Ashu Rastogi, Sudhir A Kulkarni, Sanjay Agarwal, Murtaza Akhtar, Sachin Arsule, Sudhir Bhamre, Deepak Bhosle, Sanjay Desai, Manisha Deshmukh, K V Giriraja, Jagannath Jagannath, Reema Yuvraj Kashiva, Rajesh Kesavan, Deepak Khandelwal, Sanjay Kolte, Srikanth Kongara, Anil Kumar Darivemula, C Madhusudan, Mohammad Asif Haji Pyare Saheb Qureshi, Muthu Ramu, Gunvant Rathod, Sadasiva Rao Yalamanchi, Shobhit Shakya, Prathvi Shetty, Sudagar Singh, Supreet K Deshpande, Vijay Viswanathan, Ambika G Unnikrishnan
IMPORTANCE: Preclinical and phase 1/2 studies with esmolol hydrochloride suggest its potential role in treatment of diabetic foot ulcers (DFUs). OBJECTIVE: To study the efficacy of topical esmolol for healing of uninfected DFUs. DESIGN, SETTING, AND PARTICIPANTS: A randomized, double-blind, multicenter, phase 3 clinical trial was conducted from December 26, 2018, to August 19, 2020, at 27 referral centers across India. Participants included adults with DFUs...
May 1, 2023: JAMA Network Open