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Extracapsular Squamous Cell Carcinoma

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https://www.readbyqxmd.com/read/29201160/egfr-and-cortactin-markers-for-potential-double-target-therapy-in-oral-squamous-cell-carcinoma
#1
Oliver Bissinger, Andreas Kolk, Enken Drecoll, Melanie Straub, Christina Lutz, Klaus-Dietrich Wolff, Carolin Götz
Survival periods of patients following surgical therapy of oral squamous cell carcinoma (OSCC) have previously been demonstrated to decrease over recent decades. Epidermal growth factor receptor (EGFR) and Cortactin are molecular markers that are important in tumour progression and development, and interact within the EGF pathway. Although EGFR antibody therapy exists, sufficient efforts for increased survival are still lacking due to the present limited response rates. The aim of the present study was to examine the association between EGFR and Cortactin expression on survival rates of OSCC patients and to determine whether EGFR and Cortactin expression levels are associated with advanced tumor sizes and lymphnode-metastases...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29182490/positive-margins-by-oropharyngeal-subsite-in-transoral-robotic-surgery-for-t1-t2-squamous-cell-carcinoma
#2
Michael J Persky, William G Albergotti, Tanya J Rath, Mark W Kubik, Shira Abberbock, Mathew Geltzeiler, Seungwon Kim, Umamaheswar Duvvuri, Robert L Ferris
Objective To compare positive margin rates between the 2 most common subsites of oropharyngeal transoral robotic surgery (TORS), the base of tongue (BOT) and the tonsil, as well as identify preoperative imaging characteristics that predispose toward positive margins. Study Design Case series with chart review. Setting Tertiary care referral center. Subjects and Methods We compared the final and intraoperative positive margin rate between TORS resections for tonsil and BOT oropharyngeal squamous cell carcinoma (OPSCC), as well as the effect of margins on treatment...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29174473/distribution-of-cervical-metastasis-in-tongue-cancer-are-occult-metastases-predictable-a-retrospective-study-of-117-oral-tongue-carcinomas
#3
Paolo Cariati, Almudena Cabello Serrano, Jose Fernandez Solis, Ildefonso Martinez Lara
PURPOSE: The aims of this study were to evaluate the pattern of distribution of cervical metastasis in tongue cancer and to analyze the various therapeutic options available. Moreover, numerous histological features were analyzed to assess the impact of each factor on overall survival. MATERIALS AND METHODS: A retrospective analysis was conducted using the records of patients diagnosed with oral tongue cancer between 2004 and 2010 in the Virgen de las Nieves University Hospital (HUVN)...
October 13, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29160154/staging-neck-dissection-and-transoral-robotic-surgery-treatment-algorithm-in-palatine-tonsil-cancer
#4
Joseph Spellman, Ryan Sload, Paul Kim, Peter Martin, Gabriel Calzada
Objective This study introduces a treatment algorithm based on staging neck dissection to identify patients with palatine tonsil squamous cell carcinoma who can be effectively treated with single-modality transoral robotic surgery while maintaining quality of life. Study Design Retrospective case series. Setting Kaiser Permanente Southern California Medical Group from 2012 to 2017. Subjects and Methods Patients with early-stage (T1/2) palatine tonsil squamous cell carcinoma with clinically and radiographically N0 necks underwent staging neck dissection...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29137426/therapeutic-implications-of-tumor-free-margins-in-head-and-neck-squamous-cell-carcinoma
#5
Clara Backes, Henning Bier, Andreas Knopf
Objectives: The resection status is one of the most important prognostic factors for patients with head and neck squamous cell carcinoma (HNSCC) concerning overall survival (OS) and recurrence free interval (RFI). To assess whether therapy concepts changed depending on different resection margins and extracapsular extension, OS and RFI data were set into clinical context. Methods: All HNSCC patients who underwent head and neck surgery with/without adjuvant therapy (n=534) were selected over a ten-year period (2001-2011)...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29103752/extracapsular-extension-is-associated-with-worse-distant-control-and-progression-free-survival-in-patients-with-lymph-node-positive-human-papillomavirus-related-oropharyngeal-carcinoma
#6
Jeffrey Shevach, Adam Bossert, Richard L Bakst, Jerry Liu, Krzysztof Misiukiewicz, Jessica Beyda, Brett A Miles, Eric Genden, Marshall R Posner, Vishal Gupta
OBJECTIVES: To determine the prognostic utility of pathologic extracapsular extension (ECE) in human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC). MATERIALS AND METHODS: Retrospective analysis was performed on patients who underwent surgery for primary HPV-related OPSCC and received adjuvant radiotherapy (RT) between 2006 and 2015. Locoregional control (LRC), distant control (DC), progression-free survival (PFS) and overall survival (OS) were compared between the groups with and without ECE using univariate Kaplan-Meier and multivariate Cox regression survival analyses...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29023924/decreased-peritumoral-cd1a-cells-predicts-worse-prognosis-in-oral-squamous-cell-carcinoma
#7
Juscelino Freitas Jardim, Rogério Gondak, Marisol Miranda Galvis, Clovis Antonio Lopes Pinto, Luiz Paulo Kowalski
BACKGROUND: Dendritic cells (DCs) are known to play a central role in the regulation of both innate and adaptive immunologic responses, including antitumor immunity. This study aimed to evaluate the prognostic impact of intra and peritumoral dendritic cells in oral squamous cell carcinoma (OSCC) affecting tongue and floor of the mouth. PATIENTS AND METHODS: Immunohistochemical reactions for CD1a and CD83 were performed in 53 patients with OSCC in tongue and floor of the mouth...
October 11, 2017: Histopathology
https://www.readbyqxmd.com/read/28986696/progression-level-of-extracapsular-spread-and-tumor-budding-for-cervical-lymph-node-metastasis-of-oscc
#8
Shin-Ichi Yamada, Mitsunobu Otsuru, Souichi Yanamoto, Takumi Hasegawa, Hitoshi Aizawa, Takahiro Kamata, Nobuhiro Yamakawa, Tomoyuki Kohgo, Akira Ito, Yuri Noda, Chihoko Hirai, Tetsuya Kitamura, Masaya Okura, Tadaaki Kirita, Michihiro Ueda, Tetsuro Yamashita, Yoshihide Ota, Takahide Komori, Masahiro Umeda, Hiroshi Kurita
OBJECTIVES: The progression level of extracapsular spread (ECS) for cervical lymph node metastasis of oral squamous cell carcinoma (OSCC) was previously divided into three types, and their relationships with the prognosis of patients were re-examined. PATIENTS AND METHODS: The Kaplan-Meier method was used to examine overall survival (OS) and relapse-free survival (RFS) curves. Prognosis factor for recurrence was analyzed with univariate and multivariate analysis...
October 6, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28913316/metastatic-squamous-cell-carcinoma-of-the-lower-lip-analysis-of-the-5-year-survival-rate
#9
Tommaso Agostini, Giuseppe Spinelli, Francesco Arcuri, Raffaella Perello
OBJECTIVES: The author analyse the impact of extracapsular lymph node spread and bone engagement in the ipsilateral neck of patients suffering squamous cell carcinoma (SCC) of the lower lip. METHODS: The data of 56 neck dissections performed in patients suffering SCC of the lower lip between January 2000 and December 2008 were retrospectively analysed. Statistical analysis was performed with the Kaplan-Meier life table method, and the survival rate was investigated with the log rank statistic and significance test...
June 2017: Archives of Craniofacial Surgery
https://www.readbyqxmd.com/read/28894823/the-benefit-of-adjuvant-radiation-in-surgically-treated-t1-2-n1-oropharyngeal-squamous-cell-carcinoma
#10
Marcus M Monroe, Luke O Buchmann, Jason P Hunt, Ying J Hitchcock, Shane Lloyd, Mia Hashibe
IMPORTANCE: The benefit of adjuvant radiation in surgically treated T1-2N1 oropharyngeal cancer without adverse pathologic features remains unclear. OBJECTIVES: To compare population-level survival outcomes in surgically-treated T1-2N1 oropharyngeal squamous cell carcinoma (OPSCC) with and without the use of adjuvant radiation. STUDY DESIGN: Retrospective population-based study using the Surveillance, Epidemiology, and End Results (SEER) registry data from 1998-2011...
April 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28864046/-radiotherapy-for-head-and-neck-squamous-cell-carcinoma-state-of-the-art-and-future-directions
#11
REVIEW
U Schick, F Huguet, Y Pointreau, O Pradier
Therapeutic principles of radiation therapy in head and neck carcinomas will be discussed in this review. Intensity-modulated radiotherapy with concomitant cisplatin should be standard. In case of contraindication to chemotherapy, cetuximab is an option, while hyperfractionation should be considered in patients unfit for concomitant treatment. Concomitant chemotherapy should be administered in the presence of extracapsular extensions and positive margins in the postoperative setting. Current research areas such as desescalation in human papillomavirus-positive tumours, adaptive radiotherapy, radiomics and immunotherapy will also be addressed...
October 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28833217/adjuvant-chemoradiation-does-not-improve-survival-in-elderly-patients-with-high-risk-resected-head-and-neck-cancer
#12
Nicholas J Giacalone, Muhammad M Qureshi, Kimberley S Mak, Diana Kirke, Sagar A Patel, Bhartesh A Shah, Andrew R Salama, Scharukh Jalisi, Minh Tam Truong
OBJECTIVES/HYPOTHESIS: Randomized trials have demonstrated that adjuvant chemoradiotherapy (CRT) confers an overall survival (OS) benefit over adjuvant radiation therapy (RT) alone in patients with resected head and neck squamous cell carcinoma (HNSCC) with adverse pathologic features (positive surgical margins [SM+] and/or extracapsular extension [ECE]). Whether this OS benefit exists in an elderly population remains unknown. STUDY DESIGN: Retrospective database study...
August 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28797461/the-importance-of-log-odds-of-positive-lymph-nodes-for-locoregional-recurrence-in-oral-squamous-cell-carcinoma
#13
Ali-Farid Safi, Martin Kauke, Andrea Grandoch, Hans-Joachim Nickenig, Uta Drebber, Joachim Zöller, Matthias Kreppel
OBJECTIVES: Log odds of positive lymph nodes (LODDS) has been demonstrated as a very promising staging model for multiple cancer sites, as it avoids singularity and predicts prognosis significantly better than conventional nodal staging and lymph node ratio. However, published studies on the influence of LODDS for patients with OSCC are very seldom. MATERIAL AND METHODS: Retrospective chart review of 499 patients with treatment-naive oral squamous cell carcinoma...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28755705/systemic-treatment-for-squamous-cell-carcinoma-of-the-head-and-neck
#14
REVIEW
Aditya V Shetty, Deborah J Wong
In patients with locally advanced squamous cell cancer of the head and neck, a multimodality treatment approach is recommended. The addition of platinum-based systemic therapy concurrently with radiation has been shown to be superior to radiation alone and is considered standard therapy for locally advanced disease. No study has shown superiority of induction therapy followed by chemoradiotherapy versus chemoradiotherapy alone. In the adjuvant setting only patients with nodal extracapsular extension or positive margins seem to benefit from chemoradiotherapy versus radiotherapy alone...
August 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28751709/lymph-node-ratio-is-associated-with-adverse-clinicopathological-features-and-is-a-crucial-nodal-parameter-for-oral-and-oropharyngeal-cancer
#15
Zhien Feng, Qiao Shi Xu, Chong Wang, Jin Zhong Li, Ming Hui Mao, Hua Li, Li Zheng Qin, Zhengxue Han
The lymph node ratio(LNR) has been described as a novel predictor of the survival of patients with oral and oropharyngeal squamous cell carcinoma(O/OPSCC). The purpose of this study was to evaluate whether LNR is better at predicting survival and the need for adjuvant treatment than traditional tumour-nodal-metastasis(TNM) staging. Eight hundred nine patients with O/OPSCC and positive lymph node disease were retrospectively enrolled in this study. LNR equal to 0.075 is the best cut-off value for stratifying 5-year disease-free survival(DFS)...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747140/mitochondrial-assembly-receptor-expression-is-an-independent-prognosticator-for-patients-with-oral-tongue-squamous-cell-carcinoma
#16
Yan-Ye Su, Chang-Han Chen, Chih-Yen Chien, Wei-Che Lin, Wan-Ting Huang, Shau-Hsuan Li
INTRODUCTION: Recent evidence suggests that the local renin-angiotensin system has been implicated in various malignancies. The mitochondrial assembly receptor is a newly identified receptor for angiotensin peptides, angiotensin-(1-7), and has an important role in the renin-angiotensin system. However, the role of the mitochondrial assembly receptor in the prognosis of cancer patients remains unclear. The aim of this study was to evaluate the significance of mitochondrial assembly receptor signaling in the prognosis of oral tongue squamous cell carcinoma...
July 2017: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/28742714/impact-of-extracapsular-lymph-node-involvement-after-neoadjuvant-chemoradiation-therapy-followed-by-surgery-in-carcinoma-of-the-esophagus-a-multicenter-study
#17
Lieven P Depypere, Johnny Moons, Christophe Mariette, Xavier B D'Journo, Pascal A Thomas, Arnulf H Hölscher, Elfriede Bollschweiler, Mark I van Berge-Henegouwen, Jan J B Van Lanschot, Toni E M R Lerut, Philippe R Nafteux
OBJECTIVES: The current study aims to examine the impact of extracapsular lymph node involvement (EC-LNI) on survival for both esophageal adenocarcinoma (AC) and squamous cell carcinoma (SCC) treated with neoadjuvant chemoradiation therapy (nCRT) followed by surgery. BACKGROUND: Studies have demonstrated the negative prognostic value of EC-LNI in primary surgery, but its impact after nCRT remains unclear. METHODS: From the databases of 6 European high-volume centers 1505 patients with R0 resections were withheld...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28738193/degree-of-keratinization-is-an-independent-prognostic-factor-in-oral-squamous-cell-carcinoma
#18
Susanne Wolfer, Stefan Elstner, Stefan Schultze-Mosgau
PURPOSE: Keratinization is a routinely reported histologic feature in head and neck cancer. In contrast to numerous clinicopathologic parameters, the prognostic value of keratinization in oral squamous cell carcinoma (OSCC) is rarely reported in the literature. The purpose of this study was to review the outcome of patients with OSCC with a special focus on the degree of keratinization. PATIENTS AND METHODS: In this retrospective cohort study, we evaluated the medical records at the Department of Oral and Maxillofacial Surgery, Jena University Hospital, and investigated the outcome of patients with OSCC with disease-free survival and disease-specific survival according to the degree of keratinization...
June 30, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28721881/final-report-of-a-prospective-randomized-trial-to-evaluate-the-dose-response-relationship-for-postoperative-radiation-therapy-and-pathologic-risk-groups-in-patients-with-head-and-neck%C3%A2-cancer
#19
RANDOMIZED CONTROLLED TRIAL
David I Rosenthal, Abdallah S R Mohamed, Adam S Garden, William H Morrison, Adel K El-Naggar, Mona Kamal, Randal S Weber, Clifton D Fuller, Lester J Peters
PURPOSE: To present the long-term and final report of a phase 3 trial designed to assess dose-response relationship for postoperative radiation therapy (PORT) and pathologic risk groups in head and neck cancer. METHODS AND MATERIALS: Patients who underwent primary surgery for American Joint Committee on Cancer stage III or IV squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx and who required PORT were eligible. Patients' primary sites and involved necks were independently assigned to higher- or lower-risk categories based on a cumulative point score representing increasing risk of recurrence...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28714274/the-relevance-of-the-lymph-node-ratio-as-predictor-of-prognosis-is-higher-in-hpv-negative-than-in-hpv-positive-oropharyngeal-squamous-cell-carcinoma
#20
M F Meyer, J Meinrath, J Seehawer, A Lechner, M Odenthal, A Quaas, R Semrau, C U Huebbers, S Marnitz, R Büttner, D Beutner
OBJECTIVES: Lymph node ratio (LNR) is an established predictor in different entities of carcinoma, including head and neck malignancies. In oropharyngeal squamous cell carcinoma (OPSCC), lymph node involvement differs between human papilloma virus (HPV)-positive and HPV-negative tumours. Herein, we evaluate the impact of HPV association on the concept of LNR. METHODS: 88 surgically treated patients were included in this retrospective chart review. HPV-positive and HPV-negative OPSCC were evaluated for prediction of outcome by LNR separately...
July 17, 2017: Clinical Otolaryngology
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