Kazuaki Yasui, Ryota Kondou, Haruo Miyata, Akira Iizuka, Tadashi Ashizawa, Takeshi Nagashima, Keiichi Ohshima, Kenichi Urakami, Koji Muramatsu, Takashi Sugino, Ken Yamaguchi, Hirofumi Ogawa, Tsuyoshi Onoe, Hideyuki Harada, Hirofumi Asakura, Shigeyuki Murayama, Tetsuo Nishimura, Seiya Goto, Shinichi Okada, Takashi Mukaigawa, Satoshi Hamauchi, Tomoya Yokota, Yusuke Onozawa, Yasuto Akiyama
BACKGROUND/AIM: The recurrence rate of head and neck squamous cell carcinoma (HNSCC) remains high; thus the control of recurrence is a clinical problem to be challenged. To clarify the precise mechanism, specific immunological biomarkers responsible for recurrence were investigated. PATIENTS AND METHODS: The expression levels of immune response-associated and Shizuoka Cancer Center 820 cancer-associated genes, and genetic mutations from whole-exome sequencing were compared between HNSCC patients who developed recurrence (n=8) and HNSCC patients who did not develop recurrence (n=19) using a volcano plot analysis...
September 2022: Anticancer Research