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aggressive periodontitis

Chi-Cheng Tsai, Ya-Ping Ho, Yu-Shian Chou, Kun-Yen Ho, Yi-Min Wu, Ying-Chu Lin
Aggregatibacter (Actinobacillus) actimycetemcomitans (Aa) is a gram-negative bacterium that colonizes the human oral cavity and is causative agent for localized aggressive (juvenile) periodontitis (AgP). In the middle of 1990s, a specific JP2 clone of belonging to the cluster of serotype b strains of Aa with highly leukotoxicity (leukotoxin, LtxA) able to kill human immune cells was isolated. JP2 clone of Aa was strongly associated with in particularly in rapidly progressing forms of aggressive periodontitis...
April 2018: Kaohsiung Journal of Medical Sciences
H D Zhang, L Zhang, D Shi, J Han, X Yan, Y S Xie, H X Meng
OBJECTIVE: To evaluate the survival rate and peri-implant clinical parameters of Locking-Taper implants in patients having lost their teeth due to non-periodontitis (NP) reasons, chronic periodontitis (CP) and aggressive periodontitis (AgP). METHODS: In the study, 145 subjects were installed with 315 Bicon Locking-Taper implants and followed up for 1-5 years. The subjects and implants were classified into three groups, tooth loss by NP, CP and AgP. NP included 44 subjects with 100 implants, CP 70 subjects with 132 implants and AgP 31 subjects with 83 implants...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Nico S Stumpp, Sarah A Konze, Rita Gerardy-Schahn, Meike Stiesch, Falk F R Buettner
Aggregatibacter (A.) actinomycetemcomitans is a periodontopathogenic bacterium causing aggressive periodontitis. Here we describe a single-step transconjugation system as novel and easily applicable protocol for site-specific genetic manipulation of A. actinomycetemcomitans. Deletion of PgaC, which is involved in the synthesis of biofilm matrix, led to a reduced biofilm formation.
April 5, 2018: Journal of Microbiological Methods
Ernie Maduratna Setiawatie, Vina Puji Lestari, Suryani Dyah Astuti
Background: Aggregatibacter actinomycetemcomitans ( A.actinomycetemcomitans ) is an anaerobic bacterium has been frequently associated with aggressive periodontitis. Photodynamic therapy (PDT) is a medical treatment to prevent infection progression that utilizes light to activate a photosensitizing agent. Doxycycline is an antibacterial having photosensitivity. This study aimed to evaluate potential doxycycline as an antibacterial and photosensitizer combine PDT against A.actinomycetemcomitans bacteria...
2018: African Journal of Infectious Diseases
Y Jockel-Schneider, A Kobsar, A Stellzig-Eisenhauer, U Vogel, S Störk, S Frantz, U Schlagenhauf, M Eigenthaler
In vitro studies revealed that Porphyromonas gingivalis (Pg), a pathogen intimately associated with the onset and progression of periodontitis, is able to activate platelets thus linking periodontal inflammation with the endangerment of vascular health. As wild-type Pg strains are characterized by major genetic heterogeneity, the commonness of platelet activating Pg strains in periodontitis patients is unknown as of yet. Therefore, this study evaluated the platelet activation capacity of wild-type Pg isolates sampled from patients with aggressive periodontitis...
April 2, 2018: Journal of Clinical Periodontology
Fatme Mouchref Hamasni, Fady El Hajj, Rima Abdallah
This case report exhibits a patient with generalized aggressive periodontitis who has been under maintenance for the past 12 years after being surgically treated in a single sitting and restored with dental implants. A 41-year-old systemically healthy male patient presented complaining of lower anterior teeth mobility and pain in the upper right quadrant. After clinical and radiographic examination, the upper right molars and lower anterior incisors were deemed unrestorable. Covered by doxycycline, the patient received a nonsurgical periodontal treatment...
2018: Case Reports in Dentistry
Ana Km Tormes, Manoela M De Bortoli, Rui M Júnior, Emanuel Ss Andrade
INTRODUCTION: Odontogenic infections originate from a tooth or from its supporting structures, generally secondary to a pulp necrosis, periodontal disease, pericoronitis, apical lesions, or complications of dental procedures, which can be restricted to the alveolus or can reach the jaws and face through maxillofacial spaces. These are the most common conditions which affect the head and neck regions. AIM: The aim of this study is to report a severe case of a cervicofacial odontogenic infection while discussing the most relevant aspects...
March 1, 2018: Journal of Contemporary Dental Practice
Vivek Tripathi, Sahib T Singh, Vivek Sharma, Ashish Verma, Chetan D Singh, Jaspreet S Gill
INTRODUCTION: Periodontitis is a common problem affecting a significant population of the world. For the assessment of oxidative stress of an individual, total oxidation status (TOS) and total antioxidant capacity (TAOC) are the significant biomarkers. Hence, we planned the present study to assess malondialde-hyde (MDA), TOS, TAOC levels, and oxidative stress index (OSI) in generalized aggressive periodontitis (GP) and chronic periodontitis (CP) patients. MATERIALS AND METHODS: The present study included assessment of 40 CP patients, 40 GP patients, and 40 healthy controls...
March 1, 2018: Journal of Contemporary Dental Practice
Cássio Volponi Carvalho, Luciana Saraiva, Flávio Paim Falcão Bauer, Rui Yoshio Kimura, Maria Luisa Silveira Souto, Carlos Cheque Bernardo, Cláudio Mendes Pannuti, Giuseppe Alexandre Romito, Francisco Emílio Pustiglioni
INTRODUCTION: Aggressive periodontitis (AP) is a condition that promotes breakdown of the periodontal tissues in a short time. In severe cases, pathologic migration of teeth and tooth loss can occur, producing esthetic and functional problems for the patient. Orthodontic treatment may be recommended to restore esthetics and masticatory function. We assessed the effects of orthodontic movement in the periodontal tissues of treated patients with AP. METHODS: Ten subjects (ages 25...
April 2018: American Journal of Orthodontics and Dentofacial Orthopedics
Zahra Alizadeh Tabari, Forooz Keshani, Majid Sharbatdaran, Amirhossein Banishahabadi, Marziyeh Nejatifard, Hossein Ghorbani
Background: Visfatin, also known as nicotinamide phosphoribosyltransferase, has been suggested as a pro-inflammatory and immunomodulating marker for periodontitis. The aim of this study was an immunohistochemical analysis of visfatin in gingival tissues of patients with chronic periodontitis and aggressive periodontitis. Materials and Methods: In this cross-sectional study based on clinical evaluation and inclusion and exclusion criteria. Twenty patients with generalized chronic periodontitis, 13 patients with generalized aggressive periodontitis, and 20 periodontally healthy individuals enrolled...
March 2018: Dental Research Journal
Liana F Brito, Zuila A Taboza, Virginia R Silveira, Flavia A Furlaneto, Cassiano K Rosing, Rodrigo O Rego
The purpose of this cross-sectional study was to evaluate the occurrence of bilateral symmetry in the distribution of clinical parameters in subjects with generalized aggressive periodontitis (GAP) and severe chronic periodontitis (SCP). The sample comprised 53 subjects with GAP and 33 with SCP. Probing depth (PD) and clinical attachment loss (CAL) were recorded from both buccal and lingual interproximal sites of incisors and molars. The symmetry of periodontal destruction was analyzed in terms of intraclass coefficient correlations (ICC) for pairs of contralateral sites at which PD and/or CAL was ≥5 mm at one of the sites of the subjects in each group...
2018: Journal of Oral Science
Rahul Suresh Bhansali, Ramreddy Krishnarao Yeltiwar, Kishore Bhat
Background: Association of neutrophil function abnormalities with localized aggressive periodontitis (LAP) has been reported in Indian population. There are no published studies on the familial aggregation of aggressive periodontitis (AP) and neutrophil function abnormalities associated with it in Indian population. The present study aimed to assess neutrophil chemotaxis, phagocytosis, and microbicidal activity in AP patients and their family members of Indian origin, who may or may not be suffering from AP...
November 2017: Journal of Indian Society of Periodontology
Romina Brignardello-Petersen
No abstract text is available yet for this article.
March 9, 2018: Journal of the American Dental Association
Rezvan Asgari, Kheirollah Yari, Kamran Mansouri, Mitra Bakhtiari
The interaction of FAS/FAS ligand (FASL) serves an important role in the upregulation of apoptotic processes through different mechanisms in cells. Previous studies have established that the polymorphisms FAS -670A/G and FASL -844C/T are associated with risk of generalized aggressive periodontitis (GAP) in different ethnic populations. Therefore, in the present study, it was investigated for the first time whether FAS -670A/G and FASL -844C/T polymorphisms were associated with risk of GAP in Iran. This case-control study performed the polymerase chain reaction-restriction fragment length polymorphism method in 25 patients with GAP and 110 normal subjects as controls...
April 2018: Biomedical Reports
Ajay Mahajan, Kanwarjit Asi, Nisha Thakur, Deepali Rasila
Generalized aggressive periodontitis (GAP) is a rare form of periodontitis resulting in early loss of teeth. Most of the clinical evidence available in literature focuses on the diagnosis and management aspects of GAP. Systemic manifestations of GAP have been reported infrequently. To the best of our knowledge, the present case report is the first-ever evidence providing a possible mechanism and link between GAP, dimorphic anemia, and mental depression suggesting that dimorphic anemia and mental depression are probable systemic manifestations of GAP...
September 2017: Journal of Indian Society of Periodontology
Tatjana Ramich, Anne Asendorf, Katrin Nickles, Gerhard M Oremek, Ralf Schubert, Luigi Nibali, Martin Wohlfeil, Peter Eickholz
AIM: The aim of the study is to assess the long-term effect of active periodontal therapy on serum inflammatory parameters in patients with aggressive (AgP) and chronic (ChP) periodontitis in a non-randomised clinical study. METHODS: Twenty-five ChP and 17 AgP were examined clinically prior to (baseline), 12 weeks and 60 months after subgingival debridement of all pockets within 2 days. Systemic antibiotics were prescribed if Aggregatibacter actinomycetemcomitans was detected (10 AgP, 8 ChP), flap surgery was rendered if required...
February 27, 2018: Clinical Oral Investigations
Sigrun Eick, Jasmin Nydegger, Walter Bürgin, Giovanni E Salvi, Anton Sculean, Christoph Ramseier
OBJECTIVES: The purpose of this retrospective study was to assess the impact of microbiological diagnostics on the outcomes of periodontal treatment with or without adjunctive use of systemic antibiotics. MATERIALS AND METHODS: Patient files were screened for microbiological analysis before (T1) and after non-surgical periodontal therapy (T2). Medical history, diagnosis, clinical data, and results of the microbiological analysis were extracted from the patient's file...
February 21, 2018: Clinical Oral Investigations
Mishal Piyush Shah, Sheela Kumar Gujjari, Veerendrakumar Siddhpur Chandrasekhar
Context: The over usage and broad use of antibiotics resulted in the emergence of resistant microorganisms to the drugs which also disturb the indigenous microflora, which include the Lactobacillus in the oral cavity. Hence, it is preferred to avoid the use of antibiotics. Aims: The hypothesis tested in this study was that 14 days of treatment with Lactobacillus brevis CD2 lozenges, L. brevis CD2 with oral doxycycline, or doxycycline alone would have a beneficial effect on periodontal health after 5 months...
July 2017: Journal of Indian Society of Periodontology
Alexandre Hugo Llanos, Carlos Guillermo Benítez Silva, Karina Tamie Ichimura, Estela Sanches Rebeis, Marcela Giudicissi, Marcelo Munhóes Romano, Luciana Saraiva
The purpose of this cross-sectional study was to investigate the effect of different forms of periodontal diseases on Oral Health-Related Quality of Life (OHRQoL). Fifty-two patients with Aggressive Periodontitis (AP) or Chronic Periodontitis (CP) were included: nine patients with Localized Aggressive Periodontitis (LAP), thirty-three patients with Generalized Aggressive Periodontitis (GAP) and ten patients with Generalized Chronic Periodontitis (GCP). Oral Health Impact Profile questionnaires (OHIP-14) were distributed after a clinical examination that measured the following periodontal parameters: tooth loss, bleeding on probing (BoP), probing depth (PD), gingival recession (REC) and clinical attachment level (CAL)...
2018: Brazilian Oral Research
Poulami Majumder, Keheibamding Thou, Mandar Bhattacharya, Vineet Nair, Sujay Ghosh, Subrata Kumar Dey
Periodontitis is a very common inflammatory oral disease. Tumor necrosis factor α (TNF-α), a cytokine has been involved with the gingival tissue destruction and remodeling occurrence. We aimed at investigation of the association of single nucleotide polymorphisms (SNPs) in TNF-α gene promoter region to the susceptibility of aggressive and chronic periodontitis in eastern Indian population. A total of 397 DNA samples from venous blood have been isolated, among them 40 individuals were aggressive periodontitis patient, 157 were identified chronic periodontitis patients and remaining 200 were healthy individuals...
February 15, 2018: Bioscience Reports
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