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https://www.readbyqxmd.com/read/29475126/snp-rs403212791-in-exon-2-of-the-mtnr1a-gene-is-associated-with-reproductive-seasonality-in-the-rasa-aragonesa-sheep-breed
#1
J H Calvo, M Serrano, A Martinez-Royo, B Lahoz, P Sarto, A Ibañez-Deler, J Folch, J L Alabart
The aim of this study was to characterize and identify causative SNPs in the MTNR1A gene responsible for the reproductive seasonality traits in the Rasa aragonesa sheep breed. A total of 290 ewes (155, 84 and 51 mature, young and ewe lambs, respectively) from one flock were controlled from January to August. The following three reproductive seasonality traits were considered: the total days of anoestrus (TDA) and the progesterone cycling months (P4CM); both ovarian function seasonality traits based on blood progesterone levels; and the oestrus cycling months (OCM) based on oestrous detection, which indicate behavioural signs of oestrous...
February 12, 2018: Theriogenology
https://www.readbyqxmd.com/read/29475092/the-impact-of-donor-characteristics-on-the-invariant-natural-killer-t-cells-of-granulocyte-colony-stimulating-factor-mobilized-marrow-grafts-and-peripheral-blood-grafts
#2
Hong Yan, Zhao Xiangyu, Yu Xingxing, Bian Zhilei, Chang Yingjun, Yu Wang, Zhang Xiaohui, Xu Lanping, Huang Xiaojun, Zhao Xiaosu
INTRODUCTION: Invariant natural killer T cells (iNKTs) are a rare but vital subset of immunomodulatory T cells and play an important role in allogeneic hematopoietic stem cell trans-plantation (HSCT). The association of donor characteristics with the number and frequency of the iNKTs subsets in allografts remains poorly understood. In this paper, we prospectively investigate the association of donor characteristics with iNKTs dose and frequency in granulocyte-colony-stimulating factor (G-CSF) mobilized marrow and peripheral blood harvests...
February 20, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29475073/development-and-preliminary-validation-of-the-parenting-around-snacking-questionnaire-p-snaq
#3
K K Davison, C E Blake, A Kachurak, J C Lumeng, D L Coffman, A L Miller, S O Hughes, T G Power, A F Vaughn, R E Blaine, N Younginer, J O Fisher
Snacking makes significant contributions to children's dietary intake but is poorly understood from a parenting perspective. This research was designed to develop and evaluate the psychometrics of a theoretically grounded, empirically-informed measure of snack parenting. The Parenting around SNAcking Questionnaire (P-SNAQ) was developed using a conceptual model derived from current theory and mixed-methods research to include 20 hypothesized snack parenting practices along 4 parenting dimensions (autonomy support, structure, coercive control and permissiveness)...
February 20, 2018: Appetite
https://www.readbyqxmd.com/read/29475059/ventro-lateral-motor-thalamus-abnormal-connectivity-in-essential-tremor-before-and-after-thalamotomy-a-resting-state-fmri-study
#4
Constantin Tuleasca, Elena Najdenovska, Jean Régis, Tatiana Witjas, Nadine Girard, Jérôme Champoudry, Mohamed Faouzi, Jean-Philippe Thiran, Meritxell Bach Cuadra, Marc Levivier, Dimitri Van De Ville
OBJECTIVE: To evaluate functional connectivity (FC) of the ventro-lateral thalamus, a common target for drug-resistant essential tremor (ET), resting-state data were analyzed before and 1 year after stereotactic radiosurgical thalamotomy (SRS-T), and compared against healthy controls (HC). METHODS: 17 consecutive patients and 10 HC were enrolled. Tremor network was investigated using ventro-lateral ventral (VLV) nucleus as region-of-interest (ROI), extracted using automated segmentation from pretherapeutic diffusion MRI...
February 20, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29475018/kynurenine-pathway-metabolism-and-the-neurobiology-of-treatment-resistant-depression-comparison-of-multiple-ketamine-infusions-and-electroconvulsive-therapy
#5
A P Allen, M Naughton, J Dowling, A Walsh, R O'Shea, G Shorten, L Scott, D M McLoughlin, J F Cryan, G Clarke, T G Dinan
Current first-line antidepressants can take weeks or months to decrease depressive symptoms. Low dose ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, shows potential for a more rapid antidepressant effect, with efficacy also evident in previously treatment-resistant populations. However, a greater understanding of the physiological mechanisms underlying such effects is required. We assessed the potential impact of ketamine infusion on neurobiological drivers of kynurenine pathway metabolism in major depression (HPA axis hyperactivity, inflammation) in patients with treatment-resistant depression compared to gender-matched healthy controls...
February 10, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29474990/estimation-of-stature-from-hand-and-foot-dimensions-in-a-korean-population
#6
Wonjoon Kim, Yong Min Kim, Myung Hwan Yun
The estimation of stature using foot and hand dimensions is essential in the process of personal identification. The shapes of feet and hands vary depending on races and gender, and it is of great importance to design an adequate equation in consideration of variances to estimate stature. This study is based on a total of 5,195 South Korean males and females, aged from 20 to 59 years. Body dimensions of stature, hand length, hand breadth, foot length, and foot breadth were measured according to standard anthropometric procedures...
February 13, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29474933/an-optimised-multi-arm-multi-stage-clinical-trial-design-for-unknown-variance
#7
Michael J Grayling, James M S Wason, Adrian P Mander
Multi-arm multi-stage trial designs can bring notable gains in efficiency to the drug development process. However, for normally distributed endpoints, the determination of a design typically depends on the assumption that the patient variance in response is known. In practice, this will not usually be the case. To allow for unknown variance, previous research explored the performance of t-test statistics, coupled with a quantile substitution procedure for modifying the stopping boundaries, at controlling the familywise error-rate to the nominal level...
February 20, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29474920/a-mild-pum1-mutation-is-associated-with-adult-onset-ataxia-whereas-haploinsufficiency-causes-developmental-delay-and-seizures
#8
Vincenzo A Gennarino, Elizabeth E Palmer, Laura M McDonell, Li Wang, Carolyn J Adamski, Amanda Koire, Lauren See, Chun-An Chen, Christian P Schaaf, Jill A Rosenfeld, Jessica A Panzer, Ute Moog, Shuang Hao, Ann Bye, Edwin P Kirk, Pawel Stankiewicz, Amy M Breman, Arran McBride, Tejaswi Kandula, Holly A Dubbs, Rebecca Macintosh, Michael Cardamone, Ying Zhu, Kevin Ying, Kerith-Rae Dias, Megan T Cho, Lindsay B Henderson, Berivan Baskin, Paula Morris, Jiang Tao, Mark J Cowley, Marcel E Dinger, Tony Roscioli, Oana Caluseriu, Oksana Suchowersky, Rani K Sachdev, Olivier Lichtarge, Jianrong Tang, Kym M Boycott, J Lloyd Holder, Huda Y Zoghbi
Certain mutations can cause proteins to accumulate in neurons, leading to neurodegeneration. We recently showed, however, that upregulation of a wild-type protein, Ataxin1, caused by haploinsufficiency of its repressor, the RNA-binding protein Pumilio1 (PUM1), also causes neurodegeneration in mice. We therefore searched for human patients with PUM1 mutations. We identified eleven individuals with either PUM1 deletions or de novo missense variants who suffer a developmental syndrome (Pumilio1-associated developmental disability, ataxia, and seizure; PADDAS)...
February 22, 2018: Cell
https://www.readbyqxmd.com/read/29474868/active-site-c-p-loop-dynamics-modulate-substrate-binding-catalysis-oligomerization-stability-over-oxidation-and-recycling-of-2-cys-peroxiredoxins
#9
Neelagandan Kamariah, Birgit Eisenhaber, Frank Eisenhaber, Gerhard Grüber
Peroxiredoxins (Prxs) catalyse the rapid reduction of hydrogen peroxide, organic hydroperoxide and peroxynitrite, using a fully conserved peroxidatic cysteine (CP ) located in a conserved sequence Pxxx(T/S)xxCP motif known as CP -loop. In addition, Prxs are involved in cellular signaling pathways and regulate several redox-dependent process related disease. The effective catalysis of Prxs is associated with alterations in the CP -loop between reduced, Fully Folded (FF), and oxidized, Locally Unfolded (LU) conformations, which are linked to dramatic changes in the oligomeric structure...
February 20, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29474820/effects-of-two-doses-of-anti-t-lymphocyte-globulin-fresenius-given-after-full-match-sibling-stem-cell-transplantation-in-acute-myeloblastic-leukemia-patients-who-underwent-myeloablative-fludarabine-busulfan-conditioning
#10
Can Boga, Mahmut Yeral, Ciğdem Gereklioglu, Suheyl Asma, Erkan Maytalman, Pelin Aytan, Ilknur Kozanoglu, Cagla Sariturk, Hakan Ozdogu
OBJECTIVE/BACKGROUND: Anti-T lymphocyte globulin Fresenius (rATG-F; ATG-Fresenius) and antithymocyte globulin (thymoglobulin), which are included in transplant protocols, are used to reduce the risk of chronic graft-versus-host disease (cGVHD) or suppress allograft rejection. Available clinical studies have been conducted in heterogenous patient populations and with different administration protocols including stem cell sources. Additionally, the pharmacokinetics of ATG is variable, and the clinically effective dose of rATG-F, in particular, is not exactly known...
February 20, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29474800/validity-of-the-4-compartment-model-using-dual-energy-x-ray-absorptiometry-derived-body-volume-in-overweight-individuals
#11
Malia N M Blue, Katie R Hirsch, Eric T Trexler, Abbie E Smith-Ryan
The purpose of the present study was to assess the validity of dual-energy X-ray absorptiometry (DXA) to estimate body volume (BV) for use in a four-compartment (4C) body composition model in an overweight/obese population. Body composition of 61 overweight/obese adults (Age: 37.3 ± 10.0 yrs; Height: 170.2 ± 9.5 cm; Body mass: 97.1 ± 17.4 kg) was measured by two methods: a criterion 4C model and a DXA-derived BV 4C model. For both models, bioelectrical impedance spectroscopy was used to estimate total body water; total body bone mineral content was measured by a full body DXA scan...
February 23, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29474563/effects-of-heat-stress-during-porcine-reproductive-and-respiratory-syndrome-virus-infection-on-metabolic-responses-in-growing-pigs
#12
K M Seelenbinder, L D Zhao, M D Hanigan, M W Hulver, R P McMillan, L H Baumgard, J T Selsby, J W Ross, N K Gabler, R P Rhoads
Heat stress and immune challenges negatively impact nutrient allocation and metabolism in swine, especially due to elevated heat load. In order to assess the effects of heat stress during porcine reproductive and respiratory syndrome virus (PRRSV) infection on metabolism, 9-week old crossbred barrows were individually housed, fed ad libitum, divided into four treatments: thermo-neutral (TN), thermo-neutral PRRSV infected (TP), heat stress (HS), and heat stress PRRSV infected (HP), and subjected to two experimental phases...
February 21, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29474542/lack-of-correlation-of-desiccation-and-radiation-tolerance-in-microorganisms-from-diverse-extreme-environments-tested-under-anoxic-conditions
#13
Kristina Beblo-Vranesevic, Maria Bohmeier, Alexandra K Perras, Petra Schwendner, Elke Rabbow, Christine Moissl-Eichinger, Charles S Cockell, Pauline Vannier, Viggo T Marteinsson, Euan P Monaghan, Pascale Ehrenfreund, Laura Garcia-Descalzo, Felipe Gómez, Moustafa Malki, Ricardo Amils, Frédéric Gaboyer, Frances Westall, Patricia Cabezas, Nicolas Walter, Petra Rettberg
Four facultative anaerobic and two obligate anaerobic bacteria were isolated from extreme environments (deep subsurface halite mine, sulfidic anoxic spring, mineral-rich river) in the frame MASE (Mars Analogues for Space Exploration) project. The isolates were investigated under anoxic conditions for their survivability after desiccation up to six months and their tolerance to ionizing radiation up to 3000 Gy. The results indicated that tolerances to both stresses are strain-specific features. Yersinia intermedia MASE-LG-1 showed a high desiccation tolerance but its radiation tolerance was very low...
February 21, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29474490/reproducibility-of-estimated-optimal-peak-output-using-a-force-velocity-test-on-a-cycle-ergometer
#14
Manuel J Coelho-E-Silva, Ricardo Rebelo-Gonçalves, Diogo Martinho, Alexis Ahmed, Leonardo G O Luz, João P Duarte, Vítor Severino, Rafael C Baptista, João Valente-Dos-Santos, Vasco Vaz, Rui S Gonçalves, Antonio Tessitore, António J Figueiredo
The current study aimed to examine the reproducibility of estimated peak power and estimated pedal velocity in a multi-trial 10-s all-out cycling test among adult athletes (n = 22; aged 23.50±4.73 years). Stature, sitting height and body mass were measured. Leg length was estimated as stature minus sitting height. Body volume was obtained from air displacement plethysmography and was subsequently used to calculate body density. Fat mass and fat-free mass were derived. The short-term power outputs were assessed from the force-velocity test (FVT), using a friction-braked ergometer on two separated occasions...
2018: PloS One
https://www.readbyqxmd.com/read/29474450/treatment-with-native-heterodimeric-il-15-increases-cytotoxic-lymphocytes-and-reduces-shiv-rna-in-lymph-nodes
#15
Dionysios C Watson, Eirini Moysi, Antonio Valentin, Cristina Bergamaschi, Santhi Devasundaram, Sotirios P Fortis, Jenifer Bear, Elena Chertova, Julian Bess, Ray Sowder, David J Venzon, Claire Deleage, Jacob D Estes, Jeffrey D Lifson, Constantinos Petrovas, Barbara K Felber, George N Pavlakis
B cell follicles in secondary lymphoid tissues represent an immune privileged sanctuary for AIDS viruses, in part because cytotoxic CD8+ T cells are mostly excluded from entering the follicles that harbor infected T follicular helper (TFH) cells. We studied the effects of native heterodimeric IL-15 (hetIL-15) treatment on uninfected rhesus macaques and on macaques that had spontaneously controlled SHIV infection to low levels of chronic viremia. hetIL-15 increased effector CD8+ T lymphocytes with high granzyme B content in blood, mucosal sites and lymph nodes, including virus-specific MHC-peptide tetramer+ CD8+ cells in LN...
February 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29474442/dysregulation-of-the-ifn-%C3%AE-stat1-signaling-pathway-in-a-cell-line-model-of-large-granular-lymphocyte-leukemia
#16
Paige M Kulling, Kristine C Olson, Cait E Hamele, Mariella F Toro, Su-Fern Tan, David J Feith, Thomas P Loughran
T cell large granular lymphocyte leukemia (T-LGLL) is a rare incurable disease that is characterized by defective apoptosis of cytotoxic CD8+ T cells. Chronic activation of the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway is a hallmark of T-LGLL. One manifestation is the constitutive phosphorylation of tyrosine 701 of STAT1 (p-STAT1). T-LGLL patients also exhibit elevated serum levels of the STAT1 activator, interferon-γ (IFN-γ), thus contributing to an inflammatory environment...
2018: PloS One
https://www.readbyqxmd.com/read/29474429/early-eocene-deep-sea-benthic-foraminiferal-faunas-recovery-from-the-paleocene-eocene-thermal-maximum-extinction-in-a-greenhouse-world
#17
Gabriela J Arreguín-Rodríguez, Ellen Thomas, Simon D'haenens, Robert P Speijer, Laia Alegret
The early Eocene greenhouse world was marked by multiple transient hyperthermal events. The most extreme was the Paleocene-Eocene Thermal Maximum (PETM, ~56 Ma), linked to the extinction of the globally recognised deep-sea benthic foraminiferal Velasco fauna, which led to the development of early Eocene assemblages. This turnover has been studied at high resolution, but faunal development into the later early Eocene is poorly documented. There is no widely accepted early Eocene equivalent of the Late Cretaceous-Paleocene Velasco fauna, mainly due to the use of different taxonomic concepts...
2018: PloS One
https://www.readbyqxmd.com/read/29474427/cerebrospinal-fluid-scd27-levels-indicate-active-t-cell-mediated-inflammation-in-premanifest-huntington-s-disease
#18
Valter Niemelä, Joachim Burman, Kaj Blennow, Henrik Zetterberg, Anders Larsson, Jimmy Sundblom
INTRODUCTION: Huntington's disease (HD) is a neurodegenerative disorder, but evidence also suggests neuroinflammation in the pathogenesis. The immune mechanisms involved and the timing of their activation need further clarification. METHODS: A clinically well-characterized HD cohort and gene negative controls were enrolled. YKL-40 reflecting innate immunity and sCD27, a marker of adaptive immunity, were measured across disease stages. Comparisons were made with markers of neurodegeneration: neurofilament light (NFL), total-tau (T-tau), and phospho-tau (P-tau)...
2018: PloS One
https://www.readbyqxmd.com/read/29474313/perception-of-patient-safety-culture-in-pediatric-long-term-care-settings
#19
Amanda J Hessels, Meghan T Murray, Bevin Cohen, Elaine L Larson
INTRODUCTION: Patient safety culture (PSC) is an emerging construct in adult long-term care settings. No measures are validated to quantify PSC in pediatric long-term care (pLTC) settings despite the importance of safety for this vulnerable population. The study purposes are to (1) describe PSC in pLTC, (2) assess the relationship of PSC to facility recommendation and overall safety rating, and (3) test the stability and reliability of the PSC survey over time. METHODS: A modified Nursing Home PSC (NHSPSC) survey was administered to employees at three pLTC facilities over 3 years; data were summarized and compared over time...
February 16, 2018: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/29474292/changes-in-the-vaginal-microenvironment-as-related-to-frequency-of-pessary-removal
#20
Nicole J Fregosi, Deslyn T G Hobson, Casey L Kinman, Jeremy T Gaskins, J Ryan Stewart, Kate V Meriwether
OBJECTIVE: The aim of the study was to describe the effect of frequency of pessary removal on the vaginal microenvironment. METHODS: We performed a secondary analysis of a multicenter randomized trial of hydroxyquinoline gel in women presenting for pessary fitting. Patients had vaginal secretions analyzed at baseline, 2 weeks, and 3 months. Patients were stratified by frequency of pessary removal at least once daily, at least once weekly, and less often than once weekly...
March 2018: Female Pelvic Medicine & Reconstructive Surgery
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