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Extracapsular Squamous Cell Carcinoma

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https://www.readbyqxmd.com/read/29872911/can-mr-textural-analysis-improve-the-prediction-of-extracapsular-nodal-spread-in-patients-with-oral-cavity-cancer
#1
Russell Frood, Ebrahim Palkhi, Mark Barnfield, Robin Prestwich, Sriram Vaidyanathan, Andrew Scarsbrook
OBJECTIVE: To explore the utility of MR texture analysis (MRTA) for detection of nodal extracapsular spread (ECS) in oral cavity squamous cell carcinoma (SCC). METHODS: 115 patients with oral cavity SCC treated with surgery and adjuvant (chemo)radiotherapy were identified retrospectively. First-order texture parameters (entropy, skewness and kurtosis) were extracted from tumour and nodal regions of interest (ROIs) using proprietary software (TexRAD). Nodal MR features associated with ECS (flare sign, irregular capsular contour; local infiltration; nodal necrosis) were reviewed and agreed in consensus by two experienced radiologists...
June 5, 2018: European Radiology
https://www.readbyqxmd.com/read/29862295/a-predictive-model-to-determine-the-pattern-of-nodal-metastasis-in-oral-squamous-cell-carcinoma
#2
B S M S Siriwardena, I K Rambukewela, T N Pitakotuwage, M N G P K Udagama, P V R Kumarasiri, W M Tilakaratne
Background: Developing histological prediction models that estimate the probability of developing metastatic deposit will help clinicians to identify individuals who need either radical or prophylactic neck dissection, which leads to better prognosis. Identification of accurate predictive models in oral cancer is important to overcome extensive prophylactic surgical management for neck nodes. Therefore, accurate prediction of metastasis in oral cancer would have an immediate clinical impact, especially to avoid unnecessary radical treatment of patients who are at a low risk of metastasis...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29759299/behavior-of-squamous-cell-carcinoma-of-the-floor-of-the-mouth-is-supraomohyoid-neck-dissection-sufficiently-safe-to-manage-clinically-n0-patients
#3
Paolo Cariati, Almudena Cabello Serrano, Maria Roman Ramos, Dario Sanchez Lopez, Jose Fernandez Solis, Ildefonso Martinez Lara
AIM: The main aim of the present report is to study the behavior of SCC of the floor of the mouth. MATERIALS AND METHOD: A retrospective analysis was conducted using the records of patients diagnosed with squamous cell carcinoma of the floor of the mouth between 2000 and 2012 in the HUVN. Ninety-three patients with squamous cell carcinoma of the floor of the mouth treated with tumourectomy and selective neck dissection were included in the study. The pattern of distribution of cervical metastases and numerous histological features such as T-stage, N stage, surgical margins, tumor thickness, ECS (extracapsular spread) and vascular invasion were analyzed...
May 11, 2018: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/29741773/phase-2-trial-of-neoadjuvant-chemotherapy-and-transoral-endoscopic-surgery-with-risk-adapted-adjuvant-therapy-for-squamous-cell-carcinoma-of-the-head-and-neck
#4
Jared M Weiss, Juneko E Grilley-Olson, Allison Mary Deal, Jose P Zevallos, Bhishamjit S Chera, Jennifer Paul, Mary Fleming Knowles, Dmitriy Usenko, Mark C Weissler, Samip Patel, David N Hayes, Trevor Hackman
BACKGROUND: The objective of this study was to demonstrate the feasibility and efficacy of induction chemotherapy, surgery, and pathology-guided adjuvant therapy to treat transorally resectable squamous head and neck cancer. METHODS: Patients had squamous head and neck cancer that was resectable by the transoral route and advanced-stage disease (American Joint Committee on Cancer stage III-IV, T3-T4 tumors, and/or positive lymph nodes). They received treatment with weekly carboplatin at an area under the curve of 2, plus paclitaxel 135 mg/m2 , and daily lapatinib 1000mg for 6 weeks followed by surgical resection...
May 9, 2018: Cancer
https://www.readbyqxmd.com/read/29737907/independent-predictors-of-prognosis-based-on-oral-cavity-squamous-cell-carcinoma-surgical-margins
#5
Marisa R Buchakjian, Timothy Ginader, Kendall K Tasche, Nitin A Pagedar, Brian J Smith, Steven M Sperry
Objective To conduct a multivariate analysis of a large cohort of oral cavity squamous cell carcinoma (OCSCC) cases for independent predictors of local recurrence (LR) and overall survival (OS), with emphasis on the relationship between (1) prognosis and (2) main specimen permanent margins and intraoperative tumor bed frozen margins. Study Design Retrospective cohort study. Setting Tertiary academic head and neck cancer program. Subjects and Methods This study included 426 patients treated with OCSCC resection between 2005 and 2014 at University of Iowa Hospitals and Clinics...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29734474/comparison-of-tumor-volume-thickness-and-t-classification-as-predictors-of-outcomes-in-surgically-treated-squamous-cell-carcinoma-of-the-oral-tongue
#6
Manish Mair, Deepa Nair, Sudhir Nair, Akshat Malik, Aseem Mishra, Sadhana Kannan, Saurabh Bobdey, Hitesh Singhvi, Pankaj Chaturvedi
BACKGROUND: As per TNM classification, superficial tumors with a favorable prognosis are fallaciously clubbed together with unfavorable, deeply infiltrating lesions in the same classification. METHODS: This is a retrospective study of 588 patients with treatment-naive oral tongue cancers. Binary logistic regression was used to identify predictors of nodal metastasis and extracapsular spread (ECS) using tumor volume and thickness as separate models. The C-index was generated to quantify predictive accuracy of T classification, thickness, and tumor volume for survival...
May 7, 2018: Head & Neck
https://www.readbyqxmd.com/read/29610456/potential-of-quantitative-sept9-and-shox2-methylation-in-plasmatic-circulating-cell-free-dna-as-auxiliary-staging-parameter-in-colorectal-cancer-a-prospective-observational-cohort-study
#7
Julia Bergheim, Alexander Semaan, Heidrun Gevensleben, Susanne Groening, Andreas Knoblich, Jörn Dietrich, Julia Weber, Jörg C Kalff, Friedrich Bootz, Glen Kristiansen, Dimo Dietrich
BACKGROUND: Septin 9 (SEPT9) and short stature homeobox 2 (SHOX2) methylation in circulating cell-free DNA (ccfDNA) are powerful biomarkers for colorectal cancer (CRC) screening, as well as head and neck squamous cell carcinoma staging and monitoring. In the present study, we investigated SEPT9 and SHOX2 ccfDNA methylation as auxiliary pre and post-therapeutic staging parameters in CRC patients. METHODS: ccfDNA methylation was quantified in 184 prospectively enrolled patients prior to and 3-10 days after surgery, and biomarker levels were associated with clinico-pathological parameters...
May 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29600236/squamous-cell-carcinoma-of-buccal-mucosa-an-analysis-of-prognostic-factors
#8
Saurabh Bobdey, Jignasa Sathwara, Aanchal Jain, Sushma Saoba, Ganesh Balasubramaniam
Introduction: Carcinoma of the buccal mucosa is the most common oral cavity cancer in the Indian subcontinent. The aim of this study was to analyze the outcome and evaluate prognostic factors in surgically treated buccal mucosa squamous cell carcinoma (BMSCC) patients. Materials and Methods: A retrospective study was performed by reviewing the medical records of 409 pathologically proven buccal mucosa cancer patients, who were diagnosed and surgically treated in Tata Memorial Hospital between January 1, 2006, and December 31, 2008...
January 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29496057/effect-of-adjuvant-radiotherapy-treatment-center-volume-on-overall-survival
#9
Ramez Philips, Daniel Martin, Antoine Eskander, Jeffrey Schord, Nicole Brown, Songzhu Zhao, Guy Brock, Bhavna Kumar, Ricardo Carrau, Enver Ozer, Amit Agrawal, Stephen Y Kang, James W Rocco, David Schuller, Syed Ali, Dukagjin Blakaj, Aashish Bhatt, John Grecula, Theodoros Teknos, Virginia Diavolitsis, Matthew Old
OBJECTIVES: to examine the impact of radiotherapy center volume on overall survival in patients with oral cavity and oropharyngeal squamous cell carcinoma getting adjuvant radiation therapy after receiving surgery at a high-volume center. MATERIALS AND METHODS: a retrospective study was conducted on patients with oral cavity squamous cell carcinoma or oropharyngeal squamous cell carcinoma treated surgically at a tertiary institution from 2000 to 2012 who received adjuvant radiotherapy...
March 2018: Oral Oncology
https://www.readbyqxmd.com/read/29491058/squamous-cell-carcinoma-antigen-encoding-genes-serpinb3-b4-as-potentially-useful-markers-for-the-stratification-of-hnscc-tumours
#10
Zuzana Saidak, Mony Chenda Morisse, Denis Chatelain, Chloé Sauzay, Aline Houessinon, Nelly Guilain, Marion Soyez, Bruno Chauffert, Stéphanie Dakpé, Antoine Galmiche
BACKGROUND/AIM: The squamous cell carcinoma antigen (SCCA), encoded by the genes SERPINB3/B4, is a tumour marker produced by head and neck squamous cell carcinoma (HNSCC). We aimed to examine SERPINB3/B4 mRNA levels and its clinical significance in the therapeutic context. MATERIALS AND METHODS: We retrieved mRNA expression levels, clinical, pathological and genomic data for 520 HNSCC from The Cancer Genome Atlas (TCGA). RESULTS: HNSCC tumours express high levels of SERPINB3/B4 mRNA...
March 2018: Anticancer Research
https://www.readbyqxmd.com/read/29451961/patterns-of-care-and-outcomes-of-adjuvant-therapy-for-high-risk-head-and-neck-cancer-after-surgery
#11
Virginia Wedell Osborn, Babak Givi, Justin Rineer, Dylan Roden, Niki Sheth, Ariel Lederman, Evangelia Katsoulakis, Kenneth Hu, David Schreiber
BACKGROUND: Postoperative chemoradiotherapy (CRT) is considered standard of care in patients with locally advanced head and neck cancer with positive margins and/or extracapsular extension (ECE). METHODS: The National Cancer Data Base (NCDB) was queried to identify patients with squamous cell carcinoma of the head and neck with stages III to IVB disease or with positive margins and/or ECE diagnosed between 2004 and 2012 receiving postoperative radiotherapy (RT)...
June 2018: Head & Neck
https://www.readbyqxmd.com/read/29373201/small-size-of-metastatic-lymph-nodes-with-extracapsular-spread-greatly-impacts-treatment-outcomes-in-oral-squamous-cell-carcinoma-patients
#12
C Michikawa, T Izumo, J Sumino, T Morita, Y Ohyama, Y Michi, N Uzawa
Extracapsular spread (ECS) of metastatic lymph nodes from oral carcinoma is the most significant prognostic predictor of a poor treatment outcome. However, only a few reports on prognostic factors in ECS-positive cases have been investigated. To address this problem, a detailed examination of ECS pathology was conducted to determine the prognostic factors of oral squamous cell carcinoma (OSCC) with ECS of metastatic lymph nodes. This study involved 63 OSCC patients with at least one pathologically metastatic node with ECS...
January 17, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29362124/postoperative-staging-of-the-neck-dissection-using-extracapsular-spread-and-lymph-node-ratio-as-prognostic-factors-in-hpv-negative-head-and-neck-squamous-cell-carcinoma-patients
#13
Katarina Majercakova, Cristina Valero, Montserrat López, Jacinto García, Nuria Farré, Miquel Quer, Xavier León
OBJECTIVES: The presence of nodes with extracapsular spread (ECS) and the lymph node ratio (LNR) have prognostic competence in the pathologic evaluation of patients with a head and neck squamous cell carcinoma (HNSCC) treated with a neck dissection. The purpose of this study is to assess the effect of ECS & LNR on prognosis of HPV negative HNSCC patients treated with neck dissection and to compare to 8th edition TNM/AJCC classification. MATERIALS AND METHODS: We carried out a retrospective study of 1383 patients with HNSCC treated with a neck dissection between 1985 and 2013...
February 2018: Oral Oncology
https://www.readbyqxmd.com/read/29360262/immunocompromised-patients-with-metastatic-cutaneous-nodal-squamous-cell-carcinoma-of-the-head-and-neck-poor-outcome-unrelated-to-the-index-lesion
#14
Johnson K S Lam, Puma Sundaresan, Val Gebski, Michael J Veness
BACKGROUND: Immunocompromised patients with metastatic cutaneous nodal head and neck squamous cell carcinoma (HNSCC) have worse outcomes compared to the immunocompetent. The purpose of this study was to investigate the characteristics of the primary cutaneous squamous cell carcinoma (SCC), nodal pathology, and outcome between these 2 groups. METHODS: Analysis of a prospective database was performed. A 2:1 pooled analysis selected 46 immunocompetent patients matched with 23 immunocompromised patients...
May 2018: Head & Neck
https://www.readbyqxmd.com/read/29313973/mouse-model-of-postsurgical-primary-tumor-recurrence-and-regional-lymph-node-metastasis-progression-in-hpv-related-head-and-neck-cancer
#15
Maxime Mermod, Agnès Hiou-Feige, Esther Bovay, Vincent Roh, Jana Sponarova, Massimo Bongiovanni, Daniel W Vermeer, John H Lee, Tatiana V Petrova, Jean-Paul Rivals, Yan Monnier, Genrich V Tolstonog, Christian Simon
HPV-positive head and neck squamous cell carcinoma (HNSCC) is increasingly frequent. Management is particularly debated in the case of postsurgical high-risk features, that is, positive surgical margins and extracapsular spread (ECS). In this increasingly complex emerging framework of HNSCC treatment, representative preclinical models are needed to support future clinical trials and advances in personalized medicine. Here, we present an immunocompetent mouse model based on the implantation of mouse tonsil epithelial HPV16-E6/E7-expressing cancer cells into the submental region of the floor-of-the-mouth...
June 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29310489/unknown-primary-squamous-cell-carcinoma-of-the-head-and-neck-retrospective-analysis-of-80-cases
#16
Masanobu Mizuta, Morimasa Kitamura, Ichiro Tateya, Hisanobu Tamaki, Shinzo Tanaka, Ryo Asato, Shogo Shinohara, Shinji Takebayashi, Toshiki Maetani, Yoshiharu Kitani, Yohei Kumabe, Tsuyoshi Kojima, Koji Ushiro, Kazuyuki Ichimaru, Keigo Honda, Koichiro Yamada, Koichi Omori
OBJECTIVES: The management of patients with cervical metastasis in head and neck cancer of unknown primary (HNCUP) remains controversial. This current multicenter retrospective study investigated the treatment outcomes of patients with HNCUP. METHODS: The study included patients who were treated curatively at 12 institutions in Japan from January 2006 to December 2015. RESULTS: Eighty patients with HNCUP were included. The median follow-up period was 34 months...
June 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29201160/egfr-and-cortactin-markers-for-potential-double-target-therapy-in-oral-squamous-cell-carcinoma
#17
Oliver Bissinger, Andreas Kolk, Enken Drecoll, Melanie Straub, Christina Lutz, Klaus-Dietrich Wolff, Carolin Götz
Survival periods of patients following surgical therapy of oral squamous cell carcinoma (OSCC) have previously been demonstrated to decrease over recent decades. Epidermal growth factor receptor (EGFR) and Cortactin are molecular markers that are important in tumour progression and development, and interact within the EGF pathway. Although EGFR antibody therapy exists, sufficient efforts for increased survival are still lacking due to the present limited response rates. The aim of the present study was to examine the association between EGFR and Cortactin expression on survival rates of OSCC patients and to determine whether EGFR and Cortactin expression levels are associated with advanced tumor sizes and lymphnode-metastases...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29182490/positive-margins-by-oropharyngeal-subsite-in-transoral-robotic-surgery-for-t1-t2-squamous-cell-carcinoma
#18
Michael J Persky, William G Albergotti, Tanya J Rath, Mark W Kubik, Shira Abberbock, Mathew Geltzeiler, Seungwon Kim, Umamaheswar Duvvuri, Robert L Ferris
Objective To compare positive margin rates between the 2 most common subsites of oropharyngeal transoral robotic surgery (TORS), the base of tongue (BOT) and the tonsil, as well as identify preoperative imaging characteristics that predispose toward positive margins. Study Design Case series with chart review. Setting Tertiary care referral center. Subjects and Methods We compared the final and intraoperative positive margin rate between TORS resections for tonsil and BOT oropharyngeal squamous cell carcinoma (OPSCC), as well as the effect of margins on treatment...
April 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29174473/distribution-of-cervical-metastasis-in-tongue-cancer-are-occult-metastases-predictable-a-retrospective-study-of-117-oral-tongue-carcinomas
#19
Paolo Cariati, Almudena Cabello Serrano, Jose Fernandez Solis, Ildefonso Martinez Lara
PURPOSE: The aims of this study were to evaluate the pattern of distribution of cervical metastasis in tongue cancer and to analyze the various therapeutic options available. Moreover, numerous histological features were analyzed to assess the impact of each factor on overall survival. MATERIALS AND METHODS: A retrospective analysis was conducted using the records of patients diagnosed with oral tongue cancer between 2004 and 2010 in the Virgen de las Nieves University Hospital (HUVN)...
January 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29160154/staging-neck-dissection-and-transoral-robotic-surgery-treatment-algorithm-in-palatine-tonsil-cancer
#20
Joseph Spellman, Ryan Sload, Paul Kim, Peter Martin, Gabriel Calzada
Objective This study introduces a treatment algorithm based on staging neck dissection to identify patients with palatine tonsil squamous cell carcinoma who can be effectively treated with single-modality transoral robotic surgery while maintaining quality of life. Study Design Retrospective case series. Setting Kaiser Permanente Southern California Medical Group from 2012 to 2017. Subjects and Methods Patients with early-stage (T1/2) palatine tonsil squamous cell carcinoma with clinically and radiographically N0 necks underwent staging neck dissection...
March 2018: Otolaryngology—Head and Neck Surgery
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