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https://www.readbyqxmd.com/read/27920791/extending-a-single-residue-switch-for-abbreviating-catalysis-in-plant-ent-kaurene-synthases
#1
Meirong Jia, Reuben J Peters
Production of ent-kaurene as a precursor for important signaling molecules such as the gibberellins seems to have arisen early in plant evolution, with corresponding cyclase(s) present in all land plants (i.e., embryophyta). The relevant enzymes seem to represent fusion of the class II diterpene cyclase that produces the intermediate ent-copalyl diphosphate (ent-CPP) and the subsequently acting class I diterpene synthase that produces ent-kaurene, although the bifunctionality of the ancestral gene is only retained in certain early diverging plants, with gene duplication and sub-functionalization leading to distinct ent-CPP synthases and ent-kaurene synthases (KSs) generally observed...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27909123/comparative-study-of-computer-assisted-total-knee-arthroplasty-after-opening-wedge-osteotomy-versus-after-unicompartmental-arthroplasty
#2
R Pailhé, J Cognault, J Massfelder, A Sharma, R-C Rouchy, B Rubens-Duval, D Saragaglia
AIMS: The role of high tibial osteotomy (HTO) is being questioned by the use of unicompartmental knee arthroplasty (UKA) in the treatment of medial compartment femorotibial osteoarthritis. Our aim was to compare the outcomes of revision HTO or UKA to a total knee arthroplasty (TKA) using computer-assisted surgery in matched groups of patients. PATIENTS AND METHODS: We conducted a retrospective study to compare the clinical and radiological outcome of patients who underwent revision of a HTO to a TKA (group 1) with those who underwent revision of a medial UKA to a TKA (group 2)...
December 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27907935/a-meta-analysis-of-functional-outcomes-in-patient-specific-instrumented-knee-arthroplasty
#3
Ashim Mannan, Deji Akinyooye, Fahad Hossain
Alignment data in patient-specific instrumented (PSI) knee arthroplasty have been examined in several meta-analyses, with demonstration of comparative but not improved restitution of a neutral mechanical axis and favorable outcomes in femoral implant axial alignment. To date, no comprehensive synthesis of data has been conducted specifically for functional outcomes. Relevant databases were searched according to Preferred Reporting Items for Systematic reviews and Meta-analyses guidelines during the period 2000 to 2015 of Levels 1 and 2 studies comparing functional outcomes of patient-specific instrumentation (PSI) versus conventional instrumentation...
December 1, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27904951/pre-emptive-injection-of-peri-articular-multimodal-drug-for-post-operative-pain-management-in-total-knee-arthroplasty-a-double-blind-randomized-clinical-trial
#4
Mahdi Motififard, Ali Omidian, Sajad Badiei
PURPOSE: Severe post-operative pain is one of the main problems after total knee arthroplasty. In this study, we investigated the effect of a peri-articular multimodal drugs injections pre-emptively on post-operative pain control and knee functions following total knee arthroplasty. METHODS AND MATERIALS: This study was a double-blind randomized clinical trial. Eligible cases including 137 patients-aged 30 to 80 years old-were randomly divided into one of two groups: the drug group received a cocktail consisting of bupivacaine hydrochloride, morphine sulphate, epinephrine, and ketorolac...
November 30, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27904719/does-cruciate-retaining-total-knee-arthroplasty-show-better-quadriceps-recovery-than-posterior-stabilized-total-knee-arthroplasty-objective-measurement-with-a-dynamometer-in-102-knees
#5
Kye-Youl Cho, Kang-Il Kim, Sang-Jun Song, Dae-Kyung Bae
BACKGROUND: Cruciate-retaining (CR) prostheses have been considered to produce more physiologic femoral rollback, provide better proprioception, and result in better quadriceps recovery than posterior-stabilized (PS) prostheses after total knee arthroplasty (TKA). However, there are very few studies demonstrating these benefits in an objective manner. We investigated whether CR-TKA could result in (1) better quadriceps recovery; (2) a greater proportion of patients with beyond the preoperative level of recovery; and (3) better clinical outcomes than PS-TKA...
December 2016: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/27904221/what-have-we-learned-from-100-success-of-press-fit-condylar-rotating-platform-posterior-stabilized-knees-a-5-10-years-followup-by-a-nondesigner
#6
Shrinand V Vaidya, Siddharth Virani, Rajendra Phunde, Abhishek Mahajan
BACKGROUND: Total joint arthroplasties of the hip and knee represent a remarkable feat of modern medicine in terms of reducing pain and restoring function to millions of patients afflicted with severe arthritis. Oftentimes, the performance and longevity of new implants and devices are based on limited data. This is the first study by a non-designer on the press fit condylar rotating platform posterior stabilized (PFC-RP-PS) design with 100' success. This has a relevance, vis-á -vis bias that one may have in terms of reproducibility of technique and funding from the manufacturer...
November 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27902352/cohnella-lubricantis-sp-nov-isolated-from-a-coolant-lubricant-solution
#7
Peter Kämpfer, Stefanie P Glaeser, Hans-Jürgen Busse
A Gram-staining-positive, aerobic, non-endospore forming organism, isolated from a coolant lubricant solution was studied for its taxonomic position. On the basis of 16S rRNA gene sequence similarity comparisons, strain KSS-154-50T was grouped into the genus Cohnella, most closely related to Cohnella formosensis ALFALFA-35T (97.3 %), Cohnella rhizosphaerae CSE-5610T (97.1 %) and Cohnella nanjingensis D-45T (97.0%). The 16S rRNA gene sequence similarity to other Cohnella species was < 97.0 %. The fatty acid profile from whole cell hydrolysates was very similar to those reported for other Cohnella species supported the allocation to the genus Cohnella...
November 9, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27894876/long-term-functional-outcomes-after-primary-surgical-repair-of-acute-and-chronic-patellar-tendon-rupture-series-of-25%C3%A2-patients
#8
K Belhaj, H El Hyaoui, A Tahir, S Meftah, L Mahir, A Rafaoui, F Lmidmani, M Arsi, M Rahmi, M Rafai, A Garch, M Fadili, M Nechad, A El Fatimi
OBJECTIVE: We aimed to evaluate the clinical outcomes after surgical repair of patellar tendon rupture (PTR) and compare the evolution of 2 types of rupture (acute and chronic) after the same rehabilitation protocol. METHODS: This was a prospective cohort study of patients with PTR treated between January 2006 and January 2014 in the department of trauma surgery, Ibn Rochd university hospital, Casablanca. RESULTS: We evaluated 25 patients (21 men) after a median follow-up of 75 months (range 29-120)...
November 25, 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27882399/-circadian-rhythm-influence-on-epworth-sleepiness-scale-score
#9
M Herzog, A Bedorf, C Rohrmeier, T Kühnel, B Herzog, T Bremert, S Plontke, S Plößl
BACKGROUND: The Epworth Sleepiness Scale (ESS) is frequently used to determine daytime sleepiness in patients with sleep-disordered breathing. It is still unclear whether different levels of alertness induced by the circadian rhythm influence ESS score. OBJECTIVE: The aim of this study is to investigate the influence of circadian rhythm-dependent alertness on ESS performance. MATERIALS AND METHODS: In a monocentric prospective noninterventional observation study, 97 patients with suspected sleep-disordered breathing were investigated with respect to daytime sleepiness in temporal relationship to polysomnographic examination and treatment...
November 23, 2016: HNO
https://www.readbyqxmd.com/read/27876266/knee-arthrodesis-by-the-ilizarov-method-in-the-treatment-of-total-knee-arthroplasty-failure
#10
Andrea Antonio Maria Bruno, Alexander Kirienko, Andrea Peccati, Paolo Dupplicato, Massimo De Donato, Enrico Arnaldi, Nicola Portinaro
BACKGROUND: Currently, the main indication for knee arthrodesis is septic failure of a total knee arthroplasty (TKA). The purpose of this study was to evaluate the results of knee arthrodesis by circular external fixation performed in the treatment of TKA failure in which revision arthroplasty was not indicated. METHODS: The study involved 19 patients who underwent knee arthrodesis by the Ilizarov method. Clinical and functional assessments were performed, including Knee Society Score (KSS)...
November 18, 2016: Knee
https://www.readbyqxmd.com/read/27846356/-cemented-stems-in-revision-total-knee-arthroplasty-on-patients-older-than-75-y-o-clinical-and-radiological-analysis
#11
L Baggio, S Gil-González, X Barra-González, F Collado-Saenz, E Cruz-Olive
BACKGROUND: The purpose of this study was to analyze the clinical and radiological evolution of the total knee revision arthroplasty with cemented stems in patients over 75 years. MATERIAL AND METHODS: A retrospective analysis was performed in all the subjects who underwent revision of total knee arthroplasty with cemented stems between 2008 and 2014 in our center. Twenty-seven individuals over 75 years met the inclusion criteria. We assessed the Knee Society Score and range of motion for clinical outcome...
March 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/27824380/double-pass-retina-point-imaging-for-the-evaluation-of-optical-light-scatter-retinal-image-quality-and-staging-of-keratoconus
#12
Anthony P Leonard, Scott D Gardner, Karolinne M Rocha, Evan R Zeldin, David M Tremblay, George O Waring
PURPOSE: To measure retinal image quality using point spread function (PSF) analysis by double-pass retina point imaging in patients with keratoconus and to correlate visual quality with disease severity. METHODS: Patients diagnosed as having keratoconus by clinical examination, topography, and tomography and normal eyes were included in this study. A commercially available double-pass retina point imaging instrument (OQAS 108 II AcuTarget HD; Visiometrics S.L., Terrassa, Spain) was used to collect Objective Scatter Index (OSI) values in 21 keratoconic and 22 normal eyes...
November 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27816011/sleep-alertness-and-alertness-management-among-commercial-airline-pilots-on-short-haul-and-long-haul-flights
#13
Mikael Sallinen, Maria Sihvola, Sampsa Puttonen, Kimmo Ketola, Antti Tuori, Mikko Härmä, Göran Kecklund, Torbjörn Åkerstedt
Airline pilots' sleep and on-duty alertness are important focus areas in commercial aviation. Until now, studies pertaining to this topic have mainly focused on specific characteristics of flights and thus a comprehensive picture of the matter is not well established. In addition, research knowledge of what airline pilots actually do to maintain their alertness while being on duty is scarce. To address these gaps in research knowledge, we conducted a field study on a representative sample of the airline pilots of a medium-sized airline...
November 2, 2016: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/27815584/surgical-options-for-chronic-patellar-tendon-rupture-in-total-knee-arthroplasty
#14
Alfredo Lamberti, Giovanni Balato, Pier Paolo Summa, Ashok Rajgopal, Attique Vasdev, Andrea Baldini
PURPOSE: The purpose of this study was to compare mid-term results of three different reconstructive techniques for chronic patellar tendon disruption after total knee arthroplasty (TKA). Several surgical techniques have been proposed, but to date it is still unclear which is the best solution. The hypothesis was that allografts provide better functional results than autografts in restoring a correct joint function. METHODS: Twenty-one reconstructions were performed in twenty-one patients (three groups of seven patients) with chronic patellar tendon lesion following TKA...
November 5, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27802922/subjective-evaluation-before-and-after-total-knee-arthroplasty-using-the-2011-knee-society-score
#15
Yuichi Kuroda, Tomoyuki Matsumoto, Koji Takayama, Kazunari Ishida, Ryosuke Kuroda, Masahiro Kurosaka
BACKGROUND: Patient satisfaction has been recognized as an important evaluation of total knee arthroplasty (TKA). Therefore, the 2011 Knee Society Knee Scoring System (2011 KSS) was developed in order to quantify patient satisfaction, expectations, and physical activities following TKA. However, very few reports have described subjective evaluation before TKA using the 2011 KSS, as the scoring system is still relatively new. Therefore, the degree of improvement and change over time after TKA has not been evaluated...
December 2016: Knee
https://www.readbyqxmd.com/read/27785555/clinical-and-radiologic-outcomes-of-arthroscopic-suture-bridge-repair-for-the-greater-tuberosity-fractures-of-the-proximal-humerus
#16
Jong-Hun Ji, Jae-Jung Jeong, Young-Yul Kim, Se-Won Lee, Do-Yeol Kim, Sang-Eun Park
PURPOSE: To report the clinical and radiological outcomes of arthroscopic suture bridge repair for the GT fractures of the shoulder joint. METHODS: From March 2008 to July 2013, we performed arthroscopic suture bridge repair of the GT fractures displaced more than 5 mm superiorly or posteriorly, but less than 2 cm in 40 cases [20 men, 20 women; mean age, 56 (27-80) years] with the average 32 (24-48) months follow-up. At the final follow-up, clinical (ASES, UCLA, SST, KSS score and range of motions) and radiological outcomes using post-operative MRI or CT scan were evaluated...
October 26, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27766408/the-effect-of-tourniquet-and-knee-position-during-wound-closure-after-total-knee-arthroplasty-on-early-recovery-of-range-of-motion-a-prospective-randomized-study
#17
Erhan Şükür, Yusuf Öztürkmen, Yunus Emre Akman, Ahmet Senel, İbrahim Azboy
INTRODUCTION: There is no consensus on the position of the knee joint while performing wound closure after total knee arthroplasty (TKA). Further, there are no studies focusing on the association between early functional outcomes and different wound closure strategies. Therefore, we investigated the effects of tourniquet and knee position during wound closure on early recovery of range of motion (ROM) after primary TKA. To our knowledge, this is the first study to evaluate the influence of both tourniquet and knee position during wound closure in primary TKA...
December 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27735047/semitendinosus-and-gracilis-transfer-for-treatment-of-medial-collateral-ligament-injury-of-total-knee-arthroplasty
#18
J-G Cao, L Wang, H-W Zhao, J Liu
OBJECTIVE: The objective of the study is to evaluate the clinic effectiveness of semitendinosus and gracilis transfer for the treatment of medial collateral ligament (MCL) injury of total knee arthroplasty (TKA). PATIENTS AND METHODS: From March 2009 to May 2014, a series of 11 patients with MCL injuries of primary TKA were treated by semitendinosus and gracilis transfer. Another 18 patients (21 knees) were recruited as control group. The two groups of patients were comparable for gender, age, body mass index, varus knee deformity, KSS score, joint activity degree and type of prosthesis comparison without significant difference (p > 0...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27718492/efficacy-of-growth-hormone-therapy-in-kearns-sayre-syndrome-the-kigs-experience
#19
Jose Bernardo Quintos, Juanita K Hodax, Bryn A Gonzales-Ellis, Chanika Phornphutkul, Michael P Wajnrajch, Charlotte M Boney
Kearns-Sayre syndrome (KSS) is characterized by external ophthalmoplegia, retinal pigmentation and cardiac conduction defects due to mitochondrial DNA (mtDNA) deletions. Short stature and growth hormone (GH) deficiency have been reported in KSS, but data on GH treatment is limited. We describe the clinical presentation, phenotype evolution, and response to GH in a patient with KSS and report data on eight additional KSS patients from the KIGS database. Our patient with KSS and GH deficiency achieved a final adult height at -0...
October 8, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27715324/social-jetlag-affects-subjective-daytime-sleepiness-in-school-aged-children-and-adolescents-a-study-using-the-japanese-version-of-the-pediatric-daytime-sleepiness-scale-pdss-j
#20
Yoko Komada, Raoul Breugelmans, Christopher L Drake, Shun Nakajima, Norihisa Tamura, Hideki Tanaka, Shigeru Inoue, Yuichi Inoue
The aim of this study was to elucidate the level of daytime sleepiness in Japanese school-aged children and adolescents, and to examine associated factors including sleep loss and social jetlag using the Japanese version of the Pediatric Daytime Sleepiness Scale (PDSS-J). After the linguistic validation of the PDSS-J with a multi-step translation methodology, consisting of forward translation, back translation, expert review and cognitive debriefing interviews, we conducted a psychometric validation for 492 students aged 11-16 years (46...
2016: Chronobiology International
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