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https://www.readbyqxmd.com/read/28223434/spatial-analysis-of-regional-factors-and-lung-cancer-mortality-in-china-1973-2013
#1
Xiaoping Shen, Limin Wang, Li Zhu
BACKGROUND: China's lung cancer crude death rate has increased 6.9-fold from 1973 to 2014. During this time, the country experienced extremely rapid economic growth and social change. It is important to understand the effects of risk factors on Lung Cancer Mortality (LCM) for better allocation of limited resources of cancer prevention and control in China. METHODS: Using three nationwide mortality surveys from 1973 to 2005, Global Health Data Exchange data in 2013, three nationwide smoking surveys from 1984 to 2013, four population censuses from 1964 to 2000, and other datasets, we have compiled datasets and developed spatial random effect models to assess the association of various area level contributing factors on LCM...
February 21, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28223275/vascular-cxcr4-expression-promotes-vessel-sprouting-and-sensitivity-to-sorafenib-treatment-in-hepatocellular-carcinoma
#2
Jing Xu, Jing Liang, Ya-Ming Meng, Jing Yan, Xin-Juan Yu, Chao-Qun Liu, Li Xu, Shi-Mei Zhuang, Limin Zheng
PURPOSE: Chemokine receptor CXCR4 is known to be involved in both developmental and adult angiogenesis; however, its role in tumor angiogenesis remains largely unknown. Here the role of vascular CXCR4 in regulating vascular structure in HCC was assessed and the clinical value of CXCR4 was explored. EXPERIMENTAL DESIGN: The expression of CXCR4 in hepatocellular carcinoma (HCC) was determined by immunohistochemistry and immunofluorescence. Characteristics of CXCR4+ cells were determined by in vitro and mice experiments...
February 21, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28221355/corrigendum-intermediate-tunnelling-hopping-regime-in-dna-charge-transport
#3
Limin Xiang, Julio L Palma, Christopher Bruot, Vladimiro Mujica, Mark A Ratner, Nongjian Tao
No abstract text is available yet for this article.
February 21, 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28221001/synthesis-of-dual-stimuli-responsive-microcontainers-with-two-payloads-in-different-storage-spaces-for-preprogrammable-release
#4
Ying Cong, Qiuju Li, Min Chen, Limin Wu
Stimuli-responsive microcontainers have become a major topic of interest, from fundamental aspects to applications in materials science. However, microcontainers that enable the loading of multiple species and programmable release are mostly unexplored. Herein, we describe the design and synthesis of a dual-responsive organic/inorganic hybrid microcontainer with two payloads in separate storage spaces that is formed by the rapid UV-initiated polymerization of Pickering emulsions. The stellate mesopore silica nanoparticles with poly(N-isopropylacrylamide) grafted inside the mesopores were loaded with one compound (Nile red) and used as Pickering emulsifiers to stabilize oil-in-water droplets...
February 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28220971/2d-materials-for-optical-modulation-challenges-and-opportunities
#5
REVIEW
Shaoliang Yu, Xiaoqin Wu, Yipei Wang, Xin Guo, Limin Tong
Owing to their atomic layer thickness, strong light-material interaction, high nonlinearity, broadband optical response, fast relaxation, controllable optoelectronic properties, and high compatibility with other photonic structures, 2D materials, including graphene, transition metal dichalcogenides and black phosphorus, have been attracting increasing attention for photonic applications. By tuning the carrier density via electrical or optical means that modifies their physical properties (e.g., Fermi level or nonlinear absorption), optical response of the 2D materials can be instantly changed, making them versatile nanostructures for optical modulation...
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28218275/gate-controlled-conductance-switching-in-dna
#6
Limin Xiang, Julio L Palma, Yueqi Li, Vladimiro Mujica, Mark A Ratner, Nongjian Tao
Extensive evidence has shown that long-range charge transport can occur along double helical DNA, but active control (switching) of single-DNA conductance with an external field has not yet been demonstrated. Here we demonstrate conductance switching in DNA by replacing a DNA base with a redox group. By applying an electrochemical (EC) gate voltage to the molecule, we switch the redox group between the oxidized and reduced states, leading to reversible switching of the DNA conductance between two discrete levels...
February 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28215935/comparative-study-of-l-asparaginase-based-lop-regimen-over-chop-regimen-before-radiotherapy-for-stage-iie-extranodal-nasal-type-nk-t-cell-lymphoma-a-study-of-2-centers
#7
Limin Huang, Bin Yuan, Haixia Wu, Hongliang Chu, Yayun Liu, Shuang Wu, Hong Li, He Lu, Hui Chen
BACKGROUND: In this study we evaluated the efficacy of an L-asparaginase-based LOP (L-asparaginase, vincristine, and dexamethasone) regimen in extranodal Natural Killer (NK)/T-cell lymphoma (ENKTL) patients in the Guizhou province of China. PATIENTS AND METHODS: Forty-eight patients were treated with the LOP (L-asparaginase, vincristine and dexamethasone) regimen chemotherapy (CT) and 32 patients with the CHOP (cyclophosphamide, tetrahydropyanyl adriamycin, vincristine, and prednisone) regimen...
January 10, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28212114/discriminative-feature-representation-an-effective-postprocessing-solution-to-low-dose-ct-imaging
#8
Yang Chen, Jin Liu, Yining Hu, Jian Yang, Luyao Shi, Huazhong Shu, Zhiguo Gui, Gouenou Coatrieux, Limin Luo
This paper proposes a concise and effective approach termed discriminative feature representation (DFR) for low dose computerized tomography (LDCT) image processing, which is currently a challenging problem in medical imaging field. This DFR method assumes LDCT images as the superposition of desirable high dose CT (HDCT) 3D features and undesirable noise-artifact 3D features (the combined term of noise and artifact features induced by low dose scan protocols), and the decomposed HDCT features are used to provide the processed LDCT images with higher quality...
February 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28210258/human-gingiva-derived-mesenchymal-stem-cells-inhibit-xeno-graft-versus-host-disease-via-cd39-cd73-adenosine-and-ido-signals
#9
Feng Huang, Maogen Chen, Weiqian Chen, Jian Gu, Jia Yuan, Yaoqiu Xue, Junlong Dang, Wenru Su, Julie Wang, Homayoun H Zadeh, Xiaoshun He, Limin Rong, Nancy Olsen, Song Guo Zheng
Mesenchymal stem cells have the capacity to maintain immune homeostasis and prevent autoimmunity. We recently reported that human-derived gingival mesenchymal stem cells (GMSCs) have strong capacity to suppress immune responses and T cell-mediated collagen-induced arthritis in animals. However, it is unclear whether these cells can suppress human T cell-mediated diseases. Here, we used a xenogenic GVHD model in the NOD/SCID mouse, which is a useful preclinical construct for evaluating the therapeutic and translational potential of this approach for applications in human disease...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28208253/engineering-carbon-nanotube-fiber-for-real-time-quantification-of-ascorbic-acid-levels-in-a-live-rat-model-of-alzheimer-s-disease
#10
Limin Zhang, Fangling Liu, Xuemei Sun, Guang-Feng Wei, Yang Tian, Zhi-Pan Liu, Rong Huang, Yanyan Yu, Huisheng Peng
Ascorbic acid (AA) levels are closely correlated with physiological and pathological events in brain diseases, but the mechanism remains unclear, mainly due to the difficulty of accurately analyzing AA levels in live brain. In this study, by engineering tunable defects and oxygen-containing species in carbon nanotubes, a novel aligned carbon nanotube fiber was developed as an accurate microsensor for the ratiometric detection of AA levels in live rat brains with Alzheimer's disease (AD). AA oxidation is greatly facilitated on the fiber surface at a low potential, leading to high sensitivity as well as high selectivity against potential sources of interference in the brain...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28207394/weakly-supervised-patchnets-describing-and-aggregating-local-patches-for-scene-recognition
#11
Zhe Wang, Limin Wang, Yali Wang, Bowen Zhang, Yu Qiao
Traditional feature encoding scheme (e.g., Fisher vector) with local descriptors (e.g., SIFT) and recent convolutional neural networks (CNNs) are two classes of successful methods for image recognition. In this paper, we propose a hybrid representation, which leverages the discriminative capacity of CNNs and the simplicity of descriptor encoding schema for image recognition, with a focus on scene recognition. To this end, we make three main contributions from the following aspects. First, we propose a patch-level and end-to-end architecture to model the appearance of local patches, called PatchNet...
February 9, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28202073/distinct-patterns-and-prognostic-values-of-tumor-infiltrating-macrophages-in-hepatocellular-carcinoma-and-gastric-cancer
#12
Jin-Qing Li, Xing-Juan Yu, Yong-Chun Wang, Li-Yun Huang, Chao-Qun Liu, Limin Zheng, Yu-Jing Fang, Jing Xu
BACKGROUND: Macrophages (Mφs) constitute a major component of the leukocyte infiltrate and perform distinct roles in different tumor microenvironments. This study aimed to characterize the distribution, composition and prognostic value of Mφs in hepatocellular carcinoma (HCC) and gastric cancer (GC). METHODS: Immunohistochemistry and immunofluorescence were used to identify Mφ subsets in HCC and GC tissues. Kaplan-Meier analysis and Cox regression models were applied to estimate the overall survival (OS) for HCC and GC patients...
February 15, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28199747/outcomes-in-patients-with-early-stage-breast-cancer-who-underwent-a-21-gene-expression-assay
#13
Carlos H Barcenas, Akshara Raghavendra, Arup K Sinha, Masood Pasha Syed, Limin Hsu, Modesto G Patangan, Mariana Chavez-MacGregor, Yu Shen, Gabriel H Hortobagyi, Vicente Valero, Sharon H Giordano, Naoto T Ueno, Debu Tripathy
BACKGROUND: Invasive disease-free survival (IDFS) rates are excellent in patients with breast cancer (BC) with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), axillary lymph node-negative (LN-) tumors with a 21-gene expression assay recurrence score (RS) of 0 to 10. However, to the authors' knowledge, the outcomes among patients with an RS of 11 to 25 who are treated with endocrine therapy alone are unknown. METHODS: In this retrospective single-institution study, the authors described the characteristics of patients with HR+, HER2-, LN- BC who underwent a 21-gene expression assay...
February 15, 2017: Cancer
https://www.readbyqxmd.com/read/28199743/novel-bi2-wo6-coupled-fe3-o4-magnetic-photocatalysts-preparation-characterization-and-photodegradation-of-tetracycline-hydrochloride
#14
Tianye Wang, Shuang Zhong, Shuang Zou, Fuhuan Jiang, Limin Feng, Xiaosi Su
Novel Bi2 WO6 coupled Fe3 O4 magnetic photocatalysts with excellent and stable photocatalytic activity for degrading tetracycline hydrochloride and RhB were successfully synthesized via a facile solvothermal route. Through the characterization of the as-prepared magnetic photocatalysts by XRD, SEM, TEM, XPS, UV-vis diffuse reflectance spectra, it was found that the as-prepared magnetic photocatalysts were synthesized by the coupling of Bi2 WO6 and Fe3 O4 , and introduction of appropriated Fe3 O4 can improved nanospheres morphology and visible-light response...
February 15, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28194820/self-assembly-of-hierarchical-ni-mo-polydopamine-microflower-and-its-conversion-to-ni-mo2c-composite-for-water-splitting
#15
Lianshan Sun, Chunli Wang, Qujiang Sun, Yong Cheng, Limin Wang
On the purpose to find efficient non-noble metal catalysts for water splitting, hierarchical Ni-Mo-polydopamine microflowers are synthesized through a facile aqueous phase reaction at room temperature. Herein, NiMoO4 nanowires are utilized as Ni and Mo source, meantime, they can complex with dopamine to form hierarchical structure and affect the scale of the final product. And the energy dispersive spectrometer (EDS) measurement of Ni-Mo2C/C microflowers (MF) show a high content of Mo2C and Ni (>90 wt%)...
February 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28194624/concentration-of-heavy-metals-in-vegetables-and-potential-health-risk-assessment-in-china
#16
Taiyang Zhong, Dawei Xue, Limin Zhao, Xiuying Zhang
Food safety is an important issue in the world. This study assessed the health risk for the Chinese public when consuming vegetables grown in China, based on 1335 data records from 220 published papers during 2007-2016. The results showed that the average of Pb, Cd, and Hg concentration in vegetables was 0.106, 0.041, and 0.008 mg/kg, which were lower than the maximum allowable concentrations, respectively. Leaf vegetables contained higher heavy metals than root vegetables and fruit vegetables. On a provincial scale, the highest Pb, Cd, and Hg concentrations in vegetables were determined by those in soil and atmosphere...
February 13, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28187545/two-new-species-of-i-indonemoura-i-plecoptera-nemouridae-from-yunnan-province-of-southwestern-china
#17
Weihai Li, Limin Wu, Ding Yang
Two new species of the nemourid genus Indonemoura are described, Indonemoura curvispina sp. nov. and I. spirocornua sp. nov., from the Gaoligong Mountains of Yunnan Province of southwestern China. The taxonomic relationships with related species are discussed.
February 9, 2017: Zootaxa
https://www.readbyqxmd.com/read/28178130/de-escalation-empirical-antibiotic-therapy-improved-survival-for-patients-with-severe-aplastic-anemia-treated-with-antithymocyte-globulin
#18
Rong Fu, Tong Chen, Jia Song, Guojin Wang, Lijuan Li, Erbao Ruan, Hui Liu, Yihao Wang, Huaquan Wang, Limin Xing, Yuhong Wu, Hong Liu, Wen Qu, Zonghong Shao
We aimed to investigate the efficacy and safety of de-escalation empirical therapy for controlling infection in patients with severe aplastic anaemia (SAA) treated with antithymocyte globulin (ATG). Eighty-seven ATG-treated SAA patients who had microbiological culture-confirmed infections from 2006 to 2015 in our center were retrospectively analyzed. The efficacy of de-escalation and non-de-escalation therapy was compared. Among all 87 patients, 63 patients were treated with de-escalation therapy and 24 patients with non-de-escalation therapy...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28177147/shifting-dementia-discourses-from-deficit-to-active-citizenship
#19
Linda Birt, Fiona Poland, Emese Csipke, Georgina Charlesworth
Within western cultures, portrayals of dementia as 'a living death' are being challenged by people living with the diagnosis. Yet dementia remains one of the most feared conditions. The sociological lens of citizenship provides a conceptual framework for reviewing the role of society and culture in repositioning dementia away from deficit to a discourse of agency and interdependence. Awareness of cognitive change, and engaging with the diagnostic process, moves people into a transitional, or 'liminal' state of uncertainty...
February 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/28176409/missing-life-stories-the-narratives-of-palliative-patients-parents-and-physicians-in-paediatric-oncology
#20
E De Clercq, B S Elger, T Wangmo
Illness narratives have become very popular. The stories of children, however, are rarely ever studied. This paper aims to provide insight into how children, parents and physicians make sense of progressive childhood cancer. It also explores how this meaning-giving process interacts with cultural dominant stories on cancer and dying. The presented data come from 16 open-ended face-to-face interviews with palliative paediatric patients, their parents and physicians. The interviews were carried out in eight paediatric oncology centres in Switzerland...
February 8, 2017: European Journal of Cancer Care
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