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https://www.readbyqxmd.com/read/29139113/prevalence-of-headache-in-patients-with-mitochondrial-disease-a-cross-sectional-study
#1
Torsten Kraya, Marcus Deschauer, Pushpa Raj Joshi, Stephan Zierz, Charly Gaul
BACKGROUND: Mitochondrial diseases are a heterogeneous group of diseases with different phenotypes and genotypes. Headache and, particularly migraine, seems to occur often in patients with MELAS and in patients with CPEO phenotypes. The International Classification of Headache Disorders (ICHD-3 beta) has classified headache as a secondary entity only in MELAS patients. Other headache phenotypes in mitochondrial diseases are not considered in ICHD-3beta. In this study, we analyzed headache phenomenology in a large group of patients with mitochondrial disorders...
November 15, 2017: Headache
https://www.readbyqxmd.com/read/29109957/-gold-pressed-essential-oil-an-essay-on-the-volatile-fragment-from-citrus-juice-industry-by-products-chemistry-and-bioactivity
#2
V N Kapsaski-Kanelli, E Evergetis, A Michaelakis, D P Papachristos, E D Myrtsi, S D Koulocheri, S A Haroutounian
Present essay explores the potentials of Citrus juice industry's by-products as alternative bioactive natural products resources. Four crude Cold Pressed Essential Oils (CPEOs), derived from orange, lemon, grapefruit, and mandarin, were studied. All CPEOs were subjected to water distillation, in order to obtain the volatile fragment, which was further fractionated with respect to distillation period in two parts, concluding to eight samples. These samples along with the four original CPEOs were assessed in relation to their phytochemical content and their repellent and larvicidal properties against Asian Tiger Mosquito...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29034153/efficacy-of-frontalis-suspension-with-silicone-rods-in-ptosis-patients-with-poor-bell-s-phenomenon
#3
Khyati P Shah, Bipasha Mukherjee
PURPOSE: The purpose of the study was to evaluate the efficacy of silicone rods as frontalis sling for correction of ptosis associated with poor Bell's phenomenon in specific situations. MATERIALS AND METHODS: A retrospective interventional case series of 25 eyes of 19 patients who underwent frontalis suspension surgery with silicone rods for ptosis correction from May 2006 to April 2011, was performed. Inclusion criteria included severe ptosis with poor Bell's phenomenon...
July 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/28867671/the-development-and-optimisation-of-3d-black-blood-r2-mapping-of-the-carotid-artery-wall
#4
Jianmin Yuan, Martin J Graves, Andrew J Patterson, Andrew N Priest, Pascal P R Ruetten, Ammara Usman, Jonathan H Gillard
PURPOSE: To develop and optimise a 3D black-blood R2* mapping sequence for imaging the carotid artery wall, using optimal blood suppression and k-space view ordering. METHODS: Two different blood suppression preparation methods were used; Delay Alternating with Nutation for Tailored Excitation (DANTE) and improved Motion Sensitive Driven Equilibrium (iMSDE) were each combined with a three-dimensional (3D) multi-echo Fast Spoiled GRadient echo (ME-FSPGR) readout...
December 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28695670/mitochondrial-dysfunction-and-cerebral-metabolic-abnormalities-in-patients-with-mitochondrial-encephalomyopathy-subtypes-evidence-from-proton-mr-spectroscopy-and-muscle-biopsy
#5
Feng-Nan Niu, Hai-Lan Meng, Lei-Lei Chang, Hong-Yan Wu, Wei-Ping Li, Ren-Yuan Liu, Hui-Ting Wang, Bing Zhang, Yun Xu
AIMS: Accumulated evidence indicates that cerebral metabolic features, evaluated by proton magnetic resonance spectroscopy ((1) H-MRS), are sensitive to early mitochondrion dysfunction associated with mitochondrial encephalomyopathy (ME). The metabolite ratios of lactate (lac)/Cr, N-acetyl aspartate (NAA)/creatine (Cr), total choline (tCho)/Cr, and myoinositol (mI)/Cr are measured in the infarct-like lesions by (1) H-MRS and may reveal metabolic changes associated with ME. However, the application of this molecular imaging technique in the investigation of the pathology of ME subtypes is unknown...
August 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28535487/nerve-excitability-changes-related-to-muscle-weakness-in-chronic-progressive-external-ophthalmoplegia
#6
Antoine Gueguen, Claude Jardel, Marc Polivka, S Veronica Tan, Françoise Gray, Catherine Vignal, Anne Lombès, Olivier Gout, Hugh Bostock
OBJECTIVE: To explore potential spreading to peripheral nerves of the mitochondrial dysfunction in chronic progressive external ophthalmoplegia (CPEO) by assessing axonal excitability. METHODS: CPEO patients (n=13) with large size deletion of mitochondrial DNA and matching healthy controls (n=22) were included in a case-control study. Muscle strength was quantified using MRC sum-score and used to define two groups of patients: CPEO-weak and CPEO-normal (normal strength)...
July 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28324239/mtdna-maintenance-defects-syndromes-and-genes
#7
Carlo Viscomi, Massimo Zeviani
A large group of mitochondrial disorders, ranging from early-onset pediatric encephalopathic syndromes to late-onset myopathy with chronic progressive external ophthalmoplegia (CPEOs), are inherited as Mendelian disorders characterized by disturbed mitochondrial DNA (mtDNA) maintenance. These errors of nuclear-mitochondrial intergenomic signaling may lead to mtDNA depletion, accumulation of mtDNA multiple deletions, or both, in critical tissues. The genes involved encode proteins belonging to at least three pathways: mtDNA replication and maintenance, nucleotide supply and balance, and mitochondrial dynamics and quality control...
July 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28128857/clinical-biochemical-molecular-and-histological-features-of-65-portuguese-patients-with-mitochondrial-disorders
#8
Simão Cruz, Ricardo Taipa, Célia Nogueira, Cristina Pereira, Lígia S Almeida, Raquel Neiva, Tiago Geraldes, António Guimarães, Manuel Melo-Pires, Laura Vilarinho
INTRODUCTION: Mitochondrial disorders display remarkable genetic and phenotypic heterogeneity. METHODS: We performed a retrospective analysis of the clinical, histological, biochemical, and genetic features of 65 patients with molecular diagnoses of mitochondrial disorders. RESULTS: The most common genetic diagnosis was a single large-scale mitochondrial DNA (mtDNA) deletion (41.5%), and the most frequent clinical phenotype was chronic progressive external ophthalmoplegia (CPEO)...
November 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/27928383/late-onset-development-of-eyelid-ptosis-in-chronic-progressive-external-ophthalmoplegia-a-30-year-follow-up
#9
Jennifer Murdock, Preeti J Thyparampil, Michael T Yen
Chronic progressive external ophthalmoplegia (CPEO) is a mitochondrial myopathy with slowly progressive, often symmetric blepharoptosis and limitation of ocular motility in all directions of gaze. The authors present an unusual case of CPEO that initially presented with the unique features of markedly asymmetric facial weakness and the lack of blepharoptosis. However, over the subsequent three decades, the patient developed progressive facial and eyelid dysfunction more consistent with a classical description of CPEO...
February 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27856367/dysphagia-is-prevalent-in-patients-with-cpeo-and-single-large-scale-deletions-in-mtdna
#10
Gitte Hedermann, Nicoline Løkken, Julia R Dahlqvist, John Vissing
BACKGROUND: The aim of this study was to assess the frequency of subjective and objective dysphagia in patients with chronic progressive external ophthalmoplegia (CPEO) due to single, large-scale deletions (LSDs) of mitochondrial DNA (mtDNA). METHODS: Sixteen patients with CPEO and single LSDs of mtDNA were included in the study and compared to a control group of 12 patients with the m.3243A>G mtDNA mutation. Patients had to drink 80ml of water at 4°C as fast as they could (cold-water test) and fill out a standardized questionnaire about dysphagia...
January 2017: Mitochondrion
https://www.readbyqxmd.com/read/27822509/peripheral-neuropathy-in-patients-with-cpeo-associated-with-single-and-multiple-mtdna-deletions
#11
Diana Lehmann, Malte E Kornhuber, Carolina Clajus, Charlotte L Alston, Andreas Wienke, Marcus Deschauer, Robert W Taylor, Stephan Zierz
OBJECTIVE: To characterize peripheral nerve involvement in patients with chronic progressive external ophthalmoplegia (CPEO) with single and multiple mitochondrial DNA (mtDNA) deletions, based on clinical scores and detailed nerve conduction studies. METHODS: Peripheral nerve involvement was prospectively investigated in 33 participants with CPEO (single deletions n = 18 and multiple deletions n = 15). Clinically, a modified Total Neuropathy Score (mTNS) and a modified International Cooperative Ataxia Rating Scale (mICARS) were used...
December 2016: Neurology. Genetics
https://www.readbyqxmd.com/read/27570648/ion-channel-electrophysiology-ontology-icepo-a-case-study-of-text-mining-assisted-ontology-development
#12
Ravikumar Komandur Elayavilli, Hongfang Liu
BACKGROUND: Computational modeling of biological cascades is of great interest to quantitative biologists. Biomedical text has been a rich source for quantitative information. Gathering quantitative parameters and values from biomedical text is one significant challenge in the early steps of computational modeling as it involves huge manual effort. While automatically extracting such quantitative information from bio-medical text may offer some relief, lack of ontological representation for a subdomain serves as impedance in normalizing textual extractions to a standard representation...
2016: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/27296531/the-phenotypic-spectrum-of-fifty-czech-m-3243a-g-carriers
#13
V Dvorakova, H Kolarova, M Magner, M Tesarova, H Hansikova, J Zeman, T Honzik
BACKGROUND: Mitochondrial myopathy, Encephalopathy, Lactic Acidosis and Stroke-like episodes syndrome (MELAS) is a common mitochondrial disorder with varying multisystemic clinical manifestation. We present a comprehensive clinical picture of 50 Czech m.3243A>G carriers with emphasis on the sequence of symptoms in symptomatic patients. RESULTS: Symptoms developed in 33 patients (66%) and 17 carriers remained unaffected (34%). The age of onset varied from 1month to 47years of age, with juvenile presentation occurring in 53% of patients...
August 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27111092/chronic-progressive-external-ophthalmoplegia-in-the-absence-of-ptosis
#14
Robert C Bucelli, Michael S Lee, Collin M McClelland
Classically defined as bilateral, symmetric, and progressive ophthalmoparesis with myopathic ptosis, chronic progressive external ophthalmoplegia (CPEO) rarely has been reported in the absence of ptosis. We describe 2 patients with CPEO and without ptosis who presented with binocular diplopia related to small-angle esodeviations, poor fusional amplitudes, and slow saccades. In both cases, hematological studies and neuroimaging ruled out alternative etiologies, whereas muscle biopsy showed findings of mitochondrial myopathy...
September 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27029465/ophthalmological-findings-in-74-patients-with-mitochondrial-disease
#15
Cheng-Cheng Zhu, Elias I Traboulsi, Sumit Parikh
BACKGROUND: Mitochondrial disease often manifests with ophthalmologic signs and symptoms. Due to the important role of mitochondria in aerobic metabolism, the eyes are among the more preferentially involved organs. The clinical diagnosis of mitochondrial disease can be facilitated by an improved knowledge of the types and magnitude of their various manifestations. The aim of this study was to describe the ophthalmological manifestations of patients with mitochondrial diseases that are currently not well elucidated...
January 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/27014581/a-novel-mitochondrial-trna-ala-gene-variant-causes-chronic-progressive-external-ophthalmoplegia-in-a-patient-with-huntington-disease
#16
Massimiliano Filosto, Gaetana Lanzi, Claudia Nesti, Valentina Vielmi, Eleonora Marchina, Anna Galvagni, Silvia Giliani, Filippo M Santorelli, Alessandro Padovani
Chronic progressive external ophthalmoplegia is a mitochondrial disorder usually caused by single or multiple mitochondrial DNA (mtDNA) deletions and, more rarely, by maternally inherited mtDNA point mutations, most frequently in tRNA genes (MTT). We report on a patient presenting with a progressive eyelid ptosis with bilateral ophthalmoparesis, dysphagia, dysphonia and mild proximal limb weakness associate with a mild movement disorder characterized by abnormal involuntary movements involving head and limbs, imbalance and gait instability...
March 2016: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/27014580/the-expanding-phenotype-of-melas-caused-by-the-m-3291t%C3%A2-%C3%A2-c-mutation-in-the-mt-tl1-gene
#17
E Keilland, C A Rupar, Asuri N Prasad, K Y Tay, A Downie, C Prasad
m.3291T > C mutation in the MT-TL1 gene has been infrequently encountered in association with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), however remains poorly characterized from a clinical perspective. In the following report we describe in detail the phenotypic features, long term follow up (> 7 years) and management in a Caucasian family with MELAS due to the m.3291T > C mutation and review the literature on m.3291T > C mutation. The clinical phenotype in the proposita included overlapping features of MELAS, MERRF (Myoclonic epilepsy and ragged-red fiber syndrome), MNGIE (Mitochondrial neurogastrointestinal encephalopathy), KSS (Kearns-Sayre Syndrome) and CPEO (Chronic progressive external ophthalmoplegia)...
March 2016: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/26689116/novel-mutation-in-c10orf2-associated-with-multiple-mtdna-deletions-chronic-progressive-external-ophthalmoplegia-and-premature-aging
#18
Arumugam Paramasivam, Angamuthu Kannan Meena, Lalitha Pedaparthi, Vuskamalla Jyothi, Megha S Uppin, Shaikh Afshan Jabeen, Challa Sundaram, Kumarasamy Thangaraj
Chronic progressive external ophthalmoplegia (CPEO) is caused by defects in both mitochondrial and nuclear genes, however, the causal genetic factors in large number of patients remains undetermined. Therefore, our aim was to screen 12 unrelated patients with CPEO for mutation/multiple deletions in mtDNA and mutations in the coding regions of C10orf2, which is essential for mtDNA replication. Histopathological study of muscle biopsy revealed cytochrome c oxidase-deficient fibers and ragged blue fibers in all the patients...
January 2016: Mitochondrion
https://www.readbyqxmd.com/read/26214044/analysis-of-mitochondrial-network-morphology-in-cultured-myoblasts-from-patients-with-mitochondrial-disorders
#19
J Sládková, J Spáčilová, M Čapek, M Tesařová, H Hansíková, T Honzík, J Martínek, J Zámečník, O Kostková, J Zeman
Mitochondrial morphology was studied in cultivated myoblasts obtained from patients with mitochondrial disorders, including CPEO, MELAS and TMEM70 deficiency. Mitochondrial networks and ultrastructure were visualized by fluorescence microscopy and transmission electron microscopy, respectively. A heterogeneous picture of abnormally sized and shaped mitochondria with fragmentation, shortening, and aberrant cristae, lower density of mitochondria and an increased number of "megamitochondria" were found in patient myoblasts...
2015: Ultrastructural Pathology
https://www.readbyqxmd.com/read/26094573/rnaseh1-mutations-impair-mtdna-replication-and-cause-adult-onset-mitochondrial-encephalomyopathy
#20
Aurelio Reyes, Laura Melchionda, Alessia Nasca, Franco Carrara, Eleonora Lamantea, Alice Zanolini, Costanza Lamperti, Mingyan Fang, Jianguo Zhang, Dario Ronchi, Sara Bonato, Gigliola Fagiolari, Maurizio Moggio, Daniele Ghezzi, Massimo Zeviani
Chronic progressive external ophthalmoplegia (CPEO) is common in mitochondrial disorders and is frequently associated with multiple mtDNA deletions. The onset is typically in adulthood, and affected subjects can also present with general muscle weakness. The underlying genetic defects comprise autosomal-dominant or recessive mutations in several nuclear genes, most of which play a role in mtDNA replication. Next-generation sequencing led to the identification of compound-heterozygous RNASEH1 mutations in two singleton subjects and a homozygous mutation in four siblings...
July 2, 2015: American Journal of Human Genetics
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