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https://www.readbyqxmd.com/read/29779184/limbic-system-structure-volumes-and-associated-neurocognitive-functioning-in-former-nfl-players
#1
Christian Lepage, Marc Muehlmann, Yorghos Tripodis, Jakob Hufschmidt, Julie Stamm, Katie Green, Pawel Wrobel, Vivian Schultz, Isabelle Weir, Michael L Alosco, Christine M Baugh, Nathan G Fritts, Brett M Martin, Christine Chaisson, Michael J Coleman, Alexander P Lin, Ofer Pasternak, Nikos Makris, Robert A Stern, Martha E Shenton, Inga K Koerte
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts. CTE has been linked to disruptions in cognition, mood, and behavior. Unfortunately, the diagnosis of CTE can only be made post-mortem. Neuropathological evidence suggests limbic structures may provide an opportunity to characterize CTE in the living. Using 3 T magnetic resonance imaging, we compared select limbic brain regional volumes - the amygdala, hippocampus, and cingulate gyrus - between symptomatic former National Football League (NFL) players (n = 86) and controls (n = 22)...
May 19, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29740341/circulating-mirnas-as-putative-biomarkers-of-exercise-adaptation-in-endurance-horses
#2
Katia Cappelli, Stefano Capomaccio, Andrea Viglino, Maurizio Silvestrelli, Francesca Beccati, Livia Moscati, Elisabetta Chiaradia
Endurance exercise induces metabolic adaptations and has recently been reported associated with the modulation of a particular class of small noncoding RNAs, microRNAs, that act as post-transcriptional regulators of gene expression. Released into body fluids, they termed circulating miRNAs, and they have been recognized as more effective and accurate biomarkers than classical serum markers. This study examined serum profile of miRNAs through massive parallel sequencing in response to prolonged endurance exercise in samples obtained from four competitive Arabian horses before and 2 h after the end of competition...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29706930/a-preliminary-report-on-brain-derived-extracellular-vesicle-as-novel-blood-biomarkers-for-sport-related-concussions
#3
Keisuke Kawata, Masato Mitsuhashi, Randy Aldret
The purpose of the study was to test the utility of unique panel of blood biomarkers as a means to reflect one's recovery process after sport-related neurotrauma. We established a panel of biomarkers that reacted positive with CD81 (extracellular vesicle marker) and various neuron- and glia-specific antigens [e.g., neurofilament light polypeptide (NF-L), tau, synaptosome-associated protein 25 (SNAP25), glial fibrillary acidic protein, and myelin basic protein]. We first evaluated test-retest reliabilities of brain-derived exosome markers, followed by an application of these markers in eight professional ice hockey players to detect cumulative neuronal burden from a single ice hockey season...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29685283/blood-biomarkers-are-associated-with-brain-function-and-blood-flow-following-sport-concussion
#4
Alex P Di Battista, Nathan Churchill, Tom A Schweizer, Shawn G Rhind, Doug Richards, Andrew J Baker, Michael G Hutchison
BACKGROUND: Secondary injury pathophysiology after sport-related concussion (SRC) is poorly understood. Blood biomarkers may be a useful tool for characterizing these processes, yet there are limitations in their application as a single modality. Combining blood biomarker analysis with advanced neuroimaging may help validate their continued utility in brain injury research by elucidating important secondary injury mechanisms. Hence, the purpose of this study was to evaluate co-modulation between peripheral blood biomarkers and advanced functional brain imaging after SRC...
June 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29682219/cardiovascular-disease-related-mirnas-expression-potential-role-as-biomarkers-and-effects-of-training-exercise
#5
REVIEW
Simona Ultimo, Giorgio Zauli, Alberto M Martelli, Marco Vitale, James A McCubrey, Silvano Capitani, Luca M Neri
Cardiovascular diseases (CVDs) are one of the most important causes of mortality worldwide, therefore the need of effective preventive strategies is imperative. Aging is associated with significant changes in both cardiovascular structure and function that lower the threshold for clinical signs and symptoms, making older people more susceptible to CVDs morbidity and mortality. microRNAs (miRNAs) modulate gene expression at post-transcriptional level and increasing evidence has shown that miRNAs are involved in cardiovascular physiology and in the pathogenesis of CVDs...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29666559/assessing-performance-in-pre-season-wrestling-athletes-using-biomarkers
#6
Ionas Papassotiriou, Artemissia-Phoebe Nifli
Introduction: Although regular training introduces the desired changes in athletes' metabolism towards optimal final performance, literature is rarely focusing on the metabolic responses off-competition. Therefore, the aim of this study was to evaluate biochemical indices during typical preseason training in wrestling athletes. Materials and methods: Twenty male freestyle and Greco-roman wrestlers (14 to 31 years) followed a typical session of the preparatory phase...
June 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/29621963/detecting-autologous-blood-transfusion-in-doping-control-biomarkers-of-blood-aging-and-storage-measured-by-flow-cytofluorimetry
#7
Francesco Botre, Roberta Acciarini, Ilenia De Benedittis, Xavier de la Torre, Daniela Pirri, Mariangela Prete, Alessandra Stampella, Enza Vernucci
Backgorund: Blood transfusions are banned by the World Anti-Doping Agency as a form of "blood doping". A method of detection of homologous blood transfusion (HBT) has been implemented by the accredited anti-doping laboratories worldwide; however, no internationally recognized method has been finalized so far for the direct detection of autologous blood transfusions, which can at present be revealed only by targeted longitudinal profiling of key blood parameters. METHODS: The present article reports the results of an investigation aimed to pre-select potential biomarkers of blood aging and storage that can be measured to identify the presence in the sample of re-infused blood...
April 5, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29617642/the-science-and-translation-of-lactate-shuttle-theory
#8
REVIEW
George A Brooks
Once thought to be a waste product of anaerobic metabolism, lactate is now known to form continuously under aerobic conditions. Shuttling between producer and consumer cells fulfills at least three purposes for lactate: (1) a major energy source, (2) the major gluconeogenic precursor, and (3) a signaling molecule. "Lactate shuttle" (LS) concepts describe the roles of lactate in delivery of oxidative and gluconeogenic substrates as well as in cell signaling. In medicine, it has long been recognized that the elevation of blood lactate correlates with illness or injury severity...
April 3, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29589779/telomere-length-is-independently-associated-with-age-oxidative-biomarkers-and-sport-training-in-skeletal-muscle-of-healthy-adult-males
#9
Fiorenza Magi, Ivan Dimauro, Fabrizio Margheritini, Guglielmo Duranti, Neri Mercatelli, Cristina Fantini, Francesca Romana Ripani, Stefania Sabatini, Daniela Caporossi
In skeletal muscle, which mainly contains postmitotic myonuclei, it has been suggested that telomere length remains roughly constant throughout adult life, or shortens in response to physiopathological conditions in muscle diseases or in the elderly. However, telomere length results from both the replicative history of a specific tissue and the exposure to environmental, DNA damage-related factors, therefore the predictive biological significance of telomere measures should combine the analysis of the various interactive factors...
March 28, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29572786/changes-in-hemoglobin-profile-reflect-autologous-blood-transfusion-misuse-in-sports
#10
Nicola Lamberti, Alessia Finotti, Jessica Gasparello, Ilaria Lampronti, Christel Zambon, Lucia Carmela Cosenza, Enrica Fabbri, Nicoletta Bianchi, Francesca Dalla Corte, Maurizio Govoni, Roberto Reverberi, Roberto Gambari, Fabio Manfredini
The changes in hemoglobin (Hb) profile following autologous blood transfusion (ABT) for the first time were studied for anti-doping purposes. Twenty-four healthy, trained male subjects (aged 18‒40) were enrolled and randomized into either the transfusion (T) or control (C) groups. Blood samples were taken from the T subjects at baseline, after withdrawal and reinfusion of 450 ml of refrigerated or cryopreserved blood, and from C subjects at the same time points. Hematological variables (Complete blood count, Reticulocytes, Immature Reticulocytes Fraction, Red-cell Distribution Width, OFF-hr score) were measured...
March 23, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29521064/the-effect-of-high-intensity-physical-exercise-and-hypoxia-on-glycemia-angiogenic-biomarkers-and-cardiorespiratory-function-in-patients-with-type-1-diabetes
#11
Aleksandra Żebrowska, Barbara Hall, Aleksandra Kochańska-Dziurowicz, Grażyna Janikowska
BACKGROUND: An integral part of the treatment of diabetes is physical activity. Scientific reports have shown the beneficial effects of hypoxia and exercise on cardiovascular and metabolic variables in patients with diabetes. OBJECTIVES: The aim of the study was to assess the effect of normobaric hypoxia and exercise on the serum concentrations of proangiogenic factors and glycemia in patients with type 1 diabetes. MATERIAL AND METHODS: A total of 28 adults (aged 30...
February 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29486610/a-multicenter-double-blind-phase-iii-clinical-trial-to-evaluate-the-efficacy-and-safety-of-a-cell-and-gene-therapy-in-knee-osteoarthritis-patients
#12
Myung-Ku Kim, Chul-Won Ha, Yong In, Sung-Do Cho, Eui-Sung Choi, Jeong-Ku Ha, Ju-Hong Lee, Jae-Doo Yoo, Seong-Il Bin, Choong-Hyeok Choi, Hee-Soo Kyung, Myung-Chul Lee
OBJECTIVE: To test the clinical efficacy of TissueGene-C (TG-C), a cell and gene therapeutic for osteoarthritis consisting of non-transformed and transduced chondrocytes (3:1), retrovirally transduced to overexpress TGF-β1. DESIGN: We randomly assigned 163 with knee osteoarthritis to receive intra-articular TG-C or placebo in Kellgren-Lawrence grade 3 patients for clinical trial. Primary efficacy measures included criteria for subjective assessment by International Knee Documentation Committee (IKDC) and pain severity by Visual Analog Scale (VAS) for 52 weeks...
February 27, 2018: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/29450135/development-of-a-specific-index-to-detect-malnutrition-in-athletes-validity-in-weight-class-or-intermittent-fasted-athletes
#13
François D Desgorces, Christophe Moinard, Mounir Chennaoui, Jean-François Toussaint, Cyril Petibois, Philippe Noirez
Fasted or weight-category athletes manage their training under strict diet conditions that could impair the stress-recovery balance and result in acute or chronic fatigue. However, to date, no validated biomarker are available to quantify this phenomena. The aim of this study was to assess the validity of a specific index combining plasma albumin and weight change to detect nutrition-related risks of fatigue increase and under-performance in athletes experiencing particular nutritional conditions. An athlete's nutrition risk index (ANRI) equation, based on data from lightweight and heavyweight rowers, was developed using relationship between plasma albumin concentrations combined to weight changes with sport performance and overtraining scores and was tested by odds ratio for failure...
June 2017: Biochimie open
https://www.readbyqxmd.com/read/29420083/an-investigation-of-neuroinjury-biomarkers-after-sport-related-concussion-from-the-subacute-phase-to-clinical-recovery
#14
Alex P Di Battista, Shawn G Rhind, Andrew J Baker, Rakesh Jetly, Jeff D Debad, Doug Richards, Michael G Hutchison
OBJECTIVES: To characterise a panel of neuroinjury-related blood biomarkers after sport-related concussion (SRC). We hypothesised significant differences in biomarker profiles between athletes with SRC and healthy controls at both subacute and medical clearance time points. METHODS: Thirty-eight interuniversity athletes were recruited over two athletic seasons (n = 19 SRC; n = 19 healthy matched-control). High-sensitivity immunoassay was used to evaluate 11 blood analytes at both the subacute phase after SRC and at medical clearance...
2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29416525/patient-specific-alterations-in-co-2-cerebrovascular-responsiveness-in-acute-and-sub-acute-sports-related-concussion
#15
W Alan C Mutch, Michael J Ellis, Lawrence N Ryner, Patrick J McDonald, Marc P Morissette, Philip Pries, Marco Essig, David J Mikulis, James Duffin, Joseph A Fisher
Background: Preliminary studies suggest that sports-related concussion (SRC) is associated with alterations in cerebral blood flow (CBF) regulation. Here, we use advanced magnetic resonance imaging (MRI) techniques to measure CBF and cerebrovascular responsiveness (CVR) in individual SRC patients and healthy control subjects. Methods: 15 SRC patients (mean age = 16.3, range 14-20 years) and 27 healthy control subjects (mean age = 17.6, range 13-21 years) underwent anatomical MRI, pseudo-continuous arterial spin labeling (pCASL) MRI and model-based prospective end-tidal targeting (MPET) of CO2 during blood oxygenation level-dependent (BOLD) MRI...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29411251/the-impact-of-a-cultural-lifestyle-intervention-on-metabolic-parameters-after-gestational-diabetes-mellitus-a-randomized-controlled-trial
#16
Dana Zilberman-Kravits, Naomi Meyerstein, Yones Abu-Rabia, Arnon Wiznitzer, Ilana Harman-Boehm
OBJECTIVES: The prevalence of type 2 diabetes in Israel is increasing in all ethnic groups but most markedly in the Bedouin population. We aimed to assess the effects of a lifestyle change intervention on risk markers for type 2 diabetes after gestational diabetes mellitus (GDM). METHODS: One hundred eighty Jewish and Bedouin post-GDM women were randomly assigned to a lifestyle intervention group (IG) or a control group (CG) starting 3-4 months after delivery. The IG participated in healthy lifestyle sessions led by a dietician and a sports instructor for 24 months after delivery...
June 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29370268/circulating-cell-free-dna-as-a-marker-for-exercise-load-in-intermittent-sports
#17
Nils Haller, Susanne Helmig, Pascal Taenny, Julian Petry, Sebastian Schmidt, Perikles Simon
BACKGROUND: Attempts to establish a biomarker reflecting individual player load in intermittent sports such as football have failed so far. Increases in circulating DNA (cfDNA) have been demonstrated in various endurance sports settings. While it has been proposed that cfDNA could be a suitable marker for player load in intermittent sports, the effects on cfDNA of repeated sprinting as an essential feature in intermittent sports are unknown. For the first time, we assessed both alterations of cfDNA due to repeated maximal sprints and due to a professional football game...
2018: PloS One
https://www.readbyqxmd.com/read/29359646/the-role-of-coach-athlete-relationship-quality-in-team-sport-athletes-psychophysiological-exhaustion-implications-for-physical-and-cognitive-performance
#18
Louise Davis, Ralph Appleby, Paul Davis, Mark Wetherell, Henrik Gustafsson
The present study aimed to examine associations between the quality of the coach-athlete relationship and athlete exhaustion by assessing physiological and cognitive consequences. Male and female athletes (N = 82) representing seven teams across four different sports, participated in a quasi-experimental study measuring physical performance on a 5-meter multiple shuttle test, followed by a Stroop test to assess cognitive performance. Participants provided saliva samples measuring cortisol as a biomarker of acute stress response and completed questionnaires measuring exhaustion, and coach-athlete relationship quality...
January 23, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29322301/effects-of-short-term-dhea-intake-on-hormonal-responses-in-young-recreationally-trained-athletes-modulation-by-gender
#19
Katia Collomp, Corinne Buisson, Nicolas Gravisse, Soraya Belgherbi, Zakaria Labsy, Manh-Cuong Do, Olivier Gagey, Sophie Dufay, Nancy Vibarel-Rebot, Michel Audran
BACKGROUND: Dehydroepiandrosterone (DHEA) figures on the World Anti-Doping Agency list of prohibited substances in sport because it is assumed that athletes expect a significant increase in testosterone through DHEA administration. The literature on the hormonal effects of DHEA intake nevertheless appears to be very scant in healthy young subjects, especially women. PURPOSE: We examined the effects of DHEA on adrenal and gonadal hormones, IGF1 and free T3 in healthy young male and female recreationally trained volunteers...
March 2018: Endocrine
https://www.readbyqxmd.com/read/29305667/a-pilot-study-comparing-the-metabolic-profiles-of-elite-level-athletes-from-different-sporting-disciplines
#20
Fatima Al-Khelaifi, Ilhame Diboun, Francesco Donati, Francesco Botrè, Mohammed Alsayrafi, Costas Georgakopoulos, Karsten Suhre, Noha A Yousri, Mohamed A Elrayess
BACKGROUND: The outstanding performance of an elite athlete might be associated with changes in their blood metabolic profile. The aims of this study were to compare the blood metabolic profiles between moderate- and high-power and endurance elite athletes and to identify the potential metabolic pathways underlying these differences. METHODS: Metabolic profiling of serum samples from 191 elite athletes from different sports disciplines (121 high- and 70 moderate-endurance athletes, including 44 high- and 144 moderate-power athletes), who participated in national or international sports events and tested negative for doping abuse at anti-doping laboratories, was performed using non-targeted metabolomics-based mass spectroscopy combined with ultrahigh-performance liquid chromatography...
January 5, 2018: Sports Medicine—Open
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