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Extracapsular HNSCC

Qiaoshi Xu, Chong Wang, Xiaohong Yuan, Zhien Feng, Zhengxue Han
BACKGROUND: The prognostic value of tumor-infiltrating lymphocytes (TILs) in head and neck squamous cell carcinoma (HNSCC) remains controversial. Additionally, there is no standardized approach or cutoff value for evaluating TIL levels. The aim of this study was to establish a feasible method and criterion to assess TIL levels for future clinical practice and research use and to explore the relationship between TIL levels and prognosis. PATIENTS AND METHODS: This retrospective cohort study reviewed the records and pathological sections of 202 patients with HNSCC who were surgically treated at Beijing Stomatological Hospital, Capital Medical University, from January 1998 to January 2011...
November 23, 2016: Translational Oncology
Maxime Mermod, Genrich Tolstonog, Christian Simon, Yan Monnier
Extracapsular spread (ECS) is one of the most important prognostic factors in head and neck squamous cell carcinoma (HNSCC). However, despite its major clinical relevance, there are still a number of important remaining issues regarding this condition. Indeed, standardized diagnostic and grading criteria of ECS are still lacking. The imaging modality of choice for its diagnosis is a matter of debate. Current research looking at the identification of specific biomarkers is ongoing. Recent findings demonstrate a direct correlation between the level of extension of ECS and a poor prognosis...
November 2016: Oral Oncology
R L Ferris, J L Geiger, S Trivedi, N C Schmitt, D E Heron, J T Johnson, S Kim, U Duvvuri, D A Clump, J E Bauman, J P Ohr, W E Gooding, A Argiris
BACKGROUND: Treatment intensification for resected, high-risk, head and neck squamous cell carcinoma (HNSCC) is an area of active investigation with novel adjuvant regimens under study. In this trial, the epidermal growth-factor receptor (EGFR) pathway was targeted using the IgG2 monoclonal antibody panitumumab in combination with cisplatin chemoradiotherapy (CRT) in high-risk, resected HNSCC. PATIENTS AND METHODS: Eligible patients included resected pathologic stage III or IVA squamous cell carcinoma of the oral cavity, larynx, hypopharynx, or human-papillomavirus (HPV)-negative oropharynx, without gross residual tumor, featuring high-risk factors (margins <1 mm, extracapsular extension, perineural or angiolymphatic invasion, or ≥2 positive lymph nodes)...
December 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
M S Chung, K L Cheng, Y J Choi, J L Roh, Y S Lee, S S Lee, J H Lee, J H Baek
AIM: To determine the interobserver reproducibility of measuring cervical lymph nodes at computed tomography (CT) in patients with head and neck squamous cell carcinoma (HNSCC) and to investigate the influence of finding extracapsular spread (ECS) at CT on measurement reliability. MATERIALS AND METHODS: The institutional review board approved the study protocol, and informed consent was obtained. A total of 146 patients with 224 suspicious lymph nodes underwent CT before treatment...
December 2016: Clinical Radiology
Maxime Mermod, Massimo Bongiovanni, Tatiana V Petrova, Elena A Dubikovskaya, Christian Simon, Genrich Tolstonog, Yan Monnier
BACKGROUND: The correlation between podoplanin expression and extracapsular spread in head and neck squamous cell carcinoma (HNSCC) has never been reported. The purpose of this study was to assess the predictive value of podoplanin expression for this parameter. METHODS: Subjective immunoreactivity scores and semiquantitative image analysis of podoplanin expression were performed in 67 patients with primary oral squamous cell carcinoma and in their corresponding lymph nodes...
January 2017: Head & Neck
Faya Liang, Song Fan, Ping Han, Qian Cai, Peiliang Lin, Renhui Chen, Shitong Yu, Xiaoming Huang
BACKGROUND: Primary tumors of early-stage (T1-2N0M0) head and neck squamous cell carcinoma (HNSCC) can be treated by transoral minimally invasive surgery, but the cervical lymph node lacks corresponding minimally invasive treatment. Therefore, our study was to evaluate the safety and effectiveness of endoscopic-assisted selective neck dissection (EASND) via small lateral neck incision in treatment of early-stage HNSCC. METHODS: From May 2008 to April 2012, 29 patients with early-stage HNSCC were enrolled in this retrospective study...
July 1, 2016: Surgical Endoscopy
Vinita Takiar, Adam S Garden, Dominic Ma, William H Morrison, Mark Edson, Mark E Zafereo, Gary B Gunn, Clifton D Fuller, Beth Beadle, Steven J Frank, William N William, Merrill Kies, Adel K El-Naggar, Randal Weber, David I Rosenthal, Jack Phan
PURPOSE: To review our 15-year institutional experience using intensity modulated radiation therapy (IMRT) to reirradiate patients with head and neck squamous cell carcinomas (HNSCC) and identify predictors of outcomes and toxicity. METHODS AND MATERIALS: We retrospectively reviewed the records of 227 patients who received head and neck reirradiation using IMRT from 1999 to 2014. Patients treated with noncurative intent were excluded. Radiation-related acute and late toxicities were recorded...
July 15, 2016: International Journal of Radiation Oncology, Biology, Physics
Matthew H Bertke, Joseph N Shaughnessy, Matthew K Forsthoefel, Liz D Cash, Craig L Silverman, Jeffrey M Bumpous, Kevin L Potts, Rebecca A Redman, Cesar A Perez, Neal E Dunlap
BACKGROUND: There are limited data on the prognostic significance of human papillomavirus (HPV) status in relation to traditional risk factors for head and neck squamous-cell carcinoma (HNSCC) in the postoperative setting. OBJECTIVE: To clarify the impact of HPV status on the risk for HNSCC in the postoperative setting. METHODS: We retrospectively evaluated an institutional cohort of 128 patients with HNSCC patients who had been treated with definitive surgery with or without adjuvant radiotherapy or chemoradiotherapy...
May 2016: Journal of Community and Supportive Oncology
Arya Amini, Jagar Jasem, Bernard L Jones, Tyler P Robin, Jessica D McDermott, Shilpa Bhatia, David Raben, Antonio Jimeno, Daniel W Bowles, Sana D Karam
OBJECTIVES: This study identifies clinical characteristics associated with HPV-positive oropharynx squamous cell carcinoma (OPSCC) and evaluates predictors of overall survival (OS) in HPV-positive patients undergoing definitive treatment within the National Cancer Data Base (NCDB). MATERIAL AND METHODS: The NCDB was queried for patients ⩾18years old with OPSCC and known HPV status who underwent definitive treatment: surgery, radiation (RT), chemotherapy-RT (CRT), surgery+RT, surgery+CRT (S-CRT)...
May 2016: Oral Oncology
Valentina Krstevska
The employment of surgery as a single treatment modality for patients with resectable locally advanced head and neck squamous cell carcinoma (HNSCC) has been associated with high rates of locoregional recurrences even after adequate resection. The addition of postoperative radiotherapy (RT) as adjuvant to surgical resection for advanced HNSCC was investigated in an effort to decrease locoregional failure rates and improve treatment outcome. The unsatisfactory results in terms of locoregional control (LRC) and survival rates achieved with postoperative RT in patients with high-risk features have led to the necessity of exploring the role of concurrent chemotherapy in the adjuvant treatment in resectable advanced HNSCC with confirmed presence of high-risk pathological features...
July 2015: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Akifumi Fujita, Karen Buch, Minh Tam Truong, Muhammad M Qureshi, Gustavo Mercier, Scharukh Jalisi, Hideharu Sugimoto, Osamu Sakai
OBJECTIVES/HYPOTHESIS: Although several imaging characteristics of human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) have been reported, imaging features of nodal metastasis and influence to outcomes have not been well studied thus far. The purpose of the study was to investigate the imaging characteristics of nodal metastasis by HPV status in HNSCC and to clarify whether those findings influence the outcomes. STUDY DESIGN: Retrospective review...
February 2016: Laryngoscope
Jessica H Maxwell, Tanya J Rath, James K Byrd, William G Albergotti, Hong Wang, Umamaheswar Duvvuri, Seungwon Kim, Jonas T Johnson, Barton F Branstetter, Robert L Ferris
OBJECTIVE: To determine the accuracy of pretreatment, contrast-enhanced computed tomography (CT) in the diagnosis of extracapsular spread (ECS) in cervical lymph node metastases from p16-positive head-and-neck squamous cell carcinoma (HNSCC). STUDY DESIGN: Retrospective observational study. METHODS: Sixty-five (n = 65) patients diagnosed between 2004 and 2013 with p16-positive HNSCC and with cervical lymph node metastases measuring at least 1 centimeter in diameter on pathological assessment were included...
July 2015: Laryngoscope
Chairat Burusapat, Weerawut Jarungroongruangchai, Mongkon Charoenpitakchai
BACKGROUND: Cervical nodal status is one of prognostic factors in head and neck squamous cell carcinoma (HNSCC). The objective of this study was to identify prognostic factors of cervical node status including site and size of primary tumors, presence of lymphovascular invasion, and size of cervical node for appropriate further treatment in HNSCC. METHODS: A 5-year retrospective review of patients with HNSCC in Phramongkutklao Hospital from 2009 to 2013 was conducted...
2015: World Journal of Surgical Oncology
Martin Lanzer, Sophie Bachna-Rotter, Matthias Graupp, Marius Bredell, Martin Rücker, Gerhard Huber, Sabine Reinisch, Paul Schumann
BACKGROUND: A diagnosis of squamous cell carcinoma of an unknown primary (CUP) is a major burden for patients. Because the location of the primary tumor is unclear, patients remain fearful of recurrence, which aggravates the uncertain prognosis of the disease. This study evaluates factors associated with long-term recurrence-free and overall survival of patients with CUP of the head and neck. Additionally, patient survival rates are compared with those of patients with head and neck squamous cell carcinoma (HNSCC)...
May 2015: Journal of Cranio-maxillo-facial Surgery
Chairat Burusapat, Weerawut Jarungroongruangchai, Mongkon Charoenpitakchai
BACKGROUND: Cervical nodal status is one of prognostic factors in head and neck squamous cell carcinoma (HNSCC). The objective of this study was to identify prognostic factors of cervical node status including site and size of primary tumors, presence of lymphovascular invasion, and size of cervical node for appropriate further treatment in HNSCC. METHODS: A 5-year retrospective review of patients with HNSCC in Phramongkutklao Hospital from 2009 to 2013 was conducted...
December 2015: World Journal of Surgical Oncology
Eleni M Rettig, Christine H Chung, Justin A Bishop, Jason D Howard, Rajni Sharma, Ryan J Li, Christopher Douville, Rachel Karchin, Evgeny Izumchenko, David Sidransky, Wayne Koch, Joseph Califano, Nishant Agrawal, Carole Fakhry
The Notch pathway is frequently altered in head and neck squamous cell carcinomas (HNSCC); however, the clinical significance of NOTCH1 dysregulation is poorly understood. This study was designed to characterize expression of the transcriptionally active NOTCH1 intracellular domain (NICD1) in HNSCCs and evaluate its association with NOTCH1 mutation status and clinical parameters. IHC for NICD1 was performed on 79 previously sequenced archival HNSCCs with known NOTCH1 mutation status. Three distinct immunohistochemical staining patterns were identified: positive/peripheral (47%), positive/nonperipheral (34%), and negative (19%)...
April 2015: Cancer Prevention Research
Weining Wang, Weng Khong Lim, Hui Sun Leong, Fui Teen Chong, Tony K H Lim, Daniel S W Tan, Bin Tean Teh, N Gopalakrishna Iyer
OBJECTIVES: Extracapsular spread (ECS) is an important prognostic factor for oral squamous cell carcinoma (OSCC) and is used to guide management. In this study, we aimed to identify an expression profile signature for ECS in node-positive OSCC using data derived from two different sources: a cohort of OSCC patients from our institution (National Cancer Centre Singapore) and The Cancer Genome Atlas (TCGA) head and neck squamous cell carcinoma (HNSCC) cohort. We also sought to determine if this signature could serve as a prognostic factor in node negative cancers...
April 2015: Oral Oncology
Bin Di, Xiaoming Li, Qi Song, Shuang Liu, Zhenfeng Tao, Shufen Xiao
OBJECTIVE: To investigate the clinicopathologic features and associated risk factors for bilateral neck node metastasis (BNM) in head and neck squamous cell carcinoma (HNSCC). METHODS: Two hundred eighty-six cases with HNSCC were retrospectively studied, including 83 cases of oral tongue cancers, 101 cases of hypopharyngeal cancers and 102 cases of supraglottic laryngeal cancers. All patients had unilateral or bilateral cervical lymph node metastasis confirmed by postoperative pathologic examinations...
May 2014: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
D Tighe, A Kwok, V Putcha, M McGurk
Audit of early postoperative outcomes adjusted for patient case mix is still in its infancy in head and neck surgery. Nevertheless the role for audit of early postoperative outcomes is obvious. The primary outcome measure of this study was to identify factors that are associated with early mortality or morbidity after surgery for head and neck squamous cell carcinoma (HNSCC). The secondary outcome measure was to develop a pilot score that allows for risk-adjustment of outcome data to facilitate departmental audit...
September 2014: International Journal of Oral and Maxillofacial Surgery
Sabine Reinisch, Astrid Kruse, Marius Bredell, Heinz-Theo Lübbers, Thomas Gander, Martin Lanzer
INTRODUCTION: TNM status is questioned as an exact predictor of survival in different tumour entities. Recently, lymph node ratio (LNR) has been described as a predictor of survival in patients with HNSCC. The purpose of this study was to evaluate to which degree LNR could be used as a more accurate predictor than TNM staging? METHODS: A total of 291 patients, with a follow-up of at least 3 years, were analyzed using log-rank statistic, univariate and multivariate data analyzes, and p values, for prediction of lymph node ratio on overall and recurrence-free survival...
June 2014: Annals of Surgical Oncology
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