Silvia Diz De Almeida, Gesa M Richter, Alicia de Coo, Søren Jepsen, Ines Kapferer-Seebacher, Henrik Dommisch, Klaus Berger, Matthias Laudes, Wolfgang Lieb, Bruno G Loos, Nathalie van der Velde, Natasja van Schoor, Lisette de Groot, Juan Blanco, Angel Carracedo, Raquel Cruz, Arne S Schaefer
AIM: Few genome-wide association studies (GWAS) have been conducted for severe forms of periodontitis (stage III/IV grade C), and the number of known risk genes is scarce. To identify further genetic risk variants to improve the understanding of the disease aetiology, a GWAS meta-analysis in cases with a diagnosis at ≤35 years of age was performed. MATERIALS AND METHODS: Genotypes from German, Dutch and Spanish GWAS studies of III/IV-C periodontitis diagnosed at age ≤35 years were imputed using TopMed...
December 23, 2023: Journal of Clinical Periodontology