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aggressive periodontitis

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https://www.readbyqxmd.com/read/28099578/il-6-and-il-10-gene-polymorphisms-in-patients-with-aggressive-periodontitis-effects-on-gcf-serum-and-clinic-parameters
#1
Emine Pirim Gorgun, Hulya Toker, Ertan Mahir Korkmaz, Omer Poyraz
Genetic variations observed in cytokines affect periodontitis susceptibility. The aim of this study was to investigate interleukin(IL)-6(-174) and IL-10(-597) gene polymorphisms in generalized aggressive periodontitis (GAgP) patients. Also, we aimed to evaluate the effects of IL-6 and IL-10 gene polymorphisms on the clinical outcomes of non-surgical periodontal therapy and cytokine levels in gingival crevicular fluid(GCF) and serum. Fifty-three patients with GAgP and 50 periodontally healthy individuals were included in this study...
January 16, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28091448/oro-dental-characteristics-of-three-siblings-with-papillon-lefevre-syndrome
#2
O E Gungor, H Karayilmaz, H Yalcin, M Hatipoğlu
Papillon-Lefevre syndrome (PLS) is a rare autosomal recessive disorder, showing oral and dermatological manifestations in the form of aggressive periodontitis, leading to the premature loss of both primary and permanent teeth at a very young age and palmar-plantar hyperkeratosis. It was first described by two French physicians, Papillon and Lefevre in 1924. Immunologic, genetic, or possible bacterial etiologies have been thought to account for etiopathogenesis of PLS. Severe gingival inflammation and periodontal destruction occurred after the eruption of primary teeth...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28068272/surgical-resolution-of-an-aggressive-iatrogenic-root-perforation-in-a-maxillary-central-incisor-a-case-report-with-a-4-year-follow-up
#3
Ricardo Machado, Marcelo Agnoletto, Eduardo Donato Eing Engelke Back, Luiz Fernando Tomazinho, Fabricio Abel Paganini, Luiz Pascoal Vansan
The prognosis of teeth with root perforations depends on several factors, including size, location, and time since occurrence. Root perforations are clinical situations that can be solved by either nonsurgical or surgical approaches. The purpose of this article is to present a case of an aggressive iatrogenic root perforation in a maxillary right central incisor solved surgically using mineral trioxide aggregate (MTA). Even in an unfavorable situation, MTA was able to induce new bone formation and reestablish gingival and periodontal health, as confirmed in follow-up examinations at 2 and 4 years...
January 2017: General Dentistry
https://www.readbyqxmd.com/read/28050585/dataset-of-the-proteome-of-purified-outer-membrane-vesicles-from-the-human-pathogen-aggregatibacter-actinomycetemcomintans
#4
Thomas Kieselbach, Jan Oscarsson
The Gram-negative bacterium Aggregatibacter actinomycetemcomitans is an oral and systemic pathogen, which is linked to aggressive forms of periodontitis and can be associated with endocarditis. The outer membrane vesicles (OMVs) of this species contain effector proteins such as cytolethal distending toxin (CDT) and leukotoxin (LtxA), which they can deliver into human host cells. The OMVs can also activate innate immunity through NOD1- and NOD2-active pathogen-associated molecular patterns. This dataset provides a proteome of highly purified OMVs from A...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/28018430/gc-gene-polymorphisms-and-vitamin-d-binding-protein-levels-are-related-to-the-risk-of-generalized-aggressive-periodontitis
#5
Wenli Song, Xian'e Wang, Yu Tian, Xin Zhang, Ruifang Lu, Huanxin Meng
Objective. To explore whether GC (group-specific component) rs17467825, rs4588, and rs7041 polymorphisms are associated with generalized aggressive periodontitis. Methods. This case-control study recruited 372 patients with generalized aggressive periodontitis (group AgP) and 133 periodontal healthy subjects (group HP). GC rs17467825, rs4588, and rs7041 genotypes and plasmatic vitamin D-binding protein (DBP) were measured. Analysis of single SNP and multiple SNPs was performed and relevance between plasmatic DBP and haplotypes was analyzed...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28013554/the-emerging-roles-of-b-cells-as-partners-and-targets-in-periodontitis
#6
Moncef Zouali
Initial studies of periodontal disease suggested that T cell-mediated immunity against oral Gram-negative microorganisms is a key player in the pathogenesis of this inflammatory disease. Recent investigations, however, revealed that B cells are also engaged. Given their chief role in innate-like and adaptive immune responses, B cells could exert protective functions in periodontitis. However, the periodontal bacteria-specific antibody response is generally unable to halt disease progression in affected subjects, suggesting that the antibodies produced could exhibit low anti-bacterial blocking functions or opsonophagocytic potential, and/or unfavorable effects...
December 26, 2016: Autoimmunity
https://www.readbyqxmd.com/read/28013438/outcomes-of-implant-therapy-in-patients-with-a-history-of-aggressive-periodontitis-a-systematic-review-and-meta-analysis
#7
REVIEW
Charis Theodoridis, Andreas Grigoriadis, Georgios Menexes, Ioannis Vouros
OBJECTIVE: To investigate the outcomes of implant therapy in partially dentate patients treated for aggressive periodontitis (GAgP) in comparison to periodontally healthy (HP) and patients treated for chronic periodontitis (CP) utilizing radiographic and clinical parameters. MATERIAL AND METHODS: An electronic search of databases, supplemented by hand searching, was conducted to identify relevant clinical studies. Sequential screenings at the title, abstract and full-text levels were performed independently and in duplicate...
December 24, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28008419/trends-in-susceptibility-to-aggressive-periodontal-disease
#8
Nishat Shahabuddin, Kathleen Boesze-Battaglia, Edward T Lally
Aggregatibacter actinomycetemcomitans is a gram-negative microbe involved in periodontitis. Strains with varying degrees of virulence have been identified, in healthy and periodontally compromised individuals alike. Hosts mount differential immune responses to its various serotypes and virulence factors. Studies have explored host immune response in terms of antibody titers, leukocyte responses, and specific inflammatory mediators, questioning the ways in which the infectious microorganism survives. This mini-review will identify the key themes in immune response patterns of individuals both affected by and free from aggressive periodontal disease, thereby using it to understand various forms of periodontitis...
2016: Int J Dent Oral Health
https://www.readbyqxmd.com/read/27994415/detection-of-porphyromonas-gingivalis-and-treponema-denticola-in-chronic-and-aggressive-periodontitis-patients-a-comparative-polymerase-chain-reaction-study
#9
Ramniwas M Kumawat, Sindhu M Ganvir, Vinay K Hazarey, Asifa Qureshi, Hemant J Purohit
BACKGROUND: The detection frequency of Porphyromonas gingivalis and Treponema denticola in chronic periodontitis (CP) and aggressive periodontitis (AgP) is not explored well in Indian population. AIM: The study was undertaken to detect P. gingivalis and T. denticola in CP as well as in AgP patients using polymerase chain reaction (PCR), and to determine the relationship between the frequency of these two microorganisms and the severity of clinical periodontal parameters...
October 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27980332/antibiotics-in-aggressive-periodontitis-is-there-a-clinical-benefit
#10
Anjana Rajendra, Silvia Spivakovsky
Data sourcesMedline, Embase and CENTRAL databases were searched up to December 2014. Unpublished data were sought by searching a database listing unpublished studies OpenGray [http://www.opengrey.eu/], formerly OpenSIGLE.Study selectionRandomised clinical trials assessing treatment of patients with AgP comparing scaling and root planing (SRP) alone with SRP plus a single antibiotic or a combination of drugs with a minimum of three months follow-up were considered. Studies specifically designed to evaluate smokers or subjects with diabetes mellitus and HIV/AIDS were not included...
December 2016: Evidence-based Dentistry
https://www.readbyqxmd.com/read/27932832/should-implants-be-considered-for-patients-with-periodontal-disease
#11
E King, R Patel, A Patel, L Addy
Dental implants are seen as a good option for replacing missing teeth. The success and survival rates for implants are very high. Concerns are developing about the problem of peri-implantitis. The reports of its prevalence vary but it is noted that the presence of periodontal disease is a risk factor. The issue of peri-implantitis was raised in the House of Lords in 2014. Complaints relating to implants is on the rise with the General Dental Council. Placement of implants in patients with periodontal disease is not a treatment that should be done without a full periodontal assessment and stabilisation of periodontal disease first...
December 9, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27924604/exploring-genome-wide-expression-profiles-using-machine-learning-techniques
#12
Moritz Kebschull, Panos N Papapanou
Although contemporary high-throughput -omics methods produce high-dimensional data, the resulting wealth of information is difficult to assess using traditional statistical procedures. Machine learning methods facilitate the detection of additional patterns, beyond the mere identification of lists of features that differ between groups.Here, we demonstrate the utility of (1) supervised classification algorithms in class validation, and (2) unsupervised clustering in class discovery. We use data from our previous work that described the transcriptional profiles of gingival tissue samples obtained from subjects suffering from chronic or aggressive periodontitis (1) to test whether the two diagnostic entities were also characterized by differences on the molecular level, and (2) to search for a novel, alternative classification of periodontitis based on the tissue transcriptomes...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27900246/siga-peroxidase-and-collagenase-in-saliva-of-smokers-aggressive-periodontal-patients
#13
Myriam A Koss, Cecilia E Castro, Agustina M Gramajo, María E López
BACKGROUND: Tobacco smoking is strongly associated with destructive periodontal disease, alveolar bone loss and poor response to periodontal therapy. The aim of this study was to investigate the effect of smoking on antimicrobials and destructive proteins in the saliva of patients with generalized aggressive periodontal disease. MATERIAL AND METHODS: The study group consisted of 55 adult subjects. They were classified according to their clinical diagnoses either as having generalized aggressive periodontitis (n = 27; 13 smokers and 14 non-smokers) or as periodontitis-free control group (n = 28; 14 smokers and 14 non-smokers)...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27899029/treatment-compliance-in-patients-with-aggressive-periodontitis-a-retrospective-case-control-study
#14
Carolina Modin, Denise Abadji, Lottie Adler, Leif Jansson
OBJECTIVE: To investigate if differences according to discontinuation of treatment could be identified between patients with aggressive periodontitis and chronic periodontitis at two specialist clinics of periodontology irrespective of the effects of background factors. MATERIALS AND METHODS: This is a retrospective case-control study. The variables were registered from dental records. The population consisted of patients referred to two specialist clinics of periodontology during three years...
March 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/27886329/interleukin-8-251a-t-polymorphism-and-periodontitis-susceptibility-a-meta-analysis
#15
Z J Yang, X P Tang, Q G Lai, J B Ci, K F Yuan
The -251A/T polymorphism in the anti-inflammatory cytokine interleukin-8 (IL-8) gene has been implicated in susceptibility to periodontitis; however, this correlation has not been elucidated. In this meta-analysis, we investigated the association between the IL-8 -251A/T polymorphism and the risk of periodontitis. All eligible case-control studies published until August 2014 were identified and extracted from PubMed, Web of Science, EMBASE, China National Knowledge Internet, and WanFang databases. The strength of this association was accessed by pooled odds ratios (ORs) with 95% confidence intervals (CIs), using either a fixed- or random-effect model...
November 21, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27883202/the-role-of-platelets-in-inflammatory-immune-responses-in-generalized-aggressive-periodontitis
#16
Yalin Zhan, Ruifang Lu, Huanxin Meng, Xian'e Wang, Xiaojun Sun, Jianxia Hou
AIM: To investigate the relationship between inflammatory markers and platelet size in generalized aggressive periodontitis (GAgP). MATERIAL AND METHODS: Periodontal, inflammatory, and platelet indices were compared between 59 GAgP patients and 59 healthy subjects. Gingival biopsies from 5 patients and 5 healthy subjects were examined by immunohistochemistry and electron microscopy. Changes in patient periodontal and platelet indices were re-evaluated at 3 months after periodontal therapy...
November 24, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27834722/complete-genome-sequence-of-aggregatibacter-actinomycetemcomitans-strain-idh781
#17
Anthony C May, Rachel L Ehrlich, Sergey Balashov, Garth D Ehrlich, Mayilvahanan Shanmugam, Daniel H Fine, Narayanan Ramasubbu, Joshua Chang Mell, Carla Cugini
We report here the complete genomic sequence and methylome of Aggregatibacter actinomycetemcomitans strain IDH781. This rough strain is used extensively as a model organism to characterize localized aggressive periodontitis pathogenesis, the basic biology and oral cavity colonization of A. actinomycetemcomitans, and its interactions with other members of the oral microbiome.
November 10, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27834173/effects-of-aggregatibacter-actinomycetemcomitans-leukotoxin-on-neutrophil-migration-and-extracellular-trap-formation
#18
Josefine Hirschfeld, Helen M Roberts, Iain L C Chapple, Marijo Parčina, Søren Jepsen, Anders Johansson, Rolf Claesson
BACKGROUND: Aggressive periodontitis is associated with the presence of Aggregatibacter actinomycetemcomitans, a leukotoxin (Ltx)-producing periodontal pathogen. Ltx has the ability to lyse white blood cells including neutrophils. OBJECTIVES: This study was aimed at investigating the interactions between neutrophils and Ltx with regard to the chemotactic properties of Ltx and the release of neutrophil extracellular traps (NETs). METHODS: Neutrophils from healthy blood donors were isolated and incubated for 30 min and 3 h with increasing concentrations of Ltx (1, 10, and 100 ng/mL) as well as with A...
2016: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/27807931/esthetic-assessment-of-implants-placed-into-fresh-extraction-sockets-for-single-tooth-replacements-using-a-flapless-approach
#19
Roni Kolerman, Eitan Mijiritsky, Eitan Barnea, Areeje Dabaja, Joseph Nissan, Haim Tal
BACKGROUND: To validate the concept of immediate implant placement and nonfunctional loading for use in the esthetically sensitive anterior maxilla, clinical trials should ideally include objective esthetic criteria. PURPOSE: This study analyzed procedural results as graded by the pink esthetic score and white esthetic score (PES/WES). METHODS: Thirty-nine suitable patients (mean follow-up 44.82 ± 28 months) were evaluated. RESULTS: Thirty-eight implants fulfilled stringent criteria for successful osseointegration: absence of peri-implant radiolucency, implant mobility, suppuration, and pain...
November 2, 2016: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/27795356/mitogen-activated-protein-kinase-2-signaling-shapes-macrophage-plasticity-in-aggregatibacter-actinomycetemcomitans-induced-bone-loss
#20
Bethany A Herbert, Heidi M Steinkamp, Matthias Gaestel, Keith L Kirkwood
Aggregatibacter actinomycetemcomitans is associated with aggressive periodontal disease, which is characterized by inflammation-driven alveolar bone loss. A. actinomycetemcomitans activates the p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase 2 (MK2) stress pathways in macrophages that are involved in host responses. During the inflammatory process in periodontal disease, chemokines are upregulated to promote recruitment of inflammatory cells. The objective of this study was to determine the role of MK2 signaling in chemokine regulation during A...
January 2017: Infection and Immunity
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