Bouchra Tawk, Ute Wirkner, Christian Schwager, Katrin Rein, Karim Zaoui, Philippe A Federspil, Sebastian Adeberg, Annett Linge, Ute Ganswindt, Julia Hess, Kristian Unger, Ingeborg Tinhofer, Volker Budach, Fabian Lohaus, Mechthild Krause, Maja Guberina, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Anca L Grosu, Henning Schäfer, Daniel Zips, Stephanie E Combs, Steffi Pigorsch, Horst Zitzelsberger, Philipp Baumeister, Thomas Kirchner, Melanie Bewerunge-Hudler, Wilko Weichert, Jochen Hess, Esther Herpel, Claus Belka, Michael Baumann, Jürgen Debus, Amir Abdollahi
Biomarkers with relevance for loco-regional therapy are needed in Human Papillomavirus negative aka HPV(-) Head and Neck Squamous Cell Carcinoma (HNSCC). Based on the premise that DNA methylation pattern is highly conserved, we sought to develop a reliable and robust methylome-based classifier identifying HPV(-) HNSCC patients at risk for loco-regional recurrence (LR) and all-event progression after postoperative radiochemotherapy (PORT-C). The training cohort consisted of HPVDNA negative HNSCC patients (n=128) homogeneously treated with PORT-C in frame of the German Cancer Consortium - Radiation Oncology Group (DKTK-ROG) multicenter biomarker trial...
October 14, 2021: International Journal of Cancer. Journal International du Cancer