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The Alzheimer's Disease Neuroimaging Initiative, genetic core

Bob Zigon, Huang Li, Xiaohui Yao, Shiaofen Fang, Mohammad Al Hasan, Jingwen Yan, Jason H Moore, Andrew J Saykin, Li Shen
Neuroimaging genomics is an emerging field that provides exciting opportunities to understand the genetic basis of brain structure and function. The unprecedented scale and complexity of the imaging and genomics data, however, have presented critical computational bottlenecks. In this work we present our initial efforts towards building an interactive visual exploratory system for mining big data in neuroimaging genomics. A GPU accelerated browsing tool for neuroimaging genomics is created that implements the ANOVA algorithm for single nucleotide polymorphism (SNP) based analysis and the VEGAS algorithm for gene-based analysis, and executes them at interactive rates...
April 25, 2018: Neuroinformatics
Derek Beaton, Joseph Dunlop, Hervé Abdi
For nearly a century, detecting the genetic contributions to cognitive and behavioral phenomena has been a core interest for psychological research. Recently, this interest has been reinvigorated by the availability of genotyping technologies (e.g., microarrays) that provide new genetic data, such as single nucleotide polymorphisms (SNPs). These SNPs-which represent pairs of nucleotide letters (e.g., AA, AG, or GG) found at specific positions on human chromosomes-are best considered as categorical variables, but this coding scheme can make difficult the multivariate analysis of their relationships with behavioral measurements, because most multivariate techniques developed for the analysis between sets of variables are designed for quantitative variables...
December 2016: Psychological Methods
Erin E Franklin, Richard J Perrin, Benjamin Vincent, Michael Baxter, John C Morris, Nigel J Cairns
INTRODUCTION: The Alzheimer's Disease Neuroimaging Initiative Neuropathology Core (ADNI-NPC) facilitates brain donation, ensures standardized neuropathologic assessments, and maintains a tissue resource for research. METHODS: The ADNI-NPC coordinates with performance sites to promote autopsy consent, facilitate tissue collection and autopsy administration, and arrange sample delivery to the NPC, for assessment using National Institute on Aging-Alzheimer's Association neuropathologic diagnostic criteria...
July 2015: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Ju-Hee Kang, Magdalena Korecka, Michal J Figurski, Jon B Toledo, Kaj Blennow, Henrik Zetterberg, Teresa Waligorska, Magdalena Brylska, Leona Fields, Nirali Shah, Holly Soares, Robert A Dean, Hugo Vanderstichele, Ronald C Petersen, Paul S Aisen, Andrew J Saykin, Michael W Weiner, John Q Trojanowski, Leslie M Shaw
INTRODUCTION: We describe Alzheimer's Disease Neuroimaging Initiative (ADNI) Biomarker Core progress including: the Biobank; cerebrospinal fluid (CSF) amyloid beta (Aβ1-42), t-tau, and p-tau181 analytical performance, definition of Alzheimer's disease (AD) profile for plaque, and tangle burden detection and increased risk for progression to AD; AD disease heterogeneity; progress in standardization; and new studies using ADNI biofluids. METHODS: Review publications authored or coauthored by ADNI Biomarker core faculty and selected non-ADNI studies to deepen the understanding and interpretation of CSF Aβ1-42, t-tau, and p-tau181 data...
July 2015: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Li Shen, Paul M Thompson, Steven G Potkin, Lars Bertram, Lindsay A Farrer, Tatiana M Foroud, Robert C Green, Xiaolan Hu, Matthew J Huentelman, Sungeun Kim, John S K Kauwe, Qingqin Li, Enchi Liu, Fabio Macciardi, Jason H Moore, Leanne Munsie, Kwangsik Nho, Vijay K Ramanan, Shannon L Risacher, David J Stone, Shanker Swaminathan, Arthur W Toga, Michael W Weiner, Andrew J Saykin
The Genetics Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI), formally established in 2009, aims to provide resources and facilitate research related to genetic predictors of multidimensional Alzheimer's disease (AD)-related phenotypes. Here, we provide a systematic review of genetic studies published between 2009 and 2012 where either ADNI APOE genotype or genome-wide association study (GWAS) data were used. We review and synthesize ADNI genetic associations with disease status or quantitative disease endophenotypes including structural and functional neuroimaging, fluid biomarker assays, and cognitive performance...
June 2014: Brain Imaging and Behavior
Jerome A Yesavage, Art Noda, Beatriz Hernandez, Leah Friedman, Jauhtai J Cheng, Jared R Tinklenberg, Joachim Hallmayer, Ruth O'hara, Renaud David, Philippe Robert, Elizabeth Landsverk, Jamie M Zeitzer
OBJECTIVES: One of the hypothesized causes of the breakdown in sleep-wake consolidation often occurring in individuals with Alzheimer disease (AD) is the dysfunction of the circadian clock. The goal of this study is to report indices of sleep-wake function collected from individuals with AD in relation to relevant polymorphisms in circadian clock-related genes. DESIGN: One week of ad libitum ambulatory sleep data collection. SETTING: At-home collection of sleep data and in-laboratory questionnaire...
July 2011: American Journal of Geriatric Psychiatry
Andrew J Saykin, Li Shen, Tatiana M Foroud, Steven G Potkin, Shanker Swaminathan, Sungeun Kim, Shannon L Risacher, Kwangsik Nho, Matthew J Huentelman, David W Craig, Paul M Thompson, Jason L Stein, Jason H Moore, Lindsay A Farrer, Robert C Green, Lars Bertram, Clifford R Jack, Michael W Weiner
The role of the Alzheimer's Disease Neuroimaging Initiative Genetics Core is to facilitate the investigation of genetic influences on disease onset and trajectory as reflected in structural, functional, and molecular imaging changes; fluid biomarkers; and cognitive status. Major goals include (1) blood sample processing, genotyping, and dissemination, (2) genome-wide association studies (GWAS) of longitudinal phenotypic data, and (3) providing a central resource, point of contact and planning group for genetics within the Alzheimer's Disease Neuroimaging Initiative...
May 2010: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Arthur W Toga, Karen L Crawford
The Alzheimer's Diseases Neuroimaging Initiative project has brought together geographically distributed investigators, each collecting data on the progression of Alzheimer's disease. The quantity and diversity of the imaging, clinical, cognitive, biochemical, and genetic data acquired and generated throughout the study necessitated sophisticated informatics systems to organize, manage, and disseminate data and results. We describe, here, a successful and comprehensive system that provides powerful mechanisms for processing, integrating, and disseminating these data not only to support the research needs of the investigators who make up the Alzheimer's Diseases Neuroimaging Initiative cores, but also to provide widespread data access to the greater scientific community for the study of Alzheimer's Disease...
May 2010: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Paul S Aisen, Ronald C Petersen, Michael C Donohue, Anthony Gamst, Rema Raman, Ronald G Thomas, Sarah Walter, John Q Trojanowski, Leslie M Shaw, Laurel A Beckett, Clifford R Jack, William Jagust, Arthur W Toga, Andrew J Saykin, John C Morris, Robert C Green, Michael W Weiner
The Clinical Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has provided clinical, operational, and data management support to ADNI since its inception. This article reviews the activities and accomplishments of the core in support of ADNI aims. These include the enrollment and follow-up of more than 800 subjects in the three original cohorts: healthy controls, amnestic mild cognitive impairment (now referred to as late MCI, or LMCI), and mild Alzheimer's disease (AD) in the first phase of ADNI (ADNI 1), with baseline longitudinal, clinical, and cognitive assessments...
May 2010: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
John Q Trojanowski, Hugo Vandeerstichele, Magdalena Korecka, Christopher M Clark, Paul S Aisen, Ronald C Petersen, Kaj Blennow, Holly Soares, Adam Simon, Piotr Lewczuk, Robert Dean, Eric Siemers, William Z Potter, Michael W Weiner, Clifford R Jack, William Jagust, Arthur W Toga, Virginia M-Y Lee, Leslie M Shaw
Here, we review progress by the Penn Biomarker Core in the Alzheimer's Disease Neuroimaging Initiative (ADNI) toward developing a pathological cerebrospinal fluid (CSF) and plasma biomarker signature for mild Alzheimer's disease (AD) as well as a biomarker profile that predicts conversion of mild cognitive impairment (MCI) and/or normal control subjects to AD. The Penn Biomarker Core also collaborated with other ADNI Cores to integrate data across ADNI to temporally order changes in clinical measures, imaging data, and chemical biomarkers that serve as mileposts and predictors of the conversion of normal control to MCI as well as MCI to AD, and the progression of AD...
May 2010: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
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