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https://www.readbyqxmd.com/read/29909586/fractal-dimension-brain-morphometry-a-novel-approach-to-quantify-white-matter-in-traumatic-brain-injury
#1
Venkateswaran Rajagopalan, Abhijit Das, Luduan Zhang, Frank Hillary, Glenn R Wylie, Guang H Yue
Traumatic brain injury (TBI) is the main cause of disability in people younger than 35 in the United States. The mechanisms of TBI are complex resulting in both focal and diffuse brain damage. Fractal dimension (FD) is a measure that can characterize morphometric complexity and variability of brain structure especially white matter (WM) structure and may provide novel insights into the injuries evident following TBI. FD-based brain morphometry may provide information on WM structural changes after TBI that is more sensitive to subtle structural changes post injury compared to conventional MRI measurements...
June 16, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29909470/risk-of-fracture-and-low-bone-mineral-density-in-adults-with-inflammatory-bowel-diseases-a-systematic-literature-review-with-meta-analysis
#2
REVIEW
P Szafors, H Che, T Barnetche, J Morel, C Gaujoux-Viala, B Combe, C Lukas
Inflammatory bowel diseases (IBDs) are associated with a decreased bone mineral density, but the impact on fractures is unknown. In our study, global risk of fracture is increased for patients with IBDs versus controls. This result will help to determine the appropriate assessment with early screening and management of osteoporosis. Inflammatory bowel diseases (IBDs), such as Crohn's disease (CD) and ulcerative colitis (UC), are associated with a decreased bone mineral density (BMD). However, the impact on fracture risk is unknown and data are contradictory across studies...
June 16, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29909432/pharmacokinetics-of-a-novel-sildenafil-orodispersible-film-administered-by-the-supralingual-and-the-sublingual-route-to-healthy-men
#3
Luca Loprete, Chiara Leuratti, Valeria Frangione, Milko Radicioni
BACKGROUND: Sildenafil was the first selective drug available on the market as oral therapy for erectile dysfunction (ED). A novel sildenafil orodispersible film (ODF) for ED treatment, containing sildenafil citrate, has recently been marketed. OBJECTIVES: Study objective was to investigate sildenafil bioavailability of the novel ODF formulation after sublingual and supralingual administration. METHODS: In this randomised, two-way cross-over study, 12 healthy male volunteers received a single 50 mg sildenafil dose by the sublingual and supralingual administration routes...
June 16, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29909409/the-possible-role-of-gene-variant-coding-nonfunctional-toll-like-receptor-2-in-the-pathogenesis-of-mastocytosis
#4
Bogusław Nedoszytko, Magdalena Lange, Joanna Renke, Marek Niedoszytko, Monika Zabłotna, Jolanta Gleń, Roman Nowicki
BACKGROUND: Data on the genetic predisposition to mastocytosis are scarce. The aim of this work was to study the association of single nucleotide polymorphisms of Toll-like receptor (TLR)-2, TLR-4, and TLR-9 genes in Polish patients with mastocytosis. OBJECTIVES: The study comprised 137 patients with mastocytosis (102 cutaneous [60 children and 42 adults] and 35 systemic cases); 171 disease-free individuals were used as controls. METHOD: The frequency of polymorphisms R753Q (rs5743708) of TLR-2, 896 A>G (rs496790) of TLR-4, and -1237C>T (rs5743836) of TLR-9 genes were determined with the use of the amplification refractory mutation system polymerase chain reaction method...
June 15, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29909380/schwannomatosis-a-genetic-and-epidemiological-study
#5
D Gareth Evans, Naomi L Bowers, Simon Tobi, Claire Hartley, Andrew J Wallace, Andrew T King, Simon K W Lloyd, Scott A Rutherford, Charlotte Hammerbeck-Ward, Omar N Pathmanaban, Simon R Freeman, John Ealing, Mark Kellett, Roger Laitt, Owen Thomas, Dorothy Halliday, Rosalie Ferner, Amy Taylor, Chris Duff, Elaine F Harkness, Miriam J Smith
OBJECTIVES: Schwannomatosis is a dominantly inherited condition predisposing to schwannomas of mainly spinal and peripheral nerves with some diagnostic overlap with neurofibromatosis-2 (NF2), but the underlying epidemiology is poorly understood. We present the birth incidence and prevalence allowing for overlap with NF2. METHODS: Schwannomatosis and NF2 cases were ascertained from the Manchester region of England (population=4.8 million) and from across the UK. Point prevalence and birth incidence were calculated from regional birth statistics...
June 16, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29909352/the-role-of-milk-fat-globule-membranes-in-behavior-and-cognitive-function-using-a-suckling-rat-pup-supplementation-model
#6
Lauren R Brink, Bo Lönnerdal
Milk fat globule membranes (MFGM) surround droplets delivering lipids to the breast-fed infant and are enriched with glycoproteins upon exocytosis out of the mammary cell. MFGM is typically removed during processing of cow milk for the manufacture of infant formula. Recent clinical trials have found that formula supplemented with bovine MFGM improved cognition. Here, we aimed to explore the mechanisms behind this improved developmental outcome. Sprague-Dawley rats were bred, and their litters were manipulated to either 10 pups to represent normal growth (N) or 16 pups to represent restricted growth (R) per dam...
May 21, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29909314/anorectic-responses-to-t-2-toxin-ht-2-toxin-diacetoxyscirpenol-and-neosolaniol-correspond-to-plasma-elevations-of-neurotransmitters-5-hydroxytryptamine-and-substance-p
#7
Jie Zhang, Kun Sheng, Wenda Wu, Haibin Zhang
Trichothecene mycotoxins commonly contaminate cereal grains and are often linked to human and animal food poisoning. The rapid onset of anorexia is a common hallmark of trichothecenes-induced toxicity. Although the neurotransmitters 5-hydroxytryptamine (5-HT) and substance P (SP) are known to regulate appetite, it remains unknown whether these two neurotransmitters are involved in type A trichothecenes-induced anorectic response. The goal of this study is to relate plasma 5-HT and SP to anorectic responses induced by type A trichothecenes T-2 toxin (T-2), HT-2 toxin (HT-2), diacetoxyscirpenol (DAS) and neosolaniol (NEO)...
June 13, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29909304/prevalence-and-predictors-of-violent-victimization-in-remitted-patients-with-recurrent-depression
#8
C Christ, M de Jonge, C L H Bockting, M J Kikkert, D J F van Schaik, A T F Beekman, J J M Dekker
BACKGROUND: Depressed patients are at increased risk to fall victim to a violent crime compared to the general population. It remains unknown whether their increased risk persists after remission. This study compared victimization rates of remitted patients with both a random general population sample and a group of currently depressed patients. Furthermore, this study aimed to identify predictors of future violent victimization. METHODS: In this longitudinal study conducted in the Netherlands, 12-month prevalence rates of sexual assaults, physical assaults, and threats were assessed with the Safety Monitor in 140 currently remitted patients with recurrent depression, and compared to those of a weighted general population sample (N = 9...
June 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29909185/accuracy-of-smartphone-based-evaluation-of-emergent-large-vessel-occlusion-on-cta
#9
Douglas T Hidlay, Ryan A McTaggart, Grayson Baird, Shadi Yaghi, Morgan Hemendinger, Eric L Tung, Eleanor L Dibiasio, Richard A Haas, Mahesh V Jayaraman
OBJECTIVES: Mechanical thrombectomy is the standard of care for stroke caused by an emergent large vessel occlusion in the anterior circulation, and the ability to rapidly review CTA is one hurdle in minimizing the time from diagnosis to intervention. We evaluated the diagnostic accuracy and confidence in review of stroke CTA for ELVO via a smartphone-based application as compared to PACS workstation. PATIENTS AND METHODS: Seventy-six head and neck CTA studies performed for stroke from one comprehensive and seven primary stroke centers were independently reviewed remotely on smartphone by two blinded interventional neuroradiologists in actual-use circumstances...
June 11, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29909152/early-fever-after-haploidentical-bmt-correlates-with-class-ii-hla-mismatching-and-myeloablation-but-not-outcomes
#10
Shannon R McCurdy, Stephen T Muth, Hua-Ling Tsai, Heather J Symons, Carol Ann Huff, William H Matsui, Ivan Borrello, Douglas E Gladstone, Lode J Swinnen, Kenneth R Cooke, Robert A Brodksy, Javier Bolaños-Meade, Richard F Ambinder, Ravi Varadhan, Leo Luznik, Rick J Jones, Maria P Bettinotti, Ephraim J Fuchs
Non-infectious fevers are common early after T-cell replete HLA-haploidentical (haplo) peripheral blood transplants and have been associated with cytokine release syndrome and overall mortality. However, less is known regarding the incidence and associations of early fever after bone marrow transplantation (BMT) with post-transplant cyclophosphamide (PTCy). We hypothesized that early fever would be associated with myeloablative conditioning (MAC), because of its relative increase in tissue damage augmenting antigen-presentation, and Class II HLA-mismatching, due recognition of antigen-presenting cells by CD4+ T-cells...
June 15, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29909110/comprehensive-echocardiographic-assessment-of-normal-transcatheter-valve-function
#11
Rebecca T Hahn, Jonathon Leipsic, Pamela S Douglas, Wael A Jaber, Neil J Weissman, Philippe Pibarot, Philipp Blanke, Jae K Oh
OBJECTIVES: This study aims to establish parameters for identifying normal function for each of the 3 iterations of balloon-expandable valves and 2 iterations of self-expanding valves. BACKGROUND: Expected transthoracic echocardiographic Doppler-derived hemodynamic data for transcatheter aortic valves inform pre-implant decision-making and post-implanted monitoring of longitudinal valve function. METHODS: We collected the Echocardiography Core Lab measured mean gradients and effective orifice area (EOA) from discharge or 30-day echocardiograms from randomized trials; the PARTNER (Placement of Aortic Transcatheter Valves) trials for the balloon-expandable valves and the Medtronic CoreValve US Pivotal trial and Medtronic CoreValve Evolut R United States IDE Clinical Study for the self-expanding valves...
June 8, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29909084/clinical-outcomes-in-the-treatment-of-unilateral-condylar-fractures-a-cross-sectional-study
#12
A V J Rozeboom, L T Klumpert, M Koutris, L Dubois, C M Speksnijder, F Lobbezoo, J de Lange
The treatment of mandibular condyle fractures has been the subject of considerable discussion, especially whether open or closed treatment should be used. There is a need for practical,evidence-based guidelines, and both objective and subjective parameters should be measured. To date, fewstudies have considered clinically relevant subjective parameters. This study was performed to evaluate the outcomes of the treatment of condylar fractures using the Mandibular Function Impairment Questionnaire (MFIQ) and the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) and to compare the outcomes of open and the closed treatment...
June 13, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29909005/accuracy-of-sensititre-yeastone-echinocandins-epidemiological-cut-off-values-for-identification-of-fks-mutant-candida-albicans-and-candida-glabrata-a-ten-year-national-survey-of-the-fungal-infection-network-of-switzerland-funginos
#13
A Kritikos, D Neofytos, N Khanna, P W Schreiber, K Boggian, J Bille, J Schrenzel, K Mühlethaler, R Zbinden, T Bruderer, D Goldenberger, G Pfyffer, A Conen, C Van Delden, S Zimmerli, D Sanglard, D Bachmann, O Marchetti, F Lamoth
OBJECTIVES: Echinocandins represent the first-line treatment of candidemia. Acquired echinocandin resistance is mainly observed among Candida albicans and glabrata and is associated with FKS hotspot mutations. The commercial Sensititre YeastOneTM (SYO) kit is widely used for antifungal susceptibility testing, but interpretive clinical breakpoints are not well defined. We determined echinocandins epidemiological cut-off values (ECV) for C. albicans/glabrata tested by SYO and assessed their ability to identify FKS mutants in a national survey of candidemia...
June 14, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29908978/feasibility-of-intravoxel-incoherent-motion-for-differentiating-benign-and-malignant-thyroid-nodules
#14
Hui Tan, Jun Chen, Yi Ling Zhao, Jin Huan Liu, Liang Zhang, Chang Sheng Liu, Dongjie Huang
RATIONALE AND OBJECTIVES: This study aimed to preliminarily investigate the feasibility of intravoxel incoherent motion (IVIM) theory in the differential diagnosis of benign and malignant thyroid nodules. MATERIALS AND METHODS: Forty-five patients with 56 confirmed thyroid nodules underwent preoperative routine magnetic resonance imaging and IVIM diffusion-weighted imaging. The histopathologic diagnosis was confirmed by surgery. Apparent diffusion coefficient (ADC), perfusion fraction f, diffusivity D, and pseudo-diffusivity D* were quantified...
June 13, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29908955/novel-epitopes-identified-from-mycobacterium-tuberculosis-antigen-rv2629induces-cytotoxic-t-lymphocyte-response
#15
Bai Xuejuan, Wang Dongfang, Yinping Liu, Xiao Li, Yan Liang, Yourong Yang, Junxian Zhang, Minggui Lin, Wu Xueqiong
There is an urgent need for a more effective vaccine against tuberculosis (TB). Cytotoxic T lymphocytes (CTLs) play a critical role in combating Mycobacterium tuberculosis (M.tb). The identification of novel CTL epitopes is essential for the design of peptide-based vaccines. In this study, we predicted CTL epitope peptides of M.tb antigen Rv2629 restricted by HLA-A2, using bioinformatics methods. The affinity and stability of binding of these peptides with HLA-A2 molecules were detected by flow cytometry. Their ability to induce CTLs generation was determined in peripheral blood mononuclear cells (PBMCs) from healthy uninfected subjects, Latent tuberculosis infection (LTBI) subjects, and TB patients ex vivo...
June 14, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29908950/low-transcriptional-activity-of-pon2-in-recurrent-abortion-a-novel-therapeutic-agent
#16
Levent Dikbas, Riza Dur, İsmail Hakkı Tas, Ömer Erkan Yapça, Neslihan Dikbas
OBJECTIVE: Oxidative stress has been reported to be associated with various pregnancy complications and to play key roles in many of them. An inadequate level of antioxidant defense may eventually lead to an early pregnancy loss. There is a lack of information about the roles of the PON2 and PON3 enzymes in the etiology of the cases of unexplained recurrent abortus. The aim of our study is to determine and present the data regarding the roles of these enzymes for the first time. MATERIALS AND METHODS: We measured the transcriptional levels of the PON2 and PON3 enzymes in the curettage materials obtained from the patients with unexplained recurrent abortus (n=25) and compared the results with those measured in the abortus materials from healthy pregnant women (n=50) who had undergone a voluntary abortion...
June 14, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29908884/influence-of-aflibercept-on-platelet-activation-profile
#17
B Sobolewska, J Golenko, S Poeschel, C Grimmel, A Gatsiou, K Sopova, T Biedermann, K Schenke-Layland, K Stellos, F Ziemssen
Aflibercept appears to accumulate in systemic circulation following intravitreal injections in therapy of neovascular age-related macular degeneration. This gives raise to the question of whether aflibercept affects platelets and their function such as activation and aggregation, which are substantial in the pathogenesis of an arterial thromboembolic event (ATE). In order to determine the effect of aflibercept in platelet activation, platelets from healthy volunteers were treated with aflibercept and its solvents at equal concentrations (0...
June 14, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29908878/marked-prognostic-impact-of-minimal-lymphatic-tumor-spread-in-prostate-cancer
#18
Waldemar Wilczak, Corinna Wittmer, Till Clauditz, Sarah Minner, Stefan Steurer, Franziska Büscheck, Till Krech, Maximilian Lennartz, Luisa Harms, Diane Leleu, Marc Ahrens, Sebastian Ingwerth, Christian T Günther, Christina Koop, Ronald Simon, Frank Jacobsen, Maria C Tsourlakis, Viktoria Chirico, Doris Höflmayer, Eik Vettorazzi, Alexander Haese, Thomas Steuber, Georg Salomon, Uwe Michl, Lars Budäus, Derya Tilki, Imke Thederan, Christoph Fraune, Cosima Göbel, Marie-Christine Henrich, Manuela Juhnke, Katharina Möller, Ahmed Abdullah Bawahab, Ria Uhlig, Meike Adam, Sören Weidemann, Burkhard Beyer, Hartwig Huland, Markus Graefen, Guido Sauter, Thorsten Schlomm
BACKGROUND: Nodal metastasis (N1) is a strong prognostic parameter in prostate cancer; however, lymph node evaluation is always incomplete. OBJECTIVE: To study the prognostic value of lymphatic invasion (L1) and whether it might complement or even replace lymph node analysis in clinical practice. DESIGN, SETTING, AND PARTICIPANTS: Retrospective analysis of pathological and clinical data from 14 528 consecutive patients. INTERVENTION: Radical prostatectomy...
June 13, 2018: European Urology
https://www.readbyqxmd.com/read/29908819/association-of-25-hydroxyvitamin-d-levels-and-cutaneous-melanoma-a-nested-case-control-study-of-the-women-s-health-initiative-observation-study
#19
Gina P Kwon, Christina S Gamba, Marcia L Stefanick, Susan M Swetter, Shufeng Li, Run Zhang Shi, Christina A Clarke, David Feldman, Amy E Millen, Catherine Messina, James M Shikany, JoAnn E Manson, Rowan T Chlebowski, Jean Y Tang
No abstract text is available yet for this article.
July 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29908813/the-influence-of-fat-and-hemicellulose-on-methane-production-and-energy-utilization-in-lactating-jersey-cattle
#20
O R Drehmel, T M Brown-Brandl, J V Judy, S C Fernando, P S Miller, K E Hales, P J Kononoff
Feeding fat to lactating dairy cows may reduce methane production. Relative to cellulose, fermentation of hemicellulose is believed to result in less methane; however, these factors have not been studied simultaneously. Eight multiparous, lactating Jersey cows averaging (±SD) 98 ± 30.8 d in milk and body weight of 439.3 ± 56.7 kg were used in a twice-replicated 4 × 4 Latin square to determine the effects of fat and hemicellulose on energy utilization and methane production using a headbox-type indirect calorimetry method...
June 13, 2018: Journal of Dairy Science
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