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aggressive periodontitis

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https://www.readbyqxmd.com/read/28427824/association-between-monocyte-chemoattractant-protein-1-2518-a-g-gene-polymorphism-and-the-outcome-of-the-nonsurgical-periodontal-treatment
#1
Ching-Wen Chang, Hsiu-Hui Lin, Shih-Yun Wu, Ching-Yi Wu, Yu-Lin Lai, Shan-Ling Hung
BACKGROUND/PURPOSE: Elevated monocyte chemoattractant protein-1 (MCP-1) is related to severe periodontal destruction. Furthermore, MCP-1 -2518 A/G gene polymorphism affects MCP-1 after inflammatory stimuli. This study analyzed the association between MCP-1 -2518 gene polymorphism and the outcome of nonsurgical periodontal treatment. METHODS: Forty periodontal patients were recruited and MCP-1 -2518 A/G gene polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism assay...
April 17, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28414081/photo-activated-elimination-of-aggregatibacter-actinomycetemcomitans-in-planktonic-culture-comparison-of-photodynamic-therapy-versus-photothermal-therapy-method
#2
Reza Fekrazad, Farzaneh Khoei, Abbas Bahador, Neda Hakimiha
BACKGROUND: Periodontal pathogens are the main factors responsible for periodontal diseases and considering the limitations of conventional mechanical debridement, new treatment approaches are under investigation. This study was designed to evaluate and compare the antibacterial effects of two different systems of photodynamic and photothermal therapy on Aggregatibacter actinomycetemcomitans as the main pathogen involved in aggressive Periodontitis. METHODS: Cultures of Aggregatibacter actinomycetemcomitans were exposed to 662nm laser in presence of Radachlorin(®) photosensitizer (photodynamic group) or 810nm laser in presence of EmunDo(®) photosensitizer (photothermal group), then bacterial suspension of each well in the study groups were diluted and subcultured on the surface of Muller-Hinton agar plates...
April 13, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28407420/dental-biofilm-infections-an-update
#3
REVIEW
Tove Larsen, Nils-Erik Fiehn
Teeth are colonized by oral bacteria from saliva containing more than 700 different bacterial species. If removed regularly, the dental biofilm mainly comprises oral streptococci and is regarded as resident microflora. But if left undisturbed, a complex biofilm containing up to 100 bacterial species at a site will build up and may eventually cause development of disease. Depending on local ecological factors, the composition of the dental biofilm may vary considerably. With access to excess carbohydrates, the dental biofilm will be dominated by mainly gram-positive carbohydrate-fermenting bacteria causing demineralization of teeth, dental caries, which may further lead to inflammation and necrosis in the pulp and periapical region, i...
April 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28404906/interleukin-1%C3%AE-rs1143627-polymorphism-with-susceptibility-to-periodontal-disease
#4
Wei Huang, Bing-Yang He, Jun Shao, Xiao-Wei Jia, Ya-Di Yuan
Association between interleukin-1 beta (IL-1β) rs1143627 polymorphism and periodontal disease susceptibility was inconsistent; hence we performed this meta-analysis to explore the precise correlation between them. The degree of association was appraised through calculating pooled odds ratio (OR) and its 95% confidence interval (CI). The databases known as PubMed, Embase, and Chinese National Knowledge Infrastructure were searched up to October 26, 2016. A total of 8 eligible case-control studies were finally included, which involved 229 aggressive periodontitis patients, 382 chronic periodontitis patients, and 555 healthy controls...
February 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28397250/the-cage-gene-sequence-as-a-diagnostic-marker-to-identify-jp2-and-non-jp2-highly-leukotoxic-aggregatibacter-actinomycetemcomitans-serotype-b-strains
#5
A Johansson, R Claesson, C Höglund Åberg, D Haubek, J Oscarsson
BACKGROUND AND OBJECTIVE: Aggregatibacter actinomycetemcomitans is involved in oral and systemic infections, and is associated with, eg aggressive forms of periodontitis and with endocarditis. The cagE gene encodes a ≈39 kDa putative exotoxin expressed by A. actinomycetemcomitans. The level of conservation of cagE, and its possible significance in periodontal disease, has not yet been thoroughly investigated. In the present study, the role of the cagE gene as a diagnostic marker has been investigated...
April 10, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28383798/survival-of-an-aggregatibacter-actinomycetemcomitans-quorum-sensing-luxs-mutant-in-the-mouths-of-rhesus-monkeys-insights-into-ecological-adaptation
#6
Senthil Kumar Velusamy, Vandana Sampathkumar, Dipti Godboley, Daniel H Fine
Experiments were designed to explore a prominent autoinducer-2 (AI-2) producing gene (luxS) related to colonization and survival of Aggregatibacter actinomycetemcomitans, a low abundance member of the indigenous flora, that forms a key component of the dysbiotic flora in localized aggressive periodontitis. The luxS gene was disrupted in a primate strain of A. actinomycetemcomitans prior to implantation into the oral cavity of Rhesus monkeys (Rh). The colonization efficiency of the luxS mutant (RhAa-VS4) was compared to the parental wild-type strain (RhAa3) (positive control) and a ltxA mutant (RhAa-VS2) (negative control)...
April 6, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/28383606/generalized-aggressive-periodontitis-microbiological-composition-and-clinical-parameters-in-non-surgical-therapy
#7
María M Usin, Sandra M Tabares, Julieta Menso, Estela R de Albera, Adela Sembaj
The aim of this study was to determine the variations in periodontal parameters and microbiological composition in periodontal pockets at the baseline and 3 and 6 months post treatmentin patients with Generalized Aggressive Periodontitis(GAP) undergoing non surgical periodontal treatment combined with chlorhexidine and systemic antibiotics. Medical and dental history was taken from 10 subjects, average age 30.6±2.7 years, diagnosed with GAP. A non surgical periodontal treatment combined with 0.12% chlorhexidine, 875 mg amoxicillin and 500 mg metronidazole every 12 hours for ten days was conducted...
December 2016: Acta Odontológica Latinoamericana: AOL
https://www.readbyqxmd.com/read/28382581/the-prominent-proteins-expressed-in-healthy-gingiva-a-pilot-exploratory-tissue-proteomics-study
#8
Emre Yaprak, Murat Kasap, Gürler Akpınar, Sibel Kayaaltı-Yüksek, Alper Sinanoğlu, Nil Guzel, Husniye Demirturk Kocasarac
Gingiva is a unique tissue which protects the underlying periodontal tissues from consistent mechanical and bacterial aggressions. Molecular analysis of gingiva is likely to improve our understanding of the underlying biological processes at work. The aim of this preliminary exploratory study is to analyze the proteomic profile of healthy gingiva and to detect prominently expressed proteins. Gingival tissue samples were obtained from periodontally healthy individuals who underwent surgical crown lengthening procedure...
April 5, 2017: Odontology
https://www.readbyqxmd.com/read/28371599/formyl-peptide-receptor-polymorphisms-27-most-possible-ways-for-phagocyte-dysfunction
#9
REVIEW
S S Skvortsov, A G Gabdoulkhakova
Formyl peptide receptors (FPRs) expressed by mammalian myeloid cells are the important part of innate immunity. They belong to the seven-transmembrane domain class of receptors coupled to heterotrimeric GTP-binding proteins. Binding of the receptor with a wide spectrum of exogenous and endogenous ligands triggers such defensive phagocyte reactions as chemotaxis, secretory degranulation, and respiratory burst, keeping a balance of inflammatory and antiinflammatory processes in the organism. The association between single nucleotide polymorphisms in the gene of FPR1 receptor resulting in disruption of the receptor structure and the development of certain pathologies accompanied with inflammation, such as aggressive periodontitis, macular degeneration, and even gastric cancer (Maney, P...
April 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28371086/immediate-implant-and-rehabilitation-based-on-all-on-4-concept-in-patients-with-generalized-aggressive-periodontitis-a-medium-term-prospective-study
#10
Sha Li, Ping Di, Yu Zhang, Ye Lin
BACKGROUND: Aggressive periodontitis renders a great challenge to the conventional implant due to the risks of infection and ongoing marginal bone loss (MBL). A study about full-arch immediate implant and restoration in patients with advanced generalized aggressive periodontitis (GAP) was not read, even though the All-on-4 concept has been proven to be predictable for edentulous patients. PURPOSE: This prospective study aimed to evaluate the feasibility and medium-term outcomes of immediate implant and rehabilitation based on the All-on-4 concept in patients with advanced GAP via clinical and radiographic analyses...
April 3, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28367890/root-abnormalities-and-nonsurgical-management-of-generalized-aggressive-periodontitis
#11
Da Lü, Huanxin Meng, Li Xu, Xian'e Wang, Li Zhang, Yu Tian
To investigate long-term nonsurgical treatment outcomes in patients with generalized aggressive periodontitis (GAgP) and the impact of root abnormalities (RAs) and other patient-level factors in relation to GAgP progression. Patients (n = 64) from a GAgP cohort who completed active nonsurgical periodontal treatment and consented to re-evaluation after 3 to 11 (mean 5.3) years, were enrolled. RAs were identified using radiographs. Periodontal parameters (e.g., probing depths [PDs], and tooth loss [TL]) were investigated...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28346706/tooth-loss-in-generalized-aggressive-periodontitis-prognostic-factors-after-17-years-of-supportive-periodontal-treatment
#12
Christian Graetz, Sonja Sälzer, Anna Plaumann, Peter Schlattmann, Maren Kahl, Claudia Springer, Christof Dörfer, Falk Schwendicke
AIM: This retrospective longitudinal study assessed the risk of and prognostic factors for tooth loss in patients with generalized aggressive periodontitis (GAgP) after periodontal treatment in a university setting. METHODS: 57 patients (1505 teeth) were examined before (T0) and after active periodontal therapy (APT, T1) as well as after 17.4±4.8 [range: 9-28] years of supportive periodontal therapy (SPT, T2). Descriptive statistics and a Cox-proportional-hazards shared-frailty model were applied...
March 27, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28299350/orthodontic-management-in-aggressive-periodontitis
#13
REVIEW
Rajesh Gyawali, Bhagabat Bhattarai
Aggressive periodontitis is a type of periodontitis with early onset and rapid progression and mostly affecting young adults who occupy a large percentage of orthodontic patients. The role of the orthodontist is important in screening the disease, making a provisional diagnosis, and referring it to a periodontist for immediate treatment. The orthodontist should be aware of the disease not only before starting the appliance therapy, but also during and after the active mechanotherapy. The orthodontic treatment plan, biomechanics, and appliance system may need to be modified to deal with the teeth having reduced periodontal support...
2017: International Scholarly Research Notices
https://www.readbyqxmd.com/read/28288871/flavan-3-ols-and-proanthocyanidins-from-limonium-brasiliense-inhibit-the-adhesion-of-porphyromonas-gingivalis-to-epithelial-host-cells-by-interaction-with-gingipains
#14
Angelo de Oliveira Caleare, Andreas Hensel, João Carlos Palazzo Mello, Andressa Blainski Pinha, Gean Pier Panizzon, Matthias Lechtenberg, Frank Petereit, Celso Vataru Nakamura
Porphyromonas gingivalis is a pathogen strongly involved in chronic and aggressive forms of periodontitis. Natural products, mainly polyphenols, have been described for advanced treatment of periodontitis by inhibition of the bacterial adhesion of P. gingivalis to the epithelial host cells. An acetone:water extract (LBE) from the rhizomes of Limonium brasiliense (Boiss.) Kuntze was tested under in vitro conditions for potential antiadhesive effects against P. gingivalis to human KB cells and for inhibition of the proteolytic activity of gingipains, the main virulence factor of P...
April 2017: Fitoterapia
https://www.readbyqxmd.com/read/28282773/association-of-periodontitis-with-preterm-birth-and-low-birth-weight-a-comprehensive-review
#15
Alberto Puertas, Antonio Magan-Fernandez, Vanessa Blanc, Laura Revelles, Francisco O'Valle, Elena Pozo, Ruben León, Francisco Mesa
It is estimated that six million perinatal deaths occur every year worldwide, with premature birth being the main cause. Scientific evidence has shown that there is an association between periodontal health during pregnancy and adverse outcomes of labor, although interventional studies based on the treatment of periodontitis have failed to document an impact on reducing the incidence of preterm birth (PB) or low birth weight (LBW). Two pathogenic mechanisms have been proposed to explain this association. The direct pathway is based on the presence of gram-negative anaerobic bacteremia originating in the gingival biofilm, whereas the indirect pathway involves the production of pro-inflammatory markers which enter the bloodstream from the gingival submucosa...
February 28, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28280638/a-giant-cell-lesion-with-cellular-cannibalism-in-the-mandible-case-report-and-review-of-brown-tumors-in-hyperparathyroidism
#16
Lorenzo Azzi, Laura Cimetti, Matteo Annoni, Diego Anselmi, Lucia Tettamanti, Angelo Tagliabue
A small radiolucent area in the mandible was discovered in a 58-year-old woman with no oral complaints. The patient's history included only hypertension. The lesion was considered as an inflammatory cyst and was enucleated. Three months later, a CT revealed the presence of a cyst-like lesion in the mandible with thin expanded buccal cortical plate, localized erosion, and a polylobate appearance on the lingual aspect of the cortical plate. The histological diagnosis of the lesion was central giant-cell granuloma (CGCG)...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28274060/comparison-of-cone-beam-computed-tomography-derived-alveolar-bone-density-between-subjects-with-and-without-aggressive-periodontitis
#17
Mohammad S Al-Zahrani, Eman Y Elfirt, Manea M Al-Ahmari, Ibrahim A Yamany, Maher A Alabdulkarim, Khalid H Zawawi
INTRODUCTION: Understanding the changes in bone density of patients affected by aggressive periodontitis could be useful in early disease detection and proper treatment planning. AIM: The aim of this study was to compare alveolar bone density in patients affected with aggressive periodontitis and periodontally healthy individuals using Cone Beam Computed Tomography (CBCT). MATERIALS AND METHODS: This cross-sectional study was conducted on 20 patients with a confirmed diagnosis of aggressive periodontitis...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28258710/implants-placed-in-patients-with-a-history-of-aggressive-periodontitis-had-high-survival-rates-and-low-marginal-bone%C3%A2-loss
#18
Romina Brignardello-Petersen
No abstract text is available yet for this article.
March 1, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28231622/gingival-crevicular-fluid-levels-of-monocyte-chemoattractant-protein-1-in-patients-with-aggressive-periodontitis
#19
S Gunpinar, N O Alptekin, N Dundar
OBJECTIVES: The purpose of this study was to investigate the gingival crevicular fluid (GCF) levels of monocyte chemoattractant protein (MCP)-1 in aggressive periodontitis (AgP) and whether GCF MCP-1 levels differ among localized (L) AgP and generalized (G) AgP. MATERIAL AND METHODS: A total of 160 subjects including 80 AgP and 80 age- and gender-matched periodontally healthy (H) controls were recruited in this cross-sectional study (NCT02927704). GCF samples were collected from 160 patients including 50 LAgP, 30 GAgP, and 80 H...
February 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28221099/sphingomyelin-phosphodiesterase-3-enhances-cytodifferentiation-of-periodontal-ligament-cells
#20
S Miyauchi, J Kitagaki, R Masumoto, A Imai, K Kobayashi, A Nakaya, S Kawai, C Fujihara, Y Asano, M Yamashita, M Yanagita, S Yamada, M Kitamura, S Murakami
Sphingomyelin phosphodiesterase 3 ( Smpd3), which encodes neutral sphingomyelinase 2 (nSMase2), is a key molecule for skeletal development as well as for the cytodifferentiation of odontoblasts and alveolar bone. However, the effects of nSMase2 on the cytodifferentiation of periodontal ligament (PDL) cells are still unclear. In this study, the authors analyzed the effects of Smpd3 on the cytodifferentiation of human PDL (HPDL) cells. The authors found that Smpd3 increases the mRNA expression of calcification-related genes, such as alkaline phosphatase (ALPase), type I collagen, osteopontin, Osterix (Osx), and runt-related transcription factor (Runx)-2 in HPDL cells...
March 2017: Journal of Dental Research
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