Luis Guilherme F Rodrigues, Leonardo D de Araujo, Silvia L R Roa, Ana C Bueno, Ernane T Uchoa, José Antunes-Rodrigues, Ayrton C Moreira, Lucila L K Elias, Margaret de Castro, Clarissa S Martins
Objective: Feeding restriction in rats alters the oscillators in suprachiasmatic, paraventricular, and arcuate nuclei, hypothalamic areas involved in food intake. In the present study, using the same animals and experimental protocol, we aimed to analyze if food restriction could reset clock genes ( Clock, Bmal1 ) and genes involved in lipid metabolism ( Pgc1a, Pparg, Ucp2 ) through nutrient-sensing pathways ( Sirt1, Ampk, Nampt ) in peripheral tissues. Methods: Rats were grouped according to food access: Control group (CG, food ad libitum ), Restricted night-fed (RF-n, food access during 2 h at night), Restricted day-fed (RF-d, food access during 2 h in the daytime), and Day-fed (DF, food access during 12 h in the daytime)...
September 29, 2021: Archives of Endocrinology and Metabolism