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Transbronchial cryobiopsy

Elaine Yap, Irene Low
No abstract text is available yet for this article.
February 10, 2017: Journal of Bronchology & Interventional Pulmonology
Ilya G Berim, Ali I Saeed, Ahmed Awab, Adam Highley, Agnes Colanta, Fawad Chaudry
Fluoroscopy-guided transbronchial forceps biopsy has a low diagnostic yield in patients with radiographic suspicion of interstitial lung disease. Cryobiopsy has a higher diagnostic yield likely due to preserved lung architecture and larger biopsies; however, there is an increased risk of major airway bleeding and pneumothorax. Simultaneous use of endobronchial balloon blocker allows for containment of bleeding after cryobiopsy to the affected lobe. In the current article we describe use of radial ultrasound in identification of a target lung parenchyma without a major blood vessel adjacent to distal bronchi...
February 6, 2017: Journal of Bronchology & Interventional Pulmonology
Laurie Putz, Alain Mayné, Anne-Sophie Dincq
The indications for rigid bronchoscopy for interventional pulmonology have increased and include stent placements and transbronchial cryobiopsy procedures. The shared airway between anesthesiologist and pulmonologist and the open airway system, requiring specific ventilation techniques such as jet ventilation, need a good understanding of the procedure to reduce potentially harmful complications. Appropriate adjustment of the ventilator settings including pause pressure and peak inspiratory pressure reduces the risk of barotrauma...
2016: BioMed Research International
Kamonpun Ussavarungsi, Ryan M Kern, Anja C Roden, Jay H Ryu, Eric S Edell
BACKGROUND: Diagnostic evaluation of patients with diffuse parenchymal lung disease (DPLD) is best achieved by a multidisciplinary team correlating clinical, radiologic, and pathologic features. Surgical lung biopsies remain the gold standard for histopathologic diagnosis of idiopathic interstitial pneumonias. Emerging data suggest an increasing role for transbronchial cryobiopsy (TBC) in DPLD evaluation. We describe our experience with TBC in patients with DPLD. METHODS: We retrospectively reviewed medical records of patients with radiographic features of DPLD who underwent TBC at Mayo Clinic, Rochester, Minnesota in June 2013-September 2015...
September 19, 2016: Chest
Thomas V Colby, Sara Tomassetti, Alberto Cavazza, Alessandra Dubini, Venerino Poletti
Context .- Transbronchial cryobiopsy has recently been proposed as an alternative to surgical biopsy in the diagnosis of diffuse lung disease. Objective .- To familiarize pathologists with transbronchial cryobiopsy, including what it is, how it is performed, how it compares to other techniques of lung biopsy in diffuse lung disease, what are the technical issues relating to it, what the complications are, how cryobiopsies should be interpreted, and the clinical usefulness of cryobiopsy. Data Sources .- All the available literature on cryobiopsy in diffuse lung disease through May 2016, primarily in the last 5 years, was reviewed, and some unpublished data known to the authors were included...
September 2, 2016: Archives of Pathology & Laboratory Medicine
L Richeldi
The recent approval of two safe and effective treatments for patients with idiopathic pulmonary fibrosis (IPF) had as a direct consequence the absolute need for an accurate and early diagnosis. The standard approach to IPF diagnosis has proven to be effective and emphasized the importance of clinical and laboratory evaluations to exclude known causes of pulmonary fibrosis. At the same time, chest high-resolution computed tomography (HRCT) has proven to be the crucial initial diagnostic test, by identifying those patients who should undergo surgical lung biopsy to secure a confident diagnosis and an adequate treatment...
September 2016: QJM: Monthly Journal of the Association of Physicians
C Sharp, M McCabe, H Adamali, A R Medford
BACKGROUND: Histological diagnosis by surgical lung biopsy for interstitial lung disease (ILD) is currently limited. Transbronchial cryobiopsy via flexible bronchoscope may this for more patients. The relative costs, diagnostic yields and safety of this approach and more traditional approaches have not been determined. OBJECTIVES: To perform a systematic review and meta-analysis of transbronchial cryobiopsy, forceps transbronchial biopsy and video assisted (VATS) surgical lung biopsy assessing their relative diagnostic yields and safety...
August 13, 2016: QJM: Monthly Journal of the Association of Physicians
Kerri A Johannson, Veronica S Marcoux, Paul E Ronksley, Christopher J Ryerson
RATIONALE: The diagnostic usefulness and safety of transbronchial lung cryobiopsy for the evaluation of interstitial lung disease remain unclear. OBJECTIVES: This systematic review and metaanalysis aims to establish the diagnostic accuracy and yield of transbronchial cryobiopsy for interstitial lung diseases. METHODS: We searched MedLine, EMBASE, Cochrane Central Register of Controlled Trials, and conference proceedings to identify studies assessing the diagnostic accuracy (compared with surgical biopsy) or yield of transbronchial lung cryobiopsy for interstitial lung disease (from database inception to January 2016)...
October 2016: Annals of the American Thoracic Society
Kirtee Raparia, Dara L Aisner, Timothy Craig Allen, Mary Beth Beasley, Alain Borczuk, Philip T Cagle, Vera Capelozzi, Sanja Dacic, Lida P Hariri, Keith M Kerr, Sylvie Lantuejoul, Mari Mino-Kenudson, Natasha Rekhtman, Anja C Roden, Sinchita Roy-Chowdhuri, Lynette Sholl, Maxwell L Smith, Eric Thunnissen, Ming Sound Tsao, Yasushi Yatabe
Transbronchial lung cryobiopsy involves using a cryoprobe rather than forceps to obtain a bronchoscopic biopsy. Recent studies have shown that transbronchial cryobiopsy provides a larger specimen than conventional transbronchial forceps biopsy, and that the interobserver agreement in the interpretation of cryobiopsy specimens is comparable to that of a surgical lung biopsy. This is encouraging, and transbronchial lung cryobiopsy clearly has a role in the workup and diagnosis of interstitial lung diseases. However, very few patients who have been studied underwent both transbronchial lung cryobiopsy and surgical lung biopsy, and the available data suggest that the diagnostic accuracy of cryobiopsy may not be similar to that of surgical lung biopsy...
July 21, 2016: Archives of Pathology & Laboratory Medicine
Sergej Griff, Wim Ammenwerth, Nicolas Schönfeld, Torsten T Bauer, Thomas Mairinger, Torsten-Gerriet Blum, Jens Kollmeier, Wolfram Grüning
No abstract text is available yet for this article.
2016: Diagnostic Pathology
Matthew Ing, Rema A Oliver, Brian G G Oliver, William R Walsh, Jonathan P Williamson
BACKGROUND: Transbronchial lung biopsy using a cryoprobe is a novel way of sampling lung parenchyma. Correlation of freezing time with biopsy size and complications has not been evaluated in vivo. OBJECTIVES: The primary aim of the study is to evaluate the correlation between transbronchial cryobiopsy freezing time and size. The secondary aims are to evaluate histological quality of the biopsy and evaluate procedure-associated complications. METHODS: Transbronchial lung cryobiopsies were obtained from two anaesthetised sheep using a 1...
2016: Respiration; International Review of Thoracic Diseases
José A Cascante, Pilar Cebollero, Sonia Herrero, Adriana Yagüe, Ana Echegoyen, Jesús Elizalde, Javier Hueto
BACKGROUND: A definitive and specific diagnosis of interstitial lung disease (ILD) often requires a histologic analysis of the lung parenchyma. A transbronchial biopsy with forceps has a limited diagnostic yield for idiopathic interstitial pneumonias. The incorporation of a transbronchial lung cryobiopsy for diagnosing ILD appears to be very promising, although there are only a few published studies in this regard. Our paper shows the results of using this technique in our center. METHODS: This was a prospective study including 55 patients with ILD diagnosed from January 2012 to January 2015...
July 2016: Journal of Bronchology & Interventional Pulmonology
Lars Hagmeyer, Dirk Theegarten, Marcel Treml, Christina Priegnitz, Winfried Randerath
BACKGROUND: Transbronchial Cryobiopsy (Cryo-TBB) represents a new approach for sampling lung tissue in interstitial lung disease (ILD). OBJECTIVES: Comparing the reliability of Cryo-TBB results and the procedure's complication rates with the procedure of surgical lung biopsy (SLB). METHODS: ILD subjects with the need of lung tissue sampling are analyzed in this prospective trial. To determine the relevance of procedure-related complications the pooled data from the ongoing and previous Cryo-TBB studies were compared with pooled data from previous SLB studies in an interim analysis...
March 29, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
Robert J Lentz, Joshua P Fessel, Joyce E Johnson, Fabien Maldonado, Robert F Miller, Otis B Rickman
No abstract text is available yet for this article.
April 1, 2016: American Journal of Respiratory and Critical Care Medicine
Oormila Ganganah, Shu Liang Guo, Manu Chiniah, Yi Shi Li
Forceps biopsy (FB) is the most commonly used diagnostic tool for lung pathologies. FB is associated with a high diagnostic failure rate. Cryobiopsy (CB) is a novel technique providing a larger specimen size, few artefacts, more alveolar parts and superior diagnostic yield. CB, however, has drawbacks such as higher bleeding and pneumothorax rate. We conducted a meta-analysis to investigate the specimen area, diagnostic rate and bleeding severity in CB versus FB in interstitial lung diseases (ILDs) and lung tumours...
2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
Venerino Poletti, Claudia Ravaglia, Sara Tomassetti
PURPOSE OF REVIEW: The diagnostic yield of conventional transbronchial lung biopsy varies among various parenchymal lung diseases: in pulmonary sarcoidosis and lymphangitis carcinomatosa, a diagnosis can be obtained in up to 80% of patients; this method is considered inadequate, however, in identifying more complex histological patterns such as usual interstitial pneumonitis or nonspecific interstitial pneumonitis, mainly because the specimens are tiny and the interpretation is confounded by crush artifacts...
May 2016: Current Opinion in Pulmonary Medicine
Venerino Poletti
No abstract text is available yet for this article.
2016: Respiration; International Review of Thoracic Diseases
Claudia Ravaglia, Martina Bonifazi, Athol U Wells, Sara Tomassetti, Carlo Gurioli, Sara Piciucchi, Alessandra Dubini, Paola Tantalocco, Stefano Sanna, Eva Negri, Irene Tramacere, Valentina Anna Ventura, Alberto Cavazza, Andrea Rossi, Marco Chilosi, Carlo La Vecchia, Stefano Gasparini, Venerino Poletti
BACKGROUND: A diagnosis of interstitial lung diseases (ILDs) may include surgical lung biopsy (SLB), which is associated with significant morbidity and mortality and also appreciable costs. Transbronchial lung cryobiopsy (TBLC) is adopting an important role. OBJECTIVES: The aim of this study was to compare the diagnostic yield (DY) and safety of TBLC and SLB in a large cohort of patients and to perform a systematic review of the literature as well as a meta-analysis...
2016: Respiration; International Review of Thoracic Diseases
Karl-Josef Franke, Walter Linzenbold, Daniela Nuessle, Markus Enderle, Hans Boesmueller, Georg Nilius, Jürgen Hetzel
BACKGROUND: Transbronchial cryobiopsy (TBCB) is a minimally invasive procedure to establish a diagnosis of interstitial lung disease though with the disadvantage that samples have to be extracted together with the bronchoscope. OBJECTIVES: The aim of the present study was to evaluate the feasibility of a new cryoprobe with which biopsy samples can be obtained through the working channel of the flexible bronchoscope. METHODS: The feasibility of obtaining transbronchial specimens with TBCB was tested and the technique was compared to transbronchial forceps biopsy (TBFB) in a prospectively randomized ex vivo animal study using a standard flexible bronchoscopy technique...
2016: Respiration; International Review of Thoracic Diseases
Alfonso Torrego, Pallav L Shah
No abstract text is available yet for this article.
2016: Respiration; International Review of Thoracic Diseases
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