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https://www.readbyqxmd.com/read/29149738/associations-of-urinary-polycyclic-aromatic-hydrocarbon-metabolites-with-fractional-exhaled-nitric-oxide-and-exhaled-carbon-monoxide-a-cross-sectional-study
#1
Yun Zhou, Yuewei Liu, Huizhen Sun, Jixuan Ma, Lili Xiao, Limin Cao, Wei Li, Bin Wang, Jing Yuan, Weihong Chen
Exposure to Polycyclic aromatic hydrocarbons (PAHs) has been associated with inflammatory responses. Fractional exhaled nitric oxide (FeNO) and exhaled carbon monoxide (eCO) are both important inflammatory mediators especially in airways. However, few studies have investigated associations of PAH exposures with FeNO or eCO. Therefore, we aimed to quantify the associations of urinary PAH metabolites with FeNO and eCO levels, and investigate their potential effect modifiers by linear mixed models among 4133 participants from the Wuhan-Zhuhai cohort in China...
November 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29149473/exploring-communication-during-the-journey-from-noticing-bodily-changes-to-a-diagnosis-of-endometrial-cancer
#2
Catherine Cook, Margaret Brunton, Tepora Pukepuke, Ai Ling Tan
AIMS AND OBJECTIVES: To understand women's perspectives about the trajectory from first bodily changes to diagnosis. BACKGROUND: With endometrial cancer, as with all gynaecological cancers, early diagnosis is key to successful outcomes. However, women do not always seek clinical advice early. Previously, this gap has been referred to as a 'delay', blamed on fear or refusal to acknowledge symptoms. METHODS: A qualitative research project which involved face-to-face interviews with 16 women who had presented with symptoms of endometrial cancer...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29145272/the-efficiency-of-intravenous-acetaminophen-for-pain-control-following-total-knee-and-hip-arthroplasty-a-systematic-review-and-meta-analysis
#3
Limin Liang, Ying Cai, Aixiang Li, Chuangen Ma
BACKGROUND: This meta-analysis aimed to evaluate the efficiency and safety of intravenous acetaminophen as an adjunct to multimodal analgesia for pain control after total joint arthroplasty (TJA). METHODS: PubMed, Embase, Web of science, Medline, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) and non-RCTs were included. Fixed/random effect model was used according to the heterogeneity tested by I statistic. Meta-analysis was performed using Stata 11...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145206/microrna-expression-profiling-of-pancreatic-cancer-cell-line-l3-6p1-following-b7-h4-knockdown
#4
Yun Qian, Limin Feng, Weigen Wu, Tianhao Weng, Chenyu Hu, Bo Hong, Frederick X C Wang, Lingwei Shen, Qi Wang, Xin Jin, Hangping Yao
BACKGROUND/AIMS: Co-stimulating molecule B7-H4 regulates T cell-mediated immune responses, participates in tumor immune escape, and promotes the proliferation and metastasis of pancreatic cancer cells. However, the specific mechanisms are unclear. MicroRNAs (miRNAs) participated in the pathogenesis and progression of cancer. METHODS: In this study, a microarray technique was used to screen B7-H4-related differentially expressed miRNAs in a pancreatic cancer cell line find those associated with pancreatic cancer...
November 17, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29144394/estimating-crop-area-at-county-level-on-the-north-china-plain-with-an-indirect-sampling-of-segments-and-an-adapted-regression-estimator
#5
Qinghan Dong, Jia Liu, Limin Wang, Zhongxin Chen, Javier Gallego
Image classifications, including sub-pixel analysis, are often used to estimate crop acreage directly. However, this type of assessment often leads to a biased estimation, because commission and omission errors generally do not compensate for each other. Regression estimators combine remote sensing information with more accurate ground data on a field sample, and can result in more accurate and cost-effective assessments of crop acreage. In this pilot study, which aims to produce crop statistics in Guoyang County, the area frame sampling approach is adapted to a strip-like cropping pattern on the North China Plain...
November 16, 2017: Sensors
https://www.readbyqxmd.com/read/29144380/a-passive-and-wireless-sensor-for-bone-plate-strain-monitoring
#6
Yisong Tan, Jiale Hu, Limin Ren, Jianhua Zhu, Jiaqi Yang, Di Liu
This paper reports on a sensor for monitoring bone plate strain in real time. The detected bone plate strain could be used for judging the healing state of fractures in patients. The sensor consists of a magnetoelastic material, which can be wirelessly connected and passively embedded. In order to verify the effectiveness of the sensor, a tibia-bone plate-screw (TBS) model was established using the finite element analysis method. A variation of the bone plate strain was obtained via this model. A goat hindquarter tibia was selected as the bone fracture model in the experiment...
November 16, 2017: Sensors
https://www.readbyqxmd.com/read/29140293/the-trends-in-cardiovascular-diseases-and-respiratory-diseases-mortality-in-urban-and-rural-china-1990-2015
#7
Weiwei Sun, Yun Zhou, Zhuang Zhang, Limin Cao, Weihong Chen
With the rapid development of the economy over the past 20 years, the mortality rates from cardiovascular diseases (CVDs) and respiratory diseases (RDs) have changed in China. This study aimed to analyze the trends of mortality rates and years of life lost (YLLs) from CVDs and RDs in the rural and urban population from 1990 to 2015. Using data from Chinese yearbooks, joinpoint regression analysis was employed to estimate the annual percent change (APC) of mortality rates from CVDs and RDs. YLLs due to CVDs and RDs were calculated by a standard method, adopting recommended standard life expectancy at birth values of 80 years for men and 82...
November 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29139370/perianal-ulcer-in-an-asian-man
#8
Nilanthy Sharon Anthony Pillai, Choon Chiat Oh, Michelle Chan Mei Fung, Limin Wijaya
A 79-year-old Chinese man presented with a 2-month history of pruritic, tender ulceration covering his perianal region. He was initially treated with oral amoxicillin/clavulanic acid and vancyclovir, with no improvement. His history included hypertension. On physical examination, there was a 1.5-cm solitary, pink shallow ulcer with a tender erythematous base on the right side of the buttock cleft (Figure 1).
2017: Skinmed
https://www.readbyqxmd.com/read/29138564/zinc-oxide-nanoparticles-induce-toxic-responses-in-human-neuroblastoma-shsy5y-cells-in-a-size-dependent-manner
#9
Jia Liu, Yiyuan Kang, Suhan Yin, Bin Song, Limin Wei, Liangjiao Chen, Longquan Shao
Due to the widespread applications of zinc oxide nanoparticles (ZnO NPs), the potential exposure of workers, consumers, and scientists to these particles has increased. This potential for exposure has attracted extensive attention in the science community. Many studies have examined the toxicological profile of ZnO NPs in the immune system, digestive system, however, information regarding the toxicity of ZnO NPs in the nervous system is scarce. In this study, we detected the cytotoxicity of two types of ZnO NPs of various sizes - ZnO(a) NPs and ZnO(b) NPs - and we characterized the shedding ability of zinc ions within culture medium and the cytoplasm...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29137974/effects-and-mechanisms-of-matrix-metalloproteinase2-on-neural-differentiation-of-induced-pluripotent-stem-cells
#10
Tao Shu, Chang Liu, Mao Pang, Juan Wang, Bin Liu, Wei Zhou, Xuan Wang, Tao Wu, Qiyou Wang, Limin Rong
Induced pluripotent stem cells (iPSCs) possess the potential to differentiate into neural lineage cells. Matrix metalloproteinase 2 (MMP2), an endopeptidase in the extracellular matrix, has been shown to protect neural cells from injury. However, the mechanisms and effects of MMP2 on neural differentiation of iPSCs remain poorly understood. Here, we demonstrated a role for MMP2 in the differentiation of iPSCs to neurons via the AKT pathway. Treatment of iPSCs with MMP2 promoted their proliferation and differentiation into neural stem cells (NSCs), and then into neurons...
November 11, 2017: Brain Research
https://www.readbyqxmd.com/read/29137758/droplets-banding-characteristics-of-water-in-oil-emulsion-under-ultrasonic-standing-waves
#11
Xiaoming Luo, Juhang Cao, Haoran Yin, Haipeng Yan, Limin He
Droplets banding is critical to emulsion separation under ultrasonic irradiation as it can greatly improve the separation efficiency. In this paper, the formation process of droplets banding under ultrasonic standing waves was precisely captured by high-speed microscopic photography; by processing the images, the droplets banding characteristics, including the banding formation time and banding interval, were extracted. Then the effects of acoustic intensity, frequency, droplet size, and physical properties of oil and water on the droplets banding characteristics were discussed in details...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29135584/concomitant-medication-polypharmacy-interactions-and-imperfect-adherence-are-common-in-australian-adults-on-suppressive-art
#12
Krista J Siefried, Limin Mao, Lucette A Cysique, John Rule, Michelle L Giles, Don E Smith, James Mcmahon, Tim R Read, Catriona Ooi, Ban K Tee, Mark Bloch, John de Wit, Andrew Carr
OBJECTIVES: We quantified concomitant medication (CM) polypharmacy, pharmacokinetic (PK) and pharmacodynamic (PD) interactions, adverse effects and adherence in Australian adults on effective ART. DESIGN: Cross-sectional. METHODS: Patients recruited into a nation-wide cohort and assessed for prevalence and type of CM (including polypharmacy, defined as ≥5 CMs), PK or PD interactions, potential CM adverse effects and CM adherence. Factors associated with CM polypharmacy and with imperfect adherence were identified using multivariable logistic regression...
November 10, 2017: AIDS
https://www.readbyqxmd.com/read/29133092/cloning-and-biochemical-characterization-of-a-novel-%C3%AE%C2%BA-carrageenase-from-newly-isolated-marine-bacterium-pedobacter-hainanensis-nj-02
#13
Benwei Zhu, Fang Ni, Limin Ning, Zhong Yao, Yuguang Du
Enzymatic preparation of carrageenan oligosaccharides has drawn increasing attention due to its advantages of mild reaction conditions and excellent product-specificity. A novel gene (CgkA) encoding a new κ-carrageenase was cloned, heterogeneously expressed and characterized from a newly isolated marine bacterium Pedobacter hainanensis NJ-02. It consisted of 1539bp and encoded 512 amino acid residues with a molecular weight of 57.12kDa. Multiple alignment analysis indicated that CgkA belongs to glycoside hydrolase (GH) family 16 and was most homologous to κ-carrageenase of Zobellia sp...
November 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29132372/hepatitis-b-virus-inhibits-the-in-vivo-and-in-vitro-synthesis-and-secretion-of-apolipoprotein-c3
#14
Chengliang Zhu, Hengcheng Zhu, Hui Song, Limin Xu, Longxuan Li, Fang Liu, Xinghui Liu
BACKGROUND: Hepatitis B virus (HBV) infection in the body can damage liver cells and cause disorders in blood lipid metabolism. Apolipoprotein C3 (ApoC3) plays an important role in the regulation of lipid metabolism, but no study on the HBV regulation of ApoC3 has been reported. This purpose of this study was to investigate the effect of HBV on ApoC3 expression and its regulatory mechanism. METHODS: The expression levels of ApoC3 mRNA and protein in the human hepatoma cell lines HepG2 and HepG2...
November 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29127803/development-of-thresholds-of-excess-toxicity-for-environmental-species-and-their-application-to-identification-of-modes-of-acute-toxic-action
#15
Jin J Li, Xu J Zhang, Yi Yang, Tao Huang, Chao Li, Limin Su, Yuan H Zhao, Mark T D Cronin
The acute toxicity of organic pollutants to fish, Daphnia magna, Tetrahymena pyriformis, and Vibrio fischeri was investigated. The results indicated that the Toxicity Ratio (TR) threshold of log TR =1, which has been based on the distribution of toxicity data to fish, can also be used to discriminate reactive or specifically acting compounds from baseline narcotics for Daphnia magna and Vibrio fischeri. A log TR=0.84 is proposed for Tetrahymena pyriformis following investigation of the relationships between the species sensitivity and the absolute averaged residuals (AAR) between the predicted baseline toxicity and the experimental toxicity...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29126982/effects-of-chronic-social-defeat-on-social-behaviors-in-adult-female-mandarin-voles-microtus-mandarinus-involvement-of-the-oxytocin-system-in-the-nucleus-accumbens
#16
Limin Wang, Wenjuan Hou, Zhixiong He, Wei Yuan, Jinfeng Yang, Yang Yang, Rui Jia, Zhenxiang Zhu, Yue Zhou, Fadao Tai
Chronic social defeat affects many aspects of behavior. Most previous studies have focused on effects on males and defeat during adolescence. The extents to which chronic social defeat can impact female social behavior in adulthood and the neural mechanisms of such effects are poorly understood. Using highly social and aggressive female mandarin voles (Microtus mandarinus), the present study found that chronic social defeat reduced social preference in adult females, and that the defeated voles exhibited a high level of freeze, self-grooming and defensive behavior, as well as reduced exploration, intimacy and aggression during social interactions...
November 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29123400/comparison-of-spontaneous-brain-activity-revealed-by-regional-homogeneity-in-aqp4-igg-neuromyelitis-optica-optic-neuritis-versus-mog-igg-optic-neuritis-patients-a-resting-state-functional-mri-study
#17
Junqing Wang, Yuan Tian, Yi Shao, Hui Feng, Limin Qin, Weiwei Xu, Hongjuan Liu, Quangang Xu, Shihui Wei, Lin Ma
Objective: Many previous studies have demonstrated that neuromyelitis optica (NMO) patients have abnormalities of brain anatomy and function. However, differences in spontaneous brain activity between myelin oligodendrocyte glycoprotein (MOG)-IgG ON and aquaporin 4(AQP4)-neuromyelitis optica-optic neuritis (ON) remain unknown. In the current study, we investigated the brain neural homogeneity in MOG-IgG ON versus AQP4-IgG NMO-ON subjects by regional homogeneity (ReHo) method using magnetic resonance imaging (MRI)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29121163/gene-expression-profiling-reveals-heterogeneity-of-perivascular-adipose-tissues-surrounding-coronary-and-internal-thoracic-arteries
#18
Danbo Lu, Wei Wang, Limin Xia, Pu Xia, Yan Yan
The internal thoracic artery (ITA) that differs from coronary artery (CA), rarely develops atherosclerosis. Understanding the mechanism underlying such a difference will help to pave a new way to the prevention and treatment of the disease. We hypothesize herein that the difference in susceptibility to atherosclerosis between CA and ITA is attributable to the heterogeneity of perivascular adipose tissues (PVATs) surrounding these two kinds of arteries, i.e. PVAT-CA and PVAT-ITA. We isolated PVAT from eight patients of coronary heart disease (CHD) and four non-CHD patients...
November 7, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29116999/treatment-outcome-of-combined-continuous-venovenous-hemofiltration-and-hemoperfusion-in-acute-paraquat-poisoning-a-prospective-controlled-trial
#19
Changbin Li, Dayong Hu, Wen Xue, Xinhua Li, Zhen Wang, Zisheng Ai, Yaxiang Song, Xinying Liu, Jiafeng Cheng, Shuling Fan, Limin Zhao, Liya Wang, Chandra Mohan, Ai Peng
OBJECTIVES: To investigate whether combined continuous venovenous hemofiltration and hemoperfusion among paraquat-poisoned patients would improve survival. DESIGN: Prospective, controlled interventional study over 4 years. SETTING: Single, tertiary, academic medical center. PATIENTS: We recruited patients admitted to Shanghai Tenth People's Hospital within 48 hours after paraquat ingestion. Exclusions were under 14 years old, ingestion of paraquat with other toxicants, pregnant, a history of chronic pulmonary disease, psychosis, hyperthyroidism, or diabetes with impaired liver or renal function...
November 7, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29115030/developing-an-efficient-biosensor-for-in-vivo-quantification-of-cu-and-ph-in-the-brain-based-on-rational-design-and-synthesis-of-recognition-molecules
#20
Wei Liu, Hui Dong, Limin Zhang, Yang Tian
Herein, an efficient biosensor was created for ratiometric monitoring of Cu+ and pH in the brain using both current and potential outputs. A series of NS4s derivatives was designed for specific recognition of Cu+. After systematically evaluating the electrochemical parameters of Cu+ oxidation by tuning alkyl chain length, polyaromatic structure, and substitute group site of NS4, NS4-C1 was finally optimized to detect Cu+ owing to the most negative potential and the largest current density. Meanwhile, AQ was designed as a selective pH recognition, while ABTS was employed as an inner reference...
November 8, 2017: Angewandte Chemie
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