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https://www.readbyqxmd.com/read/28443128/physiological-and-molecular-characterization-of-hydroxyphenylpyruvate-dioxygenase-hppd-inhibitor-resistance-in-palmer-amaranth-amaranthus-palmeri-s-wats
#1
Sridevi Nakka, Amar S Godar, Prashant S Wani, Curtis R Thompson, Dallas E Peterson, Jeroen Roelofs, Mithila Jugulam
Herbicides that inhibit hydroxyphenylpyruvate dioxygenase (HPPD) such as mesotrione are widely used to control a broad spectrum of weeds in agriculture. Amaranthus palmeri is an economically troublesome weed throughout the United States. The first case of evolution of resistance to HPPD-inhibiting herbicides in A. palmeri was documented in Kansas (KS) and later in Nebraska (NE). The objective of this study was to investigate the mechansim of HPPD-inhibitor (mesotrione) resistance in A. palmeri. Dose response analysis revealed that this population (KSR) was 10-18 times more resistant than their sensitive counterparts (MSS or KSS)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28419388/daytime-sleepiness-increases-with-age-in-early-adolescence-a-sleep-restriction-dose-response-study
#2
Ian G Campbell, Christopher S Burright, Amanda M Kraus, Kevin J Grimm, Irwin Feinberg
Study Objectives: Daytime sleepiness increases across adolescence. This increase is commonly attributed to insufficient sleep durations resulting from increasingly limited time in bed. We tested the effects of 3 sleep schedules on daytime sleepiness and whether these effects changed with age in early adolescence. Methods: In 77 children ranging in age from 9.9 to 14 years, objective (multiple sleep latency test - MSLT) and subjective (Karolinska sleepiness scale -KSS) sleepiness was measured following 4 consecutive nights of either 7, 8...
April 17, 2017: Sleep
https://www.readbyqxmd.com/read/28416171/the-comparison-of-knee-osteoarthritis-treatment-with-single-dose-bone-marrow-derived-mononuclear-cells-vs-hyaluronic-acid-injections
#3
Valdis Goncars, Eriks Jakobsons, Kristaps Blums, Ieva Briede, Liene Patetko, Kristaps Erglis, Martins Erglis, Konstantins Kalnberzs, Indrikis Muiznieks, Andrejs Erglis
OBJECTIVE: The aim of this study was to compare treatment methods of the knee joint degenerative osteoarthritis, using autologous bone marrow-derived mononuclear cells and hyaluronic acid injections and observe prevalence of adverse effects in both groups. MATERIALS AND METHODS: A prospective randomized controlled clinical trial was carried out. The analysis of pain and changes in osteoarthritis symptoms after a single intra-articular bone marrow-derived mononuclear cell injection into the knee joint in the Kellgren-Lawrence stage II-III osteoarthritis during the 12-month period were performed...
March 22, 2017: Medicina
https://www.readbyqxmd.com/read/28390882/risk-benefit-on-quality-of-life-after-total-knee-arthroplasty-in-octogenarians
#4
Alejandro Lizaur-Utrilla, Daniel Martinez-Mendez, Francisco A Miralles-Muñoz, Luis Marco-Gomez, Fernando A Lopez-Prats
BACKGROUND: Clinical outcomes of total knee arthroplasty (TKA) in very older patients have been widely studied, but the available evidence on quality of life (QOL) is limited. The objective was to evaluate the impact of TKA on the QOL in octogenarian patients and assess whether the risk-benefit justified surgery. METHODS: Prospective study comparing 143 octogenarian and 149 septuagenarian patients. QOL was assessed with the Short Form-12 (SF-12) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaires and functional outcomes with the Knee Society score (KSS)...
March 16, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28389879/superior-long-term-survival-for-fixed-bearing-compared-with-mobile-bearing-in-ligament-balanced-total-knee-arthroplasty
#5
P J C Heesterbeek, A H van Houten, J S Klenk, H Eijer, B Christen, A B Wymenga, A J Schuster
PURPOSE: Only few long-term data on ligament-balanced cruciate-retaining total knee arthroplasty (CR TKA) are currently available. Either a mobile- or fixed-bearing insert can be chosen, which showed good mid-term outcome and few complications and revisions. This multi-centre retrospective cross-sectional cohort study investigated the 12-year results of primary TKA using a balancing gap technique and compared survival and clinical outcome between fixed and mobile inserts. METHODS: In this retrospective cross-sectional cohort study, 557 cases of three clinics (2 Swiss, 1 Dutch) operated between 1998 and 2003 with the first series of a TKA implanted with a balanced gap technique (433 (77...
April 7, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28378275/what-is-the-responsiveness-and-respondent-burden-of-the-new-knee-society-score
#6
Rajesh N Maniar, Parul R Maniar, Debashish Chanda, Dnyaneshwar Gajbhare, Toral Chouhan
BACKGROUND: Although the new Knee Society score (NKSS) has been validated by a task force, a longitudinal study of the same cohort of patients to evaluate the score's responsiveness and respondent burden has not been reported, to our knowledge. QUESTIONS/PURPOSES: We analyzed the NKSS for (1) responsiveness; (2) respondent burden; and (3) convergent validity in 148 patients studied longitudinally during more than 1 year. METHODS: During an 8-month period, 165 patients underwent TKA by the same surgeon at our institution, of whom 148 (90%) completed this study; the others were excluded because of distance to travel or loss to followup at the specified time...
April 4, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28366049/does-obesity-influence-early-outcome-of-fixed-bearing-unicompartmental-knee-arthroplasty
#7
Yew Lok Woo, Yong Qiang Jerry Chen, Mun Chun Lai, Kheng Jin Darren Tay, Shi-Lu Chia, Ngai Nung Lo, Seng Jin Yeo
Obesity is a known major contributing risk factor for knee osteoarthritis (OA). It is also believed that obese unicompartmental knee arthroplasty (UKA) patients tend to have poorer outcome and possible early failure. The purpose of this study is to investigate the early outcome of obese UKA patients in a single institution. Patients who underwent fixed bearing medial UKA in between year 2005 and 2010 were included in this study. They were divided into four groups based on Body Mass Index (BMI): 25 kg/m(2) (Control); 25-29...
January 1, 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28360505/intra-articular-hyaluronic-acid-is-superior-to-steroids-in-knee-osteoarthritis-a-comparative-randomized-study
#8
Raju Vaishya, Ramsagar Pandit, Amit Kumar Agarwal, Vipul Vijay
BACKGROUND: To compare the short and mid-term results of intraarticular triamcinolone hexacetonide and hyaluronic acid (HA) in knee osteoarthritis. METHODS: A prospective randomized study including 40 patients in steroid and 42 patients in HA group. The outcome was evaluated with Knee Society Score (KSS) and Visual Analog Scale (VAS). RESULT: On KSS function and VAS score, there was no difference till four weeks. On KSS pain there was no difference till 12 weeks (P > 0...
January 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28321477/total-knee-arthroplasty-after-varus-distal-femoral-osteotomy-vs-native-knee-similar-results-in-a-case-control-study
#9
Romain Gaillard, Timothy Lording, Sebastien Lustig, Elvire Servien, Philippe Neyret
PURPOSE: The aim of this study was to investigate the results of total knee arthroplasty (TKA) performed after varus distal femoral osteotomy (VrDFO), in comparison to a control group of TKAs performed as the primary intervention for arthrosis. Main hypothesis was that the medium term results for the two groups would be similar. METHODS: All TKAs performed after VrDFO were extracted from a single centre, prospective database of 4046 arthroplasties. A case-control study was performed with a control group comprising two TKAs performed as the primary intervention for each TKA after VrDFO, and matched for sex, age at intervention, body mass index, the type of arthrosis and the type of implant...
March 20, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28318305/on-demand-driver-vigilance-enhancement-without-explicit-drowsiness-detection-further-analysis-of-the-pilot-study-results
#10
R Michael Van Auken, Brad K Hagoski, Dean P Chiang, Shane Chang
OBJECTIVE: A new active safety concept that engages the driver's psychosensory pain-processing mechanism to automatically trigger vigilance enhancement on-demand was proposed in Chang ( 2012 ). This concept is based on the hypothesis that a human's pain threshold will decline as he/she becomes drowsy, consequently triggering the vigilance enhancer. The objective of this pilot study was to develop methods to test this hypothesis, the results of which could lead to further refinement of the hypothesis and methods, with the ultimate goal of developing new active safety concepts that exploit the driver's endogenous psychosensory pain-processing mechanisms...
March 20, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28302132/long-term-results-and-comparison-of-the-three-different-high-tibial-osteotomy-and-fixation-techniques-in-medial-compartment-arthrosis
#11
Gökhan Polat, Halil İbrahim Balcı, Mehmet Fevzi Çakmak, Mehmet Demirel, Cengiz Şen, Mehmet Aşık
BACKGROUND: The purpose of this study is to report and analyze the long-term outcomes of the patients who underwent high tibial osteotomy (HTO) with three different techniques for the treatment of medial compartment arthrosis. METHODS: A total of 187 patients (195 knees) who underwent HTO between 1990 and 2010 were retrospectively evaluated. Eighty-eight knees, opening-wedge osteotomy with Puddu plate (group A); 51 knees, transverse osteotomy below the tubercle with external fixator (group B); and 29 knees, closing-wedge osteotomy with staple fixation (group C) were included in the study...
March 16, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28300964/effects-of-a-12-hour-shift-on-mood-states-and-sleepiness-of-neonatal-intensive-care-unit-nurses
#12
Tadeu Sartini Ferreira, Clarice Zinato Moreira, James Guo, Franco Noce
OBJECTIVE: To assess the effect of a 12-hour shift on mood states and sleepiness at the beginning and end of the shift. METHOD: Quantitative, cross-sectional and descriptive study.It was conducted with 70 neonatal intensive care unit nurses. The Brunel Mood Scale (BRUMS), Karolinska Sleepiness Scale (KSS), and a socio-demographic profile questionnaire were administered. RESULTS: When the KSS and BRUMS scores were compared at the beginning of the shift associations were found with previous sleep quality (p ≤ 0...
March 9, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28293867/binding-specificity-of-r-10g-and-tra-1-60-81-and-substrate-specificity-of-keratanase-ii-studied-with-chemically-synthesized-oligosaccharides
#13
Hiromi Nakao, Yuko Nagai, Aya Kojima, Hidenao Toyoda, Nobuko Kawasaki, Toshisuke Kawasaki
Recently, we established a mouse monoclonal antibody specific to hiPS/ hES cells, R-10G, which recognizes a type of keratan sulfate. Keratan sulfates (KS) comprise a family of glycosaminoglycans consisting of the repeating unit of [Gal-GlcNAc(6S)]. However, there is a diversity in the degree of sulfation at Gal and GlcNAc residues, and also in the mode of linkage, Galβ1 - 3GlcNAc (type 1) or Galβ1 - 4GlcNAc (type 2). To gain more insight into the binding specificity of R-10G, we carried out an ELISA test on avidin-coated plates using polyethylene glycol (PEG)3-biotinylated derivatives of a series of N-acetyllactosamine tetrasaccharides (keratan sulfates (KSs))...
March 14, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28261432/comparison-of-clinical-and-radiological-results-according-to-glenosphere-position-in-reverse-total-shoulder-arthroplasty-a-short-term-follow-up-study
#14
Chang Hyuk Choi, Sung Guk Kim, Jae Jun Lee, Byung Hoon Kwack
BACKGROUND: In a previous biomechanical study, eccentric glenospheres with more inferior position of the center of rotation were shown to improve range of motion and reduce the incidence of scapular notching after reverse total shoulder arthroplasty (RSA). The purpose of this study was to compare the clinical and radiological results of RSA using an eccentric glenosphere to those using a concentric glenosphere and to determine the usefulness of the eccentric glenosphere. METHODS: From 2009 to 2015, we performed a retrospective review of 20 consecutive patients who underwent RSA using a deltopectoral approach...
March 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28253923/patient-reported-health-outcomes-after-total-hip-and-knee-surgery-in-a-dutch-university-hospital-setting-results-of-twenty-years-clinical-registry
#15
Philip J van der Wees, Joost J G Wammes, Reinier P Akkermans, Jan Koetsenruijter, Gert P Westert, Albert van Kampen, Gerjon Hannink, Maarten de Waal-Malefijt, B Willem Schreurs
BACKGROUND: Patient-Reported Outcome (PRO) measurement is a method for measuring perceptions of patients on their health and quality of life. The aim of this paper is to present the results of PRO measurements in total hip and knee replacement as routinely collected during 20 years of surgery in a university hospital setting. METHODS: Data of consecutive patients between 1993 and 2014 were collected. Health outcomes were measured pre-surgery and at 3, 6, and 12 months post-surgery...
March 3, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28241088/clinical-outcome-of-total-knee-arthroplasty-after-prior-microfracture-a-matched-cohort-study
#16
Mohammad Humza Ansari, Ayoosh Pareek, Nick R Johnson, Matthew P Abdel, Michael J Stuart, Aaron J Krych
Microfracture (MFX) is a common operation for articular cartilage lesions. Data for patients who underwent total knee arthroplasty (TKA) after previous MFX are limited. The purpose of this study was to determine the outcomes, complications, and factors that influence outcomes in patients with previous MFX compared with those without previous MFX. Between 2005 and 2014, twenty-one TKAs were performed at a single tertiary care academic institution in patients with prior history of MFX surgery. These patients were retrospectively reviewed and matched 2:1 to patients who did not undergo previous MFX (n=42)...
February 27, 2017: Orthopedics
https://www.readbyqxmd.com/read/28237217/outcomes-of-newer-generation-cementless-total-knee-arthroplasty-beaded-periapatite-coated-vs-highly-porous-titanium-coated-implants
#17
Steven F Harwin, Nirav K Patel, Morad Chughtai, Anton Khlopas, Prem N Ramkumar, Martin Roche, Michael A Mont
BACKGROUND: Newer generation cementless total knee arthroplasty (TKA) designs are available and have novel implant coatings. We evaluated and compared beaded periapatite (PA)-coated vs highly porous titanium-coated cementless TKAs. Specifically, we compared: (1) survivorship, (2) Knee Society Scores (KSSs) and range of motion, (3) complications, and (4) radiographic findings. METHODS: There were 805 TKAs with beaded PA-coated tibial and patellar components (PA group; mean age 67 years; range 41-86 years), and 219 TKAs with highly porous titanium-coated tibial and patella components (mean age 66 years; range 34-88 years)...
February 3, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28216747/complex-ao-type-c3-distal-femur-fractures-results-after-fixation-with-a-lateral-locked-plate-using-modified-swashbuckler-approach
#18
Anuj Agrawal, Vivek Kiyawat
BACKGROUND: Complex AO type C3 fractures of the distal femur are challenging injuries, fraught with complications such as malunion and stiffness. We prospectively evaluated a consecutive series of patients with complex AO type C3 distal femur fractures to determine the clinicoradiological outcome after fixation with a single locked plate using modified swashbuckler approach. MATERIALS AND METHODS: 12 patients with C3 type distal femur fractures treated with a lateral locked plate, using a modified swashbuckler approach, were included in the study...
January 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28196393/does-manipulation-under-anesthesia-increase-the-risk-of-revision-total-knee-arthroplasty-a-matched-case-control-study
#19
Todd P Pierce, Kimona Issa, Anthony Festa, Anthony J Scillia, Vincent K McInerney, Michael A Mont
Manipulation under anesthesia (MUA) can help patients regain an adequate range of motion (ROM) following total knee arthroplasty (TKA). Although there are studies reporting that MUA can assist in improving ROM, there is a paucity of studies regarding whether requiring an MUA is associated with an increased risk of revision. The purpose of this study was to assess the: (1) incidence of revision TKA and (2) outcomes of those undergoing MUA and compare it with a matched cohort who did not require MUA. A prospectively collected database of two high-volume institutions was assessed for patients who required a single MUA following TKA between 2005 and 2011...
February 14, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28188394/algorithmic-pie-crusting-of-the-medial-collateral-ligament-guided-by-sensing-technology-affects-the-use-of-constrained-inserts-during-total-knee-arthroplasty
#20
Spencer Amundsen, Yuo-Yu Lee, Alejandro González Della Valle
BACKGROUND: Intra-operative sensing technology is an alternative to standard techniques in total knee arthroplasty (TKA) for determining balance by providing quantitative analysis of loads and point of contact throughout a range of motion. We used intra-operative sensing (VERASENSE-OrthoSensor, Inc.) to examine pie-crusting release of the medial collateral ligament in knees with varus deformity (study group) in comparison to a control group where balance was obtained using a classic release technique and assessed using laminar spreaders, spacer blocks, manual stress, and a ruler...
February 10, 2017: International Orthopaedics
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