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https://www.readbyqxmd.com/read/29243898/invasive-treatment-of-superficial-veins-of-the-lower-extremities
#1
Jukka Saarinen
Modern invasive treatment of superficial venous insufficiency of the lower extremities is largely based on the use of intravenous procedures under ultrasound guidance. The first-line treatment is thermoablation, in which the insufficient superficial vein, typically vena saphena magna or parva, is constricted by using laser or radio frequency energy under ultrasound guidance. The procedure is nearly always successful under local anesthesia and can be performed as an outpatient operation. When necessary, visible collateral varices can be treated with foam sclerotherapy or by surgical excision...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29243035/systemic-lupus-erythematosus-and-ocular-involvement-an-overview
#2
REVIEW
Rosanna Dammacco
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease of undefined etiology and with remarkably heterogeneous clinical features. Virtually any organ system can be affected, including the eye. SLE-related eye involvement can be diagnosed in approximately one-third of the patients and is usually indicative of disease activity. An early diagnosis and the adoption of suitable therapeutic measures are necessary to prevent sight-threatening consequences, especially in patients with juvenile SLE. Periocular lesions, such as eyelid involvement and orbital inflammation, are relatively rare and, in case of orbital masses, may require a biopsy control...
December 14, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29242243/an-infrared-dye-conjugated-virus-like-particle-for-the-treatment-of-primary-uveal-melanoma
#3
Rhonda C Kines, Isabella Varsavsky, Sanghamitra Choudhary, Debaditya Bhattacharya, Sean Spring, Roger J McLaughlin, Shin J Kang, Hans E Grossniklaus, Demitrios G Vavvas, Stephen Monks, John R MacDougall, Elisabet de Los Pinos, John T Schiller
The work outlined herein describes AU-011, a novel recombinant papillomavirus-like particle (VLP) drug conjugate and its initial evaluation as a potential treatment for primary uveal melanoma. The VLP is conjugated with a phthalocyanine photosensitizer, IRDye 700DX, that exerts its cytotoxic effect through photo-activation with a near-infrared laser. We assessed the anti-cancer properties of AU-011 in vitro utilizing a panel of human cancer cell lines and in vivo using murine subcutaneous and rabbit orthotopic xenograft models of uveal melanoma...
December 14, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29234687/delivery-of-cr2-fh-using-aav-vector-therapy-as-treatment-strategy-in-the-mouse-model-of-choroidal-neovascularization
#4
Gloriane Schnabolk, Nathaniel Parsons, Elisabeth Obert, Balasubramaniam Annamalai, Cecile Nasarre, Stephen Tomlinson, Alfred S Lewin, Bärbel Rohrer
Complement activation plays a significant role in age-related macular degeneration (AMD) pathogenesis, and polymorphisms interfering with factor H (fH) function, a complement alternative pathway (AP) inhibitor, are associated with increased AMD risk. We have previously validated an AP inhibitor, a fusion protein consisting of a complement receptor 2 fragment linked to the inhibitory domain of fH (CR2-fH) as an efficacious treatment for choroidal neovascularization (CNV) when delivered intravenously. Here we tested an alternative approach of AAV-mediated delivery (AAV5-VMD2-CR2-fH or AAV5-VMD2-mCherry) using subretinal delivery in C57BL/6J mice...
June 15, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29232130/atom-transfer-radical-polymerization-of-multi-shelled-cationic-corona-for-the-systemic-delivery-of-sirna
#5
Hyesung Kim, Young Ju Son, Wei Mao, Kam W Leong, Hyuk Sang Yoo
We propose an effective siRNA delivery system by preparing poly(DAMA-HEMA)-multilayered gold nanoparticles using multiple surface-initiated atom transfer radical polymerization (SI-ATRP) processes. The polymeric multilayer structure is characterized by transmission electron microscopy (TEM), matrix-associated laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF), UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS) and ζ-potential. The amount of siRNA electrostatically incorporated into the nanoparticle can be tuned by the number of polymeric shells, which in turn influences the cellular uptake and gene silencing effect...
December 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/29221156/the-protective-role-of-sphingosine-1-phosphate-against-the-action-of-the-vascular-disrupting-agent-combretastatin-a-4-3-o-phosphate
#6
Joanna Shepherd, Matthew Fisher, Abigail Welford, Donald M McDonald, Chryso Kanthou, Gillian M Tozer
Solid tumours vary in sensitivity to the vascular disrupting agent combretastatin A-4 3-O-phosphate (CA4P), but underlying factors are poorly understood. The signaling sphingolipid, sphingosine-1-phosphate (S1P), promotes vascular barrier integrity by promoting assembly of VE-cadherin/β-catenin complexes. We tested the hypothesis that tumour pre-treatment with S1P would render tumours less susceptible to CA4P. S1P (1μM) pretreatment attenuated an increase in endothelial cell (HUVEC) monolayer permeability induced by 10μM CA4P...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29215307/effects-of-intravitreous-sodium-hydrosulfide-on-intraocular-pressure-and-retinopathy-in-ocular-hypertensive-rats
#7
M A Özer, Z Erişgin, S Özen, Y Tekelioğlu, S Takır
We investigated the possible neuroprotectant and intraocular pressure (IOP) lowering effects of intravitreous injection of sodium hydrosulfide (NaSH) in a rodent model of experimental glaucoma. Glaucoma currently is treated by controlling IOP using medications and/or surgery. These methods are not entirely adequate for all patients. We divided 24 rats into three groups. For the control group, the right eye was treated with intravitreous saline. For the glaucoma group, ocular hypertension was induced by photocoagulating three episcleral veins and the limbal plexus of the right eye using an argon laser, then saline was injected into the vitreous of these eyes during the third week...
December 7, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29214668/photofrin%C3%A2-photodynamic-therapy-with-intratumor-photosensitizer-injection-provides-similar-tumor-response-while-reducing-systemic-skin-photosensitivity-pilot-murine-study
#8
Timothy M Baran
OBJECTIVES: The goal of this study was to compare tumor response to Photofrin® photodynamic therapy using intravenous and intratumoral injection of photosensitizer. Systemic skin photosensitivity and photosensitizer distribution were also compared between the two delivery methods. METHODS: SCCVII tumors were initiated in the hind legs of female C3H mice and grown to a volume of ∼1,000 mm3 . Photofrin® was delivered intravenously via the tail vein at a concentration of 2 mg/kg or intratumorally at concentrations ranging from 0...
December 7, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29188736/n-octyl-n-arginine-chitosan-micelles-for-gambogic-acid-intravenous-delivery-characterization-cell-uptake-pharmacokinetics-and-biodistribution
#9
Fan Yu, Fuguang Jiang, Xinhui Tang, Bochu Wang
OBJECTIVE: The deeper research of N-Octyl-N-Arginine chitosan (OACS) as intravenous delivery was characterized, cell uptake study, pharmacokinetics and biodistribution of OACS micelles (GA-OACS) were investigated. SIGNIFICANCE: Gambogic acid (GA) can inhibit the growth of various cancer cells. However, the short elimination half-life time and treatment without targeting limits its application. OACS was synthesized as delivery carrier for GA by us, but the deeper characteration of OACS, such as molecular modeling, pharmacokinetics and biodistribution et al...
November 30, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29162667/reperfusion-of-occluded-branch-retinal-arteries-by-transluminal-nd-yag-laser-embolysis-combined-with-intravenous-thrombolysis-of-urokinase
#10
Fang Chai, Shanshuang Du, Xiquan Zhao, Runsheng Wang
Purpose.  To report successful treatment with transluminal Nd:YAG laser embolysis (TYE) combined with urokinase thrombolysis for reperfusion of occluded branch retinal arteries with visible emboli. Methods A total of 34 eyes from 34 patients with acute, severe vision loss secondary to a branch retinal artery occlusion with visible emboli and retinal whitening were examined. Each patient was administered TYE therapy, which focused on the embolus, using an ocular contact lens; a 0.3-0.9 mJ laser pulse was delivered directly and gradually according to the reaction...
November 21, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29161690/catechins-blunt-the-effects-of-oxldl-and-its-primary-metabolite-phosphatidylcholine-hydroperoxide-on-endothelial-dysfunction-through-inhibition-of-oxidative-stress-and-restoration-of-enos-in-rats
#11
Hao-Hsiang Chang, Chen-Yen Chien, Kuo-Hsin Chen, Shih-Chung Huang, Chiang-Ting Chien
BACKGROUND/AIMS: We explored the effects of catechins (decaffeinated green tea extracts containing (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate and (-)-epigallocatechin gallate) on atherosclerosis risk factors, oxidized low-density lipoprotein (oxLDL) and its primary metabolite, phosphatidylcholine hydroperoxide (PCOOH) induced oxidative injury in cultured endothelial cell line and rats. METHODS: We used endothelial cell line and male Wistar rats to determine the effect of catechins on oxLDL or PCOOH induced oxidative injury including apoptosis, H2O2 level, vascular responses and urinary 8-isoprostane and nitrite/nitrate concentration...
November 22, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29157014/construction-and-cellular-uptake-evaluation-of-redox-responsitive-docetaxel-prodrug-self-assembled-nanoparticles
#12
Guolian Ren, Pei Chen, Jiaqi Tang, Rongrong Wang, Shuai Duan, Ruili Wang, Yin Xie, Shuqiu Zhang
Docetaxel (DTX) solution has some serious adverse side effects. A redox-responsitive DTX prodrug synthesized in our laboratory was used to prepare DTX prodrug self-assembled nanoparticles (DSNPs) with the method of nanoprecipitation. This study aimed to optimize the formulation to develop stable preparation for the delivery of DTX. Single-factor test was used to evaluate the effects of the preparation concentration of DTX prodrug, stirring speed, the types of stabilizers and temperature on the prescription process of DSNPs...
November 21, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29153256/intraoperative-force-and-electrocochleography-measurements-in-an-animal-model-of-cochlear-implantation
#13
J Lo, C Bester, A Collins, C Newbold, A Hampson, S Chambers, H Eastwood, S O'Leary
To preserve residual hearing, techniques for monitoring and reducing the effects of trauma during cochlear implant surgery are being developed. This study examines the relationships between intraoperative recordings (electrode insertion force and electrocochleography), trauma, and hearing loss after cochlear implantation. The study also evaluated the efficacy of intravenous steroids for reducing hearing loss after implantation. Thirty-two normal-hearing guinea pigs were randomly implanted with electrode arrays of differing stiffness ('hard' or 'soft')...
November 9, 2017: Hearing Research
https://www.readbyqxmd.com/read/29123633/efficiency-of-a-new-combined-laser-therapy-in-patients-with-trophic-ulcers-of-lower-extremities-and-chronic-venous-insufficiency
#14
Sergey Vladimirovich Moskvin, Aleksandr Vladimirovich Geynitz, Evgeniy Valer'yevich Askhadulin
Introduction: Treating patients with trophic ulcers (TUs) of venous etiology (VE) is a complicated socio-medical and economic problem. One of the ways to increase treatment efficiency can be a complex therapy, including combined laser action. Methods: The objective of this study was a comparative evaluation of the efficiency of traditional treatment methods in patients with chronic venous diseases of C6 class, and combined laser therapy (LT) according to a new method by LASMIK® device. External exposure was conducted on the 1-4 affected area during one session for 2 minutes per zone (pulsed mode, light pulse duration of 100-130 ns, wavelength 635 nm, by a matrix emitter consisting of eight laser diodes with a surface area of 8 cm2, at a distance of up to 7 cm, pulsed power 40 W)...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29118839/acute-angle-closure-glaucoma-a-potential-blind-spot-in-critical-care
#15
Anna Petsas, George Chapman, Richard Stewart
We report a case of a 69-year-old gentleman who developed an acutely painful eye with loss of visual acuity whilst on the critical care unit. He was admitted three days previously with an infective exacerbation of chronic obstructive pulmonary disease requiring invasive mechanical ventilation. In addition, he received intravenous antibiotics, steroids, nebulised bronchodilators and intravenous aminophylline, together with noradrenaline for blood pressure support. On development of visual symptoms, an emergency ophthalmology review diagnosed acute angle closure glaucoma...
August 2017: Journal of the Intensive Care Society
https://www.readbyqxmd.com/read/29107823/photodynamic-therapy-for-an-iris-metastasis-from-pulmonary-adenocarcinoma
#16
Yanyan Chen, Yuedong Hu
Uveal metastasis is the most common intraocular malignancy. Lung cancer is one of the most common malignancies that metastasize to uvea. Iris involvement is rarely reported. Here we report a case of iris metastasis from pulmonary adenocarcinoma that was treated with photodynamic therapy (PDT). A 65-year-old Chinese man was referred to our hospital for iris white neoplasm and blurred vision for 2 weeks in his right eye. His accepted pulmonary lobectomy, radiotherapy and chemotherapy for pulmonary adenocarcinoma 1year ago and liver metastases were found 2 months earlier...
October 28, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29098298/photocoagulation-of-the-retinal-nonperfusion-area-prevents-the-expression-of-the-vascular-endothelial-growth-factor-in-an-animal-model
#17
Makoto Gozawa, Yoshihiro Takamura, Seiji Miyake, Takehiro Matsumura, Masakazu Morioka, Yutaka Yamada, Masaru Inatani
Purpose: The purpose of this study was to evaluate whether photocoagulation of the retinal nonperfusion area suppresses ocular vascular endothelial growth factor (VEGF) expression in a rabbit retinal vein occlusion (RVO) model. Methods: The retinas of pigmented rabbits were made ischemic by a laser on the main branch of retinal veins following intravenous injection of Rose Bengal. The eyes were enucleated before treatment and at 1, 7, and 14 days after laser occlusion...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29082096/in-vivo-cellular-level-real-time-pharmacokinetic-imaging-of-free-form-and-liposomal-indocyanine-green-in-liver
#18
Yoonha Hwang, Hwanjun Yoon, Kibaek Choe, Jinhyo Ahn, Jik Han Jung, Ji-Ho Park, Pilhan Kim
Indocyanine green (ICG) is a near-infrared fluorophore approved for human use which has been widely used for various clinical applications. Despite the well-established clinical usage, our understanding about the microscopic in vivo pharmacokinetics of systemically administered ICG has been relatively limited. In this work, we successfully visualized real-time in vivo pharmacokinetic dynamics of the intravenously injected free-form and liposomal ICG in cellular resolution by utilizing a custom-built video-rate near infrared laser-scanning confocal microscopy system...
October 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29063193/vasodilatory-effect-of-l-arginine-on-isolated-rabbit-and-human-posterior-ciliary-arteries-in-vitro-and-increased-optic-disc-blood-flow-in-vivo
#19
Hideki Chuman, Takako Sugimoto, Nobuhisa Nao-I
PURPOSE: This study aimed to clarify the vasodilatory effect of L-arginine on isolated rabbit and human posterior ciliary arteries (PCAs) and to investigate changes in optic disc blood flow after an infusion of L-arginine in vivo. METHODS: Vascular ring segments were mounted on a double myograph system. After obtaining maximal contraction following administration of high-K solution, L-arginine was administrated. Six volunteers received an intravenous drip infusion of 100 ml of L-arginine or saline...
October 23, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29049716/bone-marrow-derived-cell-recruitment-to-the-neurosensory-retina-and-retinal-pigment-epithelial-cell-layer-following-subthreshold-retinal-phototherapy
#20
Sergio Caballero, David L Kent, Nilanjana Sengupta, Sergio Li Calzi, Lynn Shaw, Eleni Beli, Leni Moldovan, James M Dominguez, Ramana S Moorthy, Maria B Grant
Purpose: We investigated whether subthreshold retinal phototherapy (SRPT) was associated with recruitment of bone marrow (BM)-derived cells to the neurosensory retina (NSR) and RPE layer. Methods: GFP chimeric mice and wild-type (WT) mice were subjected to SRPT using a slit-lamp infrared laser. Duty cycles of 5%, 10%, 15%, and 20% (0.1 seconds, 250 mW, spot size 50 μm) with 30 applications were placed 50 to 100 μm from the optic disc. In adoptive transfer studies, GFP+ cells were given intravenously immediately after WT mice received SRPT...
October 1, 2017: Investigative Ophthalmology & Visual Science
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