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ECS squamous cell carcinoma

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https://www.readbyqxmd.com/read/28487611/performance-of-18-fluoro-2-deoxyglucose-positron-emission-tomography-for-esophageal-cancer-screening
#1
Masau Sekiguchi, Takashi Terauchi, Yasuo Kakugawa, Naoki Shimada, Yutaka Saito, Takahisa Matsuda
AIM: To evaluate the performance of 18-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) for esophageal cancer (EC) screening. METHODS: We retrospectively analyzed the data of consecutive asymptomatic individuals who underwent FDG-PET and esophagogastroduodenoscopy (EGD) simultaneously for cancer screening at our institution from February 2004 to March 2013. In total, 14790 FDG-PET and EGD procedures performed for 8468 individuals were included in this study, and the performance of FDG-PET for EC screening was assessed by comparing the results of FDG-PET and EGD, considering the latter as the reference...
April 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28351561/salvage-surgery-in-recurrent-head-and-neck-squamous-cell-carcinoma-oncologic-outcome-and-predictors-of-disease-free-survival
#2
Marc Hamoir, Emma Holvoet, Jerôme Ambroise, Benoît Lengelé, Sandra Schmitz
OBJECTIVE: Salvage surgery in recurrent SCCHN is associated with poor outcomes. This study aimed to better identify suitable surgical candidates and those at high risk of new recurrence. MATERIALS AND METHODS: Single-center retrospective analysis of 109 patients undergoing salvage surgery for recurrent SCCHN. Univariate and multivariate analyses were used to identify prognostic factors affecting disease-free survival (DFS). RESULTS: The following factors showed a significant impact on DFS: Disease-free interval >6months [HR 0...
April 2017: Oral Oncology
https://www.readbyqxmd.com/read/28347602/prognostic-significance-of-extracapsular-spread-of-lymph-node-metastasis-from-oral-squamous-cell-carcinoma-in-the-clinically-negative-neck
#3
P Suton, I Salaric, M Granic, D Mueller, I Luksic
The presence of extracapsular spread (ECS) in patients with oral squamous cell carcinoma (OSCC) indicates a poor prognosis and is associated with a higher risk of regional recurrence and distant metastasis. The aim of this study was to analyse this important feature of cervical lymph nodes in the clinically node-negative setting. The study included 61 patients with clinically T1-T3N0 OSCC who underwent primary surgical treatment; 52 were male and nine were female, and their median age was 57 years. The 5-year disease-free survival, disease-specific survival, and overall survival rates were 30...
March 24, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28252823/node-positive-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck-survival-high-risk-features-and-adjuvant-chemoradiotherapy-outcomes
#4
Misha Amoils, Carolyn S Lee, John Sunwoo, Sumaira Z Aasi, Wendy Hara, Jinah Kim, Davud Sirjani, A Dimitrios Colevas, Anne Lynn S Chang, Vasu Divi
BACKGROUND: Data lacks to guide treatment of regionally metastatic cutaneous head and neck squamous cell carcinoma (HNSCC). METHODS: We conducted a retrospective review of 80 patients treated for regionally metastatic cutaneous HNSCC. The effect of various clinicopathologic variables on overall survival (OS) was investigated, in addition to outcomes by treatment modality. RESULTS: On multivariate regression, cutaneous primary >2 cm (p = ...
May 2017: Head & Neck
https://www.readbyqxmd.com/read/28188953/minimizing-adjuvant-treatment-after-transoral-robotic-surgery-through-surgical-margin-revision-and-exclusion-of-radiographic-extracapsular-extension-a-prospective-observational-cohort-study
#5
Benoit Morisod, Ioana I Venara-Vulpe, Stephen Alzuphar, Yan Monnier, Massimo Bongiovanni, Patric Hagmann, Hanan Bouchaab, Jean Bourhis, Christian Simon
BACKGROUND: We investigated in a prospective cohort of patients treated with trans-oral robotic surgery (TORS) for oropharyngeal cancer (OPC), who were selected for the absence of radiographic extra-capsular extension (ECS) and surgically revised for inadequate margins, the possibility of reducing adjuvant radiation (RT)/chemo-radiation therapy (CRT) without jeopardizing tumor control and functional outcome. METHODS: We conducted a prospective observational cohort of patients treated with TORS for oropharyngeal cancer...
February 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/28071618/clinico-pathological-factors-affecting-lymph-node-yield-in-indian-patients-with-locally-advanced-squamous-cell-carcinoma-of-mandibular-gingivo-buccal-sulcus
#6
S S Muttagi, B R Patil, A S Godhi, D K Arora, S R Hallikerimath, A D Kale
AIM: Lymph node yield (LNY) is a valid marker of prognosis in oral cancer. Precise estimation of LNY in Indian patients with T3/T4 gingivobuccal sulcus squamous cell carcinoma (GBS-SCC) has not been well documented. Hence, the primary objective of the study was to determine the LNY in patients with T3/T4 SCC of mandibular GBS, and the secondary objective was to study the association of LNY with clinicopathological factors such as tumor thickness, histological differentiation, number of positive nodes, and extracapsular spread (ECS)...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/27992314/cytotoxic-and-genotoxic-effects-of-electronic-cigarette-liquids-on-human-mucosal-tissue-cultures-of-the-oropharynx
#7
Christian Welz, Martin Canis, Sabina Schwenk-Zieger, Sven Becker, Vincent Stucke, Friedrich Ihler, Philipp Baumeister
The popularity of electronic cigarettes (ECs) is rapidly growing and ECs are claimed to be an uncritically regarded alternative to conventional cigarettes. The mucosal tissue of the upper aerodigestive tract (UADT) is the first contact organ for xenobiotics such as liquids of ECs. The aim of this study is to investigate the bimolecular effects of e-liquids on human pharyngeal tissue cultures to evaluate whether e-liquids and their components present a risk factor for head and neck squamous cell carcinoma. Fresh tissue samples of healthy oropharyngeal mucosa were assembled into mucosal tissue cultures...
2016: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/27905110/distinct-molecular-landscapes-between-endometrioid-and-nonendometrioid-uterine-carcinomas
#8
Nathaniel L Jones, Joanne Xiu, Sudeshna Chatterjee-Paer, Alexandre Buckley de Meritens, William M Burke, Ana I Tergas, Jason D Wright, June Y Hou
Endometrial carcinoma (EC) is traditionally characterized as endometrioid and nonendometrioid based on histopathologic phenotypes. Molecular-based classifications have been proposed, but are not widely implemented. Herein we examine molecular profiles between EC histologic subtypes. 3133 ECs were submitted between March 2011 and July 2014: 1634 Type I and 1226 Type II. In situ hybridization and immunohistochemistry were used to assess copy number and protein expression of selected genes. Sequenced variants in 47 genes were analyzed using the Illumina TruSeq Amplicon Cancer Panel...
March 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27888708/prognostic-value-of-tumor-infiltrating-lymphocytes-for-patients-with-head-and-neck-squamous-cell-carcinoma
#9
Qiaoshi Xu, Chong Wang, Xiaohong Yuan, Zhien Feng, Zhengxue Han
BACKGROUND: The prognostic value of tumor-infiltrating lymphocytes (TILs) in head and neck squamous cell carcinoma (HNSCC) remains controversial. Additionally, there is no standardized approach or cutoff value for evaluating TIL levels. The aim of this study was to establish a feasible method and criterion to assess TIL levels for future clinical practice and research use and to explore the relationship between TIL levels and prognosis. PATIENTS AND METHODS: This retrospective cohort study reviewed the records and pathological sections of 202 patients with HNSCC who were surgically treated at Beijing Stomatological Hospital, Capital Medical University, from January 1998 to January 2011...
November 23, 2016: Translational Oncology
https://www.readbyqxmd.com/read/27865373/extracapsular-spread-in-head-and-neck-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#10
REVIEW
Maxime Mermod, Genrich Tolstonog, Christian Simon, Yan Monnier
Extracapsular spread (ECS) is one of the most important prognostic factors in head and neck squamous cell carcinoma (HNSCC). However, despite its major clinical relevance, there are still a number of important remaining issues regarding this condition. Indeed, standardized diagnostic and grading criteria of ECS are still lacking. The imaging modality of choice for its diagnosis is a matter of debate. Current research looking at the identification of specific biomarkers is ongoing. Recent findings demonstrate a direct correlation between the level of extension of ECS and a poor prognosis...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27780825/transglutaminase-interaction-with-%C3%AE-6-%C3%AE-4-integrin-stimulates-yap1-dependent-%C3%AE-np63%C3%AE-stabilization-and-leads-to-enhanced-cancer-stem-cell-survival-and-tumor-formation
#11
Matthew L Fisher, Candace Kerr, Gautam Adhikary, Dan Grun, Wen Xu, Jeffrey W Keillor, Richard L Eckert
Transglutaminase 2 (TG2) expression is required for epidermal squamous cell carcinoma cancer stem cell survival. However, the molecular signaling mechanisms triggered by TG2 that mediate this survival action are not well understood. Here we show that TG2 is constitutively expressed in ECS cells, where it interacts with α6/β4 integrin to stimulate FAK and Src signaling, leading to PI3K activation of phosphoinositide-dependent kinase 1 (PDK1). PDK1 inhibits Hippo signaling, leading to enhanced nuclear accumulation of YAP1, which interacted with and stabilized ΔNp63α to enhance epidermal squamous cell carcinoma spheroid formation, invasion, and migration...
December 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/27679957/transcriptional-analysis-reveals-evidence-of-chronically-impeded-ecm-turnover-and-epithelium-to-mesenchyme-transition-in-scar-tissue-giving-rise-to-marjolin-s-ulcer
#12
Sarthak Sinha, Samuel Su, Matthew Workentine, Natacha Agabalyan, Min Cheng, Vincent Gabriel, Jeff Biernaskie
Marjolin's ulcer (MU) is an aggressive malignancy arising within chronic wounds. A major cause is unhealed burn injuries. This results in well-differentiated squamous cell carcinoma (SCC). This study aimed to elucidate transcriptional changes leading to malignancy by investigating differentially expressed genes in squamous cells present in a SCC compared with MU. MU tumor cells were isolated from histologically confirmed biopsy of SCC within an unhealed burn scar. Epithelial cells (ECs) adjacent to the tumor were co-isolated and a SCC cell line was commercially purchased...
January 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27569854/interobserver-reproducibility-of-cervical-lymph-node-measurements-at-ct-in-patients-with-head-and-neck-squamous-cell-carcinoma
#13
M S Chung, K L Cheng, Y J Choi, J L Roh, Y S Lee, S S Lee, J H Lee, J H Baek
AIM: To determine the interobserver reproducibility of measuring cervical lymph nodes at computed tomography (CT) in patients with head and neck squamous cell carcinoma (HNSCC) and to investigate the influence of finding extracapsular spread (ECS) at CT on measurement reliability. MATERIALS AND METHODS: The institutional review board approved the study protocol, and informed consent was obtained. A total of 146 patients with 224 suspicious lymph nodes underwent CT before treatment...
December 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27509897/prognostic-significance-of-extracapsular-spread-in-isolated-neck-recurrences-in-head-and-neck-squamous-cell-carcinoma-patients
#14
Xavier León, Antoni Rigó, Nuria Farré, Montserrat López, Jacinto García, Julia de Juan, Miquel Quer
Few studies have analyzed the appearance of extracapsular spread (ECS) in salvage neck dissections carried out after regional recurrence of the disease. The aim of our study was to evaluate the frequency of ECS in patients with an isolated regional recurrence treated with a salvage neck dissection, and to assess the influence of ECS on prognosis. We conducted a retrospective study of 123 patients treated with a salvage neck dissection. Eighty-two patients (66.7 %) had nodes with ECS. Five-year salvage-specific survival for patients without ECS was 77...
January 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27225507/utility-of-up-front-transoral-robotic-surgery-in-tailoring-adjuvant-therapy
#15
Neil Gildener-Leapman, Jeehong Kim, Shira Abberbock, Garret W Choby, Rajarsi Mandal, Umamaheswar Duvvuri, Robert L Ferris, Seungwon Kim
BACKGROUND: The purpose of this study was to describe how the up-front transoral robotic surgery (TORS) approach could be used to individually tailor adjuvant therapy based on surgical pathology. METHODS: Between January 2009 and December 2013, 76 patients received TORS for oropharyngeal squamous cell carcinoma (OPSCC). Clinical predictors of adjuvant therapy were analyzed and comparisons were made between recommended treatment guidelines for up-front surgery versus definitive nonsurgical approaches...
August 2016: Head & Neck
https://www.readbyqxmd.com/read/27196434/association-of-extracapsular-spread-with-survival-according-to-human-papillomavirus-status-in-oropharynx-squamous-cell-carcinoma-and-carcinoma-of-unknown-primary-site
#16
Natallia Kharytaniuk, Peter Molony, Seamus Boyle, Gerard O'Leary, Reiltin Werner, Cynthia Heffron, Linda Feeley, Patrick Sheahan
IMPORTANCE: The presence of extracapsular spread (ECS) of metastatic nodes is considered a poor prognosticator in head and neck cancer, with postoperative chemoradiation therapy often recommended over radiation therapy alone in such cases. However, there is less clarity regarding the effect of ECS on human papillomavirus-associated oropharynx squamous cell carcinoma (OPSCC) or carcinoma of unknown primary site (CUP). OBJECTIVE: To investigate the association of ECS according to human papillomavirus status in OPSCC and CUP with survival...
July 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27055978/watchful-waiting-of-the-neck-in-early-stage-oral-cancer-is-unfavourable-for-patients-with-occult-nodal-disease
#17
E A Dik, S M Willems, N A Ipenburg, A J W P Rosenberg, E M Van Cann, R J J van Es
For cT1/2N0 oral squamous cell carcinoma (OSCC), treatment of the neck is a matter of debate. Two treatment strategies were evaluated in this study: selective neck dissection (SND) and watchful waiting (WW). One hundred and twenty-three SND patients and 70 WW patients with cT1/T2N0M0 OSCC of the tongue, floor of mouth, or buccal mucosa were analysed retrospectively. Extracapsular spread (ECS), 3-year overall survival (OS), and disease-specific survival (DSS) were determined. Twenty-nine percent of SND patients and 13% of WW patients had occult nodal disease...
August 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27035619/nrage-is-involved-in-homologous-recombination-repair-to-resist-the-dna-damaging-chemotherapy-and-composes-a-ternary-complex-with-rnf8-bard1-to-promote-cell-survival-in-squamous-esophageal-tumorigenesis
#18
Q Yang, Q Pan, C Li, Y Xu, C Wen, F Sun
NRAGE, a neurotrophin receptor-interacting melanoma antigen-encoding gene homolog, is significantly increased in the nucleus of radioresistant esophageal tumor cell lines and is highly upregulated to promote cell proliferation in esophageal carcinomas (ECs). However, whether the overexpressed NRAGE promotes cell growth by participating in DNA-damage response (DDR) is still unclear. Here we show that NRAGE is required for efficient double-strand breaks (DSBs) repair via homologous recombination repair (HRR) and downregulation of NRAGE greatly sensitizes EC cells to DNA-damaging agents both in vitro and in vivo...
August 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/26970050/increase-in-primary-surgical-treatment-of-t1-and-t2-oropharyngeal-squamous-cell-carcinoma-and-rates-of-adverse-pathologic-features-national-cancer-data-base
#19
Jennifer R Cracchiolo, Shrujal S Baxi, Luc G Morris, Ian Ganly, Snehal G Patel, Marc A Cohen, Benjamin R Roman
BACKGROUND: There has been increasing interest in the primary surgical treatment of patients with early T classification (T1-T2) oropharyngeal squamous cell carcinoma (OPSCC), with the stated goal of de-escalating or avoiding adjuvant treatment. Herein, the authors sought to determine the degree to which this interest has translated into changes in practice patterns, and the rates of adverse postoperative pathologic features. METHODS: Patients with T1 to T2 OPSCC in the National Cancer Data Base who were treated from 2004 through 2013 were categorized as receiving primary surgical or primary radiation-based treatment...
May 15, 2016: Cancer
https://www.readbyqxmd.com/read/26951089/patterns-of-recurrence-after-selective-postoperative-radiation-therapy-for-patients-with-head-and-neck-squamous-cell-carcinoma
#20
Naoya Murakami, Fumihiko Matsumoto, Seiichi Yoshimoto, Yoshinori Ito, Taisuke Mori, Takao Ueno, Keisuke Tuchida, Tairo Kashihara, Kazuma Kobayashi, Ken Harada, Mayuka Kitaguchi, Shuhei Sekii, Rei Umezawa, Kana Takahashi, Koji Inaba, Hiroshi Igaki, Jun Itami
BACKGROUND: The radiation field for patients with postoperative head and neck squamous cell carcinoma is narrower in our institution than in Western countries to reduce late radiation related toxicities. This strategy is at a risk of loco-regional or distant metastasis. However, because patients are more closely checked than in Western countries by every 1 to 2 months intervals and it is supposed that regional recurrences are identified and salvage surgeries are performed more quickly...
March 7, 2016: BMC Cancer
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