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https://www.readbyqxmd.com/read/29665644/biodistribution-of-free-and-encapsulated-99m-tc-fluconazole-in-an-infection-model-induced-by-candida-albicans
#1
Danielle Nogueira de Assis, Raquel Silva Araújo, Leonardo Lima Fuscaldi, Simone Odília Antunes Fernandes, Vanessa Carla Furtado Mosqueira, Valbert Nascimento Cardoso
BACKGROUND: Candida spp is an etiologic agent of fungal infections in hospitals and resistance to treatment with antifungals has been extensively reported. Thus, it is very important to develop formulations that increase effectiveness with low toxicity. In this sense, nanocarriers have been investigated, once they modify drug biodistribution profile. Thus, this study aimed to evaluate the biodistribution of free and encapsulated 99m Tc-fluconazole into nanocapsules (NCs) in an experimental immunosuppressed murine model of Candida albicans infection...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29652047/-physical-therapy-of-psoriasis-the-modern-methodological-approaches
#2
I S Evstigneeva, A G Kulikov, O V Yarustovskaya, A S Shakhova, M G Lutoshkina
This article describes the modern approaches to the application of physical factors for the treatment of various forms of psoriasis taking into consideration the severity of clinical manifestations and the phase of the disease, the extent of disturbances of the functional state of different organs. The principles of prescription of physiotherapeutictreatmnt are formulated taking account of the stages and forms of the disease. Special attention is paid to the high therapeutic effectiveness of ultraviolet irradiation of the skin including narrow-band UVВ (311 nm) as well as to photodynamic therapy (PUVA), intravenous laser irradiation of blood, and ozone therapy...
April 9, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29648446/evans-blue-derivative-functionalized-gold-nanorods-for-photothermal-therapy-enhanced-tumor-chemotherapy
#3
Xiangyu Wang, Shi Gao, Zainen Qin, Rui Tian, Guohao Wang, Xianzhong Zhang, Lei Zhu, Xiaoyuan Chen
Chemotherapy is a standard care for cancer management, but the lack of tumor targeting and high dose-induced side effects still limit its utility in patients. Here, we report a chemotherapy combined with photothermal therapy (PTT) for enhanced cancer ablation by functionalization of gold nanorods (GNR) with a novel small molecule named truncated Evans Blue (tEB). Based on the high binding affinity of tEB with albumin, an Abraxane-like nanodrug, human serum albumin/hydroxycamptothecin (HSA/HCPT), was further complexed with GNR-tEB...
April 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29627979/in-vitro-and-in-vivo-photothermal-cancer-therapeutic-effect-of-mushroom-%C3%AE-glucan-modified-gold-nanorods
#4
Xiaojie Li, Jiajing Zhou, Xiaonan Dong, Wai-Yin Cheng, Hongwei Duan, Peter C K Cheung
The photothermal cancer therapeutic effect of the AuNR-Glu nanohybrids produced by coating the native gold nanorods (AuNRs) with a natural mushroom biopolymer from Pleurotus tuber-regium sclerotial β-glucan (Glu) were studied in the second near infrared window (NIR-II). AuNR-Glu showed low cytotoxicity and highly biocompatibility due to the surface coating of Glu when compared with the native AuNRs. AuNR-Glu nanohybrids had a high photothermal transduction efficiency (η) of 43.12%, causing effective in vitro cell ablation (over 90% cell death) in both HT-29 (94...
April 7, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29622397/the-route-and-timing-of-hydrogen-sulfide-therapy-critically-impacts-intestinal-recovery-following-ischemia-and-reperfusion-injury
#5
Amanda R Jensen, Natalie A Drucker, Jan P Te Winkel, Michael J Ferkowicz, Troy A Markel
PURPOSE: Hydrogen sulfide (H2 S) has many beneficial properties and may serve as a novel treatment in patients suffering from intestinal ischemia-reperfusion injury (I/R). The purpose of this study was to examine the method of delivery and timing of administration of H2 S for intestinal therapy during ischemic injury. We hypothesized that 1) route of administration of hydrogen sulfide would impact intestinal recovery following acute mesenteric ischemia and 2) preischemic H2 S conditioning using the optimal mode of administration as determined above would provide superior protection compared to postischemic application...
March 6, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29559260/intravenously-injected-human-multilineage-differentiating-stress-enduring-cells-selectively-engraft-into-mouse-aortic-aneurysms-and-attenuate-dilatation-by-differentiating-into-multiple-cell-types
#6
Katsuhiro Hosoyama, Shohei Wakao, Yoshihiro Kushida, Fumitaka Ogura, Kay Maeda, Osamu Adachi, Shunsuke Kawamoto, Mari Dezawa, Yoshikatsu Saiki
OBJECTIVES: Aortic aneurysms result from the degradation of multiple components represented by endothelial cells, vascular smooth muscle cells, and elastic fibers. Cells that can replenish these components are desirable for cell-based therapy. Intravenously injected multilineage-differentiating stress-enduring (Muse) cells, endogenous nontumorigenic pluripotent-like stem cells, reportedly integrate into the damaged site and repair the tissue through spontaneous differentiation into tissue-compatible cells...
February 21, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29556368/dual-chemodrug-loaded-single-walled-carbon-nanohorns-for-multimodal-imaging-guided-chemo-photothermal-therapy-of-tumors-and-lung-metastases
#7
Jingxing Yang, Huilan Su, Wenshe Sun, Jiali Cai, Shiyuan Liu, Yimin Chai, Chunfu Zhang
Tumor combination therapy using nano formulations with multimodal synergistic therapeutic effects shows great potential for complete ablation of tumors. However, targeting tumor metastases with nano structures is a major obstacle for therapy. Therefore, developing a combination therapy system able to target both primary tumors and their metastases at distant sites with synergistic therapy is desirable for the complete eradication of tumors. To this end, a dual chemodrug-loaded theranostic system based on single walled carbon nanohorns (SWNHs) is developed for targeting both primary breast tumors and their lung metastases...
2018: Theranostics
https://www.readbyqxmd.com/read/29552392/methods-for-detecting-host-genetic-modifiers-of-tumor-vascular-function-using-dynamic-near-infrared-fluorescence-imaging
#8
Jaidip Jagtap, Gayatri Sharma, Abdul K Parchur, Venkateswara Gogineni, Carmen Bergom, Sarah White, Michael J Flister, Amit Joshi
Vascular supply is a critical component of the tumor microenvironment (TME) and is essential for tumor growth and metastasis, yet the endogenous genetic modifiers that impact vascular function in the TME are largely unknown. To identify the host TME modifiers of tumor vascular function, we combined a novel genetic mapping strategy [Consomic Xenograft Model] with near-infrared (NIR) fluorescence imaging and multiparametric analysis of pharmacokinetic modeling. To detect vascular flow, an intensified cooled camera based dynamic NIR imaging system with 785 nm laser diode based excitation was used to image the whole-body fluorescence emission of intravenously injected indocyanine green dye...
February 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29546617/intravenous-injection-of-artificial-red-cells-and-subsequent-dye-laser-irradiation-causes-deep-vessel-impairment-in-an-animal-model-of-port-wine-stain
#9
Naoaki Rikihisa, Mai Tominaga, Shoji Watanabe, Nobuyuki Mitsukawa, Yoshiaki Saito, Hiromi Sakai
Our previous study proposed using artificial blood cells (hemoglobin vesicles, Hb-Vs) as photosensitizers in dye laser treatment for port-wine stains (PWSs). Dye laser photons are absorbed by red blood cells (RBCs) and hemoglobin (Hb) mixture, which potentially produce more heat and photocoagulation and effectively destroy endothelial cells. Hb-Vs combination therapy will improve clinical outcomes of dye laser treatment for PWSs because very small vessels do not contain sufficient RBCs and they are poor absorbers/heaters of lasers...
March 15, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29541691/acute-primary-angle-closure-in-sturge-weber-syndrome
#10
Wei-Wen Su
Purpose: Sturge-Weber syndrome (SWS) is a neurocutaneous disorder characterized by facial cutaneous venous dilatation (port-wine stain), leptomeningeal angioma, and ocular abnormalities. Here we report a case of SWS who experienced acute primary angle-closure in the same side of the nevus flammeus. Observations: A 64-years-old female patient with SWS port wine stain on the left side of her face was referred to our ER for acute primary angle-closure (PAC). The IOP was 64 mmHg in the left eye (12 mmHg in OD) and the visual acuity was 20/100...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29508612/fluorescent-carbon-quantum-dots-with-intrinsic-nucleolus-targeting-capability-for-nucleolus-imaging-and-enhanced-cytosolic-and-nuclear-drug-delivery
#11
Xian-Wu Hua, Yan-Wen Bao, Fu-Gen Wu
Nucleolus tracking and nucleus-targeted photodynamic therapy are attracting increasing attention due to the importance of nucleolus and the sensitivity of nucleus to various therapeutic stimuli. Herein, a new class of multifunctional fluorescent carbon quantum dots (or carbon dots, CDs) synthesized via the one-pot hydrothermal reaction of m-phenylenediamine and L-cysteine, was reported to effectively target nucleolus. The as-prepared CDs possess superior properties such as low-cost and facile synthesis, good water dispersibility, various surface groups for further modifications, prominent photostability, excellent compatibility, and rapid/convenient/wash-free staining procedures...
March 6, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29508232/rare-case-of-osteomyelitis-of-tibial-shaft-caused-by-nocardia-cyriacigeorgica
#12
D Raszka, S Popelka, J Heřt, D Jahoda, I Landor, P Vavřík
Nocardiosis is a rare infection caused by the aerobic actinomycete of the Nocardia genus. In most cases, nocardiosis manifests as a lung infection or a bone lesion. Due to the nonspecific and mild clinical manifestations of nocardiosis, the establishment of definite diagnosis can be difficult. When antibiotic therapy is incorrectly targeted, only the symptoms of the disease are suppressed. The mainstay in the treatment of Nocardia osteomyelitis has so far been the combined surgical debridement with long-term, initially intravenous, antibiotic administration...
March 5, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29506983/liver-zonation-index-of-drug-transporter-and-metabolizing-enzyme-protein-expressions-in-mouse-liver-acinus
#13
Masanori Tachikawa, Yuna Sumiyoshiya, Daisuke Saigusa, Kazunari Sasaki, Michitoshi Watanabe, Yasuo Uchida, Tetsuya Terasaki
The purpose of the present study was to clarify the molecular basis of zonated drug distributions in mouse liver based on the protein expression levels of transporters and metabolizing enzymes in peri-portal vein (PP) and peri-central vein (PC) regions of mouse hepatic lobules. The distributions of sulforhodamine 101 (SR-101), a substrate of organic anion transporting polypeptides (Oatps), and ribavirin, a substrate of equilibrative nucleoside transporter 1 (Ent1), were elucidated in frozen liver sections of mice to which each compound had been intravenously administered...
March 5, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29503965/unusually-very-late-onset-new-growth-of-intraocular-retinoblastoma-a-case-report-and-review-of-literature
#14
Yeshigeta Gelaw, Shoeib Mohamed Shoukry, Ihab Saad Othman
Purpose: To report a patient who presented with a very late-onset new growth of intraocular retinoblastoma, which occurred 11 years after the initial combined treatment. Observations: A 12-year-old monoophthalmic female patient presented with bilateral familial retinoblastoma showing new growth of intraocular tumor after 11 years of complete regression following combined local and systemic treatments. The new tumor growth was treated with diode laser transpupillary thermotherapy, ruthenium-106 plaque radiotherapy and adjuvant intravenous chemotherapy and the tumor regressed...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29496683/downstream-microvascular-thrombosis-in-cortical-venules-is-an-early-response-to-proximal-cerebral-arterial-occlusion
#15
Jean-Philippe Desilles, Varouna Syvannarath, Lucas Di Meglio, Célina Ducroux, William Boisseau, Liliane Louedec, Martine Jandrot-Perrus, Jean-Baptiste Michel, Mikael Mazighi, Benoît Ho-Tin-Noé
BACKGROUND: Previous experimental studies have shown that downstream microvascular thromboinflammation is involved in brain damage from acute ischemic stroke. Using intravital microscopy, we investigated and characterized the sequence of downstream microvascular thromboinflammation in an ischemia/reperfusion acute ischemic stroke model. METHODS AND RESULTS: Rats underwent transient monofilament middle cerebral artery (MCA) occlusion. Cerebral microcirculation in the MCA territory was exposed through a craniotomy and analyzed using real-time intravital imaging coupled with laser Doppler interferometry...
March 1, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29491489/genome-wide-analysis-revealed-that-dznep-reduces-tubulointerstitial-fibrosis-via-down-regulation-of-pro-fibrotic-genes
#16
Imari Mimura, Yosuke Hirakawa, Yasuharu Kanki, Ryo Nakaki, Yutaka Suzuki, Tetsuhiro Tanaka, Hiroyuki Aburatani, Masaomi Nangaku
Tubulointerstitial fibrosis has been recently reported to be caused by the collapse of the epigenetic regulation of kidney diseases. We examined whether pharmacological inhibition of histone modification is effective against renal fibrosis. DZNep (3-deazaneplanocin A) was originally developed as an anti-cancer drug to inhibit the repressive histone mark, H3K27me3. We used a model of chronic tubulointerstitial fibrosis induced by unilateral ischaemia/reperfusion and administered DZNep intravenously to the mice for 8 weeks...
February 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29462817/the-interaction-of-n-acetylcysteine-and-serum-transferrin-promotes-bacterial-biofilm-formation
#17
Supeng Yin, Bei Jiang, Guangtao Huang, Yulong Zhang, Bo You, Yu Chen, Yali Gong, Jing Chen, Zhiqiang Yuan, Yan Zhao, Ming Li, Fuquan Hu, Zichen Yang, Yizhi Peng
BACKGROUND/AIMS: N-acetylcysteine (NAC) is a novel and promising agent with activity against bacterial biofilms. Human serum also inhibits biofilm formation by some bacteria. We tested whether the combination of NAC and human serum offers greater anti-biofilm activity than either agent alone. METHODS: Microtiter plate assays and confocal laser scanning microscopy were used to evaluate bacterial biofilm formation in the presence of NAC and human serum. qPCR was used to examine expression of selected biofilm-associated genes...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29461122/synchronous-delivery-of-oxygen-and-photosensitizer-for-alleviation-of-hypoxia-tumor-microenvironment-and-dramatically-enhanced-photodynamic-therapy
#18
Xiaomeng Guo, Jiaxin Qu, Chunqi Zhu, Wei Li, Lihua Luo, Jie Yang, Xiaoyi Yin, Qingpo Li, Yongzhong Du, Dawei Chen, Yunqing Qiu, Yan Lou, Jian You
Photosensitizer, proper laser irradiation, and oxygen are essential components for effective photodynamic therapy (PDT) in clinical cancer therapy. However, native hypoxic tumoral microenvironment is a major barrier hindering photodynamic reactions in vivo. Thus, we have prepared biocompatible liposomes by loading complexes of oxygen-carrier (hemoglobin, Hb) and photosensitizer (indocyanine green, ICG) for enhanced PDT against hypoxic tumor. Ideal oxygen donor Hb, which is an oxygen-carried protein in red blood cells, makes such liposome which provide stable oxygen supply...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29454329/bilateral-acute-angle-closure-glaucoma-following-tramadol-subcutaneous-administration
#19
Anis Mahmoud, Fatma Abid, Imen Ksiaa, Sourour Zina, Riadh Messaoud, Moncef Khairallah
BACKGROUND: To report a case of bilateral acute angle closure-glaucoma following the use of subcutaneous Tramadol. CASE PRESENTATION: A 42-year-old healthy man with unremarkable past medical and ocular history, was admitted to the Orthopedic Department for surgical treatment of a bilateral open fracture of the femur following a road accident. Three hoursafterTramadolsubcutaneous injection, the patient complained of a bilateral acute painful visual loss with persistent vomiting...
February 17, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29451774/organic-semiconducting-photoacoustic-nanodroplets-for-laser-activatable-ultrasound-imaging-and-combinational-cancer-therapy
#20
Wei Tang, Zhen Yang, Sheng Wang, Zhantong Wang, Jibin Song, Guocan Yu, Wenpei Fan, Yunlu Dai, Jingjing Wang, Lingling Shan, Gang Niu, Quli Fan, Xiaoyuan Chen
Combination of photoacoustic (PA) and ultrasound (US) imaging offers high spatial resolution images with deep tissue penetration, which shows great potential in applications in medical imaging. Development of PA/US dual-contrast agents with high contrast and excellent biocompatibility is of great interest. Herein, an organic semiconducting photoacoustic nanodroplet, PS-PDI-PAnD, is developed by stabilizing low-boiling-point perfluorocarbon (PFC) droplet with a photoabsorber and photoacoustic agent of perylene diimide (PDI) molecules and coencapsulating the droplet with photosensitizers of ZnF16 Pc molecules...
February 21, 2018: ACS Nano
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