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https://www.readbyqxmd.com/read/29755804/sapho-syndrome-masquerading-as-metastatic-breast-cancer
#1
Devin Malik, Richa Handa, Andrew Petraszko, Sheela Tejwani
SAPHO syndrome is a rare clinical entity composed of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO). We describe a case of SAPHO syndrome masquerading as metastatic breast cancer in a patient with localized breast cancer who presented with cord compression. There was no pathologic evidence of metastatic cancer; however, a bone scan indicated osseous involvement. After multidisciplinary review of images and with additional findings of pustulosis and acne, a clinical diagnosis of SAPHO was made...
2018: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/29743324/spondyloarthritis-in-the-democratic-republic-of-the-congo-a-prospective-hospital-based-study
#2
Pierrot Lebughe, Kurt de Vlam, Rene Westhovens, Jean-Marie Mbuyi-Muamba, Jean Jacques Malemba
OBJECTIVES: To determine the spectrum of spondyloarthritis (SpA) in outpatients with symptoms of rheumatism attending two rheumatology practices in the Democratic Republic of the Congo. DESIGN: A descriptive prospective multicentre outpatient study. SETTING: The present study analysed 6 months data (from 1 December 2012 till 31 May 2013). PARTICIPANTS: Nine hundred and eighty-four consecutive outpatients were studied...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29740589/cervical-hyperostosis-leading-to-dyspnea-aspiration-and-dysphagia-strategies-to-improve-patient-management
#3
Georgios Psychogios, Monika Jering, Johannes Zenk
Diffuse idiopathic skeletal hyperostosis (DISH) is a rare but well known cause of dysphagia. In very few cases aspiration and dyspnea are described as a clinical manifestation. An 82-year-old man presented himself in our clinic with severe dyspnea, aspiration, and pneumonia. After performing a microlaryngoscopy an emergency tracheotomy became necessary. In laryngoscopy a severe bulging of the posterior oropharyngeal and hypopharyngeal wall was detected. The glottis area was not observable and immobilisation of the right vocal cord could be detected...
2018: Frontiers in Surgery
https://www.readbyqxmd.com/read/29734937/primary-skull-base-lymphoma-manifestations-and-clinical-outcomes-of-a-great-imitator
#4
John P Marinelli, Mara C Modzeski, John I Lane, Jamie J Van Gompel, Janalee K Stokken, Gita Thanarajasingam, Matthew L Carlson
Objectives Primary skull base lymphoma (PSBL) represents a rare manifestation of extranodal lymphoma. Presenting with nonspecific symptomatology and imaging findings, PSBL often masquerades as more common cranial base pathology and thus can present a diagnostic challenge. The objectives of this study were to characterize the manifestations and clinical outcomes of PSBL. Study Design Case series and chart review. Setting Tertiary referral center. Subjects and Methods Review of 48 patients with PSBL treated between 1994 and 2016...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29729471/meningioma-and-bone-hyperostosis-expression-of-bone-stimulating-factors-and-review-of-the-literature
#5
Andrea Di Cristofori, Massimiliano Del Bene, Marco Locatelli, Francesca Boggio, Giulia Ercoli, Stefano Ferrero, Alessandro Del Gobbo
OBJECTIVE: Several hypothesis have been proposed in order to understand the mechanisms underlying the meningioma related hyperostosis. Objective of our study was to investigate the role of osteoprotegerin(OPG), insulin-like growth factor-1(IGF-1), endothelin-1(ET-1), Bone Morphogenetic Protein(BMP-2 and -4). METHODS: A total of 149 patients (39 males and 110 females with a mean age of 62 years) that received surgery were included. Depending on the relationship with the bone, meningiomas were classified in hyperostotic, osteolytic, infiltrative and without relation with the bone...
May 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29718882/severe-hip-joint-motion-restriction-in-a-patient-with-diffuse-idiopathic-skeletal-hyperostosis-a-case-report
#6
Wonho Lee, Wook Ro Kim, Min Cheol Chang
RATIONALE: Severe limitation of motion (LOM) in the spine occasionally occurs in patients with diffuse idiopathic skeletal hyperostosis (DISH). However, in extraspinal areas, significant LOM has rarely been reported. In this study, we report a patient with DISH who had severe motion restriction within both hip joints. PATIENT CONCERNS: A 57-year-old man presented with a 10-year history of LOM of bilateral hip joints. He had gait difficulty due to shortened stride length induced by LOM...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29710019/-parkinson-s-disease-associated-with-sapho-syndrome-a-case-report
#7
Takashi Ando, Amane Araki, Shinichi Terao, Masahisa Katsuno
A 77-year-old woman with Parkinson's disease presented with left chest pain. Physical examination revealed tenderness at her second left sternocostal joint. There was no skin rash. Chest CT revealed hyperostosis of the sternocostal joint, and cervical MRI showed vertebral osteosclerosis and osteolysis. 99mTc-MDP bone scintigraphy showed an increased activity in the sternocostal joint and vertebral column. The patient was diagnosed with SAHPO syndrome according to the diagnostic criteria. Her chest pain was relieved after oral administration of nonsteroidal anti-inflammatory drugs...
April 28, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29709743/a-case-report-of-worth-syndrome-and-chiari-i-malformation-unusual-association-and-surgical-treatment
#8
Martin Andres Merenzon, Matias Agustin Dorman, Pablo Zuliani Sampaolesi, Pablo Alejandro Seoane, Fernando Latorre, Eduardo Roberto Seoane
BACKGROUND: Worth syndrome or Autosomal Dominant Endosteal Hyperostosis (ADEH) is an extremely rare genetic disease involving increased bone density. To the author's knowledge, this is the second case report of a family with neurological involvement associated with this condition along with its surgical treatment. The most effective treatment for clinically significant neurological symptoms in this scenario is currently unknown and there is very sparse experience on surgical treatment for this condition reported in the literature...
April 27, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29701101/thoracic-aortic-aneurysm-is-an-independent-factor-associated-with-diffuse-idiopathic-skeletal-hyperostosis
#9
M Uehara, J Takahashi, S Ikegami, S Kuraishi, D Fukui, H Imamura, K Okada, H Kato
Aims Although we often encounter patients with an aortic aneurysm who also have diffuse idiopathic skeletal hyperostosis (DISH), there are no reports to date of an association between these two conditions and the pathogenesis of DISH remains unknown. This study therefore evaluated the prevalence of DISH in patients with a thoracic aortic aneurysm (AA). Patients and Methods The medical records of 298 patients who underwent CT scans for a diagnosis of an AA or following high-energy trauma were retrospectively examined...
May 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29694253/serum-levels-of-proinflammatory-antiinflammatory-cytokines-and-rankl-opg-in-synovitis-acne-pustulosis-hyperostosis-and-osteitis-sapho-syndrome
#10
Shuo Zhang, Chen Li, Siya Zhang, Li Li, Weihong Zhang, Zhenhua Dong, Wen Zhang
Objective To measure the expression of proinflammatory, antiinflammatory cytokines, and RANKL/OPG in SAPHO Syndrome, and to assess the relationship between those factors and disease activity. Methods We studied 30 cases of SAPHO syndrome and 15 healthy controls. According to the visual analogue scale pain scores and Bath ankylosing spondylitis activity index, patients were divided into active group and stable group. The serum levels of IFN-γ, TNF-α, TGF-β1, IL-1β, IL-4, IL-6, IL-8, IL-17A, IL-22, receptor activator NK-κB ligand (RANKL) and osteoprotegerin (OPG) were determined by ELISA...
April 25, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29682378/simultaneous-bilateral-quadriceps-tendon-rupture-in-a-patient-with-diffuse-idiopathic-skeletal-hyperostosis-after-minimal-trauma-eight-year-follow-up
#11
Sevan Sıvacıoğlu, Ahmet Salduz, Ufuk Öztürk, Serkan Bayram, Fevzi Birişik
Introduction: The purpose of this report was to describe a very rare case of simultaneous bilateral quadriceps tendon rupture seen in a patient who was diagnosed as having diffuse idiopathic skeletal hyperostosis. Case Presentation: A man aged 64 years presented to the emergency department with bilateral quadriceps tendon rupture. Surgical repair was performed with suture anchors and a stainless steel cable. His legs were immobilized in casts for six weeks. After removal of the casts, physiotherapy was started...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29681837/unusual-case-of-vogt-koyanagi-harada-disease-associated-with-sapho-syndrome-a-case-report
#12
Miyuki Hasegawa, Akira Fukutomi, Akiko Jinno, Kyoko Fujita, Motohiro Kamei
A 66-year-old Japanese woman who was diagnosed with synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome presented with bilateral blurred vision 4 months prior to visiting our hospital. She had visited a local ophthalmology clinic first. She was diagnosed with conjunctivitis and was prescribed antibacterial eye drops. The symptoms persisted in spite of treatment. She was then referred to our hospital. At her initial visit, the visual acuities were 0.6 in both eyes. A slit-lamp examination revealed bilateral shallow anterior chamber, and intraocular pressures of 18 mm Hg in the right eye and 16 mm Hg in the left eye...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29672992/life-in-the-fast-lane-settled-pastoralism-in-the-central-eurasian-steppe-during-the-middle-bronze-age
#13
Margaret A Judd, Jessica L Walker, Alicia Ventresca Miller, Dmitry Razhev, Andrey V Epimakhov, Bryan K Hanks
OBJECTIVES: We tested the hypothesis that the purported unstable climate in the South Urals region during the Middle Bronze Age (MBA) resulted in health instability and social stress as evidenced by skeletal response. METHODS: The skeletal sample (n = 99) derived from Kamennyi Ambar 5 (KA-5), a MBA kurgan cemetery (2040-1730 cal. BCE, 2 sigma) associated with the Sintashta culture. Skeletal stress indicators assessed included cribra orbitalia, porotic hyperostosis, dental enamel hypoplasia, and tibia periosteal new bone growth...
April 19, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29672809/sapho-and-crmo-the-value-of-imaging
#14
Anne Grethe Jurik, Rikke Fuglsang Klicman, Paolo Simoni, Philip Robinson, James Teh
The syndromes synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) and chronic recurrent multifocal osteomyelitis (CRMO) constitute a group of chronic relapsing inflammatory osteoarticular disorders with frequently associated skin eruptions such as palmoplantar pustulosis and acne conglobata and rather characteristic imaging features in the form of osteitis and/or hyperostosis. CRMO predominantly occurs in children/adolescents and SAPHO in adults. Any skeletal site can be involved, and the imaging appearances vary, depending on the patient's age and the stage/age of the lesion...
April 2018: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29672561/rich-table-but-short-life-diffuse-idiopathic-skeletal-hyperostosis-in-danish-astronomer-tycho-brahe-1546-1601-and-its-possible-consequences
#15
Sacha Kacki, Petr Velemínský, Niels Lynnerup, Sylva Kaupová, Alizé Lacoste Jeanson, Ctibor Povýšil, Martin Horák, Jan Kučera, Kaare Lund Rasmussen, Jaroslav Podliska, Zdeněk Dragoun, Jiří Smolík, Jens Vellev, Jaroslav Brůžek
The exhumation of Danish astronomer Tycho Brahe (1546-1601) was performed in 2010 to verify speculative views on the cause of his death. Previous analyses of skeletal and hair remains recovered from his grave refuted the presumption that he died from poisoning. These studies also outlined the possibility that he actually died from an acute illness, echoing the rather vague and inaccurate testimony of some historical records. We performed a detailed paleopathological analysis of Tycho Brahe's skeletal remains, along with a reconstruction of his diet based on carbon and nitrogen stable isotopes analysis and an estimate of his physical status (relative body fat) based on medullar and cortical dimensions of the femoral shaft...
2018: PloS One
https://www.readbyqxmd.com/read/29667228/the-anterior-longitudinal-ligament-in-diffuse-idiopathic-skeletal-hyperostosis-ossified-or-displaced
#16
Jonneke S Kuperus, Esther Jm Smit, Behdad Pouran, Robbert W van Hamersvelt, Marijn van Stralen, Peter R Seevinck, Constantinus F Buckens, Ronald Law Bleys, Harrie H Weinans, F Cumhur Oner, Pim A de Jong, Jorrit-Jan Verlaan
Diffuse idiopathic skeletal hyperostosis (DISH) is often theorized to be an ossification of the anterior longitudinal ligament (ALL). Using computed tomography (CT) imaging and cryomacrotome sectioning we investigated the spatial relationship between the ALL and newly formed bone in DISH to test this hypothesis. In the current study, four human cadaveric spines diagnosed with DISH using CT imaging were frozen and sectioned using a cryomacrotome. Photographs were obtained of the specimen at 125µm intervals...
April 17, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29660408/expansion-of-the-clinical-spectrum-of-frontometaphyseal-dysplasia-2-caused-by-the-recurrent-mutation-p-pro485leu-in-map3k7
#17
Alice Costantini, Carina Wallgren-Pettersson, Outi Mäkitie
Frontometaphyseal dysplasia 2 (FMD2) is a skeletal dysplasia with supraorbital hyperostosis combined with undermodeling of the bones, joint contractures and some extraskeletal features. It is caused by heterozygous mutations in MAP3K7, encoding the Mitogen-Activated Protein 3-Kinase 7. MAP3K7 is activated by TGF-β and plays an important role in osteogenesis. Less than 20 patients with FMD2 and MAP3K7 mutations have been described thus far. The majority of the patients harbor a recurrent missense mutation, NM_003188...
April 13, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29657149/the-natural-course-of-diffuse-idiopathic-skeletal-hyperostosis-in-the-thoracic-spine-of-adult-males
#18
Jonneke S Kuperus, Constantinus F Buckens, Jurica Šprem, F Cumhur Oner, Pim A de Jong, Jorrit-Jan Verlaan
OBJECTIVE: Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by flowing bony bridges on the right side of the spine. Knowledge of the development of these spinal bridges is limited. The current longitudinal computed tomography (CT) study was designed to bridge this gap. METHODS: Chest CT scans from elderly males with 2 scans (interval ≥ 2.5 yrs) were retrospectively included. Using the Resnick criteria, a pre-DISH group and a definite DISH group were identified...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29656630/etiopathogenesis-of-traumatic-spinal-epidural-hematoma
#19
Francesco Ciro Tamburrelli, Maria Concetta Meluzio, Giulia Masci, Andrea Perna, Aaron Burrofato, Luca Proietti
Spinal epidural hematoma (SEH) is a rare cause of nerve root or cord compression; its pathogenesis is not always clearly recognizable. The aim of this paper was to investigate possible etiopathological factors in a consecutive series of patients affected by traumatic SEH treated at our institution. Seven patients with neurologic impairment due to traumatic SEH were retrospectively analyzed after diagnosis and surgical treatment. Thoracic localization was found in 5 cases, and lumbar and cervical localization were found in 1 patient each...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29649655/bone-mineral-density-changes-over-time-in-diffuse-idiopathic-skeletal-hyperostosis-of-the-thoracic-spine
#20
Jonneke S Kuperus, Lima Samsour, Constantinus F Buckens, F Cumhur Oner, Pim A de Jong, Jorrit-Jan Verlaan
Diffuse idiopathic skeletal hyperostosis (DISH) is an increasingly prevalent ankylosing condition. Patients with DISH have an increased risk of spinal fractures, hypothetically the result of biomechanical changes in the spine. The aim of this study was to analyze the occurrence of biomechanical stress shielding in patients with DISH. To do this, bone mineral density (BMD) was measured longitudinally in the vertebral bodies of subjects with and without DISH and in the newly formed bone of subjects with DISH...
April 9, 2018: Bone
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