Jingyao Chen, Siqi Dai, Lei Zhao, Yiman Peng, Chongen Sun, Hongling Peng, Qian Zhong, Yuan Quan, Yue Li, Xuelan Chen, Xiangyu Pan, Ailing Zhong, Manli Wang, Mengsha Zhang, Shengyong Yang, You Lu, Zhong Lian, Yu Liu, Shengtao Zhou, Zhengyu Li, Feifei Na, Chong Chen
Endometrial cancer (EC) is the most common female reproductive tract cancer and its incidence has been continuously increasing in recent years. The underlying mechanisms of EC tumorigenesis remain unclear, and efficient target therapies are lacking, for both of which feasible endometrial cancer animal models are essential but currently limited. Here, an organoid and genome editing-based strategy to generate primary, orthotopic, and driver-defined ECs in mice is reported. These models faithfully recapitulate the molecular and pathohistological characteristics of human diseases...
June 20, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)