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JOURNAL ARTICLE
Hussein A Hammadi, Woruod Ahmed Hameed, Mohammed A Fakhri, Hussein M Khazaal, Fatima Kareem Abood, Ekhlas Khalid Hameed, Laith Thamer Al-Ameri
BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disease that is linked to several motor and nonmotor symptoms, including sleep disturbances. Patient quality of life has been shown to be disproportionally impacted by disease. OBJECTIVES: To investigate sleep quality among individuals with PD, and to assess the severity of sleep disturbances and their impact on daytime activities. SUBJECTS AND METHODS: A case‒control with 44 patients with Parkinson's disease and 80 apparently healthy control participants was recruited from several hospitals and clinics...
April 16, 2024: Irish Journal of Medical Science
#22
JOURNAL ARTICLE
Akash Goyal, Christopher D Crabtree, Bryan C Lee, Thura T Harfi, Saurabh Rajpal, Vedat O Yildiz, Orlando P Simonetti, Matthew S Tong
This study sought to evaluate the impact of severe obesity on image quality and ventricular function assessment in cardiovascular magnetic resonance (MRI) and trans-thoracic echocardiography (TTE). We studied 100 consecutive patients who underwent clinically indicated cardiac MRI and TTE studies within 12 months between July 2017 and December 2020; 50 (28 females and 22 males; 54.5 ± 18.7 years) with normal body mass index (BMI) (18.5-25 kg/m2 ) and 50 (21 females and 29 males; 47...
April 16, 2024: International Journal of Cardiovascular Imaging
#23
JOURNAL ARTICLE
S-A Safi, A Alexander, W Neuhuber, L Haeberle, A Rehders, T Luedde, I Esposito, G Fluegen, W T Knoefel
BACKGROUND: The implementation of the pathologic CRM (circumferential resection margin) staging system for pancreatic head ductal adenocarcinomas (hPDAC) resulted in a dramatic increase of R1 resections at the dorsal resection margin, presumably because of the high rate of mesopancreatic fat (MP) infiltration. Therefore, mesopancreatic excision (MPE) during pancreatoduodenectomy has recently been promoted and has demonstrated better local disease control, fueling the discussion of neoadjuvant downsizing regimes in MP + patients...
April 16, 2024: Langenbeck's Archives of Surgery
#24
JOURNAL ARTICLE
Gulcin Ozkara, Ezgi Irmak Aslan, Fidan Malikova, Cagatay Aydogan, Ozgur Selim Ser, Onur Kilicarslan, Sadiye Nur Dalgic, Ahmet Yildiz, Oguz Ozturk, Hulya Yilmaz-Aydogan
Coronary artery ectasia (CAE), defined as a 1.5-fold or greater enlargement of a coronary artery segment compared to the adjacent normal coronary artery, is frequently associated with atherosclerotic coronary artery disease (CAD). Membrane-bound endothelin converting enzyme-1 (ECE-1) is involved in the maturation process of the most potent vasoconstrictor ET-1. Polymorphisms in the endothelin (ET) gene family have been shown associated with the development of atherosclerosis. This study aims to investigate the effects of rs213045 and rs2038089 polymorphisms in the ECE-1 gene which have been previously shown to be associated with atherosclerosis and hypertension (HT), in CAE patients...
April 16, 2024: Biochemical Genetics
#25
JOURNAL ARTICLE
Batoul Alipour, Mohamad Zaman Kassaee
CONTEXT: Herein, we compare and contrast the dual roles of Cun clusters (n = 3, 5, and 7 atoms) in scavenging or generating RO• free radicals from ROH at the theoretical levels (where R = H, methyl, ethyl, n-propyl, i-propyl, n-butyl, t-butyl, and phenyl). This investigation is performed in water media to mimic the actual environment in the biological system. In the presence of the Cun clusters, bond dissociation energy (BDE) of RO-H and R-OH is reduced...
April 16, 2024: Journal of Molecular Modeling
#26
JOURNAL ARTICLE
Gavin J Smith, Spyridon Koutsoukos, Ben Lancaster, Julian Becker, Tom Welton, Patricia A Hunt
The impact of ionic liquids (ILs) on polar reactions is well recognised, however the impact of ILs on non-polar reactions is less well understood or explored. Pericyclic Cope rearrangements are highly concerted, exhibit minimal charge localisation and pass through an uncharged but well-defined transition state, and thus provide a good mechanism for exploring the impact of IL polarizability on chemical reactivity. Recently, a 10× rate enhancement has been observed for the Cope rearrangement of 3-phenyl-1,5-hexadiene in the IL 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide [C4 C1 im][NTf2 ] compared to benzene...
April 16, 2024: Physical Chemistry Chemical Physics: PCCP
#27
JOURNAL ARTICLE
Flavia Palombo, Alessandro Vaisfeld, Valentina Concetta Tropeano, Danara Ormanbekova, Isabelle Bacchi, Claudio Fiorini, Adelaide Peruzzi, Luca Morandi, Rocco Liguori, Valerio Carelli, Giovanni Rizzo
The reduced penetrance of TBP intermediate alleles and the recently proposed possible digenic TBP/STUB1 inheritance raised questions on the possible mechanism involved opening a debate on the existence of SCA48 as a monogenic disorder. We here report clinical and genetic results of two apparently unrelated patients carrying the same STUB1 variant(c.244G > T;p.Asp82Tyr) with normal TBP alleles and a clinical picture fully resembling SCA48, including cerebellar ataxia, dysarthria and mild cognitive impairment...
April 16, 2024: Neurogenetics
#28
JOURNAL ARTICLE
Lourdes M DelRosso, David Panek, Erin Mackintosh, Klane White, Greg Redding
PURPOSE: Patients with early onset scoliosis are at high risk of sleep disordered breathing, sleep disruption, and adverse consequences of poor sleep. In this study, we aim to assess the prevalence of periodic limb movements of sleep in a cohort of children with early onset scoliosis and identify factors that correlate with the presence of periodic limb movements. METHODS: This is a retrospective chart review of 40 patients with EOS (ages 1-17 years) who underwent a PSG from 2003 through 2019...
April 16, 2024: Sleep & Breathing
#29
JOURNAL ARTICLE
Marscha M Engelen, Marie-Christine J P Franken, Lottie W Stipdonk, Sarah E Horton, Victoria E Jackson, Sheena Reilly, Angela T Morgan, Simon E Fisher, Sandra van Dulmen, Else Eising
PURPOSE: Stuttering is a speech condition that can have a major impact on a person's quality of life. This descriptive study aimed to identify subgroups of people who stutter (PWS) based on stuttering burden and to investigate differences between these subgroups on psychosocial aspects of life. METHOD: The study included 618 adult participants who stutter. They completed a detailed survey examining stuttering symptomatology, impact of stuttering on anxiety, education and employment, experience of stuttering, and levels of depression, anxiety, and stress...
April 16, 2024: Journal of Speech, Language, and Hearing Research: JSLHR
#30
JOURNAL ARTICLE
Kate A Gibson, Diana Luong, Paul G Isaac, Lars Schumacher, Rainer Pöttgen, Boniface P T Fokwa
The metal borides, Hf2 MOs5 B2 (M = Mn, Fe, Co), which are the first Os-rich quaternary variants of the prolific Ti3 Co5 B2 structure type, were investigated computationally and experimentally. In their crystal structures, osmium builds a network of prisms, in which the other elements are located. The magnetic M elements are found in face-connected Os8 square prisms leading to M-chains with intra- and interchain distances of about 3.0 and 6.5 Å, respectively. Density functional theory (DFT) showed that magnetic ordering is hugely favored for M = Mn and Fe but only slightly favored for M = Co...
April 16, 2024: Inorganic Chemistry
#31
JOURNAL ARTICLE
Hannah W Song, Michaela Prochazkova, Lipei Shao, Roshini Traynor, Sarah Underwood, Mary Black, Vicki Fellowes, Rongye Shi, Marie Pouzolles, Hsien-Chao Chou, Adam T Cheuk, Naomi Taylor, Ping Jin, Robert P Somerville, David F Stroncek, Javed Khan, Steven L Highfill
With investigators looking to expand engineered T cell therapies such as CAR-T to new tumor targets and patient populations, a variety of cell manufacturing platforms have been developed to scale manufacturing capacity using closed and/or automated systems. Such platforms are particularly useful for solid tumor targets, which typically require higher CAR-T cell doses. Although T cell phenotype and function are key attributes that often correlate with therapeutic efficacy, how manufacturing platforms influence the final CAR-T cell product is currently unknown...
March 12, 2024: Cytotherapy
#32
JOURNAL ARTICLE
Anthony D Jimenez, Margaret Gopaul, Hannah Asbell, Seyhmus Aydemir, Maysaa M Basha, Ayush Batra, Charlotte Damien, Gregory S Day, Onome Eka, Krista Eschbach, Safoora Fatima, Madeline C Fields, Brandon Foreman, Elizabeth E Gerard, Teneille E Gofton, Hiba A Haider, Stephen T Hantus, Sara Hocker, Amy Jongeling, Mariel Kalkach Aparicio, Padmaja Kandula, Peter Kang, Karnig Kazazian, Marissa A Kellogg, Minjee Kim, Jong Woo Lee, Lara V Marcuse, Christopher M McGraw, Wazim Mohamed, Janet Orozco, Cederic Pimentel, Vineet Punia, Alexandra M Ramirez, Claude Steriade, Aaron F Struck, Olga Taraschenko, Andrew K Treister, Ji Yeoun Yoo, Sahar Zafar, Daniel J Zhou, Deepti Zutshi, Nicolas Gaspard, Lawrence J Hirsch, Aurelie Hanin
Febrile infection-related epilepsy syndrome (FIRES) is a subset of new onset refractory status epilepticus (NORSE) that involves a febrile infection prior to the onset of the refractory status epilepticus. It is unclear whether FIRES and non-FIRES NORSE are distinct conditions. Here, we compare 34 patients with FIRES to 30 patients with non-FIRES NORSE for demographics, clinical features, neuroimaging, and outcomes. Because patients with FIRES were younger than patients with non-FIRES NORSE (median = 28 vs...
April 16, 2024: Epilepsia
#33
JOURNAL ARTICLE
Roman Johannes Gertz, Thomas Dratsch, Alexander Christian Bunck, Simon Lennartz, Andra-Iza Iuga, Martin Gunnar Hellmich, Thorsten Persigehl, Lenhard Pennig, Carsten Herbert Gietzen, Philipp Fervers, David Maintz, Robert Hahnfeldt, Jonathan Kottlors
Background Errors in radiology reports may occur because of resident-to-attending discrepancies, speech recognition inaccuracies, and large workload. Large language models, such as GPT-4 (ChatGPT; OpenAI), may assist in generating reports. Purpose To assess effectiveness of GPT-4 in identifying common errors in radiology reports, focusing on performance, time, and cost-efficiency. Materials and Methods In this retrospective study, 200 radiology reports (radiography and cross-sectional imaging [CT and MRI]) were compiled between June 2023 and December 2023 at one institution...
April 2024: Radiology
#34
JOURNAL ARTICLE
Sunny Gupta, Rashima Prem, Chinmayee Sethy, Saurabh Shrivastava, Manju Singh, Pramod Yadav, V G Huddar, P K Prajapati, Anita Roy, Monica Sundd, Ashok Kumar Patel
Plants have a history of being employed in managing breast cancer. However, no scientific evidence supports the idea that these plants can effectively reduce the level of HER2 expression. In this study, extracts from 10 medicinal plants were evaluated for their anticancer properties against HER2-positive breast cancer cells through various methods, including the SRB assay, comet assay, annexin V-FITC dual staining, and immunoblotting. All extracts exerted antiproliferative activity against HER2-positive breast cancer cells...
April 16, 2024: Journal of Agricultural and Food Chemistry
#35
JOURNAL ARTICLE
Halie Rando, Emmarie P Alexander, Sophie Preckler-Quisquater, Cate B Quinn, Jeremy T Stutchman, Jennifer L Johnson, Estelle R Bastounes, Beata Horecka, Kristina L Black, Michael P Robson, Darya V Shepeleva, Yury E Herbeck, Anastasiya V Kharlamova, Lyudmila N Trut, Jonathan N Pauli, Benjamin N Sacks, Anna V Kukekova
The first record of captive bred red foxes (Vulpes vulpes) dates to 1896, when a breeding enterprise emerged in the provinces of Atlantic Canada. Because its domestication happened during recent history, the red fox offers a unique opportunity to examine the genetic diversity of an emerging domesticated species in the context of documented historical and economic influences. In particular, the historical record suggests that North American and Eurasian farm-bred populations likely experienced different demographic trajectories...
April 16, 2024: Journal of Heredity
#36
JOURNAL ARTICLE
Hongye Li, Jingyu Tan, Song Yang, Yapeng Sun, Huangzhong Yu
Two-dimensional (2D) materials have attracted attention due to their excellent optoelectronic properties, but their applications are limited by their defects and vacancies. Surface modification is an effective method to restore their performance. Here, ZrSe2 is modified with conductive polymer p -toluenesulfonic acid (PTSA). It is found that PTSA can obtain electrons of ZrSe2 through the combination of -SO3 H and ZrSe2 , thus forming interfacial dipoles, which improve the work function of ZrSe2 . In addition, -OH in PTSA can effectively fill the Se vacancy in ZrSe2 to form P-type doping, thereby improving its conductivity...
April 16, 2024: ACS Applied Materials & Interfaces
#37
JOURNAL ARTICLE
Yevgenia Rosenblum, Mariana Pereira, Oliver Stange, Frederik D Weber, Leonore Bovy, Sofia Tzioridou, Elisa Lancini, David A Neville, Nadja Klein, Timo de Wolff, Mandy Stritzke, Iris Kersten, Manfred Uhr, Jurgen A H R Claassen, Axel Steiger, Marcel M Verbeek, Martin Dresler
OBJECTIVE: Recent evidence shows that during slow-wave sleep (SWS), the brain is cleared from potentially toxic metabolites, such as the amyloid-beta protein. Poor sleep or elevated cortisol levels can worsen amyloid-beta clearance, potentially leading to the formation of amyloid plaques, a neuropathological hallmark of Alzheimer disease. Here, we explored how nocturnal neural and endocrine activity affects amyloid-beta fluctuations in the peripheral blood. METHODS: We acquired simultaneous polysomnography and all-night blood sampling in 60 healthy volunteers aged 20-68 years...
April 16, 2024: Annals of Neurology
#38
JOURNAL ARTICLE
Reyhan Koroglu, Mustafa Koroglu, Hatice Aygun
AIM: We aimed to investigate the possible cardioprotective effects of paricalcitol (PR), its vitamin D receptor agonist, and vitamin D3 (VIT-D3) on an experimental model of doxorubicin (DX) cardiotoxicity by 99mTc-PYP scintigraphy, electrocardiographic (ECG) and biochemical methods. METHOD: Forty-two male Wistar/Albino rats (250‒300 g; aged 10‒12 weeks) were randomly separated into six groups, namely into control (CN), doxorubicin (DX), paricalcitol (PR), vitamin D3 (VIT-D3), paricalcitol + doxorubicin (PR+DX), and vitamin D3 + doxorubicin (VIT-D3+DX) groups...
2024: Bratislavské Lekárske Listy
#39
JOURNAL ARTICLE
Jameel Abuljadayel, Hassan Abed
PURPOSE: This cross-sectional study aimed to evaluate and predict variables that influence the Students' Course Evaluation Surveys (SCES) in a bachelor's degree of dental medicine and surgery program. MATERIALS AND METHODS: Data from the Faculty of Dental Medicine for the academic year 2021-2022 were analyzed including 39 course reports, students' course evaluation surveys, students' academic performance data, and the program specification. The survey contains 24 statements that evaluate five main domains of the courses, which are course syllabus, staff performance through the course, course learning resources, course execution, and course quality...
April 16, 2024: Journal of Dental Education
#40
JOURNAL ARTICLE
Brian T Fisher, Jesse Blumenstock, Craig L K Boge, Sydney Shuster, Alix E Seif, Michael Green, Marian G Michaels, Jessie L Alexander, Monica I Ardura, Tamara P Miller, Diego R Hijano, William J Muller, Jennifer E Schuster, Abby M Green, Daniel E Dulek, Adriana E Kajon, Lara Danziger-Isakov
BACKGROUND: Pediatric allogeneic hematopoietic cell transplant (allo-HCT) recipients are at risk for morbidity and mortality from human adenovirus (HAdV). HAdV can be detected in an asymptomatic state, referred to as infection or with signs or symptoms of illness, referred to as disease. Standardized case definitions are needed to distinguish infection from disease and allow for consistent reporting in both observational cohort studies and therapeutic clinical trials. METHODS: A working group of experts in virology, transplant infectious disease, and HCT was assembled to develop HAdV infection and disease definitions with the degree of certainty (i...
May 2024: Pediatric Transplantation
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