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Wound closure modality

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https://www.readbyqxmd.com/read/27649406/comparing-the-efficacy-of-viable-cryopreserved-placental-membrane-for-the-treatment-of-wounds-of-diverse-etiologies
#1
Derek S Anselmo, Marc Karpo, Ebony Love, Tracey Vlahovic
INTRODUCTION AND OBJECTIVES: The benefits of using amniotic tissue in skin regeneration are well documented. Today, cryopreservation technology allows for better availability and maintenance of mesenchymal stem cells. This is of particular interest in treating the diabetic foot ulcer as this population has fewer mesenchymal stem cells. The objective of this case series investigation was to compare the efficacy of cryopreserved human amniotic stem cells in treating foot wounds of different etiologies...
September 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27617409/a-randomized-controlled-multicentre-clinical-trial-of-post-extraction-alveolar-ridge-preservation
#2
Eric Todd Scheyer, Rick Heard, Jim Janakievski, George Mandelaris, Marc L Nevins, Stephen R Pickering, Christopher R Richardson, Bryan Pope, Gregory Toback, Diego Velásquez, Heiner Nagursky
AIM: To compare the effectiveness of two-ridge preservation treatments. MATERIALS AND METHODS: Forty subjects with extraction sockets exhibiting substantial buccal dehiscences were enrolled and randomized across 10 standardized centres. Treatments were demineralized allograft plus reconstituted and cross-linked collagen membrane (DFDBA + RECXC) or deproteinized bovine bone mineral with collagen plus native, bilayer collagen membrane (DBBMC + NBCM). Socket dimensions were recorded at baseline and 6 months...
December 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27607352/titanium-wound-chambers-for-wound-healing-research
#3
Kristo Nuutila, Mansher Singh, Carla Kruse, Justin Philip, Edward J Caterson, Elof Eriksson
Standardized and reproducible animal models are crucial in medical research. Rodents are commonly used in wound healing studies since, they are easily available, affordable and simple to handle and house. However, the most significant limitation of rodent models is that the wounds heal by contraction while in humans the primary mechanisms of healing are reepithelialization and granulation tissue formation. The robust contraction results in faster wound closure that complicates the reproducibility of rodent studies in clinical trials...
September 8, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27563616/regeneration-of-mandibular-ameloblastoma-defect-with-the-help-of-autologous-dental-pulp-stem-cells-and-buccal-pad-of-fat-stromal-vascular-fraction
#4
K Manimaran, Rohini Sharma, S Sankaranarayanan, S Mahendra Perumal
Ameloblastoma is benign odontogenic tumor, which is locally aggressive in behavior. Till date, the treatment of choice is resection and reconstruction using a variety of modalities. Inadequate resection may lead to many complications such as bone deformity and dysfunction. This report is about a 14-year-old male with ameloblastoma treated with autologous dental pulp stem cells (DPSCs) and stromal vascular fraction (SVF) and evidence of bone regeneration. Marsupialization was performed; tooth was extracted and sent for DPSC cultivation...
January 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/27556755/the-role-of-dermal-matrices-in-treating-inflammatory-and-diabetic-wounds
#5
Mihail Climov, Lauren R Bayer, Andrea V Moscoso, Hajime Matsumine, Dennis P Orgill
BACKGROUND: Dermal matrices are used to improve healing in both acute and chronic wounds including diabetic and lower extremity wounds, burns, trauma, and surgical reconstruction. The use of dermal matrices for the closure of inflammatory ulcerations is less frequent but growing. Currently available products include decellularized dermis and semisynthetic matrices. METHODS: A review of the published literature was performed to identify reports that use acellular dermal matrices in diabetic and inflammatory wounds...
September 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27509412/on-the-significance-of-negative-pressure-wound-therapy-with-instillation-in-dermatology
#6
REVIEW
Cornelia Sigrid Lissi Müller, Barbara Burgard, Monika Zimmerman, Thomas Vogt, Claudia Pföhler
Methods used in the treatment of acute and chronic wounds undergo constant evolution, reevaluation, and innovation. While negative-pressure wound therapy (NPWT) is an established treatment modality, the combination of NPWT and instillation of normal saline as well as solutions with active antiseptic components for topical treatment of the wound bed represents a novel approach. The well-known effects of NPWT may thus be combined with those of local antisepsis. They include a decrease in wound area, induction of granulation tissue, and reduction in bacterial colonization...
August 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27506662/impact-of-flap-reconstruction-on-radiotoxicity-after-salvage-surgery-and-reirradiation-for-recurrent-head-and-neck-cancer
#7
Allen S Ho, Zachary S Zumsteg, Annika Meyer, Nadeem Riaz, Rahmatullah Rahmati, Dennis H Kraus, Colleen McCarthy, Richard J Wong, Jatin P Shah, Nancy Y Lee
BACKGROUND: Recurrent head and neck malignancies remain a therapeutic challenge. Tissue transfer, in addition to defect coverage and prevention of wound complications, may potentially decrease radiotoxicity. We evaluated radiation toxicity and survival outcomes of patients who underwent salvage surgery with reirradiation, comparing primary closure to flap reconstruction. METHODS: Retrospective outcomes analysis of recurrent head and neck squamous cell carcinoma (HNSCC) patients treated with curative intent by salvage surgery (± flap reconstruction) and reirradiation from 1996 to 2011...
August 9, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27410466/a-single-centre-retrospective-study-of-cryopreserved-umbilical-cord-amniotic-membrane-tissue-for-the-treatment-of-diabetic-foot-ulcers
#8
A Raphael
OBJECTIVE: Histopathological studies have shown a prolonged inflammatory phase in wounds of patients with diabetes, delaying formation of mature granulation tissue and reducing wound tensile strength, making these wounds difficult for physicians to heal. Cryopreserved human umbilical cord (cUC) tissues possess unique anti-inflammatory and anti-scarring properties and have been found to help improve closure of these chronic wounds. METHOD: A retrospective chart review was performed to assess the efficacy of cUC as an advanced treatment modality to help promote the closure of chronic DFUs...
July 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27328431/engineered-human-vascularized-constructs-accelerate-diabetic-wound-healing
#9
Yu-I Shen, Hongkwan Cho, Arianne E Papa, Jacqueline A Burke, Xin Yi Chan, Elia J Duh, Sharon Gerecht
Stem cell-based therapy is emerging as a promising approach for chronic diabetic wounds, but strategies for optimizing both cellular differentiation and delivery remain as major obstacles. Here, we study bioengineered vascularized constructs as a therapeutic modality for diabetic wound healing. We developed a wound model in immunodeficient rodent and treated it with engineered vascularized constructs from endothelial progenitors or early vascular cells-derived from human induced pluripotent stem cells (hiPSCs) reprogrammed either from healthy donor or type-1 diabetic patient...
September 2016: Biomaterials
https://www.readbyqxmd.com/read/27185033/epidermal-grafting-versus-split-thickness-skin-grafting-for-wound-healing-epigraaft-study-protocol-for-a-randomised-controlled-trial
#10
Muholan Kanapathy, Nadine Hachach-Haram, Nicola Bystrzonowski, Keith Harding, Afshin Mosahebi, Toby Richards
BACKGROUND: Split-thickness skin grafting (SSG) is an important modality for wound closure. However, the donor site becomes a second, often painful wound, which may take more time to heal than the graft site itself and holds the risk of infection and scarring. Epidermal grafting (EG) is an alternative method of autologous skin grafting that harvests only the epidermal layer of the skin by applying continuous negative pressure on the normal skin to raise blisters. This procedure has minimal donor site morbidity and is relatively pain-free, allowing autologous skin grafting in an outpatient setting...
May 17, 2016: Trials
https://www.readbyqxmd.com/read/27121406/systematic-and-specific-treatment-of-patients-with-enteroatmospheric-fistulas-from-initial-conservative-treatment-to-definitive-surgery
#11
Daniel E Wainstein, Pablo Sisco, María L Deforel, Mariano Irigoyen, Jorge Devoto, Juan M Zarate
INTRODUCTION: The open abdomen is a widespread therapeutic resource; however, it is also a source of complications, of which the enteroatmospheric fistulas (EAFs) pose one of the greatest problems. The objective of this study was to describe the implemented strategy for handling enteroatmospheric fistulas, and secondarily, to analyze the differential results based on a change in the conservative local treatment specifically designed for the stated complication. MATERIALS AND METHODS: From March 2002 to March 2014, patients treated for EAF were retrospectively analyzed...
April 2016: Surgical Technology International
https://www.readbyqxmd.com/read/27081708/esophageal-perforation-after-anterior-cervical-spine-surgery-a-systematic-review-of-the-literature
#12
Sameer H Halani, Griffin R Baum, Jonathan P Riley, Gustavo Pradilla, Daniel Refai, Gerald E Rodts, Faiz U Ahmad
OBJECTIVE Esophageal perforation is a rare but well-known complication of anterior cervical spine surgery. The authors performed a systematic review of the literature to evaluate symptomatology, direct causes, repair methods, and associated complications of esophageal injury. METHODS A PubMed search that adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines included relevant clinical studies and case reports (articles written in the English language that included humans as subjects) that reported patients who underwent anterior spinal surgery and sustained some form of esophageal perforation...
September 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27054636/staged-repair-of-severe-open-abdomens-due-to-high-energy-gunshot-injuries-with-early-vacuum-pack-and-delayed-tissue-expansion-and-dual-sided-meshes
#13
Doğan Alhan, İsmail Şahin, Serbülent Güzey, Andaç Aykan, Fatih Zor, Serdar Öztürk, Mustafa Nışancı, İsmail Hakkı Özerhan
BACKGROUND: Open abdomen is a salvage procedure that prevents catastrophes after severe intraabdominal traumas. However, following this life saving attempt, it is mostly not feasible to close the abdomen immediately after the recovery of intraabdominal injuries. Consequently, a staged reconstruction is required, and the first stage is usually a temporary closing approach. At the end of this stage, resulting giant "ventral hernia" is a burden for both the patient and the surgeon. Therefore a permanent repair is subsequently needed...
December 2015: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/26947696/negative-pressure-wound-therapy-versus-standard-wound-care-on-quality-of-life-a-systematic-review
#14
REVIEW
A H J Janssen, E H H Mommers, J Notter, T S de Vries Reilingh, J A Wegdam
OBJECTIVE: Negative pressure wound therapy (NPWT) is a widely accepted treatment modality for open or infected wounds. Premature ending of NPWT occasionally occurs due to negative effects on the quality of life (QoL), however, the actual impact on QoL is unknown. The aim of this review is to analyse the effect of NPWT versus standard wound care (SWC) on QoL when used for the treatment of open or infected wounds. METHOD: A systematic literature search in a range of databases (PubMed, CINAHL, Medline, Web of Science, Science Direct Freedom Collection, SwetsWise, PSYCArticles and Infrotrac Custom Journals) using the following search terms; 'standard wound care', 'wound dressing', 'dressing', 'treatment', OR 'negative pressure wound therapy [MESH]', OR 'vacuum assisted closure' AND 'quality of life [MESH]', 'patient-satisfaction', OR 'experiences' was performed...
March 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/26908418/-impact-of-vacuum-assisted-closure-management-in-deep-neck-abscesses
#15
Luis Humberto Govea-Camacho, Andrea Astudillo-Carrera, José Manuel Hermosillo-Sandoval, Sergio Rodríguez-Reynoso, Alejandro González-Ojeda, Clotilde Fuentes-Orozco
BACKGROUND: The presence of deep neck abscesses is potentially serious; they can lead to death in a short period of time. The vacuum-assisted closure (V.A.C.) therapy has been used in many areas of surgery for complex wound healing. This treatment modality has recently been considered in the field of head and neck surgery. OBJECTIVE: Evaluate the efficacy of healing therapy using V.A.C. therapy in deep neck abscesses. MATERIAL AND METHODS: Open-label trial...
July 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/26785708/wide-excision-and-healing-by-secondary-intent-for-the-surgical-treatment-of-hidradenitis-suppurativa-a-single-center-experience
#16
Laura S Humphries, Essie Kueberuwa, Maureen Beederman, Lawrence J Gottlieb
BACKGROUND: This study reviewed a single center's 14-year experience with surgical treatment of chronic, severe hidradenitis suppurativa (HS) through wide excision technique and healing by secondary intention. METHODS: All patients who underwent wide excision of HS between 2000 and 2014 and allowed to heal by secondary intention were included. Wound care consisted of topical antimicrobials and hydrotherapy. Physical therapy was initiated for joint contracture prevention...
April 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/26764549/dislocation-of-a-constrained-total-knee-arthroplasty-with-patellar-tendon-rupture-after-trivial-trauma
#17
Raju Vaishya, Vipul Vijay, Abhishek Vaish
Constrained total knee prostheses are used in knees with severe deformities and insufficiency of collaterals to provide stable and mobile knees. Dislocation after constrained knee prosthesis is an extremely rare and dreaded complication. When dislocation is associated with patellar tendon rupture, the management includes restoration of the extensor apparatus along with a stable knee. Repair of the patellar tendon is challenging due to poor soft tissue coverage in the area and a bulky repair can put tension on the wound closure...
2015: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/26745523/cosmetic-outcomes-of-sutureless-closure-in-gastroschisis
#18
Andrzej Zajac, Bartosz Bogusz, Piotr Soltysiak, Przemyslaw Tomasik, Michal Wolnicki, Andrzej Wedrychowicz, Piotr Wojciechowski, Wojciech Gorecki
Purpose A sutureless gastroschisis repair allows for spontaneous closure of abdominal wall defect. We report our experience focusing on final esthetic outcome. Methods Retrospective data were collected from medical reports of all neonates with gastroschisis operated from January 2009 to December 2013. Variables recorded included patients descriptors, management modality, and cosmetic outcome. Results From the overall group of 38 patients with gastroschisis, 20 infants treated with sutureless closure were included in this study...
December 2016: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26649152/evolution-and-advances-in-laparoscopic-ventral-and-incisional-hernia-repair
#19
REVIEW
Alan L Vorst, Christodoulos Kaoutzanis, Alfredo M Carbonell, Michael G Franz
Primary ventral hernias and ventral incisional hernias have been a challenge for surgeons throughout the ages. In the current era, incisional hernias have increased in prevalence due to the very high number of laparotomies performed in the 20(th) century. Even though minimally invasive surgery and hernia repair have evolved rapidly, general surgeons have yet to develop the ideal, standardized method that adequately decreases common postoperative complications, such as wound failure, hernia recurrence and pain...
November 27, 2015: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/26468835/outcomes-of-vacuum-assisted-therapy-in-the-treatment-of-head-and-neck-wounds
#20
Ellen S Satteson, John Clayton Crantford, Jeyhan Wood, Lisa R David
INTRODUCTION: Head and neck wounds can present a reconstructive challenge for the plastic surgeon. Whether from skin cancer, trauma, or burns, there are many different treatment modalities used to dress and manage complex head and neck wounds. Vacuum-assisted closure (VAC) therapy has been used on wounds of nearly every aspect of the body but not routinely in the head and neck area. This study was conducted to demonstrate our results using the VAC in the treatment of complex head and neck wounds...
October 2015: Journal of Craniofacial Surgery
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