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https://www.readbyqxmd.com/read/29328619/characterization-of-the-polyspecific-transferase-of-murine-type-i-fatty-acid-synthase-fas-and-implications-for-polyketide-synthase-pks-engineering
#1
Alexander Rittner, Karthik S Paithankar, Khanh Vu Huu, Martin Grininger
Fatty acid synthases (FASs) and polyketide synthases (PKSs) condense acyl compounds to fatty acids and polyketides, respectively. Both, FASs and PKSs, harbor acyltransferases (ATs), which select substrates for condensation by β-ketoacyl synthases (KSs). Here, we present the structural and functional characterization of the polyspecific malonyl/acetyltransferase (MAT) of murine FAS. We assign kinetic constants for the transacylation of the native substrates, acetyl- and malonyl-CoA, and demonstrate the promiscuity of FAS to accept structurally and chemically diverse CoA-esters...
January 12, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29326531/medial-pivot-in-total-knee-arthroplasty-literature-review-and-our-first-experience
#2
REVIEW
Luigi Sabatini, Salvatore Risitano, Gennaro Parisi, Ferdinando Tosto, Pier Francesco Indelli, Francesco Atzori, Alessandro Massè
Background: Traditional total knee implants designs, usually, are not able to reproduce the physiological kinematics of the knee, leaving almost 20% of the patients, those who underwent a total knee arthroplasty (TKA), not fully satisfied. Modern inserts are nowadays designed with a fully congruent medial compartment to reproduce the normal medial pivoting biomechanics of the knee. The aim of this article was to evaluate preliminary clinical improvement using the Medial Congruent (MC) insert as specific level of constraint...
2018: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29325835/synthetic-mesh-vs-allograft-extensor-mechanism-reconstruction-in-total-knee-arthroplasty-a-systematic-review-of-the-literature-and-meta-analysis
#3
REVIEW
David Shau, Ryan Patton, Suhag Patel, Laura Ward, George Guild
BACKGROUND: Extensor mechanism disruption after total knee arthroplasty (TKA) is a devastating complication. Reconstruction with allograft and synthetic mesh has been described. However, these reports have typically been small case series, and controversy exists with regard to which reconstruction technique is optimal. METHODS: The authors performed a systematic review using PUBMED, MEDLINE, EMBASE, BIOSIS, Clinicaltrials.gov, and Cochrane Database of Systematic Reviews identifying 14 articles meeting inclusion criteria and producing 204 knees for comparison...
January 8, 2018: Knee
https://www.readbyqxmd.com/read/29310369/mitochondrial-mutations-in-12s-rrna-and-16s-rrna-presenting-as-chronic-progressive-external-ophthalmoplegia-cpeo-plus-a-case-report
#4
Zhan-Yun Lv, Xue-Mei Xu, Xiao-Fu Cao, Qian Wang, Da-Fang Sun, Wen-Jing Tian, Yan Yang, Yu-Zhong Wang, Yan-Lei Hao
RATIONALE: Chronic progressive external ophthalmoplegia (CPEO) is a classical mitochondrial ocular disorder characterized by bilateral progressive ptosis and ophthalmoplegia. Kearns -Sayre syndrome (KSS) is a multisystem disorder with PEO, cardiac conduction block, and pigmentary retinopathy. A few individuals with CPEO have other manifestations of KSS, but do not meet all the clinical diagnosis criteria, and this is called "CPEO plus." PATIENT CONCERNS: We report a 48-year-old woman exhibiting limb weakness, ptosis, ophthalmoparesis, and cerebellar dysfunctions...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29306499/an-alternative-treatment-for-osteoporotic-su-type-iii-periprosthetic-supracondylar-femur-fractures-double-locking-plate-fixation
#5
Hakan Çiçek, Ümit Tuhanioğlu, Hasan Ulaş Oğur, Fırat Seyfettinoğlu, Murat Bozkurt
INTRODUCTION: Patients with Su Type III fractures based on total knee arthroplasty (TKA) constitute a patient group with problematic treatment and management. Although it has difficulties, open reduction and internal fixation is one of the treatment options. METHOD: A retrospective evaluation was made of 22 patients surgically treated in our clinic with double locking, low contact titanium plate and screw for a Su Type III periprosthetic fracture based on TKA. The patients were evaluated with bone mineral densitometry, postoperative Knee Society Score (KSS), WOMAC and radiological evaluations...
January 3, 2018: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29299474/improvement-in-hamstring-and-quadriceps-muscle-strength-following-cruciate-retaining-single-radius-total-knee-arthroplasty
#6
Jennifer Kurowicki, Anton Khlopas, Assem A Sultan, Nipun Sodhi, Linsen T Samuel, Morad Chughtai, Martin Roche, Peter M Bonutti, Michael A Mont
Background: The ability to reach full functional capacity following total knee arthroplasty (TKA) is reliant on the strength of the quadriceps and hamstring muscles. Weakness of these muscles can persist anywhere from 1 to 3 years post-operatively. There remains considerable controversy as to what factors influence restoration of muscle strength after TKA. Implant designs have been implicated in the ability of patients to recover. Currently there is a paucity of literature available describing the influence of patient characteristics, surgical factors, and clinical outcomes on quadriceps and hamstring muscle strength following TKA with a cruciate-retaining, single radius (SR) implant...
December 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29281091/self-reported-drowsiness-and-safety-outcomes-while-driving-after-an-extended-duration-work-shift-in-trainee-physicians
#7
Clare Anderson, Suzanne Ftouni, Joseph M Ronda, Shantha M W Rajaratnam, Charles A Czeisler, Steven W Lockley
Objectives: Extended duration (≥24 h) work shifts (EDWS) are associated with increased risk of motor vehicle crashes, and awareness of any impairment has important implications on legal accountability for any adverse driving outcome. The extent to which adverse driving events were preceded by pre-drive self -reported sleepiness was evaluated in medical residents after EDWS. Methods: Sixteen resident physicians (10F;29.2±2.0y) working EDWS were monitored when driving on their commute to and from the hospital (438 drives)...
December 22, 2017: Sleep
https://www.readbyqxmd.com/read/29274863/total-knee-arthroplasty-with-the-medial-pivot-knee-system-clinical-and-radiological-outcomes-at-9-5-years-mean-follow-up
#8
M Dehl, Y Bulaïd, M Chelli, B Ramy, A Gabrion, E Havet, P Mertl
INTRODUCTION: The "ball-in-socket" design of the Medial-Pivot Knee System (MicroPort Orthopedics, Arlington, Tennessee, USA) aims to reproduce normal knee kinematics by medializing its rotational axis. The goal of this study was to measure knee range of motion (ROM) with this implant after a mean follow-up of 10 years and to report the survivorship and long-term clinical and radiological outcomes. We hypothesized the prosthetic knee would have at least 120 flexion at 10 years. MATERIAL AND METHODS: This was retrospective, single-centre study of 74 Medial-Pivot knees implanted in 71 patients (average age of 69 years) between May 2005 and November 2007...
December 21, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29273898/pseudo-patella-baja-a-minor-yet-frequent-complication-of-total-knee-arthroplasty
#9
Giulia Bugelli, Francesco Ascione, Niki Cazzella, Edoardo Franceschetti, Francesco Franceschi, Giacomo Dell'Osso, Eleonor Svantesson, Kristian Samuelsson, Stefano Giannotti
PURPOSE: One of the complications in total knee arthroplasty (TKA) is pseudo-patella baja (PPB). PPB is present when there is no shortening of the patellar tendon, but the joint line is elevated. The purpose of this study is to investigate the incidence of PPB after TKA and its clinical effects. METHODS: A case series of 158 patients undergoing TKA surgery between 1999 and 2012 at the 2nd Department of Orthopaedics and Traumatology, Pisa were retrospectively reviewed...
December 23, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29247814/clinical-application-of-different-operative-approach-of-total-knee-replacement-in-knee-valgus-patients-retrospective-cohort-study
#10
Chong-Jun Guo, Jun Liu, Dong-Sheng Niu, Jun Ma, Bo Kou, Hai-Jiao Zhang, Shao-Wei Xu, Xiao-Di Mu, Lv-Lin Yang, Hua Zhang
PURPOSE: According to the severity of knee valgus, different operative approaches were applied in total knee replacement. Hence, we assessed the safety and efficacy of different operative approaches in the level IV study. METHODS: From May 2011 to March 2014, a retrospectively analysis was conducted among 31 patients with knee valgus (mild in 10 cases, moderate in 8 cases and severe in 13 cases based on Keblish grade). Medial approach trip knee replacement was performed in mild and moderate patients, which were assigned as medial approach group...
December 13, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29247357/tibial-internal-rotation-negatively-affects-clinical-outcomes-in-total-knee-arthroplasty-a-systematic-review
#11
REVIEW
Alfredo Schiavone Panni, Francesco Ascione, Marco Rossini, Adriano Braile, Katia Corona, Michele Vasso, Michael T Hirschmann
PURPOSE: The aim of this systematic review is to analyze the effect of tibial rotational alignment after total knee arthroplasty (TKA) on clinical outcomes and assess the eventual cut-off values for tibial TKA rotation leading to poor outcomes. METHODS: A detailed and systematic search from 1997 to 2017 of the Pubmed, Medline, Cochrane Reviews, and the Google Scholar databases was performed using the keyword terms "total knee arthroplasty", "total knee replacement", "tibial alignment", "tibial malalignement", "tibial rotation", "rotational error", "axis", "angle", "tibial malrotation", "clinical outcome", in several combinations...
December 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29245293/association-of-tourniquet-utilization-with-blood-loss-rehabilitation-and-complications-in-chinese-obese-patients-undergoing-total-knee-arthroplasty-a-retrospective-study
#12
Zhirui Li, Daohong Liu, Gong Long, Gong Ke, An Xiao, Peifu Tang, Jiyuan Dong
Obesity not only gives rise to more blood loss volume but also correlates with postoperative rehabilitation and complications in surgical patients. It is not clear at present whether tourniquet utilization is associated with blood loss, rehabilitation, and complications, and it is imperative to ascertain the tactics of utilizing tourniquet in obese patients undergoing total knee arthroplasty (TKA). The present study was designed to explore the association of tourniquet utilization with blood loss, rehabilitation, and complications, and ascertain the tactics of utilizing tourniquet in obese patients undergoing TKA...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29243283/intra-articular-injection-of-autologous-adipose-derived-mesenchymal-stem-cells-in-treatment-of-knee-osteoarthritis
#13
Duško Spasovski, Vesna Spasovski, Zoran Baščarević, Maja Stojiljković, Miša Vreća, Marina Andjelković, Sonja Pavlović
BACKGROUND: Osteoarthritis (OA) is a chronic degenerative joint disease, considered to be the fourth leading cause of disability and the second cause of inability to work in men. Recently, adipose derived mesenchymal stem cells (AD-MSCs) came in focus of regenerative medicine as promising tool for treatment of OA. It has been shown that administration of stem cells into impaired joints results in pain relief and improves quality of life, accompanied with restoration of hyaline articular cartilage...
December 15, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29233240/sleep-on-long-haul-layovers-and-pilot-fatigue-at-the-start-of-the-next-duty-period
#14
Jan Cosgrave, Lora J Wu, Margo van den Berg, T Leigh Signal, Philippa H Gander
INTRODUCTION: Layovers are critical for pilot recovery between flights and minimum layover durations are required by regulation. However, research on the factors affecting layover sleep and safety performance indicators (SPIs) before subsequent flights is relatively sparse. The present project combined data from 6 studies, including 8 long-range and 5 ultra-long range out-and-back trips across a range of different layover destinations (299 pilots in 4-person crews, 410 layovers, 1-3 d layover duration)...
January 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29223709/bone-marrow-edema-syndrome-of-the-medial-femoral-condyle-treated-with-extracorporeal-shock-wave-therapy-a-clinical-and-mri-retrospective-comparative-study
#15
Matteo Vitali, Nadim Naim Rodriguez, Alberto Pedretti, Andreas Drossinos, Pierluigi Pironti, Gaia Di Carlo, Gianfranco Fraschini
OBJECTIVE: To determine the validity of Extracorporeal Shock Wave Therapy (ESWT) in the treatment of Bone Marrow Edema (BME) of the medial condyle of the knee DESIGN: Retrospective STUDY SETTING: IRCCS San Raffaele Hospital, Orthopedics Outpatient Clinic PARTICIPANTS: Fifty-six symptomatic patients affected by bone marrow edema of the medial condyle of the knee. Patients were equally divided in a ESWT (Extracorporeal Shock Wave Therapy) treated group and a control group, which was managed conservatively...
December 6, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29205992/curative-effect-of-knee-arthroplasty-on-patients-with-osteoarthritis-and-analysis-of-long-term-joint-function-of-these-patients
#16
Xianxun Wang, Lin Cai
BACKGROUND: We aimed to explore the curative effect of knee arthroplasty on patients with osteoarthritis and analysis of their long-term joint function. METHODS: 96 cases of osteoarthritis patients, collected in our hospital from June 2010 to May 2011, were divided into control group and observation group (n=48, each group). Patients in observation group were treated by knee replacement, and patients in control group were treated by arthroscopic debridement. Bleeding during operation of patients and the operation time in both groups were comparable during their followed up for 6~60 months, with an average of 52 months...
December 4, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/29201304/minimally-invasive-plate-osteosynthesis-using-a-screw-compression-method-for-treatment-of-humeral-shaft-fractures
#17
Sang-Hun Ko, Jae-Ryong Cha, Chae Chil Lee, Yong Tae Joo, Kyeong Su Eom
Background: This study aims to compare the surgical outcomes of open reduction and internal fixation (ORIF) and minimally invasive plate osteosynthesis (MIPO) using a screw compression method in simple humeral shaft fractures. Methods: This retrospective study was performed with 50 patients who had surgical interventions for the treatment of simple humeral shaft fractures and had follow-ups of at least 12 months in Ulsan University Hospital between August 2008 and June 2015...
December 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/29199379/mini-subvastus-versus-medial-parapatellar-approach-for-total-knee-arthroplasty-a-prospective-randomized-controlled-study
#18
Ziyu Li, Wendan Cheng, Liangye Sun, Yunfeng Yao, Qiliang Cao, Shuming Ye, Lei Qi, Shenglin Xu, Xiaosan Wu, Juehua Jing
PURPOSE: Whether minimally invasive total knee arthroplasty (MIS-TKA) could offer better and faster recovery without the deviation of post-operative prosthesis position and limb alignment is still controversial. This prospective and randomized study was conducted to compare the clinical and radiological outcomes between patients who underwent the mini-subvastus approach of MIS-TKA and those who underwent the medial parapatellar approach of traditional TKA. METHODS: Fifty patients, including 50 knees, who required TKA due to osteoarthritis were randomized to the mini-subvastus group (group I) or the medial parapatellar group (group II)...
December 4, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29198374/surgically-treated-hoffa-fractures-with-poor-long-term-functional-results
#19
Tolga Onay, Deniz Gülabi, İlker Çolak, Güven Bulut, Seyit Ali Gümüştaş, Gültekin Sıtkı Çeçen
INTRODUCTION: Hoffa fractures are rare injuries and usually involve the lateral condyle. There are few published studies of large series of isolated coronal plane fractures of the femoral condyle. The aim of the study to determine the long-term functional outcomes and complications in surgically treated Hoffa fractures. PATIENTS AND METHODS: A retrospective review was made of 13 consecutive patients who were treated surgically for an isolated coronal plane fracture of the distal femur posterior condyle...
November 24, 2017: Injury
https://www.readbyqxmd.com/read/29188334/increased-in-vivo-patellofemoral-loading-after-total-knee-arthroplasty-in-resurfaced-patellae
#20
Omer Slevin, Florian A Schmid, Filippo Schiapparelli, Helmut Rasch, Michael T Hirschmann
PURPOSE: The primary purpose of the study was to investigate if and how patellar bone tracer uptake (BTU) distribution in SPECT/CT is influenced by patellar resurfacing and the position of femoral and tibial TKA component position. METHODS: A total of 104 knees of 103 consecutive patients who underwent primary TKA were prospectively investigated. Primary patellar resurfacing was done in 40 knees while 64 had a TKA without patellar resurfacing. All patients underwent clinical assessment using the knee society score (KSS) and standardized radiographs and Tc-99m-HDP-SPECT/CT before and 12 and 24 months after TKA...
November 29, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
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