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https://www.readbyqxmd.com/read/28814861/the-influence-of-direct-laser-metal-sintering-implants-on-the-early-stages-of-osseointegration-in-diabetic-mini-pigs
#1
Naiwen Tan, Xiangwei Liu, Yanhui Cai, Sijia Zhang, Bo Jian, Yuchao Zhou, Xiaoru Xu, Shuai Ren, Hongbo Wei, Yingliang Song
BACKGROUND: High failure rates of oral implants have been reported in diabetic patients due to the disruption of osseointegration. The aim of this study was to investigate whether direct laser metal sintering (DLMS) could improve osseointegration in diabetic animal models. METHODS: Surface characterizations were carried out on two types of implants. Cell morphology and the osteogenic-related gene expression of MG63 cells were observed under conditions of DLMS and microarc oxidation (MAO)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28810961/resuscitation-of-hypotensive-traumatic-brain-injured-animals-with-spray-dried-plasma-does-not-adversely-alter-physiology-and-improves-blood-brain-barrier-function
#2
Steven McDaniel, Stephanie Golla, Anthony N Moore, Joe DaCorta, Arthur Bode, Shibani Pati, Pramod K Dash, Jing Zhao
INTRODUCTION: According to the Defense and Veterans Brain Injury Center and the Armed Forces Health Surveillance Center, the number of soldiers who have sustained a traumatic brain injury (TBI) has risen dramatically over the past decade. Studies have shown that brain damage can be exacerbated if blood loss occurs (often occurring in polytrauma). As blood supply is critical for brain function and survival, TBI patients must be properly resuscitated to maintain blood volume, blood pressure, and cerebral perfusion...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810046/aspergillus-endophthalmitis-resulting-in-development-of-retinal-aspergilloma
#3
Lee Kiang, Ashkan Pirouz, Scott Grant, Sean D Adrean, Mehrdad Malihi, Phoebe Lin
A 78-year-old immunocompetent man presented with a 3-month history of painless decreased vision and panuveitis with a macular lesion presumed to be due to endogenous endophthalmitis. He had been treated with systemic, intravenous, and intravitreal antibiotics and antifungal agents as well as intravitreal steroids. A culture from a prior vitrectomy had grown a single colony of Aspergillus thought to be a contaminant. The macular lesion enlarged and caused a tractional retinal detachment. The patient underwent surgery including resection of what appeared to be an invasive retinal aspergilloma, from which polymerase chain reaction and histopathology confirmed Aspergillus fumigatus...
August 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28795690/ir-780-loaded-polymeric-micelles-enhance-the-efficacy-of-photothermal-therapy-in-treating-breast-cancer-lymphatic-metastasis-in-mice
#4
Bin He, Hai-Yan Hu, Tao Tan, Hong Wang, Kao-Xiang Sun, Ya-Ping Li, Zhi-Wen Zhang
Cancer metastasis is responsible for over 90% of breast cancer-related deaths, and inhibiting lymph node metastasis is an option to treat metastatic disease. Herein, we report the use of IR-780-loaded polymeric micelles (IPMs) for effective photothermal therapy (PTT) of breast cancer lymphatic metastasis. The IPMs were nanometer-sized micelles with a mean diameter of 25.6 nm and had good stability in simulated physiological solutions. Under 808-nm laser irradiation, IPMs exhibited high heat-generating capability in both in vitro and in vivo experiments...
August 10, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28767389/use-of-confocal-laser-endomicroscopy-with-a-fluorescently-labeled-fatty-acid-to-diagnose-colorectal-neoplasms
#5
Feihong Deng, Yuan Fang, Zhiyong Shen, Wei Gong, Tao Liu, Jing Wen, Wanling Zhang, Xianjun Zhu, Hui Zhong, Tong Wang, Fachao Zhi, Biao Nie
Endoscopic treatment for early colorectal cancer closely correlates with patient prognosis. However, endoscopic differentiation between carcinomas and non-neoplastic lesions remains difficult. Here, we topically stained colorectal neoplasms with a fatty acid analogue (BODIPY-FA) and quantified the fluorescent signals using confocal laser endomicroscopy (CLE) and fluorescence microscopy. We also analyzed protein expression in colorectal cancer tissues. We found that expression of fatty acid synthase was elevated, while the expression of fatty acid transporters was reduced in colorectal cancer...
July 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28756194/red-blood-cell-membrane-camouflaged-melanin-nanoparticles-for-enhanced-photothermal-therapy
#6
Qin Jiang, Zimiao Luo, Yongzhi Men, Peng Yang, Haibao Peng, Ranran Guo, Ye Tian, Zhiqing Pang, Wuli Yang
Photothermal therapy (PTT) has represented a promising noninvasive approach for cancer treatment in recent years. However, there still remain challenges in developing non-toxic and biodegradable biomaterials with high photothermal efficiency in vivo. Herein, we explored natural melanin nanoparticles extracted from living cuttlefish as effective photothermal agents and developed red blood cell (RBC) membrane-camouflaged melanin (Melanin@RBC) nanoparticles as a platform for in vivo antitumor PTT. The as-obtained natural melanin nanoparticles demonstrated strong absorption at NIR region, higher photothermal conversion efficiency (∼40%) than synthesized melanin-like polydopamine nanoparticles (∼29%), as well as favorable biocompatibility and biodegradability...
July 20, 2017: Biomaterials
https://www.readbyqxmd.com/read/28753800/correlation-between-confocal-laser-endomicroscopy-cellvizio-%C3%A2-and-histological-grading-of-upper-tract-urothelial-carcinoma-a-step-forward-for-a-better-selection-of-patients-suitable-for-conservative-management
#7
Alberto Breda, Angelo Territo, Andrea Guttilla, Francesco Sanguedolce, Martina Manfredi, Luigi Quaresima, Jose M Gaya, Ferran Algaba, Joan Palou, Humberto Villavicencio
BACKGROUND: Despite the recent growing interest in the conservative management of upper tract urothelial carcinoma (UTUC), the diagnostic process is still a challenge for the risk of tumor undergrading. Real-time confocal laser endomicroscopy (CLE) provides in vivo microscopic images of tissues using a low-energy laser light source. OBJECTIVE: To describe our initial experience with CLE for the real-time characterization of UTUC. DESIGN, SETTING, AND PARTICIPANTS: Fourteen flexible ureteroscopies (f-URS) were performed at our center with CLE for UTUC...
June 4, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28751460/optogenetic-central-amygdala-stimulation-intensifies-and-narrows-motivation-for-cocaine
#8
Shelley M Warlow, Mike J F Robinson, Kent C Berridge
Addiction is often characterized by intense motivation for a drug, which may be narrowly focused at the expense of other rewards. Here we examined the role of amygdala-related circuitry in the amplification and narrowing of motivation focus for intravenous cocaine. We paired optogenetic channelrhodopsin (ChR2) stimulation in either central nucleus of amygdala (CeA) or basolateral amygdala (BLA) of female rats with one particular nosepoke-porthole option for earning cocaine infusions (0.3 mg/kg, i.v.). A second alternative porthole earned identical cocaine but without ChR2 stimulation...
July 27, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28745365/elemental-bio-imaging-of-pegylated-nayf4-yb-tm-gd-upconversion-nanoparticles-in-mice-by-laser-ablation-inductively-coupled-plasma-mass-spectrometry-to-study-toxic-side-effects-on-the-spleen-liver-and-kidneys
#9
Qing Li, Zheng Wang, Yirui Chen, Guoxia Zhang
Rare-earth upconversion nanoparticles (UCNPs) are considered stable nanoprobes with low toxicity and deep tissue penetration. However, the increasing use of UCNPs has raised concerns about their potential toxicity in living organisms. Very few studies have reported the toxicity of UCNPs; hence, it is not possible to conclude yet that UCNPs are safe. In this study, the distribution of PEGylated NaYF4:Yb/Tm/Gd nanoparticles (PEG-UCNPs) in female Balb/c mice following intravenous administration, and imaging in the spleen, liver and kidney was examined by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)...
August 16, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28743887/tumor-derived-exosomes-induce-the-formation-of-neutrophil-extracellular-traps-implications-for-the-establishment-of-cancer-associated-thrombosis
#10
Ana C Leal, Daniella M Mizurini, Tainá Gomes, Natalia C Rochael, Elvira M Saraiva, Marcos S Dias, Claudio C Werneck, Micheli S Sielski, Cristina P Vicente, Robson Q Monteiro
Cancer patients are at an increased risk of developing thromboembolic complications. Several mechanisms have been proposed to explain cancer-associated thrombosis including the release of tumor-derived extracellular vesicles and the activation of host vascular cells. It was proposed that neutrophil extracellular traps (NETs) contribute to the prothrombotic phenotype in cancer. In this study, we evaluated the possible cooperation between tumor-derived exosomes and NETs in cancer-associated thrombosis. Female BALB/c mice were orthotopically injected with 4T1 breast cancer cells...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729400/vessel-targeted-chemophototherapy-with-cationic-porphyrin-phospholipid-liposomes
#11
Dandan Luo, Jumin Geng, Nasi Li, Kevin A Carter, Shuai Shao, G Ekin Atilla-Gokcumen, Jonathan F Lovell
Cationic liposomes have been used for targeted drug delivery to tumor blood vessels, via mechanisms that are not fully elucidated. Doxorubicin (Dox)-loaded liposomes were prepared that incorporate a cationic lipid; 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), along with a small amount of porphyrin-phospholipid (PoP). Near infrared (NIR) light induced release of entrapped Dox via PoP-mediated DOTAP photo-oxidation. The formulation was optimized to enable extremely rapid NIR light-triggered Dox release (i...
July 20, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28728188/diagnosing-choroidal-neovascularization-in-asymptomatic-individuals-using-optical-coherence-tomography-angiography
#12
Michael M Park, Carl B Rebhun, Emily D Cole, Ricardo N Louzada, Eduardo A Novais, Fareed Rifai, A Yasin Alibhai, Jay S Duker, Nadia K Waheed
Optical coherence tomography angiography (OCTA) is a noninvasive, rapid imaging technique that generates angiographic images without intravenous dye injections. Cross-sectional studies have described the presence of asymptomatic choroidal neovascularization (CNV) in patients with intermediate age-related macular degeneration (AMD). This case report describes the OCT features on longitudinal follow-up of a patient who started with unilateral asymptomatic CNV and eventually developed symptomatic exudative AMD...
July 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28696155/studies-of-the-precipitation-pattern-of-paclitaxel-in-intravenous-infusions-and-rat-plasma-using-laser-nephelometry
#13
Shaza El-Nemr, Basma Y Al-Najjar, Huner K Omer, Abdelbary M A Elhissi, Mohamed A Alhnan
Cremophor EL (CrEL) is commonly used to solubilize paclitaxel (Ptx); a widely established anticancer agent used against many types of cancer. Using laser-based microplate nephelometry, in this work we assessed the precipitation kinetics of Ptx in CrEL-containing formulations upon dilutions with different infusion media or upon introduction into rat plasma. The precipitation profile of Ptx was assessed for a Taxol-like formulation and compared with an preparation with reduced CrEL content. These two formulations were diluted at various ratios in compatible infusion media and with or without rat plasma...
July 11, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28695222/ratiometric-in-vivo-auditioning-of-targeted-silver-nanoparticles
#14
Kadri Toome, Anne-Mari A Willmore, Päärn Paiste, Allan Tobi, Kazuki N Sugahara, Kalle Kirsimäe, Erkki Ruoslahti, Gary B Braun, Tambet Teesalu
Attaching affinity ligands to nanoparticles (NPs) increases selectivity for targeting cells and tissues, and can result in improved sensitivity and reduced off-target toxicity in diagnostic and therapeutic systems. The decision over key features - NP size, shape, coating strategies and targeting ligands for clinical translation is often hampered by a lack of quantitative in vivo NP homing assays. Sensitive, internally controlled assays are needed which allow for quantitative comparisons (auditions) among various formulations of targeted NPs...
July 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28674791/effects-of-the-gaalas-diode-laser-780%C3%A2-nm-on-the-periodontal-tissues-during-orthodontic-tooth-movement-in-diabetes-rats-histomorphological-and-immunohistochemical-analysis
#15
Mônica Fernandes Gomes, Maria da Graças Vilela Goulart, Lilian Chrystiane Giannasi, Cybelle Mori Hiraoka, Gabriela de Fátima Santana Melo, Aretha Graziela Vilela de Sousa, Celestino José Prudente Nóbrega, Renato Amaro Zangaro, Miguel Angel Castillo Salgado
The purposes of the present study are to assess the effects of the GaAlAs diode laser on the periodontal tissues and to investigate its action on the alveolar bone remodeling process during orthodontic tooth movement in normoglycemic and diabetic rats. Sixty adult male Wistar rats were divided into four groups of 15 rats: normoglycemic (N), diabetic (D), laser-normoglycemic (LN), and laser-diabetic (LD) rats. Diabetes mellitus was induced by a single intravenous injection of 40 mg/kg monohydrated alloxan. The orthodontically moved tooth underwent a force magnitude of 20 cN...
July 3, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28670610/in-vivo-characterization-of-abnormalities-in-small-bowel-diseases-using-probe-based-confocal-laser-endomicroscopy
#16
Naoki Ohmiya, Noriyuki Horiguchi, Tomomitsu Tahara, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Tetsuya Tsukamoto, Makoto Kuroda
BACKGROUND AND STUDY AIMS:  Probe-based confocal laser endomicroscopy (pCLE) enables real-time optical biopsy. Little is known about pCLE imaging deep inside the small bowel, therefore the aim of this study was to determine its usefulness. PATIENTS AND METHODS:  Between April 2014 and January 2016, we performed 38 pCLE examinations during double-balloon enteroscopy with intravenous fluorescein in 37 patients with: tumors (n = 10), vascular disorders (n = 6), inflammatory diseases and drug injuries (n = 13), other disorders (n = 4), and normal findings (n = 4)...
July 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28661430/analysis-of-hypericin-mediated-effects-and-implications-for-targeted-photodynamic-therapy
#17
Laura Mühleisen, Magdalena Alev, Harald Unterweger, Daniel Subatzus, Marina Pöttler, Ralf P Friedrich, Christoph Alexiou, Christina Janko
The phototoxic effect of hypericin can be utilized for Photodynamic Therapy (PDT) of cancer. After intravenous application and systemic distribution of the drug in the patient's body, the tumor site is exposed to light. Subsequently, toxic reactive oxygen species (ROS) are generated, inducing tumor cell death. To prevent unwanted activation of the drug in other regions of the body, patients have to avoid light during and after the treatment cycles, consequently impairing quality of life. Here, we characterize toxicity and hypericin-mediated effects on cancer cells in vitro and confirm that its effect clearly depends on concentration and illumination time...
June 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28652897/low-level-laser-therapy-in-russia-history-science-and-practice
#18
REVIEW
Sergey Vladimirovich Moskvin
In Russia (formerly USSR) study of biomodulation action (BMA) mechanisms of low-intensity laser irradiation (LILI) began in 1964, immediately after the development of lasers. During the period from 1965 to 1972 several dozens of scientific conferences were held, hundreds of studies were published. Generally, secondary mechanisms and results of LILI effect on patients with various diseases were studied. This data was immediately implemented into practical medicine in the fields of oncology, surgery, dermatology and dentistry, and since 1974 low level laser therapy (LLLT) is included in the standard of state medical care...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/28650926/hypercapnia-induced-amelioration-of-the-intestinal-microvascular-oxygenation-in-sepsis-is-independent-of-the-endogenous-sympathetic-nervous-system
#19
Jan Schulz, Sabrina Schöneborn, Christian Vollmer, Richard Truse, Anna Herminghaus, Inge Bauer, Christopher Beck, Olaf Picker
INTRODUCTION: Insufficient microvascular oxygenation (μHBO2) of the intestinal mucosa worsens outcome of septic patients. Hypercapnia ameliorates μHBO2, mediated via endogenous vasopressin release. Under physiological conditions, blockade of the endogenous sympathetic nervous system abolishes this protective effect of hypercapnia. The aim of our study was therefore to evaluate the role of the endogenous sympathetic nervous system during hypercapnia on intestinal μHBO2 under septic conditions...
June 23, 2017: Shock
https://www.readbyqxmd.com/read/28650856/a-rare-case-of-pupillary-block-glaucoma-following-centraflow-implantable-collamer-lens-surgery
#20
Isha G Grover, Sirisha Senthil, Somasheila Murthy, Jagadesh C Reddy
A 28-year-old lady with a refractive error of -11.0 D sphere/-1.50 D cylinder at 160 degrees in the right eye underwent an uneventful Implantable Collamer Lens surgery (ICL) with a V4c model, which uses a central Aquaport. This ICL does not require preoperative laser iridotomy or surgical iridectomy, as the centraflow opening is designed to prevent pupillary block. At postoperative day 1, her visual acuity in the right eye was 20/400, with diffuse microcystic corneal edema with fixed, dilated pupil and high intraocular pressure...
August 2017: Journal of Glaucoma
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