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aggressive periodontitis

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https://www.readbyqxmd.com/read/27900246/siga-peroxidase-and-collagenase-in-saliva-of-smokers-aggressive-periodontal-patients
#1
Myriam A Koss, Cecilia E Castro, Agustina M Gramajo, María E López
BACKGROUND: Tobacco smoking is strongly associated with destructive periodontal disease, alveolar bone loss and poor response to periodontal therapy. The aim of this study was to investigate the effect of smoking on antimicrobials and destructive proteins in the saliva of patients with generalized aggressive periodontal disease. MATERIAL AND METHODS: The study group consisted of 55 adult subjects. They were classified according to their clinical diagnoses either as having generalized aggressive periodontitis (n = 27; 13 smokers and 14 non-smokers) or as periodontitis-free control group (n = 28; 14 smokers and 14 non-smokers)...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27899029/treatment-compliance-in-patients-with-aggressive-periodontitis-a-retrospective-case-control-study
#2
Carolina Modin, Denise Abadji, Lottie Adler, Leif Jansson
OBJECTIVE: To investigate if differences according to discontinuation of treatment could be identified between patients with aggressive periodontitis and chronic periodontitis at two specialist clinics of periodontology irrespective of the effects of background factors. MATERIALS AND METHODS: This is a retrospective case-control study. The variables were registered from dental records. The population consisted of patients referred to two specialist clinics of periodontology during three years...
November 29, 2016: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/27886329/interleukin-8-251a-t-polymorphism-and-periodontitis-susceptibility-a-meta-analysis
#3
Z J Yang, X P Tang, Q G Lai, J B Ci, K F Yuan
The -251A/T polymorphism in the anti-inflammatory cytokine interleukin-8 (IL-8) gene has been implicated in susceptibility to periodontitis; however, this correlation has not been elucidated. In this meta-analysis, we investigated the association between the IL-8 -251A/T polymorphism and the risk of periodontitis. All eligible case-control studies published until August 2014 were identified and extracted from PubMed, Web of Science, EMBASE, China National Knowledge Internet, and WanFang databases. The strength of this association was accessed by pooled odds ratios (ORs) with 95% confidence intervals (CIs), using either a fixed- or random-effect model...
November 21, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27883202/the-role-of-platelets-in-inflammatory-immune-responses-in-generalized-aggressive-periodontitis
#4
Yalin Zhan, Ruifang Lu, Huanxin Meng, Xian'e Wang, Xiaojun Sun, Jianxia Hou
AIM: To investigate the relationship between inflammatory markers and platelet size in generalized aggressive periodontitis (GAgP). MATERIAL AND METHODS: Periodontal, inflammatory, and platelet indices were compared between 59 GAgP patients and 59 healthy subjects. Gingival biopsies from 5 patients and 5 healthy subjects were examined by immunohistochemistry and electron microscopy. Changes in patient periodontal and platelet indices were re-evaluated at 3 months after periodontal therapy...
November 24, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27834722/complete-genome-sequence-of-aggregatibacter-actinomycetemcomitans-strain-idh781
#5
Anthony C May, Rachel L Ehrlich, Sergey Balashov, Garth D Ehrlich, Mayilvahanan Shanmugam, Daniel H Fine, Narayanan Ramasubbu, Joshua Chang Mell, Carla Cugini
We report here the complete genomic sequence and methylome of Aggregatibacter actinomycetemcomitans strain IDH781. This rough strain is used extensively as a model organism to characterize localized aggressive periodontitis pathogenesis, the basic biology and oral cavity colonization of A. actinomycetemcomitans, and its interactions with other members of the oral microbiome.
November 10, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27834173/effects-of-aggregatibacter-actinomycetemcomitans-leukotoxin-on-neutrophil-migration-and-extracellular-trap-formation
#6
Josefine Hirschfeld, Helen M Roberts, Iain L C Chapple, Marijo Parčina, Søren Jepsen, Anders Johansson, Rolf Claesson
BACKGROUND: Aggressive periodontitis is associated with the presence of Aggregatibacter actinomycetemcomitans, a leukotoxin (Ltx)-producing periodontal pathogen. Ltx has the ability to lyse white blood cells including neutrophils. OBJECTIVES: This study was aimed at investigating the interactions between neutrophils and Ltx with regard to the chemotactic properties of Ltx and the release of neutrophil extracellular traps (NETs). METHODS: Neutrophils from healthy blood donors were isolated and incubated for 30 min and 3 h with increasing concentrations of Ltx (1, 10, and 100 ng/mL) as well as with A...
2016: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/27807931/esthetic-assessment-of-implants-placed-into-fresh-extraction-sockets-for-single-tooth-replacements-using-a-flapless-approach
#7
Roni Kolerman, Eitan Mijiritsky, Eitan Barnea, Areeje Dabaja, Joseph Nissan, Haim Tal
BACKGROUND: To validate the concept of immediate implant placement and nonfunctional loading for use in the esthetically sensitive anterior maxilla, clinical trials should ideally include objective esthetic criteria. PURPOSE: This study analyzed procedural results as graded by the pink esthetic score and white esthetic score (PES/WES). METHODS: Thirty-nine suitable patients (mean follow-up 44.82 ± 28 months) were evaluated. RESULTS: Thirty-eight implants fulfilled stringent criteria for successful osseointegration: absence of peri-implant radiolucency, implant mobility, suppuration, and pain...
November 2, 2016: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/27795356/mk2-signaling-shapes-macrophage-plasticity-in-aggregatibacter-actinomycetemcomitans-induced-bone-loss
#8
Bethany A Herbert, Heidi M Steinkamp, Matthias Gaestel, Keith L Kirkwood
Aggregatibacter actinomycetemcomitans is associated with aggressive periodontal disease, which is characterized by inflammation-driven alveolar bone loss. A. actinomycetemcomitans activates the p38 mitogen activated protein kinase (MAPK) and MAPK-activated protein kinase-2 (MK2) stress pathways in macrophages that are involved in host responses. During the inflammatory process in periodontal disease, chemokines are upregulated to promote recruitment of inflammatory cells. The objective of this study was to determine the role of MK2 signaling in chemokine regulation during A...
October 17, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27793851/central-odontogenic-fibromyxoma-of-mandible-an-aggressive-odontogenic-pathology
#9
Sumit Bahl, Godishala Swamy Sugunakar Raju, Gunjan Shah, Parvin Chandarana
Myxoma of the jaws which was first described by Thoma and Goldman in 1947 is a rare neoplasm and its rate of prevalence and incidence is not available. Myxoma term, according to 1992 WHO classification, is used along with odontogenic myxoma (OM) and myxofibroma. There are two forms of myxomas or fibromyxomas that are recognised in head and neck region: one is derived from the facial skeleton and the other is derived from the soft tissue. Most of the OM are located intraosseously, but peripheral ones are also recognised...
October 28, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27778470/periodontal-regeneration-in-aggressive-periodontitis-patients-a-systematic-review-of-the-literature
#10
Stefano Corbella, Roberto Weinstein, Luca Francetti, Silvio Taschieri, Massimo Del Fabbro
The aim of the present study was to systematically review the existing literature on periodontal regenerative procedures in individuals affected by aggressive periodontitis (AgP). An electronic and manual search was performed using an ad hoc prepared search string. All types of study designs were considered acceptable for inclusion. Data about treated patients, baseline clinical parameters, type of surgery, and outcomes were extracted and recorded. A narrative evaluation of the results was performed. After the article-selection process, a total of 22 full-texts were included in the qualitative synthesis...
October 25, 2016: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/27769987/human-microbiome-fusobacterium-nucleatum-in-esophageal-cancer-tissue-is-associated-with-prognosis
#11
Kensuke Yamamura, Yoshifumi Baba, Shigeki Nakagawa, Kosuke Mima, Keisuke Miyake, Kenichi Nakamura, Hiroshi Sawayama, Koichi Kinoshita, Takatsugu Ishimoto, Masaaki Iwatsuki, Yasuo Sakamoto, Yoichi Yamashita, Naoya Yoshida, Masayuki Watanabe, Hideo Baba
PURPOSE: Fusobacterium nucleatum (F. nucleatum) is a component of the human microbiome that primarily inhabits the oral cavity. It causes periodontal disease and has also been implicated in the development of human cancers. Although there are several reports of the relationship between F. nucleatum and the clinical outcome in human cancers, its prognostic significance in esophageal cancer remains unclear. EXPERIMENTAL DESIGN: We quantified F. nucleatum DNA in 325 resected esophageal cancer specimens by qPCR...
October 21, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27767222/long-term-clinical-response-to-treatment-and-maintenance-of-localized-aggressive-periodontitis-a-cohort-study
#12
Karina A F S Miller, Luciana S Branco-de-Almeida, Sandra Wolf, Nicole Hovencamp, Tina Treloar, Peter Harrison, Ikramuddin Aukhil, Yan Gong, Luciana M Shaddox
AIM: To evaluate long-term clinical response to periodontal therapy and maintenance in localized aggressive periodontitis (LAP). MATERIALS AND METHODS: One hundred forty-one African-Americans diagnosed with LAP, aged 5-25 years, were enrolled. Patients underwent periodontal mechanical debridement plus one week of amoxicillin/metronidazole. Mechanical therapy was repeated as needed and clinical parameters were recorded at baseline, 3, 6, 12, 18, and 24 months, and 2 additional annual follow-up visits after treatment...
October 21, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27755954/lack-of-association-between-the-tnf-%C3%AE-1031genotypes-and-generalized-aggressive-periodontitis-disease
#13
E Darvishi, Z Aziziaram, K Yari, M Bagheri Dehbaghi, D Kahrizi, H Karim, S Vaziri, J Zargooshi, K Ghadiri, S Muhammadi, E Kazemi, M T Moradi, M Shokrinia, N Mohammadi
Periodontal disease is one of the most prevalent inflammatory illnesses and is a main cause of tooth loss in human population. Tumor necrosis factor-α (TNF-α) gene is one of pro-inflammatory cytokines which has important role in pathogenesis of periodontal disease. The main purpose of this study is to determine genotype abundance of TNF-α-1031 gene in both groups of patients and controls, and also investigation of relation of single nucleotide polymorphism (SNP) these genotypes with periodontal disease risk...
September 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27737359/analysis-of-polymorphisms-in-interleukin-10-nos2a-and-esr2-genes-in-chronic-and-aggressive-periodontitis
#14
Virginia Régia Souza Silveira, Suzane Cristina Pigossi, Raquel Mantuaneli Scarel-Caminaga, Joni Augusto Cirelli, Rodrigo Rêgo, Nádia Accioly Pinto Nogueira
The objective of this study was to investigate the association between single nucleotide polymorphisms (SNPs) in the IL10, NOS2A, and ESR2 genes and chronic periodontitis (CP) and aggressive periodontitis (AgP). Three groups of patients underwent periodontal and radiographic evaluations: CP (n = 61), AgP (n = 50), and periodontally healthy (control group=61). Genomic DNA was extracted from oral epithelial cells and used for genotyping by real-time polymerase chain reaction using TaqMan® probes. The investigated SNPs were: -1087G > A, -819C > T and -592C > A in the IL10; +2087G > A in the NOS2A, and +1730G > A in the ESR2 gene...
October 10, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27732961/the-microbial-community-shifts-of-subgingival-plaque-in-patients-with-generalized-aggressive-periodontitis-following-non-surgical-periodontal-therapy-a-pilot-study
#15
Jing Han, Peng Wang, Shaohua Ge
The object of this study is to characterize the bacterial community of subgingival plaque of two subjects with generalized aggressive periodontitis (GAgP) pre- and post-treatment. We picked two patients with GAgP and used high-throughput 16S rDNA sequencing. V4 hypervariable region was picked for PCR amplification of subgingival samples. Then, the PCR products were sequenced through Illumina MiSeq platform. One month after therapy, both the clinical features and periodontal parameters improved obviously. Moreover, the composition and structure of subgingival bacterial community changed after initial periodontal therapy...
October 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27663105/number-of-teeth-predict-depressive-symptoms-in-a-longitudinal-study-on-patients-with-periodontal-disease
#16
Johannes C Ehrenthal, Christian Graetz, Anna Plaumann, Christof E Dörfer, Wolfgang Herzog
OBJECTIVE: Periodontal disease is associated with a wide range of psychosocial risk-factors. Disease-related tooth-loss has been associated with an increase in depressive symptoms in cross-sectional studies. However, while depression is a known risk-factor for the outcome of chronic diseases, it remains unclear if tooth loss can also predict depressive symptoms over the course of treatment. Aim of the current pilot study was to test, to what extend the number of teeth predict depressive symptoms several years later...
October 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27659091/trauma-due-to-self-aggression-in-patient-with-waardenburg-syndrome-associated-with-congenital-anomalies
#17
Sara Nader Marta, Roberto Yoshio Kawakami, Claudia Almeida Prado Piccino Sgavioli, Ana Eliza Correa, Guaniara D'Árk de Oliveira El Kadre, Ricardo Sandri Carvalho
Waardenburg syndrome (WS) is an inherited autosomal dominant genetic disorder presenting variable penetrance and expressivity, with an estimated prevalence of 1:42,000. Clinical characteristics of WS include lateral displacement of the internal eye canthus, hyperplasia of the medial portion of the eyebrows, prominent and broad nasal base, congenital deafness, pigmentation of the iris and skin, and white forelock. A 24-year-old male patient, previously diagnosed with WS, was referred to the Special Needs Dental Clinic of Sacred Heart University, Bauru, Brazil...
2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27658951/papillon-lef%C3%A3-vre-syndrome-a-series-of-five-cases-among-siblings
#18
Zyad M AIBarrak, Adel S Alqarni, Elna P Chalisserry, Sukumaran Anil
BACKGROUND: Papillon-Lefèvre syndrome is a rare autosomal recessive disorder characterized by palmoplantar hyperkeratosis and aggressively progressing periodontitis leading to premature loss of deciduous and permanent dentition. The etiopathogenesis of the syndrome is relatively obscure, and immunologic, genetic, or possible bacterial etiologies have been proposed. CASE PRESENTATION: A series of five cases of Papillon-Lefèvre syndrome among the siblings in a family is presented here: a 3-year-old Arab girl, a 4-year-old Arab boy, a 11-year-old Arab boy, a 12-year-old Arab boy, and a 14-year-old Arab boy...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27635317/identification-of-biomarkers-for-periodontal-disease-using-the-immunoproteomics-approach
#19
Jesinda P Kerishnan, Sani Mohammad, Muhamad Shaifunizam Alias, Alan Kang-Wai Mu, Rathna Devi Vaithilingam, Nor Adinar Baharuddin, Syarida H Safii, Zainal Ariff Abdul Rahman, Yu Nieng Chen, Yeng Chen
BACKGROUND: Periodontitis is one of the most common oral diseases associated with the host's immune response against periodontopathogenic infection. Failure to accurately diagnose the stage of periodontitis has limited the ability to predict disease status. Therefore, we aimed to look for reliable diagnostic markers for detection or differentiation of early stage periodontitis using the immunoprotemic approach. METHOD: In the present study, patient serum samples from four distinct stages of periodontitis (i...
2016: PeerJ
https://www.readbyqxmd.com/read/27630500/interaction-of-il1b-and-il1rn-polymorphisms-smoking-habit-gender-and-ethnicity-with-aggressive-and-chronic-periodontitis-susceptibility
#20
Magali Silveira Monteiro Ribeiro, Renata Botelho Antunes Pacheco, Ricardo Guimarães Fischer, Jacyara Maria Brito Macedo
BACKGROUND: Although the interleukin-1 (IL-1) plays a critical role in the pathogenesis of periodontitis, associations between IL1 gene cluster polymorphisms and the disease remains unclear. AIMS: To investigate the importance of IL1B-511C>T (rs16944), IL1B +3954C>T (rs1143634), and IL1RN intron 2 variable number tandem repeat (VNTR) (rs2234663) polymorphisms, individually or in combination, as the risk factors of periodontitis in a Southeastern Brazilian population with a high degree of miscegenation...
July 2016: Contemporary Clinical Dentistry
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