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acta neuropathologica

Nicholas Willard, Bette K Kleinschmidt-DeMasters
BACKGROUND: Recent autopsy data suggests a high incidence of leptomeningeal metastases (LM), Acta Neuropathologica 2014; 128: 573 and subventricular spread (SVS), Acta Neuropathologica 2014; 127: 605 in pediatric diffuse intrinsic pontine gliomas, but both LM and SVS also occur in adult glioblastoma (GBM). Autopsy is required to fully appreciate this tumor behavior. METHODS: From January 1, 2014 to January 3, 2015 we conducted 239 adult autopsies, 8 of which were identified on search to be GBMs...
November 2015: Clinical Neuropathology
Hubert Korr, Nicholas B Angstman, Tatjana B Born, Kerstin Bosse, Birka Brauns, Martin Demmler, Katja Fueller, Orsolya Kántor, Barbara M Kever, Navida Rahimyar, Sepideh Salimi, Jiri Silny, Christoph Schmitz
BACKGROUND: It has been hypothesized in the literature that exposure to extremely low frequency electromagnetic fields (50 or 60 Hz) may lead to human health effects such as childhood leukemia or brain tumors. In a previous study investigating multiple types of cells from brain and kidney of the mouse (Acta Neuropathologica 2004; 107: 257-264), we found increased unrepaired nuclear DNA single strand breaks (nDNA SSB) only in epithelial cells of the choroid plexus in the brain using autoradiographic methods after a continuous eight-week 50 Hz magnetic field (MF) exposure of adult mice with flux density of 1...
2014: PloS One
Jill G Farmer, Barbara J Crain, Brent T Harris, R Scott Turner
Frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) is one of the most common pathological findings associated with the clinical FTLD syndromes. However, molecular characterization with genetic sequencing and protein expression techniques are recognizing many new subtypes for FTLDs. FTLDs are diverse and new nomenclature schemes have been proposed based on the molecular defects that are being discovered ( Mackenzie et al., 2010 , Acta Neuropathologica, 119, 1). Adult polyglucosan body disease (APBD) is a very rare disorder associated with systemic neurological signs and symptoms including progressive dementia with executive dysfunction and motor neuron disease...
2013: Neurocase
Werner Paulus, Kurt A Jellinger
No abstract text is available yet for this article.
May 2011: Acta Neuropathologica
Werner Paulus
No abstract text is available yet for this article.
March 2008: Acta Neuropathologica
Werner Paulus
No abstract text is available yet for this article.
February 2008: Acta Neuropathologica
Johann Steiner, Hendrik Bielau, Ralf Brisch, Peter Danos, Oliver Ullrich, Christian Mawrin, Hans-Gert Bernstein, Bernhard Bogerts
OBJECTIVES: Suicide has a high prevalence in patients with schizophrenia and affective disorder. Our recent postmortem study [Steiner J, Mawrin C, Ziegeler A, Bielau H, Ullrich O, Bernstein HG, Bogerts B. Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralization. Acta Neuropathologica (Berl) 2006;112:305-16.] revealed increased microglial densities in two schizophrenic patients who had committed suicide. Therefore, the hypothesis of microglial activation during acute psychosis was proposed...
January 2008: Journal of Psychiatric Research
V J Hinton, W T Brown, K Wisniewski, R D Rudelli
Fragile X [fraX] syndrome is a common hereditary disorder associated with a fragile site marker at Xq27.3 which clinically presents as a form of mental retardation (MR). Postmortem investigation of 3 fraX positive males with mild to moderate MR did not document any gross neuropathological changes. Golgi analysis of neocortical dendritic spine morphology extended our previous observations of immature, long, tortuous spines in one adult case of fraX (Rudelli, et al., Acta Neuropathologica 67:289-295, 1985) to 2 new cases...
December 1, 1991: American Journal of Medical Genetics
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