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https://www.readbyqxmd.com/read/29473015/molecular-analysis-of-integrons-and-antimicrobial-resistance-profile-in-shigella-spp-isolated-from-acute-pediatric-diarrhea-patients
#1
Mohammad Mehdi Soltan Dallal, Sajjad Omidi, Masoumeh Douraghi, Mohammad Taghi Haghi Ashtiani, Mohammad Kazem Sharifi Yazdi, Arash Okazi
Introduction: Shigella spp. is a growing global health concern due to increasing multiple drug resistance, commonly resulting in therapeutic failure. Integrons are gene expression systems run by integrase genes. The aims of this study were detection of class I, II and III integrons and assessment of antimicrobial resistance in Shigella spp. isolated from acute pediatric diarrhea patients. Materials and methods: From January to December 2015, 16 Shigella spp. were isolated from 310 non-duplicative diarrheal stool samples in Children's Medical Center, Tehran, Iran...
2018: GMS Hygiene and Infection Control
https://www.readbyqxmd.com/read/29472854/altered-connectivity-of-the-anterior-cingulate-and-the-posterior-superior-temporal-gyrus-in-a-longitudinal-study-of-later-life-depression
#2
Kenichiro Harada, Toshikazu Ikuta, Mami Nakashima, Toshio Watanuki, Masako Hirotsu, Toshio Matsubara, Hirotaka Yamagata, Yoshifumi Watanabe, Koji Matsuo
Patients with later-life depression (LLD) show abnormal gray matter (GM) volume, white matter (WM) integrity and functional connectivity in the anterior cingulate cortex (ACC) and posterior superior temporal gyrus (pSTG), but it remains unclear whether these abnormalities persist over time. We examined whether structural and functional abnormalities in these two regions are present within the same subjects during depressed vs. remitted phases. Sixteen patients with LLD and 30 healthy subjects were studied over a period of 1...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29471442/estimation-of-adaptive-ventilation-success-and-failure-using-polysomnogram-and-outpatient-therapy-biomarkers
#3
Stacey Gunn, Sreelatha Naik, Matt Travis Bianchi, Robert Joseph Thomas
Study Objectives: Adaptive servo ventilation (ASV) devices provide anti-cyclic pressure support for treatment of central/complex sleep apnea, including in heart failure patients. Variability in responses in the clinic and negative clinical trials motivated assessment of standard and novel signal biomarkers for ASV efficacy. Methods: Multiple clinical databases were queried to assess potential signal biomarkers of ASV effectiveness, including 1) Attended laboratory adaptive ventilation titrations: 108, of which 66 had mainstream ETCO2 measurements...
February 17, 2018: Sleep
https://www.readbyqxmd.com/read/29471265/role-of-rpos-in-stress-resistance-quorum-sensing-and-spoilage-potential-of-pseudomonas-fluorescens
#4
Xiaoxiang Liu, Lei Ji, Xu Wang, Jianrong Li, Junli Zhu, Aihua Sun
Microorganism activities are considered the main cause of most food spoilage, leading to great economic losses. Pseudomonas fluorescens is a Gram-negative bacterium that is widely found in food and has high spoilage activity. RpoS is considered an important global regulator involved in stress survival and virulence in many pathogens. Thus, it is very possible that RpoS plays an important role in spoilage regulation in P. fluorescens. In this study an in-frame deletion mutation of rpoS was constructed to explore its function in P...
February 14, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29470474/monitoring-pre-hospital-transport-of-severely-injured-patients-in-the-midland-region-of-new-zealand
#5
Jesse Whitehead, Matt Roskruge, Colin Tan, Alistair Smith, Grant Christey
AIM: Pre-hospital triage strategies aim to identify the type and extent of patient injuries and ensure that they are transferred to the most appropriate trauma centres. Despite the importance of appropriate pre-hospital transport, there is little evidence base to assist medical staff on optimal destination policy for emergent pre-hospital transport. This paper explores the spatial relationship of patient transfers prior to the implementation of the Midland Pre-Hospital Trauma Destination Matrix in New Zealand, and is a retrospective view of practice against a destination policy that was applied after the study period...
February 23, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29467493/c-jun-ap-1-overexpression-reprograms-er%C3%AE-signaling-related-to-tamoxifen-response-in-er%C3%AE-positive-breast-cancer
#6
Huan He, Indranil Sinha, Rongrong Fan, Lars-Arne Haldosen, Feifei Yan, Chunyan Zhao, Karin Dahlman-Wright
A critical mechanism that has been proposed for transcription regulation by estrogen receptor α (ER) is the tethering of ER to DNA via other transcription factors, such as AP-1. However, genome-wide assessment of the overlap in chromatin binding repertoires of these two transcription factors has not been reported. Here, we show that the AP-1 transcription factor c-Jun interacts with ER and that c-Jun chromatin binding shows extensive overlap with ER binding at the global level. Further, we show that c-Jun overexpression reprograms ER chromatin binding and modulates ER-mediated gene regulation...
February 22, 2018: Oncogene
https://www.readbyqxmd.com/read/29466785/down-regulation-of-h3k4me3-by-mm-102-facilitates-epigenetic-reprogramming-of-porcine-somatic-cell-nuclear-transfer-embryos
#7
Zhiren Zhang, Yanhui Zhai, Xiaoling Ma, Sheng Zhang, Xinglan An, Hao Yu, Ziyi Li
BACKGROUND/AIMS: Aberrantly high levels of H3K4me3, caused by incomplete epigenetic reprogramming, likely cause a low efficiency of somatic cell nuclear transfer (SCNT). Smal molecule inhibitors aimed at epigenetic modification can be used to improve porcine SCNT embryo development. In this study, we examined the effects of MM-102, an H3K4 histone methyltransferase inhibitor, on porcine SCNT preimplantation embryos to investigate the mechanism by which H3K4 methylation regulated global epigenetic reprograming during SCNT...
February 16, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29466098/comparing-global-positioning-system-gps-and-global-navigation-satellite-system-gnss-measures-of-team-sport-movements
#8
Benjamin M Jackson, Ted Polglaze, Brian Dawson, Trish King, Peter Peeling
PURPOSE: To compare data from conventional GPS and new GNSS-enabled tracking devices, and to examine the inter-unit reliability of GNSS devices. METHODS: Inter-device differences between 10 Hz GPS and GNSS devices were examined during laps (n=40) of a simulated game circuit (SGC) and during elite hockey matches (n=21); GNSS inter-unit reliability was also examined during the SGC laps. Differences in distance values and measures in three velocity categories (low <3 m...
February 21, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29465349/association-of-depression-with-socioeconomic-status-anticardiolipin-antibodies-and-organ-damage-in-patients-with-systemic-lupus-erythematosus-results-from-the-kornet-registry
#9
Dong-Jin Park, Ji-Hyoun Kang, Kyung-Eun Lee, Seong Wook Kang, Seung-Ki Kwok, Seong-Kyu Kim, Jung-Yoon Choe, Hyoun-Ah Kim, Yoon-Kyoung Sung, Kichul Shin, Sang-Il Lee, Chang-Hoon Lee, Sung-Jae Choi, Shin-Seok Lee
OBJECTIVES: Depression is more common in patients with systemic lupus erythematosus (SLE) compared to the general population. However, few studies have investigated risk factors of depression in SLE patients, and the results are inconsistent. This study evaluated the prevalence of, and risk factors for, depression in ethnically homogeneous Korean SLE patients. METHODS: In this study, 505 consecutive SLE patients were enrolled from the Korean Lupus Network registry...
February 14, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29464940/multiplatform-plasma-fingerprinting-in-cancer-cachexia-a-pilot-observational-and-translational-study
#10
Mónica Patricia Cala, María Teresa Agulló-Ortuño, Elena Prieto-García, Carolina González-Riano, Lucía Parrilla-Rubio, Coral Barbas, Carmen Vanesa Díaz-García, Antonia García, Cristina Pernaut, Jorge Adeva, María Carmen Riesco, Francisco Javier Rupérez, Jose Antonio Lopez-Martin
BACKGROUND: Cachexia is a metabolic syndrome that affects up to 50-80% of cancer patients. The pathophysiology is characterized by a variable combination of reduced food intake and abnormal metabolism, including systemic inflammation and negative protein and energy balance. Despite its high clinical significance, defined diagnostic criteria and established therapeutic strategies are lacking. The 'omics' technologies provide a global view of biological systems. We hypothesize that blood-based metabolomics might identify findings in cachectic patients that could provide clues to gain knowledge on its pathophysiology, and eventually postulate new therapeutic strategies...
February 20, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29462929/distributed-water-pollution-source-localization-with-mobile-uv-visible-spectrometer-probes-in-wireless-sensor-networks
#11
Junjie Ma, Fansheng Meng, Yuexi Zhou, Yeyao Wang, Ping Shi
Pollution accidents that occur in surface waters, especially in drinking water source areas, greatly threaten the urban water supply system. During water pollution source localization, there are complicated pollutant spreading conditions and pollutant concentrations vary in a wide range. This paper provides a scalable total solution, investigating a distributed localization method in wireless sensor networks equipped with mobile ultraviolet-visible (UV-visible) spectrometer probes. A wireless sensor network is defined for water quality monitoring, where unmanned surface vehicles and buoys serve as mobile and stationary nodes, respectively...
February 16, 2018: Sensors
https://www.readbyqxmd.com/read/29462326/secreted-frizzled-related-protein-2-sfrp2-expression-promotes-lesion-proliferation-via-canonical-wnt-signaling-and-indicates-lesion-borders-in-extraovarian-endometriosis
#12
T Heinosalo, M Gabriel, L Kallio, P Adhikari, K Huhtinen, T D Laajala, E Kaikkonen, A Mehmood, P Suvitie, H Kujari, T Aittokallio, A Perheentupa, M Poutanen
STUDY QUESTION: What is the role of SFRP2 in endometriosis? SUMMARY ANSWER: SFRP2 acts as a canonical WNT/CTNNB1 signaling agonist in endometriosis, regulating endometriosis lesion growth and indicating endometriosis lesion borders together with CTNNB1 (also known as beta catenin). WHAT IS KNOWN ALREADY: Endometriosis is a common, chronic disease that affects women of reproductive age, causing pain and infertility, and has significant economic impact on national health systems...
February 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29461992/healthcare-s-future-strategic-investment-in-technology
#13
Michael A Franklin
Recent and rapid advances in the implementation of technology have greatly affected the quality and efficiency of healthcare delivery in the United States. Simultaneously, diverse generational pressures-including the consumerism of millennials and unsustainable growth in the costs of care for baby boomers-have accelerated a revolution in healthcare delivery that was marked in 2010 by the passage of the Affordable Care Act.Against this backdrop, Maryland and the Centers for Medicare & Medicaid Services entered into a partnership in 2014 to modernize the Maryland All-Payer Model...
April 2018: Frontiers of Health Services Management
https://www.readbyqxmd.com/read/29461806/white-light-emission-from-layered-halide-perovskites
#14
Matthew D Smith, Hemamala I Karunadasa
With nearly 20% of global electricity consumed by lighting, more efficient illumination sources can enable massive energy savings. However, effectively creating the high-quality white light required for indoor illumination remains a challenge. To accurately represent color, the illumination source must provide photons with all the energies visible to our eye. Such a broad emission is difficult to achieve from a single material. In commercial white-light sources, one or more light-emitting diodes, coated by one or more phosphors, yield a combined emission that appears white...
February 20, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29461496/online-aerial-terrain-mapping-for-ground-robot-navigation
#15
John Peterson, Haseeb Chaudhry, Karim Abdelatty, John Bird, Kevin Kochersberger
This work presents a collaborative unmanned aerial and ground vehicle system which utilizes the aerial vehicle's overhead view to inform the ground vehicle's path planning in real time. The aerial vehicle acquires imagery which is assembled into a orthomosaic and then classified. These terrain classes are used to estimate relative navigation costs for the ground vehicle so energy-efficient paths may be generated and then executed. The two vehicles are registered in a common coordinate frame using a real-time kinematic global positioning system (RTK GPS) and all image processing is performed onboard the unmanned aerial vehicle, which minimizes the data exchanged between the vehicles...
February 20, 2018: Sensors
https://www.readbyqxmd.com/read/29461418/influence-of-biological-maturity-on-the-match-performance-of-8-to-16-year-old-elite-male-youth-soccer-players
#16
Heita Goto, John G Morris, Mary E Nevill
The aim of this study was to examine the influence of biological maturity on match performance in elite youth male soccer players. The participants were 80 Premier League Academy outfield players (8-16 years old). Biological maturity was determined by calculating estimated chronological age at peak height velocity. The U9 and U10 squads played 6-a-side and the U11-U16 squads played 11-a-side inter-academy matches. All matches were analyzed using a 1 Hz Global Positioning System (SPI elite, GPSport, Australia) with squad specific speed zones which were calculated based on 5 m flying sprint speed in the last 5 m of 10 m sprint test...
February 14, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29458404/a-novel-integrated-care-concept-nicc-versus-standard-care-in-the-treatment-of-chronic-cardiovascular-diseases-protocol-for-the-randomized-controlled-trial-cardiocare-mv
#17
Christian Schmidt, Alper Öner, Miriam Mann, Katja Krockenberger, Melanie Abbondanzieri, Bernard Brandewiede, Armin Brüge, Gisela Hostenkamp, Axel Kaiser, Henriette Neumeyer, Andreas Ziegler
BACKGROUND: Cardiovascular diseases are the major cause of death globally and represent a major economic burden on health care systems. Positive effects of disease management programs have been shown for patients with heart failure (HF). Remote monitoring and telemonitoring with active intervention are beneficial in atrial fibrillation (AF) and therapy-resistant hypertension (TRH), respectively. For these patients, we have developed a novel integrated care concept (NICC) which combines telemedicine with intensive support by a care center, including a call center, an integrated care network including inpatient and outpatient care providers and guideline therapy for patients...
February 20, 2018: Trials
https://www.readbyqxmd.com/read/29458245/impact-of-sleep-quality-on-clinical-features-of-primary-sj%C3%A3-gren-s-syndrome
#18
Sang Wan Chung, Jaehyung Hur, You-Jung Ha, Eun Ha Kang, Joon Young Hyon, Hyo-Jung Lee, Yeong Wook Song, Yun Jong Lee
Background/Aims: This study aimed to investigate the inf luence of poor sleep quality on clinical features of primary Sjögren's syndrome (pSS). Methods: Sleep quality was cross-sectionally assessed using the Pittsburgh Sleep Quality Index (PSQI), and demographic, clinical, and laboratory data were collected from 115 Korean patients with pSS. The patients completed questionnaires on the European League Against Rheumatism (EULAR) SS Patient Reported Index (ESSPRI), quality of life (EuroQOL five dimensions questionnaire [EQ-5D]), fatigue (fatigue severity score [FSS]), and depression (Beck Depression Inventory [BDI] II])...
February 20, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29457624/-coordinated-heart-failure-care-in-poland-towards-optimal-organisation-of-the-health-care-system
#19
Jadwiga Nessler, Adam Kozierkiewicz, Andrzej Gackowski, Piotr Ponikowski, Ewa Straburzynska-Migaj, Izabella Uchmanowicz, Piotr Hoffman, Krzysztof Chlebus, Grzegorz Gielerak, Mariusz Gąsior, Tomasz Grodzicki, Jakub Gierczyński, Piotr Jankowski, Jarosław Kaźmierczak, Jacek Legutko, Przemysław Leszek, Maciej Miłkowski, Grzegorz Opolski, Piotr Rozentryt, Adam Windak, Adam Witkowski, Mirosław J Wysocki, Andrzej Zapaśnik, Tomasz Zdrojewski
Heart failure has becoming an increasing medical, economic, and social problem globally. The prevalence of this syndrome is rising, and despite unequivocal positive effects of modern therapy, reduction of mortality has been achieved at the cost of more frequent hospitalisations. Unlike in many European countries, in Poland heart failure is usually recognised later, at a more advanced stage of the disease, leaving less time for ambulatory treatment and resulting in a high number of hospitalisations. The current paper presents the most important data regarding morbidity and mortality due to heart failure in Poland...
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29448480/quantum-thermodynamics-from-the-nonequilibrium-dynamics-of-open-systems-energy-heat-capacity-and-the-third-law
#20
J-T Hsiang, C H Chou, Y Subaşı, B L Hu
In a series of papers, we intend to take the perspective of open quantum systems and examine from their nonequilibrium dynamics the conditions when the physical quantities, their relations, and the laws of thermodynamics become well defined and viable for quantum many-body systems. We first describe how an open-system nonequilibrium dynamics (ONEq) approach is different from the closed combined system + environment in a global thermal state (CGTs) setup. Only after the open system equilibrates will it be amenable to conventional thermodynamics descriptions, thus quantum thermodynamics (QTD) comes at the end rather than assumed in the beginning...
January 2018: Physical Review. E
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