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https://www.readbyqxmd.com/read/27913949/epigenetic-cpg-methylation-of-the-promoter-and-reactivation-of-the-expression-of-gstp1-by-astaxanthin-in-human-prostate-lncap-cells
#1
Yuqing Yang, Francisco Fuentes, Limin Shu, Chao Wang, Doug Pung, Wenji Li, Chengyue Zhang, Yue Guo, Ah-Ng Kong
Astaxanthin (AST), a red dietary carotenoid, has synergistic antioxidant effects with polyunsaturated fatty acids at low concentrations via Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or Nrf2)/antioxidant response element (ARE) signaling. In addition, chromatin remodeling and DNA methylation-based gene silencing represent a common mechanism in prostate carcinogenesis and tumor progression from normal cells to pre-initiated cells and ultimately to invasive carcinoma. Therefore, the control of epigenetic modification and the transcriptional/translational control of the activation of Nrf2 and Nrf2-target genes, including glutathione S-transferases (GSTs), appear to be an important mechanism that protects cells against injuries from oxidative stress and cancer development...
December 2, 2016: AAPS Journal
https://www.readbyqxmd.com/read/27913364/an-intelligible-risk-stratification-model-based-on-pairwise-and-size-constrained-kmeans
#2
Longfei Han, Senlin Luo, Huaiqing Wang, Limin Pan, Xincheng Ma, Tiemei Zhang
Having a system to stratify individuals according to risk is key to clinical disease prevention, this allows individuals identified at different risk tiers benefit from further investigation and intervention. But the same risk score estimated for two different persons doesn't mean they need the same further investigation or represent the similarity health condition between two persons. Meanwhile, users still does not know a prior what most of the risk tiers are, and how many tiers should be found in risk stratification...
November 29, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27912962/the-influence-of-traditional-chinese-medicine-constitutions-on-the-potential-repair-capacity-after-osteonecrosis-of-the-femoral-head
#3
Tong Yu, Zhennan Zhang, Limin Xie, Xun Ke, Yang Liu
OBJECTIVES: To explore the effects of traditional Chinese medicine (TCM) constitutions on repair capacity after osteonecrosis of the femoral head (ONFH). DESIGN AND SETTING: Ninety-six patients with TCM constitutions of yang-deficiency, dampness-heat and/or blood-stasis were recruited from the orthopedic outpatient clinic of the Guang'anmen Hospital of the China Academy of Chinese Medical Science. Each patient underwent computed tomography (CT) examination of the hips, and CAD software was used to estimate proximal sclerosis ratios based on the CT images...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27911863/correlation-of-long-non-coding-rna-h19-expression-with-cisplatin-resistance-and-clinical-outcome-in-lung-adenocarcinoma
#4
Qi Wang, Ningning Cheng, Xuefei Li, Hui Pan, Chunyu Li, Shengxiang Ren, Chunxia Su, Weijing Cai, Chao Zhao, Limin Zhang, Caicun Zhou
The acquired drug resistance would influence the efficacy of cisplatin-based chemotherapy in non-small-cell lung cancer. The present study aimed to investigate the correlation of long non-coding RNA (lncRNA) H19 with cisplatin-resistance and clinical outcome in lung adenocarcinoma. In our study, the expression of H19 in cisplatin-resistant A549/DDP cells was unregulated. Knockdown of H19 restored the response of A549/DDP cells to cisplatin. H19-mediated chemosensitivity enhancement was associated with metastasis, induction of G0/G1 cell-cycle arrest, cell proliferation, and increased apoptosis...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27911550/comment-on-high-gain-submicrometer-optical-amplifier-at-near-infrared-communication-band
#5
Xue Feng, Zhicheng Liu, Jurgen Michel, Cun-Zheng Ning, Markus Pollnau, Limin Tong, Leijun Yin
No abstract text is available yet for this article.
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27902591/a-novel-indication-for-a-method-in-the-treatment-of-lumbar-tuberculosis-through-minimally-invasive-extreme-lateral-interbody-fusion-xlif-in-combination-with-percutaneous-pedicle-screws-fixation-in-an-elderly-patient-a-case-report
#6
Qiyou Wang, Yichun Xu, Ruiqiang Chen, Jianwen Dong, Bin Liu, Limin Rong
RATIONALE: To describe a novel indication for a method through minimally invasive extreme lateral interbody fusion (XLIF) in combination with percutaneous pedicle screwsfixation in the treatment of lumbar tuberculosis (TB) in an elderly patient, and its clinical efficacy and feasibility. Lumbar TB is a destructive form of TB. Antituberculous treatment should be started as early as possible. In some circumstances, however, surgical debridement with or without stabilization of the spine appears to be beneficial and may be recommended...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27902379/genetic-characterization-of-emergent-gii-17-norovirus-variants-from-2013-to-2015-in-nanjing-china
#7
Xuan Wang, Xuefei Du, Wei Yong, Mengkai Qiao, Min He, Limin Shi, Baofu Guo, Lei Hong, Yun Jiang, Guoxiang Xie, Jie Ding
During the 2014/15 winter season, a newly emergent GII.P17-GII.17 variant overwhelmed currently dominant GII.4 viruses, causing outbreaks of acute gastroenteritis in China and Japan. In Nanjing area, this novel GII.17 variant was first identified in a sporadic case of acute gastroenteritis in July 2013, 18 months ahead of reports from other parts of China. In this study, epidemiological features and genotyping of noroviruses from 2013 to 2015 were depicted. Twenty-eight local GII.17 sequences of capsid N-terminus originating from July 2013 to August 2015 were aligned, among which complete genome of seven strains obtained from two outbreaks and five sporadic cases was extensively characterized...
November 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27902231/kocuria-oceani-sp-nov-isolated-from-a-deep-sea-hydrothermal-plume
#8
Limin Zhang, Lijun Xi, Jisheng Ruan, Ying Huang
Three strains, FXJ8.095T, FXJ8.057 and H201 were isolated from deep-sea hydrothermal plume water collected at the Southwest Indian Ridge at a depth of 2800 m. Phylogenetic analysis based on 16S rRNA gene sequences showed that the isolates formed a closely related subcluster within the genus Kocuria. The 16S rRNA gene sequence of strain FXJ8.095T presented 99.90 and 99.60% similarities to those of the strains FXJ8.057 and H201, respectively, and 98.81, 98.75, 98.68 and 98.10% to those of 'Kocuria sediminis' JCM 17929, Kocuria flava HO-9041T, Kocuria turfanensis HO-9042T and Kocuria rosea JCM 11614T, respectively...
October 24, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27898293/metabolic-syndrome-among-adults-in-china-the-2010-china-noncommunicable-disease-surveillance
#9
Jieli Lu, Limin Wang, Mian Li, Yu Xu, Yong Jiang, Weiqing Wang, Jianhong Li, Shengquan Mi, Mei Zhang, Yichong Li, Tiange Wang, Min Xu, Zhiyun Zhao, Meng Dai, Shenghan Lai, Wenhua Zhao, Linhong Wang, Yufang Bi, Guang Ning
CONTEXT: In China, data on the prevalence of metabolic syndrome have been rare recently. OBJECTIVE: The objective of the study was to evaluate the prevalence of metabolic syndrome and its components in 2010. DESIGN, SETTING AND PARTICIPANTS: The study covered all 31 provinces of mainland China and consisted of a nationally representative population sample of 98,658 Chinese adults aged ≥ 18 years. Of these, 97,098 participants were eligible for the data analysis reported here...
November 29, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27893626/molecular-profiling-using-breast-cancer-subtype-to-plan-for-breast-reconstruction
#10
Lars Johan Sandberg, Mark W Clemens, W F Symmans, Vicente Valero, Abigail S Caudle, Benjamin Smith, Henry M Kuerer, Limin Hsu, Steven J Kronowitz
BACKGROUND: Molecular profiling using breast cancer subtype has an increasing role in the multidisciplinary care of the breast cancer patient. We sought to determine the role of breast cancer subtyping in breast reconstruction and specifically if breast cancer subtyping can determine the need for postmastectomy radiation therapy (PMRT) and predict recurrence-free survival (RFS) to plan for the timing and technique of breast reconstruction. METHODS: We reviewed prospectively collected data from 1931 reconstructed breasts in breast cancer patients who underwent mastectomy between November 1999 and December 2012...
November 21, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27889233/icaritin-induces-mitochondrial-apoptosis-by-up-regulating-mir-124-in-human-oral-squamous-cell-carcinoma-cells
#11
Limin Jin, Jinhong Miao, Yanjin Liu, Xingdan Li, Yaqiong Jie, Qianyun Niu, Xinguang Han
AIM OF THE STUDY: The present study is aimed to investigate the apoptosis-inducing effect of icaritin in human oral squamous cell carcinoma (OSCC) cells and the associated mechanisms. MATERIALS AND METHODS: KB and SCC9 cell lines were used as model cell lines. Effect of icaritin on apoptosis was analyzed by flow cytometry. The effect of icaritin on mitochondrial apoptotic pathway was demonstrated by loss of mitochondrial membrane potential and release of cytocrome C from mitochondria...
November 23, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27888421/triple-negative-breast-cancer-has-worse-overall-survival-and-cause-specific-survival-than-non-triple-negative-breast-cancer
#12
Xiaoxian Li, Jing Yang, Limin Peng, Aysegul A Sahin, Lei Huo, Kevin C Ward, Ruth O'Regan, Mylin A Torres, Jane L Meisel
PURPOSE: The current American Joint Committee on Cancer (AJCC) staging manual uses tumor size, lymph node, and metastatic status to stage breast cancer across different subtypes. We examined the prognosis of triple-negative breast cancer (TNBC) versus non-TNBC within the same stages and sub-stages to evaluate whether TNBC had worse prognosis than non-TNBC. METHODS: We reviewed the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) data and identified 158,358 patients diagnosed with breast cancer from 2010 to 2012...
November 25, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27885905/facilitating-terminal-discharge-fulfilling-the-hospitalised-patient-s-wish-for-home-death-in-the-final-hours
#13
Yung Ying Tan, Zhi Zhen Xu, Grace Sy Pang, Limin Qu, Yi Xu, Ai Min Zhang, Patricia Sh Neo
BACKGROUND: Terminal discharge (TD) is the rapid discharge of a hospitalised patient when death is imminent. Its time-limited nature makes it challenging, particularly for ward nurses. AIM: To report the development of a structured TD framework, and determine if the framework can expedite TD processes and improve nurses' experience in conducting TDs. METHODS: A 3-phase audit was carried out in a Singapore hospital. The baseline and post intervention audits evaluated the time taken for TD, incidence of prescription errors, continuity of care, and timeliness of equipment arrangement...
November 2, 2016: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/27885267/contributory-roles-of-two-l-lactate-dehydrogenases-for-l-lactic-acid-production-in-thermotolerant-bacillus-coagulans
#14
Lifan Sun, Caili Zhang, Pengcheng Lyu, Yanping Wang, Limin Wang, Bo Yu
Thermotolerant Bacillus coagulans is considered to be a more promising producer for bio-chemicals, due to its capacity to withstand harsh conditions. Two L-lactate dehydrogenase (LDH) encoding genes (ldhL1 and ldhL2) and one D-LDH encoding gene (ldhD) were annotated from the B. coagulans DSM1 genome. Transcriptional analysis revealed that the expression of ldhL2 was undetectable while the ldhL1 transcription level was much higher than that of ldhD at all growth phases. Deletion of the ldhL2 gene revealed no difference in fermentation profile compared to the wild-type strain, while ldhL1 single deletion or ldhL1ldhL2 double deletion completely blocked L-lactic acid production...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27877110/forward-genetic-screen-in-caenorhabditis-elegans-suggests-f57a10-2-and-acp-4-as-suppressors-of-c9orf72-related-phenotypes
#15
Xin Wang, Limin Hao, Taixiang Saur, Katelyn Joyal, Ying Zhao, Desheng Zhai, Jie Li, Mochtar Pribadi, Giovanni Coppola, Bruce M Cohen, Edgar A Buttner
An abnormally expanded GGGGCC repeat in C9ORF72 is the most frequent causal mutation associated with amyotrophic lateral sclerosis (ALS)/frontotemporal lobar degeneration (FTLD). Both gain-of-function (gf) and loss-of-function (lf) mechanisms have been involved in C9ORF72 related ALS/FTLD. The gf mechanism of C9ORF72 has been studied in various animal models but not in C. elegans. In the present study, we described mutant C9ORF72 modeling in C. elegans and report the finding of two suppressor genes. We made transgenes containing 9 or 29 repeats of GGGGCC in C9ORF72, driven by either the hsp-16 promoters or the unc-119 promoter...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27876623/identification-of-sea-perch-lateolabrax-japonicus-ribonucleoprotein-ptb-binding-1-involved-in-antiviral-immune-response-against-rgnnv
#16
Peng Jia, Wei Liu, Limin Chen, Yilin Jin, Jing Zhang, Kuntong Jia, Meisheng Yi
RIG-I-like receptors (RLRs) can recognize viral RNA and initiate innate antiviral response. In earlier studies, we demonstrated that RLRs were implicated in the antiviral immunity against RGNNV in the seawater fish sea perch (Lateolabrax japonicus). However, potential regulators of RLRs-mediated signaling pathways involved in RGNNV infection remain unclear. In this study, a novel ribonucleoprotein PTB-binding 1 (Raver1) of sea perch (LjRAVER1) was identified for the first time. The cDNA of LjRAVER1 was 4066 bp in length and encoded a deduced polypeptide of 733 amino acids...
November 20, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27875222/locally-supervised-deep-hybrid-model-for-scene-recognition
#17
Sheng Guo, Weilin Huang, Limin Wang, Yu Qiao
Convolutional neural networks (CNN) have recently achieved remarkable successes in various image classification and understanding tasks. The deep features obtained at the top fully-connected layer of the CNN (FC-features) exhibit rich global semantic information and are extremely effective in image classification. On the other hand, the convolutional features in the middle layers of the CNN also contain meaningful local information, but are not fully explored for image representation. In this paper, we propose a novel Locally-Supervised Deep Hybrid Model (LS-DHM) that effectively enhances and explores the convolutional features for scene recognition...
November 16, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/27875013/-icu-survivorship-a-constructivist-grounded-theory-of-surviving-critical-illness
#18
Susanne Kean, Lisa G Salisbury, Janice Rattray, Timothy S Walsh, Guro Huby, Pamela Ramsay
AIMS & OBJECTIVE: To theorise ICU survivorship after a critical illness based on longitudinal qualitative data. BACKGROUND: Increasingly patients survive episodes of critical illness. However, the short and long term impact of critical illness include physical, psychological, social and economic challenges long after hospital discharge. An appreciation is emerging that care needs to extend beyond critical illness to enable patients to reclaim their lives post-discharge with the term 'Survivorship' being increasingly used in this context...
November 22, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27873133/altered-expression-of-cxcl13-and-cxcr5-in-intractable-temporal-lobe-epilepsy-patients-and-pilocarpine-induced-epileptic-rats
#19
Ruohan Li, Limin Ma, Hao Huang, Shu Ou, Jinxian Yuan, Tao Xu, Xinyuan Yu, Xi Liu, Juan Yang, Yangmei Chen, Xi Peng
The mechanisms that underlie the pathogenesis of epilepsy are still unclear. Recent studies have indicated that inflammatory processes occurring in the brain are involved in a common and crucial mechanism in epileptogenesis. C-X-C motif chemokine ligand 13 (CXCL13) and its only receptor, C-X-C motif chemokine receptor 5 (CXCR5), are highly expressed in the central nervous system (CNS) and participate in inflammatory responses. The present study aimed to assess the expression of CXCL13 and CXCR5 in the brain tissues of both patients with intractable epilepsy (IE) and a rat model (lithium-pilocarpine) of temporal lobe epilepsy (TLE) to identify possible roles of the CXCL13-CXCR5 signaling pathway in epileptogenesis...
November 21, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27872514/the-role-of-interleukin-17-in-lung-cancer
#20
REVIEW
Feng Wu, Juanjuan Xu, Qi Huang, Jieli Han, Limin Duan, Jinshuo Fan, Zhilei Lv, Mengfei Guo, Guorong Hu, Lian Chen, Shuai Zhang, Xiaonan Tao, Wanli Ma, Yang Jin
Tumour-associated inflammation is a hallmark of malignant carcinomas, and lung cancer is a typical inflammation-associated carcinoma. Interleukin-17 (IL-17) is an important inflammatory cytokine that plays an important role in chronic inflammatory and autoimmune diseases and in inflammation-associated tumours. Numerous studies have shown that IL-17 directly or indirectly promotes tumour angiogenesis and cell proliferation and that it inhibits apoptosis via the activation of inflammatory signalling pathways...
2016: Mediators of Inflammation
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