keyword
https://read.qxmd.com/read/37632085/the-burden-of-epstein-barr-virus-ebv-and-its-determinants-among-adult-hiv-positive-individuals-in-ethiopia
#21
JOURNAL ARTICLE
Kidist Zealiyas, Seifegebriel Teshome, Nega Berhe, Wondwossen Amogne, Aklilu Feleke Haile, Ebba Abate, Getnet Yimer, Christoph Weigel, Elshafa Hassan Ahmed, Tamrat Abebe, Robert Baiocchi
Epstein-Barr virus (EBV) is a well-known risk factor for the development of nasopharyngeal carcinoma, Hodgkin's lymphoma (HL), and Non-Hodgkin's lymphoma (NHL). People with HIV infection (PWH) are at increased risk for EBV-associated malignancies such as HL and NHL. Nevertheless, there are limited data on the burden of EBV among this population group in Ethiopia. Hence, this study aimed to determine the burden of EBV infection among adult HIV-positive individuals in Ethiopia and assess the determinants of EBV DNA positivity...
August 15, 2023: Viruses
https://read.qxmd.com/read/37583699/tissue-factor-as-a-potential-coagulative-vascular-marker-in-relapsing-remitting-multiple-sclerosis
#22
JOURNAL ARTICLE
Tatiana Koudriavtseva, Svetlana Lorenzano, Maria Cellerino, Mauro Truglio, Marco Fiorelli, Caterina Lapucci, Giovanna D'Agosto, Laura Conti, Annunziata Stefanile, Silvana Zannino, Maria Maddalena Filippi, Antonio Cortese, Carlo Piantadosi, Marta Maschio, Andrea Maialetti, Edvina Galiè, Marco Salvetti, Matilde Inglese
OBJECTIVES: Recent studies supported coagulation involvement in multiple sclerosis, an inflammatory-demyelinating and degenerative disease of the central nervous system. The main objectives of this observational study were to identify the most specific pro-coagulative/vascular factors for multiple sclerosis pathogenesis and to correlate them with brain hemodynamic abnormalities. METHODS: We compared i) serum/plasma levels of complement(C)/coagulation/vascular factors, viral/microbiological assays, fat-soluble vitamins and lymphocyte count among people with multiple sclerosis sampled in a clinical remission ( n =30; 23F/7M, 40 ± 8...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37569339/serum-and-saliva-level-of-mir-31-5p-and-mir-let-7a-in-ebv-associated-oropharyngeal-cancer
#23
JOURNAL ARTICLE
Anna Polz, Kamal Morshed, Robert Bibik, Bartłomiej Drop, Andrzej Drop, Małgorzata Polz-Dacewicz
Epstein-Barr virus (EBV) has a well-documented association with head and neck neoplasms, including nasopharyngeal carcinoma (NPC). In the last few years, research aimed at elucidating the role of the miRs in the pathogenesis of head and neck cancer (HNC) has gained importance. The study of miRs expression has set new directions in the search for biomarkers with diagnostic and prognostic value, and even in the search for new therapeutic targets for various tumors, including HNC. The aim of current study was to approximate the importance of miR-31-5p and miR-let 7a in the pathogenesis of EBV associated oropharyngeal cancer...
July 26, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37561629/epstein-barr-virus-evades-restrictive-host-chromatin-closure-by-subverting-b-cell-activation-and-germinal-center-regulatory-loci
#24
JOURNAL ARTICLE
Elliott D SoRelle, Nicolás M Reinoso-Vizcaino, Joanne Dai, Ashley P Barry, Cliburn Chan, Micah A Luftig
Chromatin accessibility fundamentally governs gene expression and biological response programs that can be manipulated by pathogens. Here we capture dynamic chromatin landscapes of individual B cells during Epstein-Barr virus (EBV) infection. EBV+ cells that exhibit arrest via antiviral sensing and proliferation-linked DNA damage experience global accessibility reduction. Proliferative EBV+ cells develop expression-linked architectures and motif accessibility profiles resembling in vivo germinal center (GC) phenotypes...
August 9, 2023: Cell Reports
https://read.qxmd.com/read/37513762/distribution-of-epstein-barr-virus-lmp1-variants-in-patients-with-infectious-mononucleosis-and-association-with-selected-biochemical-and-hematological-parameters
#25
JOURNAL ARTICLE
Snjezana Zidovec-Lepej, Margarita Batovic, Marija Rozman, Kristian Bodulić, Laura Prtorić, Ante Šokota, Andrea Nikcevic, Petra Simicic, Goran Tešović
The molecular diversity of Epstein-Barr virus (EBV) is exceptionally complex and based on the characterization of sequences coding for several viral genes. The aim of this study was to analyze the distribution of EBV types 1 and 2 and to characterize LMP1 variants in a cohort of 73 patients with infectious mononucleosis (IM), as well as to investigate a possible association between viral diversity and relevant clinical parameters. Population-based sequencing of EBNA-2 gene showed the presence of EBV type 1 in all IM patients...
July 6, 2023: Pathogens
https://read.qxmd.com/read/37306550/risk-of-a-first-clinical-diagnosis-of-cns-demyelination-in-relation-to-human-herpesviruses-in-the-context-of-epstein-barr-virus
#26
JOURNAL ARTICLE
Robyn M Lucas, M-L J Lay, James Grant, Nicolas Cherbuin, Cheryl S Toi, Keith Dear, Bruce V Taylor, Dominic E Dwyer, Anne-Louise Ponsonby
BACKGROUND: Epstein-Barr virus (EBV) is implicated in MS risk; evidence for other herpesviruses is inconsistent. Here we test blood markers of infection with Human herpesvirus 6 (HHV-6), varicella-zoster virus (VZV) and cytomegalovirus (CMV), as risk factors for a first clinical diagnosis of CNS demyelination (FCD) in the context of markers of EBV infection. METHODS: In the Ausimmune case-control study, cases had a FCD and population controls were matched on age, sex and study region...
June 12, 2023: European Journal of Neurology
https://read.qxmd.com/read/37159273/patient-tailored-adoptive-immunotherapy-with-ebv-specific-t-cells-from-related-and-unrelated-donors
#27
JOURNAL ARTICLE
Agnes Bonifacius, Britta Lamottke, Sabine Tischer-Zimmermann, Rebecca Schultze-Florey, Lilia Goudeva, Hans-Gert Heuft, Lubomir Arseniev, Rita Beier, Gernot Beutel, Gunnar Cario, Birgit Fröhlich, Johann Greil, Leo Hansmann, Justin Hasenkamp, Michaela Höfs, Patrick Hundsdoerfer, Edgar Jost, Kinan Kafa, Oliver Kriege, Nicolaus Kröger, Stephan Mathas, Roland Meisel, Michaela Nathrath, Mervi Putkonen, Sarina Ravens, Hans Christian Reinhardt, Elisa Sala, Martin G Sauer, Clemens Schmitt, Roland Schroers, Nina Kristin Steckel, Ralf Ulrich Trappe, Mareike Verbeek, Daniel Wolff, Rainer Blasczyk, Britta Eiz-Vesper, Britta Maecker-Kolhoff
BACKGROUNDAdoptive transfer of EBV-specific T cells can restore specific immunity in immunocompromised patients with EBV-associated complications.METHODSWe provide results of a personalized T cell manufacturing program evaluating donor, patient, T cell product, and outcome data. Patient-tailored clinical-grade EBV-specific cytotoxic T lymphocyte (EBV-CTL) products from stem cell donors (SCDs), related third-party donors (TPDs), or unrelated TPDs from the allogeneic T cell donor registry (alloCELL) at Hannover Medical School were manufactured by immunomagnetic selection using a CliniMACS Plus or Prodigy device and the EBV PepTivators EBNA-1 and Select...
June 15, 2023: Journal of Clinical Investigation
https://read.qxmd.com/read/37112815/epstein-barr-virus-b-cell-growth-transformation-the-nuclear-events
#28
REVIEW
Bo Zhao
Epstein-Barr virus (EBV) is the first human DNA tumor virus identified from African Burkitt's lymphoma cells. EBV causes ~200,000 various cancers world-wide each year. EBV-associated cancers express latent EBV proteins, EBV nuclear antigens (EBNAs), and latent membrane proteins (LMPs). EBNA1 tethers EBV episomes to the chromosome during mitosis to ensure episomes are divided evenly between daughter cells. EBNA2 is the major EBV latency transcription activator. It activates the expression of other EBNAs and LMPs...
March 24, 2023: Viruses
https://read.qxmd.com/read/37068736/comparison-of-real-time-pcr-and-digital-pcr-for-detection-of-plasma-epstein-barr-virus-dna-in-nasopharyngeal-carcinoma
#29
JOURNAL ARTICLE
Jacob A Miller, ChunHong Huang, Fumiko Yamamoto, Malaya K Sahoo, Quynh-Thu Le, Benjamin A Pinsky
Plasma Epstein-Barr Virus (EBV) DNA is an established biomarker for endemic nasopharyngeal carcinoma (NPC). However, existing real-time PCR (qPCR) assays are limited by poor inter-laboratory reproducibility. This is a barrier to biomarker integration into staging systems and management. It was hypothesized that EBV digital PCR (dPCR) would have similar sensitivity but improved precision relative to qPCR. Using the WHO EBV standard and patient specimens, the NRG BamHI-W qPCR, two commercial EBNA-1 qPCR assays, and two laboratory-developed dPCR assays amplifying the BamHI-W, EBNA-1, and EBER targets were compared...
April 15, 2023: Journal of Molecular Diagnostics: JMD
https://read.qxmd.com/read/36999015/design-of-a-multi-epitopic-vaccine-against-epstein-barr-virus-via-computer-based-methods
#30
JOURNAL ARTICLE
Amirhossein Larijani, Ali Kia-Karimi, Davoud Roostaei
BACKGROUND: Scientific findings have shown that Epstein-Barr virus (EBV) plays a key role in the development of some tumor diseases. Therefore, this study intends to take a practical step in controlling the pathogenicity of this virus by designing an effective vaccine based on the virus Capsid Envelope and Epstein-Barr nuclear immunogen (EBNA) Proteins Epitopes. Currently, there are no effective drugs or vaccines to treat or prevent EBV infection. So, we applied a computer-based strategy to design an epitope vaccine...
2023: Frontiers in Immunology
https://read.qxmd.com/read/36992464/co-detection-of-ebv-and-human-polyomavirus-jcpyv-in-a-case-of-aids-related-multifocal-primary-central-nervous-system-diffuse-large-b-cell-lymphoma
#31
JOURNAL ARTICLE
Mallory T Barbier, Luis Del Valle
The human neurotropic Polyomavirus JCPyV is the widespread opportunistic causative pathogen of the fatal demyelinating disease progressive multifocal leukoencephalopathy; however, it has also been implicated in the oncogenesis of several types of cancers. It causes brain tumors when intracerebrally inoculated into rodents, and genomic sequences of different strains and expression of the viral protein large T-Antigen have been detected in a wide variety of glial brain tumors and CNS lymphomas. Here, we present a case of an AIDS-related multifocal primary CNS lymphoma in which JCPyV genomic sequences of the three regions of JCPyV and expression of T-Antigen were detected by PCR and immunohistochemistry, respectively...
March 15, 2023: Viruses
https://read.qxmd.com/read/36949074/a-dna-tumor-virus-globally-reprograms-host-3d-genome-architecture-to-achieve-immortal-growth
#32
JOURNAL ARTICLE
Chong Wang, Xiang Liu, Jun Liang, Yohei Narita, Weiyue Ding, Difei Li, Luyao Zhang, Hongbo Wang, Merrin Man Long Leong, Isabella Hou, Catherine Gerdt, Chang Jiang, Qian Zhong, Zhonghui Tang, Carmy Forney, Leah Kottyan, Matthew T Weirauch, Benjamin E Gewurz, Mu-Sheng Zeng, Sizun Jiang, Mingxiang Teng, Bo Zhao
Epstein-Barr virus (EBV) immortalization of resting B lymphocytes (RBLs) to lymphoblastoid cell lines (LCLs) models human DNA tumor virus oncogenesis. RBL and LCL chromatin interaction maps are compared to identify the spatial and temporal genome architectural changes during EBV B cell transformation. EBV induces global genome reorganization where contact domains frequently merge or subdivide during transformation. Repressed B compartments in RBLs frequently switch to active A compartments in LCLs. LCLs gain 40% new contact domain boundaries...
March 22, 2023: Nature Communications
https://read.qxmd.com/read/36768715/effect-of-epstein-barr-virus-infection-on-selected-immunological-parameters-in-children-with-type-1-diabetes
#33
JOURNAL ARTICLE
Maria Klatka, Izabela Rysz, Anna Hymos, Agnieszka Polak, Paulina Mertowska, Sebastian Mertowski, Konrad Smolak, Ewelina Grywalska
Diabetes mellitus is a group of metabolic disorders with different etiologies, pathogeneses and clinical pictures, characterized by chronic hyperglycemia due to abnormal insulin secretion or action. Type 1 diabetes mellitus is the most common type of diabetes mellitus in children and adolescents, accounting for about 90% of diabetes in the population under the age of 18. The etiopathogenesis of type 1 diabetes is multifactorial. The disease occurs as a result of the interaction of three factors: genetic predisposition, environmental factors and the immune response...
January 25, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36765601/increased-prevalence-of-ebv-infection-in-nasopharyngeal-carcinoma-patients-a-six-year-cross-sectional-study
#34
JOURNAL ARTICLE
Abdullah E Al-Anazi, Bader S Alanazi, Huda M Alshanbari, Emad Masuadi, Maaweya E Hamed, Iman Dandachi, Abdulrahman Alkathiri, Atif Hanif, Islam Nour, Hanadi Fatani, Hadel Alsaran, Fahad AlKhareeb, Ali Al Zahrani, Abdullah A Alsharm, Saleh Eifan, Bandar Alosaimi
Epstein Barr Virus (EBV) is implicated in the carcinogenesis of nasopharyngeal carcinoma (NPC) and currently associated with at least 1% of global cancers. The differential prognosis analysis of NPC in EBV genotypes remains to be elucidated. Medical, radiological, pathological, and laboratory reports of 146 NPC patients were collected retrospectively over a 6-year period between 2015 and 2020. From the pathology archives, DNA was extracted from tumor blocks and used for EBV nuclear antigen 3C (EBNA-3C) genotyping by nested polymerase chain reaction (PCR)...
January 19, 2023: Cancers
https://read.qxmd.com/read/36723040/diagnosis-of-nasopharyngeal-carcinoma-using-an-ultrasensitive-immunoassay-method-based-on-nanoparticles
#35
JOURNAL ARTICLE
Rui Gong, Chenyang Yang, Ghulam Abbas, Dianbing Wang, Xianen Zhang, Guohui Nie, Hui Ding
The detection of the antibody of Epstein-Barr virus (EBV) is critical for the diagnosis of nasopharyngeal carcinoma (NPC). An accurate and scalable point-of-care detection method would support the screening, diagnosis, and monitoring of NPC patients. In this study, firstly, we made an antibody enrichment element, antigen-MNPs, which can screen out specific antibodies in a complex sample. Secondly, signal-amplifying elements were synthesized by labelling inorganic quantum dots (QDs) and anti-antibodies on the surface of flop-ferritin...
January 27, 2023: Nanoscale
https://read.qxmd.com/read/36675014/dimethyl-fumarate-treatment-reduces-the-amount-but-not-the-avidity-of-the-epstein-barr-virus-capsid-antigen-specific-antibody-response-in-multiple-sclerosis-a-pilot-study
#36
JOURNAL ARTICLE
Massimiliano Castellazzi, Caterina Ferri, Alice Piola, Samantha Permunian, Gaia Buscemi, Michele Laudisi, Eleonora Baldi, Maura Pugliatti
(1) Multiple sclerosis (MS) is a chronic inflammatory disease of autoimmune origin. The Epstein-Barr virus (EBV) is associated with the onset of MS, as almost all patients have high levels of EBV-specific antibodies as a result of a previous infection. We evaluated longitudinally the effects of dimethyl fumarate (DMF), a first-line treatment of MS, on the quantity and quality of EBV-specific IgG in MS patients. (2) Serum samples from 17 MS patients receiving DMF were taken before therapy (T0) and after 1 week (T1) and 1 (T2), 3 (T3) and 6 (T4) months of treatment...
January 12, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36603289/the-concentrations-of-antibodies-to-epstein-barr-virus-decrease-during-ocrelizumab-treatment
#37
JOURNAL ARTICLE
H Phuong T Pham, Sepideh Saroukhani, J William Lindsey
BACKGROUND: Epstein-Barr Virus (EBV) is strongly associated with multiple sclerosis (MS). After initial infection, EBV maintains a life-long latent infection in B lymphocytes. Depletion of B lymphocytes from the blood with the anti-CD20 antibody ocrelizumab (OCR) markedly reduces disease activity in MS. Our objective was to measure the effect of OCR treatment on the antibody response to EBV and human antigens that are cross-reactive with EBV. METHODS: Blood was collected from MS patients before and during OCR treatment...
February 2023: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/36555277/molecular-characterisation-of-epstein-barr-virus-in-classical-hodgkin-lymphoma
#38
JOURNAL ARTICLE
Valerija Begić, Petra Korać, Slavko Gašparov, Marija Rozman, Petra Simicic, Snjezana Zidovec-Lepej
Hodgkin lymphomas (HLs) are a heterogeneous group of lymphoid neoplasia associated with Epstein-Barr virus (EBV) infection. EBV, considered to be an important etiological co-factor in approximately 1% of human malignancies, can be classified into two genotypes based on EBNA-2, EBNA-3A and EBNA-3C sequences, and into genetic variants based on the sequence variation of the gene coding for the LMP1 protein. Here, we present the results on the distribution of EBV genotypes 1 and 2 as well as LMP1 gene variants in 50 patients with EBV-positive classical HL selected from a cohort of 289 histologically verified cases collected over a 9-year period in a tertiary clinical center in the Southeast of Europe...
December 9, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36454631/chronic-viral-coinfections-differentially-affect-the-likelihood-of-developing-long-covid
#39
JOURNAL ARTICLE
Michael J Peluso, Tyler-Marie Deveau, Sadie E Munter, Dylan Ryder, Amanda Buck, Gabriele Beck-Engeser, Fay Chan, Scott Lu, Sarah A Goldberg, Rebecca Hoh, Viva Tai, Leonel Torres, Nikita S Iyer, Monika Deswal, Lynn H Ngo, Melissa Buitrago, Antonio Rodriguez, Jessica Y Chen, Brandon C Yee, Ahmed Chenna, John W Winslow, Christos J Petropoulos, Amelia N Deitchman, Joanna Hellmuth, Matthew A Spinelli, Matthew S Durstenfeld, Priscilla Y Hsue, J Daniel Kelly, Jeffrey N Martin, Steven G Deeks, Peter W Hunt, Timothy J Henrich
BACKGROUNDThe presence and reactivation of chronic viral infections, such as EBV, CMV, and HIV, have been proposed as potential contributors to long COVID (LC), but studies in well-characterized postacute cohorts of individuals with COVID-19 over a longer time course consistent with current case definitions of LC are limited.METHODSIn a cohort of 280 adults with prior SARS-CoV-2 infection, we assessed the presence and types of LC symptoms and prior medical history (including COVID-19 history and HIV status) and performed serological testing for EBV and CMV using a commercial laboratory...
February 1, 2023: Journal of Clinical Investigation
https://read.qxmd.com/read/36444584/detection-of-epstein-barr-nuclear-antigen-1-ebna-1-early-antigen-1f-2r-ea-1f-ea-2r-along-with-epstein-barr-virus-latent-membrane-protein-1-lmp1-in-breast-cancer-of-northern-india-an-interim-analysis
#40
JOURNAL ARTICLE
Vanshika Shahi, Preeti Agarwal, Sumaira Qayoom, Vijay Kumar, Shikha Tewari, Shivanjali Raghuvanshi, Uma Shanker Singh, Madhu Mati Goel
INTRODUCTION: Worldwide, breast cancer (BC)  is a prominent cause of death, with a disproportionately high incidence in developed countries. Epstein-Barr virus (EBV) infection has been reported in up to 90% of the world's population.  Although the exact link of EBV infection and breast carcinoma is not yet determined. The present study was carried out to assess the pathological correlation of EBV infection and BC in women from Northern India. METHODOLOGY: In this prospective observational study, 130 patients with histologically proven breast carcinoma were included...
November 1, 2022: Asian Pacific Journal of Cancer Prevention: APJCP
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