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https://www.readbyqxmd.com/read/29676392/integrated-genomic-analyses-of-de-novo-pathways-underlying-atypical-meningiomas
#1
Akdes Serin Harmancı, Mark W Youngblood, Victoria E Clark, Süleyman Coşkun, Octavian Henegariu, Daniel Duran, E Zeynep Erson-Omay, Leon D Kaulen, Tong Ihn Lee, Brian J Abraham, Matthias Simon, Boris Krischek, Marco Timmer, Roland Goldbrunner, S Bülent Omay, Jacob Baranoski, Burçin Baran, Geneive Carrión-Grant, Hanwen Bai, Ketu Mishra-Gorur, Johannes Schramm, Jennifer Moliterno, Alexander O Vortmeyer, Kaya Bilgüvar, Katsuhito Yasuno, Richard A Young, Murat Günel
This corrects the article DOI: 10.1038/ncomms14433.
April 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29675705/marked-increase-in-measles-vaccination-coverage-among-young-adults-in-switzerland-a-campaign-or-cohort-effect
#2
Ekkehardt Altpeter, Monica N Wymann, Jean-Luc Richard, Mirjam Mäusezahl-Feuz
OBJECTIVES: To evaluate the impact of the Swiss measles elimination strategy-including a mass media campaign-on vaccination coverage and awareness among young adults aged 20-29 years. METHODS: Comparison of the results of two cross-sectional population surveys in 2012 and 2015. RESULTS: Documented vaccination coverage increased from 77 to 88% for two doses of measles vaccine. Major determinants of complete vaccination were survey year, birth cohort, sex and the absence of prior measles disease...
April 19, 2018: International Journal of Public Health
https://www.readbyqxmd.com/read/29670548/neural-correlates-of-semantic-inhibition-in-relation-to-hypomanic-traits-an-fmri-study
#3
Delphine Raucher-Chéné, Sarah Terrien, Fabien Gierski, Alexandre Obert, Stéphanie Caillies, Chrystel Besche-Richard, Arthur Kaladjian
Objectives: Language modifications are a core feature of mania, but little is known about the semantic mechanisms behind these disturbances. The aim of the present study was thus to identify deficits in semantic inhibition and their respective neural activation patterns in a sample of individuals assessed for hypomanic personality traits. Methods: Thirty-six young adults with no neurological or psychiatric diagnoses were assessed for hypomanic personality traits with the Hypomanic Personality Scale (HPS) and underwent an fMRI task of semantic ambiguity resolution...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29670022/whole-genome-classification-and-phylogenetic-analyses-of-rotavirus-b-strains-from-the-united-states
#4
Frances K Shepherd, Diana Maria Herrera-Ibata, Elizabeth Porter, Nitipong Homwong, Richard Hesse, Jianfa Bai, Douglas G Marthaler
Rotaviruses (RVs) are a major etiological agent of acute viral gastroenteritis in humans and young animals, with rotavirus B (RVB) often detected in suckling and weaned pigs. Group A rotavirus classification is currently based on the two outer capsid proteins, VP7 and VP4, and the middle layer protein, VP6. Using RVB strains generated in this study and reference sequences from GenBank, pairwise identity frequency graphs and phylogenetic trees were constructed for the eleven gene segments of RVB to estimate the nucleotide identity cutoff values for different genotypes and determine the genotype diversity per gene segment...
April 18, 2018: Pathogens
https://www.readbyqxmd.com/read/29667722/acute-myelogenous-leukemia-in-adolescents-and-young-adults
#5
REVIEW
Ursula Creutzig, Matthew A Kutny, Ronald Barr, Richard F Schlenk, Raul C Ribeiro
The incidence of acute myelogenous leukemia (AML) increases progressively with age. Favorable genetic mutations are most prevalent in children, and unfavorable profiles increase proportionately in adolescents and young adults (AYA) and into later adulthood. Survival rates of AYA have improved over recent decades to 50-60%, but their accrual to clinical trials remains poor. In contrast to AYA with acute lymphoblastic leukemia, the prognostic benefit for AYA with AML enrolled in pediatric compared with adult trials is minor and only seen when different protocols are used...
April 18, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29666304/strategic-therapeutic-targeting-to-overcome-venetoclax-resistance-in-aggressive-b-cell-lymphomas
#6
Lan V Pham, Shengjian Huang, Hui Zhang, Jun Zhang, Taylor Bell, Shouhao Zhou, Elizabeth Pogue, Zhiyong Ding, Laura Lam, Jason R Westin, R Eric Davis, Ken H Young, L Jeffrey Medeiros, Richard J Ford, Krystle Nomie, Liang Zhang, Michael Wang
PURPOSE: B-cell lymphoma-2 (BCL-2), an anti-apoptotic protein often dysregulated in B-cell lymphomas, promotes cell survival and provides protection from stress. A recent Phase I first-in-human study of the BCL-2 inhibitor venetoclax in non-Hodgkin lymphoma showed an overall response rate of 44%. These promising clinical results prompted our examination of the biological effects and mechanism of action underlying venetoclax activity in aggressive B-cell lymphoma, including mantle cell lymphoma (MCL) and diffuse large B cell lymphoma (DLBCL)...
April 17, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29666158/qc-art-a-tool-for-real-time-quality-control-assessment-of-mass-spectrometry-based-proteomics-data
#7
Bryan A Stanfill, Ernesto S Nakayasu, Lisa M Bramer, Allison M Thompson, Charles K Ansong, Therese Clauss, Marina A Gritsenko, Matthew E Monroe, Ronald J Moore, Daniel J Orton, Paul D Piehowski, Athena A Schepmoes, Richard D Smith, Bobbie-Jo Webb-Robertson, Thomas O Metz, The Environmental Determinants Of Diabetes In The Young Teddy Study Group
Liquid chromatography-mass spectrometry (LC-MS)-based proteomics studies of large sample cohorts can easily require from months to years to complete. Acquiring consistent, high-quality data in such large-scale studies is challenging because of normal variations in instrumentation performance over time, as well as artifacts introduced by the samples themselves, such as those due to collection, storage and processing. Existing quality control methods for proteomics data primarily focus on post-hoc analysis to remove low-quality data that would degrade downstream statistics; they are not designed to evaluate the data in near real-time, which would allow for interventions as soon as deviations in data quality are detected...
April 17, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29665447/propensity-score-to-evaluate-prognosis-in-pregnancy-associated-breast-cancer-analysis-from-a-french-cancer-network
#8
Anne-Sophie Boudy, Iptissem Naoura, Lise Selleret, Sonia Zilberman, Joseph Gligorov, Sandrine Richard, Isabelle Thomassin-Naggara, Nathalie Chabbert-Buffet, Marcos Ballester, Sofiane Bendifallah, Emile Darai
PURPOSE: To compare the prognosis of pregnancy associated breast cancer occurring during pregnancy (BCP) to non-pregnancy associated breast cancers (non-BCP) in young women managed at a national expert center. METHODS: Retrospective cohort study of a prospective database using propensity score matching (PSM) analysis with known prognostic factors. RESULTS: We analyzed data of 49 patients with BCP and 104 with non-BCP diagnosed between 2002 and 2017 at Tenon University Hospital (Paris, France)...
April 14, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29662767/reconstruction-of-the-lateral-tibia-plateau-fracture-with-a-third-triangular-support-screw-a-biomechanical-study
#9
Eduardo Moran, Ivan Zderic, Kajetan Klos, Paul Simons, Miguel Triana, R Geoff Richards, Boyko Gueorguiev, Mark Lenz
Background: Split fractures of the lateral tibia plateau in young patients with good bone quality are commonly treated using two minimally invasive percutaneous lag screws, followed by unloading of the knee joint. Improved stability could be achieved with the use of a third screw inserted either in the jail-technique fashion or with a triangular support screw configuration. The aim of this study was to investigate under cyclic loading the compliance and endurance of the triangular support fixation in comparison with the standard two lag-screw fixation and the jail technique...
October 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29661555/directly-quantified-dietary-n-3-fatty-acid-intakes-of-canadian-toddlers-are-lower-than-current-dietary-recommendations
#10
R J Scott Lacombe, Richard J Kratz, Bruce J Holub
To date, few studies have evaluated the intake of dietary n-3 polyunsaturated fatty acids (PUFA) in young North American children and current estimates are based on indirect approaches which have concerning limitations. Furthermore, there is a lack of available knowledge regarding the proportion of children meeting current dietary recommendations for the consumption of long-chain n-3 PUFA as α-linolenic acid (ALA) and eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA). The objective of the present study was to directly quantify the intake of n-3 PUFA in toddlers aged 2 to 3 years and determine if intakes met international recommendations...
March 2, 2018: Nutrition Research
https://www.readbyqxmd.com/read/29656554/a-single-day-of-bed-rest-irrespective-of-energy-balance-does-not-affect-skeletal-muscle-gene-expression-or-insulin-sensitivity
#11
Marlou L Dirks, Francis B Stephens, Sarah R Jackman, Jesús Galera Gordo, David Machin, Richard M Pulsford, Luc Jc van Loon, Benjamin T Wall
NEW FINDINGS: What is the central question of this study? What are the initial metabolic and molecular events that underpin bed rest-induced skeletal muscle deconditioning, and what is the contribution of energy balance? What is the main finding and its importance? A single day of bed rest, irrespective of energy balance, did not lead to overt changes in skeletal muscle gene expression or insulin sensitivity. More than one day of physical inactivity is required to observe the insulin resistance and robust skeletal muscle transcriptional responses associated with bed rest and consequent alterations in energy balance...
April 15, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29649711/the-interaction-of-bdnf-val66met-ptsd-and-child-abuse-on-psychophysiological-reactivity-and-hpa-axis-function-in-a-sample-of-gulf-war-veterans
#12
Dmitri A Young, Thomas C Neylan, Aoife O'Donovan, Thomas Metzler, Anne Richards, Jessica A Ross, Sabra S Inslicht
INTRODUCTION: While the BDNF Val66Met polymorphism has been linked to various psychological disorders, limited focus has been on its relationship to posttraumatic stress disorder (PTSD) and early traumas such as child abuse. Therefore, we assessed whether Val66Met was associated with fear potentiated psychophysiological response and HPA axis dysfunction and whether PTSD status or child abuse history moderated these outcomes in a sample of Veterans. METHODS: 226 and 173 participants engaged in a fear potentiated acoustic startle paradigm and a dexamethasone suppression test (DST) respectively...
April 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29645056/electrochemical-hg-2-detection-at-tannic-acid-gold-nanoparticle-modified-electrodes-by-square-wave-voltammetry
#13
Alex L Suherman, Sabine Kuss, Eden E L Tanner, Neil P Young, Richard G Compton
We report the electrochemical sensing of Hg2+ based on tannic acid capped gold nanoparticle (AuNP@TA) complexes. At optimal conditions using square wave voltammetry, the presented analytical method exhibits a "measurable lower limit" of 100.0 fM. This limit is considerably below the permissible level of 30.0 nM for inorganic mercury in drinking water, specified by the World Health Organization (WHO). The effect of potentially interfering ions, such as Zn2+ and Al3+, was studied and results indicate an excellent selectivity for Hg2+...
April 12, 2018: Analyst
https://www.readbyqxmd.com/read/29644471/assessment-of-psychological-distress-among-asian-adolescents-and-young-adults-aya-cancer-patients-using-the-distress-thermometer-a-prospective-longitudinal-study
#14
Alexandre Chan, Eileen Poon, Wei Lin Goh, Yanxiang Gan, Chia Jie Tan, Kelvin Yeo, Annabelle Chua, Magdalene Chee, Yi Chye Law, Nagavalli Somasundaram, Ravindran Kanesvaran, Quan Sing Ng, Chee Kian Tham, Chee Keong Toh, Soon Thye Lim, Miriam Tao, Tiffany Tang, Richard Quek, Mohamad Farid
PURPOSE: Since few studies have investigated whether the Distress Thermometer (DT) in Asian adolescent and young adult (AYA) cancer patients (between 15 and 39 years), we investigated the appropriateness of the DT as a screening tool for psychological symptom burden in these AYA patients and to evaluate AYA patients' distress across a trajectory of three time points longitudinally over a 6-month period. METHODS: This was a prospective, longitudinal study. Recruited Asian AYA patients were diagnosed with lymphomas, sarcomas, primary brain malignancies, or germ cell tumors...
April 11, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29629651/designing-a-brief-behaviour-change-intervention-to-reduce-sexually-transmitted-infections-a-discrete-choice-experiment
#15
Alec Miners, Carrie Llewellyn, Carina King, Alex Pollard, Anupama Roy, Richard Gilson, Alison Rodger, Fiona Burns, Maryam Shahmanesh
To understand whether people attending sexual health (SH) clinics are willing to participate in a brief behavioural change intervention (BBCI) to reduce the likelihood of future sexually transmitted infections (STIs) and to understand their preferences for different service designs, we conducted a discrete choice experiment (DCE) with young heterosexual adults (aged 16-25 years), and men who have sex with men (MSM) aged 16 or above, attending SH clinics in England. Data from 368 participants showed that people particularly valued BBCIs that involved talking (OR 1...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29628217/development-and-characterization-of-a-point-of-care-rate-based-transcutaneous-respiratory-status-monitor
#16
Xudong Ge, Prosper Adangwa, Ja Young Lim, Yordan Kostov, Leah Tolosa, Richard Pierson, Daniel Herr, Govind Rao
Blood gas measurements provide vital clinical information in critical care. The current "gold standard" for blood gas measurements involves obtaining blood samples, which can be painful and can lead to bleeding, thrombus formation, or infection. Mass transfer equilibrium-based transcutaneous blood gas monitors have been used since the 1970s, but they require heating the skin to ≥42 °C to speed up the transcutaneous gas diffusion. Thus, these devices have a potential risk for skin burns. Here we report a new generation of noninvasive device for respiratory status assessment...
April 5, 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29625954/youth-mental-health-services-utilization-rates-after-a-large-scale-social-media-campaign-population-based-interrupted-time-series-analysis
#17
Richard G Booth, Britney N Allen, Krista M Bray Jenkyn, Lihua Li, Salimah Z Shariff
BACKGROUND: Despite the uptake of mass media campaigns, their overall impact remains unclear. Since 2011, a Canadian telecommunications company has operated an annual, large-scale mental health advocacy campaign (Bell Let's Talk) focused on mental health awareness and stigma reduction. In February 2012, the campaign began to explicitly leverage the social media platform Twitter and incented participation from the public by promising donations of Can $0.05 for each interaction with a campaign-specific username (@Bell_LetsTalk)...
April 6, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29624559/risk-factors-for-oral-hpv-infection-among-young-men-who-have-sex-with-men-2-cities-united-states-2012-2014
#18
Sara E Oliver, Pamina Gorbach, Beau Gratzer, Martin Steinau, Tom Collins, Adam Parrish, Peter R Kerndt, Richard Crosby, Elizabeth R Unger, Lauri E Markowitz, Elissa Meites
BACKGROUND: Men who have sex with men (MSM) are at risk for cancers attributable to human papillomavirus (HPV), including oropharyngeal cancer. HPV vaccination is recommended for U.S. MSM through age 26 years. Oral HPV infection is associated with oropharyngeal cancer. We determined oral HPV prevalence and risk factors among young MSM. METHODS: The Young Men's HPV study enrolled MSM aged 18-26 years from clinics in Chicago and Los Angeles during 2012-2014. Participants self-reported demographics, sexual behaviors, vaccination and HIV status...
April 5, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29624441/motives-and-concerns-associated-with-geosocial-networking-app-usage-an-exploratory-study-among-heterosexual-college-students-in-the-united-states
#19
Meredith Griffin, Amy Canevello, Richard D McAnulty
Geosocial network application (GSNA) use is common among young adults. However, there is little empirical research into patterns of use, motives, and potential concerns among app users. A total of 409 heterosexual students from a public university in the southeast United States participated in an online survey. Sample composition was primarily Caucasian and in their first 2 years of college. Average age was 19.7 years. Results revealed that 39 percent of participants had used a GSN app, and 60 percent of these were regular users...
April 2018: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/29621994/the-pigeon-project-protocol-for-a-longitudinal-study-examining-psychosocial-behavioural-and-ethical-issues-and-outcomes-in-cancer-tumour-genomic-profiling
#20
Megan Best, Ainsley J Newson, Bettina Meiser, Ilona Juraskova, David Goldstein, Kathy Tucker, Mandy L Ballinger, Dominique Hess, Timothy E Schlub, Barbara Biesecker, Richard Vines, Kate Vines, David Thomas, Mary-Anne Young, Jacqueline Savard, Chris Jacobs, Phyllis Butow
BACKGROUND: Genomic sequencing in cancer (both tumour and germline), and development of therapies targeted to tumour genetic status, hold great promise for improvement of patient outcomes. However, the imminent introduction of genomics into clinical practice calls for better understanding of how patients value, experience, and cope with this novel technology and its often complex results. Here we describe a protocol for a novel mixed-methods, prospective study (PiGeOn) that aims to examine patients' psychosocial, cognitive, affective and behavioural responses to tumour genomic profiling and to integrate a parallel critical ethical analysis of returning results...
April 5, 2018: BMC Cancer
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