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Ang 2 AND ROS

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https://www.readbyqxmd.com/read/27896943/ang-1-7-protects-cardiomyocytes-against-hg-induced-injuries-through-inhibiting-ros-activated-leptin-p38-mapk-erk1-2-pathways-but-not-leptin-jnk-pathway-in-vitro
#1
Yiyan Lei, Qing Xu, Bo Zeng, Wei Zhang, Yulan Zhen, Yuansheng Zhai, Fei Cheng, Weiyi Mei, Dongdan Zheng, Jianqiang Feng, Jun Lan, Jingfu Chen
AIMS: Angiotensin-(1-7) [Ang-(1-7)], recognized as a new bioactive peptide in renin-angiotensin system (RAS), shows biological and pharmacological properties in diabetic cardiovascular diseases. Leptin induced-p38 MAPK pathway has been reported to contribute to the high glucose (HG)-induced injury. In this study, we demonstrated the mechanism that how Ang-(1-7) can protect from HG-stimulated injuries in H9c2 cells. METHODS: H9c2 cells were treated with 35 mM glucose (HG) for 24 h to establish a model of HG-induced damage...
November 29, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27822383/neuronal-nitric-oxide-synthase-in-hypertension-an-update
#2
REVIEW
Yin Hua Zhang
Hypertension is a prevalent condition worldwide and is the key risk factor for fatal cardiovascular complications, such as stroke, sudden cardiac death and heart failure. Reduced bioavailability of nitric oxide (NO) in the endothelium is an important precursor for impaired vasodilation and hypertension. In the heart, NO deficiency deteriorates the adverse consequences of pressure-overload and causes cardiac hypertrophy, fibrosis and myocardial infarction which lead to fatal heart failure and sudden cardiac death...
2016: Clinical Hypertension
https://www.readbyqxmd.com/read/27807688/angiotensin-ii-induced-early-and-late-inflammatory-responses-through-noxs-and-mapk-pathways
#3
Xi Zhang, Jia Yang, Xinyi Yu, Si Cheng, Hua Gan, Yunfeng Xia
Angiotensin II (Ang II) dysregulation has been determined as cause or an effect of many diseases. The relationship between Ang II and reactive oxygen species (ROS), which are generated by enzymes in the nicotinamide adenine dinucleotide phosphate oxidase (NOX) family, has been the focus of many researchers for years. Inflammation in response to the activities of various NOXs with differing time-dependent characteristics was reported. It is still unclear how these factors interplay over the course of the inflammatory response and how signal transduction through mitogen-activated protein kinase (MAPK) pathways...
November 2, 2016: Inflammation
https://www.readbyqxmd.com/read/27754201/ish-pre-2-the-vascular-phenotype-in-hypertension-molecular-mechanisms-and-clinical-implications
#4
Rhian M Touyz
Pathophysiological mechanisms contributing to hypertension include endothelial dysfunction and vascular ignalling. These changes are initially adaptive but chronically become maladaptive leading to vascular damage and loss of function. Common to these processes are changes in the characteristics of vascular cells to a pro-infl ammatory, vasoconstrictory and proliferative phenotype, infl uenced by activation of the RAS and oxidative stress. Increased ROS production and decreased cellular antioxidant defense mechanisms, contribute to oxidative stress, which infl uences redox-sensitive Ang II ignalling that promotes vascular injury in hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754054/os-15-02-matrix-metalloproteinase-2-knockout-protects-from-angiotensin-ii-induced-vascular-injury-in-part-via-inhibition-of-egfr-and-erk1-2-activation
#5
Pierre Paradis, Tlili Barhoumi, Muhammad Oneeb Rehman Mian, Julio C Fraulob-Aquino, Asia Rehman, Nourredine Idris-Khodja, Ernesto L Schiffrin
OBJECTIVE: Matrix metalloproteinase 2 (MMP2) is involved in cardiovascular disease. Whether MMP2 plays a role in hypertension and vascular damage is unknown. We hypothesized that Mmp2 knockout will prevent angiotensin (Ang) II-induced hypertension and vascular injury. DESIGN AND METHOD: Mmp2 knockout (Mmp2) and wild-type (WT) mice were infused with Ang II (1000 ng/kg/min, SC) for 14 days. Systolic blood pressure (SBP) was measured by telemetry, and mesenteric artery (MA) endothelial function and vascular remodeling by pressurized myography...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27698414/scaffold-hopping-toward-agomelatine-novel-3-4-dihydroisoquinoline-compounds-as-potential-antidepressant-agents
#6
Yang Yang, Wei Ang, Haiyue Long, Ying Chang, Zicheng Li, Liangxue Zhou, Tao Yang, Yong Deng, Youfu Luo
A scaffold-hopping strategy toward Agomelatine based on in silico screening and knowledge analysis was employed to design novel antidepressant agents. A series of 3, 4-dihydroisoquinoline compounds were selected for chemical synthesis and biological assessment. Three compounds (6a-1, 6a-2, 6a-9) demonstrated protective effects on corticosterone-induced lesion of PC12 cells. Compound 6a-1 also displayed low inhibitory effects on the growth of HEK293 and L02 normal cells and it was further evaluated for its potential antidepressant effects in vivo...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27687768/angiotensin-1-7-abrogates-angiotensin-ii-induced-proliferation-migration-and-inflammation-in-vsmcs-through-inactivation-of-ros-mediated-pi3k-akt-and-mapk-erk-signaling-pathways
#7
Feng Zhang, Xingsheng Ren, Mingxia Zhao, Bing Zhou, Ying Han
The proliferation, migration and inflammation of vascular smooth muscle cells (VSMCs) contribute to the pathogenesis and progression of several cardiovascular diseases such as atherosclerosis and hypertension. Angiotensin (Ang)-(1-7) and Ang II are identified to be involved in regulating cardiovascular activity. The present study is designed to determine the interaction between Ang-(1-7) and Ang II on VSMCs proliferation, migration and inflammation as well as their underlying mechanisms. We found that Ang-(1-7) significantly suppressed the positive effects of Ang II on VSMCs proliferation, migration and inflammation, as well as on induction of the phosphorylation of Akt and ERK1/2 and increase of superoxide anion level and NAD(P)H oxidase activity in VSMCs, whereas Ang-(1-7) alone had no significant effects...
September 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27643158/ish-pre-2-the-vascular-phenotype-in-hypertension-molecular-mechanisms-and-clinical-implications
#8
Rhian M Touyz
Pathophysiological mechanisms contributing to hypertension include endothelial dysfunction and vascular ignalling. These changes are initially adaptive but chronically become maladaptive leading to vascular damage and loss of function. Common to these processes are changes in the characteristics of vascular cells to a pro-infl ammatory, vasoconstrictory and proliferative phenotype, infl uenced by activation of the RAS and oxidative stress. Increased ROS production and decreased cellular antioxidant defense mechanisms, contribute to oxidative stress, which infl uences redox-sensitive Ang II ignalling that promotes vascular injury in hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642974/os-15-02-matrix-metalloproteinase-2-knockout-protects-from-angiotensin-ii-induced-vascular-injury-in-part-via-inhibition-of-egfr-and-erk1-2-activation
#9
Pierre Paradis, Tlili Barhoumi, Muhammad Oneeb Rehman Mian, Julio C Fraulob-Aquino, Asia Rehman, Nourredine Idris-Khodja, Ernesto L Schiffrin
OBJECTIVE: Matrix metalloproteinase 2 (MMP2) is involved in cardiovascular disease. Whether MMP2 plays a role in hypertension and vascular damage is unknown. We hypothesized that Mmp2 knockout will prevent angiotensin (Ang) II-induced hypertension and vascular injury. DESIGN AND METHOD: Mmp2 knockout (Mmp2) and wild-type (WT) mice were infused with Ang II (1000 ng/kg/min, SC) for 14 days. Systolic blood pressure (SBP) was measured by telemetry, and mesenteric artery (MA) endothelial function and vascular remodeling by pressurized myography...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27570480/gamma-secretase-inhibitor-prevents-proliferation-and-migration-of-ductus-arteriosus-smooth-muscle-cells-through-the-notch3-hes1-2-5-pathway
#10
Jiunn-Ren Wu, Jwu-Lai Yeh, Shu-Fen Liou, Zen-Kong Dai, Bin-Nan Wu, Jong-Hau Hsu
Patent ductus arteriosus (PDA) can cause morbidity and mortality in neonates. Vascular remodeling, characterized by proliferation and migration of smooth muscle cells (SMCs), is an essential process for postnatal DA closure. Notch signaling is an important mediator of vascular remodelling but its role in DA is unkonwn. We investigated the effects and underlying mechanisms of γ-secretase inhibitor DAPT, a Notch signaling inhibitor on angiotensin II (Ang II)-induced proliferation and migration of DASMCs. Proliferation and migration of DASMCs cultured from neonatal Wistar rats were induced by Ang II, with or without DAPT pre-treatment...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27507578/hno-suppresses-lps-induced-inflammation-in-bv-2-microglial-cells-via-inhibition-of-nf-%C3%AE%C2%BAb-and-p38-mapk-pathways
#11
Yebo Zhou, Zhiyuan Wu, Xu Cao, Lei Ding, ZhengShun Wen, Jin-Song Bian
Both hydrogen sulfide (H2S) and nitric oxide (NO) are important gaseous mediators. We and others previously reported that these two gases react with each other to generate a new mediator, nitroxyl (HNO), and regulate cardiovascular functions. In this study, we demonstrated for the first time that the interaction between the two gases also existed in microglia. The biological functions of HNO in microglial cells were further studied with Angeli's salt (AS), an HNO donor. We found that AS attenuated lipopolysaccharide (LPS)-evoked production of reactive oxygen species (ROS) and pro-inflammatory cytokines (e...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27506987/blackberry-raspberry-and-black-raspberry-polyphenol-extracts-attenuate-angiotensin-ii-induced-senescence-in-vascular-smooth-muscle-cells
#12
Rafaela G Feresin, Jingwen Huang, DawnKylee S Klarich, Yitong Zhao, Shirin Pourafshar, Bahram H Arjmandi, Gloria Salazar
Activation of angiotensin II (Ang II) signaling during aging increases reactive oxygen species (ROS) leading to vascular senescence, a process linked to the onset and progression of cardiovascular diseases (CVD). Consumption of fruits and vegetables, particularly berries, is associated with decreased incidence of CVD, which has mainly been attributed to the polyphenol content of these foods. Thus, the objective of this study was to investigate the role of blackberry (BL), raspberry (RB), and black raspberry (BRB) polyphenol extracts in attenuating Ang II-induced senescence in vascular smooth muscle cells (VSMCs) and to determine the molecular mechanisms involved...
October 12, 2016: Food & Function
https://www.readbyqxmd.com/read/27492718/epigallocatechin-3-gallate-inhibits-angiotensin-ii-induced-c-reactive-protein-generation-through-interfering-with-the-at1-ros-erk1-2-signaling-pathway-in-hepatocytes
#13
Jingjing Zhao, Juntian Liu, Xiaoming Pang, Xiaolu Zhang, Shuyue Wang, Di Wu
Inflammation plays a key role in many chronic diseases such as cardiovascular diseases and liver diseases. As a representative inflammatory molecule, C-reactive protein (CRP) is mainly produced in the liver. Hepatic CRP plays a direct role in the inflammatory hepatic diseases and in development of atherosclerosis when entering into the blood circulation. In the present study, we observed the effect of epigallocatechin-3-gallate (EGCG) on Ang II-induced CRP generation in hepatocytes and the molecular mechanism...
November 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27430410/antioxidant-effect-of-angiotensin-1%C3%A2-7-in-the-protection-of-pancreatic-%C3%AE-cell-function
#14
Fen Zhang, Chang Liu, Lei Wang, Xi Cao, Ying Ying Wang, Jin Kui Yang
It is well known that the local renin-angiotensin system (RAS) is activated in the diabetic state, which results in an increase in the level of oxidative stress injury to pancreatic β cells. The angiotensin‑converting enzyme 2 (ACE2)/angiotensin (1‑7) [Ang (1‑7)]/Mas axis is a negative regulator of the classical renin‑angiotensin system. In order to investigate the antioxidant effect of Ang (1‑7) on pancreatic β cells, INS‑1 cells were cultured and oxidative stress was induced by treatment with H2O2...
September 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27381955/reactive-oxygen-species-derived-from-nadph-oxidase-1-and-mitochondria-mediate-angiotensin-ii-induced-smooth-muscle-cell-senescence
#15
I-Ching Tsai, Zih-Cian Pan, Hui-Pin Cheng, Chen-Hsiu Liu, Bor-Tyng Lin, Meei Jyh Jiang
Cellular senescence has emerged as an important player in both physiology and pathology. Excessive reactive oxygen species (ROS) is known to mediate cellular senescence. NADPH oxidases are major sources for ROS production in the vascular wall; the roles of different NADPH oxidase isoforms in cellular senescence remain unclear, however. We investigated the roles of two NADPH oxidase isoforms in mitochondrial dysfunction during angiotensin II (Ang II)-induced cellular senescence of human aortic vascular smooth muscle cells (VSMCs)...
September 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27379421/role-of-pkc%C3%AE-in-enhanced-expression-of-gq%C3%AE-plc%C3%AE-1-proteins-and-vsmc-hypertrophy-in-spontaneously-hypertensive-rats
#16
Mohammed Emehdi Atef, Madhu B Anand-Srivastava
Gqα signaling has been implicated in cardiac hypertrophy. In addition, angiotensin II (Ang II) was also shown to induce its hypertrophic effect through Gqα and PKCδ activation. We recently showed the role of enhanced expression of Gqα/PLCβ1 proteins in vascular smooth muscle cell (VSMC) hypertrophy, however, the role of PKCδ in VSMC hypertrophy in animal model is still lacking. The present study was therefore undertaken to examine the role of PKCδ and the associated signaling mechanisms in VSMC hypertrophy using 16-week-old spontaneously hypertensive rats (SHR)...
2016: PloS One
https://www.readbyqxmd.com/read/27364911/fgf21-represses-cerebrovascular-aging-via-improving-mitochondrial-biogenesis-and-inhibiting-p53-signaling-pathway-in-an-ampk-dependent-manner
#17
Xiao-Mei Wang, Hang Xiao, Ling-Lin Liu, Dang Cheng, Xue-Jun Li, Liang-Yi Si
Cerebrovascular aging has a high relationship with stroke and neurodegenerative disease. In the present study, we evaluated the influence of fibroblast growth factor 21 (FGF21) on angiotensin (Ang II)-mediated cerebrovascular aging in human brain vascular smooth muscle cells (hBVSMCs). Ang II induced remarkable aging-phenotypes in hBVSMCs, including enhanced SA-β-gal staining and NBS1 protein expression. First, we used immunoblotting assay to confirm protein expression of FGF21 receptor (FGFR1) and the co-receptor β-Klotho in cultured hBVSMCs...
August 15, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27363651/protective-effects-of-naringenin-in-cardiorenal-syndrome
#18
Yan Liu, Wenjun An, Aibao Gao
BACKGROUND: Cardiorenal syndrome is a complicated and bidirectional interrelationship between the heart and kidneys. Naringenin (NG) is a naturally occurring flavonoid possessing various biological and pharmacological properties. MATERIALS AND METHODS: We tested whether NG could improve cardiac and renal function in a rat model of cardiorenal syndrome. RESULTS: The results showed that NG-attenuated cardiac remodeling and cardiac dysfunction in rats with cardiorenal syndrome, as evidenced by decrease of left ventricle weight (LVW), increase of body weight (BW), decrease of LVW/BW, decrease of concentrations of serum creatinine, blood urea nitrogen, type-B natriuretic peptide, aldosterone, angiotensin (Ang) II, C-reactive protein, and urine protein, increase of left ventricular systolic pressure and falling rates of left ventricular pressure (dp/dtmax), and decrease of left ventricular diastolic pressure, left ventricular end-diastolic pressure, and -dp/dtmax...
June 15, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27179211/long-term-administration-of-ranolazine-attenuates-diastolic-dysfunction-and-adverse-myocardial-remodeling-in-a-model-of-heart-failure-with-preserved-ejection-fraction
#19
Antonella De Angelis, Donato Cappetta, Elena Piegari, Barbara Rinaldi, Loreta Pia Ciuffreda, Grazia Esposito, Fiorella Angelica Valeria Ferraiolo, Alessia Rivellino, Rosa Russo, Maria Donniacuo, Francesco Rossi, Konrad Urbanek, Liberato Berrino
BACKGROUND: To investigate the effects of chronic administration of ranolazine (RAN) on experimental model of heart failure with preserved ejection fraction. METHODS: Seven-weeks old Dahl salt-sensitive rats were fed a high salt diet for 5weeks to induce hypertension. Afterwards, rats continued with a high salt diet and were administered either with vehicle or RAN (20mg/kg/die, ip) for the following 8weeks. Control rats were maintained on a low salt diet. RESULTS: While systolic parameters were not altered, diastolic parameters were changed in high salt animals...
August 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27163380/mineralocorticoid-and-angiotensin-ii-type-1-receptors-in-the-subfornical-organ-mediate-angiotensin-ii-induced-hypothalamic-reactive-oxygen-species-and-hypertension
#20
Hong-Wei Wang, Bing S Huang, Roselyn A White, Aidong Chen, Monir Ahmad, Frans H H Leenen
Activation of angiotensinergic pathways by central aldosterone (Aldo)-mineralocorticoid receptor (MR) pathway plays a critical role in angiotensin II (Ang II)-induced hypertension. The subfornical organ (SFO) contains both MR and angiotensin II type 1 receptors (AT1R) and can relay the signals of circulating Ang II to downstream nuclei such as the paraventricular nucleus (PVN), supraoptic nucleus (SON) and rostral ventrolateral medulla (RVLM). In Wistar rats, subcutaneous (sc) infusion of Ang II at 500ng/min/kg for 1 or 2weeks increased reactive oxygen species (ROS) as measured by dihydroethidium (DHE) staining in a nucleus - specific pattern...
August 4, 2016: Neuroscience
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