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HPV Oropharynx

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https://www.readbyqxmd.com/read/29673737/epidemiological-features-of-cancers-of-the-oral-cavity-oropharynx-hypopharynx-and-larynx-cancer-in-r%C3%A3-union-island
#1
A Delagranda, G Leterme, E Chirpaz, C Ferdynus, C Fernandez, F Rubin
INTRODUCTION: This study had two objectives: firstly, to identify and compare characteristics of cancer of the oral cavity, oropharynx, hypopharynx and larynx in Réunion Island, a tropical French overseas territory in the southern hemisphere; and secondly, to discuss how incidence of these cancers is presented in the international literature. MATERIAL AND METHOD: A retrospective study included 599 patients diagnosed with cancer of the oral cavity, oropharynx, hypopharynx or larynx between 2009 and 2013 in Réunion Island...
April 16, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29670856/cdkn2a-copy-number-loss-is-an-independent-prognostic-factor-in-hpv-negative-head-and-neck-squamous-cell-carcinoma
#2
William S Chen, Ranjit S Bindra, Allen Mo, Thomas Hayman, Zain Husain, Joseph N Contessa, Stephen G Gaffney, Jeffrey P Townsend, James B Yu
Background: HPV infection is associated with high p16 expression and good prognosis in head and neck squamous cell carcinomas (HNSCCs). Analysis of CDKN2A, the gene encoding p16, may further elucidate the association between p16 expression and prognosis. We sought to determine whether CDKN2A copy number loss was associated with poor survival in HPV-negative HNSCCs. Methods: The Cancer Genome Atlas HNSCC clinical and genomic data were obtained and integrated. Patients <80 years old with a primary tumor in the oral cavity, oropharynx, hypopharynx, or larynx were included...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29628167/clinicopathological-features-of-squamous-cell-carcinoma-of-the-oral-cavity-and-oropharynx-in-young-patients
#3
R C-P Martinez, H P Sathasivam, B Cosway, V Paleri, S Fellows, J Adams, M Kennedy, R Pearson, A Long, P Sloan, M Robinson
Our aim was to examine the clinicopathological features of squamous cell carcinoma (SCC) of the oral cavity and oropharynx in a group of young patients who were dignosed during a 15-year period (2000-2014). Patients' clinical details, risk factors, and survival were obtained from medical records. Formalin-fixed, paraffin-embedded, tissue was tested for high-risk human papillomavirus (HPV). The results were compared with those of a matching group of older patients. We identified 91 patients who were younger than 45 years old, and the 50 youngest patients were studied in detail...
April 5, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29594250/anti-pd-l1-durvalumab-combined-with-cetuximab-and-radiotherapy-in-locally-advanced-squamous-cell-carcinoma-of-the-head-and-neck-a-phase-i-ii-study-ducro
#4
Pierluigi Bonomo, Isacco Desideri, Mauro Loi, Monica Mangoni, Mariangela Sottili, Livia Marrazzo, Cinzia Talamonti, Daniela Greto, Stefania Pallotta, Lorenzo Livi
Introduction and background: Head and neck squamous cell carcinoma (HNSCC) has been increasingly recognized as an immune suppressive malignancy. The efficacy of immune checkpoint inhibitors (ICI's) in the context of recurrent/metastatic (R/M) setting anticipates the possible integration of immunotherapy into the therapeutic armamentarium of locally advanced disease. Durvalumab (DUR) is a humanized monoclonal IgG1, anti-PD-L1 antibody with promising data in R/M HNSCC. The aim of our study is to test the antitumor activity of a combined regimen incorporating an immune checkpoint inhibitor into a conventional bio-radiation strategy for the cure of unfavorable locally advanced HNSCC...
February 2018: Clinical and translational radiation oncology
https://www.readbyqxmd.com/read/29594229/radiomic-analysis-in-prediction-of-human-papilloma-virus-status
#5
Kaixian Yu, Youyi Zhang, Yang Yu, Chao Huang, Rongjie Liu, Tengfei Li, Liuqing Yang, Jeffrey S Morris, Veerabhadran Baladandayuthapani, Hongtu Zhu
Human Papilloma Virus (HPV) has been associated with oropharyngeal cancer prognosis. Traditionally the HPV status is tested through invasive lab test. Recently, the rapid development of statistical image analysis techniques has enabled precise quantitative analysis of medical images. The quantitative analysis of Computed Tomography (CT) provides a non-invasive way to assess HPV status for oropharynx cancer patients. We designed a statistical radiomics approach analyzing CT images to predict HPV status. Various radiomics features were extracted from CT scans, and analyzed using statistical feature selection and prediction methods...
December 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29594214/sdf-1-cxcr4-expression-in-head-and-neck-cancer-and-outcome-after-postoperative-radiochemotherapy
#6
Chiara De-Colle, David Mönnich, Stefan Welz, Simon Boeke, Bence Sipos, Falko Fend, Paul-Stefan Mauz, Inge Tinhofer, Volker Budach, Jehad Abu Jawad, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Anca-Ligia Grosu, Amir Abdollahi, Jürgen Debus, Christine Bayer, Claus Belka, Steffi Pigorsch, Stephanie E Combs, Fabian Lohaus, Annett Linge, Mechthild Krause, Michael Baumann, Daniel Zips, Apostolos Menegakis
Introduction: Outcome after postoperative radiochemotherapy (RT-CT) for patients with advanced head and neck squamous cell carcinomas (HNSCC) remains unsatisfactory, especially among those with HPV negative tumours. Therefore, new biomarkers are needed to further define subgroups for individualised therapeutic approaches. Preclinical and first clinical observations showed that the chemokine receptor CXCR4 and its ligand SDF-1 (CXCL12) play an important role in tumour cell proliferation, survival, cancer progression, metastasis and treatment resistance...
August 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29593938/oropharynx-hpv-status-and-its-relation-to-hiv-infection
#7
Leonora Maciel de Souza Vianna, Fabiana Pirani Carneiro, Rivadavio Amorim, Eliete Neves da Silva Guerra, Florêncio Figueiredo Cavalcanti Neto, Valdenize Tiziani, Andrea Barretto Motoyama, Anamélia Lorenzetti Bocca
Background: The number of oropharyngeal lesions caused by HPV (Human papillomavirus) has been increasing worldwide in the past years. In spite of the clinical relevance of HPV infection in the anogenital tract of HIV-positive patients, the relevance of oropharynx HPV infection in these patients is not clear. The aim of the present study was to detect HPV infection, and clinical and cytological changes in the oropharynx of HIV-positive patients. Methods: Samples collected from the oropharynx of 100 HIV-positive patients were subjected to hybrid capture (HC), conventional and liquid-based cytology...
2018: PeerJ
https://www.readbyqxmd.com/read/29555577/p16-positive-cystic-squamous-cell-carcinoma-in-midline-neck-metastasis-from-oropharynx-or-primary-carcinoma-arising-from-thyroglossal-duct-cyst
#8
Songlin Zhang, Hong D Xiao, Zhenjian Cai, Michael Covinsky, Karan Saluja, Maria O Patino, Xinmin Liu, Hui Zhu
Cystic squamous cell carcinoma (SCC) of the lateral neck is considered metastatic human papilloma virus (HPV)-related oropharyngeal SCC (HPV-OPSCC) until proven otherwise. P16 immunohistochemistry is diffusely positive in those carcinomas and is used as a surrogate marker of active human papillomavirus (HPV) infection. Thyroglossal duct cysts (TDC) are one of the differential diagnoses for cystic neck lesions. SCC arising from TDC is extremely rare. In this study, we report a p16-positive cystic SCC located in the midline neck...
March 16, 2018: Human Pathology
https://www.readbyqxmd.com/read/29533279/human-papillomavirus-driven-squamous-lesions-high-risk-genotype-found-in-conjunctival-papillomas-dysplasia-and-carcinoma
#9
Amanda B Moyer, Jordan Roberts, Randall J Olsen, Patricia Chévez-Barrios
BACKGROUND: Human papillomavirus (HPV) is a causative agent for intraepithelial squamous neoplasms, particularly on mucosal surfaces. HPV has a well-established association with squamous cell carcinoma (SCC) of the oropharynx and genital tract, and recent studies suggest a potential role in ocular and periocular squamous neoplasms. Multiple high-risk HPV genotypes are associated with histologically similar squamous neoplasms, and some HPV genotypes have been differentially associated with high- or low-grade lesions...
March 6, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29496048/evaluating-oropharyngeal-carcinoma-with-transcervical-ultrasound-ct-and-mri
#10
Farhoud Faraji, Stephanie F Coquia, Meghan B Wenderoth, Ericka S Padilla, Dana Blitz, M Robert DeJong, Nafi Aygun, Ulrike M Hamper, Carole Fakhry
OBJECTIVE: To compare transcervical ultrasonography (US) to standard cross-sectional imaging for the visualization of human papillomavirus-related oropharyngeal cancer (HPV-OPC). MATERIALS AND METHODS: Patients with HPV-OPC and available standard imaging (CT and/or MRI) were identified in clinic and prospectively enrolled. US was performed to visualize the oropharynx and lymph nodes. Tumor characteristics across imaging modalities were evaluated (CT versus MRI, and US versus standard imaging (SI))...
March 2018: Oral Oncology
https://www.readbyqxmd.com/read/29496037/pitfalls-of-post-treatment-pet-after-de-intensified-chemoradiotherapy-for-hpv-associated-oropharynx-cancer-secondary-analysis-of-a-phase-2-trial
#11
Kyle Wang, Terence Z Wong, Robert J Amdur, William M Mendenhall, Nathan C Sheets, Rebecca Green, Brian D Thorp, Samip N Patel, Trevor G Hackman, Adam M Zanation, Mark C Weissler, Bhishamjit S Chera
OBJECTIVES: We evaluated patterns of nodal response and positive predictive value (PPV) of 3 month post-treatment PET in patients with HPV-associated oropharyngeal cancer treated on a multi-institutional de-intensification trial. MATERIALS AND METHODS: Eligibility criteria included: (1) T0-3, N0-2c, M0, (2) HPV+/p16+ oropharyngeal squamous cell carcinoma, and (3) ≤10 pack-years smoking or ≤30 pack-years and abstinent ≥5 years. Patients received 60 Gy radiation alone (T0-2, N0-1) or with concurrent weekly cisplatin 30 mg/m2 and surveillance PET three months post-radiation...
March 2018: Oral Oncology
https://www.readbyqxmd.com/read/29493423/immune-cell-infiltration-in-head-and-neck-squamous-cell-carcinoma-and-patient-outcome-a-retrospective-study
#12
Karolin Schneider, Etienne Marbaix, Caroline Bouzin, Marc Hamoir, Pierre Mahy, Vanesa Bol, Vincent Grégoire
BACKGROUND: Human papillomavirus (HPV) prevalence in oropharynx squamous cell carcinoma (OPSCC) is on the rise. HPV-linked OPSCCs represent a distinct clinical entity with a better treatment response and patient survival compared to tumors not linked to HPV. An emerging role in treatment response has been attributed to immune cell infiltration in human tumors. In this study, we investigated immune cell infiltration in human SCC of the head and neck region and its relation to overall survival after treatment with surgery (with or without radiotherapy) or concomitant chemo (or cetuximab)-radiotherapy...
March 1, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29476028/long-term-incidence-trends-of-hpv-related-cancers-and-cases-preventable-by-hpv-vaccination-a-registry-based-study-in-norway
#13
Bo T Hansen, Suzanne Campbell, Mari Nygård
OBJECTIVES: Examine long-term incidence trends of human papillomavirus (HPV)-related cancer in Norway, and estimate the number of cancer cases preventable by vaccines against HPV 16/18 or HPV 16/18/31/33/45/52/58. DESIGN: Observational registry-based study. We extracted incident cases of HPV-related cancer during 1953-2015 from the Cancer Registry of Norway. Tumour HPV prevalence estimates from large international meta-analyses or from Norway were used to estimate the protective potential of HPV vaccines...
February 23, 2018: BMJ Open
https://www.readbyqxmd.com/read/29463556/-tgf%C3%AE-1-genetic-variants-predict-clinical-outcomes-of-hpv-positive-oropharyngeal-cancer-patients-after-definitive-radiotherapy
#14
Ye Tao, Erich M Sturgis, Zhigang Huang, Ying Wang, Peng Wei, Jennifer Rui Wang, Qingyi Wei, Guojun Li
Purpose: TGFβ1 plays a critical role in inflammation and immune responses and treatment response and survival. TGFβ1 variants may affect its expression level or functional efficiency, thus modifying tumor status and survival in human papillomavirus (HPV)-positive squamous cell carcinoma of the oropharynx (SCCOP). Experimental Design: We determined tumor HPV16 status and genotyped three TGFβ1 polymorphisms in 564 incident SCCOP patients treated with radiotherapy or chemoradiation. Univariate and multivariable Cox models were used to evaluate the associations between the three polymorphisms and survival...
February 20, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29460521/hpv-acting-on-e-cadherin-p53-and-p16-literature-review
#15
L Ottria, V Candotto, F Cura, L Baggi, C Arcuri, M Nardone, R M Gaudio, R Gatto, F Spadari, F Carinci
In addition to tobacco and alcohol consumption, the two main risk factors for oral squamous cell carcinoma (OSCC), recent studies have revealed infections with human papilloma virus (HPV) as an additional risk factor for OSCC development. In the field of head and neck malignancies, the prevalence of HPV infections in oropharyngeal cancer (OC) ranges in different studies up to 84%. While HPV infection is discussed as an independent risk factor in this region, its distinguished role in carcinogenesis of tumours localized to the oral cavity remains uncertain...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29452770/single-arm-phase-2-trial-of-elective-nodal-dose-reduction-for-patients-with-locoregionally-advanced-squamous-cell-carcinoma-of-the-head-and-neck
#16
Patrick D Maguire, Charles R Neal, Stuart M Hardy, Andrew M Schreiber
PURPOSE: To evaluate a novel chemoradiation therapy (CRT) regimen for patients with squamous cell carcinoma of the head and neck (SCCHN) incorporating a lower intensity modulated radiation therapy dose to electively treated neck lymph nodes than is currently standard. METHODS AND MATERIALS: Eligible patients had locally advanced SCCHN of the oral cavity, oropharynx, larynx, or hypopharynx. The 7-week CRT course consisted of weekly cisplatin at 35 mg/m2 concurrently with sequential-boost intensity modulated radiation therapy: 36 Gy to high- and low-risk planning target volumes followed by a sequential boost to the high-risk planning target volume to 70 Gy...
December 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29447361/laryngeal-squamous-cell-papilloma-is-highly-associated-with-human-papillomavirus
#17
Yorihisa Orita, Yuka Gion, Tomoyasu Tachibana, Kana Ikegami, Hidenori Marunaka, Seiichiro Makihara, Yasuhiko Yamashita, Kentaro Miki, Takuma Makino, Naoki Akisada, Yusuke Akagi, Miyuki Kimura, Tadashi Yoshino, Kazunori Nishizaki, Yasuharu Sato
Objective: To delineate the association between characteristics of adult-onset laryngeal squamous cell papilloma and human papillomavirus (HPV) infection. Methods: Clinical records and paraffin-embedded specimens of 77 papilloma patients who had been treated between 1998 and 2014 were collected. Of the 77 cases, 34 were identified in the larynx, 28 in the oral cavity and 15 in the oropharynx. Specimens were investigated by polymerase chain reaction (PCR) to detect HPV 6, 11, 16, 18, 31, 33, 35, 52b and 58, and immunohistochemical (IHC) staining for anti-p16INK4a antibody...
February 13, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29440171/crosstalk-signaling-between-her3-and-hpv16-e6-and-e7-mediates-resistance-to-pi3k-inhibitors-in-head-and-neck-cancer
#18
Toni M Brand, Stefan Hartmann, Neil E Bhola, Hua Li, Yan Zang, Rachel A O'Keefe, Max V Ranall, Sourav Bandyopadhyay, Margaret Soucheray, Nevan J Krogan, Carolyn Kemp, Umamaheswar Duvvuri, Theresa LaVallee, Daniel E Johnson, Michelle A Ozbun, Julie E Bauman, Jennifer R Grandis
Human papillomavirus (HPV) type 16 is implicated in approximately 75% of head and neck squamous cell carcinomas (HNSCC) that arise in the oropharynx, where viral expression of the E6 and E7 oncoproteins promote cellular transformation, tumor growth, and maintenance. An important oncogenic signaling pathway activated by E6 and E7 is the phosphatidylinositol 3-kinase (PI3K) pathway, a key driver of carcinogenesis. The PI3K pathway is also activated by mutation or amplification of PIK3CA in over half of HPV(+) HNSCC...
February 12, 2018: Cancer Research
https://www.readbyqxmd.com/read/29415020/the-evolution-of-the-epidemiological-landscape-of-head-and-neck-cancer-in-italy-is-there-evidence-for-an-increase-in-the-incidence-of-potentially-hpv-related-carcinomas
#19
Paolo Boscolo-Rizzo, Manuel Zorzi, Annarosa Del Mistro, Maria Cristina Da Mosto, Giancarlo Tirelli, Carlotta Buzzoni, Massimo Rugge, Jerry Polesel, Stefano Guzzinati
The current study aimed to investigate the incidence and survival patterns of HNSCCs arising from different anatomic sites, potentially related (the oropharynx) or unrelated (the oral cavity, the larynx/hypopharynx) to HPV, to provide clues on possible growing impact of HPV in the epidemiology of HNSCC in Italy. Epidemiological data were retrieved from ten long-term Cancer Registries covering a population of 7.8 million inhabitants. Trends were described by means of the estimated annual percent change (APC) stratified by age and gender, and compared between HPV-related and HPV-unrelated anatomical sites...
2018: PloS One
https://www.readbyqxmd.com/read/29408738/prevalence-and-genotypes-of-human-papillomavirus-in-saliva-and-tumor-samples-of-head-and-neck-cancer-patients-in-hungary
#20
Andrea Hettmann, Anett Demcsák, Ádám Bach, Gábor Decsi, Ágnes Dencs, Dóra Pálinkó, László Rovó, Gabriella Terhes, Edit Urbán, Krisztina Buzás, Katalin Nagy, Mária Takács, Janos Minarovits
In addition to traditional risk factors such as smoking, alcohol consumption and betel nut use, human papillomavirus (HPV) infection also plays a role in the development of head and neck squamous cell carcinomas (HNSCCs). Although among European countries the highest incidence and mortality rates of head and neck cancer types were recorded in Hungary, data regarding HPV prevalence in HNSCCs is scarce. We collected biopsy and saliva samples from patients diagnosed with HNSCC or oral potentially malignant disorders (OPMDs) and tested them for the presence of HPV using the PCR consensus primer set MY09/11 and the GP5+/6+ primer pair...
January 31, 2018: Infection, Genetics and Evolution
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