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https://www.readbyqxmd.com/read/28811862/allergic-profiles-of-mothers-and-fathers-in-the-japan-environment-and-children-s-study-jecs-a-nationwide-birth-cohort-study
#1
Kiwako Yamamoto-Hanada, Limin Yang, Kazue Ishitsuka, Tadayuki Ayabe, Hidetoshi Mezawa, Mizuho Konishi, Testsuo Shoda, Kenji Matsumoto, Hirohisa Saito, Yukihiro Ohya
BACKGROUND: The Japan Environment and Children's Study (JECS) is a nationwide, multicenter, prospective birth cohort investigation launched by the Ministry of Environment in Japan. The purpose of the JECS is to evaluate the influence of prenatal and postnatal exposures to environmental factors on the postnatal health of the children. In this study, we evaluated the allergic characteristics of parents within the JECS cohort. METHODS: This study covered a wide geographical area and encompassed 15 regional centers...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28811793/effectiveness-and-safety-of-percutaneous-vertebroplasty-in-the-treatment-of-spinal-metastatic-tumor
#2
Yilin Liu, Yuqiang Wang, Liang Zhao, Ruipeng Song, Hongyu Tan, Limin Wang
OBJECTIVE: To evaluate the effectiveness, safety and feasibility of percutaneous vertebroplasty in the treatment of spinal metastatic tumor. METHODS: Thirty-four patients with spinal metastatic tumor who received treatment in the First Affiliated Hospital of Zhengzhou University from May 2014 to June 2015 were selected. Totally fifty diseased vertebrae were treated by percutaneous vertebroplasty. The curative effects were evaluated according to visual analogue scale (VAS) score, Oswestry Dability Index (ODI) and dose of pain reliever...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28810633/clinical-significance-of-5-and-6-carboxyfluorescein-diacetate-succinimidyl-ester-labeled-microspheres-for-detecting-endothelial-progenitor-cells-in-human-peripheral-blood
#3
Chaolin Qiu, Denghai Zhang, Yongbin Chi, Qing Chen, Limin Xu, Qiuhua Xie
The aims of the present study were to establish a single-platform flow cytometry method using 5-(and 6)-carboxyfluorescein diacetate succinimidyl ester (CFSE)-labeled microspheres as the reference for determining endothelial progenitor cell (EPC) number and to evaluate the efficacy of this detection method. Single-platform flow cytometry was used to count cell numbers using CFSE-stained fluorescent microspheres as the internal reference and the EPC numbers in specimens using this novel method were compared with an in vitro clonogenic counting assay...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810598/differentially-methylated-regions-in-patients-with-rheumatic-heart-disease-and-secondary-pulmonary-arterial-hypertension
#4
Dawei Zheng, Xiaoying Chen, Ni Li, Lebo Sun, Qingyun Zhou, Huoshun Shi, Guodong Xu, Jing Liu, Limin Xu, Shiwei Duan, Guofeng Shao
The aim of the present study was to identify differentially methylated regions (DMRs) in patients with rheumatic heart disease and secondary pulmonary arterial hypertension (RHD-PAH). A genome-wide DNA methylation assay was performed between 6 patients with RHD-PAH and 6 healthy controls using an Illumina Infinium HumanMethylation450 BeadChip kit. The Limma software package was subsequently used to identify significant DMRs. A total of 40 hypome-thylated and 64 hypermethylated CpG sites were identified between the RHD-PAH group and the control group...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28809441/design-and-fabrication-of-temperature-sensitive-nanogels-with-controlled-drug-release-properties-for-enhanced-photothermal-sterilization
#5
Luoyuan Li, Limin Fu, Jing Zhou, Xicheng Ai, Jianping Zhang
Excessive free radicals can cause normal protein metamorphic, and further damage healthy cells, while the damaged cells are more prone to infection with pathogenic bacteria. For better removing excessive free radicals and deleterious bacteria from human body, it is urgently needed to develop synergistic antioxidant and antibacterial agents. Herein, we designed novel temperature-sensitive, curcumin (Cur)-loaded nanogels to scavenge reactive oxygen species and kill pathogenic bacteria. Photothermal sterilization, different from traditional antibiotics, is a promising and effective treatment for inactivation of pathogenic bacteria...
August 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28806070/high-levels-of-daytime-molecular-chlorine-and-nitryl-chloride-at-a-rural-site-on-the-north-china-plain
#6
Xiaoxi Liu, Hang Qu, Lewis Gregory Huey, Yuhang Wang, Steven Sjostedt, Limin Zeng, Keding Lu, Yusheng Wu, Min Hu, Min Shao, Tong Zhu, Yuanhang Zhang
Molecular chlorine (Cl2) and nitryl chloride (ClNO2) concentrations were measured using chemical ionization mass spectrometry at a rural site over the North China Plain during June 2014. High levels of daytime Cl2 up to ~450 pptv were observed. The average diurnal Cl2 mixing ratios showed a maximum around noon at ~100 pptv. ClNO2 exhibited a strong diurnal variation with early morning maxima reaching ppbv levels and afternoon minima sustained above 60 pptv. A moderate correlation (R(2)=0.31) between Cl2 and sulfur dioxide was observed, perhaps indicating a role for power plant emissions in the generation of the observed chlorine...
August 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28801889/strategies-of-minimally-invasive-treatment-for-intrahepatic-and-extrahepatic-bile-duct-stones
#7
Zongming Zhang, Zhuo Liu, Limin Liu, Mengmeng Song, Chong Zhang, Hongwei Yu, Baijiang Wan, Mingwen Zhu, Zixu Liu, Hai Deng, Haiming Yuan, Haiyan Yang, Wenping Wei, Yue Zhao
Cholelithiasis is a kind of common and multiple diseases. In recent years, traditional laparotomy has been challenged by a minimally invasive surgery. Through literature review, the therapeutic method, effect, and complications of minimally invasive treatment of intrahepatic and extrahepatic bile duct stones by combining our practical experience were summarized as follows. (1) For intrahepatic bile duct stones, the operation may be selected by laparoscopic liver resection, laparoscopic common bile duct exploration (LCBDE), or percutaneous transhepatic cholangioscopy...
August 12, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28797938/bihc-a-t-cell-engaging-bispecific-recombinant-antibody-has-potent-cytotoxic-activity-against-her2-tumor-cells
#8
Jieyu Xing, Limin Lin, Jing Li, Jiayu Liu, Changhua Zhou, Haitao Pan, Rui Shu, Bin Dong, Donglin Cao, Qing Li, Zhong Wang
Among different cancer immunotherapy approaches, bispecific antibodies (BsAbs) are of great interest due to their ability to recruit immune cells to kill tumor cells directly. Various BsAbs against Her2 tumor cells have been proposed with potent cytotoxic activities. However, most of these formats require extensive processing to obtain heterodimeric bispecific antibodies. In this study, we describe a bispecific antibody, BiHC (bispecific Her2-CD3 antibody), constructed with a single-domain anti-Her2 and a single-chain Fv (variable fragment) of anti-CD3 in an IgG-like format...
August 7, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28794353/revascularization-of-left-coronary-system-using-a-skeletonized-left-internal-mammary-artery%C3%A3-sequential-vs-separate-grafting
#9
Qiang Ji, YunQing Shi, LiMin Xia, RunHua Ma, JinQiang Shen, Hao Lai, WenJun Ding, ChunSheng Wang
BACKGROUND: To evaluate in-hospital and mid-term outcomes of sequential vs. separate grafting of in situ skeletonized left internal mammary artery (LIMA) to the left coronary system in a single-center, propensity-matched study.Methods and Results:After propensity score-matching, 120 pairs of patients undergoing first scheduled isolated coronary artery bypass grafting (CABG) with in situ skeletonized LIMA grafting to the left anterior descending artery (LAD) territory were entered into a sequential group (sequential grafting of LIMA to the diagonal artery and then to the LAD) or a control group (separate grafting of LIMA to the LAD)...
August 9, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28790331/3d-printed-personalized-titanium-plates-improve-clinical-outcome-in-microwave-ablation-of-bone-tumors-around-the-knee
#10
Limin Ma, Ye Zhou, Ye Zhu, Zefeng Lin, Lingling Chen, Yu Zhang, Hong Xia, Chuanbin Mao
Microwave ablation has been widely accepted in treating bone tumor. However, its procedure is time-consuming and usually results in postoperative fractures. To solve this problem, we designed and fabricated titanium plates customized to the patients' bone structures. The personalized titanium plates were then used for fixation after the removal of tumorous tissue. Specifically, 3D models of tumor-bearing bone segments were constructed by using computed tomography (CT) and magnetic resonance imaging (MRI). The 3D models were used to design the personalized titanium plates...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28777532/design-and-synthesis-of-hierarchical-sio2-c-tio2-hollow-spheres-for-high-performance-supercapacitors
#11
Ying Zhang, Yan Zhao, Shunsheng Cao, Zhengliang Yin, Li Cheng, Limin Wu
TiO2 has been widely investigated as electrodes materials due to its long cycle life and good durability, but the relatively low theoretical capacity restricts its practical application. Herein, we design and synthesize a novel hierarchical SiO2@C/TiO2 (HSCT) hollow spheres via a template-directed method. This unique HSCT hollow spheres combine both advantages from both TiO2 such as cycle stability and SiO2 with high accessible area and ionic transport. Especially, the C layer between SiO2 and TiO2 can improve the electrical conductivity and accelerate the charge transfer from outer TiO2 to inner SiO2...
August 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28775231/prognostic-and-clinicopathological-significance-of-muc-expression-in-head-and-neck-cancer-a-systematic-review-and-meta-analysis
#12
REVIEW
Hao Lu, Dan Liang, Yun Zhu, Wanlin Xu, Kaihua Zhou, Limin Liu, Shengwen Liu, Wenjun Yang
The prognostic value of mucins expression in patients with head and neck cancer (HNC) remains controversial. To address this, a meta-analysis was performed to systematically evaluate prognostic significance of mucins expression in HNC. Electronic and manual searches were performed and a total of 20 studies including 2046 patients were selected for the final analysis. Increased mucins expression was associated with unfavorable overall survival in HNC patients (HR=1.83, 95% CI: 1.43-2.33, p=0.000). Mucins overexpression was also in correlation with more advanced TNM stage (RR=0...
July 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28774176/spectrally-resolved-functional-super-resolution-microscopy-reveals-nanoscale-compositional-heterogeneity-in-live-cell-membranes
#13
Seonah Moon, Rui Yan, Samuel J Kenny, Yennie Shyu, Limin Xiang, Wan Li, Ke Xu
By recording the full fluorescence spectra and super-resolved positions of ∼10(6) individual polarity-sensing solvatochromic molecules, we reveal compositional heterogeneity in the membranes of live mammalian cells with single-molecule sensitivity and ∼30 nm spatial resolution. This allowed us to unveil distinct polarity characteristics of the plasma membrane and the membranes of nanoscale intracellular organelles, a result we found to be due to differences in cholesterol levels. Within the plasma membrane, we observed the formation of low-polarity, raft-like nanodomains upon cholesterol addition or cholera-toxin treatment, but found this nanoscale phase separation absent in native cells...
August 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28774063/experimental-and-theoretical-analysis-of-sound-absorption-properties-of-finely-perforated-wooden-panels
#14
Boqi Song, Limin Peng, Feng Fu, Meihong Liu, Houjiang Zhang
Perforated wooden panels are typically utilized as a resonant sound absorbing material in indoor noise control. In this paper, the absorption properties of wooden panels perforated with tiny holes of 1-3 mm diameter were studied both experimentally and theoretically. The Maa-MPP (micro perforated panels) model and the Maa-Flex model were applied to predict the absorption regularities of finely perforated wooden panels. A relative impedance comparison and full-factorial experiments were carried out to verify the feasibility of the theoretical models...
November 22, 2016: Materials
https://www.readbyqxmd.com/read/28772705/liv%C3%A2-o%C3%A2-polytriphenylamine-composites-with-enhanced-electrochemical-performances-as-cathode-materials-for-rechargeable-lithium-batteries
#15
Wenjuan Li, Limin Zhu, Ziheng Yu, Lingling Xie, Xiaoyu Cao
LiV₃O₈/polytriphenylamine composites are synthesized by a chemical oxidative polymerization process and applied as cathode materials for rechargeable lithium batteries (RLB). The structure, morphology, and electrochemical performances of the composites are characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, galvanostatic discharge/charge tests, and electrochemical impedance spectroscopy. It was found that the polytriphenylamine particles were composited with LiV₃O₈ nanorods which acted as a protective barrier against the side reaction of LiV₃O₈, as well as a conductive network to reduce the reaction resistance among the LiV₃O₈ particles...
March 26, 2017: Materials
https://www.readbyqxmd.com/read/28770609/a-dual-ratiometric-fluorescent-nanoprobe-for-visualizing-the-dynamic-process-of-ph-and-superoxide-anion-changes-in-autophagy-and-apoptosis
#16
Limin Yang, Yuanyuan Chen, Zhengze Yu, Wei Pan, Hongyu Wang, Na Li, Bo Tang
Autophagy and apoptosis are closely associated with various pathological and physiological processes in cell cycles. Investigating the dynamic changes of intracellular active molecules in autophagy and apoptosis is of great significance for clarifying their interrelationship and regulating mechanism in many diseases. In this study, we develop a dual-ratiometric fluorescent nanoprobe for quantitatively differentiating the dynamic process of superoxide anion (O2•-) and pH changes in autophagy and apoptosis in HeLa cells...
August 3, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28768242/slc3a2-antigen-of-mab-3g9-promotes-migration-and-invasion-by-upregulating-of-mucins-in-gastric-cancer
#17
Shanshan Wang, Haibo Han, Ying Hu, Wei Yang, Yunwei Lv, Limin Wang, Lianhai Zhang, Jiafu Ji
Solute carrier family 3 member 2 (SLC3A2) has been reported to be highly expressed in a variety of carcinomas. However, the function of SLC3A2 in gastric carcinoma (GC) has not been well explored. Monoclonal antibody (mAb) 3G9, generated from immunogen of various human GC cell lines, has been shown to bind to GC tissues specifically. In this study, we identified the target antigen of mAb 3G9 as SLC3A2, and detected the expression profile of SLC3A2 in a panel of gastric cancer cell lines and GC tumor tissues...
July 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28767723/improving-rice-population-productivity-by-reducing-nitrogen-rate-and-increasing-plant-density
#18
Guangli Tian, Limin Gao, Yali Kong, Xiangyu Hu, Kailiu Xie, Ruiqing Zhang, Ning Ling, Qirong Shen, Shiwei Guo
In terms of tillering potential, the aboveground portions of rice are significantly influenced by the nitrogen level (NL) and transplant density (TD). To obtain a suitable combination of NL and TD, five NLs (0, 90, 180, 270 and 360 kg ha-1) and two TDs [high density (HD), 32.5×104 hills ha-1; low density (LD), 25.5×104 hills ha-1] were used in the rice experiments during 2012 to 2014, in Jiangsu, China. The results showed the highest grain yield of rice obtained at HD and LD when N supply was 180 and 270 kg ha-1, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28767416/effect-of-subclinical-hypothyroidism-on-the-skeletal-system-and-improvement-with-short-term-thyroxine-therapy
#19
Cuixia Gao, Yu Wang, Tingting Li, Jing Huang, Limin Tian
The purpose of the study was to observe changes in the skeletal system of rats with subclinical hypothyroidism (SCH) and to determine whether L-thyroxine (L-T4) administration suppresses those changes. Sixty male Wistar rats were randomly divided into control, SCH, and SCH+T4 groups. SCH was induced in rats by administration of methimazole (MMI), and rats in the SCH+T4 group were treated with L-T4 after 45 days of MMI administration. The SCH group had higher thyroid-stimulating hormone (TSH) level than the control and SCH+T4 groups...
July 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28767413/combination-of-aqp1-and-%C3%AE-catenin-expression-is-an-independent-prognosis-factor-in-astrocytoma-patients
#20
Huikun Zhang, Fengxia Qin, Limin Yang, Jia He, Xiaoli Liu, Ying Shao, Zhifang Guo, Ming Zhang, Wenliang Li, Li Fu, Feng Gu, Yongjie Ma
Previous research usually focused on single protein or gene in tumor development, actually highly heterogeneous nature and different signaling pathways largely contribute to tumor progression and tumor patients' outcomes. Therefore, using combinatorial biomarkers to evaluate the prognostic features and guide management is gradually accepted and urgently needed. β-catenin is a well-known crucial factor in astrocytoma progression and it is involved in aquaporin1 (AQP1) mediated cell migration. In this study, we revealed the function of AQP1 in astrocytoma progression and provided the first clinical evidence that AQP1 expression was positively correlated with β-catenin...
July 26, 2017: Oncotarget
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