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aggressive periodontitis

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https://www.readbyqxmd.com/read/28231622/gingival-crevicular-fluid-levels-of-monocyte-chemoattractant-protein-mcp-1-in-patients-with-aggressive-periodontitis
#1
Sadiye Gunpinar, Nilgun Ozlem Alptekin, Niyazi Dundar
OBJECTIVES: The purpose of this study was to investigate the gingival crevicular fluid (GCF) levels of Monocyte Chemoattractant Protein (MCP)-1 in aggressive periodontitis (AgP) and whether GCF MCP-1 levels differ among localized (L) AgP and generalized (G) AgP. MATERIAL AND METHODS: A total of 160 subjects including, 80 AgP and 80 age and gender matched periodontally healthy (H) controls were recruited in this cross-sectional study (NCT02927704). GCF samples were collected from 160 patients including 50 LAgP, 30 GAgP and 80 H...
February 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28221099/sphingomyelin-phosphodiesterase-3-enhances-cytodifferentiation-of-periodontal-ligament-cells
#2
S Miyauchi, J Kitagaki, R Masumoto, A Imai, K Kobayashi, A Nakaya, S Kawai, C Fujihara, Y Asano, M Yamashita, M Yanagita, S Yamada, M Kitamura, S Murakami
Sphingomyelin phosphodiesterase 3 ( Smpd3), which encodes neutral sphingomyelinase 2 (nSMase2), is a key molecule for skeletal development as well as for the cytodifferentiation of odontoblasts and alveolar bone. However, the effects of nSMase2 on the cytodifferentiation of periodontal ligament (PDL) cells are still unclear. In this study, the authors analyzed the effects of Smpd3 on the cytodifferentiation of human PDL (HPDL) cells. The authors found that Smpd3 increases the mRNA expression of calcification-related genes, such as alkaline phosphatase (ALPase), type I collagen, osteopontin, Osterix (Osx), and runt-related transcription factor (Runx)-2 in HPDL cells...
March 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28216095/real-time-quantitative-reverse-transcription-pcr-analysis-of-expression-stability-of-aggregatibacter-actinomycetemcomitans-fimbria-associated-gene-in-response-to-photodynamic-therapy
#3
Maryam Pourhajibagher, Abbas Monzavi, Nasim Chiniforush, Mohammad Moein Monzavi, Shaghayegh Sobhani, Sima Shahabi, Abbas Bahador
BACKGROUND: Aggregatibacter actinomycetemcomitans is an etiological agent of both chronic and aggressive periodontitis. Dissemination of A. actinomycetemcomitans from the oral cavity and initiation of systemic infections has led to new approaches for treatment being needed. In this study, a series of experiments presented investigated the effect of methylene blue (MB)-mediated antimicrobial photodynamic therapy (aPDT) on cell viability and expression of fimbria-associated gene (rcpA) in A...
February 16, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28203005/-clinical-evaluation-of-periodontal-orthodontic-treatment-in-patients-with-aggressive-periodontitis-and-malocclusion
#4
X Shen, J Shi, L Xu, J Jiao, R F Lu, H X Meng
OBJECTIVE: To evaluate the clinical effect and safety of periodontal-orthodontic treatment in patients with aggressive periodontitis (AgP) and malocclusion. METHODS: A retrospective analysis was conducted in 25 AgP patients, who had received periodontal-orthodontic treatment in Peking University School and Hospital of Stomatology. Clinical indexes, including probing depth (PD), bleeding index (BI) and percentage of sites with bleeding on probing (BOP%) were evaluated at three time points: Baseline (T0); active periodontal treatment finished and before orthodontic treatment (T1); and after orthodontic treatment (T2)...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28196160/clinical-efficacy-of-subgingivally-delivered-1-2-mg-simvastatin-in-the-treatment-of-patients-with-aggressive-periodontitis-a-randomized-controlled-clinical-trial
#5
Priyanka N, A Abhilash, Shahab Saquib, Nikhil Malgaonkar, Nitin Kudyar, Aashima Gupta, Nitish Kalra, A R Pradeep
Simvastatin (SMV) is a specific competitive inhibitor of 3-hydroxy-2-methylglutaryl coenzyme A reductase that promotes bone formation. The present clinical trial was designed to investigate the effectiveness of 1.2 mg SMV as a local drug delivery system and as an adjunct to scaling and root planing (SRP) in the treatment of aggressive periodontitis (AgP). A total of 68 intrabony defects from 24 patients with AgP were treated either with 1.2 mg SMV gel or placebo gel. The subjects were randomly assigned to SRP + placebo (group 1; n = 12) or SRP + SMV (group 2; n = 12)...
March 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28181073/erratum-to-outcomes-of-implant-therapy-in-patients-with-a-history-of-aggressive-periodontitis-a-systematic-review-and-meta-analysis
#6
Charis Theodoridis, Andreas Grigoriadis, Georgios Menexes, Ioannis Vouros
No abstract text is available yet for this article.
February 9, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28178139/epstein-barr-virus-is-associated-with-periodontal-diseases-a-meta-analysis-based-on-21-case-control-studies
#7
Zilong Gao, Juan Lv, Min Wang
Some controversies still exist between the detection of Epstein-Barr virus (EBV)'s DNA and risks of periodontal diseases. Hence, a comprehensive meta-analysis on all available literatures was performed to clarify the relationship between EBV and preidontitis.A comprehensive search was conducted within the PUBMED, EMBASE, and WANFANG databases up to October 10th, 2016 according to inclusion and exclusion criteria and finally 21 case-control literatures were obtained. The outcomes including odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28133644/aggressive-periodontitis-the-unsolved-mystery
#8
Danielle Clark, Maria Febbraio, Liran Levin
Aggressive periodontal disease is an oral health mystery. Our current understanding of this disease is that specific bacteria invade the oral cavity and the host reacts with an inflammatory response leading to mass destruction of the alveolar bone. Aggressive periodontal disease is typically observed in a population under the age of 30 and occurs so rapidly that it is difficult to treat. Unfortunately, the consequence of this disease frequently involves tooth extractions. As a result, the aftermath is chewing disability and damage to self-esteem due to an altered self-image...
2017: Quintessence International
https://www.readbyqxmd.com/read/28105737/the-effects-of-power-toothbrushing-on-periodontal-inflammation-in-a-canadian-nursing-home-population-a-randomized-controlled-trial
#9
S E Lavigne, M B Doupe, A M Iacopino, S Mahmud, L Elliott
OBJECTIVES: The aim of this study was to investigate whether twice-daily use of a rotating-oscillating power toothbrush (Oral-B Professional Care 1000(™) ) in nursing home (NH) residents over a 6-week period, compared to usual care (UC), would reduce periodontal inflammation. METHODS: In this repeated measures single-blinded randomized controlled trial, 59 residents of one NH in Winnipeg, Canada, were randomized to receive either twice-daily tooth brushing with a rotating-oscillating power toothbrush (PB) or UC by caregivers...
January 19, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28099578/il-6-and-il-10-gene-polymorphisms-in-patients-with-aggressive-periodontitis-effects-on-gcf-serum-and-clinic-parameters
#10
Emine Pirim Gorgun, Hulya Toker, Ertan Mahir Korkmaz, Omer Poyraz
Genetic variations observed in cytokines affect periodontitis susceptibility. The aim of this study was to investigate interleukin(IL)-6(-174) and IL-10(-597) gene polymorphisms in generalized aggressive periodontitis (GAgP) patients. Also, we aimed to evaluate the effects of IL-6 and IL-10 gene polymorphisms on the clinical outcomes of non-surgical periodontal therapy and cytokine levels in gingival crevicular fluid(GCF) and serum. Fifty-three patients with GAgP and 50 periodontally healthy individuals were included in this study...
January 16, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28091448/oro-dental-characteristics-of-three-siblings-with-papillon-lefevre-syndrome
#11
O E Gungor, H Karayilmaz, H Yalcin, M Hatipoğlu
Papillon-Lefevre syndrome (PLS) is a rare autosomal recessive disorder, showing oral and dermatological manifestations in the form of aggressive periodontitis, leading to the premature loss of both primary and permanent teeth at a very young age and palmar-plantar hyperkeratosis. It was first described by two French physicians, Papillon and Lefevre in 1924. Immunologic, genetic, or possible bacterial etiologies have been thought to account for etiopathogenesis of PLS. Severe gingival inflammation and periodontal destruction occurred after the eruption of primary teeth...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28068272/surgical-resolution-of-an-aggressive-iatrogenic-root-perforation-in-a-maxillary-central-incisor-a-case-report-with-a-4-year-follow-up
#12
Ricardo Machado, Marcelo Agnoletto, Eduardo Donato Eing Engelke Back, Luiz Fernando Tomazinho, Fabricio Abel Paganini, Luiz Pascoal Vansan
The prognosis of teeth with root perforations depends on several factors, including size, location, and time since occurrence. Root perforations are clinical situations that can be solved by either nonsurgical or surgical approaches. The purpose of this article is to present a case of an aggressive iatrogenic root perforation in a maxillary right central incisor solved surgically using mineral trioxide aggregate (MTA). Even in an unfavorable situation, MTA was able to induce new bone formation and reestablish gingival and periodontal health, as confirmed in follow-up examinations at 2 and 4 years...
January 2017: General Dentistry
https://www.readbyqxmd.com/read/28050585/dataset-of-the-proteome-of-purified-outer-membrane-vesicles-from-the-human-pathogen-aggregatibacter-actinomycetemcomintans
#13
Thomas Kieselbach, Jan Oscarsson
The Gram-negative bacterium Aggregatibacter actinomycetemcomitans is an oral and systemic pathogen, which is linked to aggressive forms of periodontitis and can be associated with endocarditis. The outer membrane vesicles (OMVs) of this species contain effector proteins such as cytolethal distending toxin (CDT) and leukotoxin (LtxA), which they can deliver into human host cells. The OMVs can also activate innate immunity through NOD1- and NOD2-active pathogen-associated molecular patterns. This dataset provides a proteome of highly purified OMVs from A...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/28018430/gc-gene-polymorphisms-and-vitamin-d-binding-protein-levels-are-related-to-the-risk-of-generalized-aggressive-periodontitis
#14
Wenli Song, Xian'e Wang, Yu Tian, Xin Zhang, Ruifang Lu, Huanxin Meng
Objective. To explore whether GC (group-specific component) rs17467825, rs4588, and rs7041 polymorphisms are associated with generalized aggressive periodontitis. Methods. This case-control study recruited 372 patients with generalized aggressive periodontitis (group AgP) and 133 periodontal healthy subjects (group HP). GC rs17467825, rs4588, and rs7041 genotypes and plasmatic vitamin D-binding protein (DBP) were measured. Analysis of single SNP and multiple SNPs was performed and relevance between plasmatic DBP and haplotypes was analyzed...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28013554/the-emerging-roles-of-b-cells-as-partners-and-targets-in-periodontitis
#15
Moncef Zouali
Initial studies of periodontal disease suggested that T cell-mediated immunity against oral Gram-negative microorganisms is a key player in the pathogenesis of this inflammatory disease. Recent investigations, however, revealed that B cells are also engaged. Given their chief role in innate-like and adaptive immune responses, B cells could exert protective functions in periodontitis. However, the periodontal bacteria-specific antibody response is generally unable to halt disease progression in affected subjects, suggesting that the antibodies produced could exhibit low anti-bacterial blocking functions or opsonophagocytic potential, and/or unfavorable effects...
December 26, 2016: Autoimmunity
https://www.readbyqxmd.com/read/28013438/outcomes-of-implant-therapy-in-patients-with-a-history-of-aggressive-periodontitis-a-systematic-review-and-meta-analysis
#16
REVIEW
Charis Theodoridis, Andreas Grigoriadis, Georgios Menexes, Ioannis Vouros
OBJECTIVE: To investigate the outcomes of implant therapy in partially dentate patients treated for aggressive periodontitis (GAgP) in comparison to periodontally healthy (HP) and patients treated for chronic periodontitis (CP) utilizing radiographic and clinical parameters. MATERIAL AND METHODS: An electronic search of databases, supplemented by hand searching, was conducted to identify relevant clinical studies. Sequential screenings at the title, abstract and full-text levels were performed independently and in duplicate...
December 24, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28008419/trends-in-susceptibility-to-aggressive-periodontal-disease
#17
Nishat Shahabuddin, Kathleen Boesze-Battaglia, Edward T Lally
Aggregatibacter actinomycetemcomitans is a gram-negative microbe involved in periodontitis. Strains with varying degrees of virulence have been identified, in healthy and periodontally compromised individuals alike. Hosts mount differential immune responses to its various serotypes and virulence factors. Studies have explored host immune response in terms of antibody titers, leukocyte responses, and specific inflammatory mediators, questioning the ways in which the infectious microorganism survives. This mini-review will identify the key themes in immune response patterns of individuals both affected by and free from aggressive periodontal disease, thereby using it to understand various forms of periodontitis...
2016: Int J Dent Oral Health
https://www.readbyqxmd.com/read/27994415/detection-of-porphyromonas-gingivalis-and-treponema-denticola-in-chronic-and-aggressive-periodontitis-patients-a-comparative-polymerase-chain-reaction-study
#18
Ramniwas M Kumawat, Sindhu M Ganvir, Vinay K Hazarey, Asifa Qureshi, Hemant J Purohit
BACKGROUND: The detection frequency of Porphyromonas gingivalis and Treponema denticola in chronic periodontitis (CP) and aggressive periodontitis (AgP) is not explored well in Indian population. AIM: The study was undertaken to detect P. gingivalis and T. denticola in CP as well as in AgP patients using polymerase chain reaction (PCR), and to determine the relationship between the frequency of these two microorganisms and the severity of clinical periodontal parameters...
October 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27980332/antibiotics-in-aggressive-periodontitis-is-there-a-clinical-benefit
#19
Anjana Rajendra, Silvia Spivakovsky
Data sourcesMedline, Embase and CENTRAL databases were searched up to December 2014. Unpublished data were sought by searching a database listing unpublished studies OpenGray [http://www.opengrey.eu/], formerly OpenSIGLE.Study selectionRandomised clinical trials assessing treatment of patients with AgP comparing scaling and root planing (SRP) alone with SRP plus a single antibiotic or a combination of drugs with a minimum of three months follow-up were considered. Studies specifically designed to evaluate smokers or subjects with diabetes mellitus and HIV/AIDS were not included...
December 2016: Evidence-based Dentistry
https://www.readbyqxmd.com/read/27932832/should-implants-be-considered-for-patients-with-periodontal-disease
#20
E King, R Patel, A Patel, L Addy
Dental implants are seen as a good option for replacing missing teeth. The success and survival rates for implants are very high. Concerns are developing about the problem of peri-implantitis. The reports of its prevalence vary but it is noted that the presence of periodontal disease is a risk factor. The issue of peri-implantitis was raised in the House of Lords in 2014. Complaints relating to implants is on the rise with the General Dental Council. Placement of implants in patients with periodontal disease is not a treatment that should be done without a full periodontal assessment and stabilisation of periodontal disease first...
December 9, 2016: British Dental Journal
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