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https://www.readbyqxmd.com/read/27896137/lymph-node-or-perineural-invasion-is-associated-with-low-mir-15a-mir-34c-and-mir-199b-levels-in-head-and-neck-squamous-cell-carcinoma
#1
Lucas O Sousa, Lays M Sobral, Camila S Matsumoto, Fabiano P Saggioro, Rossana V M López, Rodrigo A Panepucci, Carlos Curti, Wilson A Silva, Lewis J Greene, Andréia M Leopoldino
BACKGROUND: MicroRNAs (miRNAs or miRs) are post-transcriptional regulators of eukaryotic cells and knowledge of differences in miR levels may provide new approaches to diagnosis and therapy. METHODS: The present study measured the levels of nine miRs in head and neck squamous cell carcinomas (HNSCC) and determined whether clinical pathological features are associated with differences in miR levels. SET (I2PP2A) and PTEN protein levels were also measured, since their levels can be regulated by miR-199b and miR-21, respectively...
December 2016: BBA Clinical
https://www.readbyqxmd.com/read/27884018/blood-transfusion-during-radical-chemo-radiotherapy-does-not-reduce-tumour-hypoxia-in-squamous-cell-cancer-of-the-head-and-neck
#2
Liam Welsh, Rafal Panek, Angela Riddell, Kee Wong, Martin O Leach, Mahvash Tavassoli, Durdana Rahman, Maria Schmidt, Tara Hurley, Lorna Grove, Thomas Richards, Dow-Mu Koh, Christopher Nutting, Kevin Harrington, Kate Newbold, Shreerang Bhide
BACKGROUND: Patients with head and neck squamous cell carcinoma (HNSCC) undergoing radical chemo-radiation (CRT) frequently receive transfusion with packed red cells (PRCT) during radiotherapy on the basis that PRCT increases tumour oxygenation and overcomes hypoxia-induced radio-resistance. This is likely to be a significant oversimplification given the fact that tumour hypoxia is the result of several intrinsic and extrinsic factors, including many that are not directly related to serum haemoglobin (Hb)...
November 24, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27865360/langerhans-cell-number-is-a-strong-and-independent-prognostic-factor-for-head-and-neck-squamous-cell-carcinomas
#3
Nadège Kindt, Géraldine Descamps, Imelda Seminerio, Justine Bellier, Jérôme R Lechien, Charles Pottier, Denis Larsimont, Fabrice Journé, Philippe Delvenne, Sven Saussez
OBJECTIVES: Head and neck squamous cell carcinomas (HNSCCs) exhibit great biological heterogeneity and relatively poor prognosis. Tobacco and alcohol consumption is involved in the cause of the majority of these cancers, but over the last several years, Human Papilloma Virus (HPV) infection has increased specifically in oropharyngeal cancers and become an additional risk factor. Here, we evaluated the number of Langerhans cells (LCs) in HNSCC and reporting its prognostic power in comparison to other risk factors...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27863406/stc2-promotes-head-and-neck-squamous-cell-carcinoma-metastasis-through-modulating-the-pi3k-akt-snail-signaling
#4
Shuwen Yang, Qinghai Ji, Bin Chang, Yan Wang, Yongxue Zhu, Duanshu Li, Caiping Huang, Yulong Wang, Guohua Sun, Ling Zhang, Qing Guan, Jun Xiang, Wenjun Wei, Zhongwu Lu, Tian Liao, Jiao Meng, Ziliang Wang, Ben Ma, Li Zhou, Yu Wang, Gong Yang
The mammalian peptide hormone stanniocalcin 2 (STC2) plays an oncogenic role in many human cancers. However, the exact function of STC2 in human head and neck squamous cell carcinoma (HNSCC) is unclear. We aimed to examine the function and clinical significance of STC2 in HNSCC. Using in vitro and in vivo assays, we show that overexpression of STC2 suppressed cell apoptosis, promoted cell proliferation, migration, invasion, and cell cycle arrest at the G1/S transition. By contrast, silencing of STC2 inhibited these activities...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27837418/multi-slice-spect-ct-vs-lymphoscintigraphy-and-intraoperative-gamma-ray-probe-for-sentinel-node-mapping-in-hnscc
#5
C M Meerwein, T Sekine, P Veit-Haibach, M G Bredell, G F Huber, M W Huellner
To assess the diagnostic potential of multi-slice single-photon emission computed tomography/computed tomography (SPECT/CT) for preoperative sentinel node (SN) mapping in early stage head and neck squamous cell carcinoma (HNSCC). Retrospective case-control study including data of consecutive HNSCC patients treated between November 2011 and December 2015. The diagnostic accuracy of multi-slice SPECT/CT was assessed with regard to the gold standard intraoperative gamma ray detection probe, using McNemar's test and calculating the area under the ROC curve...
November 11, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27821180/utility-of-suvmax-on-18-f-fdg-pet-in-detecting-cervical-nodal-metastases
#6
Rebecca S M Lim, Shakher Ramdave, Paul Beech, Baki Billah, Md Nazmul Karim, Julian A Smith, Adnan Safdar, Elizabeth Sigston
BACKGROUND: The presence of cervical lymph node metastasis is an important prognostic factor for patients with head and neck squamous cell carcinomas (HNSCC). Accurate assessment of lymph node metastasis in these patients is essential for appropriate prognostic and management purposes. Here, we evaluated the effectiveness of the maximum standardized uptake value (SUVmax) on positron emission tomography (PET) in assessing lymph node metastasis in HNSCC prior to surgery. METHODS: A retrospective review of 74 patients with HNSCC who underwent PET/CT prior to neck dissection were examined...
November 8, 2016: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/27780223/lim-only-protein-4-lmo4-and-lim-domain-binding-protein-1-ldb1-promote-growth-and-metastasis-of-human-head-and-neck-cancer-lmo4-and-ldb1-in-head-and-neck-cancer
#7
Elizabeth A Simonik, Ying Cai, Katherine N Kimmelshue, Dana M Brantley-Sieders, Holli A Loomans, Claudia D Andl, Grant M Westlake, Victoria M Youngblood, Jin Chen, Wendell G Yarbrough, Brandee T Brown, Lalitha Nagarajan, Stephen J Brandt
Squamous cell carcinoma of the head and neck (HNSCC) accounts for more than 300,000 deaths worldwide per year as a consequence of tumor cell invasion of adjacent structures or metastasis. LIM-only protein 4 (LMO4) and LIM-domain binding protein 1 (LDB1), two directly interacting transcriptional adaptors that have important roles in normal epithelial cell differentiation, have been associated with increased metastasis, decreased differentiation, and shortened survival in carcinoma of the breast. Here, we implicate two LDB1-binding proteins, single-stranded binding protein 2 (SSBP2) and 3 (SSBP3), in controlling LMO4 and LDB1 protein abundance in HNSCC and in regulating specific tumor cell functions in this disease...
2016: PloS One
https://www.readbyqxmd.com/read/27760788/dysregulation-of-runx2-activin-a-axis-upon-mir376c-downregulation-promotes-lymph-node-metastasis-in-head-and-neck-squamous-cell-carcinoma
#8
Wei-Min Chang, Yuan-Feng Lin, Chia-Yi Su, Hsuan-Yu Peng, Yu-Chan Chang, Tsung-Ching Lai, Guan-Hsun Wu, Yuan-Ming Hsu, Li-Hsing Chi, Jenn-Ren Hsiao, Chi-Long Chen, Jang-Yang Chang, Yi-Shing Shieh, Michael Hsiao, Shine-Gwo Shiah
Epigenetic correlates of head and neck cancer may illuminate its pathogenic roots. Through a gene set enrichment analysis, we found that the oncogenic transcription factor RUNX2 is widely upregulated in head and neck squamous cell carcinoma (HNSCC) with lymph node metastasis, where it also predicts poor prognosis in HNSCC patients. Enforced expression of ectopic RUNX2 promoted the metastatic capabilities of HNSCC, whereas RUNX2 silencing inhibited these features. Mechanistic investigations showed that manipulating levels of activin A (INHBA) could rescue or compromise the RUNX2-mediated metastatic capabilities of HNSCC cells...
October 19, 2016: Cancer Research
https://www.readbyqxmd.com/read/27742432/correlation-study-between-intravoxel-incoherent-motion-mri-and-dynamic-contrast-enhanced-mri-in-head-and-neck-squamous-cell-carcinoma-evaluation-in-primary-tumors-and-metastatic-nodes
#9
Simona Marzi, Francesca Piludu, Chiara Forina, Giuseppe Sanguineti, Renato Covello, Giuseppe Spriano, Antonello Vidiri
OBJECTIVE: To correlate intravoxel incoherent motion (IVIM) imaging and dynamic contrast-enhanced (DCE) MRI in head and neck squamous cell carcinoma (HNSCC). METHODS: Forty untreated patients with HNSCC were included retrospectively in the study. Perfusion fraction f, diffusion coefficient D and perfusion-related diffusion coefficient D* were extracted by bi-exponential fitting of IVIM data. Semi-quantitative DCE-MRI parameters, including positive enhancement integral (PEI) and maximum slope of increase (MSI), were calculated...
October 11, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27733374/phase-ii-trial-of-post-operative-radiotherapy-with-concurrent-cisplatin-plus-panitumumab-in-patients-with-high-risk-resected-head-and-neck-cancer
#10
R L Ferris, J L Geiger, S Trivedi, N C Schmitt, D E Heron, J T Johnson, S Kim, U Duvvuri, D A Clump, J E Bauman, J P Ohr, W E Gooding, A Argiris
BACKGROUND: Treatment intensification for resected, high-risk, head and neck squamous cell carcinoma (HNSCC) is an area of active investigation with novel adjuvant regimens under study. In this trial, the epidermal growth-factor receptor (EGFR) pathway was targeted using the IgG2 monoclonal antibody panitumumab in combination with cisplatin chemoradiotherapy (CRT) in high-risk, resected HNSCC. PATIENTS AND METHODS: Eligible patients included resected pathologic stage III or IVA squamous cell carcinoma of the oral cavity, larynx, hypopharynx, or human-papillomavirus (HPV)-negative oropharynx, without gross residual tumor, featuring high-risk factors (margins <1 mm, extracapsular extension, perineural or angiolymphatic invasion, or ≥2 positive lymph nodes)...
October 11, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27713748/indomethacin-treatment-of-mice-with-premalignant-oral-lesions-sustains-cytokine-production-and-slows-progression-to-cancer
#11
Sara D Johnson, M Rita I Young
Current treatment options for head and neck squamous cell carcinoma (HNSCC) patients are often ineffective due to tumor-localized and systemic immunosuppression. Using the 4-NQO mouse model of oral carcinogenesis, this study showed that premalignant oral lesion cells produce higher levels of the immune modulator, PGE2, compared to HNSCC cells. Inhibiting prostaglandin production of premalignant lesion cells with the pan-cyclooxygenase inhibitor indomethacin stimulated their induction of spleen cell cytokine production...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27706614/characterization-of-gene-methylation-in-human-papillomavirus-associated-head-and-neck-squamous-cell-carcinoma
#12
H Z Zhang, C G Shan, A P Huang, J M Wang
Head and neck squamous cell carcinoma (HNSCC) has become one of the most common forms of cancer worldwide. Hypermethylation-induced silencing of tumor-associated gene has been proposed as an important cofactor in cancer pathology. This paper aimed to characterize the gene methylation patterns in human papillomavirus (HPV) associated-HNSCC. TIMP3 and APC methylation status in neoplastic (N = 92) and non-neoplastic tissues (N = 92) of HNSCC as well as their association with HPV infection were investigated via methylation-specific PCR assays...
August 26, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27679399/influence-of-volumetric-4-methyl-11-c-thiothymidine-pet-ct-parameters-for-prediction-of-the-clinical-outcome-of-head-and-neck-cancer-patients
#13
Hiroshi Hoshikawa, Terushige Mori, Yukito Maeda, Satoshi Takahashi, Yohei Ouchi, Yuka Yamamoto, Yoshihiro Nishiyama
OBJECTIVE: This prospective study compared the value of pretreatment 4'-[methyl-(11)C]-thiothymidine ((11)C-4DST) volumetric parameters and those of 2-deoxy-2-[18F] fluoro-D-glucose ((18)F-FDG) in predicting the clinical outcome in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: Fifty patients with HNSCC underwent (11)C-4DST PET/CT and (18)F-FDG PET/CT prior to anticancer therapy. (18)F-FDG metabolic tumor volume ((18)F-FDG MTV) and total lesion glycolysis (TLG) were calculated from (18)F-FDG PET, and (11)C-4DST MTV and total lesion proliferation (TLP) were calculated from (11)C-4DST PET...
September 27, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27667722/prevalence-of-human-papillomavirus-types-viral-load-and-physical-status-of-hpv16-in-head-and-neck-squamous-cell-carcinoma-from-the-south-swedish-health-care-region
#14
Helena Faust, Erika Eldenhed Alwan, Alexander Roslin, Johan Wennerberg, Ola Forslund
Incidence of human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) is rising in several countries. Intriguingly, large variations of HPV16 viral load and different proportions of the physical viral status among HNSCC have been reported. We analysed fresh biopsies of 275 HNSCC patients from the South Swedish Health Care Region for HPV types with modified general primer PCR and Luminex. Seventy-eight HPV16-positive HNSCC cases were further investigated for viral DNA load and physical status using quantitative PCR for HPV E2 and E7 genes...
November 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27658780/hox-genes-potential-candidates-for-the-progression-of-laryngeal-squamous-cell-carcinoma
#15
Rafaela de Barros E Lima Bueno, Anelisa Ramão, Daniel Guariz Pinheiro, Cleidson Padua Alves, Vinicius Kannen, Achim A Jungbluth, Luiza Ferreira de Araújo, Bruna Rodrigues Muys, Aline Simoneti Fonseca, Jessica Rodrigues Plaça, Rodrigo Alexandre Panepucci, Luciano Neder, Fabiano P Saggioro, Rui Celso M Mamede, David Livingstone Alves Figueiredo, Wilson Araújo Silva
Laryngeal squamous cell carcinoma (LSCC) is a very aggressive cancer, considered to be a subtype of the head and neck squamous cell carcinoma (HNSCC). Despite significant advances in the understanding and treatment of cancer, prognosis of patients with LSCC has not improved recently. In the present study, we sought to understand better the genetic mechanisms underlying LSCC development. Thirty-two tumor samples were collected from patients undergoing surgical resection of LSCC. The samples were submitted to whole-genome cDNA microarray analysis aiming to identify genetic targets in LSCC...
September 22, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27639568/a-critical-evaluation-of-lymph-node-ratio-in-head-and-neck-cancer
#16
M de Ridder, C C M Marres, L E Smeele, M W M van den Brekel, M Hauptmann, A J M Balm, M L F van Velthuysen
In head and neck squamous cell carcinoma (HNSCC), the search for better prognostic factors beyond TNM-stage is ongoing. Lymph node ratio (LNR) (positive lymph nodes/total lymph nodes) is gaining interest in view of its potential prognostic significance. All HNSCC patients at the Netherlands Cancer Institute undergoing neck dissection for lymph node metastases in the neck region between 2002 and 2012 (n = 176) were included. Based on a protocol change in specimen processing, the cohort was subdivided in two distinct consecutive periods (pre and post 2007)...
December 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27639451/characterization-of-cervical-lymph-nodes-using-a-multi-parametric-and-multi-modal-approach-for-an-early-prediction-of-tumor-response-to-chemo-radiotherapy
#17
Elisa Scalco, Simona Marzi, Giuseppe Sanguineti, Antonello Vidiri, Giovanna Rizzo
PURPOSE: In the treatment of Head-and-Neck Squamous Cell Carcinoma (HNSCC), the early prediction of residual malignant lymph nodes (LNs) is currently required. Here, we investigated the potential of a multi-modal characterization (combination of CT, T2w-MRI and DW-MRI) at baseline and at mid-treatment, based on texture analysis (TA), for the early prediction of LNs response to chemo-radiotherapy (CRT). METHODS: 30 patients with pathologically confirmed HNSCC treated with CRT were considered...
September 14, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27622018/intra-cheek-immunization-as-a-novel-vaccination-route-for-therapeutic-vaccines-of-head-and-neck-squamous-cell-carcinomas-using-plasmo-virus-like-particles
#18
Rodney Macedo, Juliette Rochefort, Maude Guillot-Delost, Kae Tanaka, Aline Le Moignic, Clara Noizat, Claude Baillou, Véronique Mateo, Antoine F Carpentier, Eric Tartour, Chloé Bertolus, Bertrand Bellier, Géraldine Lescaille, François M Lemoine
Despite current therapy, head and neck squamous cell carcinomas (HNSCCs) arising from various mucosal sites of the upper aero-digestive tract frequently relapse in a loco-regional manner and have a poor prognosis. Our objective was to validate an innovative mucosal route of vaccination using plasmo virus-like particles (pVLPs) in a pre-clinical orthotopic model of HNSCCs. For this purpose, we used pVLP-E7, that are plasmid DNA encoding retroviral virus-like particles carrying a truncated E7 oncoprotein from HPV-16 as antigen model, to vaccinate mice bearing pre-established TC-1 tumors implanted into the buccal mucosa...
July 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27602151/evaluation-of-egfr-as-a-prognostic-and-diagnostic-marker-for-head-and-neck-squamous-cell-carcinoma-patients
#19
Hana Polanska, Martina Raudenska, Kristyna Hudcová, Jaromir Gumulec, Marketa Svobodova, Zbynek Heger, Michaela Fojtu, Hana Binkova, Zuzana Horakova, Rom Kostrica, Vojtech Adam, Rene Kizek, Michal Masarik
Approximately 90% of all head and neck tumors are squamous cell carcinomas. The overall survival of patients with head and neck squamous cell carcinoma (HNSCC) is low (≤50%). A non-invasive marker of disease progression is sorely required. The present study focused on the plasmatic levels of epidermal growth factor receptor (EGFR) in HNSCC patients (N=92) compared with healthy (N=29) and diabetic [type 2 diabetes mellitus (T2DM); N=26] controls. Enzyme-linked immunosorbent assay using antibodies against the extracellular region of EGFR (L25-S645) was performed...
September 2016: Oncology Letters
https://www.readbyqxmd.com/read/27595504/notch1-regulates-invasion-and-metastasis-of-head-and-neck-squamous-cell-carcinoma-by-inducing-emt-through-c-myc
#20
Naoya Inamura, Taichi Kimura, Lei Wang, Hiroko Yanagi, Masumi Tsuda, Mishie Tanino, Hiroshi Nishihara, Satoshi Fukuda, Shinya Tanaka
OBJECTIVE: As 50% of patients of head and neck squamous carcinoma (HNSCC) exhibit poor prognosis, the identification of new therapeutic targets is required. Recently, there have been several reports about the correlation between Notch1 and HNSCC, but the precise mechanism is still obscure. Therefore, in this study, we examined the involvement of Notch1 in HNSCC by using HNSCC cell lines and surgical specimens. METHODS: To investigate the role of Notch1 in HNSCC, we examined the effect of Notch inhibitor DAPT on cell growth, invasion, and tumorigenicity using five HNSCC cell lines in vitro and in vivo...
August 29, 2016: Auris, Nasus, Larynx
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