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Biomarker sport

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https://www.readbyqxmd.com/read/28700478/impact-of-nonsteroidal-aromatase-inhibitors-on-steroid-profile-in-a-chinese-population
#1
Yanyi Xing, Xin Liu, Mengmeng Yan, Tianqi Chen, Fei Lu, Bing Xu, Yan Gong, Fuhao Chu, Haimin Lei
Steroid profiling was introduced to determine the endogenous steroid misuse in sports. Thus, screening for the exogenous use of these prohibited substances can be established by monitoring a range of endogenous steroids, which constitute the steroid profile and evaluate their concentrations and ratios against reference values. The steroid profiling is currently based on population statistics. As large interindividual variations exist, athlete biological passport (ABP) analysis is ongoing. This study aimed to identify new biomarker(s) for aromatase inhibitor detection in sports using statistical analysis and adapt the model into ABP analysis...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28699381/prospective-assessment-of-acute-blood-markers-of-brain-injury-in-sport-related-concussion
#2
Timothy Meier, Lindsay D Nelson, Daniel L Huber, Jeff Bazarian, Ronald L Hayes, Michael McCrea
There is a pressing need to identify objective biomarkers for the assessment of sport-related concussion to reduce the reliance on clinical judgment for the management of these injuries. The goal of the current study was to prospectively establish the acute effects of sport-related concussion (SRC) on serum levels of S100B, GFAP, and UCH-L1. Collegiate and high school football players were enrolled and provided blood at preseason. Injured athletes participated in follow-up visits at approximately 6 and 24-48 hours following documented SRC (N=32)...
July 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28673410/blood-based-biomarkers-for-the-identification-of-sports-related-concussion
#3
REVIEW
Martina Anto-Ocrah, Courtney Marie Cora Jones, Danielle Diacovo, Jeffrey J Bazarian
Sports-related concussions (SRCs) are common among athletes in the United States. Most athletes who sustain an SRC recover within 7 to 10 days; however, many athletes who sustain the injury do not recover as expected and experience prolonged, persistent symptoms. In this document, the authors provide an overview of the empirical evidence related to the use of blood-based brain biomarkers in the athlete population for diagnosis of SRCs, prognosis of recovery and return to play guidelines, and indications of neurodegeneration...
August 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/28670860/transcriptomic-biomarkers-of-altered-erythropoiesis-to-detect-autologous-blood-transfusion
#4
Olivier Salamin, Jonathan Mignot, Tiia Kuuranne, Martial Saugy, Nicolas Leuenberger
Autologous blood transfusion is a powerful means to improve performance and remains one of the most challenging method to detect. Recent investigations have identified three candidate reticulocytes genes whose expression was significantly influenced by blood transfusion. Using quantitative reverse transcription polymerase chain reaction as alternative quantitative method, the present study supports that delta-aminolevulinate synthase 2 (ALAS2), carbonic anhydrase (CA1) and solute carrier family 4 member 1 (SLC4A1) genes are down-regulated post-transfusion...
July 3, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28663136/can-salivary-testosterone-and-cortisol-reactivity-to-a-mid-week-stress-test-discriminate-a-match-outcome-during-international-rugby-union-competition
#5
Blair T Crewther, Neil Potts, Liam P Kilduff, Scott Drawer, Christian J Cook
OBJECTIVES: Evidence suggests that stress-induced changes in testosterone and cortisol are related to future competitive behaviours and team-sport outcomes. Therefore, we examined whether salivary testosterone and cortisol reactivity to a mid-week stress test can discriminate a match outcome in international rugby union competition. DESIGN: Single group, quasi-experimental design with repeated measures. METHOD: Thirty-three male rugby players completed a standardised stress test three or four days before seven international matches...
June 2, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28626873/assessing-prefrontal-cortex-oxygenation-after-sport-concussion-with-near-infrared-spectroscopy
#6
Scott A Bishop, J Patrick Neary
BACKGROUND: Clinicians typically rely on neuropsychological and balance tests to track concussion recovery. The aforementioned tests imply impairments that are based on performance, but these tests do not directly measure brain physiology throughout concussion recovery. Because of these issues, an objective biomarker that can index severity and the recovery timeline is needed. Moreover, the number of concussions occurring at a recreational level requires the biomarker to be easily administered in a cost effective manner, and the results easily interpreted...
June 18, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28571016/next-generation-omics-approaches-in-the-fight-against-blood-doping
#7
Guan Wang, Antonia Karanikolou, Ioanna Verdouka, Theodore Friedmann, Yannis Pitsiladis
Despite being prohibited by the World Anti-Doping Agency (WADA), blood manipulations such as the use of recombinant human erythropoietin and blood transfusions are a well-known method used by athletes to enhance performance. Direct detection of illicit blood manipulation has been partially successful due to the short detection window of the substances/methods, sample collection timing, and the use of sophisticated masking strategies. In response, WADA introduced the athlete biological passport (ABP) in 2009, which is an individualised longitudinal monitoring approach that tests primarily haematologic biomarkers of doping in order to identify atypical variability in response(s) in athletes, highlighting a potential doping violation...
2017: Medicine and Sport Science
https://www.readbyqxmd.com/read/28569552/cardiac-troponins-potential-biomarkers-for-the-detection-of-subclinical-coronary-artery-disease-in-athletes-participating-in-endurance-sports
#8
Jinlei Nie
No abstract text is available yet for this article.
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28548390/a-step-towards-removing-plasma-volume-variance-from-the-athlete-s-biological-passport-the-use-of-biomarkers-to-describe-vascular-volumes-from-a-simple-blood-test
#9
Louisa M Lobigs, Pierre-Edouard Sottas, Pitre C Bourdon, Zoran Nikolovski, Mohamed El-Gingo, Evdokia Varamenti, Peter Peeling, Brian Dawson, Yorck O Schumacher
The haematological module of the Athlete's Biological Passport (ABP) has significantly impacted the prevalence of blood manipulations in elite sports. However, the ABP relies on a number of concentration-based markers of erythropoiesis, such as haemoglobin concentration ([Hb]), which are influenced by shifts in plasma volume (PV). Fluctuations in PV contribute to the majority of biological variance associated with volumetric ABP markers. Our laboratory recently identified a panel of common chemistry markers (from a simple blood test) capable of describing ~67% of PV variance, presenting an applicable method to account for volume shifts within antidoping practices...
May 26, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28544811/differential-protein-expression-in-exosomal-samples-taken-from-trauma-patients
#10
Ron B Moyron, Amber Gonda, Matthew J Selleck, Xian Luo-Owen, Richard D Catalano, Thomas O'Callahan, Carlos Garberoglio, David Turay, Nathan R Wall
Traumatic brain injuries (TBI) are among the most misdiagnosed and underreported types of head trauma. The potential long-term impact of undiagnosed or incorrectly identified concussions and other head injuries are potentially devastating, as evidenced by the increasing societal burden exhibited by soldiers returning from combat and athletes in contact sports. Concussions and TBI are notoriously difficult to correctly diagnose and prognosis for these injuries is poorly understood. In order to increase the likelihood of successful diagnosis, treatment, and prediction of outcomes, a definitive differential diagnosis will need to be established...
May 25, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28487812/high-sensitive-c-reactive-protein-levels-in-a-group-of-syrian-university-male-students-and-its-associations-with-smoking-physical-activity-anthropometric-measurements-and-some-hematologic-inflammation-biomarkers
#11
Wafika Zarzour, Nada Dehneh, Mazen Rajab
In Syria, health risk data on young males are limited. Hence, the aim of the present study was to evaluate cardiovascular disease (CVD) risk factors along with C-reactive protein levels measured by high-sensitive method (hsCRP) in a group of healthy males of university students (n = 101, 18-25 years old). Participants' anthropometric characteristics; alcohol drinking, smoking, and physical activity habits; parents medical history; and some inflammatory biomarkers were inspected for their associations with hsCRP...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28474406/analysis-of-rbc-microparticles-in-stored-whole-blood-bags-a-promising-marker-to-detect-blood-doping-in-sports
#12
Sven Christian Voss, Morana Jaganjac, Amna Mohamed Al-Thani, Jean Charles Grivel, Christophe Raynaud, Hind Al-Jaber, Afnan Saleh Al-Menhali, Zeyed Ahmad Merenkov, Mohammed Alsayrafi, Aishah Latiff, Costas Georgakopoulos
Blood doping in sports is prohibited by the World Anti-Doping Agency (WADA). To find a possible biomarker for the detection of blood doping, we investigated the changes in blood stored in CPDA-1 blood bags of eight healthy subjects who donated one unit of blood. Aliquots were taken on days 0, 14 and 35. Platelet free Plasma was prepared and stored at -80 °C until analysis on a flow cytometer dedicated for the analysis of Microparticles (MPs). Changes in the number of Red Blood Cell (RBC) -MPs were highly significant (p < 0...
May 4, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28471203/-ascites-may-provide-useful-information-for-diagnosis-of-ovarian-cancer
#13
E Stuchlíková, M Zahradníková, R Nenutil, D Valík, B Vojtěšek, M Novotný, L Hernychova
BACKGROUND: Ovarian cancer is the most lethal gynecological cancer, almost 80% of all patients succumb the disease within 5 years of diagnosis. High mortality is caused especially by nonspecific symptoms, diagnosis in late stages and the absence of a specific biomarker. Currently, the most common diagnostic biomarkers are the membrane glycoprotein Cancer Antigen 125 (CA 125), the Human Epididymal Protein 4 (HE4) and the Carcinoembryonic Antigen (CAE). None of these biomarkers is specific only for ovarian cancer and increased levels may be caused by other diseases...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28464406/sustained-apnea-induces-endothelial-activation
#14
Lars Eichhorn, Ramona Dolscheid-Pommerich, Felix Erdfelder, Muhammad Ajmal Ayub, Theresa Schmitz, Nikos Werner, Felix Jansen
BACKGROUND: Apnea diving has gained worldwide popularity, even though the pathophysiological consequences of this challenging sport on the human body are poorly investigated and understood. This study aims to assess the influence of sustained apnea in healthy volunteers on circulating microparticles (MPs) and microRNAs (miRs), which are established biomarkers reflecting vascular function. HYPOTHESIS: Short intermittent hypoxia due to voluntary breath-holding affects circulating levels of endothelial cell-derived MPs (EMPs) and endothelial cell-derived miRs...
May 2, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28455364/role-of-advanced-neuroimaging-fluid-biomarkers-and-genetic-testing-in-the-assessment-of-sport-related-concussion-a-systematic-review
#15
REVIEW
Michael McCrea, Timothy Meier, Daniel Huber, Alain Ptito, Erin Bigler, Chantel T Debert, Geoff Manley, David Menon, Jen-Kai Chen, Rachel Wall, Kathryn J Schneider, Thomas McAllister
OBJECTIVE: To conduct a systematic review of published literature on advanced neuroimaging, fluid biomarkers and genetic testing in the assessment of sport-related concussion (SRC). DATA SOURCES: Computerised searches of Medline, PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycINFO, Scopus and Cochrane Library from 1 January 2000 to 31 December 2016 were done. There were 3222 articles identified. STUDY SELECTION: In addition to medical subject heading terms, a study was included if (1) published in English, (2) represented original research, (3) involved human research, (4) pertained to SRC and (5) involved data from neuroimaging, fluid biomarkers or genetic testing collected within 6 months of injury...
June 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28455363/what-is-the-physiological-time-to-recovery-after-concussion-a-systematic-review
#16
REVIEW
Joshua Kamins, Erin Bigler, Tracey Covassin, Luke Henry, Simon Kemp, John J Leddy, Andrew Mayer, Michael McCrea, Mayumi Prins, Kathryn J Schneider, Tamara C Valovich McLeod, Roger Zemek, Christopher C Giza
AIM OR OBJECTIVE: The aim of this study is to consolidate studies of physiological measures following sport-related concussion (SRC) to determine if a time course of postinjury altered neurobiology can be outlined. This biological time course was considered with respect to clinically relevant outcomes such as vulnerability to repeat injury and safe timing of return to physical contact risk. DESIGN: Systematic review. DATA SOURCES: PubMed, CINAHL, Cochrane Central, PsychINFO...
June 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28404801/serum-neurofilament-light-as-a-biomarker-for-mild-traumatic-brain-injury-in-contact-sports
#17
Pashtun Shahim, Henrik Zetterberg, Yelverton Tegner, Kaj Blennow
OBJECTIVE: To evaluate whether the axonal protein neurofilament light (NFL) in serum is a sensitive biomarker to detect subtle brain injury or concussion in contact sports athletes. METHODS: Two prospective cohort studies involving (1) 14 Swedish amateur boxers who underwent fluid biomarker assessments at 7-10 days after bout and after 3 months of rest from boxing and (2) 35 Swedish professional hockey players who underwent blood biomarker assessment at 1, 12, 36, and 144 hours after concussion and when the players returned to play were performed...
May 9, 2017: Neurology
https://www.readbyqxmd.com/read/28390522/research-frontiers-in-traumatic-brain-injury-defining-the-injury
#18
REVIEW
Andrew J Gardner, Shirley L Shih, Elizabeth V Adamov, Ross D Zafonte
With the continued advancement in technology, such as increasingly sophisticated neuroimaging parameters, and the ongoing development of various scientific fields, like serum and blood biomarkers, genetics, and physiology, traumatic brain injury (TBI) research is a dynamic field of study. TBI remains a significant public health concern and research has continued to grow exponentially over the past decade. This review provides an overview of the frontiers of TBI research, from sports concussion to severe TBI, from acute and subacute injury to long-term/chronic outcomes, from assessment and management to prognosis, specifically examining recent neuroimaging, biomarkers, genetics, and physiologic studies...
May 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/28337894/actn3-ace-genotypes-and-mitochondrial-genome-in-professional-soccer-players%C3%A2-performance
#19
V Galeandro, A Notarnicola, A Bianco, S Tafuri, L Russo, V Pesce, B Moretti, V Petruzzella
Two nuclear genes, ACTN3, encoding for the α-actinin skeletal muscle isoform 3, and ACE encoding the angiotensin-converting enzyme, have both been associated with quantitative physical performance traits in the general population. The purpose of our study was to assess the association between the two nuclear gene variants, R577X (rs1815739) in ACTN3 and I/D (rs4340) in ACE, with elite athletes’ performance and the effect of training on the mitochondrial DNA (mtDNA) content in peripheral blood. We evaluated the genotypes and frequencies of ACTN3 R577X and ACE I/D polymorphisms between soccer players (n = 43) and healthy non-athletic controls (n = 128)...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28298259/phenotypic-analysis-of-asthma-in-japanese-athletes
#20
Keisuke Tsukioka, Toshiyuki Koya, Hiroshi Ueno, Masachika Hayashi, Takuro Sakagami, Takashi Hasegawa, Masaaki Arakawa, Eiichi Suzuki, Toshiaki Kikuchi
BACKGROUND: Asthma in athlete populations such as Olympic athletes has various pathogeneses. However, few reports are available on the features of asthma in the athlete population in clinical practice. In this study, we focused on classifying asthma in Japanese athlete population. METHODS: We performed a cluster analysis of data from pulmonary function tests and clinical biomarkers before administering inhaled corticosteroids (ICS) therapy in athlete population of individuals diagnosed with asthma (n = 104; male, 76...
March 12, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
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