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https://www.readbyqxmd.com/read/29790033/biomechanical-properties-of-polymer-infiltrated-ceramic-crowns-on-one-piece-zirconia-implants-after-long-term-chewing-simulation
#1
Pia Baumgart, Holger Kirsten, Rainer Haak, Constanze Olms
BACKGROUND: Implant and superstructure provide a complex system, which has to withstand oral conditions. Concerning the brittleness of many ceramics, fractures are a greatly feared issue. Therefore, polymer-infiltrated ceramic networks (PICNs) were developed. Because of its low Young's modulus and high elastic modulus, the PICN crown on a one-piece zirconia implant might absorb forces to prevent the system from fracturing in order to sustain oral forces. Recommendations for the material of superstructure on zirconia implants are lacking, and only one study investigates PICN crowns on these types of implants...
May 23, 2018: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/29788285/altered-asparagine-and-glutamate-homeostasis-precede-coronary-artery-disease-and-type-2-diabetes
#2
Filip Ottosson, Einar Smith, Olle Melander, Céline Fernandez
Context: Type 2 diabetes (T2DM) is accompanied by an increased risk of coronary artery disease (CAD), but the overlapping metabolic disturbances preceding both diseases are insufficiently described. Objective: We hypothesized that alterations in metabolism occur years before clinical manifestation of T2DM and CAD and that these alterations are reflected in the plasma metabolome. We thus aimed to identify plasma metabolites that predict future T2DM and CAD. Design: Using targeted liquid chromatography-mass spectrometry (LC-MS), 35 plasma metabolites (amino acid metabolites and acylcarnitines) were quantified in 1049 individuals, free from CAD and diabetes, drawn from a population sample of 5386 in the Malmö Preventive Project (mean age 69...
May 16, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29785339/identification-of-potential-crucial-genes-and-pathways-associated-with-vein-graft-restenosis-based-on-gene-expression-analysis-in-experimental-rabbits
#3
Qiang Liu, Xiujie Yin, Mingzhu Li, Li Wan, Liqiao Liu, Xiang Zhong, Zhuoqi Liu, Qun Wang
Occlusive artery disease (CAD) is the leading cause of death worldwide. Bypass graft surgery remains the most prevalently performed treatment for occlusive arterial disease, and veins are the most frequently used conduits for surgical revascularization. However, the clinical efficacy of bypass graft surgery is highly affected by the long-term potency rates of vein grafts, and no optimal treatments are available for the prevention of vein graft restenosis (VGR) at present. Hence, there is an urgent need to improve our understanding of the molecular mechanisms involved in mediating VGR...
2018: PeerJ
https://www.readbyqxmd.com/read/29778671/international-study-of-comparative-health-effectiveness-with-medical-and-invasive-approaches-ischemia-trial-rationale-and-design
#4
David J Maron, Judith S Hochman, Sean M O'Brien, Harmony R Reynolds, William E Boden, Gregg W Stone, Sripal Bangalore, John A Spertus, Daniel B Mark, Karen P Alexander, Leslee Shaw, Jeffrey S Berger, T Bruce Ferguson, David O Williams, Robert A Harrington, Yves Rosenberg
BACKGROUND: Prior trials comparing a strategy of optimal medical therapy with or without revascularization have not shown that revascularization reduces cardiovascular events in patients with stable ischemic heart disease (SIHD). However, those trials only included participants in whom coronary anatomy was known prior to randomization and did not include sufficient numbers of participants with significant ischemia. It remains unknown whether a routine invasive approach offers incremental value over a conservative approach with catheterization reserved for failure of medical therapy in patients with moderate or severe ischemia...
April 21, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29754662/rationale-and-design-of-a-trial-to-personalize-risk-assessment-in-familial-coronary-artery-disease
#5
Thomas H Marwick, Kristyn Whitmore, Stephen J Nicholls, Tony Stanton, Geoffrey Mitchell, Andrew Tonkin, Christopher Blizzard, Amanda Neil, Catherine Jones, Gerald F Watts
BACKGROUND: The lifetime risk of coronary artery disease (CAD) is doubled in people with a family history of premature disease, yet this risk is not captured in most 5- or 10-year risk assessment algorithms. Coronary artery calcium scoring (CCS) is a marker of subclinical CAD risk, which has been shown in observational studies to provide prognostic information that is incremental to clinical assessment; is relatively inexpensive; and is performed with a small radiation dose. However, the use of CCS in guiding prevention is not strongly supported by guidelines...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29752179/the-effect-of-eicosapentaenoic-and-docosahexaenoic-acids-on-physical-function-exercise-and-joint-replacement-in-patients-with-coronary-artery-disease-a-secondary-analysis-of-a-randomized-clinical-trial
#6
Abdulhamied Alfaddagh, Tarec K Elajami, Mohamad Saleh, Mohamad Elajami, Bruce R Bistrian, Francine K Welty
BACKGROUND: Poor physical function impairs fitness and exercise and is associated with worse cardiovascular outcomes and all-cause mortality. Joint pain and stiffness limit physical function. OBJECTIVE: To determine if eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation improves physical function and exercise in coronary artery disease (CAD) patients. METHODS: A total of 291 subjects with stable CAD were randomized to either Lovaza (1...
March 14, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29749982/prevalence-of-multiple-coronary-artery-disease-risk-factors-in-kerman-a-population-based-study-in-southeast-iran
#7
Hamid Najafipour, Mahdi Afshari, Farzaneh Rostamzadeh
Background: The risk of disease with 1 risk factor is increased by the presence of additional risk factors. The goal of this study was to assess the prevalence of multiple coronary artery disease (CAD) risk factors among adults in Kerman, Iran, to identify the population groups most at risk. Methods: The present study included 5900 adults aged between 15 and 75 years in 2011 in Kerman, Iran. They were selected by 1-stage cluster sampling. Blood pressure, fasting blood glucose, lipids, and 6 CAD risk factors were assessed in the study population...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29747917/elective-coronary-revascularization-procedures-in-patients-with-stable-coronary-artery-disease-incidence-determinants-and-outcome-from-the-coronor-study
#8
Martial Hamon, Gilles Lemesle, Thibaud Meurice, Olivier Tricot, Nicolas Lamblin, Christophe Bauters
OBJECTIVES: The authors sought to describe the incidence, determinants, and outcome of elective coronary revascularization (ECR) in patients with stable coronary artery disease (CAD). BACKGROUND: Observational data are lacking regarding the practice of ECR in patients with stable CAD receiving modern secondary prevention. METHODS: The authors analyzed coronary revascularization procedures performed during a 5-year follow-up in 4,094 stable CAD outpatients included in the prospective multicenter CORONOR (Suivi d'une cohorte de patients COROnariens stables en région NORd-Pas-de-Calais) registry...
May 14, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29745255/pannexin-1-channels-on-endothelial-cells-mediate-vascular-inflammation-during-lung-ischemia-reperfusion-injury
#9
Ashish K Sharma, Eric J Charles, Yunge Zhao, Adishesh K Narahari, Pranav K Baderdinni, Miranda E Good, Ulrike M Lorenz, Irving L Kron, Douglas A Bayliss, Kodi S Ravichandran, Brant E Isakson, Victor E Laubach
Ischemia-reperfusion injury (IRI), which involves inflammation, vascular permeability, and edema, remains a major challenge after lung transplantation. Pannexin 1 (Panx1) channels modulate cellular ATP release during inflammation. This study tests the hypothesis that endothelial Panx1 is a key mediator of vascular inflammation and edema after IR and that IRI can be blocked by Panx1 antagonism. A murine hilar ligation model of IRI was utilized whereby left lungs underwent 1 hour of ischemia and 2 hours of reperfusion...
May 10, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29724553/effect-of-metal-opaquer-on-the-final-color-of-3-ceramic-crown-types-on-3-abutment-configurations
#10
Rabia Arif, Burak Yilmaz, Aras Mortazavi, Tuncer B Ozcelik, William M Johnston
STATEMENT OF PROBLEM: The effect of a recently introduced metal opaquer when used to mask the color of a titanium abutment under ceramic crown systems is unknown. PURPOSE: The purpose of this study was to compare the color coordinates of 3 ceramic crown types-characterized monolithic lithium disilicate (LDC) (IPS e.max; Ivoclar Vivadent AG), layered lithium disilicate (LDL) (IPS e.max; Ivoclar Vivadent AG), and layered zirconia (ZL) (H.C. Starck)-on 3 abutment configurations, nonopaqued titanium (Ti), resin opaqued titanium (Op), and zirconia (Zir)...
April 30, 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29713615/lung-nodule-detection-via-deep-reinforcement-learning
#11
Issa Ali, Gregory R Hart, Gowthaman Gunabushanam, Ying Liang, Wazir Muhammad, Bradley Nartowt, Michael Kane, Xiaomei Ma, Jun Deng
Lung cancer is the most common cause of cancer-related death globally. As a preventive measure, the United States Preventive Services Task Force (USPSTF) recommends annual screening of high risk individuals with low-dose computed tomography (CT). The resulting volume of CT scans from millions of people will pose a significant challenge for radiologists to interpret. To fill this gap, computer-aided detection (CAD) algorithms may prove to be the most promising solution. A crucial first step in the analysis of lung cancer screening results using CAD is the detection of pulmonary nodules, which may represent early-stage lung cancer...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29709892/comparing-the-consistency-and-performance-of-various-coronary-heart-disease-prediction-models-for-primary-prevention-using-a-national-representative-cohort-in-taiwan
#12
Kuo-Liong Chien, Hung-Ju Lin, Ta-Chen Su, Yun-Yu Chen, Pei-Chun Chen
BACKGROUND: Predicting future coronary artery disease (CAD) risk by model-based approaches can facilitate identification of high-risk individuals for prevention and management. Therefore, we compared the consistency and performance of various CAD models for primary prevention using 1 external validation dataset from a national representative cohort in Taiwan.Methods and Results:The 10 CAD prediction models were assessed in a validation cohort of 3559 participants (≥35 years old, 53...
April 27, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29700870/the-cost-effectiveness-of-first-trimester-screening-and-early-preventative-use-of-aspirin-in-women-at-high-risk-of-early-onset-pre-eclampsia
#13
Dayne Ortved, T Lee-Ann Hawkins, Jo-Ann Johnson, Jon Hyett, Amy Metcalfe
OBJECTIVE: Pre-eclampsia (PE) remains a leading cause of maternal and fetal morbidity and mortality. A first trimester screening algorithm predicting the risk of early onset PE has been developed and validated. Early prediction coupled with initiation of aspirin at 11 to 13 weeks in women identified as high risk is effective at reducing the prevalence of early onset PE. The aim of this study is to evaluate the cost-effectiveness of this first trimester screening program coupled with early use of low-dose aspirin in women at high risk of developing early onset PE versus current practice...
April 27, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29688214/-extracranial-aneurysms-of-carotid-arteries-in-the-practice-of-a-vascular-surgeon
#14
R N Lar'kov, S S Zagarov, M V Vishniakova, R V Shilov
The present study was aimed at retrospectively analysing the results of examination and open surgical treatment of patients diagnosed with extracranial aneurysms of carotid arteries. PATIENTS AND METHODS: We analysed the results of examination and outcomes of surgical treatment in a total of 11 patients (6 men and 5 women) presenting with an aneurysm of the extracranial portion of the carotid artery and undergoing treatment at the Department of Vascular and CAD Surgery of the Moscow Regional Research Clinical Institute from 2005 to 2016...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29670844/the-eeffect-of-metformin-combined-with-calcium-vitamin-d-3-against-diet-induced-nonalcoholic-fatty-liver-disease
#15
Sara Shojaei Zarghani, Samin Abbaszadeh, Mohammad Alizadeh, Maryam Rameshrad, Alireza Garjani, Hamid Soraya
Purpose: Metformin is one of the most popular drugs tested against nonalcoholic fatty liver disease (NAFLD). The present study aimed to investigate whether calcium-vitamin D3 cosupplementation will intensify the effect of metformin on the prevention of high-fat, high-fructose (HFFr) diet-induced hepatic steatosis. Methods: Male wistar rats (210±16 g) were assigned into the following seven groups: a Control group to receive a standard chow and six HFFr-fed groups to receive diets containing either normal (0...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670746/a-sniff-away-from-death-a-case-of-cocaine-induced-coronary-artery-dissection
#16
Ioannis Merinopoulos, David Bloore, Philip Read
The multiple, deleterious cardiovascular effects of cocaine abuse are well known. Recent data have shown that cocaine abuse in the UK remains high with an upward trend over the last few years and a significant associated mortality/morbidity. Cocaine-induced coronary artery dissection (CAD) is one of the rare totally preventable manifestations of cocaine abuse. With this case report, we aim to contribute to the limited number of cocaine-induced CAD described in literature and increase public awareness in an attempt to reverse the upward trend of cocaine abuse...
October 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29670721/the-importance-of-correct-implants-positioning-and-masticatory-load-direction-on-a-fixed-prosthesis
#17
João-Paulo-Mendes Tribst, Vinicius-Aneas Rodrigues, Amanda-Maria-de Oliveira Dal Piva, Alexandre-Luiz-Souto Borges, Renato-Sussumu Nishioka
Background: Through the biomechanical study of dental implants, it is possible to understand the dissipation effects of masticatory loads in different situations and prevent the longevity of osseointegration. Aims: To evaluate the microstrains generated around external hexagon implants, using axial and non-axial loads in a fixed four-element prosthesis with straight implants and implants inclined at 17°. Material and Methods: Three implants were modeled using CAD software following the manufacturer's measurements...
January 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29655953/risk-factors-predisposing-to-acute-coronary-syndromes-in-young-women-%C3%A2-45-years-of-age
#18
Maciej Bęćkowski, Marek Gierlotka, Mariusz Gąsior, Lech Poloński, Tomasz Zdrojewski, Rafał Dąbrowski, Jarosław Karwowski, Ilona Kowalik, Wojciech Drygas, Hanna Szwed
BACKGROUND: Acute coronary syndromes (ACS) are rare in young women. The purpose of this study was to characterize risk factors (RF) predisposing to ACS in young women and evaluate possible age-related differences. METHODS AND RESULTS: We studied 1941 young women with ACS aged ≤45 years (≤45ACS) from the PL-ACS registry and compared them with two control groups: 4275 women aged 63-64 years with ACS (63-64ACS) from the PL-ACS registry and 1170 young healthy women aged ≤45 years (≤45H) without confirmed coronary artery disease (CAD), from two national, representative, cross-sectional population health surveys, NATPOL 2011 and WOBASZ...
April 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29655952/population-level-incidence-and-outcomes-of-myocardial-infarction-with-non-obstructive-coronary-arteries-minoca-insights-from-the-alberta-contemporary-acute-coronary-syndrome-patients-invasive-treatment-strategies-coapt-study
#19
Kevin R Bainey, Robert C Welsh, Wendimagegn Alemayehu, Cynthia M Westerhout, Dean Traboulsi, Todd Anderson, Neil Brass, Paul W Armstrong, Padma Kaul
BACKGROUND: Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a known clinical conundrum with limited investigation. Using a large population-based cohort, we examined the incidence, demographic profile, use of evidence-based medicines (EBM) and clinical outcomes of MINOCA patients. METHODS: Patients hospitalized with a primary diagnosis of MI who underwent coronary angiography between 01/04/2002 and 31/03/2014 in Alberta, Canada, were included in the study...
April 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29627214/digital-technology-for-performing-a-nasopalatine-and-greater-palatine-nerve-block-with-a-modified-implant-surgical-guide-a-technique-article
#20
Ankur Dahiya, Antoanela Garbacea, Mathew T Kattadiyil, Abdulaziz AlHelal
This article describes a computer-aided design and computer-aided manufacturing (CAD-CAM) technique to perform a precise nerve block of the nasopalatine and greater palatine nerves by using an implant surgical guide. The technique uses additional guide anchor pins planned and positioned for specific anatomic landmarks during guided implant surgical guide planning. A relief modification virtually designed on the intaglio surface of the surgical guide allows for palatal soft tissue distension following administration of local anesthetic...
April 5, 2018: Journal of Prosthetic Dentistry
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