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JOURNAL ARTICLE
Marco Stellato, Sebastiano Buti, Marco Maruzzo, Maria Bassanelli, Melissa Bersanelli, Marilena Di Napoli, Michele Dionese, Martina Fanelli, Roberto Filippi, Giuseppe Fotia, Luca Galli, Francesco Grillone, Michele Maffezzoli, Brigida Anna Maiorano, Cecilia Nasso, Sara Elena Rebuzzi, Luca Lalli, Giandomenico Roviello, Mariella Sorarù, Bruno Vincenzi, Giuseppe Procopio, Elena Verzoni
BACKGROUND: Peritoneal metastases (PM) have been reported in approximately 1% of patients with metastatic Renal Cell Carcinoma (mRCC). Outcome data are limited due to the rarity of this metastatic site. Therefore, the aim of our study is to describe renal cell carcinoma (RCC) patients with PM treated as per clinical practice. MATERIALS AND METHODS: Baseline characteristics and outcome data of patients with PM from RCC were retrospectively collected from 18 Italian oncological referral centers adhering to the Meet-Uro group, from January 2016 to January 2023...
March 19, 2024: Clinical Genitourinary Cancer
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JOURNAL ARTICLE
M Chianelli, L Busetto, R Vettor, B Annibale, A Paoletta, E Papini, A Albanese, M Carabotti, D Casarotto, G De Pergola, O E Disoteo, I Grandone, G Medea, E Nisoli, M Raffaelli, S Schiff, F Vignati, M Cinquini, M Gonzalez-Lorenzo, V A Fittipaldo, S Minozzi, M Monteforte, A C Tralongo, R Novizio, A Persichetti, I Samperi, A Scoppola, G Borretta, M Carruba, M G Carbonelli, M De Luca, S Frontoni, S G Corradini, F Muratori, R Attanasio
AIM: This guideline (GL) is aimed at providing a clinical practice reference for the management of adult patients with overweight or obesity associated with metabolic complications who are resistant to lifestyle modification. METHODS: Surgeons, endocrinologists, gastroenterologists, psychologists, pharmacologists, a general practitioner, a nutritionist, a nurse and a patients' representative acted as multi-disciplinary panel. This GL has been developed following the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach...
April 17, 2024: Journal of Endocrinological Investigation
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JOURNAL ARTICLE
Aline Maria Brito Lucas, Plinio Bezerra Palacio, Pedro Lourenzo Oliveira Cunha, Heberty Tarso Facundo
Calorie restriction is a nutritional intervention that reproducibly protects against the maladaptive consequences of cardiovascular diseases. Pathological cardiac hypertrophy leads to cellular growth, dysfunction (with mitochondrial dysregulation), and oxidative stress. The mechanisms behind the cardiovascular protective effects of calorie restriction are still under investigation. In this study, we show that this dietetic intervention prevents cardiac protein elevation, avoids fetal gene reprogramming (atrial natriuretic peptide), and blocks the increase in heart weight per tibia length index (HW/TL) seen in isoproterenol-induced cardiac hypertrophy...
April 17, 2024: Free Radical Research
#24
JOURNAL ARTICLE
Monica Gandhi, Lucas Hill, Janet Grochowski, Alexander Nelson, Catherine A Koss, Francis Mayorga-Munoz, Jon Oskarsson, Mary Shiels, Ann Avery, Laura Bamford, Jillian Baron, William R Short, Corrilynn O Hileman
BACKGROUND: Injectable cabotegravir (CAB)/rilpivirine (RPV) is the only combination long-acting (LA) antiretroviral regimen approved for HIV. RPV may not be effective among individuals with non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance, which has >10% prevalence in many countries. Lenacapavir (LEN) is an LA capsid inhibitor given every 6 months, but has not been studied in combination with other LA agents. METHODS: We assembled a case series from 4 US academic medical centers where patients with adherence challenges were prescribed LEN subcutaneously every 26 weeks/CAB (+/- RPV) intramuscularly every 4 or 8 weeks...
April 2024: Open Forum Infectious Diseases
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JOURNAL ARTICLE
Sherman Lin, Christopher Tran, Ela Bandari, Tommaso Romagnoli, Yueyang Li, Michael Chu, Abinaya S Amirthakatesan, Adam Dallmann, Andrii Kostiukov, Angel Panizo, Anjelica Hodgson, Anna R Laury, Antonio Polonia, Ashley E Stueck, Aswathy A Menon, Aurélien Morini, Birsen Özamrak, Caroline Cooper, Celestine Marie G Trinidad, Christian Eisenlöffel, Dauda E Suleiman, David Suster, David A Dorward, Eman A Aljufairi, Fiona Maclean, Gulen Gul, Irene Sansano, Irma E Erana-Rojas, Isidro Machado, Ivana Kholova, Jayanthi Karunanithi, Jean-Baptiste Gibier, Jefree J Schulte, Joshua J X Li, Jyoti R Kini, Katrina Collins, Laurence A Galea, Louis Muller, Luca Cima, Luiz M Nova-Camacho, Marcus Dabner, Matthew J Muscara, Matthew G Hanna, Mehdi Agoumi, Nicholas J P Wiebe, Nicola K Oswald, Nusrat Zahra, Olaleke O Folaranmi, Oleksandr Kravtsov, Orhan Semerci, Namrata N Patil, Preethi Muthusamy Sundar, Prem Charles, Priyadarshini Kumaraswamy Rajeswaran, Qi Zhang, Rachael van der Griend, Raghavendra Pillappa, Raul Perret, Raul S Gonzalez, Robyn C Reed, Sachin Patil, Xiaoyin Sara Jiang, Sumaira Qayoom, Susan Prendeville, Swikrity U Baskota, Thanh-Truc Tran, Thar-Htet San, Tiia-Maria Kukkonen, Timothy J Kendall, Toros Taskin, Tristan Rutland, Varsha Manucha, Vincent Cockenpot, Yale Rosen, Yessica P Rodriguez-Velandia, Zehra Ordulu, Matthew J Cecchini
Introduction. The identification of mitotic figures is essential for the diagnosis, grading, and classification of various different tumors. Despite its importance, there is a paucity of literature reporting the consistency in interpreting mitotic figures among pathologists. This study leverages publicly accessible datasets and social media to recruit an international group of pathologists to score an image database of more than 1000 mitotic figures collectively. Materials and Methods. Pathologists were instructed to randomly select a digital slide from The Cancer Genome Atlas (TCGA) datasets and annotate 10-20 mitotic figures within a 2 mm2 area...
April 16, 2024: International Journal of Surgical Pathology
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JOURNAL ARTICLE
Carolin Siech, Andrea Baudo, Mario de Angelis, Letizia Maria Ippolita Jannello, Francesco Di Bello, Jordan A Goyal, Zhe Tian, Fred Saad, Shahrokh F Shariat, Nicola Longo, Luca Carmignani, Ottavio de Cobelli, Alberto Briganti, Séverine Banek, Philipp Mandel, Luis A Kluth, Felix K H Chun, Pierre I Karakiewicz
BACKGROUND: In metastatic urethral cancer, temporal trends, and patterns of inpatient palliative care (IPC) use are unknown. METHODS: Relying on the National Inpatient Sample (2006-2019), metastatic urethral cancer patients were stratified according to IPC use. Estimated annual percentage changes (EAPC) analyses and multivariable logistic regression models (LRM) for the prediction of IPC use were fitted. RESULTS: Of 1,106 metastatic urethral cancer patients, 199 (18%) received IPC...
April 15, 2024: Urologic Oncology
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JOURNAL ARTICLE
Roberta Massobrio, Lorenzo Novara, Matteo Mancarella, Luca Pace, Margherita Giorgi, Maria Pascotto, Beatrice Campigotto, Luca Fuso, Luca Giuseppe Sgro, Valentina Elisabetta Bounous, Annamaria Ferrero
OBJECTIVES: Nodal staging contributes to risk group definition and the indication to adjuvant treatment in endometrial cancer (EC) patients. However, the role of nodal assessment evolved and requires redefinition. Primary outcome of the study was to assess the impact of surgical nodal staging in defining HR EC. Secondary outcome was to evaluate the contribution of nodal assessment to the decision for adjuvant treatment in both HR and HIR patients submitted to surgery. METHODS: Clinical stage I-II EC patients with postoperative diagnosis of HR and HIR disease were included...
April 14, 2024: Journal of Gynecology Obstetrics and Human Reproduction
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JOURNAL ARTICLE
Joline Ingels, Laurenz De Cock, Dieter Stevens, Rupert L Mayer, Fabien Théry, Guillem Sanchez Sanchez, David Vermijlen, Karin Weening, Saskia De Smet, Nele Lootens, Marieke Brusseel, Tasja Verstraete, Jolien Buyle, Eva Van Houtte, Pam Devreker, Kelly Heyns, Stijn De Munter, Sandra Van Lint, Glenn Goetgeluk, Sarah Bonte, Lore Billiet, Melissa Pille, Hanne Jansen, Eva Pascal, Lucas Deseins, Lies Vantomme, Maarten Verdonckt, Ria Roelandt, Thomas Eekhout, Niels Vandamme, Georges Leclercq, Tom Taghon, Tessa Kerre, Floris Vanommeslaeghe, Annemieke Dhondt, Liesbeth Ferdinande, Jo Van Dorpe, Liesbeth Desender, Frederic De Ryck, Frank Vermassen, Veerle Surmont, Francis Impens, Björn Menten, Karim Vermaelen, Bart Vandekerckhove
Non-small cell lung cancer (NSCLC) is known for high relapse rates despite resection in early stages. Here, we present the results of a phase I clinical trial in which a dendritic cell (DC) vaccine targeting patient-individual neoantigens is evaluated in patients with resected NSCLC. Vaccine manufacturing is feasible in six of 10 enrolled patients. Toxicity is limited to grade 1-2 adverse events. Systemic T cell responses are observed in five out of six vaccinated patients, with T cell responses remaining detectable up to 19 months post vaccination...
April 9, 2024: Cell reports medicine
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JOURNAL ARTICLE
Yuanjia Zhu, Shin Yajima, Matthew H Park, Akshay Venkatesh, Charles J Stark, Nicholas A Tran, Sabrina K Walsh, Sidarth Ethiraj, Robert J Wilkerson, Luca E Lin, Seung Hyun Lee, Kate Y Gates, Justin D Arthur, Sam W Baker, Danielle M Mullis, Catherine A Wu, Shun Harima, Bipul Pokhrel, Dominique Resuello, Hunter Bergamasco, Matthew A Wu, Basil M Baccouche, Pearly K Pandya, Stefan Elde, Hanjay Wang, Y Joseph Woo
BACKGROUND: Various mitral repair techniques have been described. Though these repair techniques can be highly effective when performed correctly in suitable patients, limited quantitative biomechanical data are available. Validation and thorough biomechanical evaluation of these repair techniques from translational large animal in vivo studies in a standardized, translatable fashion are lacking. We sought to evaluate and validate biomechanical differences among different mitral repair techniques and further optimize repair operations using a large animal mitral valve prolapse model...
April 2024: Circulation. Cardiovascular Interventions
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JOURNAL ARTICLE
Marco Catarci, Stefano Guadagni, Francesco Masedu, Giacomo Ruffo, Massimo Giuseppe Viola, Felice Borghi, Gianluca Garulli, Felice Pirozzi, Paolo Delrio, Raffaele De Luca, Gianandrea Baldazzi, Marco Scatizzi
BACKGROUND: Current evidence concerning bowel preparation before elective colorectal surgery is still controversial. This study aimed to compare the incidence of anastomotic leakage (AL), surgical site infections (SSIs), and overall morbidity (any adverse event, OM) after elective colorectal surgery using four different types of bowel preparation. METHODS: A prospective database gathered among 78 Italian surgical centers in two prospective studies, including 6241 patients who underwent elective colorectal resection with anastomosis for malignant or benign disease, was re-analyzed through a multi-treatment machine-learning model considering no bowel preparation (NBP; No...
April 16, 2024: International Journal of Colorectal Disease
#31
JOURNAL ARTICLE
Carolina Gil-Garcia, Lucas Tadeu Fuess, André do Vale Borges, Márcia Helena Rissato Zamariolli Damianovic
The establishment of sulfate (SO4 2- ) reduction during methanogenesis may considerably hinder the efficient energetic exploitation of methane, once removing sulfide from biogas is obligate and can be costly. In addition, sulfide generation can negatively impact the performance of methanogens by triggering substrate competition and sulfide inhibition. This study investigated the impacts of removing SO4 2- during fermentation on the performance of a second-stage methanogenic continuous reactor (R2), comparing the results with those obtained in a single-stage system (R1) fed with SO4 2- -rich wastewater (SO4 2- of up to 400 mg L-1 , COD/SO4 2- of 3...
April 16, 2024: Environmental Science and Pollution Research International
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JOURNAL ARTICLE
Lucas J Osborn, John Fissel, Samantha Gomez, Javier Mestas, Jessica Flores-Vazquez, Jaehyeon Lee, Hesamedin Hakimjavadi, Cristina Costales, Jennifer Dien Bard
UNLABELLED: The timely identification of microbial pathogens is essential to guide targeted antimicrobial therapy and ultimately, successful treatment of an infection. However, the yield of standard microbiology testing (SMT) is directly related to the duration of antecedent antimicrobial therapy as SMT culture methods are dependent on the recovery of viable organisms, the fastidious nature of certain pathogens, and other pre-analytic factors. In the last decade, metagenomic next-generation sequencing (mNGS) has been successfully utilized as a diagnostic tool for various applications within the clinical laboratory...
April 16, 2024: Journal of Clinical Microbiology
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JOURNAL ARTICLE
Jesper R Moes, Jara F Vliem, Pedro M M C de Melo, Thomas C Wigmans, Andrés R Botello-Méndez, Rafael G Mendes, Ella F van Brenk, Ingmar Swart, Lucas Maisel Licerán, Henk T C Stoof, Christophe Delerue, Zeila Zanolli, Daniel Vanmaekelbergh
The remarkable development of colloidal nanocrystals with controlled dimensions and surface chemistry has resulted in vast optoelectronic applications. But can they also form a platform for quantum materials, in which electronic coherence is key? Here, we use colloidal, two-dimensional Bi2 Se3 crystals, with precise and uniform thickness and finite lateral dimensions in the 100 nm range, to study the evolution of a topological insulator from three to two dimensions. For a thickness of 4-6 quintuple layers, scanning tunneling spectroscopy shows an 8 nm wide, nonscattering state encircling the platelet...
April 16, 2024: Nano Letters
#34
JOURNAL ARTICLE
Rosetta Blackman, Marjorie Couton, François Keck, Dominik Kirschner, Luca Carraro, Eva Cereghetti, Kilian Perrelet, Raphael Bossart, Jeanine Brantschen, Yan Zhang, Florian Altermatt
Molecular tools are an indispensable part of ecology and biodiversity sciences and implemented across all biomes. About a decade ago, the use and implementation of environmental DNA (eDNA) to detect biodiversity signals extracted from environmental samples opened new avenues of research. Initial eDNA research focused on understanding population dynamics of target species. Its scope thereafter broadened, uncovering previously unrecorded biodiversity via metabarcoding in both well-studied and understudied ecosystems across all taxonomic groups...
April 16, 2024: Molecular Ecology
#35
JOURNAL ARTICLE
Marco Bazi, Edoardo Bracciotti, Lorenzo Fioravanti, Fabio Marchetti, Marzio Rancan, Lidia Armelao, Simona Samaritani, Luca Labella
Rare-earth tris-diketonato [RE(dike)3 pyterpy] metalloligands can be prepared reacting at room temperature [RE(dike)3 dme] (dme = 1,2-dimethoxyethane; dike = tta with Htta = 2-thenoyltrifluoroacetone and RE = La, 1 ; Y, 2 ; Eu, 3 ; Dy, 4 ; or dike = hfac with Hhfac hexafluoroacetylacetone, and RE = Eu, 5 ; Tb, 6 ; Yb 7 ) with 4'-(4‴-pyridil)-2,2':6',2″-terpyridine (pyterpy). The molecular structures of 1 , 5 , 6 , and 7 have been studied through single-crystal X-ray diffraction showing mononuclear neutral complexes with the rare-earth ion in coordination number nine and with a muffin-like coordination geometry...
April 16, 2024: Inorganic Chemistry
#36
JOURNAL ARTICLE
Roberto Manca, Anna Dattolo, Francesco Valenzano, Marina Castriota, Alessandro Martella, Giovanna Galdo, Giuseppe Argenziano, Damiano Abeni, Luca Fania
Dermoscopy is widely used for the diagnosis of skin cancer and it increases the accuracy of basal cell carcinoma (BCC) detection. BCC dermoscopic criteria have been updated and divided into vascular, pigment-related, and non-vascular/non-pigment-related. Our multicenter retrospective study tested a new dermoscopic pigment-related characteristic to detect pigmented BCC (pBCC) [brown homogeneous blotches (BHB)]. Cases of pBCC were collected from the databases of IDI-IRCCS of Rome and from three Italian private dermatology centers...
March 12, 2024: Dermatology Reports
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JOURNAL ARTICLE
Houda Ilahi, Elisa Zampieri, Cristiana Sbrana, Francesca Brescia, Luca Giovannini, Roghayyeh Mahmoudi, Gholamreza Gohari, Mustapha Missbah El Idrissi, Mohamed Najib Alfeddy, Martino Schillaci, Lahcen Ouahmane, Alice Calvo, Fabiano Sillo, Vasileios Fotopoulos, Raffaella Balestrini, Bacem Mnasri
UNLABELLED: Currently, salinization is impacting more than 50% of arable land, posing a significant challenge to agriculture globally. Salt causes osmotic and ionic stress, determining cell dehydration, ion homeostasis, and metabolic process alteration, thus negatively influencing plant development. A promising sustainable approach to improve plant tolerance to salinity is the use of plant growth-promoting bacteria (PGPB). This work aimed to characterize two bacterial strains, that have been isolated from pea root nodules, initially called PG1 and PG2, and assess their impact on growth, physiological, biochemical, and molecular parameters in three pea genotypes (Merveille de Kelvedon, Lincoln, Meraviglia d'Italia) under salinity...
February 2024: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
#38
REVIEW
Thaynara Nascimento de Oliveira, Victor Zanetti Drumond, José Alcides Almeida de Arruda, Sharat Chandra Pani, Fabiana Vargas-Ferreira, Ricardo Rabelo Eustachio, Ricardo Alves Mesquita, Lucas Guimarães Abreu
OBJECTIVE: This systematic review and meta-analysis aimed to compare the occurrence of dental caries and developmental defects of enamel (DDE) in individuals with and without cerebral palsy (CP). MATERIALS AND METHODS: We conducted searches across five databases and the grey literature. Data were organized using EndNote 20. Reporting followed the MOOSE checklist. A random-effects model meta-analyses were conducted using RStudio, presenting results as mean difference (MD), odds ratio (OR), and 95% confidence interval (CI)...
April 16, 2024: Oral Diseases
#39
JOURNAL ARTICLE
Hossein Roshan, Dongxu Zhu, Davide Piccinotti, Jinfei Dai, Manuela De Franco, Matteo Barelli, Mirko Prato, Luca De Trizio, Liberato Manna, Francesco Di Stasio
Heavy-metal-free III-V colloidal quantum dots (QDs) exhibit promising attributes for application in optoelectronics. Among them, InAs QDs are demonstrating excellent optical performance with respect to absorption and emission in the near-infrared spectral domain. Recently, InAs QDs attained a substantial improvement in photoluminescence quantum yield, achieving 70% at a wavelength of 900 nm through the strategic overgrowth of a thick ZnSe shell atop the InAs core. In the present study, light-emitting diodes (LEDs) based on this type of InAs/ZnSe QDs are fabricated, reaching an external quantum efficiency (EQE) of 13...
April 15, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
#40
JOURNAL ARTICLE
Luca Gentile, Anna Mazzeo, Chiara Briani, Silvia Casagrande, Marcella De Luca, Gian Maria Fabrizi, Christian Gagliardi, Chiara Gemelli, Francesca Forcina, Marina Grandis, Valeria Guglielmino, Giacomo Iabichella, Luca Leonardi, Alessandro Lozza, Fiore Manganelli, Roberta Mussinelli, Filomena My, Giuseppe Occhipinti, Silvia Fenu, Massimo Russo, Angela Romano, Alessandro Salvalaggio, Matteo Tagliapietra, Stefano Tozza, Giovanni Palladini, Laura Obici, Marco Luigetti
BACKGROUND: Hereditary transthyretin (ATTRv, v for variant) amyloidosis with polyneuropathy is a rare disease caused by mutations in the transthyretin gene. In ATTRv amyloidosis, multisystem extracellular deposits of amyloid cause tissue and organ dysfunction. Patisiran is a small interfering RNA molecule drug that reduces circulating levels of mutant and wild-type TTR proteins. Prior to its regulatory approval, patisiran was available in Italy through a compassionate use programme (CUP)...
April 16, 2024: Neurological Sciences
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