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https://www.readbyqxmd.com/read/29166308/an-evaluation-of-the-choice-for-contralateral-prophylactic-mastectomy-and-patient-concerns-about-recurrence-in-a-reconstructed-cohort
#1
Ian C Sando, Jessica I Billig, Shoshana W Ambani, Casey T Kraft, Kelley M Kidwell, Lin Zhong, Kevin C Chung, Adeyiza O Momoh
BACKGROUND: Rising contralateral prophylactic mastectomy rates are a subject of national concern. This study assessed (1) factors critical to patients when deciding on contralateral prophylactic mastectomy and (2) patients' quality of life related to concerns about recurrence after unilateral or bilateral breast reconstruction. METHODS: Patients with stage 0 to III breast cancer who underwent unilateral mastectomy or contralateral prophylactic mastectomy and breast reconstruction at a single institution between 2000 and 2012 were identified...
November 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29166293/applicability-of-the-calcaneal-apophysis-ossification-staging-system-to-the-modern-pediatric-population
#2
Samuel Q Li, Allen D Nicholson, Daniel R Cooperman, Raymond W Liu
BACKGROUND: The calcaneal apophysis ossification staging system is a novel method for assessing skeletal maturity. However, it was created using the same historic patient population that was used to create the Greulich and Pyle atlas of the hand and wrist, predominantly white children. It is unclear if the calcaneal apophysis ossification staging system is still applicable to the modern pediatric population and to children of other races. METHODS: We retrospectively studied 1327 benign lateral foot x-rays from modern white and black children...
November 21, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29164974/clinical-and-molecular-characterization-of-brca-associated-breast-cancer-results-from-the-dbcg
#3
I M H Soenderstrup, A V Laenkholm, M B Jensen, J O Eriksen, A M Gerdes, T V O Hansen, T A Kruse, M J Larsen, I S Pedersen, M Rossing, M Thomassen, B Ejlertsen
BACKGROUND: In breast cancer (BC) patients a cancer predisposing BRCA1/2 mutation is associated with adverse tumor characteristics, risk assessment and treatment allocation. We aimed to estimate overall- (OS) and disease-free survival (DFS) according to tumor characteristics and treatment among women who within two years of definitive surgery for primary BC were shown to carry a mutation in BRCA1/2 . MATERIAL AND METHODS: From the clinical database of the Danish Breast Cancer Group we included 141 BRCA1 and 96 BRCA2 BC patients...
November 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29164568/cystic-hygroma-of-the-neck-single-center-experience-and-literature-review
#4
C Damaskos, N Garmpis, M Manousi, A Garmpi, G-A Margonis, E Spartalis, C Doula, C Michail-Strantzia, N Patelis, D Schizas, P-T Arkoumanis, N Andreatos, G Tsourouflis, N Zavras, K Markatos, K Kontzoglou, E A Antoniou
OBJECTIVE: Malformations of the lymphatic system are recognized as benign congenital tumors that affect infant and children in the perinatal era. In children, these abnormalities usually found in the neck and the axillary region, but they can present in other parts of the body such as mediastinum, pelvis, retroperitoneum as well as in solid organs (e.g., adrenal glands, pancreas, stomach). Our aim is to report our experience on cystic hygromas via two cases and review the literature. MATERIALS AND METHODS: Herein we present two cases of cystic hygroma, the first of female children and the second of a female adult patient respectively...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164448/measuring-nutrition-literacy-in-spanish-speaking-latinos-an-exploratory-validation-study
#5
Heather D Gibbs, Juliana M T B Camargo, Sarah Owens, Byron Gajewski, Ana Paula Cupertino
Nutrition is important for preventing and treating chronic diseases highly prevalent among Latinos, yet no tool exists for measuring nutrition literacy among Spanish speakers. This study aimed to adapt the validated Nutrition Literacy Assessment Instrument for Spanish-speaking Latinos. This study was developed in two phases: adaptation and validity testing. Adaptation included translation, expert item content review, and interviews with Spanish speakers. For validity testing, 51 participants completed the Short Assessment of Health Literacy-Spanish (SAHL-S), the Nutrition Literacy Assessment Instrument in Spanish (NLit-S), and socio-demographic questionnaire...
November 21, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29164297/dose-and-schedule-modification-are-required-for-long-term-continuation-of-sunitinib-in-japanese-patients-with-advanced-pancreatic-neuroendocrine-tumors
#6
Lingaku Lee, Tetsuhide Ito, Hisato Igarashi, Masami Miki, Nao Fujimori, Ken Kawabe, Robert T Jensen, Yoshihiro Ogawa
PURPOSE: This study aimed to clarify the efficacy and safety of sunitinib in Japanese patients with pancreatic neuroendocrine tumors (PNET), especially by focusing on dose and schedule modification. METHODS: Sixteen patients with advanced PNET treated with sunitinib were reviewed retrospectively. Efficacy was evaluated by progression-free survival (PFS) and objective tumor response. Toxicity profile was assessed regularly. Correlation between relative dose intensity (RDI) and treatment period was also evaluated...
November 21, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29164164/female-sex-is-a-risk-factor-for-failure-of-hip-arthroscopy-performed-for-acetabular-retroversion
#7
Kirsten L Poehling-Monaghan, Aaron J Krych, Bruce A Levy, Robert T Trousdale, Rafael J Sierra
Background: The success of hip surgery in treating acetabular retroversion depends on the severity of the structural deformity and on selecting the correct patient for open or arthroscopic procedures. Purpose: To compare a group of patients with retroverted hips treated successfully with hip arthroscopy with a group of patients with retroverted hips that failed arthroscopic surgery, with special emphasis on (1) patient characteristics, (2) perioperative radiographic parameters, (3) intraoperative findings and concomitant procedures, and (4) patient sex...
November 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29164142/pathogenesis-molecular-genetics-and-genomics-of-mycobacterium-avium-subsp-paratuberculosis-the-etiologic-agent-of-johne-s-disease
#8
REVIEW
Govardhan Rathnaiah, Denise K Zinniel, John P Bannantine, Judith R Stabel, Yrjö T Gröhn, Michael T Collins, Raúl G Barletta
Mycobacterium avium subsp. paratuberculosis (MAP) is the etiologic agent of Johne's disease in ruminants causing chronic diarrhea, malnutrition, and muscular wasting. Neonates and young animals are infected primarily by the fecal-oral route. MAP attaches to, translocates via the intestinal mucosa, and is phagocytosed by macrophages. The ensuing host cellular immune response leads to granulomatous enteritis characterized by a thick and corrugated intestinal wall. We review various tissue culture systems, ileal loops, and mice, goats, and cattle used to study MAP pathogenesis...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29163939/infection-prevention-and-control-measures-and-tools-for-the-prevention-of-entry-of-carbapenem-resistant-enterobacteriaceae-into-healthcare-settings-guidance-from-the-european-centre-for-disease-prevention-and-control
#9
A P Magiorakos, K Burns, J Rodríguez Baño, M Borg, G Daikos, U Dumpis, J C Lucet, M L Moro, E Tacconelli, G Skov Simonsen, E Szilágyi, A Voss, J T Weber
Background: Infections with carbapenem-resistant Enterobacteriaceae (CRE) are increasingly being reported from patients in healthcare settings. They are associated with high patient morbidity, attributable mortality and hospital costs. Patients who are "at-risk" may be carriers of these multidrug-resistant Enterobacteriaceae (MDR-E).The purpose of this guidance is to raise awareness and identify the "at-risk" patient when admitted to a healthcare setting and to outline effective infection prevention and control measures to halt the entry and spread of CRE...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29163472/the-kynurenine-pathway-as-a-novel-link-between-allergy-and-the-gut-microbiome
#10
REVIEW
Aaron P Van der Leek, Yarden Yanishevsky, Anita L Kozyrskyj
In the past few decades, the indoleamine 2,3 dioxygenase (IDO) subset of the kynurenine (KYN) pathway of tryptophan (TRP) metabolism has been the subject of much research in the area of immune tolerance. In this review, we aim to incorporate new findings on this pathway in relation to allergy and the gut microbiome, while providing a comprehensive overview of the pathway itself. Stimulated by interferon gamma, IDO acts as a tolerogenic, immunosuppressive enzyme to attenuate allergic responses by the induction of the KYN-IDO pathway, resultant depletion of TRP, and elevation in KYN metabolites...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29162028/endovascular-renal-artery-stent-retriever-embolectomy-in-a-young-patient-with-cardiac-myxoma-case-report-and-review-of-the-literature
#11
Michael A Silva, Alfred P See, Samir K Shah, Priyank Khandelwal, Nirav J Patel, Heather Lyu, Matthew T Menard, Mohammad Ali Aziz-Sultan
PURPOSE: Cardiac myxomas are common tumors of the heart with disproportionate impact on young patients, occasionally with dramatic systemic dissemination of tumor emboli with catastrophic multiorgan system ischemia. The coincident comorbidities can increase the risk of traditional treatments for tumor embolus in each region. CASE REPORT: A young patient with previously unknown cardiac myxoma presented with seizure and was found to have stress cardiomyopathy, multiple cerebral large vessel occlusions with acute ischemic stroke, bilateral lower extremity tumor emboli and rhabdomyolysis, and renal tumor embolus with acute tubular necrosis...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29161336/efficacy-of-electrical-stimulation-of-the-occipital-nerve-in-intractable-primary-headache-disorders-a-systematic-review-with-meta-analyses
#12
Robert T Cadalso, John Daugherty, Caron Holmes, Saravanan Ram, Reyes Enciso
AIMS: To determine the efficacy of occipital nerve stimulation (ONS) in reducing the intensity, duration, and frequency of medically intractable primary headaches. METHODS: A systematic review was carried out by searching three electronic databases: the Cochrane Library, MEDLINE via PubMed, and Web of Science. Randomized controlled trials (RCTs) and case series were eligible for inclusion. RCTs were assessed for quality of evidence by using the Cochrane Risk of Bias and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tools...
November 21, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29160785/scleral-pits-in-choroideremia-implications-for-retinal-gene-therapy
#13
Abdullah A Al-Qahtani, Shakoor Ba-Ali, Talal Alabduljalil, Aaron S Coyner, Rachel C Patel, Richard G Weleber, Aniz Girach, Søren K Christensen, Michael Larsen, Mark E Pennesi, Paul Yang
PURPOSE: We report a novel finding on spectral domain optical coherence tomography in patients with choroideremia, which we describe as scleral pits (SCPs). METHODS: Cross-sectional observational case series of 36 patients with choroideremia, who underwent ophthalmic examination and multimodal imaging, including optical coherence tomography of the macula. Optical coherence tomography images were reviewed for SCP, which were defined as discrete tracts of hyporeflectivity that traverse the sclera with or without the involvement of Bruch membrane, retinal pigment epithelium, and retina...
November 16, 2017: Retina
https://www.readbyqxmd.com/read/29160395/tooth-loss-in-patients-under-periodontal-maintenance-in-a-private-practice-a-retrospective-study
#14
Amanda Finger Stadler, Marina Mendez, Rui Vicente Oppermann, Sabrina Carvalho Gomes
The aim of the present study was to evaluate the incidence and causes of tooth loss in periodontal subjects from a private practice in Brazil. Two trained examiners extracted data from the records of subjects who sought periodontal treatment from 1980 to 2013. Only records of patients who completed the non-surgical periodontal treatment and had at least one visit for maintenance were included. Data were analyzed by chi-square test, Student's t-test, Kaplan-Meier survival curve and Cox regression. A total of 3,319 records were reviewed and 737 records included (58...
July 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29159766/incidence-of-immune-related-adverse-events-and-its-association-with-treatment-outcomes-the-md-anderson-cancer-center-experience
#15
Takeo Fujii, Rivka R Colen, Mehmet Asim Bilen, Kenneth R Hess, Joud Hajjar, Maria E Suarez-Almazor, Anas Alshawa, David S Hong, Apostolia Tsimberidou, Filip Janku, Jing Gong, Bettzy Stephen, Vivek Subbiah, Sarina A Piha-Paul, Siqing Fu, Padmanee Sharma, Tito Mendoza, Anisha Patel, Selvi Thirumurthi, Ajay Sheshadri, Funda Meric-Bernstam, Aung Naing
Background Immunotherapy is emerging as the cornerstone for treatment of patients with advanced cancer, but significant toxicity (immune-related adverse events [irAEs]) associated with unbridled T cell activity remains a concern. Patients and methods A retrospective review of the electronic medical records of 290 patients with advanced cancer treated on an immunotherapy-based clinical trial in the Department of Investigational Cancer Therapeutics at The University of Texas MD Anderson Cancer Center between February 2010 and September 2015 was performed...
November 21, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29159533/reduced-bone-mineral-density-in-human-immunodeficiency-virus-infected-individuals-a-meta-analysis-of-its-prevalence-and-risk-factors
#16
S S L Goh, P S M Lai, A T B Tan, S Ponnampalavanar
A meta-analysis was conducted to evaluate the prevalence of osteopenia/osteoporosis in human immunodeficiency virus (HIV)-infected individuals. The prevalence of osteopenia/osteoporosis in HIV-infected and antiretroviral therapy (ART)-treated individuals was significantly higher than respective controls. Evidence regarding bone loss within first year of HIV infection or ART initiation was preliminary. PURPOSE: The aim of the study is to systematically review published literature on the prevalence of osteopenia/osteoporosis and its associated risk factors in HIV-infected individuals...
November 20, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29158710/the-impact-of-pharmacists-providing-direct-patient-care-as-members-of-interprofessional-teams-on-diabetes-management
#17
Osamah M Alfayez, Majed S Al Yami, Maryam T Fazel
The purpose of this study was to evaluate the impact of pharmacist providing direct patient care as a member of interprofessional team on diabetes management. This study is a retrospective chart review of diabetes patients seen by a pharmacist in an endocrinology clinic affiliated with an academic medical center. The following patient outcomes were recorded pre and post the pharmacist intervention: glycemic control as measured by change in hemoglobin A1c (HbA1c), change in systolic blood pressure (SBP) and diastolic blood pressure (DBP), statin use, and use of angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs)...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29158191/association-between-coffee-intake-after-diagnosis-of-colorectal-cancer-and-reduced-mortality
#18
Yang Hu, Ming Ding, Chen Yuan, Kana Wu, Stephanie A Smith-Warner, Frank B Hu, Andrew T Chan, Jeffrey A Meyerhardt, Shuji Ogino, Charles S Fuchs, Edward L Giovannucci, Mingyang Song
BACKGROUND & AIMS: Few studies have examined the association between coffee intake and survival after diagnosis of colorectal cancer (CRC). We performed a prospective study to investigate the association between coffee intake after a diagnosis of CRC and mortality. METHODS: We collected data from the Nurses' Health Study (1984-2012) and Health Professionals Follow-up Study (1986-2012), following 1599 patients diagnosed with stage 1 or 2 CRC. CRC was reported on questionnaires and ascertained by review of medical records and pathology reports; intake of food and beverages was determined from responses to semi-quantitative food frequency questionnaires...
November 17, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29157759/effect-of-preoperative-education-on-postoperative-outcomes-among-patients-undergoing-cardiac-surgery-a-systematic-review-and-meta-analysis
#19
C Ramesh, Baby S Nayak, Vasudev Baburaya Pai, Nitin T Patil, Anice George, Linu Sara George, Elsa Sanatombi Devi
PURPOSE: The objective of this review was to assess the effect of preoperative education on postoperative outcomes among patients undergoing cardiac surgery. DESIGN: Systematic review and meta-analysis. METHODS: A comprehensive literature search was made on PubMed, CINAHL, Ovid, ProQuest, ScienceDirect, Scopus, Web of Science, and the Cochrane database between 1995 and 2015. Fourteen randomized controlled trials were included. Data analysis was performed with RevMan software and created the Supplementary Appendix using the GRADE approach...
December 2017: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/29157039/comparison-of-cesarean-versus-vaginal-delivery-of-extremely-preterm-gestations-in-breech-presentation-retrospective-cohort-study
#20
Kirsten M Niles, Jon F R Barrett, Noor Niyar N Ladhani
OBJECTIVE: As survival increases at earlier gestational ages, the optimal mode of delivery, especially in cases of breech presentation, is of increasing importance. The objective of this study was to compare outcomes of vaginal delivery (VD) and cesarean section (CS) births for infants in breech presentation at borderline viability. STUDY DESIGN: A retrospective chart review of live breech births between 23 + 0 and 25 + 6 weeks gestation at a tertiary university center from 2003 to 2013 was conducted...
November 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
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