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JOURNAL ARTICLE
Enrique Soto-Perez-de-Celis, William Dale, Vani Katheria, Heeyoung Kim, Marwan Fakih, Vincent M Chung, Dean Lim, Joanne Mortimer, Leana Cabrera Chien, Kemeberly Charles, Elsa Roberts, Jessica Vazquez, Jeanine Moreno, Ty Lee, Simone Fernandes Dos Santos Hughes, Mina S Sedrak, Can-Lan Sun, Daneng Li
INTRODUCTION: Older adults with cancer facing competing treatments must prioritize between various outcomes. This study assessed health outcome prioritization among older adults with cancer starting chemotherapy. METHODS: Secondary analysis of a randomized trial addressing vulnerabilities in older adults with cancer. Patients completed three validated outcome prioritization tools: 1) Health Outcomes Tool: prioritizes outcomes (survival, independence, symptoms) using a visual analog scale; 2) Now vs...
April 17, 2024: Cancer
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JOURNAL ARTICLE
Salvatore Minisola, Cristiana Cipriani, Luciano Colangelo, Jessica Pepe
A 47-year-old postmenopausal woman with osteoporosis was treated with denosumab, which was discontinued due to side effects. She was therefore transitioned to a yearly intravenous infusion of zoledronic acid. An increase in bone turnover markers together with bone loss at the lumbar spine was observed before the second infusion, suggesting an overshooting of bone resorption due to denosumab discontinuation. On physical examination, the patient was restless and reported having lost about 10 kg since the last visit...
March 4, 2024: Journal of Bone and Mineral Research
#3
JOURNAL ARTICLE
Vincent T Cooper, Kyle C Armour, Gregory J Hakim, Jessica E Tierney, Matthew B Osman, Cristian Proistosescu, Yue Dong, Natalie J Burls, Timothy Andrews, Daniel E Amrhein, Jiang Zhu, Wenhao Dong, Yi Ming, Philip Chmielowiec
Here, we show that the Last Glacial Maximum (LGM) provides a stronger constraint on equilibrium climate sensitivity (ECS), the global warming from increasing greenhouse gases, after accounting for temperature patterns. Feedbacks governing ECS depend on spatial patterns of surface temperature ("pattern effects"); hence, using the LGM to constrain future warming requires quantifying how temperature patterns produce different feedbacks during LGM cooling versus modern-day warming. Combining data assimilation reconstructions with atmospheric models, we show that the climate is more sensitive to LGM forcing because ice sheets amplify extratropical cooling where feedbacks are destabilizing...
April 19, 2024: Science Advances
#4
JOURNAL ARTICLE
Sung-Mok Jung, Sara L Loo, Emily Howerton, Lucie Contamin, Claire P Smith, Erica C Carcelén, Katie Yan, Samantha J Bents, John Levander, Jessi Espino, Joseph C Lemaitre, Koji Sato, Clifton D McKee, Alison L Hill, Matteo Chinazzi, Jessica T Davis, Kunpeng Mu, Alessandro Vespignani, Erik T Rosenstrom, Sebastian A Rodriguez-Cartes, Julie S Ivy, Maria E Mayorga, Julie L Swann, Guido España, Sean Cavany, Sean M Moore, T Alex Perkins, Shi Chen, Rajib Paul, Daniel Janies, Jean-Claude Thill, Ajitesh Srivastava, Majd Al Aawar, Kaiming Bi, Shraddha Ramdas Bandekar, Anass Bouchnita, Spencer J Fox, Lauren Ancel Meyers, Przemyslaw Porebski, Srini Venkatramanan, Aniruddha Adiga, Benjamin Hurt, Brian Klahn, Joseph Outten, Jiangzhuo Chen, Henning Mortveit, Amanda Wilson, Stefan Hoops, Parantapa Bhattacharya, Dustin Machi, Anil Vullikanti, Bryan Lewis, Madhav Marathe, Harry Hochheiser, Michael C Runge, Katriona Shea, Shaun Truelove, Cécile Viboud, Justin Lessler
BACKGROUND: Coronavirus Disease 2019 (COVID-19) continues to cause significant hospitalizations and deaths in the United States. Its continued burden and the impact of annually reformulated vaccines remain unclear. Here, we present projections of COVID-19 hospitalizations and deaths in the United States for the next 2 years under 2 plausible assumptions about immune escape (20% per year and 50% per year) and 3 possible CDC recommendations for the use of annually reformulated vaccines (no recommendation, vaccination for those aged 65 years and over, vaccination for all eligible age groups based on FDA approval)...
April 17, 2024: PLoS Medicine
#5
JOURNAL ARTICLE
Ari S Freedman, Justin K Sheen, Stella Tsai, Jihong Yao, Edward Lifshitz, David Adinaro, Simon A Levin, Bryan T Grenfell, C Jessica E Metcalf
Characterizing the relationship between disease testing behaviors and infectious disease dynamics is of great importance for public health. Tests for both current and past infection can influence disease-related behaviors at the individual level, while population-level knowledge of an epidemic's course may feed back to affect one's likelihood of taking a test. The COVID-19 pandemic has generated testing data on an unprecedented scale for tests detecting both current infection (PCR, antigen) and past infection (serology); this opens the way to characterizing the complex relationship between testing behavior and infection dynamics...
April 23, 2024: Proceedings of the National Academy of Sciences of the United States of America
#6
JOURNAL ARTICLE
Jessica L Couture, Darcy Bradley, Benjamin S Halpern, Steven D Gaines
The global population consumes more seafood from aquaculture today than from capture fisheries and although the aquaculture industry continues to grow, both seafood sectors will continue to be important to the global food supply into the future. As farming continues to expand into ocean systems, understanding how wild populations and fisheries will interact with farms will be increasingly important to informing sustainable ocean planning and management. Using a spatially explicit population and fishing model we simulate several impacts from ocean aquaculture (i...
2024: PloS One
#7
JOURNAL ARTICLE
Jessica G Young
No abstract text is available yet for this article.
May 1, 2024: Epidemiology
#8
JOURNAL ARTICLE
Yu Jun Wong, Vincent L Chen, Asim Abdulhamid, Giulia Tosetti, Huttakan Navadurong, Apichat Kaewdech, Jessica Cristiu, Michael Song, Pooja Devan, Kai Le Ashley Tiong, Jean Ee Neo, Thaninee Prasoppokakorn, Pimsiri Sripongpun, Catherine Ann Malcolm Stedman, Sombat Treeprasertsuk, Massimo Primignani, Jing Hieng Ngu, Juan G Abraldes
INTRODUCTION: The utility of serial liver stiffness measurements (LSM) to predict decompensation in compensated advanced chronic liver disease (cACLD) patients remains unclear. We aimed to validate whether comparing serial LSM is superior to using the current LSM to predict liver-related events (LRE) in cACLD patients. METHODS: In this retrospective analysis of an international registry, cACLD patients with serial LSM were followed up until index LRE. We compared the performance of both the dynamic LSM changes and the current LSM (LSMc ) in predicting LRE using Cox-regression analysis, considering time zero of follow-up as the date of LSMc...
April 17, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#9
JOURNAL ARTICLE
Jessica A Kern, Brian R Hinds, Veronica Shi
No abstract text is available yet for this article.
April 17, 2024: JAMA Dermatology
#10
REVIEW
Jothika V Challapalli, Jessica H Yoon, Robert C Ward
Breast cryoablation is a minimally invasive image-guided percutaneous procedure to treat fibroadenomas and early-stage breast cancer utilizing liquid nitrogen or argon gas to create extremely cold temperatures that devitalize targeted tissue. Although more long term data are needed, this outpatient procedure is well tolerated and carries minimal risks, including non-target thermal injury that can be mitigated by careful planning and proper technique. Building a sustainable breast cryoablation service in a radiology practice poses several practical considerations, such as training proceduralists, purchasing equipment, recruiting patients, and understanding the revenue cycle...
April 17, 2024: AJR. American Journal of Roentgenology
#11
JOURNAL ARTICLE
Lisa M Pick, Viviane Oehme, Julia Hartmann, Jessica Wenzlaff, Qingyun Tang, Gideon Grogan, Marion B Ansorge-Schumacher
Silyl ethers fulfil a fundamental role in synthetic organic chemistry as protecting groups and their selective cleavage is an important factor in their application. We present here for the first time two enzymes, SilE-R and SilE-S, which are able to hydrolyze silyl ethers. They belong to the stress-response A/B barrel domain (DABB) family and are able to cleave the Si-O bond with opposite enantiopreference. Silyl ethers containing aromatic, cyclic or aliphatic alcohols and, depending on the alcohol moiety, silyl functions as large as TBDMS are accepted...
April 17, 2024: Angewandte Chemie
#12
Jessica Colombé
No abstract text is available yet for this article.
April 17, 2024: Revue Médicale Suisse
#13
JOURNAL ARTICLE
Emanuele Tanzi, Simona Maria Di Modica, Jessica Bordini, Violante Olivari, Alessia Pagani, Valeria Furiosi, Laura Silvestri, Alessandro Campanella, Antonella Nai
β-thalassemia is a disorder characterized by anemia, ineffective erythropoiesis (IE), and iron overload, whose treatment still requires improvement. The activin receptor-ligand trap Luspatercept, a novel therapeutic option for β-thalassemia, stimulates erythroid differentiation inhibiting the transforming growth factor β pathway. However, its exact mechanism of action and the possible connection with erythropoietin (Epo), the erythropoiesis governing cytokine, remain to be clarified. Moreover, Luspatercept does not correct all the features of the disease, calling for the identification of strategies that enhance its efficacy...
April 17, 2024: American Journal of Hematology
#14
JOURNAL ARTICLE
Debora Paulino da Silva Almeida, Paulo Leandro de Oliveira Junior, Glauber Alves Dos Prazeres, Lorrayne Belotti, Jessica Domingues, Natalia Martins Bonassi, Ilana Eshriqui, Renata Soares Martins, Leticia Yamawaka de Almeida, Daiana Bonfim
OBJECTIVE: Describe the implementation of a digital diagnostic and territorial monitoring tool in primary healthcare. METHODS: Quantitative and qualitative study, developed in 14 basic healthcare units in São Paulo, with community health workers, coordinators, nurses, and physicians. Data collection occurred in four phases: analysis of the instruments used by the team for territory management; development of the digital tool; training and implementation; and evaluation after 90 days using focus groups...
2024: Revista de Saúde Pública
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JOURNAL ARTICLE
Davia A Schioppo, Jessica P H Greenwood, Kristen A Miller, Hetal S Vig
Purpose: Oncology clinicians are appropriately positioned to facilitate discussions of assisted reproductive technologies including preimplantation genetic testing for monogenic disease (PGT-M), in the context of cancer treatment or surveillance. Yet, reproductive services, including PGT-M, remain one of the least implemented services in oncology. No studies to date have explored which practice resources the clinicians need to increase knowledge of PGT-M. The objective of this study was to explore the specific needs of oncology clinicians to help maximize the reproductive potential of young adult patients with hereditary cancers...
April 17, 2024: Journal of Adolescent and Young Adult Oncology
#16
JOURNAL ARTICLE
Jihyun Song, Lucie Lanikova, Soo Jin Kim, Nicolas Papadopoulos, Jessica Meznarich, Stefan N Constantinescu, Brynn Parsegov, Jaroslav F Prchal, Josef T Prchal
Polycythemia vera (PV) is a clonal disorder arising from the acquired somatic mutations of the JAK2 gene, including JAK2V617F or several others in exon 12. A 38-year-old female had a stroke at age 32 and found to have elevated hemoglobin, normal leukocytes, normal platelets, and tested negative for JAK2V617F and exon 12 mutations. Next generation sequencing revealed a novel mutation: JAK2R715T in the pseudokinase domain (JH2) at 47.5%. Its presence in her nail DNA confirmed a germline origin. Her mother and her son similarly had erythrocytosis and a JAK2R715T mutation...
April 17, 2024: American Journal of Hematology
#17
JOURNAL ARTICLE
Thera Koetsier, Jessica Apeldoorn, Annet Nugter
Background: Imagery rescripting (ImRs) has shown to be an effective treatment for posttraumatic stress disorders (PTSD) resulting from childhood-related trauma. The current theory is that the change of meaning of the trauma memory is central to the treatment. Several authors have suggested that the expression of needs, feelings and actions may act as potential healing factors, but little specific research aimed at (in)validating this hypothesis has been done so far. Objective: In this study we investigated to what extent the expression of inhibited action tendencies and the fulfilling of needs lead to the reduction of PTSD symptoms in clients with early childhood trauma...
2024: European Journal of Psychotraumatology
#18
JOURNAL ARTICLE
Deepak Bansal, Hadi Ghahramanzadehasl, Drialys Cardenas-Morcoso, Jessica Desport, Gilles Frache, Giuseppe Bengasi, Nicolas D Boscher
The oxidative coupling reaction of two Ni(II) porphyrins meso-substituted with three and four phenyl groups, Ni(II) 5,10,15-(triphenyl)porphyrin (NiPh3P) and Ni(II) 5,10,15,20-(tetraphenyl)porphyrin (NiPh4P) respectively, was investigated in a oxidative chemical vapor deposition (oCVD) process. Irrespective of the number of meso-substituents, high-resolution mass spectrometry evidences the formation of oligomeric species containing up to five porphyrin units. UV-Vis-NIR and XPS analyses of the oCVD films highlighted a strong dependence of the intermolecular coupling reaction with the substrate temperature...
April 17, 2024: Chemistry: a European Journal
#19
JOURNAL ARTICLE
Jolanda Malamud, Gemma Lewis, Michael Moutoussis, Larisa Duffy, Jessica Bone, Ramya Srinivasan, Glyn Lewis, Quentin J M Huys
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are first-line pharmacological treatments for depression and anxiety. However, little is known about how pharmacological action is related to cognitive and affective processes. Here, we examine whether specific reinforcement learning processes mediate the treatment effects of SSRIs. METHODS: The PANDA trial was a multicentre, double-blind, randomized clinical trial in UK primary care comparing the SSRI sertraline with placebo for depression and anxiety...
April 17, 2024: Psychological Medicine
#20
REVIEW
Lauren Dietz, Jessica Marini, Hamza Hashmi, Mary McGann
High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation is the standard of care for eligible patients with newly diagnosed multiple myeloma leading to prolonged progression free and overall survival. Successful engraftment following hematopoietic stem cell infusion requires adequate stem cell doses. Current mobilization regimens include granulocyte colony-stimulating factor (G-CSF) with or without plerixafor. Motixafortide is a recently approved agent that can be used in combination with G-CSF for mobilization...
April 17, 2024: Journal of Oncology Pharmacy Practice
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