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JOURNAL ARTICLE
Emily C Pritchard, Bianca Haase, Meredith J Wall, Carolyn R O'Brien, Richard Gowan, Kim Mizzi, Annie Kicinski, Juan Podadera, Lara A Boland
CASE SERIES SUMMARY: Four confirmed cases of xanthinuria in cats, and one suspected case based on pedigree analysis, were identified. Clinical presentations varied and included haematuria, pollakiuria, dysuria, and urethral and ureteral obstruction. All cats had upper urinary tract uroliths. Diagnosis was obtained through infrared mass spectrometry of uroliths or urine. Clinical signs commenced at 3-8 months of age and reduced in all cats in the medium to long term after the introduction of a protein-restricted diet...
May 2024: Journal of Feline Medicine and Surgery
#2
JOURNAL ARTICLE
Line Hjort, Sandra Stokholm Bredgaard, Eleonora Manitta, Irene Marques, Anja Elaine Sørensen, David Martino, Louise Groth Grunnet, Louise Kelstrup, Azadeh Houshmand-Oeregaard, Tine Dalsgaard Clausen, Elisabeth Reinhardt Mathiesen, Sjurdur Frodi Olsen, Richard Saffery, Romain Barrès, Peter Damm, Allan Arthur Vaag, Louise Torp Dalgaard
BACKGROUND: Diabetes in pregnancy is associated with increased risk of long-term metabolic disease in the offspring, potentially mediated by in utero epigenetic variation. Previously, we identified multiple differentially methylated single CpG sites in offspring of women with gestational diabetes mellitus (GDM), but whether stretches of differentially methylated regions (DMRs) can also be identified in adolescent GDM offspring is unknown. Here, we investigate which DNA regions in adolescent offspring are differentially methylated in blood by exposure to diabetes in pregnancy...
May 7, 2024: Clinical Epigenetics
#3
JOURNAL ARTICLE
Carolyn A Young, Dawn Langdon, David Rog, Suresh Kumar Chhetri, Radu Tanasescu, Seema Kalra, Gillian Webster, Richard Nicholas, Helen L Ford, John Woolmore, David Paling, Alan Tennant, Roger Mills
BACKGROUND: The prevalence of depression in Multiple Sclerosis (MS) is often assessed by administering patient reported outcome measures (PROMs) examining depressive symptomatology to population cohorts; a recent review summarised 12 such studies, eight of which used the Hospital Anxiety and Depression Scale-Depression (HADS-D). In clinical practice, depression is diagnosed by an individual structured clinical interview; diagnosis often leads to treatment options including antidepressant medication...
April 26, 2024: Multiple Sclerosis and related Disorders
#4
COMPARATIVE STUDY
Enoch Aninagyei, John Gameli Deku, Keren Trishia Yemofio, Ekua Quainoo, Kofi Adjei Ntiri, Evelyn Yaro, Priscilla Essandoh, Hubert Kwame Agbogli, Richard Harry Asmah
Malaria rapid diagnostic test (mRDT) kit is one of the techniques for diagnosing malaria. Due to its inherent advantages over the microscopy technique, several brands of the kit have flooded malaria endemic countries, without prior in-country evaluation. Two of such mRDT kits are Oscar (India) and Standard Q (Korea Republic). In this study, the performance of Oscar and Standard Q mRDT kits were compared to First Response (India) and CareStart (USA) mRDTs, which have been evaluated and deployed for use approved by the Ministry of Health (MOH)...
2024: PloS One
#5
JOURNAL ARTICLE
Rachel S Gross, Tanayott Thaweethai, Erika B Rosenzweig, James Chan, Lori B Chibnik, Mine S Cicek, Amy J Elliott, Valerie J Flaherman, Andrea S Foulkes, Margot Gage Witvliet, Richard Gallagher, Maria Laura Gennaro, Terry L Jernigan, Elizabeth W Karlson, Stuart D Katz, Patricia A Kinser, Lawrence C Kleinman, Michelle F Lamendola-Essel, Joshua D Milner, Sindhu Mohandas, Praveen C Mudumbi, Jane W Newburger, Kyung E Rhee, Amy L Salisbury, Jessica N Snowden, Cheryl R Stein, Melissa S Stockwell, Kelan G Tantisira, Moriah E Thomason, Dongngan T Truong, David Warburton, John C Wood, Shifa Ahmed, Almary Akerlundh, Akram N Alshawabkeh, Brett R Anderson, Judy L Aschner, Andrew M Atz, Robin L Aupperle, Fiona C Baker, Venkataraman Balaraman, Dithi Banerjee, Deanna M Barch, Arielle Baskin-Sommers, Sultana Bhuiyan, Marie-Abele C Bind, Amanda L Bogie, Tamara Bradford, Natalie C Buchbinder, Elliott Bueler, Hülya Bükülmez, B J Casey, Linda Chang, Maryanne Chrisant, Duncan B Clark, Rebecca G Clifton, Katharine N Clouser, Lesley Cottrell, Kelly Cowan, Viren D'Sa, Mirella Dapretto, Soham Dasgupta, Walter Dehority, Audrey Dionne, Kirsten B Dummer, Matthew D Elias, Shari Esquenazi-Karonika, Danielle N Evans, E Vincent S Faustino, Alexander G Fiks, Daniel Forsha, John J Foxe, Naomi P Friedman, Greta Fry, Sunanda Gaur, Dylan G Gee, Kevin M Gray, Stephanie Handler, Ashraf S Harahsheh, Keren Hasbani, Andrew C Heath, Camden Hebson, Mary M Heitzeg, Christina M Hester, Sophia Hill, Laura Hobart-Porter, Travis K F Hong, Carol R Horowitz, Daniel S Hsia, Matthew Huentelman, Kathy D Hummel, Katherine Irby, Joanna Jacobus, Vanessa L Jacoby, Pei-Ni Jone, David C Kaelber, Tyler J Kasmarcak, Matthew J Kluko, Jessica S Kosut, Angela R Laird, Jeremy Landeo-Gutierrez, Sean M Lang, Christine L Larson, Peter Paul C Lim, Krista M Lisdahl, Brian W McCrindle, Russell J McCulloh, Kimberly McHugh, Alan L Mendelsohn, Torri D Metz, Julie Miller, Elizabeth C Mitchell, Lerraughn M Morgan, Eva M Müller-Oehring, Erica R Nahin, Michael C Neale, Manette Ness-Cochinwala, Sheila M Nolan, Carlos R Oliveira, Onyekachukwu Osakwe, Matthew E Oster, R Mark Payne, Michael A Portman, Hengameh Raissy, Isabelle G Randall, Suchitra Rao, Harrison T Reeder, Johana M Rosas, Mark W Russell, Arash A Sabati, Yamuna Sanil, Alice I Sato, Michael S Schechter, Rangaraj Selvarangan, S Kristen Sexson Tejtel, Divya Shakti, Kavita Sharma, Lindsay M Squeglia, Shubika Srivastava, Michelle D Stevenson, Jacqueline Szmuszkovicz, Maria M Talavera-Barber, Ronald J Teufel, Deepika Thacker, Felicia Trachtenberg, Mmekom M Udosen, Megan R Warner, Sara E Watson, Alan Werzberger, Jordan C Weyer, Marion J Wood, H Shonna Yin, William T Zempsky, Emily Zimmerman, Benard P Dreyer
IMPORTANCE: The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or "Long COVID") in children and young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, and potential treatment targets in children and young adults. OBSERVATIONS: We describe the protocol for the Pediatric Observational Cohort Study of the NIH's REsearching COVID to Enhance Recovery (RECOVER) Initiative...
2024: PloS One
#6
JOURNAL ARTICLE
Lucy Coombes, Debbie Braybrook, Daney Harðardóttir, Hannah May Scott, Katherine Bristowe, Clare Ellis-Smith, Lorna K Fraser, Julia Downing, Myra Bluebond-Langner, Fliss Em Murtagh, Richard Harding
BACKGROUND: The Children's Palliative Outcome Scale (C-POS) is being developed using best methodological guidance on outcome measure development, This recommends cognitive testing, an established method of item improvement, prior to psychometric testing. AIM: To cognitively test C-POS within the target population to establish comprehensibility, comprehensiveness, relevance and acceptability. DESIGN: Cross-sectional cognitive interview study following COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology and Rothrock guidance on outcome measure development...
May 6, 2024: Palliative Medicine
#7
JOURNAL ARTICLE
Richard Wiseman, Caroline Watt
Watching a magic trick is a unique experience in which seemingly impossible events appear possible but without any suspension of disbelief. Unfortunately, relatively little work has examined the psychological impact of this fascinating experience. In the current study, participants first completed a measure of the degree to which they disliked magic (Loathing of Legerdemain Scale: LOLS) and then watched a video that either contained a series of magic tricks (magic video) or carefully matched non-magic tricks (control video)...
2024: PeerJ
#8
JOURNAL ARTICLE
Robert W Turer, Samuel A McDonald, Christoph U Lehmann, Bhaskar Thakur, Sayon Dutta, Richard A Taylor, Christian C Rose, Adam Frisch, Kristian Feterik, Craig Norquist, Carrie K Baker, Jeffrey A Nielson, David Cha, Brian Kwan, Christian Dameff, James P Killeen, Michael K Hall, Robert C Doerning, S Trent Rosenbloom, Casey Distaso, Bryan D Steitz
IMPORTANCE: Patients with inequitable access to patient portals frequently present to emergency departments (EDs) for care. Little is known about portal use patterns among ED patients. OBJECTIVES: To describe real-time patient portal usage trends among ED patients and compare demographic and clinical characteristics between portal users and nonusers. DESIGN, SETTING, AND PARTICIPANTS: In this cross-sectional study of 12 teaching and 24 academic-affiliated EDs from 8 health systems in California, Connecticut, Massachusetts, Ohio, Tennessee, Texas, and Washington, patient portal access and usage data were evaluated for all ED patients 18 years or older between April 5, 2021, and April 4, 2022...
May 1, 2024: JAMA Network Open
#9
REVIEW
Christopher J De Jonge, Christopher L R Barratt, R John Aitken, Richard A Anderson, Peter Baker, David Y L Chan, Mark P Connolly, Michael L Eisenberg, Nicolas Garrido, Niels Jørgensen, Sarah Kimmins, Csilla Krausz, Robert I McLachlan, Craig Niederberger, Moira K O'Bryan, Allan Pacey, Lærke Priskorn, Satu Rautakallio-Hokkanen, Gamal Serour, Joris A Veltman, Donna L Vogel, Mónica H Vazquez-Levin
BACKGROUND: The widespread interest in male reproductive health (MRH), fueled by emerging evidence, such as the global decline in sperm counts, has intensified concerns about the status of MRH. Consequently, there is a pressing requirement for a strategic, systematic approach to identifying critical questions, collecting pertinent information, and utilizing these data to develop evidence-based strategies. The methods for addressing these questions and the pathways toward their answers will inevitably vary based on the variations in cultural, geopolitical, and health-related contexts...
2024: Human Reproduction Open
#10
REVIEW
Alberto Papi, Bradley E Chipps, Richard Beasley, Reynold A Panettieri, Elliot Israel, Mark Cooper, Lynn Dunsire, Allison Jeynes-Ellis, Robert Rees, Frank C Albers, Christy Cappelletti
What is this summary about? This summary describes the results of a clinical study called MANDALA that was published in the New England Journal of Medicine in 2022. In the MANDALA study, researchers looked at a new asthma rescue inhaler that contains both albuterol and budesonide in a single inhaler (known as albuterol-budesonide , AIRSUPRA™). This summary describes the results for people aged 18 yearsand older who took part in the study.
2024: Therapeutic Advances in Respiratory Disease
#11
RANDOMIZED CONTROLLED TRIAL
Nina Magnolo, Michael C Cameron, Mona Shahriari, Bob Geng, Brian M Calimlim, Henrique Teixeira, Xiaofei Hu, Yang Yang, Yingyi Liu, Shiyu Zhang, Cristina Sancho Sanchez, Katherine Altman, Richard G Langley
Purpose: Atopic dermatitis (AD) adversely impacts quality of life (QoL). We evaluated the effect of upadacitinib, an oral selective Janus kinase inhibitor approved for moderate-to-severe AD, plus topical corticosteroids (+TCS) on patient-reported outcomes (PROs) over 52 weeks. Materials and methods: In the phase 3 AD Up study (NCT03568318), adults and adolescents with moderate-to-severe AD were randomized 1:1:1 to once-daily upadacitinib 15 mg, 30 mg, or placebo + TCS. Itch, skin pain/symptoms, sleep, QoL, daily activities, emotional state, mental health, and patient impressions of disease severity/improvement/treatment satisfaction were assessed...
December 2024: Journal of Dermatological Treatment
#12
JOURNAL ARTICLE
Yi Liu, Anthony Flamier, George W Bell, Annette Jun Diao, Troy W Whitfield, Hao-Che Wang, Yizhe Wu, Fabian Schulte, Max Friesen, Ruisi Guo, Maisam Mitalipova, X Shawn Liu, Seychelle M Vos, Richard A Young, Rudolf Jaenisch
Mutations in the methyl-DNA-binding protein MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). How MECP2 contributes to transcriptional regulation in normal and disease states is unresolved; it has been reported to be an activator and a repressor. We describe here the first integrated CUT&Tag, transcriptome, and proteome analyses using human neurons with wild-type (WT) and mutant MECP2 molecules. MECP2 occupies CpG-rich promoter-proximal regions in over four thousand genes in human neurons, including a plethora of autism risk genes, together with RNA polymerase II (RNA Pol II)...
April 30, 2024: Neuron
#13
JOURNAL ARTICLE
Richard Kwame Ansah, Sampson Tackie, Rhodaline Abena Twum, Kassim Tawiah, Richard Kena Boadi, Dorcas Attuabea Addo, Samuel Effah-Poku, David Delali Zigli
Studies have indicated that the risk of malaria, particularly its association with anaemia in pregnant women, increases when treated bed nets are not used. This paper utilizes a statistical mechanical model to investigate whether there is a statistical relationship between the presence or absence of anaemia in pregnant and non-pregnant women and their decision to sleep under treated bed nets. Data from the Ghana Malaria Indicator Survey (GMIS), which includes both rural and urban malaria-endemic areas in Ghana, were employed in this study...
2024: PloS One
#14
JOURNAL ARTICLE
Frank J Schwebel, Matthew R Pearson, Dylan K Richards, Connor J McCabe, Verlin W Joseph
Machine learning algorithms hold promise for developing precision medicine approaches to addiction treatment yet have been used sparingly to identify predictors of alcohol-related problems. Recursive partitioning, a machine learning algorithm, can identify salient predictors and clinical cut points that can guide treatment. This study aimed to identify predictors and cut points of alcohol-related problems and to examine result stability in two separate, large data sets of college student drinkers ( n = 5,090 and 2,808)...
May 2, 2024: Experimental and Clinical Psychopharmacology
#15
JOURNAL ARTICLE
Huei-Jiuan Wu, Sophy TingFang Shih, Tanya L Applegate, Jisoo A Kwon, Evan B Cunningham, Jason Grebely, Richard T Gray
INTRODUCTION: Simplified hepatitis C virus (HCV) diagnostic strategies have the potential to improve HCV diagnoses and treatment. We aimed to investigate the impact of simplified HCV diagnostic strategies on HCV incidence and its effect on HCV diagnosis and treatment among men who have sex with men (MSM) regardless of HIV status and use of HIV pre-exposure prophylaxis (PrEP) in Taiwan. METHODS: A compartmental deterministic model was developed to describe the natural history of HCV disease progression, the HCV care cascade and the HIV status and PrEP using among MSM...
May 2024: Journal of the International AIDS Society
#16
JOURNAL ARTICLE
Scott A Fisher, Kimberley Patrick, Tracy Hoang, Elly Marcq, Kiarash Behrouzfar, Sylvia Young, Timothy J Miller, Bruce W S Robinson, Raphael Bueno, Anna K Nowak, W Joost Lesterhuis, Grant Morahan, Richard A Lake
Objectives: This study combines two innovative mouse models in a major gene discovery project to assess the influence of host genetics on asbestos related disease (ARD). Conventional genetics studies provided evidence that some susceptibility to mesothelioma is genetic. However, the identification of host modifier genes, the roles they may play, and whether they contribute to disease susceptibility remain unknown. Here we report a study designed to rapidly identify genes associated with mesothelioma susceptibility by combining the Collaborative Cross (CC) resource with the well-characterised MexTAg mesothelioma mouse model...
2024: Frontiers in toxicology
#17
RANDOMIZED CONTROLLED TRIAL
Ben Beaglehole, Richard Porter, Katie Douglas, Cameron James Lacey, Aroha de Bie, Jennifer Jordan, Charlie Mentzel, Bridgette Thwaites, Jenni Manuel, Greg Murray, Christopher Frampton, Paul Glue
INTRODUCTION: Although short-term benefits follow parenteral ketamine for treatment-resistant major depressive disorder (TR-MDD), there are challenges that prevent routine use of ketamine by clinicians. These include acute dissociative effects of parenteral ketamine, high relapse rates following ketamine dosing and the uncertain role of psychotherapy. This randomised controlled trial (RCT) seeks to establish the feasibility of evaluating repeated oral doses of ketamine and behavioural activation therapy (BAT), compared with ketamine treatment alone, for TR-MDD...
May 1, 2024: BMJ Open
#18
JOURNAL ARTICLE
Nikita Simms-Williams, Prasad Nagakumar, Rasiah Thayakaran, Nicola J Adderley, Richard Hotham, Adel H Mansur, Krishnarajah Nirantharakumar, Shamil Haroon
BACKGROUND: Asthma remains a common cause of hospital admissions across the life course. We estimated the contribution of key risk factors to asthma-related hospital and intensive care unit (ICU) admissions in children, adolescents and adults. METHODS: This was a UK-based cohort study using linked primary care (Clinical Practice Research Datalink Aurum) and secondary care (Hospital Episode Statistics Admitted Patient Care) data. Patients were eligible if they were aged 5 years and older and had been diagnosed with asthma...
May 1, 2024: BMJ Open Respiratory Research
#19
JOURNAL ARTICLE
Jamie Perin, Jennifer Anders, Ashle Barfield, Charlotte Gaydos, Richard Rothman, Pamela A Matson, Steven Huettner, Jacquelyn Toppins, Maria Trent
BACKGROUND: COVID-19 stay-at-home orders and research restrictions halted recruitment and follow-up of clinical research patients. While clinical research has resumed, it is an open question whether research participation has returned to levels similar to those before COVID-19. METHODS: We utilized data from the TECH-PN (NCT# NCT03828994) study, a single-center RCT enrolling 13-25-year-olds with mild-moderate pelvic inflammatory disease (PID) receiving ambulatory care...
May 1, 2024: Sexually Transmitted Diseases
#20
JOURNAL ARTICLE
Nicole Richard Williams, Luc Tremblay, Corene Hurt-Thaut, Jessica Brian, Julia Kowaleski, Kathrin Mertel, Sebastian Shlüter, Michael Thaut
INTRODUCTION: Autistic individuals demonstrate greater variability and timing error in their motor performance than neurotypical individuals, likely due at least in part to atypical cerebellar characteristics and connectivity. These motor difficulties may differentially affect discrete as opposed to continuous movements in autistic individuals. Augmented auditory feedback has the potential to aid motor timing and variability due to intact auditory-motor pathways in autism and high sensitivity in autistic individuals to auditory stimuli...
2024: Frontiers in Integrative Neuroscience
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