Xiaotong Wang, Xiaoyu Chen, Zong-Jie Wang, Mengwei Zhuang, Lin Zhong, Chengzhang Fu, Ronald Garcia, Rolf Müller, Youming Zhang, Jie Yan, Dalei Wu, Liujie Huo
The genomes of myxobacteria harbor a variety of biosynthetic gene clusters encoding numerous secondary metabolites, including ribosomally synthesized and post-translationally modified peptides (RiPPs) with diverse chemical structures and biological activities. However, the biosynthetic potential of RiPPs from myxobacteria remains barely explored. Herein, we report a novel myxobacteria lanthipeptide myxococin identified from Myxococcus fulvus . Myxococins represent the first example of lanthipeptides, of which the characteristic multiple thioether rings are installed by employing a Class II lanthipeptide synthetase MfuM and a Class I lanthipeptide cyclase MfuC in a cascaded way...
July 19, 2023: Journal of the American Chemical Society