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JOURNAL ARTICLE
Xiangming Xu, Chi Xiao, Ming Yi, Jing Yang, Mengshi Liao, Kun Zhou, Liuting Hu, Fubing Ouyang, Linfang Lan, Yuhua Fan
Hypertension is a leading cause of cerebral small vessel disease (CSVD) and vascular dementia in elderly individuals. We aimed to assess cerebral perfusion and dynamic changes in brain structure in stroke-prone renovascular hypertensive rats (RHRSPs) with different durations of hypertension and to investigate whether they have pathophysiological features similar to those of humans with CSVD. The RHRSP model was established using the two-kidney, two-clip (2k2c) method, and the Morris water maze (MWM) test, MRI, immunohistochemistry, and biochemical analysis were performed at multiple time points for up to six months following the 2k2c operation...
March 5, 2024: Translational Stroke Research
#22
JOURNAL ARTICLE
Qijin Wang, Cuihua Yuan, Zhixiong Zheng, Caihua Chen, Xiao Zhan, Xiaodan Lin
OBJECTIVE: Cerebral small vessel disease (CSVD) is the most common vascular cause of cognitive impairment. This study aimed to explore the association between MTHFR C677T polymorphism and cognitive impairment in CSVD patients. METHODS: Demographic, medical, laboratory, cognitive evaluation, and MTHFR C677T polymorphism data were collected from CSVD patients admitted to our hospital between January 2019 and July 2023. Inclusion criteria for CSVD were based on the Standards for Reporting Vascular changes on Neuroimaging (STRIVE) criteria, with age ≥ 45 years...
2024: Frontiers in Aging Neuroscience
#23
JOURNAL ARTICLE
A Pascarella, L Manzo, O Marsico, S Gasparini, E Falcone, S Cammaroto, U Sabatini, U Aguglia, E Ferlazzo
BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal dominantly inherited cerebral small vessel disease caused by Neurogenic locus notch homolog protein 3 (NOTCH3) gene mutations. The main clinical features include migraine with aura, recurrent ischemic strokes and dementia. Brain MRI typically shows multiple small lacunar infarcts and severe, diffuse, symmetrical white matter hyperintensities (WMHs), with characteristic involvement of the anterior temporal pole, external capsule, and superior frontal gyrus...
February 2024: European Review for Medical and Pharmacological Sciences
#24
JOURNAL ARTICLE
Jing Du, Yuangang Pan, Jiyang Jiang, Ben C P Lam, Anbupalam Thalamuthu, Rory Chen, Ivor W Tsang, Perminder S Sachdev, Wei Wen
As the brain ages, it almost invariably accumulates vascular pathology, which differentially affects the cerebral white matter. A rich body of research has investigated the link between vascular risk factors and the brain. One of the less studied questions is that among various modifiable vascular risk factors, which is the most debilitating one for white matter health? A white matter specific brain age was developed to evaluate the overall white matter health from diffusion weighted imaging, using a three-dimensional convolutional neural network deep learning model in both cross-sectional UK biobank participants (n = 37,327) and a longitudinal subset (n = 1409)...
February 29, 2024: European Archives of Psychiatry and Clinical Neuroscience
#25
JOURNAL ARTICLE
Gemma Solé-Guardia, Matthijs Luijten, Bram Geenen, Jurgen A H R Claassen, Geert Litjens, Frank-Erik de Leeuw, Maximilian Wiesmann, Amanda J Kiliaan
White matter hyperintensities (WMH) are the most prevalent markers of cerebral small vessel disease (SVD), which is the major vascular risk factor for dementia. Microvascular pathology and neuroinflammation are suggested to drive the transition from normal-appearing white matter (NAWM) to WMH, particularly in individuals with hypertension. However, current imaging techniques cannot capture ongoing NAWM changes. The transition from NAWM into WMH is a continuous process, yet white matter lesions are often examined dichotomously, which may explain their underlying heterogeneity...
February 29, 2024: Scientific Reports
#26
JOURNAL ARTICLE
L Gaillard, M C Tjaberinga, M H G Dremmen, I M J Mathijssen, H A Vrooman
Metopic synostosis patients are at risk for neurodevelopmental disorders despite a negligible risk of intracranial hypertension. To gain insight into the underlying pathophysiology of metopic synostosis and associated neurodevelopmental disorders, we aimed to investigate brain volumes of non-syndromic metopic synostosis patients using preoperative MRI brain scans. MRI brain scans were processed with HyperDenseNet to calculate total intracranial volume (TIV), total brain volume (TBV), total grey matter volume (TGMV), total white matter volume (TWMV) and total cerebrospinal fluid volume (TCBFV)...
February 28, 2024: Journal of Anatomy
#27
JOURNAL ARTICLE
Aleksi Tarkkonen, Ward Fickweiler, Marika Eriksson, Jennifer K Sun, Lena M Thorn, Paula Summanen, Per-Henrik Groop, Jukka Putaala, Juha Martola, Daniel Gordin
OBJECTIVES: A third of asymptomatic individuals with type 1 diabetes (T1D) show signs of cerebrovascular disease in brain MRI. These signs associate with advanced stages of diabetic retinal disease, but not in mild or moderate retinopathy. We aimed to evaluate a wider spectrum of retinal changes by exploring the relationship between quantitative measures of retinal vessel parameters (RVP) and cerebrovascular changes in T1D. METHODS: We included 146 neurologically asymptomatic individuals with T1D [51% women, median age 40 (33...
February 28, 2024: Journal of Hypertension
#28
JOURNAL ARTICLE
Atef Badji, Nira Cedres, J-Sebastian Muehlboeck, Wasim Khan, Thijs Dhollander, Jose Barroso, Daniel Ferreira, Eric Westman
BACKGROUND: Age-related cognitive decline is linked to changes in the brain, particularly the deterioration of white matter (WM) microstructure that accelerates after the age of 60. WM deterioration is associated with mild cognitive impairment and dementia, but the origin and role of white matter signal abnormalities (WMSA) seen in standard MRI remain debated due to their heterogeneity. This study explores the potential of single-shell 3-tissue constrained spherical deconvolution (SS3T-CSD), a novel technique that models diffusion data in terms of gray matter (TG ), white matter (Tw ), and cerebrospinal fluid (TC ), to differentiate WMSA from normal-appearing white matter and better understand the interplay between changes in WM microstructure and decline in cognition...
March 2024: Human Brain Mapping
#29
JOURNAL ARTICLE
Sera Kasai, Keita Watanabe, Satoru Ide, Yuka Ishimoto, Miho Sasaki, Yoshihito Umemura, Soichiro Tatsuo, Sachi Kakeda, Tatsuya Mikami, Yoshinori Tamada, Yasuo Miki, Koichi Wakabayashi, Masahiko Tomiyama, Shingo Kakeda
RATIONALE AND OBJECTIVES: Although hyperintensity in the anterior portion of the callosal splenium on FLAIR (aCS-hyperintensity) is a common finding in elderly adults, no previous studies have examined the clinical significance. In this large elderly population study, we aimed to investigate the associations of aCS-hyperintensity with vascular risk factors, cognitive decline, and other MRI measurements. MATERIALS AND METHODS: This cross-sectional study included 2110 participants (median age, 69 years; 61...
February 26, 2024: Academic Radiology
#30
REVIEW
Yu-Tong Liu, Chun-Yan Lei, Lian-Mei Zhong
OBJECTIVE: The purpose of this review is to identify the correlation between ICH and CSVD imaging markers under SMASH-U classification by searching and analyzing a large number of literatures in recent years, laying a theoretical foundation for future clinical research. At the same time, by collecting clinical data to evaluate patient prognosis, analyzing whether there are differences or supplements between clinical trial conclusions and previous theories, and ultimately guiding clinical diagnosis and treatment through the analysis of imaging biomarkers...
2024: Neuropsychiatric Disease and Treatment
#31
JOURNAL ARTICLE
Braydon Dymm, Larry B Goldstein, Shakthi Unnithan, Hussein R Al-Khalidi, Deborah Koltai, Cheryl Bushnell, Nada El Husseini
OBJECTIVES: We sought to examine the frequency of depression after small vessel-type stroke (SVS) and associated risk factors. MATERIALS AND METHODS: We conducted a retrospective analysis of a prospective cohort of patients enrolled in the American Stroke Association-Bugher SVS Study, which included 200 participants within 2-years of SVS and 79 controls without a history of stroke from 2007 to 2012 at four sites. The primary outcome was PHQ-8, with scores ≥10 consistent with post-stroke depression (PSD)...
February 21, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#32
JOURNAL ARTICLE
Rayan Anbar, Siana Jones, Nish Chaturvedi, Carole Sudre, Marcus Richards, Salahaden R Sultan, Alun D Hughes
BACKGROUND: Cognitive function has an important role in determining the quality of life of older adults. Cardiovascular disease (CVD) is common in older people and may compromise cognitive performance; however, the extent to which this is related to carotid atherosclerosis is unclear. AIM: We investigated associations between carotid atherosclerosis and cognitive function and neuroimaging markers of brain health in a UK multi-ethnic community-based sample including older people of European, South Asian, and African-Caribbean ethnicity...
March 2024: Atheroscler Plus
#33
JOURNAL ARTICLE
Weiyi Zhong, Yiwei Xia, Yunqing Ying, Yi Wang, Lumeng Yang, Xiaoniu Liang, Qianhua Zhao, Jianjun Wu, Zonghui Liang, Xiaoxiao Wang, Xin Cheng, Ding Ding, Qiang Dong
BACKGROUND: Cerebral pulsatility is thought to reflect arterial stiffness and downstream microvascular resistance. Although previous studies indicated cerebral pulsatility might closely relate to development of cerebral small vessel disease (SVD), yet evidence remain controversial and longitudinal data are rare. OBJECTIVE: We aimed to explore relationships of cerebral pulsatility with severity and progression of various SVD imaging markers among the community-dwelling elderly...
2024: Therapeutic Advances in Neurological Disorders
#34
JOURNAL ARTICLE
Alexandra Rhally, Giulia Bommarito, Marjolaine Uginet, Gautier Breville, Patrick Stancu, Alice Accorroni, Frédéric Assal, Patrice H Lalive, Karl-Olof Lövblad, Gilles Allali
OBJECTIVES: Acute encephalopathy (AE) has been described as a severe complication of COVID-19. Inflammation has been suggested as a pathogenic mechanism, with high-dose glucocorticoids (GC) showing a beneficial effect. Here, we retrospectively analyzed the clinical and radiological features in a group of COVID-19 AE patients who received GC treatment (GT) and in a non-treated (NT) group. METHOD: Thirty-six patients with COVID-19 AE (mean age 72.6 [Formula: see text] 11 years; 86...
February 16, 2024: Journal of Neural Transmission
#35
JOURNAL ARTICLE
Ioanna Skampardoni, Ilya M Nasrallah, Ahmed Abdulkadir, Junhao Wen, Randa Melhem, Elizabeth Mamourian, Guray Erus, Jimit Doshi, Ashish Singh, Zhijian Yang, Yuhan Cui, Gyujoon Hwang, Zheng Ren, Raymond Pomponio, Dhivya Srinivasan, Sindhuja Tirumalai Govindarajan, Paraskevi Parmpi, Katharina Wittfeld, Hans J Grabe, Robin Bülow, Stefan Frenzel, Duygu Tosun, Murat Bilgel, Yang An, Daniel S Marcus, Pamela LaMontagne, Susan R Heckbert, Thomas R Austin, Lenore J Launer, Aristeidis Sotiras, Mark A Espeland, Colin L Masters, Paul Maruff, Jurgen Fripp, Sterling C Johnson, John C Morris, Marilyn S Albert, R Nick Bryan, Kristine Yaffe, Henry Völzke, Luigi Ferrucci, Tammie L S Benzinger, Ali Ezzati, Russell T Shinohara, Yong Fan, Susan M Resnick, Mohamad Habes, David Wolk, Haochang Shou, Konstantina Nikita, Christos Davatzikos
IMPORTANCE: Brain aging elicits complex neuroanatomical changes influenced by multiple age-related pathologies. Understanding the heterogeneity of structural brain changes in aging may provide insights into preclinical stages of neurodegenerative diseases. OBJECTIVE: To derive subgroups with common patterns of variation in participants without diagnosed cognitive impairment (WODCI) in a data-driven manner and relate them to genetics, biomedical measures, and cognitive decline trajectories...
February 14, 2024: JAMA Psychiatry
#36
JOURNAL ARTICLE
Arne Jensen, Niels Rochow, Manfred Voigt, Gerhard Neuhäuser
BACKGROUND: Fetal growth restriction and immaturity are associated with poor neurocognitive development and child psychopathology affecting educational success at school and beyond. However, the differential effects of either obstetrical risk factor on predicted psychomotor development have not yet been deciphered. OBJECTIVE: This study aimed to separately study the impact of growth restriction and that of immaturity on predicted psychomotor development at the preschool age of 4...
February 2024: AJOG global reports
#37
JOURNAL ARTICLE
Yuchi Zhang, Abdullah Md Sheikh, Shatera Tabassum, Kenichi Iwasa, Abu Zaffar Shibly, Xiaojing Zhou, Ruochen Wang, Jubo Bhuiya, Fatema Binte Abdullah, Shozo Yano, Yoshihito Aoki, Atsushi Nagai
Cerebral small vessel diseases (CSVD) are neurological disorders associated with microvessels, manifested pathologically as white matter (WM) changes and cortical microbleeds, with hypertension as a risk factor. Additionally, a high-fat diet (HFD) can affect peripheral vessel health. Our study explored how HFD affects cerebral small vessels in normotensive WKY, hypertensive SHR, and SHR/SP rats. The MRI results revealed that HFD specifically increased WM hyperintensity in SHR/SP rats. Pathologically, it increased WM pallor and vacuolation in SHR and SHR/SP rats...
February 6, 2024: GeroScience
#38
Weijie Chen, Simin Deng, Huali Jiang, Heng Li, Yu Zhao, Yiqiang Yuan
PURPOSE: To explore the topology of the white matter network in individuals with essential hypertension by graph theory. PATIENTS AND METHODS: T1-weighted image and diffusion tensor imaging (DTI) data from 43 patients diagnosed with essential hypertension (EHT) and 33 individuals with normotension (healthy controls, HCs) were incorporated in this cross-sectional study. Furthermore, structural networks were constructed by graph theory to calculate whole brain network characteristics and intracerebral node characteristics...
2024: International Journal of General Medicine
#39
JOURNAL ARTICLE
Mahmud Mossa-Basha, Jalal B Andre, Esther Yuh, David Hunt, Nina Lapiana, Bradley Howlett, Chloe Krakauer, Paul Crane, Jennifer Nelson, Margaret DeZelar, Kelly Meyers, Eric Larson, James Ralston, Christine L Mac Donald
OBJECTIVES: -To compare brain MRI measures between Adult Changes in Thought (ACT) participants who underwent research, clinical, or both MRI scans, and clinical health measures across the groups and non-MRI subjects. METHODS: -Retrospective cohort study leveraging MRI, clinical, demographic, and medication data from ACT. Three neuroradiologists reviewed MRI scans using NIH Neuroimaging Common Data Elements (CDEs). Total brain and white matter hyperintensity (WMH) volumes, clinical characteristics and outcome measures of brain and overall health were compared between groups...
February 1, 2024: British Journal of Radiology
#40
JOURNAL ARTICLE
Heather G Huddleston, Eleni G Jaswa, Kaitlin B Casaletto, John Neuhaus, Catherine Kim, Melissa Wellons, Lenore J Launer, Kristine Yaffe
BACKGROUND AND OBJECTIVES: Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with an adverse cardiometabolic profile early in life. Increasing evidence links cardiovascular risk factors, such as diabetes and hypertension, to accelerated cognitive aging. However, less is known about PCOS and its relationship to brain health, particularly at midlife. Our goal was to investigate possible associations between PCOS and midlife cognitive function and brain MRI findings in an ongoing prospective study...
February 27, 2024: Neurology
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