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https://www.readbyqxmd.com/read/28211184/night-time-pedestrian-conspicuity-effects-of-clothing-on-drivers-eye-movements
#1
Joanne M Wood, Richard A Tyrrell, Philippe Lacherez, Alex A Black
PURPOSE: Drivers' responses and eye movements were assessed as they approached pedestrians at night in order to explore the relative conspicuity benefits of different configurations of retroreflective markings. METHODS: Eye movements were recorded using an ASL Mobile Eye (Applied Science Technologies, www.asleyetracking.com) from 14 young licensed drivers (M = 24.1 ± 6.4 years) as they drove along a closed-road circuit at night. At two locations, pedestrians walked in place facing either towards or away from the road...
March 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28209327/outcomes-of-total-shoulder-arthroplasty-in-patients-younger-than-65-years-a-systematic-review
#2
REVIEW
Troy A Roberson, Jared C Bentley, James T Griscom, Michael J Kissenberth, Stefan J Tolan, Richard J Hawkins, John M Tokish
BACKGROUND: Despite concerns about the longevity of total shoulder arthroplasty (TSA) in young patients, it remains an attractive option because of the absence of superior options. METHODS: A systematic review was performed using searches of PubMed, Embase, and Cochrane databases. English-language studies were identified with search terms "total shoulder arthroplasty" (title/abstract) or "shoulder replacement" (title/abstract) and "young" (title/abstract) or "under 65 years of age" (title/abstract)...
February 10, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28207729/proposed-new-industry-code-on-unhealthy-food-marketing-to-children-and-young-people-will-it-make-a-difference
#3
Boyd Swinburn, Stefanie Vandevijvere, Alistair Woodward, Andrew Hornblow, Ann Richardson, Barbara Burlingame, Barry Borman, Barry Taylor, Bernhard Breier, Bruce Arroll, Bernadette Drummond, Cameron Grant, Chris Bullen, Clare Wall, Cliona Ni Mhurchu, David Cameron-Smith, David Menkes, David Murdoch, Dee Mangin, Diana Lennon, Diana Sarfati, Doug Sellman, Elaine Rush, Faafetai Sopoaga, George Thomson, Gerry Devlin, Gillian Abel, Harvey White, Jane Coad, Janet Hoek, Jennie Connor, Jeremy Krebs, Jeroen Douwes, Jim Mann, John McCall, John Broughton, John D Potter, Les Toop, Lesley McCowan, Louise Signal, Lutz Beckert, Mark Elwood, Marlena Kruger, Mauro Farella, Michael Baker, Michael Keall, Murray Skeaff, Murray Thomson, Nick Wilson, Nicholas Chandler, Papaarangi Reid, Patricia Priest, Paul Brunton, Peter Crampton, Peter Davis, Philip Gendall, Philippa Howden-Chapman, Rachael Taylor, Richard Edwards, Robert Beaglehole, Robert Doughty, Robert Scragg, Robin Gauld, Robert McGee, Rod Jackson, Roger Hughes, Roger Mulder, Ruth Bonita, Rozanne Kruger, Sally Casswell, Sarah Derrett, Shanthi Ameratunga, Simon Denny, Simon Hales, Sue Pullon, Susan Wells, Tim Cundy, Tony Blakely
Reducing the exposure of children and young people to the marketing of unhealthy foods is a core strategy for reducing the high overweight and obesity prevalence in this population. The Advertising Standards Authority (ASA) has recently reviewed its self-regulatory codes and proposed a revised single code on advertising to children. This article evaluates the proposed code against eight criteria for an effective code, which were included in a submission to the ASA review process from over 70 New Zealand health professors...
February 17, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28198637/video-gaming-and-gaming-addiction-in-transgender-people-an-exploratory-study
#4
Jon Arcelus, Walter Pierre Bouman, Bethany Alice Jones, Christina Richards, Susana Jimenez-Murcia, Mark D Griffiths
Background There is anecdotal clinical evidence that transgender people use the online world - such as forums and online video gaming - for the purpose of experiencing their gender identity in a safe, non-threatening, non-alienating, non-stigmatizing, and non-critical environment. Aims To describe gaming behavior, degree of problematic gaming behavior and associated factors with problematic gaming in a comparatively large group of transgender people accessing transgender health services. Methods Every individual referred to a national transgender health service in the United Kingdom during a 12-month period was invited to complete a series of questionnaires to measure gaming behavior, interpersonal functioning, severity of autistic features, and anxiety and depressive symptoms...
February 15, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28195328/visualization-of-xylem-embolism-by-x-ray-microtomography-a-direct-test-against-hydraulic-measurements
#5
Markus Nolf, Rosana Lopez, Jennifer M R Peters, Richard J Flavel, Leah S Koloadin, Iain M Young, Brendan Choat
X-ray microtomography (microCT) is becoming a valuable noninvasive tool for advancing our understanding of plant-water relations. Laboratory-based microCT systems are becoming more affordable and provide better access than synchrotron facilities. However, some systems come at the cost of comparably lower signal quality and spatial resolution than synchrotron facilities. In this study, we evaluated laboratory-based X-ray microCT imaging as a tool to nondestructively analyse hydraulic vulnerability to drought-induced embolism in a woody plant species...
February 14, 2017: New Phytologist
https://www.readbyqxmd.com/read/28195122/integrated-genomic-analyses-of-de-novo-pathways-underlying-atypical-meningiomas
#6
Akdes Serin Harmancı, Mark W Youngblood, Victoria E Clark, Süleyman Coşkun, Octavian Henegariu, Daniel Duran, E Zeynep Erson-Omay, Leon D Kaulen, Tong Ihn Lee, Brian J Abraham, Matthias Simon, Boris Krischek, Marco Timmer, Roland Goldbrunner, S Bülent Omay, Jacob Baranoski, Burçin Baran, Geneive Carrión-Grant, Hanwen Bai, Ketu Mishra-Gorur, Johannes Schramm, Jennifer Moliterno, Alexander O Vortmeyer, Kaya Bilgüvar, Katsuhito Yasuno, Richard A Young, Murat Günel
Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic analyses, we compared benign meningiomas to atypical ones. Here, we show that the majority of primary (de novo) atypical meningiomas display loss of NF2, which co-occurs either with genomic instability or recurrent SMARCB1 mutations. These tumours harbour increased H3K27me3 signal and a hypermethylated phenotype, mainly occupying the polycomb repressive complex 2 (PRC2) binding sites in human embryonic stem cells, thereby phenocopying a more primitive cellular state...
February 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/28193763/neurologic-involvement-in-patients-with-atypical-chediak-higashi-disease
#7
Wendy J Introne, Wendy Westbroek, Catherine A Groden, Vikas Bhambhani, Gretchen A Golas, Eva H Baker, Tanya J Lehky, Joseph Snow, Shira G Ziegler, May Christine V Malicdan, David R Adams, Heidi M Dorward, Richard A Hess, Marjan Huizing, William A Gahl, Camilo Toro
OBJECTIVE: To delineate the developmental and progressive neurodegenerative features in 9 young adults with the atypical form of Chediak-Higashi disease (CHD) enrolled in a natural history study. METHODS: Patients with atypical clinical features, but diagnostically confirmed CHD by standard evaluation of blood smears and molecular genotyping, underwent complete neurologic evaluation, MRI of the brain, electrophysiologic examination, and neuropsychological testing...
14, 2017: Neurology
https://www.readbyqxmd.com/read/28192371/somatic-mutations-in-telomerase-promoter-counterbalance-germline-loss-of-function-mutations
#8
Lindley Maryoung, Yangbo Yue, Ashley Young, Chad A Newton, Cindy Barba, Nicolai S C van Oers, Richard C Wang, Christine Kim Garcia
Germline coding mutations in different telomere-related genes have been linked to autosomal-dominant familial pulmonary fibrosis. Individuals with these inherited mutations demonstrate incomplete penetrance of clinical phenotypes affecting the lung, blood, liver, skin, and other organs. Here, we describe the somatic acquisition of promoter mutations in telomerase reverse transcriptase (TERT) in blood leukocytes of approximately 5% of individuals with inherited loss-of-function coding mutations in TERT or poly(A)-specific ribonuclease (PARN), another gene linked to telomerase function...
February 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28187285/transcriptional-addiction-in-cancer
#9
REVIEW
James E Bradner, Denes Hnisz, Richard A Young
Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional programs. These dysregulated programs can cause cancer cells to become highly dependent on certain regulators of gene expression. Here, we discuss how transcriptional control is disrupted by genetic alterations in cancer cells, why transcriptional dependencies can develop as a consequence of dysregulated programs, and how these dependencies provide opportunities for novel therapeutic interventions in cancer.
February 9, 2017: Cell
https://www.readbyqxmd.com/read/28186668/a-post-hoc-study-on-gene-panel-analysis-for-the-diagnosis-of-dystonia
#10
Martje E van Egmond, Coen H A Lugtenberg, Oebele F Brouwer, Maria Fiorella Contarino, Victor S C Fung, M Rebecca Heiner-Fokkema, Jacobus J van Hilten, Annemarie H van der Hout, Kathryn J Peall, Richard J Sinke, Emmanuel Roze, Corien C Verschuuren-Bemelmans, Michel A Willemsen, Nicole I Wolf, Marina A Tijssen, Tom J de Koning
BACKGROUND: Genetic disorders causing dystonia show great heterogeneity. Recent studies have suggested that next-generation sequencing techniques such as gene panel analysis can be effective in diagnosing heterogeneous conditions. The objective of this study was to investigate whether dystonia patients with a suspected genetic cause could benefit from the use of gene panel analysis. METHODS: In this post hoc study, we describe gene panel analysis results of 61 dystonia patients (mean age, 31 years; 72% young onset) in our tertiary referral center...
February 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28184313/juvenile-delinquency-welfare-justice-and-therapeutic-interventions-a-global-perspective
#11
REVIEW
Susan Young, Ben Greer, Richard Church
This review considers juvenile delinquency and justice from an international perspective. Youth crime is a growing concern. Many young offenders are also victims with complex needs, leading to a public health approach that requires a balance of welfare and justice models. However, around the world there are variable and inadequate legal frameworks and a lack of a specialist workforce. The UK and other high-income countries worldwide have established forensic child and adolescent psychiatry, a multifaceted discipline incorporating legal, psychiatric and developmental fields...
February 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28181482/small-genomic-insertions-form-enhancers-that-misregulate-oncogenes
#12
Brian J Abraham, Denes Hnisz, Abraham S Weintraub, Nicholas Kwiatkowski, Charles H Li, Zhaodong Li, Nina Weichert-Leahey, Sunniyat Rahman, Yu Liu, Julia Etchin, Benshang Li, Shuhong Shen, Tong Ihn Lee, Jinghui Zhang, A Thomas Look, Marc R Mansour, Richard A Young
The non-coding regions of tumour cell genomes harbour a considerable fraction of total DNA sequence variation, but the functional contribution of these variants to tumorigenesis is ill-defined. Among these non-coding variants, somatic insertions are among the least well characterized due to challenges with interpreting short-read DNA sequences. Here, using a combination of Chip-seq to enrich enhancer DNA and a computational approach with multiple DNA alignment procedures, we identify enhancer-associated small insertion variants...
February 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28179273/radiation-free-alternative-donor-hct-for-fanconi-anemia-patients-results-from-a-prospective-multi-institutional-study
#13
Parinda A Mehta, Stella M Davies, Thomas Leemhuis, Kasiani Myers, Nancy A Kernan, Susan E Prockop, Andromachi Scaradavou, Richard J O'Reilly, David A Williams, Leslie Lehmann, Eva Guinan, David Margolis, K Scott Baker, Adam Lane, Farid Boulad
Fanconi anemia (FA) is an inherited bone marrow failure syndrome characterized by chromosomal fragility, progressive marrow failure and cancer predisposition. Hematopoietic cell transplantation (HCT) is curative for FA-related marrow failure or leukemia, but both radiation exposure during transplant and graft-versus host disease (GVHD) may increase risk of later malignancies of the head and neck and anogenital area. In this study we tested a radiation-free conditioning regimen with a T-cell depleted graft to eliminate radiation exposure and minimize early as well as late toxicities of transplant...
February 8, 2017: Blood
https://www.readbyqxmd.com/read/28178688/upregulated-wee1-protects-endothelial-cells-of-colorectal-cancer-liver-metastases
#14
Peter J Webster, Anna T Littlejohns, Hannah J Gaunt, Richard S Young, Baptiste Rode, Judith E Ritchie, Lucy F Stead, Sally Harrison, Alastair Droop, Heather L Martin, Darren C Tomlinson, Adam J Hyman, Hollie L Appleby, Sally Boxall, Alexander F Bruns, Jing Li, Raj K Prasad, J Peter A Lodge, Dermot A Burke, David J Beech
Surgical resection of colorectal cancer liver metastases (CLM) can be curative, yet 80% of patients are unsuitable for this treatment. As angiogenesis is a determinant of CLM progression we isolated endothelial cells from CLM and sought a mechanism which is upregulated, essential for angiogenic properties of these cells and relevant to emerging therapeutic options. Matched CLM endothelial cells (CLMECs) and endothelial cells of normal adjacent liver (LiECs) were superficially similar but transcriptome sequencing revealed molecular differences, one of which was unexpected upregulation and functional significance of the checkpoint kinase WEE1...
February 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28174261/identification-of-unique-antigenic-determinants-in-the-amino-terminus-of-ia-2-ica512-in-childhood-and-adult-autoimmune-diabetes-new-biomarker-development
#15
Maria Acevedo-Calado, Eddie A James, Michael P Morran, Susan L Pietropaolo, Qin Ouyang, David Arribas-Layton, Marco Songini, Marco Liguori, Anna Casu, Richard J Auchus, Shuai Huang, Liping Yu, Aaron Michels, Roberto Gianani, Massimo Pietropaolo
OBJECTIVE: The characterization of diverse subtypes of diabetes is a dynamic field of clinical research and an active area of discussion. The objective of this study was to identify new antigenic determinants in the neuroendocrine autoantigen IA-2 (ICA512) and assess whether circulating autoantibodies directed to new IA-2 epitopes identify autoimmune diabetes in young and adult populations with diabetes. RESEARCH DESIGN AND METHODS: Clinically diagnosed patients with type 2 diabetes (n = 258; diabetes duration: 0...
February 7, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28171742/impulsivity-and-its-relationship-with-anxiety-depression-and-stress
#16
Ahmed A Moustafa, Richard Tindle, Dorota Frydecka, Błażej Misiak
We aimed to assess the association between depression, anxiety, stress and impulsivity with respect to age. The Depression, Anxiety and Stress Scale (DASS-42) and the Barratt Impulsiveness Scale (BIS-11) were administered to 145 individuals. Due to a negative correlation between age, BIS-11 and DASS-42 subscales, participants were divided into three groups: young-aged (18-30years), middle-aged (31-49years) and old-aged (≥50years). Subjects from old-aged group had significantly lower scores of depression, anxiety, stress and impulsivity compared to those from younger groups...
January 23, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28169418/allogeneic-transplantation-using-cd34-selected-peripheral-blood-progenitor-cells-combined-with-non-mobilized-donor-t%C3%A2-cells-for-refractory-severe-aplastic-anaemia
#17
Enkhtsetseg Purev, Xin Tian, Georg Aue, Jeremy Pantin, Phuong Vo, Reem Shalabi, Robert N Reger, Lisa Cook, Catalina Ramos, Elena Cho, Tat'yana Worthy, Hanh Khuu, David Stroncek, Neal S Young, Richard W Childs
Allogeneic haematopoietic stem cell transplantation is curative for severe aplastic anaemia (SAA) unresponsive to immunosuppressive therapy. To reduce chronic graft-versus-host disease (GVHD), which occurs more frequently after peripheral blood stem cell (PBSC) transplantation compared to bone-marrow transplantation (BMT), and to prevent graft rejection, we developed a novel partial T-cell depleted transplant that infuses high numbers of granulocyte colony-stimulating factor-mobilized CD34(+) selected PBSCs combined with a BMT-equivalent dose of non-mobilized donor T-cells...
February 7, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28167751/axl-dependent-infection-of-human-fetal-endothelial-cells-distinguishes-zika-virus-from-other-pathogenic-flaviviruses
#18
Audrey Stéphanie Richard, Byoung-Shik Shim, Young-Chan Kwon, Rong Zhang, Yuka Otsuka, Kimberly Schmitt, Fatma Berri, Michael S Diamond, Hyeryun Choe
Although a causal relationship between Zika virus (ZIKV) and microcephaly has been established, it remains unclear why ZIKV, but not other pathogenic flaviviruses, causes congenital defects. Here we show that when viruses are produced in mammalian cells, ZIKV, but not the closely related dengue virus (DENV) or West Nile virus (WNV), can efficiently infect key placental barrier cells that directly contact the fetal bloodstream. We show that AXL, a receptor tyrosine kinase, is the primary ZIKV entry cofactor on human umbilical vein endothelial cells (HUVECs), and that ZIKV uses AXL with much greater efficiency than does DENV or WNV...
February 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28167302/characterization-of-neck-strength-in-healthy-young-adults
#19
Eva Catenaccio, Weiya Mu, Atira Kaplan, Roman Fleysher, Namhee Kim, Tamar Bachrach, Malka Zughaft Sears, Oren Jaspan, Jaclyn Caccese, Mimi Kim, Mark Wagshul, Walter F Stewart, Richard B Lipton, Michael L Lipton
BACKGROUND: The role of cervical muscle (neck) strength in traumatic brain and spine injury and chronic neck pain disorders is an area of active research. Characterization of the normal ranges of neck strength in healthy young adults is essential to designing future investigations of how strength may act as a modifier for risk and progression in head and neck disorders. OBJECTIVE: To develop a normative reference database of neck strength in a healthy young adult population; and to evaluate the relationship of neck strength to anthropometric measurements...
February 3, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28163088/risk-of-luteal-phase-pregnancy-with-any-cycle-day-initiation-of-subdermal-contraceptive-implants
#20
Molly Richards, Stephanie B Teal, Jeanelle Sheeder
OBJECTIVES: To determine rates of luteal phase pregnancy (LPP) in young women initiating subdermal implants on any day of the menstrual cycle. STUDY DESIGN: We assessed a retrospective cohort of young women receiving contraceptive implants at an adolescent Title-X clinic. Patients with negative pregnancy tests were eligible for same-day insertion, regardless of cycle day, contraceptive use, or last intercourse. We computed LPP rates for those within manufacturer guidelines for insertion (≤5 days of menstrual onset or ≤7 days post-discontinuing hormonal contraception) and outside these guidelines...
February 2, 2017: Contraception
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