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aggressive periodontitis

Danielle K Burgess, Hong Huang, Peter Harrison, Theodora Kompotiati, Ikramuddin Aukhil, Luciana M Shaddox
BACKGROUND: Previous studies have provided substantial evidence on the association of Aggregatibacter actinomycetemcomitans (Aa), and its highly leukotoxic JP2 genotype, with localized aggressive periodontitis (LAP). The present study aims to evaluate the presence of JP2 in LAP individuals following periodontal treatment. METHODS: Sixty African American LAP patients between ages 5 and 25 years were examined. At baseline, pocket depth (PD), clinical attachment level (CAL), bleeding on probing (BoP) and plaque index were measured and subgingival plaque was collected from both LAP diseased sites and healthy sites for each participant...
August 18, 2017: Journal of Periodontology
Pavan Bajaj, Esha Agarwal, Nishanth S Rao, Savitha B Naik, A R Pradeep, Nitish Kalra, N Priyanka, Minal Kumari
BACKGROUND: Platelet rich fibrin (PRF), has recently found its application in osseous regeneration. The aim of present study is to explore the efficacy of PRF in treatment of intrabony defects in aggressive periodontitis. MATERIAL AND METHODS: 54 intrabony defects in 17 patients were treated either with autologous PRF with open flap debridement (OFD) or OFD alone. Clinical and radiological parameters such as probing depth (PD), clinical attachment level (CAL), intrabony defect depth and % defect change were recorded at baseline and 9 months postoperatively...
August 18, 2017: Journal of Periodontology
Eugénia Cunha, Catarina Leal, Miguel Munhós, Isabel Poiares Baptista
We here report the discovery of a gold dental ligature from the late 15(th) century, at the Convent of Santa Clara-a-Velha, in the city of Coimbra, Portugal. A medieval Clare's nun presented the left upper lateral incisor splinted to the canine, since the others three incisors were lost, most probably due to an aggressive periodontal disease. The convent is associated with the medieval upper class, which was well known for its consumption of high levels of sugar. There is a higher prevalence of caries in comparison to other Portuguese skeletal samples of the same time period, as well as a high prevalence of periodontal disease...
August 17, 2017: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
Y Li, L Xu, Y H Zhou, X Y Ouyang, T Cao
It is complicated to decide the treatment plan of hopeless anterior teeth in esthetic zone due to severe periodontitis, periodontal-endodontic combined lesion or teeth trauma. The optional treatment plan for this kind of teeth includes retention after periodontal treatment, extraction and implant treatment, extraction and prosthodontic treatment and so on. To make an appropriate treatment plan, patients' periodontal conditions, periodontal biotype, local anatomy, esthetic demand, economic condition and social psychological status should be comprehensively considered...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Denis F Kinane, Panagiota G Stathopoulou, Panos N Papapanou
Periodontal diseases comprise a wide range of inflammatory conditions that affect the supporting structures of the teeth (the gingiva, bone and periodontal ligament), which could lead to tooth loss and contribute to systemic inflammation. Chronic periodontitis predominantly affects adults, but aggressive periodontitis may occasionally occur in children. Periodontal disease initiation and propagation is through a dysbiosis of the commensal oral microbiota (dental plaque), which then interacts with the immune defences of the host, leading to inflammation and disease...
June 22, 2017: Nature Reviews. Disease Primers
Beral Afacan, Veli Özgen Öztürk, Gülnur Emingil, Timur Köse, Nagihan Bostanci
BACKGROUND: Trappin-2 is one of the potent biologically active serine protease inhibitor with anti-inflammatory properties that has also been characterized as an "alarm anti-protease". Despite the importance of Trappin-2 in several chronic infections has been demonstrated, its potential involvement in periodontitis remains undefined. This study aimed to investigate the salivary level of Trappin-2 and interleukin-1β (IL-1β) in periodontally healthy indivudals and patients with gingivitis or generalized chronic periodontitis (CP) or aggressive periodontitis (G-AgP)...
August 4, 2017: Journal of Periodontology
Magda Feres, Yoram Louzoun, Simi Haber, Marcelo Faveri, Luciene C Figueiredo, Liran Levin
BACKGROUND: The existence of specific microbial profiles for different periodontal conditions is still a matter of debate. The aim of this study was to test the hypothesis that 40 bacterial species could be used to classify patients, utilising machine learning, into generalised chronic periodontitis (ChP), generalised aggressive periodontitis (AgP) and periodontal health (PH). METHOD: Subgingival biofilm samples were collected from patients with AgP, ChP and PH and analysed for their content of 40 bacterial species using checkerboard DNA-DNA hybridisation...
August 2, 2017: International Dental Journal
Panos N Papapanou, Cristiano Susin
Currently, two principal forms of destructive periodontal disease are recognized - chronic periodontitis and aggressive periodontitis - but their distinction in epidemiologic studies has been rather problematic because of substantial overlap of their primary features. This review critically appraises some key features relevant to the epidemiology of human periodontitis that underlie its core 'identity' as a bacterial biofilm-induced, inflammatory disease and discusses its impact within the larger context of aging populations...
October 2017: Periodontology 2000
Ubele Van der Velden
At the International Workshop for Classification of Periodontal Diseases and Conditions in 1999, the classification of aggressive and chronic periodontitis that is presently used was introduced. A literature review of papers published in 2015 and having aggressive periodontitis in the title revealed that most studies use this terminology but it is questionable whether all established criteria were really applied correctly. Review of the literature showed no qualitative differences between aggressive and chronic periodontitis regarding bacterial and viral aspects...
October 2017: Periodontology 2000
Ronaldo Lira-Junior, Veli Özgen Öztürk, Gulnur Emingil, Nagihan Bostanci, Elisabeth Almer Boström
BACKGROUND: Host inflammatory and immune responses play an important role in aggressive periodontitis (AgP). Thus, this study aimed to evaluate the levels of the innate immunity-related markers calprotectin, colony-stimulating factor (CSF)-1, macrophage migration inhibitory factor (MIF), monokine induced by interferon-γ (MIG), and matrix metalloproteinase (MMP)-8 in serum and saliva from patients having generalized AgP and those having gingivitis or a healthy periodontium. METHODS: This study enrolled 40 individuals (23 females; mean age 33...
July 28, 2017: Journal of Periodontology
Pınar Gümüş, Nejat Nizam, Ayşe Nalbantsoy, Özgün Özçaka, Nurcan Buduneli
PURPOSE: This cross-sectional study aims to evaluate saliva, serum levels of interleukin-21 (IL-21), IL-33, and prostaglandin E2 (PGE2) in patients with generalised chronic periodontitis or aggressive periodontitis. MATERIALS AND METHODS: Before initiation of any periodontal treatment, saliva and serum samples were collected and clinical periodontal measurements were recorded from 94 participants (25 aggressive periodontitis patients, 25 chronic periodontitis patients, 44 periodontally healthy individuals)...
July 27, 2017: Oral Health & Preventive Dentistry
I M Velsko, Y Cruz-Almeida, H Huang, S M Wallet, L M Shaddox
Localized aggressive periodontitis (LAP) is a rare form of periodontal disease with site-specific rapid tissue destruction. A lipopolysaccharide (LPS) hyper-inflammatory response was shown in LAP using peripheral whole blood, although responses to other bacterial surface components or complex oral biofilms have not been evaluated. Peripheral blood mononuclear cells (PBMCs) from 14 LAP patients, 15 healthy siblings (HS), and 13 unrelated healthy controls (HC) were stimulated with: LPS, lipoteichoic acid, or peptidoglycan; intact or sonically dispersed in vitro-grown biofilms from a LAP disease site, a LAP healthy site, or a healthy control site...
2017: Journal of Oral Microbiology
Chih-Chin Liu, Chang-Hua Chen, Chuan Yi Tang, Kuan-Hsueh Chen, Zhao-Feng Chen, Shih-Hao Chang, Chi-Ying Tsai, Ming-Li Liou
BACKGROUD/PURPOSE: Aggregatibacter actinomycetemcomitans has emerged as one of the aetiological agents in periodontal disease. Although Type IV secretion systems (T4SSs) are widely distributed in many bacteria, the genetic features and distribution of T4SSs in A. actinomycetemcomitans remain unclear. In this study, we investigated the prevalence of A. actinomycetemcomitans serotypes and their T4SSs in a Taiwanese population. METHODS: A comparative analysis of 20 A...
June 30, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
Nishi Singh, Siddhartha Chandel, Harmurti Singh, Amiya Agrawal, A N Savitha
INTRODUCTION: Host response and environmental factors are known to modify periodontal status adversely. Presently serum, saliva, and GCF are being investigated for its biochemical constituents. GCF contains array of biochemical factors, offering potential use as a diagnostic or prognostic biomarker of the biologic state of the periodontium in health and disease. Alkaline phosphatase is produced locally in the periodontium and shows positive correlation with disease activity and PD. Present study was designed to analyze the levels of ALP in GCF and serum of patients with gingivitis, chronic & aggressive periodontitis before and after SRP & to compare the difference within the study groups...
May 2017: Journal of Oral Biology and Craniofacial Research
Diana M Isaza-Guzmán, Verónica M Medina-Piedrahíta, Carolina Gutiérrez-Henao, Sergio I Tobón-Arroyave
BACKGROUND: Emerging evidence suggests that the activation of inflammasomes plays a central mechanism in the pathogenesis of periodontitis. This study aimed to compare the salivary levels of nod-like receptor family pyrin domain containing protein 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), cysteine aspartase-1 (caspase-1), and interleukin-1 beta (IL-1β) from individuals with aggressive (AgP) or chronic periodontitis (CP) and healthy controls (HC), as well as elucidate its association with the periodontal clinical status...
July 10, 2017: Journal of Periodontology
T Sudo, Y Okada, K Ozaki, K Urayama, M Kanai, H Kobayashi, M Gokyu, Y Izumi, T Tanaka
Aggressive periodontitis (AgP) is characterized by rapid alveolar bone destruction and tooth loss early in life, and its etiology remains unclear. To explore the genetic risk factors of AgP, we performed genome-wide single-nucleotide polymorphism genotyping for identity-by-descent mapping and identified 32 distinct candidate loci, followed by whole exome sequencing with 2 pedigrees of AgP consisting of 3 cases and 1 control in 1 family and 2 sibling cases in the other. After variant filtering procedures and validation by targeted Sanger sequencing, we identified 2 missense mutations at 16q12 in NOD2 (p...
June 1, 2017: Journal of Dental Research
Akira Saito, Masafumi Horie, Kenichiro Ejiri, Akira Aoki, Sayaka Katagiri, Shogo Maekawa, Shinta Suzuki, Sophannary Kong, Tsuneto Yamauchi, Yoko Yamaguchi, Yuichi Izumi, Mitsuhiro Ohshima
Periodontitis is a chronic inflammatory disease that affects the interface of teeth and surrounding tissues. Gingival crevicular fluid (GCF) is an exudate of the periodontal tissues and can be collected from the gap between the tooth and gum (gingival sulcus or periodontal pocket) with paper strips. Testing of GCF is a low-cost and minimally invasive procedure. In a variety of diseases, microRNAs (miRNAs) in body fluids are implicated in pathogenesis, and are suggested as potential diagnostic biomarkers. Here, we profiled miRNAs in GCF (two chronic periodontitis, one aggressive periodontitis, and five healthy subjects) using miRCURY LNA™ Universal RT microRNA PCR System, which yielded quantitative measures of more than 600 miRNAs...
July 2017: FEBS Open Bio
Lourdes Román-Malo, Pedro Bullon
Periodontal disease is considered one of the main pathologic diseases occurring in humans. Its pathologic process involves inflammatory reactions producing periodontal bone resorption and the tooth loss. But some patients do not present an evident clinical inflammation with bone resorption, and in others, the inflammation is prominent without bone resorption. A key question could be to investigate a different way of responding to aggression. Inflammation requires a complex intracellular metabolic process, starting with the harmful recognition and activation of the inflammasome, continues the energy supply with the alteration of oxidative stress conditions, and finishes with the elimination of the aggression with autophagy/apoptosis mechanisms, then concludes with recovery...
July 5, 2017: International Journal of Molecular Sciences
Naira Maria Rebelatto Bechara Andere, Nídia Cristina Castro Dos Santos, Cássia Fernandes Araujo, Ingrid Fernandes Mathias, Tiago Taiete, Renato Corrêa Viana Casarin, Maria Aparecida Neves Jardini, Luciana M Shaddox, Mauro Pedrine Santamaria
BACKGROUND: The aim of the present study was to evaluate the periodontal clinical and microbiological responses and the possible adverse effects of clarithromycin combined to periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis. METHODS: Forty patients were selected and randomly assigned into two groups: Clarithromycin (CLM, n=20): one-stage full-mouth ultrasonic debridement (FMUD) associated with clarithromycin (500 mg - q12hrs for 3 days); Placebo (Placebo, n=20): FMUD associated with placebo pills...
July 3, 2017: Journal of Periodontology
Chaido Akrivopoulou, Ingrid M Green, Nikolaos Donos, Sean P Nair, Derren Ready
OBJECTIVES: Aggregatibacter actinomycetemcomitans is a recognised pathogen involved in aggressive periodontitis. Seven serotypes of A. actinomycetemcomitans exist with a range of virulence and distribution dependent on ethnicity and geography. The ability of A. actinomycetemcomitans to invade soft tissue can necessitate the use of systemic antibiotics for treatment, however variations in its antibiotic susceptibility exist dependent on geographical location. METHODS: Serotypes of A...
June 28, 2017: Journal of Global Antimicrobial Resistance
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