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https://www.readbyqxmd.com/read/29149812/architectures-and-mechanical-properties-of-drugs-and-complexes-of-surface-active-compounds-at-air-water-and-oil-water-interfaces
#1
Dipak K Sarker
BACKGROUND: Drugs can represents a multitude of compounds from proteins and peptides, such as growth hormones and insulin and on to simple organic molecules such as flurbiprofen, ibuprofen and lidocaine. Given the chemical nature of these compounds two features are always present. A portion or portions of the molecule that has little affinity for apolar surfaces and media and the opposite a series of part or one large part that has considerable affinity for hydrophilic, polar or charged media and surfaces...
November 17, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29141056/in-vivo-histological-analysis-of-a-fractional-co2-laser-system-intended-for-treatment-of-soft-tissue
#2
Elisabeth Hurliman, Brian Zelickson, Jeffrey Kenkel
<p>BACKGROUND: Fractional ablative lasers have been shown to be safe and effective for improving wrinkles, scars, skin texture, and dyspigmentation. However, the exact effects of this technology in vivo on epidermal and dermal skin constituents have not been delineated. This study evaluated the in vivo histological effects over time of treatment with a fractional ablative CO2 system, using different treatment parameters. MATERIALS AND METHODS: Healthy adult volunteers were enrolled in this multicenter clinical study...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29135894/deferoxamine-preconditioning-of-irradiated-tissue-improves-perfusion-and-fat-graft-retention
#3
John Flacco, Natalie Chung, Charles P Blackshear, Dre Irizarry, Arash Momeni, Gordon K Lee, Dung Nguyen, Geoffrey C Gurtner, Michael T Longaker, Derrick C Wan
BACKGROUND: Radiation therapy is a mainstay in the treatment of many malignancies, but collateral damage to surrounding tissue, with resultant hypovascularity, fibrosis, and atrophy, can be difficult to reconstruct. Fat grafting has been shown to improve the quality of irradiated skin, but volume retention of the graft is significantly decreased. Deferoxamine (DFO) is a FDA-approved iron-chelating medication for acute iron intoxication and chronic iron overload that has also been shown to increase angiogenesis...
November 8, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29133970/laser-and-platelet-rich-plasma-to-treat-medication-related-osteonecrosis-of-the-jaws-mronj-a-case-report
#4
Carlo Fornaini, Luigi Cella, Aldo Oppici, Anna Parlatore, Fabio Clini, Matteo Fontana, Giuseppe Lagori, Elisabetta Merigo
Aims: The appropriate management of Medication-Related OsteoNecrosis of the Jaw (MRONJ) is still a challenge for dentists and oral surgeons and in these last years high-technology instruments have been proposed at the different steps of interventions, also combined with promoters of tissue repair.The aim of this report is to show the advantages of a combined approach (laser and PRP) for the treatment of MRONJ. Methods: It is described the case of a patient positive for MRONJ observed at the Odontostomatology and Maxillo-Facial Surgery Unit of the Hospital of Piacenza where surgical approach was performed by using different devices: Er:YAG laser (2940 nm) to remove and vaporize necrotic hard tissue until bleeding bone; Platelet-Rich Plasma (PRP) to stimulate hard and soft tissue healing; diode laser (808 nm) to biostimulate the surgical site...
September 30, 2017: Laser Therapy
https://www.readbyqxmd.com/read/29119015/pulmonary-metastasectomy-for-sarcoma-essen-experience
#5
Dumitrita Alina Gafencu, Stefan Welter, Danjouma Housmanou Cheufou, Till Ploenes, Georgios Stamatis, Martin Stuschke, Dirk Theegarten, Christian Taube, Sebastian Bauer, Clemens Aigner
Background: Pulmonary metastasectomy is an established treatment modality for patients with soft as well as bone tissue sarcomas. Aim of this study is to describe the Essen experience in the surgical management of patients with pulmonary sarcoma metastases. Methods: This is a retrospective single center analysis of perioperative outcome of patients undergoing pulmonary metastasectomy for sarcoma metastases from 1997-2017 and a summary of published papers on this topic...
October 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29115816/reversible-self-assembly-of-3d-architectures-actuated-by-responsive-polymers
#6
Cheng Zhang, Jheng-Wun Su, Heng Deng, Yunchao Xie, Zheng Yan, Jian Lin
Assembly of three-dimensional (3D) architectures with defined configurations has important applications in broad areas. Among various approaches of constructing 3D structures, stress-driven assembly provides the capabilities of creating 3D architectures in a broad range of functional materials with unique merits. However, 3D architectures built via previous methods are either simple, irreversible or not free-standing. Furthermore, the substrates employed for the assembly remain flat, thus not involved as parts of the final 3D architectures...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29104846/single-molecule-interactions-of-a-monoclonal-anti-dna-antibody-with-dna
#7
Tatiana A Nevzorova, Qingze Zhao, Yakov A Lomakin, Anastasia A Ponomareva, Alexander R Mukhitov, Prashant K Purohit, John W Weisel, Rustem I Litvinov
Interactions of DNA with proteins are essential for key biological processes and have both a fundamental and practical significance. In particular, DNA binding to anti-DNA antibodies is a pathogenic mechanism in autoimmune pathology, such as systemic lupus erythematosus. Here we measured at the single-molecule level binding and forced unbinding of surface-attached DNA and a monoclonal anti-DNA antibody MRL4 from a lupus erythematosus mouse. In optical trap-based force spectroscopy, a microscopic antibodycoated latex bead is trapped by a focused laser beam and repeatedly brought into contact with a DNA-coated surface...
March 2017: BioNanoScience
https://www.readbyqxmd.com/read/29092241/2-5-tw-two-cycle-ir-laser-pulses-via-frequency-domain-optical-parametric-amplification
#8
V Gruson, G Ernotte, P Lassonde, A Laramée, M R Bionta, M Chaker, L Di Mauro, P B Corkum, H Ibrahim, B E Schmidt, F Legaré
Broadband optical parametric amplification in the IR region has reached a new milestone through the use of a non-collinear Frequency domain Optical Parametric Amplification system. We report a laser source delivering 11.6 fs pulses with 30 mJ of energy at a central wavelength of 1.8 μm at 10 Hz repetition rate corresponding to a peak power of 2.5 TW. The peak power scaling is accompanied by a pulse shortening of about 20% upon amplification due to the spectral reshaping with higher gain in the spectral wings...
October 30, 2017: Optics Express
https://www.readbyqxmd.com/read/29092222/streaking-of-43-attosecond-soft-x-ray-pulses-generated-by-a-passively-cep-stable-mid-infrared-driver
#9
Thomas Gaumnitz, Arohi Jain, Yoann Pertot, Martin Huppert, Inga Jordan, Fernando Ardana-Lamas, Hans Jakob Wörner
Attosecond metrology has so far largely remained limited to titanium:sapphire lasers combined with an active stabilization of the carrier-envelope phase (CEP). These sources limit the achievable photon energy to ∼100 eV which is too low to access X-ray absorption edges of most second- and third-row elements which are central to chemistry, biology and material science. Therefore, intense efforts are underway to extend attosecond metrology to the soft-X-ray (SXR) domain using mid-infrared (mid-IR) drivers. Here, we introduce and experimentally demonstrate a method that solves the long-standing problem of the complete temporal characterization of ultra-broadband (≫10 eV) attosecond pulses...
October 30, 2017: Optics Express
https://www.readbyqxmd.com/read/29092141/absolute-high-accuracy-characterization-of-a-variable-line-spacing-grating-for-the-european-xfel-soft-x-ray-monochromator
#10
Maurizio Vannoni, Idoia Freijo-Martin
The European XFEL is a free-electron laser (FEL) with a superconducting linear accelerator and three beamlines (SASE1, SASE2, and SASE3) covering the energy range from 250 eV to 24 keV. The SASE3 beamline is dedicated to the soft x-ray range (0.25-3 keV) and is designed to operate in both monochromatic and non-monochromatic mode. A variable line spacing - plane grating (VLS-PG) monochromator is placed along the beam transport system for the monochromatic mode. The VLS parameters of the grating profile are challenging from a manufacturing and measuring perspective, especially at the desired length of 530 mm...
October 30, 2017: Optics Express
https://www.readbyqxmd.com/read/29089201/quantitative-analysis-of-facial-soft-tissue-perfusion-during-hypotensive-anesthesia-using-laser-assisted-indocyanine-green-fluorescence-angiography
#11
J McCabe, C Guevara, J Renfroe, T Fattahi, S Salman, B Steinberg
The aim of this study was to quantitatively evaluate the efficacy of induced hypotensive anesthesia in decreasing facial soft tissue perfusion during orthognathic surgery using laser-assisted indocyanine green fluorescence angiography. This retrospective study involved the evaluation of 16 patients who underwent orthognathic surgery. Data collection included facial tissue perfusion of the bilateral cheeks and chin at normotension and with pharmacologically induced hypotensive anesthesia. There were statistically significant differences in the facial tissue perfusion at normal and depressed levels of blood pressure (P<0...
October 28, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29083144/enhanced-cell-chip-coupling-by-rapid-femtosecond-laser-patterning-of-soft-pedot-pss-biointerfaces
#12
Francesca Santoro, Yoeri van de Burgt, Scott Tom Keene, Bianxiao Cui, Alberto Salleo
Interfacing soft materials with biological systems holds considerable promise for both biosensors and recording live cells. However, the interface between cells and organic substrates is not well studied, despite its crucial role in the effectiveness of the device. Furthermore, well-known cell adhesion enhancers, such as microgrooves, have not been implemented on these surfaces. Here, we present a nanoscale characterization of the cell-substrate interface for 3D laser-patterned organic electrodes by combining electrochemical impedance spectroscopy (EIS) and scanning electron microscopy/focused ion beam (SEM/FIB)...
November 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29076457/investigating-the-generalisation-of-an-atlas-based-synthetic-ct-algorithm-to-another-centre-and-mr-scanner-for-prostate-mr-only-radiotherapy
#13
Jonathan Wyatt, Jason A Dowling, Charles G Kelly, Jill McKenna, Emily Johnstone, Richard Speight, Ann Henry, Peter B Greer, Hazel Mhairi McCallum
There is increasing interest in MR-only radiotherapy planning since it provides superb soft-tissue contrast without the registration uncertainties inherent in a CT-MR registration. However MR images cannot readily provide the electron density information necessary for radiotherapy dose calculation. An algorithm which generates synthetic CT's for dose calculations from MR images of the prostate using an atlas of 3 T MR images has been previously reported by two of the authors. This paper aimed to evaluate this algorithm using MR data acquired at a different field strength and a different centre to the algorithm atlas...
October 27, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29075023/no-clinical-quantifiable-benefits-between-non-surgical-and-surgical-endodontic-treatment
#14
Debra M Ferrailo, Analia Veitz-Keenan
Data sourcesThe authors searched the following electronic databases: the Cochrane Oral Health Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline Ovid and Embase Ovid. The US National Registry of Clinical Trials (ClinicalTrials.gov) and the World Health Organisation (WHO) International Clinical Trials Registry Platform were searched for ongoing trials. There were no restrictions regarding language and publication date. The authors hand-searched the reference lists of the studies retrieved and key journals in the field of endodontics...
October 27, 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/29072662/-the-potential-of-physiotherapy-after-rhinoplasty
#15
T A Aleksanyan
This article presents the results of the evaluation of the effectiveness of physiotherapy during the postoperative period following rhinoplastic surgery based on the analysis of the dynamics of the clinical symptoms in 374 patients divided into two groups. The main group was comprised of 286 (86.5%) patients who had undergone the comprehensive postoperative rehabilitation with the use of the chosen physiotherapeutic procedures while the group of comparison consisted of 88 (23.5%) patients treated othrerwise...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29065540/activation-of-alkaline-irrigation-fluids-in-endodontics
#16
REVIEW
Laurence J Walsh, Roy George
In conventional endodontic treatment, alkaline solutions of sodium hypochlorite (NaOCl) and ethylenediaminetetraacetic acid (EDTA) are used in combination to disinfect the root canal system and to eliminate debris and smear layers. An important concept that has emerged over recent years is the use of active physical methods for agitating these fluids to improve their penetration within areas that are not reached by endodontic instruments and to accelerate the chemical actions of these alkaline fluids against planktonic microorganisms, biofilms, soft tissue remnants and smear layers...
October 23, 2017: Materials
https://www.readbyqxmd.com/read/29064612/wavelength-gated-dynamic-covalent-chemistry
#17
Hendrik Frisch, David Marschner, Anja Goldmann, Christopher Barner-Kowollik
Precise control of chemical reactions constitutes the foundation of synthesis. Classically, judicious functional group choice as well as external factors such as temperature and catalysts are used to exert control, yet the recent renaissance of light as a medium to direct chemical synthesis points to the advent of a new era in enabling chemical selectivity. Light-guided reactions not only offer precise temporal and spatial control, yet critically allow to selectively address highly specific reaction channels gated by wavelength and intensity, resulting in a unique level of reaction control via covalent bonds that can be made and unmade by finely regulated photonic fields...
October 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29059048/short-wavelength-free-electron-laser-sources-and-science-a-review
#18
E A Seddon, J A Clarke, D J Dunning, C Masciovecchio, C J Milne, F Parmigiani, D Rugg, J C H Spence, N R Thompson, K Ueda, S M Vinko, J S Wark, W Wurth
This review is focused on free-electron lasers (FELs) in the hard to soft x-ray regime. The aim is to provide newcomers to the area with insights into: the basic physics of FELs, the qualities of the radiation they produce, the challenges of transmitting that radiation to end users and the diversity of current scientific applications. Initial consideration is given to FEL theory in order to provide the foundation for discussion of FEL output properties and the technical challenges of short-wavelength FELs. This is followed by an overview of existing x-ray FEL facilities, future facilities and FEL frontiers...
November 2017: Reports on Progress in Physics
https://www.readbyqxmd.com/read/29054109/influence-of-backside-loading-on-the-floating-mass-transducer-an-in-vitro-experimental-study
#19
Antoniu-Oreste Gostian, Martin Sylvester Otte, David Pazen, Magdalene Ortmann, David Schwarz, Karl Bernd Hüttenbrink, Dirk Beutner
HYPOTHESIS: The vibration of the floating mass transducer (FMT) of a single active middle-ear implant (AMEI) is distinctly influenced by the properties of the material coupled to its back side. BACKGROUND: In round window vibroplasty, the FMT needs to be padded against the surrounding bone opposite from the round window membrane. This represents one factor influencing its performance as a round window driver. Therefore, we examined the effects of different materials linked to the back side of an FMT on its vibration range...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29053657/histological-differences-in-the-adherence-of-connective-tissue-to-laser-treated-abutments-and-standard-abutments-for-dental-implants-an-experimental-pilot-study-in-humans
#20
M Blázquez-Hinarejos, R Ayuso-Montero, J-M Álvarez-López, M-C Manzanares-Céspedes, J López-López
BACKGROUND: The goal of the current study is to assess the difference in connective tissue adherence to laser microtextured versus machined titanium abutments. MATERIAL AND METHODS: Six patients were selected and each of them received 2 implants, one combined with a laser treated abutment and one with a machined abutment. After three months, the abutments were retrieved together with their surrounding gingival tissue for histological analysis. Qualitative and quantitative evaluation of microscopical images was performed to assess the presence or absence of adherence between the soft tissues and the abutment, and the percentage of soft tissue adhered to the two different surfaces...
November 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
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