randomly divided into two groups: one was treated with normal saline, another group was treated with TLR4/NF-κB inhibitor, pyrrolidine dithiocarbamate (PDTC) (50mg/kg/week) for continuous four times...
December 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/29370679/fecal-calprotectin-beyond-intestinal-organic-diseases
#17
Gian P Caviglia, Davide G Ribaldone, Chiara Rosso, Giorgio M Saracco, Marco Astegiano, Rinaldo Pellicano
Fecal calprotectin (FC) is a calcium-binding protein with antimicrobic, imunomodulatory and antiproliferative properties that is mainly found in the cytoplasm of neutrophil granulocytes. During the last decades, FC became an increasingly useful tool both for gastroenterologists and for general practitioners for distinguishing inflammatory bowel disease (IBD) from irritable bowel syndrome. FC correlates with clinical scoring systems and endoscopic lesions in IBD and is considered a reliable biomarker for the prediction of clinical relapse or remission...
January 25, 2018: Panminerva Medica
https://www.readbyqxmd.com/read/29367731/vitamin-d-status-in-irritable-bowel-syndrome-and-the-impact-of-supplementation-on-symptoms-what-do-we-know-and-what-do-we-need-to-know
#18
REVIEW
Claire E Williams, Elizabeth A Williams, Bernard M Corfe
BACKGROUND: Low vitamin D status is associated with risk of colorectal cancer and has been implicated in inflammatory bowel disease. Irritable bowel syndrome (IBS) is a chronic, relapsing, functional bowel disorder. A nascent literature suggests a role for vitamin D in IBS, but this has not been collated or critiqued. To date, seven studies have been published: four observational studies and three randomised controlled trials (RCTs). All observational studies reported that a substantial proportion of the IBS population was vitamin D deficient...
January 25, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29365221/colorectal-cancer-screening-and-surveillance-in-individuals-at-increased-risk
#19
Thad Wilkins, Danielle McMechan, Asif Talukder, Alan Herline
Individuals at increased risk of developing colorectal cancer include those with a personal or family history of advanced adenomas or colorectal cancer, a personal history of inflammatory bowel disease, or genetic polyposis syndromes. In general, these persons should undergo more frequent or earlier testing than individuals at average risk. Individuals who have a first-degree relative with colorectal cancer or advanced adenoma diagnosed before 60 years of age or two first-degree relatives diagnosed at any age should be advised to start screening colonoscopy at 40 years of age or 10 years younger than the earliest diagnosis in their family, whichever comes first...
January 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29364015/comparison-of-defecatory-function-after-laparoscopic-total-colectomy-and-ileorectal-anastomosis-versus-a-traditional-open-approach
#20
Mas Khan, D Jayne, R Saunders
Introduction Total colectomy and ileorectal anastomosis can result in significant defecatory frequency and poor bowel function. The aim of this study was to assess whether a laparoscopic approach is associated with any improvement in this regard. Methods A single institution retrospective review was undertaken of patients undergoing elective total colectomy and ileorectal anastomosis between 2000 and 2011. Those undergoing emergency surgery and paediatric surgery were excluded. The primary outcome measure was satisfactory defecatory function after surgery...
January 24, 2018: Annals of the Royal College of Surgeons of England
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