keyword
https://read.qxmd.com/read/38367702/ccdc71l-as-a-novel-prognostic-marker-and-immunotherapy-target-via-lipid-metabolism-in-head-and-neck-squamous-cell-carcinoma
#21
JOURNAL ARTICLE
Yu Zhang, Huifang Tang, Minghui Zi, Zhiyong Zhang, Qi Gao, Songbo Tian
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is the sixth most widespread cancer globally with high rate and poor prognosis. Coiled-coil domain containing 71 like (CCDC71L) exerts an important role in cellular lipid metabolic process. However, its function in HNSCC remains unclear. To this end, we examined the CCDC71L implications for prognosis and tumor microenvironment in HNSCC. MATERIALS AND METHODS: First, CCDC71L expression was explored through The Cancer Genome Atlas (TCGA), Human Protein Atlas (HPA), the Gene Expression Profiling Interactive Analysis 2 (GEPIA2), Clinical Proteomic Tumor Analysis Consortium (CPTAC) and the Gene Expression Omnibus (GEO) databases...
February 15, 2024: Journal of Stomatology, Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38363001/transcriptomic-analysis-of-porphyromonas-gingivalis-infected-head-and-neck-cancer-cells-identification-of-plau-as-a-candidate-prognostic-biomarker
#22
JOURNAL ARTICLE
Masakazu Hamada, Hiroaki Inaba, Kyoko Nishiyama, Sho Yoshida, Yoshiaki Yura, Michiyo Matsumoto-Nakano, Narikazu Uzawa
Periodontal disease is a risk factor for head and neck squamous cell carcinoma (HNSCC), and Porphyromonas gingivalis, a major periodontal pathogen, has been identified as a specific and potentially independent microbial factor that increases the risk of cancer mortality. Gene expression in HNSCC due to P. gingivalis infection and how changes in gene expression affect the prognosis of HNSCC patients are not clarified. When P. gingivalis was cultured with HNSCC cells, it efficiently adhered to these cells and enhanced their invasive ability...
February 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38353363/neuronal-cfl1-upregulation-in-head-and-neck-squamous-cell-carcinoma-enhances-tumor-nerve-crosstalk-and-promotes-tumor-growth
#23
JOURNAL ARTICLE
Ruoyan Liu, Chunli Wang, Zhonghao Sun, Xiaotian Shi, Ze Zhang, Jingtao Luo
Head and neck squamous cell carcinoma (HNSCC) is a prevalent cancer type, marked by a pronounced nerve density within the tumor microenvironment and a high rate of perineural invasion (PNI). Growing evidence suggests that the nervous system plays a vital role in HNSCC progression. Yet, the mechanisms governing cancer-nerve interactions remain largely elusive. Our research revealed that cofilin-1 (CFL1) is significantly overexpressed in HNSCC and correlates with both PNI and unfavorable prognosis. Utilizing multiplex fluorescent immunohistochemistry, we have localized CFL1 chiefly to the nerves adjacent to tumor sites...
February 14, 2024: Molecular Carcinogenesis
https://read.qxmd.com/read/38347320/an-angiogenesis-associated-gene-based-signature-predicting-prognosis-and-immunotherapy-efficacy-of-head-and-neck-squamous-cell-carcinoma-patients
#24
JOURNAL ARTICLE
Bangjie Chen, Yanxun Han, Shuyan Sheng, Jianyi Deng, Emely Vasquez, Vicky Yau, Muzi Meng, Chenyu Sun, Tao Wang, Yu Wang, Mengfei Sheng, Tiangang Wu, Xinyi Wang, Yuchen Liu, Ning Lin, Lei Zhang, Wei Shao
OBJECTIVES: To develop a model that can assist in the diagnosis and prediction of prognosis for head and neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: Data from TCGA and GEO databases were used to generate normalized gene expression data. Consensus Cluster Plus was used for cluster analysis and the relationship between angiogenesis-associated gene (AAG) expression patterns, clinical characteristics and survival was examined. Support vector machine (SVM) and least absolute shrinkage and selection operator (LASSO) analyzes and multiple logistic regression analyzes were performed to determine the diagnostic model, and a prognostic nomogram was constructed using univariate and multivariate Cox regression analyses...
February 12, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38342749/altered-expression-of-gls2-indicates-a-poor-prognosis-and-correlates-with-clinicopathological-features-of-oral-squamous-cell-carcinoma
#25
JOURNAL ARTICLE
B Kannan, C Pandi, A Pandi, V P Jayaseelan, S Murugan M, P Arumugam
Glutamine metabolism, governed by enzymes including glutaminase (GLS1 and GLS2), has a pivotal role in cancer progression. The objective of this study was to determine whether GLS2 transcription levels are associated with oral squamous cell carcinoma (OSCC) when compared to matched adjacent normal tissues. Primary tumour and adjacent normal tissues were collected from 51 OSCC patients, and GLS2 mRNA expression analysis was conducted using real-time qPCR. Additionally, The Cancer Genome Atlas-Head and Neck Squamous Cell Carcinoma (TCGA-HNSCC) dataset was utilized to examine GLS2 expression in relation to clinicopathological features, the prognosis, and tumour immune cell infiltration...
February 10, 2024: International Journal of Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38335389/hypoxia-derived-molecular-subtype-and-gene-signature-characterize-prognoses-and-therapeutic-responses-in-head-and-neck-squamous-cell-carcinoma
#26
JOURNAL ARTICLE
Jianjun Zou, Shidong Chu, Huaien Zhou, Yiyun Zhang
Intratumoral hypoxia is widely associated with the development of malignancy, treatment resistance, and worse prognoses. This study aims to investigate the role of hypoxia-related genes (HRG) in the immune landscape, treatment response, and prognosis of head and neck squamous cell carcinoma (HNSCC). The transcriptome and clinical data of HNSCC were downloaded from TCGA and GEO databases, and HNSCC molecular subtypes were identified using non-negative matrix factorization (NMF) clustering. Prognostic models were constructed using univariate, Lasso, and multivariate Cox regression analyses...
February 9, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38310463/development-of-chromatin-regulator-related-molecular-subtypes-and-a-signature-to-predict-prognosis-and-immunotherapeutic-response-in-head-and-neck-squamous-cell-carcinoma
#27
JOURNAL ARTICLE
Juntao Huang, Ziqian Xu, ZhenZhen Wang, Chongchang Zhou, Yi Shen
BACKGROUND: Chromatin regulators (CRs) serve as indispensable factors in tumor biological processes by influencing tumorigenesis and the immune microenvironment and have been identified in head and neck squamous cell carcinoma (HNSCC). Hence, CR-related genes (CRRGs) are considered potential biomarkers for predicting prognosis and immune infiltration in HNSCC. In this study, we established a novel signature for predicting the prognosis and immunotherapeutic response of HSNCC. METHODS: A total of 870 CRRGs were obtained according to previous studies...
January 4, 2024: Current Cancer Drug Targets
https://read.qxmd.com/read/38303833/association-of-higher-transient-receptor-potential-melastatin-8-expression-with-higher-tumor-histologic-grades-lymph-node-metastasis-risk-factors-and-worse-survival-in-patients-with-head-and-neck-squamous-cell-carcinoma
#28
JOURNAL ARTICLE
Nan-Chin Lin, Thanh-Hien Vu Nguyen, Yin-Hwa Shih, Yi-Hung Chen, Yen-Wen Shen, Kuo-Chou Chiu, Shih-Min Hsia, Tzong-Ming Shieh
BACKGROUND/PURPOSE: Transient receptor potential melastatin 8 (TRPM8), a thermosensitive ion channel known for its role in cold sensation and menthol response, has emerged as a potential regulator in various cancers. This study aimed to investigate expression trends of TRPM8 in head and neck squamous cell carcinoma (HNSCC) cases and oral squamous cell carcinoma (OSCC) cell lines and its association with clinicopathological features. MATERIALS AND METHODS: The noncancerous matched tissues and HNSCC paired tissue samples from 84 HNSCC patients were utilized to evaluate the association of TRPM8 with HNSCC clinicopathological features...
January 2024: Journal of Dental Sciences
https://read.qxmd.com/read/38279934/association-of-cuproptosis-related-signature-with-the-prognosis-of-patients-with-head-and-neck-squamous-cell-carcinoma
#29
JOURNAL ARTICLE
Yunshan Li, Caidie Sun, Feihan Gu, Jiayuan Yue, Xu Huang, Bin Yuan, Yuanyin Wang, Ran Chen
Patients with head and neck squamous cell carcinoma (HNSCC) have a poor prognosis because of their high recurrence and metastasis rates. Cuproptosis is a novel type of copper-dependent cell death that differs from apoptosis, necroptosis, and cytosolic scorch death. We designed and validated an individualized cuproptosis-related gene (CRG) signature for risk evaluation and prognostic prediction in HNSCC patients. Ninety differentially expressed CRGs were found in HNSCC. Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway analyses were performed to investigate the functional involvement of CRGs in the Cancer Genome Atlas (TCGA) HNSCC cohort...
January 27, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38279245/an-esr1-related-gene-signature-identifies-head-and-neck-squamous-cell-carcinoma-with-imputed-susceptibility-to-endocrine-therapy
#30
JOURNAL ARTICLE
Firas Almouhanna, Jochen Hess
Head and neck squamous cell carcinoma (HNSCC) is associated with high morbidity and mortality. New personalized treatment strategies represent an unmet medical need to improve the overall survival and the quality of life of patients, which are often limited by the toxicity of established multimodal treatment protocols. Several studies have reported an increased expression of the estrogen receptor 1 (ESR1) in HNSCC, but its potential role in the disease outcome of these tumors remains elusive. Using an integrative analysis of multiomics and clinical data from The Cancer Genome Atlas (TCGA)-HNSC, we established a prognostic risk model based on an ESR1-related 25-gene set...
January 19, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38263290/cyclic-increase-in-the-adamts1-l1cam-egfr-axis-promotes-the-emt-and-cervical-lymph-node-metastasis-of-oral-squamous-cell-carcinoma
#31
JOURNAL ARTICLE
Ming-Hsien Chien, Yi-Chieh Yang, Kuo-Hao Ho, Yi-Fang Ding, Li-Hsin Chen, Wen-Kuan Chiu, Ji-Qing Chen, Min-Che Tung, Michael Hsiao, Wei-Jiunn Lee
The matrix metalloprotease A disintegrin and metalloprotease with thrombospondin motifs 1 (ADAMTS1) was reported to be involved in tumor progression in several cancer types, but its contributions appear discrepant. At present, the role of ADAMTS1 in oral squamous cell carcinoma (SCC; OSCC) remains unclear. Herein, The Cancer Genome Atlas (TCGA) database showed that ADAMTS1 transcripts were downregulated in head and neck SCC (HNSCC) tissues compared to normal tissues, but ADAMTS1 levels were correlated with poorer prognoses of HNSCC patients...
January 23, 2024: Cell Death & Disease
https://read.qxmd.com/read/38259392/exploring-the-expression-of-bcas3-in-head-and-neck-squamous-cell-carcinoma-and-its-association-with-prognosis
#32
JOURNAL ARTICLE
Devanand Challa, Chandra Pandi, Balachander Kannan, Vijayashree J Priyadharsini, Paramasivam Arumugam
Background Head and neck squamous cell carcinoma (HNSCC) is a prominent global cancer that manifests across diverse sites such as the oral cavity, oropharynx, and larynx. Human papillomavirus (HPV) infection and genetic alterations contribute to HNSCC development. Objective To investigate the complex role of breast carcinoma amplified sequence (BCAS3) in HNSCC pathogenesis. Methods We used multiple databases to analyze BCAS3 expression in HNSCC using The Cancer Genome Atlas-Head-Neck Squamous Cell Carcinoma (TCGA-HNSC) dataset and validated it in oral squamous cell carcinoma (OSCC) using reverse transcription-quantitative polymerase chain reaction (RT-qPCR)...
December 2023: Curēus
https://read.qxmd.com/read/38254798/nad-metabolism-related-gene-profile-can-be-a-relevant-source-of-squamous-cell-carcinoma-biomarkers
#33
JOURNAL ARTICLE
Ylenia Aura Minafò, Dario Antonini, Elena Dellambra
Poor survival rates of squamous cell carcinomas (SCCs) are associated with high recurrence, metastasis, and late diagnosis, due in part to a limited number of reliable biomarkers. Thus, the identification of signatures improving the diagnosis of different SCC types is mandatory. Considering the relevant role of NAD+ metabolism in SCC chemoprevention and therapy, the study aimed at identifying new biomarkers based on NAD+ metabolism-related gene (NMRG) expression. Gene expression of 18 NMRGs and clinical-pathological information for patients with head and neck SCC (HNSCC), lung SCC (LuSCC), and cervix SCC (CeSCC) from The Cancer Genome Atlas (TCGA) were analyzed by several bioinformatic tools...
January 11, 2024: Cancers
https://read.qxmd.com/read/38252495/cxc-ligand-13-orchestrates-an-immunoactive-microenvironment-and-enhances-immunotherapy-response-in-head-and-neck-squamous-cell-carcinoma
#34
JOURNAL ARTICLE
Xiaohu Lin, Xiaomei Zhao, Yiming Chen, Rong Yang, Zhenlin Dai, Wei Li, Chengzhong Lin, Wei Cao
Objectives : This study aims to systematically explore the role of chemokine CXC ligand 13 (CXCL13) in head and neck squamous cell carcinoma (HNSCC). Methods : The Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) databases provided the RNA-seq data for cancer and normal tissues, respectively. Gene set enrichment analysis was applied to search the cancer hallmarks associated with CXCL13 expression. TIMER2.0 was the main platform used to investigate the immune cell infiltration related to CXCL13...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38246983/development-and-validation-of-a-pathomics-model-for-predicting-cxcl8-expression-and-prognosis-with-machine-learning-in-head-and-neck-cancer
#35
JOURNAL ARTICLE
Weihua Wang, Suyu Ruan, Yuhang Xie, Shengjian Fang, Junxian Yang, Xueyan Li, Yu Zhang
PURPOSE: It is imperative to investigate a method to indicate prognosis and to seek new biological markers for personalized medicine for head and neck squamous cell carcinoma (HNSCC) patients. Pathomics based on quantitative medical imaging analysis has emerged lately. CXCL8, a crucial inflammatory cytokine, is reflected in overall survival (OS). This study aimed to explore associations of the CXCL8 mRNA expression with pathom ics features and investigate the underlying biology of CXCL8...
January 22, 2024: Clinical and Experimental Otorhinolaryngology
https://read.qxmd.com/read/38246919/wnt7a-promotes-tumorigenesis-of-head-and-neck-squamous-cell-carcinoma-via-activating-fzd7-jak1-stat3-signaling
#36
JOURNAL ARTICLE
Qingling Huang, Yi Xiao, Ting Lan, Youguang Lu, Li Huang, Dali Zheng
Wnt signaling are critical pathway involved in organ development, tumorigenesis, and cancer progression. WNT7A, a member of the Wnt family, remains poorly understood in terms of its role and the underlying molecular mechanisms it entails in head and neck squamous cell carcinoma (HNSCC). According to the Cancer Genome Atlas (TCGA), transcriptome sequencing data of HNSCC, the expression level of WNT7A in tumors was found to be higher than in adjacent normal tissues, which was validated using Real-time RT-PCR and immunohistochemistry...
January 22, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38244579/development-and-validation-of-glycosyltransferase-related-gene-for-the-diagnosis-and-prognosis-of-head-and-neck-squamous-cell-carcinoma
#37
JOURNAL ARTICLE
Miao He, Li Wang, Zihan Yue, Chunbo Feng, Guosheng Dai, Jinsong Jiang, Hui Huang, Qingjun Ji, Minglang Zhou, Dapeng Li, Wei Chai
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous cancer characterized by difficulties in early diagnosis and outcome prediction. Aberrant glycosylated structures produced by the aberrant expression of glycosyltransferases are prevalent in HNSCC. In this study, we aim to construct glycosyltransferase-related gene signatures with diagnostic and prognostic value to better stratify patients with HNSCC and improve their diagnosis and prognosis. METHODS: Bioinformatic tools were used to process data of patients with HNSCC from The Cancer Genome Atlas (TCGA) database...
January 19, 2024: Aging
https://read.qxmd.com/read/38237211/multi-omics-comprehensive-analyses-of-programmed-cell-death-patterns-to-regulate-the-immune-characteristics-of-head-and-neck-squamous-cell-carcinoma
#38
JOURNAL ARTICLE
Yi Jin, Siwei Huang, Hongyu Zhou, Zhanwang Wang, Yonghong Zhou
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous cancer with high morbidity and mortality. Triggering the programmed cell death (PCD) to enhance the anti-tumor therapies is being applied in multiple cancers. However, the limited understanding of genetic heterogeneity in HNSCC severely hampers the clinical efficacy. We systematically analyzed 14 types of PCD in HNSCC from The Cancer Genome Atlas (TCGA). We utilized ssGSEA to calculate the PCD scores and classify patients into two clusters. Subsequently, we displayed the genomic alteration landscape to unravel the significant differences in copy number alterations and gene mutations...
January 17, 2024: Translational Oncology
https://read.qxmd.com/read/38236481/super-enhancer-loci-of-egfr-regulate-egfr-variant-8-through-enhancer-rna-and-strongly-associate-with-survival-in-hnsccs
#39
JOURNAL ARTICLE
Sundaram Reddy Chakkarappan, Karuppiah Vijayamuthuramalingam Umadharshini, Shankar Dhamodharan, Mathew Maria Rose, Govindasamy Gopu, Avaniyapuram Kannan Murugan, Ituro Inoue, Arasambattu Kannan Munirajan
Epidermal growth factor receptor (EGFR) has been shown to be overexpressed in human cancers due to mutation, amplification, and epigenetic hyperactivity, which leads to deregulated transcriptional mechanism. Among the eight different EGFR isoforms, the mechanism of regulation of full-length variant 1 is well-known, no studies have examined the function & factors regulating the expression of variant 8. This study aimed to understand the function of EGFR super-enhancer loci and its associated transcription factors regulating the expression of EGFR variant 8...
January 18, 2024: Molecular Genetics and Genomics: MGG
https://read.qxmd.com/read/38218022/uncovering-immune-checkpoint-heterogeneity-in-oral-squamous-cell-carcinoma-using-single-cell-rna-sequencing-data-highlights-three-subgroups-of-patients-with-distinct-immune-phenotypes
#40
JOURNAL ARTICLE
Yannick Le Meitour, Jean-Philippe Foy, Mathilde Guinand, Lucas Michon, Andy Karabajakian, Jérôme Fayette, Pierre Saintigny, Karène Mahtouk
OBJECTIVES: In head and neck squamous cell carcinoma (HNSCC), PD-1/PD-L1 inhibitors remain inefficient in most patients, which points to the need for better characterization of immune checkpoint (ICP) molecule expression. MATERIAL AND METHODS: We evaluated the expression of 22 ICP ligands (ICPL) in 2,176 malignant cells from 10 patients in a public single-cell RNA-sequencing dataset and in two cohorts of HNSCC patients for which gene expression data are available...
January 12, 2024: Oral Oncology
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