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https://www.readbyqxmd.com/read/29454263/homeless-youth-barriers-and-facilitators-for-service-referrals
#1
Emma B Black, Izabela E Fedyszyn, Helen Mildred, Rhianna Perkin, Richard Lough, Peter Brann, Cheryl Ritter
Young people who are homeless and experiencing mental health issues are reluctant to use relevant services for numerous reasons. Youth are also at risk of disengaging from services at times of referral to additional or alternative services. This study aimed to identify barriers and facilitators for inter-service referrals for homeless youth with mental health issues who have already engaged with a service. Qualitative, semi-structured interviews were conducted with homeless youth (n = 10), homelessness support workers (n = 10), and mental health clinicians (n = 10)...
February 10, 2018: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29452669/optimal-management-of-the-young-patient-cll-patient
#2
REVIEW
John N Allan, Richard R Furman
The emergence of targeted therapy for patients with chronic lymphocytic leukemia (CLL) has permanently altered the therapeutic landscape. In both upfront and relapsed settings, safe and effective oral kinase inhibitors are available which rival the responses and durability seen with standard chemo immunotherapy regimens. In 2016, ibrutinib was granted Federal Drug Administration approval for first-line therapy in patients with CLL. While its role as initial therapy for older, unfit or deleted 17p CLL patients is less controversial, its role as first-line treatment for younger fit patients is less clear, begging the question, what is the optimal treatment for these patients, novel agents or standard CIT strategies? In this review, we aim to provide guidance for what we believe is the optimal management of young fit patients with CLL...
March 2018: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29451923/to-what-extent-do-potential-conservation-donors-value-community-aspects-of-conservation-projects-in-low-income-countries
#3
Amy R Lewis, Richard P Young, James M Gibbons, Julia P G Jones
There is a major gap in funding required for conservation, especially in low income countries. Given the significant contribution of taxpayers in industrialized countries to funding conservation overseas, and donations from membership organisation, understanding the preferences of ordinary people in a high income country for different attributes of conservation projects is valuable for future marketing of conservation. We conducted a discrete choice experiment with visitors to a UK zoo, while simultaneously conducting a revealed preference study through a real donation campaign on the same sample...
2018: PloS One
https://www.readbyqxmd.com/read/29450479/open-access-is-there-a-predator-at-the-door
#4
Jay F Piccirillo, Rakesh Chandra, Edward W Fisher, Terry M Jones, David W Kennedy, Dennis H Kraus, John H Krouse, Michael Link, Lawrence R Lustig, Bert W O'Malley, Robert Ruben, Robert T Sataloff, Raj Sindwani, Richard J Smith, Michael G Stewart, Peter C Weber, D Bradley Welling, Robin Youngs, M B Bs
No abstract text is available yet for this article.
February 15, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29449178/comment-on-a-pilot-study-of-primary-care-physicians-attitude-to-weight-loss-surgery-in-england-are-the-young-more-prejudiced
#5
EDITORIAL
Richard M Peterson
No abstract text is available yet for this article.
January 31, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29446087/open-access-is-there-a-predator-at-the-door
#6
EDITORIAL
Rakesh Chandra, Edward W Fisher, Terry M Jones, David W Kennedy, Dennis H Kraus, John H Krouse, Michael Link, Lawrence R Lustig, Bert W O'Malley, Jay F Piccirillo, Robert Ruben, Robert T Sataloff, Raj Sindwani, Richard J Smith, Michael G Stewart, Peter C Weber, D Bradley Welling, Robin Youngs
No abstract text is available yet for this article.
February 15, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29444854/bet-bromodomain-proteins-regulate-enhancer-function-during-adipogenesis
#7
Jonathan D Brown, Zachary B Feldman, Sean P Doherty, Jaime M Reyes, Peter B Rahl, Charles Y Lin, Quanhu Sheng, Qiong Duan, Alexander J Federation, Andrew L Kung, Saptarsi M Haldar, Richard A Young, Jorge Plutzky, James E Bradner
Developmental transitions are guided by master regulatory transcription factors. During adipogenesis, a transcriptional cascade culminates in the expression of PPARγ and C/EBPα, which orchestrate activation of the adipocyte gene expression program. However, the coactivators controlling PPARγ and C/EBPα expression are less well characterized. Here, we show the bromodomain-containing protein, BRD4, regulates transcription of PPARγ and C/EBPα. Analysis of BRD4 chromatin occupancy reveals that induction of adipogenesis in 3T3L1 fibroblasts provokes dynamic redistribution of BRD4 to de novo super-enhancers proximal to genes controlling adipocyte differentiation...
February 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29443554/open-access-is-there-a-predator-at-the-door
#8
Rakesh Chandra, Edward W Fisher, Terry M Jones, David W Kennedy, Dennis H Kraus, John H Krouse, Michael Link, Lawrence R Lustig, Bert W O'Malley, Jay F Piccirillo, Robert Ruben, Robert T Sataloff, Sandra Schwartz, Raj Sindwani, Richard J Smith, Michael G Stewart, Peter C Weber, D Bradley Welling, Robin Youngs
No abstract text is available yet for this article.
March 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29442344/comparison-of-essdai-and-clinessdai-in-potential-optimisation-of-trial-outcomes-in-primary-sj%C3%A3-gren-s-syndrome-examination-of-data-from-the-uk-primary-sj%C3%A3-gren-s-syndrome-registry
#9
Alexandre Dumusc, Wan-Fai Ng, Katherine James, Bridget Griffiths, Elizabeth Price, Colin Pease, Paul Emery, Peter Lanyon, Adrian Jones, Michele Bombardieri, Nurhan Sutcliffe, Costantino Pitzalis, Monica Gupta, John McLaren, Annie Cooper, Ian Giles, David Isenberg, Vadivelu Saravanan, David Coady, Bhaskar Dasgupta, Neil McHugh, Steven Young-Min, Robert Moots, Nagui Gendi, Mohammed Akil, Francesca Barone, Benjamin Fisher, Saaeha Rauz, Andrea Richards, Simon Bowman
OBJECTIVES: To assess the use of the Clinical EULAR Sjögren's Syndrome Disease Activity Index (ClinESSDAI), a version of the ESSDAI without the biological domain, for assessing potential eligibility and outcomes for clinical trials in patients with primary Sjögren's syndrome (pSS), according to the new ACR-EULAR classification criteria, from the UK Primary Sjögren's Syndrome Registry (UKPSSR). METHODS: A total of 665 patients from the UKPSSR cohort were analysed at their time of inclusion in the registry...
February 14, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29440633/kras-induces-lung-tumorigenesis-through-micrornas-modulation
#10
Lei Shi, Justin Middleton, Young-Jun Jeon, Peter Magee, Dario Veneziano, Alessandro Laganà, Hui-Sun Leong, Sudhakar Sahoo, Matteo Fassan, Richard Booton, Rajesh Shah, Philip A J Crosbie, Michela Garofalo
Oncogenic KRAS induces tumor onset and development by modulating gene expression via different molecular mechanisms. MicroRNAs (miRNAs) are small non-coding RNAs that have been established as main players in tumorigenesis. By overexpressing wild type or mutant KRAS (KRAS G12D ) and using inducible human and mouse cell lines, we analyzed KRAS-regulated microRNAs in non-small-cell lung cancer (NSCLC). We show that miR-30c and miR-21 are significantly upregulated by both KRAS isoforms and induce drug resistance and enhance cell migration/invasion via inhibiting crucial tumor suppressor genes, such as NF1, RASA1, BID, and RASSF8...
February 13, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29438631/plasma-endocannabinoid-levels-in-lean-overweight-and-obese-humans-relationships-with-intestinal-permeability-markers-inflammation-and-incretin-secretion
#11
Tanya J Little, Nada Cvijanovic, Nicholas V DiPatrizio, Donovan A Argueta, Christopher K Rayner, Christine Feinle-Bisset, Richard L Young
INTRODUCTION/AIMS: Intestinal production of endocannabinoid and oleoylethanolamide (OEA) is impaired in high-fat diet/obese rodents, leading to reduced satiety. Such diets also alter the intestinal microbiome in association with enhanced intestinal permeability and inflammation, however little is known of these effects in humans. This study aimed to: (i) evaluate effects of lipid on plasma anandamide (AEA), 2-arachidonyl-sn-glycerol (2-AG) and OEA in humans, and (ii) examine relationships with intestinal permeability, inflammation markers and incretin hormone secretion...
February 13, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29438601/open-access-is-there-a-predator-at-the-door
#12
EDITORIAL
Rakesh Chandra, Edward W Fisher, Terry M Jones, David W Kennedy, Dennis H Kraus, John H Krouse, Michael Link, Lawrence R Lustig, Bert W O'Malley, Jay F Piccirillo, Robert Ruben, Robert T Sataloff, Sandra Schwartz, Raj Sindwani, Richard J Smith, Michael G Stewart, Peter C Weber, D Bradley Welling, Robin Youngs
No abstract text is available yet for this article.
February 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29436883/academic-and-non-academic-predictors-of-student-psychological-distress-the-role-of-social-identity-and-loneliness
#13
Jason C McIntyre, Joanne Worsley, Rhiannon Corcoran, Paula Harrison Woods, Richard P Bentall
BACKGROUND: University students experience high rates of stress and mental illness; however, few studies have comprehensively examined the impact of academic and non-academic stressors on student mental health. Similarly, there has been little focus on the role of social groups in protecting against mental distress in this young adult group. AIM: To identify the key social determinants of mental health symptoms in a student population. METHODS: Using an online survey, we administered measures of social connectedness and mental health symptoms alongside academic and non-academic stressors to a large sample of UK university students...
February 13, 2018: Journal of Mental Health
https://www.readbyqxmd.com/read/29433971/large-scale-sequencing-of-testicular-germ-cell-tumour-tgct-cases-excludes-major-tgct-predisposition-gene
#14
Kevin Litchfield, Chey Loveday, Max Levy, Darshna Dudakia, Elizabeth Rapley, Jeremie Nsengimana, D Tim Bishop, Alison Reid, Robert Huddart, Peter Broderick, Richard S Houlston, Clare Turnbull
Testicular germ cell tumour (TGCT), the most common cancer in young men, has a significant heritable basis that has long raised questions as to the existence of underlying major high-penetrance susceptibility gene(s). To determine the contribution of rare gene mutations to the inherited risk of TGCT, we analysed germline whole-exome data for 919 TGCT cases and 1609 cancer-free controls. We compared frequencies between TGCT cases and controls of rare (<1%) and low-frequency (1-5%) coding variants (1) individually and (2) collapsed at the gene level via burden testing (T1, disruptive; T2, all deleterious; and T3, all nonsynonymous) using Fisher's exact test with Bonferroni correction of significance thresholds...
February 9, 2018: European Urology
https://www.readbyqxmd.com/read/29433689/open-access-is-there-a-predator-at-the-door
#15
EDITORIAL
Rakesh Chandra, Edward W Fisher, Terry M Jones, David W Kennedy, Dennis H Kraus, John H Krouse, Michael Link, Lawrence R Lustig, Bert W O'Malley, Jay F Piccirillo, Robert Ruben, Robert T Sataloff, Sandra Schwartz, Raj Sindwani, Richard J Smith, Michael G Stewart, Peter C Weber, D Bradley Welling, Robin Youngs
No abstract text is available yet for this article.
January 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29432623/a-time-motion-study-of-primary-care-physicians-work-in-the-electronic-health-record-era
#16
Richard A Young, Sandra K Burge, Kaparaboyna A Kumar, Jocelyn M Wilson, Daniela F Ortiz
BACKGROUND AND OBJECTIVES: Electronic health records (EHRs) have had mixed effects on the workflow of ambulatory primary care. In this study, we update previous research on the time required to care for patients in primary care clinics with EHRs. METHODS: We directly observed family physician (FP) attendings, residents, and their ambulatory patients in 982 visits in clinics affiliated with 10 residencies of the Residency Research Network of Texas. The FPs were purposely chosen to reflect a diversity of patient care styles...
February 2018: Family Medicine
https://www.readbyqxmd.com/read/29427317/overexpression-of-pgc-1%C3%AE-in-aging-muscle-enhances-a-subset-of-young-like-molecular-patterns
#17
Sofia Garcia, Nadee Nissanka, Edson A Mareco, Susana Rossi, Susana Peralta, Francisca Diaz, Richard L Rotundo, Robson F Carvalho, Carlos T Moraes
PGC-1α is a transcriptional co-activator known as the master regulator of mitochondrial biogenesis. Its control of metabolism has been suggested to exert critical influence in the aging process. We have aged mice overexpressing PGC-1α in skeletal muscle to determine whether the transcriptional changes reflected a pattern of expression observed in younger muscle. Analyses of muscle proteins showed that Pax7 and several autophagy markers were increased. In general, the steady-state levels of several muscle proteins resembled that of muscle from young mice...
February 10, 2018: Aging Cell
https://www.readbyqxmd.com/read/29426618/thyroid-lobectomy-is-not-sufficient-for-t2-papillary-thyroid-cancers
#18
Samer R Rajjoub, Huan Yan, Natalie A Calcatera, Kristine Kuchta, Chi-Hsiung E Wang, Waseem Lutfi, Tricia A Moo-Young, David J Winchester, Richard A Prinz
BACKGROUND: Histologic subtypes of papillary thyroid cancer affect prognosis. The objective of this study was to examine whether survival is affected by extent of surgery for conventional versus follicular-variant papillary thyroid cancer when stratified by tumor size. METHODS: Using the National Cancer Data Base, we evaluated 33,816 adults undergoing surgery for papillary thyroid cancer from 2004 to 2008 for 1.0-3.9 cm tumors and clinically negative lymph nodes...
February 7, 2018: Surgery
https://www.readbyqxmd.com/read/29425298/-man-up-the-importance-and-strategy-for-placing-male-reproductive-health-centre-stage-in-the-political-and-research-agenda
#19
Christopher L R Barratt, Christopher J De Jonge, Richard M Sharpe
Approximately 1 in 20 young men today have sperm counts low enough to impair fertility, whereas this may not have been the case historically. The cause(s) of such a decline in male reproductive health is unknown, despite it being a global health issue. Concomitantly, little progress has been made in answering fundamental questions in andrology or in developing new diagnostic tools or alternative management strategies to ICSI in infertile men. We advocate formulation of a detailed roadmap for male reproductive health to facilitate development of a research agenda that highlights the present unmet needs and key unanswered questions, and seeks to deliver effective funding and investment to address them...
February 7, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29424818/open-access-is-there-a-predator-at-the-door
#20
Rakesh Chandra, Edward W Fisher, Terry M Jones, David W Kennedy, Dennis H Kraus, John H Krouse, Michael Link, Lawrence R Lustig, Bert W O'Malley, Jay F Piccirillo, Robert Ruben, Robert T Sataloff, Sandra Schwartz, Raj Sindwani, Richard J Smith, Michael G Stewart, Peter C Weber, D Bradley Welling, Robin Youngs
No abstract text is available yet for this article.
March 2018: Otology & Neurotology
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