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https://www.readbyqxmd.com/read/29344396/adversity-of-prolonged-extreme-cold-exposure-among-adult-clients-diagnosed-with-coronary-artery-diseases-a-primer-for-recommending-community-health-nursing-intervention
#1
Eladio Martin S Gumabay, Raquel C Ramirez, Judy Mae M Dimaya, Mae M Beltran
Aim: This research study explored the lived experiences of adults diagnosed with Coronary Artery Disease (CAD) when exposed to a prolonged period of extreme cold. Design: This research study utilized descriptive qualitative research design. Methods: Face-to-face interview sessions with audio recording were conducted. There were 30 informants who participated in the study. Descriptive phenomenology with Colaizzi's method of data analysis was used...
January 2018: Nursing Open
https://www.readbyqxmd.com/read/29334161/the-role-of-neurosonology-in-the-diagnosis-and-management-of-patients-with-carotid-artery-disease-a-review
#2
REVIEW
Odysseas Kargiotis, Apostolos Safouris, Georgios Magoufis, Maria Georgala, Andromachi Roussopoulou, Eleftherios Stamboulis, Konstantinos G Moulakakis, Andreas Lazaris, George Geroulakos, Spyros Vasdekis, Georgios Tsivgoulis
Carotid artery disease (CAD) is a common cause of ischemic stroke with high rates of recurrence. Carotid endarterectomy (CEA) or carotid artery stenting (CAS) are highly recommended for the secondary prevention of symptomatic CAD during the first 14 days following the index event of transient ischemic attack or minor stroke. CEA or CAS may also be offered in selected cases with severe asymptomatic stenosis. Herein, we review the utility of neurosonology in the diagnosis and pre-/peri-interventional assessment of CAD patients who undergo carotid revascularization procedures...
January 15, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29325803/coronary-artery-disease-in-athletes-an-adverse-effect-of-intense-exercise
#3
REVIEW
Hélder Dores, Pedro de Araújo Gonçalves, Nuno Cardim, Nuno Neuparth
Regular physical exercise is responsible for various health benefits, and is recommended for primary and secondary cardiovascular (CV) prevention. Despite these recognized benefits, various clinical events can occur in athletes, including acute myocardial infarction and sudden cardiac death (SCD); the main cause of SCD in veteran athletes is coronary artery disease (CAD). The relationship between intense exercise training and CAD is controversial, and a U-shaped association has been hypothesized. If this is the case, screening for subclinical CAD in older athletes may be justified, and various different methodologies have been proposed...
January 8, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29325539/chinese-cervicocephalic-artery-dissection-study-ccads-rationale-and-protocol-for-a-multicenter-prospective-cohort-study
#4
Zhu Zhu, Yuyuan Xu, Yilong Wang, Zhenhua Zhou, Xiang Han, Aihua Liu, Jing Peng, Yi Xu, Luyao Wang
BACKGROUND: Cervicocephalic artery dissection (CAD) is an important etiology of stroke in the youth. Findings from recent studies suggest it a "group of disease entities" with different underlying etiologies, presentations and prognosis, necessitating an integral study including various types of CAD to get a better understanding of this disease. In addition, Chinese patients with CAD are likely to carry different features from their western counterparts, which remains uncertain yet. Chinese Cervicocephalic Artery Dissection Study (CCADS) therefore aims at exploring the epidemiology, risk factors, clinical/radiological features, diagnosis and prognosis of CAD in Chinese patients...
January 11, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29319564/genetics-in-the-prevention-and-management-of-coronary-artery-disease
#5
Robert Roberts
PURPOSE OF REVIEW: The current review is to describe the genetic risk variants that have been discovered predisposing to coronary artery disease (CAD) and how they are utilized to stratify for risk of CAD. RECENT FINDINGS: Over 90 genetic risk variants have been discovered that predispose to risk for CAD. SUMMARY: The total genetic risk burden for CAD is proportional to the number of risk variants inherited and can be combined into a single number referred to as the genetic risk score (GRS)...
January 9, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29304538/catestatin-prevents-macrophage-driven-atherosclerosis-but-not-arterial-injury-induced-neointimal-hyperplasia
#6
Miho Kojima, Nana Ozawa, Yusaku Mori, Yui Takahashi, Kaho Watanabe-Kominato, Remina Shirai, Rena Watanabe, Kengo Sato, Taka-Aki Matsuyama, Hatsue Ishibashi-Ueda, Shinji Koba, Youichi Kobayashi, Tsutomu Hirano, Takuya Watanabe
Catestatin, a catecholamine-release inhibitory peptide, has multiple cardiovascular activities. Conflicting results have been recently reported by increased or decreased plasma levels of catestatin in patients with coronary artery disease (CAD). However, there have been no previous reports regarding the effects of catestatin on arteriosclerosis. This study evaluated the vasoprotective effects of catestatin on human macrophages, human aortic smooth muscle cells (HASMCs) and human umbilical vein endothelial cells (HUVECs) in vitro, and aortic atherosclerosis and wire injury-induced femoral artery neointimal hyperplasia in apolipoprotein E-deficient (ApoE-/-) mice fed with a high-cholesterol diet...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29298434/coiled-coil-formation-conveys-a-stim1-signal-from-er-lumen-to-cytoplasm
#7
Nupura Hirve, Vangipurapu Rajanikanth, Patrick G Hogan, Aparna Gudlur
STIM1 and STIM2 are endoplasmic reticulum (ER) membrane proteins that sense decreases in ER-luminal free Ca2+ and, through a conformational change in the STIM cytoplasmic domain, control gating of the plasma membrane Ca2+ channel ORAI1. To determine how STIM1 conveys a signal from the ER lumen to the cytoplasm, we studied the Ca2+-dependent conformational change of engineered STIM1 proteins in isolated ER membranes and, in parallel, physiological activation of these proteins in cells. We find that conserved "sentinel" features of the CC1 region help to prevent activation while Ca2+ is bound to STIM ER-luminal domains...
January 2, 2018: Cell Reports
https://www.readbyqxmd.com/read/29285453/predisposition-of-angiotensin-converting-enzyme-deletion-deletion-genotype-to-coronary-artery-disease-with-type-2-diabetes-mellitus-in-south-india
#8
Dhivakar Mani, Rathika Chinniah, Padmamalini Ravi, Krishnan Swaminathan, R A Janarthanan, Murali Vijayan, Kamaraj Raju, Balakrishnan Karuppiah
Background: Worldwide, South Asians contribute to a high proportion of coronary artery disease (CAD) burden, mainly attributed to a high prevalence of diabetes. Early identification of such high-risk individuals would enable aggressive disease modification and prevention of complications. Definition of susceptible genotypes early in the course of disease may be one such avenue for reduction in morbidity and mortality from CAD. Aim: Our study was aimed to investigate the insertion/deletion polymorphism of angiotensin-converting enzyme (ACE I/D) gene and susceptibility to CAD in patients with type 2 diabetes mellitus (T2DM) in a South Indian population...
November 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29281605/trends-in-cardiovascular-risk-profiles
#9
REVIEW
Samir Kapadia
Outcomes for patients with coronary artery disease (CAD) have improved in the past 20 years likely due to advances in clinical care such as angiotensin-converting enzyme inhibitors, antiplatelet agents, and reduced time to cardiac cauterization procedures. But how have the risk factors for CAD changed in the past 2 decades? Analysis of nearly 4,000 patients with ST-elevation myocardial infarction (STEMI) at a tertiary care center found that patients presenting with acute STEMI are younger and more obese than in the past...
December 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/29260400/no-modifying-effect-of-nutritional-status-on-statins-therapy-in-relation-to-all-cause-death-in-older-patients-with-coronary-artery-disease
#10
Bao-Tao Huang, Fang-Yang Huang, Xiao-Bo Pu, Tian-Li Xia, Yong Peng, Fei Chen, Yong Yang, Yan-Biao Liao, Mao Chen
BACKGROUND: Statins therapy in the secondary prevention of coronary artery disease (CAD) is associated with a lower risk of adverse cardiovascular events. However, little is known regarding the association of elderly patients with nutritional risk on statin therapy. AIMS: To investigate whether older patients with CAD who were at nutritional risk gain similar survival benefit from statins therapy as their counterparts without nutritional risk. METHODS: We conducted a retrospective hospital-based cohort study among 1705 patients with CAD who were older than 65 years of age, using coronary heart disease database from 2008 to 2012...
December 19, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29258230/anti-atherogenic-activity-of-polyphenol-rich-extract-from-bee-pollen
#11
Anna Rzepecka-Stojko, Jerzy Stojko, Krzysztof Jasik, Ewa Buszman
The aim of this study was to determine the effect of polyphenol-rich ethanol extract of bee pollen (EEP) on atherosclerosis induced by a high-fat diet in ApoE-knockout mice. EEP was given with feed in two doses of 0.1 and 1 g/kg body mass (BM). The studies have been conducted in a period of 16 weeks. The following factors were estimated: total cholesterol (TC), oxidized low density lipoproteins (ox-LDL), asymmetric dimethylarginine (ADMA), angiotensin-converting enzyme (ACE) and angiotensin II (ANG II) in the 5th, 10th, 12th, 14th, and 16th week of the experiment...
December 18, 2017: Nutrients
https://www.readbyqxmd.com/read/29251114/s-allylcysteine-improves-blood-flow-recovery-and-prevents-ischemic-injury-by-augmenting-neovasculogenesis
#12
Jia-Ning Syu, Mei-Due Yang, Shu-Yao Tsai, En-Pei Isabel Chiang, Shao-Chih Chiu, Che-Yi Chao, Raymond L Rodriguez, Feng-Yao Tang
Studies suggest that a low level of circulating human endothelial progenitor cells (EPCs) is a risk factor for ischemic injury and coronary artery disease (CAD). Consumption of S-allylcysteine (SAC) is known to prevent CAD. However, the protective effects of SAC on the ischemic injury are not yet clear. In this study, we examined whether SAC could improve blood flow recovery in ischemic tissues through EPC-mediated neovasculogenesis. The results demonstrate that SAC significantly enhances the neovasculogenesis of EPCs in vitro...
October 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29249427/prevalence-and-management-of-familial-hypercholesterolemia-in-patients-with-coronary-artery-disease-the-heredity-survey
#13
Pompilio Faggiano, Angela Pirillo, Raffaele Griffo, Marco Ambrosetti, Roberto Pedretti, Giampaolo Scorcu, Marika Werren, Oreste Febo, Gabriella Malfatto, Giuseppe Favretto, Filippo Sarullo, Francesco Antonini-Canterin, Gianni Zobbi, Pierluigi Temporelli, Alberico L Catapano
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of low density lipoprotein cholesterol (LDL-C) predisposing to premature cardiovascular disease. Its prevalence varies and has been estimated around 1 in 200-500. The Heredity survey evaluated the prevalence of potential FH and the therapeutic approaches among patients with established coronary artery disease (CAD) or peripheral artery disease (PAD) in which it is less well documented...
February 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29196298/risk-assessment-in-patients-with-diabetes-with-the-timi-risk-score-for-atherothrombotic-disease
#14
Brian A Bergmark, Deepak L Bhatt, Eugene Braunwald, David A Morrow, Ph Gabriel Steg, Yared Gurmu, Avivit Cahn, Ofri Mosenzon, Itamar Raz, Erin Bohula, Benjamin M Scirica
OBJECTIVE: Improved risk assessment for patients with type 2 diabetes and elevated cardiovascular (CV) risk is needed. The TIMI Risk Score for Secondary Prevention (TRS 2°P) predicts a gradient of risk in patients with prior myocardial infarction (MI) but has not been evaluated in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: CV event rates were compared by baseline TRS 2°P in 16,488 patients enrolled in SAVOR-TIMI 53 with type 2 diabetes and high CV risk or established CV disease...
December 1, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29188805/prevention-rivaroxaban-plus-aspirin-in-cad-or-pad
#15
Gregory B Lim
No abstract text is available yet for this article.
November 30, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29174475/temporal-trends-in-the-premorbid-use-of-preventive-treatments-in-patients-with-acute-ischemic-cerebrovascular-events-and-a-history-of-vascular-disease-the-dijon-stroke-registry-1985-2010
#16
Catia Khoumri, Henri Bailly, Benoit Delpont, Benoit Daubail, Christelle Blanc, Cécile Chazalon, Jérôme Durier, Marie Hervieu-Bègue, Guy-Victor Osseby, Olivier Rouaud, Maurice Giroud, Catherine Vergely, Yannick Béjot
INTRODUCTION: Although secondary prevention in patients with arterial vascular diseases has improved, a gap between recommendations and clinical practice may exist. OBJECTIVES: We aimed to evaluate temporal trends in the premorbid use of preventive treatments in patients with ischemic cerebrovascular events (ICVE) and prior vascular disease. METHODS: Patients with acute ICVE (ischemic stroke/TIA) were identified through the population-based stroke registry of Dijon, France (1985-2010)...
November 22, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29167720/peek-polymer-in-orthodontics-a-pilot-study-on-children
#17
Gaetano Ierardo, Valeria Luzzi, Michela Lesti, Iole Vozza, Orlando Brugnoletti, Antonella Polimeni, Maurizio Bossù
The purpose of the study has been making the orthodontic space maintainers in PEEK polymer (Polyetheretherketone) through a digital workflow. New digital technologies are taking hold in diagnosis, therapy and in dental laboratories. The digital world can help dentist in diagnosis and therapy: -diagnosis through the acquisition of radiographic images (CBCT) or scanners which allow the creation of 3D digital models - about therapy thanks to dental CAD CAM system. It consists of design devices through an dedicated software CAD and then realize devices through CAM system...
October 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29167036/inverse-association-between-hyperthymic-affective-temperament-and-coronary-atherosclerosis-a-coronary-computed-tomography-angiography-study
#18
János Nemcsik, Milán Vecsey-Nagy, Bálint Szilveszter, Márton Kolossváry, Júlia Karády, Andrea László, Beáta Kőrösi, Zsófia Nemcsik-Bencze, Xénia Gonda, Béla Merkely, Zoltán Rihmer, Pál Maurovich-Horvat
OBJECTIVE: A bidirectional relationship exists between psychiatric disorders and cardiovascular diseases, however less is known with regards to personality traits. Accumulating data suggest that affective temperaments are both associated with psychiatric and somatic diseases. The aim of our study was to evaluate the associations between different affective temperaments and the presence of coronary atherosclerosis. METHODS: 200 consecutive patients referred to coronary computed tomography angiography (CCTA) due to suspected coronary artery disease (CAD) were included in our study...
December 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29150290/premature-atherosclerosis-in-premenopausal-women-does-cytokine-balance-play-a-role
#19
Jo-Ann Eastwood, Doris A Taylor, B Delia Johnson, Micheline Resende, Barry L Sharaf, Bina Ahmed, Margo Minissian, Chrisandra Shufelt, Noel Bairey Merz
Contributory risk factors to premature coronary artery disease (CAD) in premenopausal women are poorly understood and data on this subset of women is lacking. There is growing evidence that the process of inflammation is a part of the atherosclerotic process. Mechanistic insights from animal work suggest that the profile of circulating cytokines reflects both endothelial integrity and the presence of immune and progenitor cells. Significant differences in pro- and anti-inflammatory cytokine concentrations between patients with and without CAD exist...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29125689/resource-utilization-and-cost-of-influenza-requiring-hospitalization-in-canadian-adults-a-study-from-the-serious-outcomes-surveillance-network-of-the-canadian-immunization-research-network
#20
Carita Ng, Lingyun Ye, Stephen G Noorduyn, Margaret Hux, Edward Thommes, Ron Goeree, Ardith Ambrose, Melissa K Andrew, Todd Hatchette, Guy Boivin, William Bowie, May ElSherif, Karen Green, Jennie Johnstone, Kevin Katz, Jason Leblanc, Mark Loeb, Donna MacKinnon-Cameron, Anne McCarthy, Janet McElhaney, Allison McGeer, Andre Poirier, Jeff Powis, David Richardson, Rohita Sharma, Makeda Semret, Stephanie Smith, Daniel Smyth, Grant Stiver, Sylvie Trottier, Louis Valiquette, Duncan Webster, Shelly A McNeil
BACKGROUND: Consideration of cost determinants is crucial to inform delivery of public vaccination programs. OBJECTIVES: To estimate the average total cost of laboratory-confirmed influenza requiring hospitalization in Canadians prior to, during, and 30 days following discharge. To analyze effects of patient/disease characteristics, treatment, and regional differences in costs. METHODS: Study utilized previously recorded clinical characteristics, resource use, and outcomes of laboratory-confirmed influenza patients admitted to hospitals in the Serious Outcomes Surveillance (SOS), Canadian Immunization Research Network (CIRN), from 2010/11 - 2012/13...
November 10, 2017: Influenza and Other Respiratory Viruses
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