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Jae Myung Cha, Danielle La Selva, Richard A Kozarek, Michael Gluck, Andrew Ross, Otto S Lin
BACKGROUND AND AIMS: For young individuals (<40) without strong family histories that would put them at risk for genetic colorectal cancer syndromes, it is unclear if national Multi-Society Task Force surveillance recommendations apply or if endoscopists follow these guideline recommendations when such patients are incidentally found to have adenoma(s) on colonoscopy. METHODS: We reviewed records on young (<40-year-old) patients, with either no family history or only a "moderate" family history (one first-degree family member with colorectal cancer at age ≥50), who were found to have neoplastic polyp(s) on their index colonoscopy...
June 13, 2018: Gastrointestinal Endoscopy
Lei Yu, Vladislav A Petyuk, Chris Gaiteri, Sara Mostafavi, Tracy Young-Pearse, Raj C Shah, Aron S Buchman, Julie A Schneider, Paul D Piehowski, Ryan L Sontag, Thomas L Fillmore, Tujin Shi, Richard D Smith, Philip L De Jager, David A Bennett
OBJECTIVE: Previous gene expression analysis identified a network of co-expressed genes that is associated with β-amyloid neuropathology and cognitive decline in older adults. The current work targeted influential genes in this network with quantitative proteomics to identify potential novel therapeutic targets. METHODS: Data came from 834 community-based older persons who were followed annually, died and underwent brain autopsy. Uniform structured postmortem evaluations assessed the burden of β-amyloid and other common age-related neuropathologies...
June 16, 2018: Annals of Neurology
Marvin Gonzalez-Quiroz, Evangelia-Theano Smpokou, Richard J Silverwood, Armando Camacho, Dorien Faber, Brenda La Rosa Garcia, Amin Oomatia, Michael Hill, Jason Glaser, Jennifer Le Blond, Catharina Wesseling, Aurora Aragon, Liam Smeeth, Neil Pearce, Dorothea Nitsch, Ben Caplin
Background Epidemic levels of CKD of undetermined cause, termed Mesoamerican nephropathy in Central America, have been found in low- and middle-income countries. We investigated the natural history of, and factors associated with, loss of kidney function in a population at high risk for this disease. Methods We conducted a 2-year prospective, longitudinal study with follow-up every 6 months in nine rural communities in northwestern Nicaragua and included all men ( n =263) and a random sample of women ( n =87) ages 18-30 years old without self-reported CKD, diabetes, or hypertension...
June 15, 2018: Journal of the American Society of Nephrology: JASN
Monica Rosales Santillan, Jessica B Dietert, Richard Jahan-Tigh
Papular purpuric gloves and socks syndrome (PPGSS) is a self-limited exanthem that presents as painful or pruritic edema, erythema, petechiae, and purpura of the palms and soles with occasional extension to the dorsal hands and feet. The majority of PPGSS cases reported in the literature are associated with parvovirus B19 and occur in children and young adults. In a recent literature search, there were 11 PPGSS cases in adults with none reporting Epstein-Barr virus (EBV) as a viral etiology. However, there have been PPGSS cases related to EBV in children...
April 15, 2018: Dermatology Online Journal
Jennifer S Sherry, Sandra K Collins, Richard C McKinnies, Anthony Fleege, Marcea L Walter
In the United States, an estimated 20 million people, or 15% of the population, are currently infected with human papilloma virus (HPV). The prevalence of HPV is increasing in females aged 14 to 24 years. Assessing allied health students' knowledge, attitudes, and behaviors regarding HPV was performed using a 34-question survey. The survey was in four sections: general information, measuring knowledge of HPV and the vaccine, HPV vaccine, and HPV screening and diagnosis. Physicians were noted by 31.6% of the participants as the first individual who gave them information about HPV...
June 14, 2018: Health Care Manager
Richard S Kwon, Raquel E Davila, Daniel K Mullady, Mohammad A Al-Haddad, Ji Young Bang, Juliane Bingener-Casey, Brian P Bosworth, Jennifer A Christie, Gregory A Cote, Sarah Diamond, Jennifer Jorgensen, Thomas E Kowalski, Nisa Kubiliun, Joanna K Law, Keith L Obstein, Waqar A Qureshi, Francisco C Ramirez, Robert E Sedlack, Franklin Tsai, Shivakumar Vignesh, Mihir S Wagh, Daniel Zanchetti, Walter J Coyle, Jonathan Cohen
No abstract text is available yet for this article.
July 2017: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Laura Kann, Tim McManus, William A Harris, Shari L Shanklin, Katherine H Flint, Barbara Queen, Richard Lowry, David Chyen, Lisa Whittle, Jemekia Thornton, Connie Lim, Denise Bradford, Yoshimi Yamakawa, Michelle Leon, Nancy Brener, Kathleen A Ethier
PROBLEM: Health-risk behaviors contribute to the leading causes of morbidity and mortality among youth and adults in the United States. In addition, significant health disparities exist among demographic subgroups of youth defined by sex, race/ethnicity, and grade in school and between sexual minority and nonsexual minority youth. Population-based data on the most important health-related behaviors at the national, state, and local levels can be used to help monitor the effectiveness of public health interventions designed to protect and promote the health of youth at the national, state, and local levels...
June 15, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
Curtis H Kugel, Stephen M Douglass, Marie R Webster, Amanpreet Kaur, Qin Liu, Xiangfan Yin, Sarah A Weiss, Farbod Darvishian, Rami N Al-Rohil, Abibatou Ndoye, Reeti Behera, Gretchen M Alicea, Brett L Ecker, Mitchell Fane, Michael J Allegrezza, Nikolaos Svoronos, Vinit Kumar, Daniel Y Wang, Rajasekharan Somasundaram, Siwen Hu-Lieskovan, Alpaslan Ozgun, Meenhard Herlyn, Jose R Conejo-Garcia, Dmitry Gabrilovich, Erica L Stone, Theodore S Nowicki, Jeffrey Sosman, Rajat Rai, Matteo S Carlino, Georgina V Long, Richard Marais, Antoni Ribas, Zeynep Eroglu, Michael A Davies, Bastian Schilling, Dirk Schadendorf, Wei Xu, Ravi K Amaravadi, Alexander M Menzies, Jennifer L McQuade, Douglas B Johnson, Iman Osman, Ashani T Weeraratna
Purpose: We have shown that the aged microenvironment increases melanoma metastasis, and decreases response to targeted therapy, and here we queried response to anti-PD1. Experimental Design: We analyzed the relationship between age, response to anti-PD1, and prior therapy in 538 patients. We used mouse models of melanoma, to analyze the intratumoral immune microenvironment in young versus aged mice and confirmed our findings in human melanoma biopsies. Results: Patients over the age of 60 responded more efficiently to anti-PD-1, and likelihood of response to anti-PD-1 increased with age, even when we controlled for prior MAPKi therapy...
June 13, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Paul Kligfield, Fabio Badilini, Isabelle Denjoy, Saeed Babaeizadeh, Elaine Clark, Johan De Bie, Brian Devine, Fabrice Extramiana, Gianluca Generali, Richard Gregg, Eric Helfenbein, Jan Kors, Remo Leber, Peter Macfarlane, Pierre Maison-Blanche, Ian Rowlandson, Ramun Schmid, Martino Vaglio, Gerard van Herpen, Joel Xue, Brian Young, Cynthia L Green
BACKGROUND: Automated measurements of electrocardiographic (ECG) intervals by current-generation digital electrocardiographs are critical to computer-based ECG diagnostic statements, to serial comparison of ECGs, and to epidemiological studies of ECG findings in populations. A previous study demonstrated generally small but often significant systematic differences among 4 algorithms widely used for automated ECG in the United States and that measurement differences could be related to the degree of abnormality of the underlying tracing...
June 2018: American Heart Journal
François Bilodeau, Mara Brendgen, Frank Vitaro, Sylvana M Côté, Richard E Tremblay, Evelyne Touchette, Jacques Montplaisir, Michel Boivin
This study examined the moderating role of parental behaviors in the longitudinal link between peer victimization and sleep problems during preschool. The sample consisted of 1,181 children (594 girls) attending day care between the ages of 3 and 6 years. Participants were part of the Quebec Longitudinal Study of Child Development, a longitudinal study of child development led by the Institut de la Statistique du Quebec. Controlling for potential confounders, latent growth curve analyses revealed that the association between peer victimization and sleep problems varied depending on parents' behaviors...
June 11, 2018: Journal of Clinical Child and Adolescent Psychology
George Vasquez-Rios, Lesly Calixto-Aguilar, Richard Pajuelo, Wilder Alarcon
Introduction: Thoracic empyema is an infrequent complication of appendicitis that has rarely been reported in the literature. Case Presentation and Review of the Literature: The case of a 11-year-old boy who was admitted for medical management of an appendicular mass is presented. His clinical course was complicated by the development of an appendicular abscess and an extensive right-sided empyema. A comprehensive review of the literature was conducted including the most representative cases...
2018: Case Reports in Pediatrics
Richard Johansen, Richard Beck, Jakub Nowosad, Christopher Nietch, Min Xu, Song Shu, Bo Yang, Hongxing Liu, Erich Emery, Molly Reif, Joseph Harwood, Jade Young, Dana Macke, Mark Martin, Garrett Stillings, Richard Stumpf, Haibin Su
This study evaluated the performances of twenty-nine algorithms that use satellite-based spectral imager data to derive estimates of chlorophyll-a concentrations that, in turn, can be used as an indicator of the general status of algal cell densities and the potential for a harmful algal bloom (HAB). The performance assessment was based on making relative comparisons between two temperate inland lakes: Harsha Lake (7.99 km2 ) in Southwest Ohio and Taylorsville Lake (11.88 km2 ) in central Kentucky. Of interest was identifying algorithm-imager combinations that had high correlation with coincident chlorophyll-a surface observations for both lakes, as this suggests portability for regional HAB monitoring...
June 2018: Harmful Algae
Louise Roper, Frances C Sherratt, Bridget Young, Paul McNamara, Angus Dawson, Richard Appleton, Esther Crawley, Lucy Frith, Carrol Gamble, Kerry Woolfall
OBJECTIVES: We explored children's views on research without prior consent (RWPC) and sought to identify ways of involving children in research discussions. DESIGN: Qualitative interview study. SETTING: Participants were recruited through a UK children's hospital and online advertising. PARTICIPANTS: 16 children aged 7-15 years with a diagnosis of asthma (n=14) or anaphylaxis (n=2) with recent (<12 months) experience of emergency care...
June 9, 2018: BMJ Open
Joanne D Worsley, Jason C McIntyre, Richard P Bentall, Rhiannon Corcoran
Childhood maltreatment is associated with many maladaptive outcomes. This study sought to examine the association between childhood maltreatment and problematic social media use using a cross-sectional sample of young adults aged 17-25 years (n = 1029). Specifically, we studied whether the relationship is mediated through (i) attachment anxiety, (ii) attachment avoidance, or (iii) both attachment dimensions operating in series with depressive symptoms. Results revealed that a history of childhood maltreatment was significantly associated with more problematic social media use...
May 25, 2018: Psychiatry Research
Yu Song, Yi Gan, Liangyu Liu, Richard T Corlett
Machilus yunnanensis Lecomte is an important Chinese timber species in the family Lauraceae, subclass Magnoliidae. To understand the genetic and molecular basis of flowering in M. yunnanensis, we applied RNA-seq for transcriptome analysis of young and mature flowers and compared these with the transcriptome of leaves. From approximately 26 Gb Illumina clean reads, we obtained a total of 85 823 high-quality transcripts using Trinity software. Comparisons of gene expression in young and mature flowers showed that 37 877 genes were differentially expressed...
May 12, 2018: Computational Biology and Chemistry
Manjit S Mehat, Venki Sundaram, Caterina Ripamonti, Anthony G Robson, Alexander J Smith, Shyamanga Borooah, Martha Robinson, Adam N Rosenthal, William Innes, Richard G Weleber, Richard W J Lee, Michael Crossland, Gary S Rubin, Baljean Dhillon, David H W Steel, Eddy Anglade, Robert P Lanza, Robin R Ali, Michel Michaelides, James W B Bainbridge
PURPOSE: Transplantation of human embryonic stem cell (hESC)-derived retinal pigment epithelial (RPE) cells offers the potential for benefit in macular degeneration. Previous trials have reported improved visual acuity (VA), but lacked detailed analysis of retinal structure and function in the treated area. DESIGN: Phase 1/2 open-label dose-escalation trial to evaluate safety and potential efficacy ( identifier, NCT01469832). PARTICIPANTS: Twelve participants with advanced Stargardt disease (STGD1), the most common cause of macular degeneration in children and young adults...
June 5, 2018: Ophthalmology
Saverio Caini, Peter Spreeuwenberg, Gabriela F Kusznierz, Juan Manuel Rudi, Rhonda Owen, Kate Pennington, Sonam Wangchuk, Sonam Gyeltshen, Walquiria Aparecida Ferreira de Almeida, Cláudio Maierovitch Pessanha Henriques, Richard Njouom, Marie-Astrid Vernet, Rodrigo A Fasce, Winston Andrade, Hongjie Yu, Luzhao Feng, Juan Yang, Zhibin Peng, Jenny Lara, Alfredo Bruno, Doménica de Mora, Celina de Lozano, Maria Zambon, Richard Pebody, Leticia Castillo, Alexey W Clara, Maria Luisa Matute, Herman Kosasih, Nurhayati, Simona Puzelli, Caterina Rizzo, Herve A Kadjo, Coulibaly Daouda, Lyazzat Kiyanbekova, Akerke Ospanova, Joshua A Mott, Gideon O Emukule, Jean-Michel Heraud, Norosoa Harline Razanajatovo, Amal Barakat, Fatima El Falaki, Sue Q Huang, Liza Lopez, Angel Balmaseda, Brechla Moreno, Ana Paula Rodrigues, Raquel Guiomar, Li Wei Ang, Vernon Jian Ming Lee, Marietjie Venter, Cheryl Cohen, Selim Badur, Meral A Ciblak, Alla Mironenko, Olha Holubka, Joseph Bresee, Lynnette Brammer, Phuong Vu Mai Hoang, Mai Thi Quynh Le, Douglas Fleming, Clotilde El-Guerche Séblain, François Schellevis, John Paget
BACKGROUND: Influenza disease burden varies by age and this has important public health implications. We compared the proportional distribution of different influenza virus types within age strata using surveillance data from twenty-nine countries during 1999-2014 (N=358,796 influenza cases). METHODS: For each virus, we calculated a Relative Illness Ratio (defined as the ratio of the percentage of cases in an age group to the percentage of the country population in the same age group) for young children (0-4 years), older children (5-17 years), young adults (18-39 years), older adults (40-64 years), and the elderly (65+ years)...
June 8, 2018: BMC Infectious Diseases
Brett Bowman, Sherianne Kramer, Sulaiman Salau, Ella Kotze, Richard Matzopoulos
OBJECTIVES: South Africa has high rates of violence. The country has benefitted enormously from the use of injury surveillance data from the health sector, but there is a need to explore other avenues of routine data to advance violence prevention. We demonstrate the value of using routinely collected police data for enhancing our understanding of robbery as an important situational context for violence in South Africa. METHODS: We analysed 1,841,253 cases reported to the police between 2003 and 2014 to describe the distribution and predictors of robbery violence in South Africa...
June 7, 2018: International Journal of Public Health
Tomoya Hirota, Ryuhei So, Young Shin Kim, Bennett Leventhal, Richard A Epstein
BACKGROUND: Existing reviews of screening tools for Autism Spectrum Disorder (ASD) focus on young children, and not all screening tools have been examined against validated diagnostic procedures. AIMS: To examine the validity of screening tools for ASD in non-young children and adults to provide clinical recommendations about the use of these tools in a variety of clinical settings. METHODS AND PROCEDURES: Electronic databases, including MEDLINE, EMBASE, PsychINFO, Cochrane Library and CINAHL, were searched through March 2017...
June 4, 2018: Research in Developmental Disabilities
Richard M Rosenfeld
No abstract text is available yet for this article.
June 7, 2018: JAMA Otolaryngology—Head & Neck Surgery
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