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Wound closure modality

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https://www.readbyqxmd.com/read/28424334/glycosaminoglycan-based-hydrogels-capture-inflammatory-chemokines-and-rescue-defective-wound-healing-in-mice
#1
Nadine Lohmann, Lucas Schirmer, Passant Atallah, Elke Wandel, Ruben A Ferrer, Carsten Werner, Jan C Simon, Sandra Franz, Uwe Freudenberg
Excessive production of inflammatory chemokines can cause chronic inflammation and thus impair cutaneous wound healing. Capturing chemokine signals using wound dressing materials may offer powerful new treatment modalities for chronic wounds. Here, a modular hydrogel based on end-functionalized star-shaped polyethylene glycol (starPEG) and derivatives of the glycosaminoglycan (GAG) heparin was customized for maximal chemokine sequestration. The material is shown to effectively scavenge the inflammatory chemokines MCP-1 (monocyte chemoattractant protein-1), IL-8 (interleukin-8), and MIP-1α (macrophage inflammatory protein-1α) and MIP-1β (macrophage inflammatory protein-1β) in wound fluids from patients suffering from chronic venous leg ulcers and to reduce the migratory activity of human monocytes and polymorphonuclear neutrophils...
April 19, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28368916/topical-negative-pressure-wound-therapy-of-burned-hands-functional-outcomes
#2
Denis Ehrl, Paul I Heidekrueger, P Niclas Broer, Holger C Erne
Extensive partial- and full-thickness burns, especially of the hands, continue to pose a surgical challenge. With improved knowledge regarding fluid balance, burn pathophysiology, and lately also given the introduction of topical negative pressure wound (TNPW) therapy, treatment regimes have changed in many burn centers. The authors evaluated the results regarding long-term outcomes of patients with partial- and full-thickness burns of the hands treated with TNPW. Over a period of 72 months, 51 patients with 80 hand burns received TNPW treatment...
March 31, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28116226/a-retrospective-comparison-of-the-performance-of-two-negative-pressure-wound-therapy-systems-in-the-management-of-wounds-of-mixed-etiology
#3
Theresa Hurd, Alan Rossington, Paul Trueman, Jennifer Smith
Objective: Negative pressure wound therapy (NPWT) has been shown to be effective in the management of chronic and surgical wounds. The two most widely used modalities of NPWT are vacuum-assisted closure (V.A.C.) therapy (KCI, Inc., San Antonio, Texas) and the RENASYS NPWT system (Smith & Nephew, Hull, United Kingdom). This evaluation compares the performance of the two systems in the management of wounds of mixed etiology. Approach: The evaluation is based on retrospective evaluation of more than 1,000 patients treated with NPWT in a community setting in Canada...
January 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28090519/a-rare-case-of-a-blood-clot-masquerading-as-a-retained-surgical-drain
#4
Sean Wl Ho, Ivan Th Chua
Surgical drains are commonly used in surgery to reduce post-operative fluid collections. Whilst rare, a retained surgical drain may result in clinical complications and distress to the patient. A retained surgical drain is a potentially avoidable event and surgeons should be aware on how to confirm the presence of a retained surgical drain. We report a rare case of a blood clot masquerading as a retained surgical drain in a patient. The patient is a 55-year-old Malay male who presented with left gluteal necrotizing fasciitis...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28058229/systematic-review-of-the-negative-pressure-wound-therapy-in-kidney-transplant-recipients
#5
Badri Man Shrestha
AIM: To review negative pressure wound therapy (NPWT) as an important addition to the conventional methods of wound management. METHODS: A systematic review, performed by searching the PubMed, EMBASE and Cochrane Library databases, showed 11 case reports comprising a total of 22 kidney transplantation (KT) patients (range, 1 to 9), who were treated with NPWT. Application of NPWT was associated with successful healing of wounds, leg ulcer, lymphocele and urine leak from ileal conduit...
December 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27988849/bacterial-reduction-and-shift-with-npwt-after-surgical-debridements-a-retrospective-cohort-study
#6
Thorsten Jentzsch, Georg Osterhoff, Pawel Zwolak, Burkhardt Seifert, Valentin Neuhaus, Hans-Peter Simmen, Gerrolt N Jukema
BACKGROUND: Surgical debridement, negative-pressure wound therapy (NPWT) and antibiotics are used for the treatment of open wounds. However, it remains unclear whether this treatment regimen is successful in the reduction and shift of the bacterial load. METHODS: After debridement in the operating room, NPWT, and antibiotic treatment, primary and secondary consecutive microbiological samples of 115 patients with 120 open wounds with bacterial or yeast growth in ≥1 swab or tissue microbiological sample(s) were compared for bacterial growth, Gram staining and oxygen use at a level one trauma center in 2011...
January 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27980886/a-case-review-series-of-christiana-care-health-system-s-experience-with-negative-pressure-wound-therapy-instillation
#7
Robert Felte, Kathy E Gallagher, Glen H Tinkoff, Mark Cipolle
Acute and chronic wounds afflict a multitude of patients to varying degrees. Wound care treatment modalities span the spectrum of technological advancement and with that differ greatly in cost. Negative pressure wound therapy (NPWT) can now be combined with instillation and dwell time (NPWTi-d). This case review series of 11 patients in a community hospital setting provides support for the utilization of NPWTi-d. Additionally, current literature on the use of NPWTi-d in comparison to NPWT will be reviewed.  We highlight three specific cases...
November 7, 2016: Curēus
https://www.readbyqxmd.com/read/27649406/comparing-the-efficacy-of-viable-cryopreserved-placental-membrane-for-the-treatment-of-wounds-of-diverse-etiologies
#8
Derek S Anselmo, Marc Karpo, Ebony Love, Tracey Vlahovic
INTRODUCTION AND OBJECTIVES: The benefits of using amniotic tissue in skin regeneration are well documented. Today, cryopreservation technology allows for better availability and maintenance of mesenchymal stem cells. This is of particular interest in treating the diabetic foot ulcer as this population has fewer mesenchymal stem cells. The objective of this case series investigation was to compare the efficacy of cryopreserved human amniotic stem cells in treating foot wounds of different etiologies...
September 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27617409/a-randomized-controlled-multicentre-clinical-trial-of-post-extraction-alveolar-ridge-preservation
#9
Eric Todd Scheyer, Rick Heard, Jim Janakievski, George Mandelaris, Marc L Nevins, Stephen R Pickering, Christopher R Richardson, Bryan Pope, Gregory Toback, Diego Velásquez, Heiner Nagursky
AIM: To compare the effectiveness of two-ridge preservation treatments. MATERIALS AND METHODS: Forty subjects with extraction sockets exhibiting substantial buccal dehiscences were enrolled and randomized across 10 standardized centres. Treatments were demineralized allograft plus reconstituted and cross-linked collagen membrane (DFDBA + RECXC) or deproteinized bovine bone mineral with collagen plus native, bilayer collagen membrane (DBBMC + NBCM). Socket dimensions were recorded at baseline and 6 months...
December 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27607352/titanium-wound-chambers-for-wound-healing-research
#10
Kristo Nuutila, Mansher Singh, Carla Kruse, Justin Philip, Edward J Caterson, Elof Eriksson
Standardized and reproducible animal models are crucial in medical research. Rodents are commonly used in wound healing studies since, they are easily available, affordable and simple to handle and house. However, the most significant limitation of rodent models is that the wounds heal by contraction while in humans the primary mechanisms of healing are reepithelialization and granulation tissue formation. The robust contraction results in faster wound closure that complicates the reproducibility of rodent studies in clinical trials...
November 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27563616/regeneration-of-mandibular-ameloblastoma-defect-with-the-help-of-autologous-dental-pulp-stem-cells-and-buccal-pad-of-fat-stromal-vascular-fraction
#11
K Manimaran, Rohini Sharma, S Sankaranarayanan, S Mahendra Perumal
Ameloblastoma is benign odontogenic tumor, which is locally aggressive in behavior. Till date, the treatment of choice is resection and reconstruction using a variety of modalities. Inadequate resection may lead to many complications such as bone deformity and dysfunction. This report is about a 14-year-old male with ameloblastoma treated with autologous dental pulp stem cells (DPSCs) and stromal vascular fraction (SVF) and evidence of bone regeneration. Marsupialization was performed; tooth was extracted and sent for DPSC cultivation...
January 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/27556755/the-role-of-dermal-matrices-in-treating-inflammatory-and-diabetic-wounds
#12
Mihail Climov, Lauren R Bayer, Andrea V Moscoso, Hajime Matsumine, Dennis P Orgill
BACKGROUND: Dermal matrices are used to improve healing in both acute and chronic wounds including diabetic and lower extremity wounds, burns, trauma, and surgical reconstruction. The use of dermal matrices for the closure of inflammatory ulcerations is less frequent but growing. Currently available products include decellularized dermis and semisynthetic matrices. METHODS: A review of the published literature was performed to identify reports that use acellular dermal matrices in diabetic and inflammatory wounds...
September 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27509412/on-the-significance-of-negative-pressure-wound-therapy-with-instillation-in-dermatology
#13
REVIEW
Cornelia Sigrid Lissi Müller, Barbara Burgard, Monika Zimmerman, Thomas Vogt, Claudia Pföhler
Methods used in the treatment of acute and chronic wounds undergo constant evolution, reevaluation, and innovation. While negative-pressure wound therapy (NPWT) is an established treatment modality, the combination of NPWT and instillation of normal saline as well as solutions with active antiseptic components for topical treatment of the wound bed represents a novel approach. The well-known effects of NPWT may thus be combined with those of local antisepsis. They include a decrease in wound area, induction of granulation tissue, and reduction in bacterial colonization...
August 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27506662/impact-of-flap-reconstruction-on-radiotoxicity-after-salvage-surgery-and-reirradiation-for-recurrent-head-and-neck-cancer
#14
Allen S Ho, Zachary S Zumsteg, Annika Meyer, Nadeem Riaz, Rahmatullah Rahmati, Dennis H Kraus, Colleen McCarthy, Richard J Wong, Jatin P Shah, Nancy Y Lee
BACKGROUND: Recurrent head and neck malignancies remain a therapeutic challenge. Tissue transfer, in addition to defect coverage and prevention of wound complications, may potentially decrease radiotoxicity. We evaluated radiation toxicity and survival outcomes of patients who underwent salvage surgery with reirradiation, comparing primary closure to flap reconstruction. METHODS: Retrospective outcomes analysis of recurrent head and neck squamous cell carcinoma (HNSCC) patients treated with curative intent by salvage surgery (± flap reconstruction) and reirradiation from 1996 to 2011...
December 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27410466/a-single-centre-retrospective-study-of-cryopreserved-umbilical-cord-amniotic-membrane-tissue-for-the-treatment-of-diabetic-foot-ulcers
#15
A Raphael
OBJECTIVE: Histopathological studies have shown a prolonged inflammatory phase in wounds of patients with diabetes, delaying formation of mature granulation tissue and reducing wound tensile strength, making these wounds difficult for physicians to heal. Cryopreserved human umbilical cord (cUC) tissues possess unique anti-inflammatory and anti-scarring properties and have been found to help improve closure of these chronic wounds. METHOD: A retrospective chart review was performed to assess the efficacy of cUC as an advanced treatment modality to help promote the closure of chronic DFUs...
July 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27328431/engineered-human-vascularized-constructs-accelerate-diabetic-wound-healing
#16
Yu-I Shen, Hongkwan Cho, Arianne E Papa, Jacqueline A Burke, Xin Yi Chan, Elia J Duh, Sharon Gerecht
Stem cell-based therapy is emerging as a promising approach for chronic diabetic wounds, but strategies for optimizing both cellular differentiation and delivery remain as major obstacles. Here, we study bioengineered vascularized constructs as a therapeutic modality for diabetic wound healing. We developed a wound model in immunodeficient rodent and treated it with engineered vascularized constructs from endothelial progenitors or early vascular cells-derived from human induced pluripotent stem cells (hiPSCs) reprogrammed either from healthy donor or type-1 diabetic patient...
September 2016: Biomaterials
https://www.readbyqxmd.com/read/27185033/epidermal-grafting-versus-split-thickness-skin-grafting-for-wound-healing-epigraaft-study-protocol-for-a-randomised-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Muholan Kanapathy, Nadine Hachach-Haram, Nicola Bystrzonowski, Keith Harding, Afshin Mosahebi, Toby Richards
BACKGROUND: Split-thickness skin grafting (SSG) is an important modality for wound closure. However, the donor site becomes a second, often painful wound, which may take more time to heal than the graft site itself and holds the risk of infection and scarring. Epidermal grafting (EG) is an alternative method of autologous skin grafting that harvests only the epidermal layer of the skin by applying continuous negative pressure on the normal skin to raise blisters. This procedure has minimal donor site morbidity and is relatively pain-free, allowing autologous skin grafting in an outpatient setting...
May 17, 2016: Trials
https://www.readbyqxmd.com/read/27121406/systematic-and-specific-treatment-of-patients-with-enteroatmospheric-fistulas-from-initial-conservative-treatment-to-definitive-surgery
#18
COMPARATIVE STUDY
Daniel E Wainstein, Pablo Sisco, María L Deforel, Mariano Irigoyen, Jorge Devoto, Juan M Zarate
INTRODUCTION: The open abdomen is a widespread therapeutic resource; however, it is also a source of complications, of which the enteroatmospheric fistulas (EAFs) pose one of the greatest problems. The objective of this study was to describe the implemented strategy for handling enteroatmospheric fistulas, and secondarily, to analyze the differential results based on a change in the conservative local treatment specifically designed for the stated complication. MATERIALS AND METHODS: From March 2002 to March 2014, patients treated for EAF were retrospectively analyzed...
April 2016: Surgical Technology International
https://www.readbyqxmd.com/read/27081708/esophageal-perforation-after-anterior-cervical-spine-surgery-a-systematic-review-of-the-literature
#19
REVIEW
Sameer H Halani, Griffin R Baum, Jonathan P Riley, Gustavo Pradilla, Daniel Refai, Gerald E Rodts, Faiz U Ahmad
OBJECTIVE Esophageal perforation is a rare but well-known complication of anterior cervical spine surgery. The authors performed a systematic review of the literature to evaluate symptomatology, direct causes, repair methods, and associated complications of esophageal injury. METHODS A PubMed search that adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines included relevant clinical studies and case reports (articles written in the English language that included humans as subjects) that reported patients who underwent anterior spinal surgery and sustained some form of esophageal perforation...
September 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27054636/staged-repair-of-severe-open-abdomens-due-to-high-energy-gunshot-injuries-with-early-vacuum-pack-and-delayed-tissue-expansion-and-dual-sided-meshes
#20
Doğan Alhan, İsmail Şahin, Serbülent Güzey, Andaç Aykan, Fatih Zor, Serdar Öztürk, Mustafa Nışancı, İsmail Hakkı Özerhan
BACKGROUND: Open abdomen is a salvage procedure that prevents catastrophes after severe intraabdominal traumas. However, following this life saving attempt, it is mostly not feasible to close the abdomen immediately after the recovery of intraabdominal injuries. Consequently, a staged reconstruction is required, and the first stage is usually a temporary closing approach. At the end of this stage, resulting giant "ventral hernia" is a burden for both the patient and the surgeon. Therefore a permanent repair is subsequently needed...
December 2015: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
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