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JOURNAL ARTICLE
Stylianos Tzeis, Edward P Gerstenfeld, Jonathan Kalman, Eduardo B Saad, Alireza Sepehri Shamloo, Jason G Andrade, Chirag R Barbhaiya, Tina Baykaner, Serge Boveda, Hugh Calkins, Ngai-Yin Chan, Minglong Chen, Shih-Ann Chen, Nikolaos Dagres, Ralph J Damiano, Tom De Potter, Isabel Deisenhofer, Nicolas Derval, Luigi Di Biase, Mattias Duytschaever, Katia Dyrda, Gerhard Hindricks, Meleze Hocini, Young-Hoon Kim, Mark la Meir, Jose Luis Merino, Gregory F Michaud, Andrea Natale, Isabelle Nault, Santiago Nava, Takashi Nitta, Mark O'Neill, Hui-Nam Pak, Jonathan P Piccini, Helmut Pürerfellner, Tobias Reichlin, Luis Carlos Saenz, Prashanthan Sanders, Richard Schilling, Boris Schmidt, Gregory E Supple, Kevin L Thomas, Claudio Tondo, Atul Verma, Elaine Y Wan, Daniel Steven, Michael-Joseph Agbayani, T Jared Bunch, Aman Chugh, Juan Carlos Díaz, James V Freeman, Carina Abigail Hardy, Hein Heidbuchel, Sofian Johar, Dominik Linz, Bart Maesen, Peter A Noseworthy, Seil Oh, Andreu Porta-Sanchez, Tatjana Potpara, Gerardo Rodriguez-Diez, Frederic Sacher, Piotr Suwalski, Serge A Trines
In the last three decades, ablation of atrial fibrillation (AF) has become an evidence-based safe and efficacious treatment for managing the most common cardiac arrhythmia. In 2007, the first joint expert consensus document was issued, guiding healthcare professionals involved in catheter or surgical AF ablation. Mounting research evidence and technological advances have resulted in a rapidly changing landscape in the field of catheter and surgical AF ablation, thus stressing the need for regularly updated versions of this partnership which were issued in 2012 and 2017...
March 30, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#22
JOURNAL ARTICLE
C Barrett Bowling, Richard A Faldowski, Richard Sloane, Carl Pieper, Tyson H Brown, Erin E Dooley, Brett T Burrows, Norrina B Allen, Kelley Pettee Gabriel, Cora E Lewis
BACKGROUND: Multimorbidity research has focused on the prevalence and consequences of multimorbidity in older populations. Less is known about the accumulation of chronic conditions earlier in the life course. METHODS: We identified patterns of longitudinal multimorbidity accumulation using 30 years of data from in-person exams, annual follow-ups, and adjudicated end-points among 4,945 participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study...
2024: J Multimorb Comorb
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JOURNAL ARTICLE
Ebraham Alskaf, Richard Crawley, Cian M Scannell, Avan Suinesiaputra, Alistair Young, Pier-Giorgio Masci, Divaka Perera, Amedeo Chiribiri
BACKGROUND: Prediction of clinical outcomes in coronary artery disease (CAD) has been conventionally achieved using clinical risk factors. The relationship between imaging features and outcome is still not well understood. This study aims to use artificial intelligence to link image features with mortality outcome. METHODS: A retrospective study was performed on patients who had stress perfusion cardiac magnetic resonance (SP-CMR) between 2011 and 2021. The endpoint was all-cause mortality...
March 30, 2024: Journal of medical artificial intelligence
#24
JOURNAL ARTICLE
Richard E Ahl, Dorsa Amir, Katherine McAuliffe
Does a sense of having less or more than what one needs affect one's generosity? The question of how resource access influences prosocial behavior has received much attention in studies with adults but has produced conflicting findings. To better understand this relationship, we tested whether resource access affects generosity in the developing mind. In our preregistered investigation, we used a narrative recall method to explore how temporary, experimentally evoked states of resource abundance or scarcity affect children's sharing...
April 5, 2024: Journal of Experimental Child Psychology
#25
JOURNAL ARTICLE
Helena I M Boshoff, Katherine Young, Yong-Mo Ahn, Veena D Yadav, Brendan M Crowley, Lihu Yang, Jing Su, Sangmi Oh, Kriti Arora, Jenna Andrews, Michelle Manikkam, Michelle Sutphin, Anthony J Smith, Danielle M Weiner, Michaela K Piazza, Joel D Fleegle, Felipe Gomez, Emmannual K Dayao, Brendan Prideaux, Matthew Zimmerman, Firat Kaya, Jansy Sarathy, Vee Yang Tan, Laura E Via, Richard Tschirret-Guth, Anne J Lenaerts, Gregory T Robertson, Véronique Dartois, David B Olsen, Clifton E Barry
Linezolid is a drug with proven human antitubercular activity whose use is limited to highly drug-resistant patients because of its toxicity. This toxicity is related to its mechanism of action─linezolid inhibits protein synthesis in both bacteria and eukaryotic mitochondria. A highly selective and potent series of oxazolidinones, bearing a 5-aminomethyl moiety (in place of the typical 5-acetamidomethyl moiety of linezolid), was identified. Linezolid-resistant mutants were cross-resistant to these molecules but not vice versa...
April 6, 2024: ACS Infectious Diseases
#26
JOURNAL ARTICLE
Richard M Martin, Emma L Turner, Grace J Young, Chris Metcalfe, Eleanor I Walsh, J Athene Lane, Jonathan A C Sterne, Sian Noble, Peter Holding, Yoav Ben-Shlomo, Naomi J Williams, Nora Pashayan, Mai Ngoc Bui, Peter C Albertsen, Tyler M Seibert, Anthony L Zietman, Jon Oxley, Jan Adolfsson, Malcolm D Mason, George Davey Smith, David E Neal, Freddie C Hamdy, Jenny L Donovan
IMPORTANCE: The Cluster Randomized Trial of PSA Testing for Prostate Cancer (CAP) reported no effect of prostate-specific antigen (PSA) screening on prostate cancer mortality at a median 10-year follow-up (primary outcome), but the long-term effects of PSA screening on prostate cancer mortality remain unclear. OBJECTIVE: To evaluate the effect of a single invitation for PSA screening on prostate cancer-specific mortality at a median 15-year follow-up compared with no invitation for screening...
April 6, 2024: JAMA
#27
JOURNAL ARTICLE
Richard Nyeko, Nelson Okello, Christine Joy Abeja, Proscovia Adyanga, Betty Apio, Caroline Kambugu Nabasirye, Pamella Aol Mwa, Racheal Angom, Fadhil Geriga, Julie Buser
Purpose: Reproductive health (RH) is a critical issue among cancer survivors worldwide. However, in developing countries where RH services for patients with cancer are often lacking, reproductive concerns among adolescent and young adult (AYA) survivors remain uncertain. In this study, we assessed the reproductive concerns of AYA cancer survivors in a resource-limited context of Uganda. Methods: We collected data from AYA cancer survivors at two facilities in Uganda using an interviewer-administered questionnaire...
April 5, 2024: Journal of Adolescent and Young Adult Oncology
#28
JOURNAL ARTICLE
Lindsey J Patton, Angelica Morris, Amanda Nash, Kendel Richards, Leslie Huntington, Lori Batchelor, Jenna Harris, Virginia Young, Carol J Howe
BACKGROUND: Pediatric patients require central venous catheters to maintain adequate hydration, nutritional status, and delivery of life-saving medications in the pediatric intensive care unit. Although central venous catheters provide critical medical therapies, their use increases the risk of severe infection, morbidity, and mortality. Adopting an evidence-based central line-associated bloodstream infection (CLABSI) bundle to guide nursing practice can decrease and sustain low CLABSI rates, but reliable and consistent implementation is challenging...
2024: Pediatric Quality & Safety
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JOURNAL ARTICLE
Neetika Gupta, Elka Miller, Aashim Bhatia, Julie Richer, Richard I Aviv, Nagwa Wilson
Monogenic cerebral vasculopathy is a rare but progressively recognizable cause of pediatric cerebral vasculopathy manifesting as early as fetal life. These monogenic cerebral vasculopathies can be silent or manifest variably as fetal or neonatal distress, neurologic deficit, developmental delay, cerebral palsy, seizures, or stroke. The radiologic findings can be nonspecific, but the presence of disease-specific cerebral and extracerebral imaging features can point to a diagnosis and guide genetic testing, allowing targeted treatment...
May 2024: Radiographics: a Review Publication of the Radiological Society of North America, Inc
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JOURNAL ARTICLE
Ethel Quayle, Matthias Schwannauer, Filippo Varese, Kim Cartwright, Will Hewins, Cindy Chan, Alice Newton, Prathiba Chitsabesan, Cathy Richards, Sandra Bucci
INTRODUCTION: Online child sexual abuse (OCSA) affects considerable numbers of children globally and is associated with a variety of mental health problems. Existing practitioner studies suggest that young people are infrequently asked about online abuse and practitioners have a fragmented understanding of the problems experienced or how they might approach them. There are very few evidence-based interventions that guide clinical assessment or practice. Digital Health Interventions (DHIs) have the potential to be an effective option where children and young people's services are challenged, including accessibility and anonymity...
2024: Frontiers in digital health
#31
JOURNAL ARTICLE
Stephanie Ruth Young, Elizabeth McManus Dworak, Greg J Byrne, Callie Madison Jones, Julia Yoshino Benavente, Lihua Yao, Laura M Curtis, Maria Varela Diaz, Richard Gershon, Michael Wolf, Cindy Nowinski
INTRODUCTION: Annual cognitive screening in older adults is essential for early detection of cognitive impairment, yet primary care settings face time constraints that present barriers to routine screening. A remote cognitive screener completed on a patient's personal smartphone before a visit has the potential to save primary care clinics time, encourage broader screening practices and increase early detection of cognitive decline. MyCog Mobile is a promising new remote smartphone-based cognitive screening app for primary care settings...
April 2, 2024: BMJ Open
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JOURNAL ARTICLE
Amie J Eisfeld, Lindsey N Anderson, Shufang Fan, Kevin B Walters, Peter J Halfmann, Danielle Westhoff Smith, Larissa B Thackray, Qing Tan, Amy C Sims, Vineet D Menachery, Alexandra Schäfer, Timothy P Sheahan, Adam S Cockrell, Kelly G Stratton, Bobbie-Jo M Webb-Robertson, Jennifer E Kyle, Kristin E Burnum-Johnson, Young-Mo Kim, Carrie D Nicora, Zuleyma Peralta, Alhaji U N'jai, Foday Sahr, Harm van Bakel, Michael S Diamond, Ralph S Baric, Thomas O Metz, Richard D Smith, Yoshihiro Kawaoka, Katrina M Waters
Human infections caused by viral pathogens trigger a complex gamut of host responses that limit disease, resolve infection, generate immunity, and contribute to severe disease or death. Here, we present experimental methods and multi-omics data capture approaches representing the global host response to infection generated from 45 individual experiments involving human viruses from the Orthomyxoviridae, Filoviridae, Flaviviridae, and Coronaviridae families. Analogous experimental designs were implemented across human or mouse host model systems, longitudinal samples were collected over defined time courses, and global multi-omics data (transcriptomics, proteomics, metabolomics, and lipidomics) were acquired by microarray, RNA sequencing, or mass spectrometry analyses...
April 2, 2024: Scientific Data
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JOURNAL ARTICLE
Aneley Getahun Strobel, Prinika Prasad, Vinita Prasad, Ravi Naidu, Tracey Young-Sharma, Ana Suka, Matthew Richards, Donna Cameron, Courtney R Lane, Kirsty Buising, Benjamin P Howden, Sanjeshni Autar
OBJECTIVES: We analysed four years of laboratory data to characterise the species and determine the antimicrobial susceptibility profiles of enterococci as human pathogens in Fiji. The study also investigated the molecular epidemiology among the subset of vancomycin resistant enterococci (VRE). METHODS: This retrospective study reviewed bacteriological data from Colonial War Memorial Hospital (CWMH) and other healthcare facilities in the Central and Eastern divisions of Fiji...
March 31, 2024: Journal of Global Antimicrobial Resistance
#34
JOURNAL ARTICLE
Xenofon Baraliakos, Mikkel Østergaard, Denis Poddubnyy, Désirée van der Heijde, Atul Deodhar, Pedro M Machado, Victoria Navarro-Compán, Kay Geert A Hermann, Mitsumasa Kishimoto, Eun Young Lee, Lianne S Gensler, Uta Kiltz, Marco F Eigenmann, Patricia Pertel, Aimee Readie, Hanno B Richards, Brian Porter, Juergen Braun
INTRODUCTION: Spinal radiographic progression is an important outcome in radiographic axial spondyloarthritis (r-axSpA). SURPASS is the first head-to-head phase IIIb study comparing such changes in patients with r-axSpA treated with secukinumab (IL-17A inhibitor) versus adalimumab biosimilar (Sandoz adalimumab [SDZ-ADL]; TNF inhibitor). METHODS: Biologic-naïve patients with active r-axSpA, at high risk of radiographic progression (high-sensitivity C-reactive protein [hsCRP] ≥5 mg/L and/or ≥1 syndesmophyte[s] on spinal radiographs) were randomized (1:1:1) to secukinumab (150/300 mg) or SDZ-ADL (40 mg)...
March 31, 2024: Arthritis & Rheumatology
#35
REVIEW
Freya Luling Feilding, Laura Crosby, Emily Earle, Richard Beesley, Kerry Leslie, Eilean MacDonald, Catherine Wright, Debbie Wilson, Anna Sherriffs, Teresa Duerr, Athimalaipet V Ramanan
In juvenile idiopathic arthritis we have seen remarkable progress in the number of available licensed biological and small molecule treatments in the past two decades, leading to improved outcomes for patients. Designing clinical trials for these therapeutics is fraught with ethical, legislative, and practical challenges. However, many aspects of current clinical trial design in juvenile idiopathic arthritis do not meet the needs of patients and clinicians. Commonly used withdrawal trial designs raise substantial ethical concerns for patients and families who believe that they do not enable evidence-based and patient-centred decisions around medication choices...
March 26, 2024: Lancet Rheumatology
#36
JOURNAL ARTICLE
Ethel Quayle, Amanda Larkin, Matthias Schwannauer, Filippo Varese, Kim Cartwright, Prathiba Chitsabesan, Victoria Green, Gillian Radford, Cathy Richards, Sara Shafi, Pauline Whelan, Cindy Chan, William Hewins, Alice Newton, Erica Niebauer, Marina Sandys, Jennifer Ward, Sandra Bucci
BACKGROUND: There is growing evidence that Technology Assisted Sexual Abuse (TASA) represents a serious problem for large numbers of children. To date, there are very few evidence-based interventions available to young people (YP) after they have been exposed to this form of abuse, and access to support services remains a challenge. Digital tools such as smartphones have the potential to increase access to mental health support and may provide an opportunity for YP to both manage their distress and reduce the possibility of further victimization...
March 28, 2024: BMC Psychiatry
#37
JOURNAL ARTICLE
Richard Bränström, Mark L Hatzenbuehler, Micah R Lattanner, Nathan L Hollinsaid, Thomas W McDade, John E Pachankis
Sexual minority individuals have a markedly elevated risk of depression compared to heterosexuals. We examined early threats to social safety and chronically elevated inflammation as mechanisms contributing to this disparity in depression symptoms, and compared the relative strength of the co-occurrence between chronic inflammation and depression symptoms for sexual minorities versus heterosexuals. To do so, we analyzed data from a prospective cohort of sexual minority and heterosexual young adults (n = 595), recruited from a nationally representative sample, that included assessments of early threats to social safety in the form of adverse childhood interpersonal events, three biomarkers of inflammation (i...
March 26, 2024: Brain, Behavior, and Immunity
#38
JOURNAL ARTICLE
Melanie E Bennett, Deborah Medoff, Tovah Cowan, Lijuan Fang, Corinne Kacmarek, Maria Theodora Oikonomou, Monica E Calkins, Krista K Baker, Donna Bencivengo, Yasmine Boumaiz, Robert W Buchanan, Phillip Campbell, K N Roy Chengappa, Catherine G Conroy, Akinyi Cooke, Fanghong Dong, Mandy Fauble, Richard W Goldberg, Alexander Harvin, Megan B E Jumper, Belinda Kauffman, Christian Kelly, Christian G Kohler, Julie Kreyenbuhl, Lan Li, Alicia Lucksted, Russell L Margolis, Jill A Marsteller, Alex Moxam, Denise Namowicz, Jamie Oko, Jessie Riggs, Arunadevi Saravana, Deepak K Sarpal, Rachel Scheinberg, William R Smith, Richard States, Jerome Taylor, Crystal Vatza, Max Wolcott, Faith Dickerson
Tobacco smoking is highly prevalent in persons with psychosis and is the leading cause of preventable mortality in this population. Less is known about tobacco smoking in persons with first episode psychosis (FEP) and there have been no estimates about the prevalence of nicotine vaping in FEP. This study reports rates of tobacco smoking and nicotine vaping in young people with FEP enrolled in Coordinated Specialty Care programs in Pennsylvania and Maryland. Using data collected from 2021 to 2023, we examined lifetime and recent smoking and vaping and compared smokers and vapers to nonusers on symptoms, functioning, and substance use...
March 27, 2024: Schizophrenia Research
#39
JOURNAL ARTICLE
Genome and RNA sequencing boost neuromuscular diagnoses to 62% from 34% with exome sequencing alone.
Rhett G Marchant, Samantha J Bryen, Melanie Bahlo, Anita Cairns, Katherine R Chao, Alastair Corbett, Mark R Davis, Vijay S Ganesh, Roula Ghaoui, Kristi J Jones, Andrew J Kornberg, Monkol Lek, Christina Liang, Daniel G MacArthur, Emily C Oates, Anne O'Donnell-Luria, Gina L O'Grady, Ikeoluwa A Osei-Owusu, Haloom Rafehi, Stephen W Reddel, Richard H Roxburgh, Monique M Ryan, Sarah A Sandaradura, Liam W Scott, Elise Valkanas, Ben Weisburd, Helen Young, Frances J Evesson, Leigh B Waddell, Sandra T Cooper
OBJECTIVE: Most families with heritable neuromuscular disorders do not receive a molecular diagnosis. Here we evaluate diagnostic utility of exome, genome, RNA sequencing, and protein studies and provide evidence-based recommendations for their integration into practice. METHODS: In total, 247 families with suspected monogenic neuromuscular disorders who remained without a genetic diagnosis after standard diagnostic investigations underwent research-led massively parallel sequencing: neuromuscular disorder gene panel, exome, genome, and/or RNA sequencing to identify causal variants...
March 27, 2024: Annals of Clinical and Translational Neurology
#40
JOURNAL ARTICLE
Adeel Shah, Elissa Meites, John Lin, James P Hughes, Pamina M Gorbach, Brian Mustanski, Richard A Crosby, Elizabeth R Unger, Troy Querec, Matthew Golden, Lauri E Markowitz, Rachel L Winer
BACKGROUND: Among men who have sex with men (MSM) and transgender women (TGW), the dynamics of human papillomavirus (HPV) infections at different anatomical sites are not well understood. Information on HPV concordance between anatomic sites can inform the extent of autoinoculation, and susceptibility of different anatomic areas to HPV infection. We described and assessed correlates of HPV concordance across anal, oral, and genital samples. METHODS: We enrolled 1876 MSM and TGW aged 18 to 26 years in 3 US cities...
April 1, 2024: Sexually Transmitted Diseases
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