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HPV Oropharynx

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https://www.readbyqxmd.com/read/28541790/long-lasting-increased-risk-of-human-papillomavirus-related-carcinomas-and-premalignancies-after-cervical-intraepithelial-neoplasia-grade-3-a-population-based-cohort-study
#1
Renée M F Ebisch, Dominiek W E Rutten, Joanna IntHout, Willem J G Melchers, Leon F A G Massuger, Johan Bulten, Ruud L M Bekkers, Albert G Siebers
Purpose The aim of this study was to determine the risk of human papillomavirus (HPV)-related carcinomas and premalignancies in women diagnosed with cervical intraepithelial neoplasia grade 3 (CIN3). Knowledge of this risk is important to preventing the development and progression of other HPV-related premalignancies and carcinomas, by considering prophylactic HPV vaccination and/or by paying increased attention to other HPV-related carcinomas and premalignancies when CIN3 is identified. Methods Women diagnosed with a CIN3 between 1990 and 2010 were identified from the Dutch nationwide registry of histopathology and cytopathology (PALGA) and matched with a control group of women without CIN3...
May 25, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28531205/cost-analysis-of-human-papillomavirus-related-cervical-diseases-and-genital-warts-in-swaziland
#2
Themba G Ginindza, Benn Sartorius, Xolisile Dlamini, Ellinor Östensson
BACKGROUND: Human papillomavirus (HPV) has proven to be the cause of several severe clinical conditions on the cervix, vulva, vagina, anus, oropharynx and penis. Several studies have assessed the costs of cervical lesions, cervical cancer (CC), and genital warts. However, few have been done in Africa and none in Swaziland. Cost analysis is critical in providing useful information for economic evaluations to guide policymakers concerned with the allocation of resources in order to reduce the disease burden...
2017: PloS One
https://www.readbyqxmd.com/read/28530265/papillary-squamous-cell-carcinoma-of-the-palatine-tonsil-a-rare-cancer-of-the-head-and-neck
#3
A Serra, R Caltabiano, G Scalia, S Palmucci, P Di Mauro, S Cocuzza
Papillary squamous neoplasms of the upper respiratory tract are rare variants of squamous cell carcinomas. They are characterised by an exophytic, papillary growth and generally have favourable prognosis. The tumour has been described in the upper aerodigestive tract. In this context, most common sites of involvement are the larynx and hypopharynx, and rarely the oral cavity and oropharynx. The limited studies and small number of published cases of papillary squamous cell carcinoma of the palatine tonsil led us to make a complete analysis of this tumour by analysing the clinical, histological, radiological, virological and therapeutic aspects that are not always present in the literature...
May 22, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28528690/clinical-relevance-and-implications-of-hpv-induced-neoplasia-in-different-anatomical-locations
#4
REVIEW
Elena Sophie Prigge, Magnus von Knebel Doeberitz, Miriam Reuschenbach
Human papillomaviruses (HPV) are widespread DNA viruses that can infect epithelial cells of the skin and mucosa. Most HPV infections remain clinically unapparent and clear spontaneously. In few cases, however, HPV infections persist and can cause benign and malignant neoplasms at different anatomic locations. Malignant HPV-induced neoplasms are caused by distinct types of HPV (oncogenic or high-risk (HR) HPV types) and present in the anogenital (anus, penis, uterine cervix, vagina and vulva) and head and neck (particularly oropharynx) region...
April 2017: Mutation Research
https://www.readbyqxmd.com/read/28528398/squamous-and-neuroendocrine-specific-immunohistochemical-markers-in-head-and-neck-squamous-cell-carcinoma-a-tissue-microarray-study
#5
J S Lewis, R D Chernock, J A Bishop
The performance characteristics of neuroendocrine-specific and squamous-specific immunohistochemical markers in head and neck squamous cell carcinomas (SCC), in particular in oropharyngeal tumors in this era of human papillomavirus (HPV)-induced cases, are not well-established. The differential diagnosis for poorly differentiated SCCs, for nonkeratinizing oropharyngeal SCCs, and for other specific SCC variants such as basaloid SCC and undifferentiated (or lymphoepithelial-like) carcinomas includes neuroendocrine carcinomas...
May 20, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28511960/inadequate-target-volume-delineation-and-local-regional-recurrence-after-intensity-modulated-radiotherapy-for-human-papillomavirus-positive-oropharynx-cancer
#6
Allen M Chen, Robert Chin, Philip Beron, Taeko Yoshizaki, Argin G Mikaeilian, Minsong Cao
PURPOSE: To perform a spatial analysis of local-regional recurrences, in relation to quantitative dose distribution, among patients treated by intensity-modulated radiotherapy (IMRT) for human papillomavirus (HPV)-positive oropharyngeal cancer. METHODS AND MATERIALS: The records of 107 consecutive patients who presented for consideration of re-irradiation for local-regional recurrent disease occurring in a previously irradiated field were reviewed. The original IMRT plans were retrieved for those with HPV-positive disease originating from the oropharynx, and deformable image registration was used to fuse the magnetic resonance imaging (MRI) and positron emission tomography (PET) scans obtained at recurrence to the pre-treatment planning computed tomography (CT) dataset...
May 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28481782/oral-human-papillomavirus-in-women-with-high-grade-cervical-intraepithelial-neoplasia
#7
Linn Woelber, Julia Breuer, Thomas Meyer, Eik Vettorazzi, Katharina Prieske, Inga Bohlmann, Chia-Jung Busch, Ingo Teudt, Oliver Brummer, Volkmar Mueller, Barbara Schmalfeldt, Donata Grimm
OBJECTIVE: This study was designed to investigate the co-prevalence of cervical and oropharyngeal human papillomavirus (HPV) infection in patients with HPV-related high-grade disease of the uterine cervix (high-grade squamous intraepithelial lesion [HSIL]). MATERIALS AND METHODS: In a prospective cohort study, women with abnormal cervical cytology admitted to our colposcopy units received HPV testing of the uterine cervix and the oropharynx via smear. From a subset of patients, oral lavage was collected to compare detection rates of HPV DNA between lavage and swab...
May 5, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28463105/prevalence-of-hpv-in-adults-aged-18-69-united-states-2011-2014
#8
Geraldine McQuillan, Deanna Kruszon-Moran, Lauri E Markowitz, Elizabeth R Unger, Ryne Paulose-Ram
Data from the National Health and Nutrition Examination Survey Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States (1). Some HPV types can cause genital warts and are considered low risk, with a small chance for causing cancer. Other types are considered high risk, causing cancer in different areas of the body including the cervix and vagina in women, penis in men, and anus and oropharynx in both men and women (2). This report provides the most recent national estimates of oral HPV prevalence among adults aged 18-69 from the National Health and Nutrition Examination Survey (NHANES) 2011-2014, as well as prevalence of genital HPV among adults aged 18-59 from NHANES 2013-2014...
April 2017: NCHS Data Brief
https://www.readbyqxmd.com/read/28440978/methylation-status-of-p16ink4a-in-human-papillomavirus-associated-cancer-of-oral-cavity-and-oropharynx-in-northeastern-thailand
#9
Piyawut Swangphon, Chamsai Pientong, Ati Burassakarn, Patravoot Vatanasapt, Pilaiwan Kleebkaow, Natcha Patarapadungkit, Thanabut Treebupachatsakul, Supannee Promthet, Bunkerd Kongyingyoes, Tipaya Ekalaksananan
Background: Over-expression of p16INK4a protein is a biomarker for human papillomavirus (HPV)-associated cervical cancer. However, absence of p16INK4a protein expression in HPV-associated cancer of the oral cavity and oropharynx has been reported. Among a number of possible reasons for this is methylation, which is frequently noted in the promoter region of p16INK4a and is associated with silencing of the gene and disease severity. Methods: We investigated the relationships between p16INK4a protein expression, HPV infection and methylation status of the p16INK4a promoter in cancers of the oral cavity and oropharynx...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28438295/risk-factors-for-oropharynx-cancer-in-a-cohort-of-hiv-infected-veterans
#10
Erin Y Chew, Christine M Hartman, Peter A Richardson, Jose P Zevallos, Andrew G Sikora, Jennifer R Kramer, Elizabeth Y Chiao
OBJECTIVE: To evaluate HIV-related and other clinical risk factors associated with oropharynx cancer (OPSCC) in HIV-infected U.S. Veterans. METHODS: Retrospective cohort study utilizing Veterans Affairs HIV Clinical Case Registry (CCR) data from 1985 to 2010. Outcome was incident OPSCC as indicated by 1 inpatient or 2 outpatient ICD-9 codes. Cox proportional hazard models were used to determine hazard ratios (HR) and 95% confidence intervals (CI) for each risk factor on the time to OPSCC diagnosis...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28437239/tprevalence-of-hpv-in-adults-aged-18-69-united-states-2011-2014
#11
Geraldine McQuillan, Deanna Kruszon-Moran, Lauri E Markowitz, Elizabeth R Unger, Ryne Paulose-Ram
Data from the National Health and Nutrition Examination Survey ● During 2011-2014, prevalence of any oral human papillomavirus (HPV) for adults aged 18-69 was 7.3%; high-risk HPV was 4.0%. ● Overall, prevalence of any and high-risk oral HPV was lowest among non-Hispanic Asian adults; any oral HPV was highest among non-Hispanic black adults. ● Prevalence of any and high-risk oral HPV was higher in men than women except for high-risk HPV among Asian adults. ● During 2013-2014, prevalence of any and high-risk genital HPV for adults aged 18-59 was 45...
April 2017: NCHS Data Brief
https://www.readbyqxmd.com/read/28434660/reduced-dose-radiotherapy-for-human-papillomavirus-associated-squamous-cell-carcinoma-of-the-oropharynx-a-single-arm-phase-2-study
#12
Allen M Chen, Carol Felix, Pin-Chieh Wang, Sophia Hsu, Vincent Basehart, Jordan Garst, Phillip Beron, Deborah Wong, Michael H Rosove, Shyam Rao, Heather Melanson, Edward Kim, Daphne Palmer, Lihong Qi, Karen Kelly, Michael L Steinberg, Patrick A Kupelian, Megan E Daly
BACKGROUND: Head and neck cancers positive for human papillomavirus (HPV) are exquisitely radiosensitive. We investigated whether chemoradiotherapy with reduced-dose radiation would maintain survival outcomes while improving tolerability for patients with HPV-positive oropharyngeal carcinoma. METHODS: We did a single-arm, phase 2 trial at two academic hospitals in the USA, enrolling patients with newly diagnosed, biopsy-proven stage III or IV squamous-cell carcinoma of the oropharynx, positive for HPV by p16 testing, and with Zubrod performance status scores of 0 or 1...
April 20, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28427753/prognostic-markers-in-oropharyngeal-squamous-cell-carcinoma-focus-on-cd70-and-tumour-infiltrating-lymphocytes
#13
Astrid De Meulenaere, Tijl Vermassen, Sandrine Aspeslagh, Karen Zwaenepoel, Philippe Deron, Fréderic Duprez, Sylvie Rottey, Liesbeth Ferdinande
We evaluated the expression of CD70 as biomarker for prognosis in patients with oropharyngeal squamous cell carcinoma (OSCC). We also examined the prognostic value of tumour infiltrating lymphocytes (TILs) in our study cohort. Formalin fixed, paraffin embedded tissue originating from the oropharynx of 78 patients was immunohistochemically stained for CD70, CD3, CD8 and FoxP3. Expression of CD70, CD3, CD8, FoxP3 and HPV status was correlated with clinicopathological characteristics. Overall survival (OS) was determined by a log-rank (Mantel-Cox) test whereas the Cox proportional hazard model was used for multivariate analysis...
April 17, 2017: Pathology
https://www.readbyqxmd.com/read/28423662/comparative-analysis-of-hpv16-gene-expression-profiles-in-cervical-and-in-oropharyngeal-squamous-cell-carcinoma
#14
Andrea Cerasuolo, Clorinda Annunziata, Marianna Tortora, Noemy Starita, Giovanni Stellato, Stefano Greggi, Maria Grazia Maglione, Franco Ionna, Simona Losito, Gerardo Botti, Luigi Buonaguro, Franco M Buonaguro, Maria Lina Tornesello
Human papillomavirus type 16 (HPV16) is the major cause of cervical cancer and of a fraction of oropharyngeal carcinoma. Few studies compared the viral expression profiles in the two types of tumor. We analyzed HPV genotypes and viral load as well as early (E2/E4, E5, E6, E6*I, E6*II, E7) and late (L1 and L2) gene expression of HPV16 in cervical and oropharyngeal cancer biopsies. The study included 28 cervical squamous cell carcinoma (SCC) and ten oropharyngeal SCC, along with pair-matched non-tumor tissues, as well as four oropharynx dysplastic tissues and 112 cervical intraepithelial neoplasia biopsies...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417200/hpv-related-carcinomas-of-the-head-and-neck-morphologic-features-variants-and-practical-considerations-for-the-surgical-pathologist
#15
REVIEW
Todd M Stevens, Justin A Bishop
Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma is a distinct tumor entity with clinical, epidemiologic, genetic, histologic, prognostic, and treatment differences from smoking- and alcohol-related head and neck squamous cell carcinoma. This is now well known by the pathology and medical community. What is not yet widely known is that several emerging variants of HPV-related carcinoma of the head and neck exist apart from the prototypical non-keratinizing morphology. Further, there is currently considerable variation in methodologies used and clinical scenarios in which to test for HPV-related head and neck squamous cell carcinoma, and no standard approach has emerged...
April 17, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28416263/the-keys-to-conservative-treatment-of-early-stage-squamous-cell-carcinoma-of-the-tonsillar-region
#16
O Laccourreye, P Castelnau-Marchand, F Rubin, C Badoual, P Halimi, P Giraud
To analyze the medical literature devoted to work-up, epidemiology, local control, survival, complications and sequelae after conservative treatment for early-stage squamous cell carcinoma of the tonsillar region. An analysis of the PubMed (1975-2016) database was performed using the following keywords and associations: "tonsil/tonsillar region/oropharynx" AND "squamous cell carcinoma" AND "early-stage (I-II; T1-2N0M0)" AND "radiation therapy/radiotherapy" OR "conservative surgery/oropharyngectomy/transoral surgery/radical tonsillectomy"...
April 14, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28397651/-transmission-of-and-infection-with-human-papillomavirus-in-the-oropharynx
#17
Anne Bohr, Christian Grønhøj, Christel Lajer, Jan Gerstoft, Christian von Buchwald
The incidence of human papillomavirus (HPV)-associated oropharyngeal cancer is rising in the Western world, but little is known about transmission of the infection and the premalignant phase of the disease. In this article there is an overview of current knowledge with focus on transmission of HPV and risk factors which may lead to persistent infection and eventually cancer. Furthermore, there is a discussion about issues concerning the ability to measure and detect infection and the premalignant stadium in the oropharyngeal tissue...
March 27, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28391376/evolving-disparities-in-the-epidemiology-of-oral-cavity-and-oropharyngeal-cancers
#18
Pardis Javadi, Arun Sharma, Whitney E Zahnd, Wiley D Jenkins
Incidence rates of head and neck cancers (HNC) associated with human papillomavirus (HPVa) infection are increasing while non-HPV-associated (non-HPVa) HNC cancer rates are decreasing. As nearly all sexually active individuals will acquire an HPV infection, it is important to understand epidemiologic trends of HNCs associated with this sexually transmitted disease. We analyzed SEER 9 (1973-2012) and 18 data (2000-2012) for HPVa HNCs (oropharynx area; OP) and non-HPVa (oral cavity area; OC). Incidence rates were examined by gender, race, rurality, geographic location, and time...
April 8, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28376866/systemic-therapy-in-the-curative-treatment-of-head-and-neck-squamous-cell-cancer-a-systematic-review
#19
REVIEW
Eric Winquist, Chika Agbassi, Brandon M Meyers, John Yoo, Kelvin K W Chan
OBJECTIVE: To review the available evidence and make recommendations regarding use of systemically administered drugs in combination or in sequence with radiation (RT) and/or surgery for cure and/or organ preservation in patients with locally advanced nonmetastatic (Stage III to IVB) squamous cell carcinoma of the head and neck (LASCCHN). METHOD: Recognizing the Meta-analysis of Chemotherapy in Head and Neck Cancer (MACH-NC) group reports have de facto guided practice since 2000, we searched for systematic reviews in the MEDLINE, EMBASE and Cochrane Database of Systematic Reviews published from January 2000 to February 2015 in reference to 4 research questions...
April 4, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28369859/role-of-mucosal-high-risk-human-papillomavirus-types-in-head-and-neck-cancers-in-central-india
#20
Tarik Gheit, Devasena Anantharaman, Dana Holzinger, Laia Alemany, Sara Tous, Eric Lucas, Priya Ramesh Prabhu, Michael Pawlita, Ruediger Ridder, Susanne Rehm, Johannes Bogers, Fausto Maffini, Susanna Chiocca, Belén Lloveras, Rekha Vijay Kumar, Thara Somanathan, Silvia de Sanjosé, Xavier Castellsagué, Marc Arbyn, Paul Brennan, Rengaswamy Sankaranarayanan, Madhavan Radhakrishna Pillai, Nitin Gangane, Massimo Tommasino
Mucosal high-risk (HR) human papillomaviruses (HPV) cause a subset of head and neck cancers (HNC). The HPV-attributable fraction of HNC varies substantially between countries. Although HNC has a very high incidence in the Indian subcontinent, information on the contribution of HPV infection is limited. Here, we evaluated the HPV-attributable fraction in HNC (N = 364) collected in a central region of India. HNC from three different anatomical subsites were included, namely, oral cavity (n = 252), oropharynx (n = 53) and hypopharynx/larynx (n = 59)...
March 29, 2017: International Journal of Cancer. Journal International du Cancer
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