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https://www.readbyqxmd.com/read/29774993/-preliminary-study-on-the-expression-of-egfrv%C3%A2-and-cxcr4-in-head-and-neck-squamous-cell-carcinoma
#1
H D Zhang, S C Gong, Y Q Liu, S B He, Q X Zhang, M Y Si, Z K Yu
Objective: The aim of this study is to detect the expression of EGFRvⅢ and CXCR4 in HNSCC and to explore its possible mechanism. Method: We selected 60 cases of HNSCC from May 2013 to November 2016 in our hospital for surgical treatment, including 44 cases of laryngeal squamous cell carcinoma, 14 cases of hypopharyngeal squamous cell carcinoma, and 2 cases of nasal squamous cell carcinoma. pTNM staging according to AJCC 2010, Ⅲ stage 17 cases, Ⅳa stage 40 cases, and Ⅳb stage 3 cases; according to tumor differentiation degree: 13 cases of high differentiation, moderately differentiation in 31 cases, and 16 cases of low differentiated; primary tumor, positive lymph node metastasis as the experimental group, and 10 cases of adjacent tissues are taken as control (control group)...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29743718/expressional-analysis-of-disease-relevant-signalling-pathways-in-primary-tumours-and-metastasis-of-head-and-neck-cancers
#2
Dorothee Goesswein, Negusse Habtemichael, Aslihan Gerhold-Ay, Johanna Mazur, Désirée Wünsch, Shirley K Knauer, Julian Künzel, Christoph Matthias, Sebastian Strieth, Roland H Stauber
Head and neck squamous cell carcinoma (HNSCC) often metastasize to lymph nodes resulting in poor prognosis for patients. Unfortunately, the underlying molecular mechanisms contributing to tumour aggressiveness, recurrences, and metastasis are still not fully understood. However, such knowledge is key to identify biomarkers and drug targets to improve prognosis and treatments. Consequently, we performed genome-wide expression profiling of 15 primary HNSSCs compared to corresponding lymph node metastases and non-malignant tissue of the same patient...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29742291/pd-1-and-pd-l1-expression-in-hnscc-primary-cancer-and-related-lymph-node-metastasis-impact-on-clinical-outcome
#3
Sven Schneider, Lorenz Kadletz, Robert Wiebringhaus, Lukas Kenner, Edgar Selzer, Thorsten Füreder, Orsolya Rajky, Anna S Berghoff, Matthias Preusser, Gregor Heiduschka
AIMS: Expression profiles and clinical impact of programmed cell death ligand 1 (PD-L1) and programmed cell death 1 (PD-1) expressing tumour infiltrating lymphocytes (TILs) in head and neck squamous cell carcinoma (HNSCC) are not fully elucidated. This study evaluates expression patterns in primary HNSCC and related lymph node metastasis and impact on patients' clinical outcome. METHODS AND RESULTS: Immunohistochemical staining patterns of PD-L1 and PD-1 were evaluated in 129 specimens of primary HNSCC and 77 lymph node metastases...
May 9, 2018: Histopathology
https://www.readbyqxmd.com/read/29731551/evaluation-of-epidermal-growth-factor-receptor-expression-by-a-new-scoring-system-in-head-and-neck-squamous-cell-carcinoma-and-its-association-with-various-pathological-prognostic-factors
#4
Jyoti Verma, Vishal Dhingra, Sapan Srivastava, Vatsala Misra, Kachnar Varma, Shilpy Singh
Context: Squamous cell carcinoma is an aggressive epithelial malignancy of the upper aerodigestive tract comprising 90% of all head-and-neck squamous cell carcinoma (HNSCC). It is the sixth leading cancer worldwide, with approximately 600,000 cases reported annually. It is one of the most common cancers in India. Aims and Objective: Epidermal growth factor receptor (EGFR) being the most promising marker has potentially offered new methods to prognosticate and plays an essential role in early diagnosis and treatment apart from tumor, node and metastasis staging which has been used till now...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29693336/serum-cxcl12-but-not-cxcr4-is-associated-with-head-and-neck-squamous-cell-carcinomas
#5
Fatemeh Lavaee, Sahar Zare, Zahra Mojtahedi, Mahyar Malekzadeh, Abbas Ghaderi
Background: Squamous cell carcinoma (SCC) is the most frequent malignancy of the head and neck (HN) region. We here evaluated associations of stromal cell derived factor-1 (SDF-1or CXCL12) and its receptor, CXCR4, with HNSCCs. Materials and Methods: Sixty newly diagnosed HNSCC patients were enrolled in the patient group, and 28 healthy individuals in the control group. Plasma levels of CXCL12 and CXCR4 were measured using ELISA kits. Results: There was a significant difference in mean CXCL12, but not CXCR4, plasma levels between the patient and control groups (P=0...
April 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29674419/comparative-study-of-the-novel-rgd-motif-containing-itg%C3%AE-v%C3%AE-6-binding-peptides-sflap3-and-sfitgv6-for-diagnostic-application-in-hnscc
#6
Saskia Roesch, Thomas Lindner, Max Sauter, Anastasia Loktev, Paul Flechsig, Martin Müller, Walter Mier, Rolf Warta, Gerhard Dyckhoff, Christel Herold-Mende, Uwe Haberkorn, Annette Altmann
Alpha v beta 6 (αvβ6) integrin is overexpressed by several carcinomas, and thus considered as target for diagnostic imaging and anti-cancer therapies. Recently, we presented SFITGv6 as a novel potential tracer for imaging and targeted therapy of αvβ6 integin-positive carcinomas. Here, we analyzed affinity and specificity of five native αvβ6 integrin-specific binders in comparison to SFITGv6. Methods: Sunflower trypsin inhibitor (SFTI)-1-based peptides containing arginine-glycine-aspartic acid (RGD) motif-spanning octamers of fibronectin (SFFN1), tenascin C (SFTNC), vitronectin (SFVTN), and latency-associated peptides (LAP) 1 (SFLAP1), and 3 (SFLAP3) were synthesized and their binding potential to αvβ6 integrin-expressing head and neck squamous cell carcinoma (HNSCC) cell lines was evaluated...
April 19, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29667275/clinicopathological-significance-of-mir-26-mir-107-mir-125b-and-mir-203-in-head-and-neck-carcinomas
#7
Wilfredo Alejandro González-Arriagada, Pablo Olivero, Belén Rodríguez, Carlo Lozano-Burgos, Carine Ervolino de Oliveira, Ricardo D Coletta
OBJECTIVES: MicroRNAs play a role in the development and progression of head and neck squamous cell carcinomas (HNSCC). Our aim was to study the expression of miR-26, miR-107, miR-125b and miR-203 in primary HNSCC with and without lymph node metastasis and their clinicopathological significance. MATERIALS AND METHODS: The expression of microRNAs in primary HNSCC with lymph node metastasis (n=16), and their matched lymph node, as well as primary tumours without metastasis (n=16), were determined by quantitative RT-PCR, and analysed with clinicopathological features and survival...
April 18, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29661793/cell-free-plasma-dna-for-disease-stratification-and-prognosis-in-head-and-neck-cancer
#8
Markus A Schirmer, Julia Beck, Martin Leu, Michael Oellerich, Margret Rave-Fränk, Philip D Walson, Ekkehard Schütz, Martin Canis
BACKGROUND: Clinicians face many challenges in disease stratification and outcome prediction in head and neck squamous cancer cell (HNSCC) patients. Given the limitations of currently used clinical scoring, repetitive biopsies, and imaging techniques, liquid biopsy approaches may provide valuable additional diagnostic and prognostic information. METHODS: A noninterventional, single-center observational study was performed with clinical data and plasma samples from HNSCC patients...
April 16, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29596469/low-sox2-expression-marks-a-distinct-subset-of-adenoid-cystic-carcinoma-of-the-head-and-neck-and-is-associated-with-an-advanced-tumor-stage
#9
Julia Thierauf, Stephanie E Weissinger, Johannes A Veit, Annette Affolter, Natalia K Laureano, Dirk Beutner, Gregor Heiduschka, Lorenz Kadletz, Moritz Meyer, Alexander Quaas, Peter Plinkert, Thomas K Hoffmann, Jochen Hess
INTRODUCTION: The transcription factor SOX2 has been identified as a lineage survival oncogene in squamous cell carcinoma and copy number gain is a common event in several human malignancies including head and neck cancer. However, the regulation and function of SOX2 during carcinogenesis as well as its prognostic value appears to be highly context dependent. As an example, high SOX2 expression in lung squamous cell carcinoma (SCC) is related to a favorable prognosis, while it is associated with poor outcome in lung adenocarcinoma...
2018: PloS One
https://www.readbyqxmd.com/read/29582174/arterial-spin-labeling-perfusion-weighted-mr-imaging-correlation-of-tumor-blood-flow-with-pathological-degree-of-tumor-differentiation-clinical-stage-and-nodal-metastasis-of-head-and-neck-squamous-cell-carcinoma
#10
Ahmed Abdel Khalek Abdel Razek, Nadia Nada
PURPOSE: The prognostic parameters of head and neck squamous cell carcinoma (HNSCC) include the pathological degree of tumor differentiation, clinical staging, and presence of metastatic cervical lymph nodes. To correlate tumor blood flow (TBF) acquired from arterial spin labeling (ASL) perfusion-weighted MR imaging with pathological degree of tumor differentiation, clinical stage, and nodal metastasis of HNSCC. MATERIALS AND METHODS: Retrospective analysis of 43 patients (31 male, 12 female with a mean age of 65 years) with HNSCC that underwent ASL of head and neck and TBF of HNSCC was calculated...
May 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29577858/expression-and-prognostic-relevance-of-gage1-and-xage1-cancer-testis-antigens-in-head-and-neck-squamous-cell-carcinoma
#11
B T R Karia, F T Zamuner, V Carlin, C Z de Oliveira, A L Carvalho, A L Vettore
BACKGROUND: In the last decades, survival rates in Head and Neck squamous cell carcinoma (HNSCC) have not changed, with a five-year survival of only 50%. Thus, there is a great need for the identification of new molecular targets and development of novel therapeutic strategies. Cancer-testis antigens (CTAs) are expressed in various types of tumor but rarely in healthy normal tissues. Therefore, they appear as ideal targets for immunotherapy approaches, as well as, unique markers for cancer diagnosis/prognosis...
March 22, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29571791/utility-of-mri-with-morphologic-and-diffusion-weighted-imaging-in-the-detection-of-post-treatment-nodal-disease-in-head-and-neck-squamous-cell-carcinoma
#12
Pravin Mundada, Arthur Damien Varoquaux, Vincent Lenoir, Claudio de Vito, Nicolas Dulguerov, Angeliki Ailianou, Francesca Caparrotti, Minerva Becker
PURPOSE: To determine the diagnostic performance of morphologic MRI with diffusion weighted imaging (DWIMRI) for the detection of post-treatment lymph node (LN) recurrence of head and neck squamous cell carcinoma (HNSCC). METHODS: This retrospective study is based on 33 HNSCC patients who underwent DWIMRI with apparent diffusion coefficient (ADC) measurements for suspected post-treatment loco-regional failure. Two radiologists, blinded to clinical/histopathological data, analyzed MR images according to established morphologic criteria and measured ADC values by drawing regions of interest on each normal/abnormal looking lymph node (LN)...
April 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29491058/squamous-cell-carcinoma-antigen-encoding-genes-serpinb3-b4-as-potentially-useful-markers-for-the-stratification-of-hnscc-tumours
#13
Zuzana Saidak, Mony Chenda Morisse, Denis Chatelain, Chloé Sauzay, Aline Houessinon, Nelly Guilain, Marion Soyez, Bruno Chauffert, Stéphanie Dakpé, Antoine Galmiche
BACKGROUND/AIM: The squamous cell carcinoma antigen (SCCA), encoded by the genes SERPINB3/B4, is a tumour marker produced by head and neck squamous cell carcinoma (HNSCC). We aimed to examine SERPINB3/B4 mRNA levels and its clinical significance in the therapeutic context. MATERIALS AND METHODS: We retrieved mRNA expression levels, clinical, pathological and genomic data for 520 HNSCC from The Cancer Genome Atlas (TCGA). RESULTS: HNSCC tumours express high levels of SERPINB3/B4 mRNA...
March 2018: Anticancer Research
https://www.readbyqxmd.com/read/29486141/cd317-signature-in-head-and-neck-cancer-indicates-poor-prognosis
#14
L-L Yang, L Wu, G-T Yu, W-F Zhang, B Liu, Z-J Sun
Targeted therapy using monoclonal antibodies (mAbs) has emerged as a widely used form of immunotherapy in head and neck squamous cell carcinoma (HNSCC). Membrane-associated glycoprotein CD317 has been preferentially overexpressed by multiple myeloma cells, and its humanized mAb has been previously used in clinical trials. However, overexpression of CD317 in HNSCC and its correlation with tumor immunity is still uncertain. Here, the immunoreactivity of CD317 was detected in human HNSCC tissue microarrays, which contained 43 oral mucosa samples, 48 dysplasia samples, and 165 primary HNSCC...
February 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29456952/clinicopathological-significance-of-tumor-lymphatic-vessel-density-in-head-and-neck-squamous-cell-carcinoma
#15
Padam Parmar, Nisha Marwah, Sanjeev Parshad, Taruna Yadav, Ashima Batra, Rajeev Sen
Various studies have demonstrated that the lymphatic system is the additional route for solid tumor metastasis. Lymph nodes metastasis in Head and neck squamous cell carcinoma (HNSCC) is a major prognostic indicator for disease progression and a guide for therapeutic strategies. We conducted a study to compare intratumoral (IT) and peritumoral (PT) lymphatic vessel density (LVD) in HNSCC using lymphatic marker D2-40 and its correlation with lymph node metastasis, histological grading and other clinicopathological parameters...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29423108/cancer-immunogenomic-approach-to-neoantigen-discovery-in-a-checkpoint-blockade-responsive-murine-model-of-oral-cavity-squamous-cell-carcinoma
#16
Paul Zolkind, Dariusz Przybylski, Nemanja Marjanovic, Lan Nguyen, Tianxiang Lin, Tanner Johanns, Anton Alexandrov, Liye Zhou, Clint T Allen, Alexander P Miceli, Robert D Schreiber, Maxim Artyomov, Gavin P Dunn, Ravindra Uppaluri
Head and neck squamous cell carcinomas (HNSCC) are an ideal immunotherapy target due to their high mutation burden and frequent infiltration with lymphocytes. Preclinical models to investigate targeted and combination therapies as well as defining biomarkers to guide treatment represent an important need in the field. Immunogenomics approaches have illuminated the role of mutation-derived tumor neoantigens as potential biomarkers of response to checkpoint blockade as well as representing therapeutic vaccines...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29396680/detection-of-distant-metastases-in-head-and-neck-cancer-changing-landscape
#17
REVIEW
Remco de Bree, Asaf Senft, Andrés Coca-Pelaz, Luiz Kowalski, Fernando Lopez, William Mendenhall, Miquel Quer, Alessandra Rinaldo, Ashok R Shaha, Primož Strojan, Robert P Takes, Carl E Silver, C René Leemans, Alfio Ferlito
As head and neck squamous cell carcinoma (HNSCC) patients with distant metastases (DM) were generally treated only palliatively, the value of screening for DM was usually limited to attempts to avoid extensive locoregional treatment when DM were present pretreatment. Recently, the concept of treating oligometastases, e.g., by metastatectomy or stereotactic body radiotherapy, has been reintroduced for HNSCC and may cause a change in the treatment paradigm. Although whole body 18 F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) combined with computed tomography (CT; WB-FDG-PET/CT) is still the mainstay diagnostic technique, there is a growing body of evidence supporting implementation of whole body magnetic resonance imaging (WB-MRI) as an important diagnostic technique for screening for DM...
February 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29395434/selective-neck-dissection-in-surgically-treated-head-and-neck-squamous-cell-carcinoma-patients-with-a-clinically-positive-neck-systematic-review
#18
REVIEW
Juan P Rodrigo, Gianluigi Grilli, Jatin P Shah, Jesus E Medina, K Thomas Robbins, Robert P Takes, Marc Hamoir, Luiz P Kowalski, Carlos Suárez, Fernando López, Miquel Quer, Carsten C Boedeker, Remco de Bree, Hakan Coskun, Alessandra Rinaldo, Carl E Silver, Alfio Ferlito
Adequate treatment of lymph node metastases is essential for patients with head and neck squamous cell carcinoma (HNSCC). However, there is still no consensus on the optimal surgical treatment of the neck for patients with a clinically positive (cN+) neck. In this review, we analyzed current literature about the feasibility of selective neck dissection (SND) in surgically treated HNSCC patients with cN + neck using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. From the reviewed literature, it seems that SND is a valid option in patients with cN1 and selected cN2 neck disease (non-fixed nodes, absence of palpable metastases at level IV or V, or large volume ->3 cm-multiple lymph nodes at multiple levels)...
April 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29395313/myosin-1b-promotes-cell-proliferation-migration-and-invasion-in-cervical-cancer
#19
Han-Rong Zhang, Shu-Yu Lai, Li-Jun Huang, Zhen-Fei Zhang, Jie Liu, Si-Rong Zheng, Ke Ding, Xin Bai, Jue-Yu Zhou
OBJECTIVE: Recent evidence suggests an important role of Myosin 1b (Myo1b) in the progression of several cancers, including prostate cancer and head and neck squamous cell carcinoma (HNSCC). However, the contribution of Myo1b to cervical cancer (CC) remains elusive. METHODS: Quantitative reverse transcription polymerase chain reaction (qRT-PCR), immunohistochemistry and western blotting assays were used to confirm the expression of Myo1b in CC tissues compared with matched non-tumor tissues and CC cells, and analyze its clinical significance...
April 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29394461/prognostic-value-of-lymph-node-ratio-in-head-and-neck-squamous-cell-carcinoma
#20
REVIEW
Yoav P Talmi, Robert P Takes, Eran E Alon, Iain J Nixon, Fernando López, Remco de Bree, Juan P Rodrigo, Ashok R Shaha, Gyorgy B Halmos, Alessandra Rinaldo, Alfio Ferlito
BACKGROUND: Lymph node ratio (LNR) is increasingly reported as a potential prognostic tool. The purpose of this review was to analyze the available literature on the prognostic significance of LNR in head and neck squamous cell carcinoma (HNSCC). METHODS: A PubMed internet search was performed and articles meeting selection criteria were reviewed. RESULTS: Twenty-eight studies were identified in the literature dealing with the prognostic value of LNR...
May 2018: Head & Neck
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