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Lymph Node HNSCC

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https://www.readbyqxmd.com/read/29141306/-methods-and-advances-in-the-research-of-lymphatics-in-the-head-and-neck
#1
R Guo, J Tian, Y Jia, P F He, R X Jin, J Guo, B Q Wang
The lymphatic system plays an important role in human health and disease. In addition to a role in the immune response, the lymphatics can also serve as a pathway for cancer metastasis.Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers.In the case where the primary focus has been controlled, cervical lymph node metastasis is one of the most important factors affecting the prognosis of head and neck cancer.Thus, understanding the anatomy of the lymphatic system is of paramount importance in predicting cancer metastasis and to perform proper lymph node dissection in cancer patients...
November 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29124000/human-papillomavirus-associated-head-and-neck-squamous-cell-carcinoma-controversies-and-new-concepts
#2
REVIEW
Nuzhat Husain, Azfar Neyaz
High-risk human papillomavirus (HR-HPV) is a causative agent for an increasing subset of oropharyngeal squamous cell carcinoma. HPV 16 accounts for 90% of cases. The chance for malignant transformation due to infection with high-risk HPV is proportional to the expression of the viral oncogene products E6 and E7, which inactivate p53 and retinoblastoma (Rb) tumor suppressor functions. P16 is a surrogate marker of HPV associated HNSCC and 2+/3+ expression in more than 75% cells is diagnostic. Molecular demonstration of integrated virus by in situ hybridization is specific but has low sensitivity...
September 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/29113308/kdm4a-as-a-prognostic-marker-of-oral-squamous-cell-carcinoma-evidence-from-tissue-microarray-studies-in-a-multicenter-cohort
#3
Xin Jin, Hao Xu, Xingyu Wu, Taiwen Li, Jing Li, Yu Zhou, Hongxia Dan, Lu Jiang, Xin Zeng, Ping Ji, Qianming Chen
Purpose: Previous studies have identified histone demethylase KDM4A to be a key epigenetic priming factor for the invasive squamous cell carcinoma growth and metastasis. The purpose of this study was to examine KDM4A as an independent prognostic marker in oral squamous cell carcinoma, using multicenter tissue microarrays. Results: The expression of KDM4A was significantly correlated with lymph node metastasis and TNM stage. KDM4A overexpression was associated with poor overall survival, and it was found to be a statistically significant independent predictor of all-cause mortality...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29107665/eps8-expression-is-significantly-lower-in-p16-head-and-neck-squamous-cell-carcinomas-hnscc-compared-to-p16-hnscc
#4
Elham Nasri, Lisa B Wiesen, Jacquelyn A Knapik, Kristianna M Fredenburg
In vitro head and neck cancer studies have demonstrated that epidermal growth factor receptor kinase substrate 8 (Eps8) overexpression contributes to squamous carcinogenesis. Oral squamous cell carcinoma studies have correlated Eps8 expression with metastatic disease and poor prognosis. Head and neck squamous cell carcinoma (HNSCC) studies comparing its expression by anatomic site or in in vivo regional metastases have not been performed. In this study, we compared Eps8 expression in HNSCCs arising in the oral cavity (OCSCC) and oropharynx (OPSCC) along with their corresponding regional lymph nodes (LNs) metastases...
October 28, 2017: Human Pathology
https://www.readbyqxmd.com/read/29103745/assessment-of-adjuvant-therapy-in-resected-head-and-neck-cancer-with-high-risk-features
#5
Gaurav S Ajmani, Cheryl C Nocon, Chi-Hsiung Wang, Mihir K Bhayani
OBJECTIVES: Subgroup analysis from two randomized trials showed a survival benefit for adjuvant chemoradiation (CRT) over radiation alone (RT) in patients with extracapsular spread (ECS) of involved lymph nodes and/or positive margins (PM) in resected head and neck cancer (HNSCC). However, results were not analyzed separately for patients with ECS or PM and were not stratified by tumor subsite/HPV status. We therefore sought to determine whether adjuvant CRT is associated with a survival benefit, separately among patients with ECS or PM and stratified by subsite/HPV status...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29100314/genes-encoding-neuropeptide-receptors-are-epigenetic-markers-in-patients-with-head-and-neck-cancer-a-site-specific-analysis
#6
Kiyoshi Misawa, Atsushi Imai, Daiki Mochizuki, Yuki Misawa, Shiori Endo, Seiji Hosokawa, Ryuji Ishikawa, Masato Mima, Kazuya Shinmura, Takeharu Kanazawa, Hiroyuki Mineta
Staging and pathological grading systems are useful but imperfect predictors of recurrence in head and neck squamous cell carcinoma (HNSCC). To identify potential prognostic markers, we examined the methylation status of eight neuropeptide receptor gene promoters in 231 head and neck squamous cell carcinomas. The NPFFR1, NPFFR2, HCRTR1, HCRTR2, NPY1R, NPY2R, NPY4R, and NPY5R promoters were methylated in 80.5%, 79.2%, 67.1%, 73.2%, 35.1%, 36.4%, 38.5%, and 35.9% of the samples, respectively. In a multivariate Cox proportional hazards analysis, the odds ratio for recurrence was 2...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29068587/the-notch-signaling-pathway-in-head-and-neck-squamous-cell-carcinoma-a-meta-analysis
#7
REVIEW
Yu-Yue Zhao, Guang-Tao Yu, Ting Xiao, Jian Hu
BACKGROUND: The Notch signaling pathway has been associated with the regulation of self-renewal capacity, cell cycle exit, and survival. However, the relationship between the Notch signaling pathway and HNSCC remains controversial. OBJECTIVES: A meta-analysis was conducted to evaluate the role of Notch signaling pathway in HNSCC. MATERIAL AND METHODS: Relevant studies published until March 31, 2015 were identified by searching the PubMed, EMBASE and Ovid database...
August 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29035450/imbalance-between-matrix-metalloproteinases-and-tissue-inhibitors-of-metalloproteinases-promotes-invasion-and-metastasis-of-head-and-neck-squamous-cell-carcinoma
#8
Adina E Stanciu, Adina Zamfir-Chiru-Anton, Marcel M Stanciu, Cristian R Popescu, Dan C Gheorghe
BACKGROUND: The balance between collagenolysis and its inhibition is critical during extracellular matrix remodeling in head and neck squamous cell carcinoma (HNSCC). An imbalance between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) plays a critical role in the development of tumor cell invasion and metastasis. The purpose of the study was to determine MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in the sera of patients with HNSCC in relation to clinicopathological parameters...
October 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28983555/measuring-institutional-quality-in-head-and-neck-surgery-using-hospital-level-data-negative-margin-rates-and-neck-dissection-yield
#9
David W Schoppy, Kim F Rhoads, Yifei Ma, Michelle M Chen, Brian Nussenbaum, Ryan K Orosco, Eben L Rosenthal, Vasu Divi
Importance: Negative margins and lymph node yields (LNY) of 18 or more from neck dissections in patients with head and neck squamous cell carcinomas (HNSCC) have been associated with improved patient survival. It is unclear whether these metrics can be used to identify hospitals with improved outcomes. Objective: To determine whether 2 patient-level metrics would predict outcomes at the hospital level. Design, Setting, and Participants: A retrospective review of records from the National Cancer Database (NCDB) was used to identify patients who underwent primary surgery and concurrent neck dissection for HNSCC between 2004 and 2013...
November 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28952562/human-papillomavirus-investigation-in-head-and-neck-squamous-cell-carcinoma-initial-report-from-the-low-risk-hpv-types-associations
#10
Mohammad Hadi Karbalaie Niya, Fahimeh Safarnezhad Tameshkel, Mahshid Panahi, Farah Bokharaei Salim, Seyed Hamid Reza Monavari, Hossein Keyvani
Background: Head and neck squamous cell carcinomas (HNSCC) are a major health issue in many parts of the world. Recently, attention has focused on the human papilloma virus (HPV) as a potential causative agent for HNSCC. This study aimed to survey HPV occurrence in HNSCCs as part of a comprehensive molecular epidemiology approach. Methods: In this retrospective study, patients were recruited from hospitals affiliated to the Iran University of Medical Sciences, Tehran, Iran. Formalin-fixed paraffin-embedded (FFPE) blocks were subjected to DNA isolation by QIAamp® DNA FFPE Tissue Kit and nested PCR, HPV-16 specific conventional PCR, and extra INNO-LiPA HPV genotyping assays were subsequently performed...
September 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28938850/cd73-expression-in-lymph-node-metastases-in-patients-with-head-and-neck-cancer
#11
Magis Mandapathil, Mehtap Boduc, Christoph Netzer, Christian Güldner, Marion Roessler, Ute Wallicek-Dworschak, Evelyn Jahns, Boris Stuck
INTRODUCTION: CD73 is an enzyme crucial in the metabolism of immunosuppressive adenosine. In cancer, it has various functions including tumor growth and metastases. Squamous cell carcinoma of the head and neck has an overall poor prognosis, also due to early spread of metastatic cells. MATERIALS AND METHODS: Tumor and lymph node specimens of 65 patients with HNSCC were subjected to immunohistochemical and H-score analysis of CD73 expression. Demographics, diagnoses, histopathology and subsequent outcome were analyzed...
September 22, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28919248/safety-of-differential-radiation-dosing-in-lymph-node-positive-necks-treated-with-imrt
#12
Stephen Sozio, Zorimar Rivera-Núñez, Omar Mahmoud, Sung Kim
PURPOSE: When treating head and neck squamous cell carcinoma (HNSCC) with intensity modulated radiation therapy (IMRT), it is common to use several dose levels for a lymph node positive neck: full dose (66-70 Gy) to gross cancer, intermediate dose (59-63 Gy) to higher risk neck regions, and standard dose (50-54 Gy) to lower risk neck regions. There is no consensus regarding how much of the neck should receive intermediate versus standard dose, however. METHODS AND MATERIALS: HNSCC patients treated with IMRT were identified from 2 academic medical centers between 2004 and 2016...
July 19, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28915554/resistance-to-ctla-4-checkpoint-inhibition-reversed-through-selective-elimination-of-granulocytic-myeloid-cells
#13
Paul E Clavijo, Ellen C Moore, Jianhong Chen, Ruth J Davis, Jay Friedman, Young Kim, Carter Van Waes, Zhong Chen, Clint T Allen
PURPOSE: Local immunosuppression remains a critical problem that limits clinically meaningful response to checkpoint inhibition in patients with head and neck cancer. Here, we assessed the impact of MDSC elimination on responses to CTLA-4 checkpoint inhibition. EXPERIMENTAL DESIGN: Murine syngeneic carcinoma immune infiltrates were characterized by flow cytometry. Granulocytic MDSCs (gMDSCs) were depleted and T-lymphocyte antigen-specific responses were measured...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28905170/-follow-up-ultrasound-of-head-and-neck-cancer
#14
J Künzel, A Bozzato, S Strieth
In Germany high-resolution sonography using the color duplex mode in addition to computed tomography (CT) is a well-established and proven method in the context of restaging after primary therapy of head and neck squamous cell cancer (HNSCC). There are no international evidence-based restaging guidelines. Decisions concerning neck dissection (ND) after primary radiochemotherapy (RCT) are often individually derived in the respective tumor conferences and are therefore subject to variance. Compared to the UK or USA, in Germany there is a high level of expertise in the use of ultrasound in combination with CT for the routine restaging of HNSCC after RCT...
November 2017: HNO
https://www.readbyqxmd.com/read/28902347/measuring-the-response-of-human-head-and-neck-squamous-cell-carcinoma-to-irradiation-in-a-microfluidic-model-allowing-customized-therapy
#15
Ramsah Cheah, Rishi Srivastava, Nicholas D Stafford, Andrew W Beavis, Victoria Green, John Greenman
Radiotherapy is the standard treatment for head and neck squamous cell carcinoma (HNSCC), however, radioresistance remains a major clinical problem despite significant improvements in treatment protocols. Therapeutic outcome could potentially be improved if a patient's tumour response to irradiation could be predicted ex vivo before clinical application. The present study employed a bespoke microfluidic device to maintain HNSCC tissue whilst subjecting it to external beam irradiation and measured the responses using a panel of cell death and proliferation markers...
October 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28891398/geometric-analysis-of-loco-regional-recurrences-in-relation-to-pre-treatment-hypoxia-in-patients-with-head-and-neck-cancer
#16
Simon Boeke, Daniela Thorwarth, David Mönnich, Christina Pfannenberg, Gerald Reischl, Christian La Fougère, Konstantin Nikolaou, Paul-Stefan Mauz, Frank Paulsen, Daniel Zips, Stefan Welz
INTRODUCTION: A previous pattern-of-failure study has suggested that up to 50% of the loco-regional failures (LRF) in head and neck squamous cell carcinoma (HNSCC) occur outside the initial hypoxic volume determined by [(18)F]-fluoromisonidazole-PET ([(18)F]-FMISO-PET). The aim of the present analysis was to correlate spatial patterns of failure with respect to the pretherapeutic dynamic [(18)F]-FMISO-PET/CT in HNSCC after radiochemotherapy (RCT). MATERIAL AND METHODS: Within a running phase 2 trial using [(18)F]-FMISO-PET imaging prior to RCT in HNSCC patients (n = 54), we have observed so far 11 LRF with a minimum follow-up of 12 months...
September 11, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28855542/microbial-communities-associated-with-primary-and-metastatic-head-and-neck-squamous-cell-carcinoma-a-high-fusobacterial-and-low-streptococcal-signature
#17
Jae M Shin, Ting Luo, Pachiyappan Kamarajan, J Christopher Fenno, Alexander H Rickard, Yvonne L Kapila
Given the potential relationship between head and neck squamous cell carcinoma (HNSCC) and microbial dysbiosis, we profiled the microbiome within healthy normal and tumorous (primary and metastatic) human tissues from the oral cavity, larynx-pharynx, and lymph nodes using 16S rRNA sequencing. Alpha and beta diversity analyses revealed that normal tissues had the greatest richness in community diversity, while the metastatic populations were most closely related to one another. Compared to the normal, the microbiota associated with tumors supported altered abundances in the phyla Fusobacteria, Firmicutes, Actinobacteria and Proteobacteria...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28831179/global-proteomics-based-identification-and-validation-of-thymosin-beta-4-x-linked-as-a-prognostic-marker-for-head-and-neck-squamous-cell-carcinoma
#18
Li-Hsing Chi, Wei-Min Chang, Yu-Chan Chang, Yung-Chieh Chan, Chia-Chen Tai, Kam-Wing Leung, Chi-Long Chen, Alexander Th Wu, Tsung-Ching Lai, Yu-Chuan Jack Li, Michael Hsiao
Head and neck squamous cell carcinoma (HNSCC) represents a major health concern worldwide. We applied the matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) to analyze paired normal (N) and tumor (T) samples from head and neck squamous cell carcinoma as well as liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis in HNSCC cell lines to identify tumor-associated biomarkers. Our results showed a number of proteins found to be over-expressed in HNSCC. We identified thymosin beta-4 X-linked (TMSB4X) is one of the most significant candidate biomarkers...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28771750/comprehensive-t-cell-immunophenotyping-and-next-generation-sequencing-of-human-papillomavirus-hpv-positive-and-hpv-negative-head-and-neck-squamous-cell-carcinomas
#19
Kate Poropatich, Joel Fontanarosa, Suchitra Swaminathan, Dave Dittmann, Siqi Chen, Sandeep Samant, Bin Zhang
The success of programmed cell death 1 (PD-1) inhibition in achieving a clinical response in a subset of head and neck squamous cell carcinoma (HNSCC) patients emphasizes the need to better understand the immunobiology of HNSCC. Immunophenotyping was performed for 30 HCSCC patients [16 human papillomavirus (HPV)-positive; 14 HPV-negative] on matched tissue from the primary tumour site, locally metastatic cervical lymph nodes (LNs), uninvolved local cervical LNs, and peripheral blood. CD4(+) and CD8(+) T-cell lymphocytes obtained from tissue were analysed for expression levels of the inhibitory receptors PD-1, TIM-3 and CTLA-4...
November 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28756006/upfront-vs-no-upfront-neck-dissection-in-primary-head-and-neck-cancer-radio-chemo-therapy-tumor-control-and-late-toxicity
#20
Daan Nevens, Fréderic Duprez, Katrien Bonte, Philippe Deron, Wouter Huvenne, Annouschka Laenen, Wilfried De Neve, Sandra Nuyts
PURPOSE/OBJECTIVE: The benefit of upfront neck dissection (ND) in locally advanced head and neck squamous cell carcinoma (HNSCC) treated with primary (chemo-) radiotherapy (R(C)T) is debated. Therefore, we retrospectively compared disease control and toxicity between patients who were treated with and without upfront ND followed by R(C)T. MATERIAL/METHODS: Two-hundred sixty-four consecutive patients with HNSCC without distant metastases at diagnosis and with lymph node stage N2-N3 were included in 2 centers...
August 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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