keyword
https://read.qxmd.com/read/37637600/outpatient-treatment-of-refractory-morel-lavall%C3%A3-e-lesion-infection-with-retention-sutures-a-case-report
#21
Koji Miura
We report the case of a 41-year-old man with a Morel-Lavallée lesion (MLL) that developed an infection. The patient was initially treated with intravenous antibiotics, but the infection persisted. He was then treated with outpatient cleansing and retention sutures, which resulted in successful wound healing. This case report demonstrates the efficacy of outpatient cleansing and retention sutures for the treatment of MLL infection. This treatment modality is less expensive than inpatient treatment, and it allows the patient to return to their normal activities sooner...
July 2023: Curēus
https://read.qxmd.com/read/37606954/intravenous-cefazolin-achieves-sustained-high-interstitial-concentrations-in-open-lower-extremity-fractures
#22
JOURNAL ARTICLE
Taylor J Bates, Matthew B Burgess, Gerardo R Garcia, Kevin S Akers, Lee C Mangum, Thomas B Lynch, Joseph C Wenke, Sarah N Pierrie
BACKGROUND: Infection remains a serious clinical concern in patients with open fractures, despite timely antibiotic administration and surgical debridement. Soft tissue and periosteal stripping may alter local tissue homeostasis and antibiotic pharmacokinetics in the injured limb. The tissue (interstitial) concentration of intravenously administered antibiotics at an open fracture site has not been characterized using direct sampling techniques. QUESTION/PURPOSE: We performed this study to evaluate the concentration and pharmacokinetics of intravenously delivered cefazolin at an open fracture site after surgical debridement...
August 22, 2023: Clinical Orthopaedics and related Research
https://read.qxmd.com/read/37605488/prevention-and-management-of-drug-induced-osteonecrosis-of-the-jaws-using-platelet-rich-fibrin-a-clinical-feasibility-study
#23
JOURNAL ARTICLE
Abdusalam Alrmali, Muhammad H A Saleh, Salaheddin Mohamed S Kurdi, Hamoun Sabri, Mohamed M Meghil, Hom-Lay Wang
OBJECTIVE: Although a standard treatment guideline has not been established to date, various treatment modalities have been described in the literature based on the staging of medication-related osteonecrosis of the jaw (MRONJ). The aim of this case series was to describe the outcomes of surgical intervention of MRONJ cases with the adjunctive use of platelet-rich fibrin (PRF). MATERIALS AND METHODS: Thirteen patients under therapy with zoledronic acid, seven of them underwent surgical removal of necrotic bone with debridement, followed by placement of three to four PRF membranes and achieving primary closure...
August 21, 2023: Clinical and Experimental Dental Research
https://read.qxmd.com/read/37575261/exploring-the-contribution-of-pro-inflammatory-cytokines-to-impaired-wound-healing-in-diabetes
#24
REVIEW
S Nirenjen, J Narayanan, T Tamilanban, Vetriselvan Subramaniyan, V Chitra, Neeraj Kumar Fuloria, Ling Shing Wong, Gobinath Ramachawolran, Mahendran Sekar, Gaurav Gupta, Shivkanya Fuloria, Suresh V Chinni, Siddharthan Selvaraj
BACKGROUND: Impaired wound healing is the most common and significant complication of Diabetes. While most other complications of Diabetes have better treatment options, diabetic wounds remain a burden as they can cause pain and suffering in patients. Wound closure and repair are orchestrated by a sequence of events aided by the release of pro-inflammatory cytokines, which are dysregulated in cases of Diabetes, making the wound environment unfavorable for healing and delaying the wound healing processes...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37477409/national-open-abdomen-audit-noaa-protocol-for-an-observational-audit-of-the-use-and-management-of-the-open-abdomen-in-secondary-care-across-great-britain-and-ireland
#25
JOURNAL ARTICLE
Deepak Vijayan, Jonathan D Hodgkinson, Elizabeth Li, Thomas Pinkney, Dominic Slade
AIM: Use of open abdomen (OA) remains an important life-saving manoeuvre in the management of trauma and the abdominal catastrophe. The National Open Abdomen Audit (NOAA) is an audit project investigating the indications, management, and subsequent outcomes of OA treatment throughout the UK. The aim is to generate a snapshot of practice which will inform the management of future patients and potentially reduce the significant harm that can be associated with OA. METHODS AND ANALYSIS: NOAA is a collaborative, prospective observational audit recruiting patients from across Great Britain and Ireland...
July 2023: Colorectal Disease
https://read.qxmd.com/read/37464460/cochlear-implantation-in-radiation-induced-hearing-loss-a-systematic-review
#26
JOURNAL ARTICLE
Asma Alahmadi, Yassin Abdelsamad, Bassam Al-Zuraiqi, Saeed Alghamdi, Abdulrahman Hagr, Essam Saleh
OBJECTIVE: Cochlear implantation (CI) has been reported as a treatment modality for radiation-induced sensorineural hearing loss (SNHL). However, its efficacy is based on individual reports with no cumulative supporting evidence. Therefore, we conducted the current systematic review to provide cumulative evidence regarding the feasibility and safety of CI in this context. DATABASES REVIEWED: An online bibliographic search was conducted in PubMed, ProQuest, Scopus, Google Scholar, and Web of Science using MeSH-based terms...
July 18, 2023: Otology & Neurotology
https://read.qxmd.com/read/37403007/the-evolving-treatment-landscape-of-merkel-cell-carcinoma
#27
REVIEW
Neha Singh, Erin M McClure, Tomoko Akaike, Song Y Park, Emily T Huynh, Peter H Goff, Paul Nghiem
Merkel cell carcinoma (MCC) has a high risk of recurrence and requires unique treatment relative to other skin cancers. The patient population is generally older, with comorbidities. Multidisciplinary and personalized care is therefore paramount, based on patient preferences regarding risks and benefits. Positron emission tomography and computed tomography (PET-CT) is the most sensitive staging modality and reveals clinically occult disease in ~ 16% of patients. Discovery of occult disease spread markedly alters management...
July 5, 2023: Current Treatment Options in Oncology
https://read.qxmd.com/read/37337031/hoxa3-accelerates-wound-healing-in-diabetic-and-aged-non-diabetic-mammals
#28
JOURNAL ARTICLE
K Parella, K Moody, D Wortel, H Colegrove, J A Elser
Chronic wounds are characterized by a persistent, hyper-inflammatory environment that prevents progression to regenerative wound closure. Such chronic wounds are especially common in diabetic patients, often requiring distal limb amputation, but occur in non-diabetic, elderly patients as well. Induced expression of HoxA3, a member of the Homeobox family of body patterning and master regulatory transcription factors, has been shown to accelerate wound closure in diabetic mice when applied topically as a plasmid encased in a hydrogel...
June 19, 2023: Scientific Reports
https://read.qxmd.com/read/37333040/integra%C3%A2-dermal-regeneration-matrix-a-versatile-solution-for-complex-soft-tissue-sarcoma-reconstruction-in-the-hand
#29
Ramy Samargandi
This case report describes the successful use of Integra® (Integra LifeSciences Corporation, Plainsboro, New Jersey, United States), an artificial skin substitute, for the reconstruction of soft tissue defects following soft tissue sarcoma resection. We present a case of a 75-year-old female presented with a progressively enlarging lesion on her right hand. Imaging revealed tumor involvement in the extensor tendons and adjacent to the index finger tendon. A percutaneous biopsy confirmed an undifferentiated pleomorphic sarcoma...
June 2023: Curēus
https://read.qxmd.com/read/37224465/healing-exposed-calvarial-hardware-using-negative-pressure-wound-therapy-and-vashe-wound-solution-case-report
#30
JOURNAL ARTICLE
Kyle M Ockerman, Elizabeth A Cox, Gayle Wiesemann, D Spencer Nichols, Gregory J A Murad, Jessica Ching, Sarah Sorice-Virk
OBJECTIVE: The management of cranioplasty infections has historically been explantation followed by delayed reimplantation/reconstruction. This treatment algorithm necessitates surgery, tissue expansion, and prolonged disfigurement. In this report, the authors describe a treatment approach consisting of serial vacuum-assisted closure (VAC) with hypochlorous acid (HOCl) solution (Vashe Wound Solution; URGO Medical) as a salvage strategy. METHODS: A 35-year-old man who sustained head trauma, neurosurgical complications, and severe syndrome of the trephined (SOT; devastating neurologic decline treated by cranioplasty) underwent titanium cranioplasty with free flap...
May 25, 2023: Advances in Skin & Wound Care
https://read.qxmd.com/read/37220254/rotation-flap-closure-of-pressure-injuries-following-negative-pressure-wound-therapy-with-instillation-for-wound-cleansing
#31
JOURNAL ARTICLE
Michael Desvigne, Krista Montgomery, Kurt Holifield, Kari Day, Denise Gilmore, Ashley L Wardman
INTRODUCTION: Wound cleansing is integral during early-stage wound management and affords the transition to modalities promoting granulation tissue formation and reepithelialization, or preparation for wound coverage/closure. NPWTi-d includes periodic instillation of topical wound cleansing solutions and negative pressure for infectious material removal. MATERIALS AND METHODS: This was a retrospective study of 5 patients who were admitted to an acute care hospital and treated for PI...
April 2023: Wounds: a Compendium of Clinical Research and Practice
https://read.qxmd.com/read/37184839/topical-esmolol-hydrochloride-as-a-novel-treatment-modality-for-diabetic-foot-ulcers-a-phase-3-randomized-clinical-trial
#32
RANDOMIZED CONTROLLED TRIAL
Ashu Rastogi, Sudhir A Kulkarni, Sanjay Agarwal, Murtaza Akhtar, Sachin Arsule, Sudhir Bhamre, Deepak Bhosle, Sanjay Desai, Manisha Deshmukh, K V Giriraja, Jagannath Jagannath, Reema Yuvraj Kashiva, Rajesh Kesavan, Deepak Khandelwal, Sanjay Kolte, Srikanth Kongara, Anil Kumar Darivemula, C Madhusudan, Mohammad Asif Haji Pyare Saheb Qureshi, Muthu Ramu, Gunvant Rathod, Sadasiva Rao Yalamanchi, Shobhit Shakya, Prathvi Shetty, Sudagar Singh, Supreet K Deshpande, Vijay Viswanathan, Ambika G Unnikrishnan
IMPORTANCE: Preclinical and phase 1/2 studies with esmolol hydrochloride suggest its potential role in treatment of diabetic foot ulcers (DFUs). OBJECTIVE: To study the efficacy of topical esmolol for healing of uninfected DFUs. DESIGN, SETTING, AND PARTICIPANTS: A randomized, double-blind, multicenter, phase 3 clinical trial was conducted from December 26, 2018, to August 19, 2020, at 27 referral centers across India. Participants included adults with DFUs...
May 1, 2023: JAMA Network Open
https://read.qxmd.com/read/37153335/cable-ties-poor-man-s-top-closure-system
#33
Aditya Narayan Choudhary, Sanjeev Kumar
Scalp electrical burns unsuitable for primary closure after debridement have traditionally been treated by modalities that cause significant morbidity and are aesthetically inferior to tension-free primary wound closure. Due to advances in research on the biomechanical properties of skin, various devices for skin stretching and safe wound closure have been reported in the literature that are expensive and inaccessible to poor people in the developing countries. We present our experience using cable ties as an effective, easy to use, readily available, and inexpensive top closure system...
April 2023: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://read.qxmd.com/read/37149909/the-current-state-of-knowledge-on-how-to-improve-skin-flap-survival-a-review
#34
REVIEW
Arya Afrooghe, Amirmasoud Rayati Damavandi, Elham Ahmadi, Razieh Mohammad Jafari, Ahmad Reza Dehpour
The incorporation of skin flaps in wound closure management with its cosmetic implications has appeared as a gleam of hope in providing desirable outcomes. Given the influence of extrinsic and intrinsic factors, skin flaps are prone to several complications, including ischemia-reperfusion injury (IRI). Numerous attempts have been undertaken to enhance the survival rate of skin flaps entailing pre/post-conditioning with surgical and pharmacological modalities. Various cellular and molecular mechanisms are employed in these approaches in order to reduce inflammation, promote angiogenesis and blood perfusion, and induce apoptosis and autophagy...
April 17, 2023: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://read.qxmd.com/read/37146110/single-use-negative-pressure-wound-therapy-applied-on-various-wound-types-an-interventional-case-series
#35
JOURNAL ARTICLE
Neha Amin, Bounthavy Homsombath, John Rumbaugh, Beretta Craft-Coffman, Shawn P Fagan, Tayseer Chowdhry, Joan Wilson, Rey Paglinawan, Karin Lussi, Zaheed Hassan
PURPOSE: The purpose of this study was to determine whether a single-use negative pressure wound therapy (NPWT) system achieves individualized goals of therapy when used to treat patients with a variety of wound types. DESIGN: Multiple case series. SUBJECTS AND SETTING: The same comprised 25 participants; their mean age was 51.2 years (SD: 18.2; range: 19-79 years); 14 were male (56%) and 11 were female (44%). Seven study participants withdrew from study participation...
May 2023: Journal of Wound, Ostomy, and Continence Nursing
https://read.qxmd.com/read/37024600/patient-specific-computational-simulations-of-wound-healing-following-midline-laparotomy-closure
#36
JOURNAL ARTICLE
Ali Akbar Karkhaneh Yousefi, Baptiste Pierrat, Anicet Le Ruyet, Stéphane Avril
In the current study, we developed a new computational methodology to simulate wound healing in soft tissues. We assumed that the injured tissue recovers partially its mechanical strength and stiffness by gradually increasing the volume fraction of collagen fibers. Following the principles of the constrained mixture theory, we assumed that new collagen fibers are deposited at homeostatic tension while the already existing tissue undergoes a permanent deformation due to the effects of remodeling. The model was implemented in the finite-element software Abaqus® through a VUMAT subroutine and applied to a complex and realistic case: simulating wound healing following midline laparotomy closure...
October 2023: Biomechanics and Modeling in Mechanobiology
https://read.qxmd.com/read/36891041/a-case-series-of-autologous-platelet-rich-plasma-injection-in-treating-chronic-ulcers-conducted-in-saudi-arabia
#37
Sinan F Tabanjeh, Talal Al-Malki, Rola Al Kharabsheh, Danish Mahmood
OBJECTIVE: This is a case series study of 14 cases of chronic unhealed ulcers involving patients of 19-85 years, aimed to demonstrate the positive therapeutic outcomes of using autologous platelet rich plasma (PRP) in diabetic foot ulcer (DFU) and other chronic wound healing. METHODS: This is a formal consecutive clinical case series. Patients with chronic unhealed ulcers were enrolled from the amputation prevention clinic by an interdisciplinary team includes podiatrist, general surgeon, orthopedic, vascular surgeon, and wound care nurses at Kahel Specialized Centre, a specialized center for managing foot and ankle diseases, located in Riyadh, Saudi Arabia...
2023: International Journal of Health Sciences
https://read.qxmd.com/read/36749998/peroneus-brevis-muscle-flap-for-a-20-year-old-neuroischemic-diabetic-ulcer-induced-by-traumatic-injury-a-case-report-detailing-the-efficacy-of-advanced-combined-treatment-modalities-for-chronic-wound-closure
#38
JOURNAL ARTICLE
Alex Bischoff, Ryan Stone, Amanda Quisno, Samantha Figas, Andrew Pierre
INTRODUCTION: Peroneus brevis flaps provide a viable option to achieve soft tissue coverage in hard-to-heal lower extremity wounds, specifically those to the lateral ankle and hindfoot. CASE REPORT: The authors present a unique case of a patient with a 20-year-old wound dehiscence complicated by osteomyelitis. The wound was a complication from a lateral extensile incision utilized during prior calcaneal open reduction and internal fixation. Due to many factors, including multiple comorbidities, the patient could not obtain complete healing despite IV antibiotics, vascular optimization, local wound care, surgical debridement, and grafting...
January 2023: Wounds: a Compendium of Clinical Research and Practice
https://read.qxmd.com/read/36715957/the-developments-in-amniotic-membrane-transplantation-in-glaucoma-and-vitreoretinal-procedures
#39
REVIEW
Rohit Sharma, Vivian Nappi, Theodoros Empeslidis
The main reasons why Amniotic Membrane (AM) is transplanted in Ophthalmology are: to provide a substrate for cellular growth and to provide tectonic support or as a biological bandage and barrier that protects the wound to facilitate an environment for wound healing. The application of AM is well-documented in corneal disorders of various aetiologies [1], however, research within the field has highlighted how it can be used in conjunctival disorders and most recently, in glaucoma and vitreoretinal procedures...
January 30, 2023: International Ophthalmology
https://read.qxmd.com/read/36643387/clinical-observation-of-sequential-laser-therapy-combined-with-tension-reducer-for-postoperative-tension-incision-scar-growth
#40
JOURNAL ARTICLE
Ting-Yu Wang, Zi-Qing Ye, Weiguo Xie
OBJECTIVE: To investigate the clinical effectiveness of laser and secure wound-closure system (Tension reducer) in the treatment of postoperative scarring after tension incision. METHODS: A retrospectively observational study was conducted. Twenty-six patients who underwent surgical treatment in our department between June 2017 and December 2021 were selected, and those treated with laser and tension reducer were treated as a combined treatment group, and those treated with laser were treated as a conventional treatment group...
2023: Clinical, Cosmetic and Investigational Dermatology
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