Liqun Ning, Stefano Zanella, Martin L Tomov, Mehdi Salar Amoli, Linqi Jin, Boeun Hwang, Maher Saadeh, Huang Chen, Sunder Neelakantan, Lakshmi Prasad Dasi, Reza Avazmohammadi, Morteza Mahmoudi, Holly D Bauser-Heaton, Vahid Serpooshan
Vascular cell overgrowth and lumen size reduction in pulmonary vein stenosis (PVS) can result in elevated PV pressure, pulmonary hypertension, cardiac failure, and death. Administration of chemotherapies such as rapamycin have shown promise by inhibiting the vascular cell proliferation; yet clinical success is limited due to complications such as restenosis and off-target effects. The lack of in vitro models to recapitulate the complex pathophysiology of PVS has hindered the identification of disease mechanisms and therapies...
May 2, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)