Bin Li, Wei Wang, Lu Zhao, Yunxia Wu, Xiaoxue Li, Dingyuan Yan, Qiuxia Gao, Yan Yan, Jie Zhang, Yi Feng, Judun Zheng, Bowen Shu, Jiamei Wang, Huanhuan Wang, Lingjie He, Yunlong Zhang, Mingliang Pan, Dong Wang, Ben Zhong Tang, Yuhui Liao
Conventional antibiotics used for treating tuberculosis (TB) suffer from drug resistance and multiple complications. Here we propose a lesion-pathogen dual-targeting strategy for the management of TB by coating Mycobacterium-stimulated macrophage membranes onto polymeric cores encapsulated with an aggregation-induced emission photothermal agent that is excitable with a 1,064 nm laser. The coated nanoparticles carry specific receptors for Mycobacterium tuberculosis, which enables them to target tuberculous granulomas and internal M...
February 21, 2024: Nature Nanotechnology