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ECS squamous cell carcinoma

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https://www.readbyqxmd.com/read/27905110/distinct-molecular-landscapes-between-endometrioid-and-non-endometrioid-uterine-carcinomas
#1
Nathaniel L Jones, Joanne Xiu, Sudeshna Chatterjee-Paer, Alexandre Buckley de Meritens, William M Burke, Ana I Tergas, Jason D Wright, June Y Hou
Endometrial carcinoma (EC) is traditionally characterized as endometrioid and non-endometrioid based on histo-pathologic phenotypes. Molecular-based classifications have been proposed, but are not widely implemented. Herein we examine molecular profiles between EC histologic subtypes. 3133 ECs were submitted between March 2011 and July 2014: 1634 Type I and 1226 Type II. In situ hybridization and immunohistochemistry were used to assess copy number and protein expression of selected genes. Sequenced variants in 47 genes were analyzed using the Illumina TruSeq Amplicon Cancer Panel...
December 1, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27888708/prognostic-value-of-tumor-infiltrating-lymphocytes-for-patients-with-head-and-neck-squamous-cell-carcinoma
#2
Qiaoshi Xu, Chong Wang, Xiaohong Yuan, Zhien Feng, Zhengxue Han
BACKGROUND: The prognostic value of tumor-infiltrating lymphocytes (TILs) in head and neck squamous cell carcinoma (HNSCC) remains controversial. Additionally, there is no standardized approach or cutoff value for evaluating TIL levels. The aim of this study was to establish a feasible method and criterion to assess TIL levels for future clinical practice and research use and to explore the relationship between TIL levels and prognosis. PATIENTS AND METHODS: This retrospective cohort study reviewed the records and pathological sections of 202 patients with HNSCC who were surgically treated at Beijing Stomatological Hospital, Capital Medical University, from January 1998 to January 2011...
November 23, 2016: Translational Oncology
https://www.readbyqxmd.com/read/27865373/extracapsular-spread-in-head-and-neck-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#3
REVIEW
Maxime Mermod, Genrich Tolstonog, Christian Simon, Yan Monnier
Extracapsular spread (ECS) is one of the most important prognostic factors in head and neck squamous cell carcinoma (HNSCC). However, despite its major clinical relevance, there are still a number of important remaining issues regarding this condition. Indeed, standardized diagnostic and grading criteria of ECS are still lacking. The imaging modality of choice for its diagnosis is a matter of debate. Current research looking at the identification of specific biomarkers is ongoing. Recent findings demonstrate a direct correlation between the level of extension of ECS and a poor prognosis...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27780825/transglutaminase-interaction-with-%C3%AE-6-%C3%AE-4-integrin-stimulates-yap1-dependent-%C3%AE-np63%C3%AE-stabilization-and-leads-to-enhanced-cancer-stem-cell-survival-and-tumor-formation
#4
Matthew L Fisher, Candace Kerr, Gautam Adhikary, Daniel Grun, Wen Xu, Jeffrey W Keillor, Richard L Eckert
Transglutaminase 2 (TG2) expression is required for epidermal squamous cell carcinoma cancer stem cell survival. However, the molecular signaling mechanisms triggered by TG2 that mediate this survival action are not well understood. Here we show that TG2 is constitutively expressed in ECS cells where it interacts with α6/β4 integrin to stimulate FAK and Src signaling, leading to phosphoinositide 3 kinase (PI3K) activation of phosphoinositide dependent kinase 1 (PDK1). PDK1 inhibits Hippo signaling, leading to enhanced nuclear accumulation of YAP1, which interacted with and stabilized ΔNp63α to enhance ECS cell spheroid formation, invasion, and migration...
October 25, 2016: Cancer Research
https://www.readbyqxmd.com/read/27679957/transcriptional-analysis-reveals-evidence-of-chronically-impeded-ecm-turnover-and-epithelium-to-mesenchyme-transition-in-scar-tissue-giving-rise-to-marjolin-s-ulcer
#5
Sarthak Sinha, Samuel Su, Matthew Workentine, Natacha Agabalyan, Min Cheng, Vincent Gabriel, Jeff Biernaskie
Marjolin's ulcer (MU) is an aggressive malignancy arising within chronic wounds. A major cause is unhealed burn injuries. This results in well-differentiated squamous cell carcinoma (SCC). This study aimed to elucidate transcriptional changes leading to malignancy by investigating differentially expressed genes in squamous cells present in a SCC compared with MU. MU tumor cells were isolated from histologically confirmed biopsy of SCC within an unhealed burn scar. Epithelial cells (ECs) adjacent to the tumor were co-isolated and a SCC cell line was commercially purchased...
September 20, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27569854/interobserver-reproducibility-of-cervical-lymph-node-measurements-at-ct-in-patients-with-head-and-neck-squamous-cell-carcinoma
#6
M S Chung, K L Cheng, Y J Choi, J L Roh, Y S Lee, S S Lee, J H Lee, J H Baek
AIM: To determine the interobserver reproducibility of measuring cervical lymph nodes at computed tomography (CT) in patients with head and neck squamous cell carcinoma (HNSCC) and to investigate the influence of finding extracapsular spread (ECS) at CT on measurement reliability. MATERIALS AND METHODS: The institutional review board approved the study protocol, and informed consent was obtained. A total of 146 patients with 224 suspicious lymph nodes underwent CT before treatment...
August 25, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27509897/prognostic-significance-of-extracapsular-spread-in-isolated-neck-recurrences-in-head-and-neck-squamous-cell-carcinoma-patients
#7
Xavier León, Antoni Rigó, Nuria Farré, Montserrat López, Jacinto García, Julia de Juan, Miquel Quer
Few studies have analyzed the appearance of extracapsular spread (ECS) in salvage neck dissections carried out after regional recurrence of the disease. The aim of our study was to evaluate the frequency of ECS in patients with an isolated regional recurrence treated with a salvage neck dissection, and to assess the influence of ECS on prognosis. We conducted a retrospective study of 123 patients treated with a salvage neck dissection. Eighty-two patients (66.7 %) had nodes with ECS. Five-year salvage-specific survival for patients without ECS was 77...
August 10, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27225507/utility-of-up-front-transoral-robotic-surgery-in-tailoring-adjuvant-therapy
#8
Neil Gildener-Leapman, Jeehong Kim, Shira Abberbock, Garret W Choby, Rajarsi Mandal, Umamaheswar Duvvuri, Robert L Ferris, Seungwon Kim
BACKGROUND: The purpose of this study was to describe how the up-front transoral robotic surgery (TORS) approach could be used to individually tailor adjuvant therapy based on surgical pathology. METHODS: Between January 2009 and December 2013, 76 patients received TORS for oropharyngeal squamous cell carcinoma (OPSCC). Clinical predictors of adjuvant therapy were analyzed and comparisons were made between recommended treatment guidelines for up-front surgery versus definitive nonsurgical approaches...
August 2016: Head & Neck
https://www.readbyqxmd.com/read/27196434/association-of-extracapsular-spread-with-survival-according-to-human-papillomavirus-status-in-oropharynx-squamous-cell-carcinoma-and-carcinoma-of-unknown-primary-site
#9
Natallia Kharytaniuk, Peter Molony, Seamus Boyle, Gerard O'Leary, Reiltin Werner, Cynthia Heffron, Linda Feeley, Patrick Sheahan
IMPORTANCE: The presence of extracapsular spread (ECS) of metastatic nodes is considered a poor prognosticator in head and neck cancer, with postoperative chemoradiation therapy often recommended over radiation therapy alone in such cases. However, there is less clarity regarding the effect of ECS on human papillomavirus-associated oropharynx squamous cell carcinoma (OPSCC) or carcinoma of unknown primary site (CUP). OBJECTIVE: To investigate the association of ECS according to human papillomavirus status in OPSCC and CUP with survival...
July 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27055978/watchful-waiting-of-the-neck-in-early-stage-oral-cancer-is-unfavourable-for-patients-with-occult-nodal-disease
#10
E A Dik, S M Willems, N A Ipenburg, A J W P Rosenberg, E M Van Cann, R J J van Es
For cT1/2N0 oral squamous cell carcinoma (OSCC), treatment of the neck is a matter of debate. Two treatment strategies were evaluated in this study: selective neck dissection (SND) and watchful waiting (WW). One hundred and twenty-three SND patients and 70 WW patients with cT1/T2N0M0 OSCC of the tongue, floor of mouth, or buccal mucosa were analysed retrospectively. Extracapsular spread (ECS), 3-year overall survival (OS), and disease-specific survival (DSS) were determined. Twenty-nine percent of SND patients and 13% of WW patients had occult nodal disease...
August 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27035619/nrage-is-involved-in-homologous-recombination-repair-to-resist-the-dna-damaging-chemotherapy-and-composes-a-ternary-complex-with-rnf8-bard1-to-promote-cell-survival-in-squamous-esophageal-tumorigenesis
#11
Q Yang, Q Pan, C Li, Y Xu, C Wen, F Sun
NRAGE, a neurotrophin receptor-interacting melanoma antigen-encoding gene homolog, is significantly increased in the nucleus of radioresistant esophageal tumor cell lines and is highly upregulated to promote cell proliferation in esophageal carcinomas (ECs). However, whether the overexpressed NRAGE promotes cell growth by participating in DNA-damage response (DDR) is still unclear. Here we show that NRAGE is required for efficient double-strand breaks (DSBs) repair via homologous recombination repair (HRR) and downregulation of NRAGE greatly sensitizes EC cells to DNA-damaging agents both in vitro and in vivo...
August 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/26970050/increase-in-primary-surgical-treatment-of-t1-and-t2-oropharyngeal-squamous-cell-carcinoma-and-rates-of-adverse-pathologic-features-national-cancer-data-base
#12
Jennifer R Cracchiolo, Shrujal S Baxi, Luc G Morris, Ian Ganly, Snehal G Patel, Marc A Cohen, Benjamin R Roman
BACKGROUND: There has been increasing interest in the primary surgical treatment of patients with early T classification (T1-T2) oropharyngeal squamous cell carcinoma (OPSCC), with the stated goal of de-escalating or avoiding adjuvant treatment. Herein, the authors sought to determine the degree to which this interest has translated into changes in practice patterns, and the rates of adverse postoperative pathologic features. METHODS: Patients with T1 to T2 OPSCC in the National Cancer Data Base who were treated from 2004 through 2013 were categorized as receiving primary surgical or primary radiation-based treatment...
May 15, 2016: Cancer
https://www.readbyqxmd.com/read/26951089/patterns-of-recurrence-after-selective-postoperative-radiation-therapy-for-patients-with-head-and-neck-squamous-cell-carcinoma
#13
Naoya Murakami, Fumihiko Matsumoto, Seiichi Yoshimoto, Yoshinori Ito, Taisuke Mori, Takao Ueno, Keisuke Tuchida, Tairo Kashihara, Kazuma Kobayashi, Ken Harada, Mayuka Kitaguchi, Shuhei Sekii, Rei Umezawa, Kana Takahashi, Koji Inaba, Hiroshi Igaki, Jun Itami
BACKGROUND: The radiation field for patients with postoperative head and neck squamous cell carcinoma is narrower in our institution than in Western countries to reduce late radiation related toxicities. This strategy is at a risk of loco-regional or distant metastasis. However, because patients are more closely checked than in Western countries by every 1 to 2 months intervals and it is supposed that regional recurrences are identified and salvage surgeries are performed more quickly...
2016: BMC Cancer
https://www.readbyqxmd.com/read/26937903/an-ultra-deep-targeted-sequencing-gene-panel-improves-the-prognostic-stratification-of-patients-with-advanced-oral-cavity-squamous-cell-carcinoma
#14
Chun-Ta Liao, Shu-Jen Chen, Li-Yu Lee, Chuen Hsueh, Lan-Yan Yang, Chien-Yu Lin, Kang-Hsing Fan, Hung-Ming Wang, Shu-Hang Ng, Chih-Hung Lin, Chung-Kan Tsao, I-How Chen, Kai-Ping Chang, Shiang-Fu Huang, Chung-Jan Kang, Hua-Chien Chen, Tzu-Chen Yen
An improved prognostic stratification of patients with oral cavity squamous cell carcinoma (OSCC) and pathologically positive (pN+) nodes is urgently needed. Here, we sought to examine whether an ultra-deep targeted sequencing (UDT-Seq) gene panel may improve the prognostic stratification in this patient group.A mutation-based signature affecting 10 genes (including genetic mutations in 6 oncogenes and 4 tumor suppressor genes) was devised to predict disease-free survival (DFS) in 345 primary tumor specimens obtained from pN+ OSCC patients...
February 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26804163/vegf-a-acts-via-neuropilin-1-to-enhance-epidermal-cancer-stem-cell-survival-and-formation-of-aggressive-and-highly-vascularized-tumors
#15
D Grun, G Adhikary, R L Eckert
We identify a limited subpopulation of epidermal cancer stem cells (ECS cells), in squamous cell carcinoma, that form rapidly growing, invasive and highly vascularized tumors, as compared with non-stem cancer cells. These ECS cells grow as non-attached spheroids, and display enhanced migration and invasion. We show that ECS cell-produced vascular endothelial growth factor (VEGF)-A is required for the maintenance of this phenotype, as knockdown of VEGF-A gene expression or treatment with VEGF-A-inactivating antibody reduces these responses...
August 18, 2016: Oncogene
https://www.readbyqxmd.com/read/26796597/mdm2-gene-amplification-in-esophageal-carcinoma
#16
Maike Michalk, Jeannine Meinrath, Helen Künstlinger, Ulrike Koitzsch, Uta Drebber, Sabine Merkelbach-Bruse, Elfriede Bollschweiler, Michael Kloth, Wolfgang Hartmann, Arnulf Hölscher, Alexander Quaas, Peter P Grimminger, Margarete Odenthal
Esophageal cancer (EC) is one of the most common malignancies diagnosed in the Western world with an increasing incidence noted for esophageal adenocarcinoma (EAC). Despite improvements in staging, surgical procedures and postoperative treatments, the overall survival of patients with EC remains low. Murine double minute‑2 (MDM2) acts as an oncogene by inducing the degradation of the tumor‑suppressor protein TP53. In order to evaluate the MDM2 gene amplification status in EAC and squamous cell carcinoma (SCC), we established a quantitative PCR (qPCR) assay, screening a total of 127 esophageal carcinoma cases for MDM2 amplification...
April 2016: Oncology Reports
https://www.readbyqxmd.com/read/26514096/influence-of-extracapsular-nodal-spread-extent-on-prognosis-of-oral-squamous-cell-carcinoma
#17
Volkert B Wreesmann, Nora Katabi, Frank L Palmer, Pablo H Montero, Jocelyn C Migliacci, Mithat Gönen, Diane Carlson, Ian Ganly, Jatin P Shah, Ronald Ghossein, Snehal G Patel
BACKGROUND: An objective definition of clinically relevant extracapsular nodal spread (ECS) in head and neck squamous cell carcinoma (SCC) is unavailable. METHODS: Pathologic review of 245 pathologically positive oral cavity SCC neck dissection specimens was performed. The presence/absence of ECS, its extent (in millimeters), and multiple nodal and primary tumor risk factors were related to disease-specific survival (DSS) at a follow-up of 73 months. RESULTS: ECS was detected in 109 patients (44%)...
April 2016: Head & Neck
https://www.readbyqxmd.com/read/26473842/cancer-microenvironment-what-can-we-learn-from-the-stem-cell-niche
#18
REVIEW
Lukas Lacina, Jan Plzak, Ondrej Kodet, Pavol Szabo, Martin Chovanec, Barbora Dvorankova, Karel Smetana
Epidermal stem cells (ESCs) are crucial for maintenance and self- renewal of skin epithelium and also for regular hair cycling. Their role in wound healing is also indispensable. ESCs reside in a defined outer root sheath portion of hair follicle-also known as the bulge region. ECS are also found between basal cells of the interfollicular epidermis or mucous membranes. The non-epithelial elements such as mesenchymal stem cell-like elements of dermis or surrounding adipose tissue can also contribute to this niche formation...
2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26459312/evaluation-of-cannabinoid-cb1-and-cb2-receptors-expression-in-mobile-tongue-squamous-cell-carcinoma-associations-with-clinicopathological-parameters-and-patients-survival
#19
Stamatios Theocharis, Constantinos Giaginis, Paraskevi Alexandrou, Jose Rodriguez, Jason Tasoulas, Eugene Danas, Efstratios Patsouris, Jerzy Klijanienko
Cannabinoid receptors (CB1R and CB2R) constitute essential members of the endocannabinoid system (ECS) which participates in many different functions indispensable to homeostatic regulation in several tissues, exerting also antitumorigenic effects. The present study aimed to assess the clinical significance of CB1R and CB2R protein expression in mobile tongue squamous cell carcinoma (SCC). CB1R and CB2R expression was assessed immunohistochemically on 28 mobile tongue SCC tissue samples and was analyzed in relation with clinicopathological characteristics and overall and disease-free patients' survival...
March 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26439759/evaluation-of-the-level-of-progression-of-extracapsular-spread-for-cervical-lymph-node-metastasis-in-oral-squamous-cell-carcinoma
#20
S Yamada, S Yanamoto, S Otani, T Hasegawa, M Miyakoshi, T Minamikawa, N Ohga, T Kamata, T Komori, Y Kitagawa, H Kurita, M Umeda
Only a few reports on the level of progression of extracapsular spread (ECS) have been published. The aim of this study was to evaluate the efficacy of the level of progression of ECS in identifying those patients with oral squamous cell carcinoma (OSCC) at a high risk of recurrence who would benefit most from the intensification of adjuvant therapy. The level of progression of ECS for cervical lymph node metastasis in OSCC was divided into three types (A-C), and their relationships with patient prognosis were examined...
February 2016: International Journal of Oral and Maxillofacial Surgery
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