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https://www.readbyqxmd.com/read/29236213/structural-probing-screening-and-structure-based-drug-repositioning-insights-into-the-identification-of-potential-cox-2-inhibitors-from-selective-coxibs
#1
Uma Devi Bommu, Kranthi Kumar Konidala, Rishika Pamanji, Suneetha Yeguvapalli
The rate-limiting enzyme cyclooxygenase-2 (COX-2) is considered as an insightful prognostic target for non-small cell lung cancer (NSCLC) therapy. Now, administration and prolonged utilization of selective COX-2 inhibitors (COXIBs) towards moderating the NSCLC has been associated with different side effects. In the present study, we focused on the structure-based drug repositioning approaches for predicting therapeutic potential de novo candidates for human COX-2. Due to discrepancies in the eminence of x-ray diffraction structures, creates a big barrier in drug discovery approach...
December 13, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/29230075/personality-predicts-mortality-risk-an-integrative-data-analysis-of-15-international-longitudinal-studies
#2
Eileen K Graham, Joshua P Rutsohn, Nicholas A Turiano, Rebecca Bendayan, Philip J Batterham, Denis Gerstorf, Mindy J Katz, Chandra A Reynolds, Emily S Sharp, Tomiko B Yoneda, Emily D Bastarache, Lorien G Elleman, Elizabeth M Zelinski, Boo Johansson, Diana Kuh, Lisa L Barnes, David A Bennett, Dorly J H Deeg, Richard B Lipton, Nancy L Pedersen, Andrea M Piccinin, Avron Spiro, Graciela Muniz-Terrera, Sherry L Willis, K Warner Schaie, Carol Roan, Pamela Herd, Scott M Hofer, Daniel K Mroczek
This study examined the Big Five personality traits as predictors of mortality risk, and smoking as a mediator of that association. Replication was built into the fabric of our design: we used a Coordinated Analysis with 15 international datasets, representing 44,094 participants. We found that high neuroticism and low conscientiousness, extraversion, and agreeableness were consistent predictors of mortality across studies. Smoking had a small mediating effect for neuroticism. Country and baseline age explained variation in effects: studies with older baseline age showed a pattern of protective effects (HR<1...
October 2017: Journal of Research in Personality
https://www.readbyqxmd.com/read/29227848/development-and-evaluation-of-an-improved-laparoscopic-myomectomy-adopting-intracapsular-rotary-cut-procedures
#3
Shi-Lin Zhong, Li-Ping Zeng, Huan Li, Rui-Fang Wu
OBJECTIVES: To develop and evaluate the efficacy and feasibility of Intracapsular Rotary-cut Procedure (IRCP) in laparoscopic myomectomy (LM). STUDY DESIGN: It is a retrospective study conducted in Peking University Shenzhen Hospital (PUSH) in Shenzhen, China. A total of 96 patients who were treated with LM because of big and moderate size of myomas in PUSH from January 2013 and December 2015 were enrolled in this study. Among them 35 were managed with IRCP -integrated LM as the study group, while the other 61 were treated with normal LM as the control group...
November 27, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29223197/an-estimation-of-a-nonlinear-dynamic-process-using-latent-class-extended-mixed-models-affect-profiles-after-terrorist-attacks
#4
Roberto Burro, Daniela Raccanello, Margherita Pasini, Margherita Brondino
Conceptualizing affect as a complex nonlinear dynamic process, we used latent class extended mixed models (LCMM) to understand whether there were unobserved groupings in a dataset including longitudinal measures. Our aim was to identify affect profiles over time in people vicariously exposed to terrorism, studying their relations with personality traits. The participants were 193 university students who completed online measures of affect during the seven days following two terrorist attacks (Paris, November 13, 2015; Brussels, March 22, 2016); Big Five personality traits; and antecedents of affect...
January 2018: Nonlinear Dynamics, Psychology, and Life Sciences
https://www.readbyqxmd.com/read/29221999/supporting-imagers-voice-a-national-training-program-in-comparative-effectiveness-research-and-big-data%C3%A2-analytics
#5
Stella K Kang, James V Rawson, Michael P Recht
Provided methodologic training, more imagers can contribute to the evidence basis on improved health outcomes and value in diagnostic imaging. The Value of Imaging Through Comparative Effectiveness Research Program was developed to provide hands-on, practical training in five core areas for comparative effectiveness and big biomedical data research: decision analysis, cost-effectiveness analysis, evidence synthesis, big data principles, and applications of big data analytics. The program's mixed format consists of web-based modules for asynchronous learning as well as in-person sessions for practical skills and group discussion...
December 5, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29206573/associations-between-health-literacy-cancer-related-knowledge-and-preventive-health-behaviors-in-community-dwelling-korean-adults
#6
Youn-Jung Son, Sun-Hee Kim, Gi Yon Kim, Heesook Son
This cross-sectional study aimed to examine the association between health literacy, cancer-related knowledge, and preventive health behaviors among community-dwelling adults in Korea. Data were collected from 542 adults aged ≥ 18 years living in five big provinces in Korea (Seoul, Gyeonggi-do, Gyeongsang-do, Chungcheong-do, and Gangwon-do). Socio-demographic and health-related characteristics were determined using structured questionnaires. Health literacy, cancer-related knowledge, and engagement in preventive health behaviors were measured using validated instruments...
December 5, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/29205282/instructor-personality-matters-for-student-evaluations-evidence-from-two-subject-areas-at-university
#7
Lisa E Kim, Carolyn MacCann
BACKGROUND: Instructors are under pressure to produce excellent outcomes in students. Although the contribution of student personality on student outcomes is well established, the contribution of instructor personality to student outcomes is largely unknown. AIM: This study examined the influence of instructor personality (as reported by both students and instructors themselves) on student educational outcomes at university. SAMPLE AND METHOD: Mathematics and psychology university students (N = 515) and their instructors (n = 45) reported their personality under the Big Five framework...
December 4, 2017: British Journal of Educational Psychology
https://www.readbyqxmd.com/read/29200327/the-big-five-health-insurers-membership-and-revenue-trends-implications-for-public-policy
#8
Cathy Schoen, Sara R Collins
The five largest US commercial health insurance companies together enroll 125 million members, or 43 percent of the country's insured population. Over the past decade these insurers have become increasingly dependent for growth and profitability on public programs, according to an analysis of corporate reports. In 2016 Medicare and Medicaid accounted for nearly 60 percent of the companies' health care revenues and 20 percent of their comprehensive plan membership. Although headlines have focused on losses in the state Marketplaces created by the Affordable Care Act (ACA), the Marketplaces represent only a small fraction of insurers' members...
December 2017: Health Affairs
https://www.readbyqxmd.com/read/29186859/peanuts-aflatoxins-and-undernutrition-in-children-in-sub-saharan-africa
#9
REVIEW
Innocent Mupunga, Pamella Mngqawa, David R Katerere
Peanuts (Arachis hypogaea) is an important and affordable source of protein in most of Sub-Saharan Africa (SSA) and a popular commodity and raw material for peanut butter, paste and cooking oil. It is a popular ingredient for foods used at the point of weaning infants from mother's milk. It is at this critical point that childhood undernutrition occurs and the condition manifests as stunting, wasting and growth restriction and accounts for nearly half of all deaths in children under five years of age in SSA...
November 26, 2017: Nutrients
https://www.readbyqxmd.com/read/29184518/proposal-allocation-ratio-as-a-moderator-of-interpersonal-responsibility-effects-on-hostile-decision-making-in-the-ultimatum-game
#10
Xinyu Gong, Ling-Xiang Xia, Yanlin Sun, Lei Guo, Vanessa C Carpenter, Yuan Fang, Yunli Chen
Interpersonal responsibility is an indigenous Chinese personality construct, which is regarded to have positive social functions. Two studies were designed to explore the relationship among interpersonal responsibility, proposal allocation ratio, and responders' hostile decisions in an ultimatum game. Study 1 was a scenario study using a hypothetical ultimatum game with a valid sample of 551 high school students. Study 2 was an experimental study which recruited 54 undergraduate students to play the incentivized ultimatum game online...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29182012/validating-online-measures-of-cognitive-ability-in-genes-for-good-a-genetic-study-of-health-and-behavior
#11
MengZhen Liu, Gianna Rea-Sandin, Johanna Foerster, Lars Fritsche, Katharine Brieger, Christopher Clark, Kevin Li, Anita Pandit, Gregory Zajac, Gonçalo R Abecasis, Scott Vrieze
Genetic association studies routinely require many thousands of participants to achieve sufficient power, yet accumulation of large well-assessed samples is costly. We describe here an effort to efficiently measure cognitive ability and personality in an online genetic study, Genes for Good. We report on the first 21,550 participants with relevant phenotypic data, 7,458 of whom have been genotyped genome-wide. Measures of crystallized and fluid intelligence reflected a two-dimensional latent ability space, with items demonstrating adequate item-level characteristics...
November 1, 2017: Assessment
https://www.readbyqxmd.com/read/29174875/insights-into-aspects-behind-internet-related-disorders-in-adolescents-the-interplay-of-personality-and-symptoms-of-adjustment-disorders
#12
Kai W Müller, Klaus Wölfling, Manfred E Beutel, Birgit Stark, Oliver Quiring, Stefan Aufenanger, Christian Schemer, Mathias Weber, Leonard Reinecke
PURPOSE: Problematic Internet use (PIU) that has recently been referred to as Internet-related disorder is a growing health concern. Yet, it is unclear why some adolescents are developing problematic use, whereas others sustain control. Based on previous research, we hypothesize that personality traits (low conscientiousness and high neuroticism) act as predispositions for PIU. We further hypothesize that PIU can be understood as a maladaptive reaction toward critical life events and that these maladaptive reactions are exacerbated by dysfunctional personality traits...
November 22, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29171511/defensive-dentistry-and-the-young-dentist-this-isn-t-what-we-signed-up-for
#13
A Al Hassan
Why did I want to become a dentist? I wanted a job where I would be respected as a professional and could change the lives of others, using my hands. This, I thought, would be my ideal profession; one where I could walk into work with a smile on my face every day. Cue dental school a place where one is trained to become competent in all areas of general dentistry. As readers will appreciate, dentistry is a vast field and the question that comes to mind is how so many diverse and varied topics can be jam packed into a five-year course...
November 24, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29171278/effects-of-sociodemographic-characteristics-and-personality-traits-on-career-development
#14
Ivana Katic, Andrea Ivanisevic, Leposava Grubic-Nesic, Nenad Penezic
The aim of this study was to identify which employees' sociodemographic characteristics and personality traits affected their career development. The research was conducted on a sample of 462 employees, aged between 30 and 55. The final analysis of covariance model included only characteristics which had previously been identified as having significant effect and relations with career development: gender, age, education level, years of work experience with the current employer, total years of work experience, financial status, and all Big Five traits...
January 1, 2017: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/29169067/the-role-of-personal-resilience-and-personality-traits-of-healthcare-students-on-their-attitudes-towards-interprofessional-collaboration
#15
Michal Avrech Bar, Michal Katz Leurer, Sigalit Warshawski, Michal Itzhaki
BACKGROUND: Interprofessional collaboration (IPC) improves communication between healthcare workers and healthcare delivery. Interprofessional education (IPE) is essential in preparing healthcare students for cooperating with other healthcare disciplines in a real work setting. Although higher education settings have a responsibility to provide collaborative healthcare practice to students, IPE has not yet been prompted worldwide as a formal division in health professional education and in Israel IPE among health professions students is scarce...
November 15, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29166225/big-five-personality-factors-and-facets-as-predictors-of-openness-to-diversity
#16
Suejung Han, M Carole Pistole
Openness to diversity is a crucial component of cultural competence needed in the increasingly diversified modern society and a necessary condition for benefitting from diversity contacts and interventions (e.g., diversity training, cultural courses). Responding to the recent call for more research on personality and its relation to diversity outcomes, we examined the associations between Big Five personality (i.e., Openness to Experience, Agreeableness, Extraversion, Neuroticism, and Conscientiousness) higher order factors and lower order facets and universal-diverse orientation (i...
November 17, 2017: Journal of Psychology
https://www.readbyqxmd.com/read/29162019/the-health-gap-doctors-and-the-social-determinants-of-health
#17
Michael Marmot
The social gradient in health has the clear implication that action to improve health and reduce inequalities has to take place at social level, not simply depending on individual changes. Individuals' ability to change is constrained by social circumstances. The evidence that the magnitude of the gradient varies between countries, and can change within a country over time, suggests that conscious strategies to change it can be successful. In my review of evidence in Britain, the Marmot Review, we made recommendations in six domains: give every child the best start in life; education and life-long learning; employment and working conditions; ensure that everyone has at least the minimum income necessary to lead a health life; healthy and sustainable places; taking a social determinants approach to prevention...
November 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29161430/methbank-3-0-a-database-of-dna-methylomes-across-a-variety-of-species
#18
Rujiao Li, Fang Liang, Mengwei Li, Dong Zou, Shixiang Sun, Yongbing Zhao, Wenming Zhao, Yiming Bao, Jingfa Xiao, Zhang Zhang
MethBank (http://bigd.big.ac.cn/methbank) is a database that integrates high-quality DNA methylomes across a variety of species and provides an interactive browser for visualization of methylation data. Here, we present an updated implementation of MethBank (version 3.0) by incorporating more DNA methylomes from multiple species and equipping with more enhanced functionalities for data annotation and more friendly web interfaces for data presentation, search and visualization. MethBank 3.0 features large-scale integration of high-quality methylomes, involving 34 consensus reference methylomes derived from a large number of human samples, 336 single-base resolution methylomes from different developmental stages and/or tissues of five plants, and 18 single-base resolution methylomes from gametes and early embryos at multiple stages of two animals...
November 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29156884/a-simple-method-of-predicting-spin-state-in-solution
#19
Santiago Rodríguez-Jiménez, Mingrui Yang, Ian Stewart, Anna L Garden, Sally Brooker
A simple method, using density functional theory (DFT), of predicting spin state in advance of synthesis is reported. Specifically, an excellent correlation is observed between the switching temperatures (T1/2) in CDCl3 solution of five spin crossover (SCO)-active [FeII(Lazine)2(NCBH3)2] complex-es and the DFT calculated (and the observed) 15N NMR chemical shift (δNA) of the five different azine-substituted 1,2,4-triazole ligands employed, Lazine = 4-(4-methylphenyl)-3-phenyl-5-(azine)-1,2,4-triazole, where azine = pyridine, pyridazine, 4-pyrimidine, pyrazine and 2-pyrimidine...
November 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29155610/seasonal-and-sexual-variation-in-metabolism-thermoregulation-and-hormones-in-the-big-brown-bat-eptesicus-fuscus
#20
Christopher S Richardson, Tim Heeren, Thomas H Kunz
In response to seasonal variation in energy availability and thermal environment, physiological and endocrine mechanisms have evolved in temperate zone animals. Seasonal changes in hormone activity affect metabolism, body temperature, and reproductive activity. We examined the seasonal regulatory role of hormones on basal metabolic rate (BMR) and regulatory nonshivering thermogenesis (RNST) in 98 female and 17 male adult Eptesicus fuscus (big brown bat). We measured BMR, RNST, and plasma levels of thyroid hormone (T3), leptin, and cortisol in bats captured in maternity colonies in eastern Massachusetts from May to August (from arousal from the hibernation phase to the prehibernation phase)...
January 2018: Physiological and Biochemical Zoology: PBZ
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