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IGF-1R

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https://www.readbyqxmd.com/read/29042933/effects-of-exogenous-growth-hormone-administration-on-dexamethasone-induced-growth-impairment-in-adolescent-male-rats
#1
Myung-Gyou Kim, Jeong-Seok Oh, Hye Kyung Kim, Kang-Hyun Leem
Growth impairment (GI) is one of the adverse effects of dexamethasone (DXM), and growth hormone (GH) has been used clinically to improve GI. The present study aimed to evaluate the manner in which DXM disturbs the growth rate of longitudinal bones, and the recovery effects of GH on DXM-induced GI in the longitudinal bones of adolescent male rats. In the first experiment, DXM (0, 0.5, 1, 2 and 5 mg/kg) was administered subcutaneously to identify a potential dose-dependent activity and calculate the median effective dose (ED50) of DXM-induced GI...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29039467/insulin-like-growth-factor-binding-protein-6-released-from-human-mesenchymal-stem-cells-confers-neuronal-protection-through-igf-1r-mediated-signaling
#2
Hyo-Jin Jeon, Jihye Park, Joo-Hyun Shin, Mi-Sook Chang
Human bone marrow‑derived mesenchymal stem cells (hMSCs) are a desirable cell source for cell‑based therapy to treat nervous system injuries due to their ability to differentiate into specific cell types. In addition to their multipotency, hMSCs render the tissue microenvironment more favorable for tissue repair by secreting various growth factors. Our previous study demonstrated that hMSCs secrete several growth factors, including several insulin‑like growth factor binding proteins (IGFBPs). Among these, IGFBP‑6 binds with high affinity and inhibits insulin growth factor‑2 (IGF‑2) to inhibit the growth of IGF‑2‑dependent tumors...
October 5, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29029433/h2o2-attenuates-igf-1r-tyrosine-phosphorylation-and-its-survival-signaling-properties-in-neuronal-cells-via-nr2b-containing-nmda-receptor
#3
Zhiwen Zeng, Dejun Wang, Uma Gaur, Liao Rifang, Haitao Wang, Wenhua Zheng
Impairment of insulin-like growth factor I (IGF-I) signaling plays an important role in the development of neurodegeneration. In the present study, we investigated the effect of H2O2 on the survival signaling of IGF-1 and its underlying mechanisms in human neuronal cells SH-SY5Y. Our results showed that IGF-1 promoted cell survival and stimulated phosphorylation of IGF-1R as well as its downstream targets like AKT and ERK1/2 in these cells. Meanwhile, these effects of IGF-1 were abolished by H2O2 at 200μM concentration which did not cause any significant toxicity to cells itself in our experiments...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29021621/protein-interaction-network-of-alternatively-spliced-nudcd1-isoforms
#4
Patrick Asselin-Mullen, Anaïs Chauvin, Marie-Line Dubois, Romain Drissi, Dominique Lévesque, François-Michel Boisvert
NudCD1, also known as CML66 or OVA66, is a protein initially identified as overexpressed in patients with chronic myelogenous leukemia. The mRNA of NudCD1 is expressed in heart and testis of normal tissues, and is overexpressed in several cancers. Previous studies have shown that the expression level of the protein correlates with tumoral phenotype, possibly interacting upstream of the Insulin Growth Factor - 1 Receptor (IGF-1R). The gene encoding the NudCD1 protein consists of 12 exons that can be alternative spliced, leading to the expression of three different isoforms...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28987875/activation-of-igf-1-receptors-and-akt-signaling-by-systemic-hyperinsulinemia-contributes-to-cardiac-hypertrophy-but-does-not-regulate-cardiac-autophagy-in-obese-diabetic-mice
#5
Karla Maria Pires, Marcio Buffolo, Christin Schaaf, J David Symons, James Cox, E Dale Abel, Craig H Selzman, Sihem Boudina
Autophagy plays an important role in the maintenance of normal heart function. However, the role of autophagy in the inulin resistant and diabetic heart is not well understood. Furthermore, the upstream signaling and the downstream targets involved in cardiac autophagy regulation during obesity and type 2 diabetes mellitus (T2DM) are not fully elucidated. The aim of this study was to measure autophagic flux and to dissect the upstream and downstream signaling involved in cardiac autophagy regulation in the hearts of obese T2DM mice...
October 5, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28980721/igf-1-signaling-mediated-cell-specific-skeletal-mechano-transduction
#6
REVIEW
Faming Tian, Yongmei Wang, Daniel D Bikle
Mechanical loading preserves bone mass and stimulates bone formation, whereas skeletal unloading leads to bone loss. In addition to osteocytes, which are considered the primary sensor of mechanical load, osteoblasts and bone specific mesenchymal stem cells also are involved. The skeletal response to mechanical signals is a complex process regulated by multiple signaling pathways including that of insulin-like growth factor-1 (IGF-1). Conditional osteocyte deletion of IGF-1 ablates the osteogenic response to mechanical loading...
October 5, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28979927/breast-cancer-risk-factors-in-relation-to-estrogen-receptor-progesterone-receptor-insulin-like-growth-factor-1-receptor-and-ki67-expression-in-normal-breast-tissue
#7
Hannah Oh, A Heather Eliassen, Andrew H Beck, Bernard Rosner, Stuart J Schnitt, Laura C Collins, James L Connolly, Laleh Montaser-Kouhsari, Walter C Willett, Rulla M Tamimi
Studies have suggested that hormone receptor and Ki67 expression in normal breast tissue are associated with subsequent breast cancer risk. We examined the associations of breast cancer risk factors with estrogen receptor (ER), progesterone receptor (PR), insulin-like growth factor-1 receptor (IGF-1R), and Ki67 expression in normal breast tissue. This analysis included 388 women with benign breast disease (ages 17-67 years) in the Nurses' Health Studies. Immunohistochemical staining was performed on tissue microarrays constructed from benign biopsies containing normal breast epithelium and scored as the percentage of epithelial cells that were positively stained...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28972962/igf-1r-associates-with-adverse-outcomes-after-radical-radiotherapy-for-prostate-cancer
#8
Tamara Aleksic, Clare Verrill, Richard J Bryant, Cheng Han, Andrew Ross Worrall, Laurent Brureau, Stephane Larré, Geoff S Higgins, Fahad Fazal, Ahmad Sabbagh, Syed Haider, Francesca M Buffa, David Cole, Valentine M Macaulay
BACKGROUND: Activated type 1 insulin-like growth factor receptors (IGF-1Rs) undergo internalisation and nuclear translocation, promoting cell survival. We previously reported that IGF-1R inhibition delays DNA damage repair, sensitising prostate cancer cells to ionising radiation. Here we tested the clinical relevance of these findings. METHODS: We assessed associations between IGF-1R and clinical outcomes by immunohistochemistry in diagnostic biopsies of 136 men treated with 55-70 Gy external beam radiotherapy for prostate cancer, comparing results with publicly available transcriptional data in surgically treated patients...
October 3, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28968951/estradiol-er%C3%AE-2-signaling-axis-confers-growth-and-migration-of-crpc-cells-through-tmprss2-etv5-gene-fusion
#9
Hogyoung Kim, Amrita Datta, Sudha Talwar, Sarmad N Saleem, Debasis Mondal, Asim B Abdel-Mageed
Estrogen receptor beta (ERβ) splice variants are implicated in prostate cancer (PC) progression; however their underlying mechanisms remain elusive. We report that non-canonical activation of estradiol (E2)-ERβ2 signaling axis primes growth, colony-forming ability and migration of the androgen receptor (AR)-null castration-resistant PC (CRPC) cells under androgen-deprived conditions (ADC). The non-classical E2-ERβ2 mediates phosphorylation and activation of Src-IGF-1R complex, which in turn triggers p65-dependent transcriptional upregulation of the androgen-regulated serine protease TMPRSS2:ETV5a/TMPRSS2:ETV5b gene fusions under ADC...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28966916/the-igf-1r-akt-pathway-determines-cell-fate-in-response-to-p53
#10
Lei Duan, Carl G Maki
p53 that is activated in response to DNA-damaging stress can induce apoptosis or either transient or permanent cell cycle arrests. Apoptosis and permanent cell cycle arrest (senescence) are bona-fide tumor suppressor mechanisms through which p53 inhibits cancer cell survival. In contrast, transient cell cycle arrests induced by p53 can increase survival by allowing cells time to repair their DNA before proceeding with cell division. Mechanisms that control the choice of response to p53 (apoptosis vs arrest) are not fully understood...
December 2016: Translational Cancer Research
https://www.readbyqxmd.com/read/28959186/rosiglitazone-exerts-an-anti-depressive-effect-in-unpredictable-chronic-mild-stress-induced-depressive-mice-by-maintaining-essential-neuron-autophagy-and-inhibiting-excessive-astrocytic-apoptosis
#11
Zhan Zhao, Ling Zhang, Xu-Dong Guo, Lu-Lu Cao, Teng-Fei Xue, Xiao-Jie Zhao, Dan-Dan Yang, Jin Yang, Juan Ji, Ji-Ye Huang, Xiu-Lan Sun
There is increasing interest in the association between depression and the development of metabolic diseases. Rosiglitazone, a therapeutic drug used to treat type 2 diabetes mellitus, has shown neuroprotective effects in patients with stroke and Alzheimer's disease. The present study was performed to evaluate the possible roles of rosiglitazone in in vivo (unpredictable chronic mild stress-induced depressive mouse model) and in vitro (corticosterone-induced cellular model) depressive models. The results showed that rosiglitazone reversed depressive behaviors in mice, as indicated by the forced swimming test and open field test...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28955980/crk-ii-silencing-down-regulates-igf-ir-and-inhibits-migration-and-invasion-of-prostate-cancer-cells
#12
Pooja Dhupkar, Huang Zhao, Kalpana Mujoo, Zhiqiang An, Ningyan Zhang
Crk (C10 regulator of kinase) adaptor proteins are highly expressed in many types of human cancers and often contribute to aggressive cancer phenotypes. Crk II, a member of CRK family, has been reported to regulate cell migration and metastasis in breast cancer cells. However, its role in other cancer types has not been reported. In this study, we investigated the molecular function of Crk II in prostate cancer (PCa) cells (CWR-22rv1) in vitro and using a mouse tumor model. Results showed that Crk II knockdown by shRNA-mediated silencing (Crk II-shRNA) in the PCa cells significantly inhibited both cancer cell migration and invasion in cell culture study...
December 2016: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28946182/insulin-growth-factor-inhibitor-as-a-potential-new-anti-schistosoma-drug-an-in-vivo-experimental-study
#13
Abeer A Elhenawy, Rehab H Ashour, Nairmen Nabih, Naglaa M Shalaby, Amr A El-Karef, Hala S Abou-El-Wafa
BACKGROUND AND OBJECTIVE: Tyrphostin "AG1024" is an insulin growth factor-1 receptor (IGF-1R) inhibitor that displayed an effect on the viability of larval and mature schistosomes in vitro. We sought to investigate the possible in vivo role of AG1024 as a potential new anti-Schistosoma drug against immature and adult stages of Schistosoma mansoni and its effect on the degree of hepatic fibrosis and insulin pathway. METHODS: The study included a control non-infected group and 5 groups of S...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28946136/the-prognostic-and-clinicopathological-significance-of-igf-1r-in-nsclc-a-meta-analysis
#14
Jun Zhao, Xuefeng Shi, Tao Wang, Chunhua Ying, Shaojun He, Yifei Chen
BACKGROUND/AIMS: Accumulating studies have reported that IGF-1R (Insulin-like growth factor-1 receptor) is aberrantly expressed in NSCLC (non-small cell lung cancer), but the role of IGF-1R in NSCLC remains controversial. The present paper assessed the precise role of IGF-1R in NSCLC. METHODS: We comprehensively searched PubMed, EMBASE, and Web of Science in March 2017. Combined HRs and ORs were used to evaluate the prognostic and clinicopathological significance of IGF-1R in NSCLC respectively...
September 22, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28944896/microrna%C3%A2-186-targets-igf%C3%A2-1r-and-exerts-tumor%C3%A2-suppressing-functions-in-glioma
#15
Jian Jiang, Weijie Wang, Dazhao Fang, Xiaodong Jin, Lianshu Ding, Xiaoyang Sun
Glioma is the most common malignant brain tumor in adults and represents one of the most aggressive and life‑threatening types of cancer in humans. Increasing studies have revealed that microRNAs are abnormally expressed in various types of human cancer, and have oncogenic or tumor suppressive roles, which depend primarily on the type of cancer. The present study aimed to investigate the expression level and effects of microRNA‑186 (miR‑186) on glioma, and its underlying molecular mechanism. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analysis was performed to detect the expression of miR‑186 in glioma tissues and cell lines...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28939861/multiplexed-exchange-paint-imaging-reveals-ligand-dependent-egfr-and-met-interactions-in-the-plasma-membrane
#16
Jeffrey L Werbin, Maier S Avendaño, Verena Becker, Ralf Jungmann, Peng Yin, Gaudenz Danuser, Peter K Sorger
Signal transduction by receptor tyrosine kinases (RTKs) involves complex ligand- and time-dependent changes in conformation and modification state. High resolution structures are available for individual receptors dimers, but less is known about receptor clusters that form in plasma membranes composed of many different RTKs with the potential to interact. We report the use of multiplexed super-resolution imaging (Exchange-PAINT) followed by mean-shift clustering and random forest analysis to measure the precise distributions of five receptor tyrosine kinases (RTKs) from the ErbB, IGF-1R and Met families in breast cancer cells...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28938449/tsh-igf-1-receptor-cross-talk-rapidly-activates-extracellular-signal-regulated-kinases-in-multiple-cell-types
#17
Christine C Krieger, Joseph D Perry, Sarah J Morgan, George J Kahaly, Marvin C Gershengorn
We previously showed that thyrotropin (TSH)/insulinlike growth factor (IGF)-1 receptor cross-talk appears to be involved in Graves' orbitopathy (GO) pathogenesis and upregulation of thyroid-specific genes in human thyrocytes. In orbital fibroblasts from GO patients, coadministration of TSH and IGF-1 induces synergistic increases in hyaluronan secretion. In human thyrocytes, TSH plus IGF-1 synergistically increased expression of the sodium-iodide symporter that appeared to involve ERK1/2 activation. However, the details of ERK1/2 activation were not known, nor was whether ERK1/2 was involved in this synergism in other cell types...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28934637/igf-system-targeted-therapy-therapeutic-opportunities-for-ovarian-cancer
#18
REVIEW
J A L Liefers-Visser, R A M Meijering, A K L Reyners, A G J van der Zee, S de Jong
The insulin-like growth factor (IGF) system comprises multiple growth factor receptors, including insulin-like growth factor 1 receptor (IGF-1R), insulin receptor (IR) -A and -B. These receptors are activated upon binding to their respective growth factor ligands, IGF-I, IGF-II and insulin, and play an important role in development, maintenance, progression, survival and chemotherapeutic response of ovarian cancer. In many pre-clinical studies anti-IGF-1R/IR targeted strategies proved effective in reducing growth of ovarian cancer models...
September 8, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28931726/impaired-insulin-igf-1-is-responsible-for-diabetic-gastroparesis-by-damaging-myenteric-cholinergic-neurons-and-interstitial-cells-of-cajal
#19
Shu Yang, Bo Wu, Haimei Sun, Tingyi Sun, Kai Han, Dandan Li, Fengqing Ji, Guoquan Zhang, Deshan Zhou
Diabetic gastroparesis is a common complication of diabetes mellitus (DM) that is characterized by decreased serum insulin and insulin-like growth factor-1 (IGF-1). Despite the fact that insulin treatment but not glycemic control potently accelerated gastric emptying in type 1 DM patients, the role of insulin/InsR and IGF-1/IGF-1R signaling in diabetic gastroparesis remains incompletely elucidated. In this study, type 1 DM mice were established and treated with insulin or Voglibose for 8 weeks. The gastric emptying was delayed from DM week 4 when the gastric InsR and IGF-1R were declined...
September 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28927111/luteolin-reduces-migration-of-human-glioblastoma-cell-lines-via-inhibition-of-the-p-igf-1r-pi3k-akt-mtor-signaling-pathway
#20
Qiang Wang, Handong Wang, Yue Jia, Hui Ding, Li Zhang, Hao Pan
Luteolin (3',4',5,7-tetrahydroxyflavone) is a common dietary flavonoid, which has been demonstrated to exert anticancer effects in multiple cancer models. However, the detailed mechanisms underlying the inhibitory effect of luteolin on glioblastoma cell metastasis remain poorly understood. The present study assessed the effects of luteolin in the U251MG and U87MG human glioblastoma cell lines. Luteolin treatment significantly inhibited glioblastoma cell migration, and this effect was associated with downregulated matrix metalloproteinase (MMP)-2, MMP-9 and upregulated tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2...
September 2017: Oncology Letters
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