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https://www.readbyqxmd.com/read/29352727/re-evaluation-of-target-lipid-model-derived-hc5-predictions-for-hydrocarbons
#1
Joy A McGrath, Christopher J Fanelli, Dominic M Di Toro, Thomas F Parkerton, Aaron D Redman, Miriam Leon Paumen, Mike Comber, Charles V Eadsforth, Klaas den Haan
The Target Lipid Model (TLM) has been previously applied to predict the aquatic toxicity of hydrocarbons and other non-ionic organic chemicals and for deriving HC5 values, concentrations above which 95% of species should be protected. Several concerns were identified with the TLM-derived HC5 when applied in a substance risk assessment context. These shortcomings were addressed by expanding the acute and chronic toxicity databases to include more diverse taxonomic groups and increase the number of species. The TLM was recalibrated with these expanded databases resulting in critical target lipid body burdens and acute-to-chronic ratios that met the required guidelines for using species sensitivity distributions in substance risk assessment...
January 20, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29352708/a-systematic-review-and-discussion-of-symptom-specific-cognitive-behavioural-approaches-to-delusions-and-hallucinations
#2
Tania M Lincoln, Emmanuelle Peters
Studies on cognitive behavioural therapy for psychosis (CBTp) have developed from evaluating generic approaches to focusing on specific symptoms. The evidence for targeted studies on delusions and hallucinations was reviewed. We included randomized controlled trials (RCTs) examining the effect of individualized CBT-based interventions focusing either on delusions or on hallucinations. Twelve suitable RCTs were identified. Four RCTs focused on delusions, of which three took a focused approach targeting mechanisms assumed causal to persecutory delusions...
January 16, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29352706/environmental-conditions-in-health-care-facilities-in-low-and-middle-income-countries-coverage-and-inequalities
#3
Ryan Cronk, Jamie Bartram
Safe environmental conditions and the availability of standard precaution items are important to prevent and treat infection in health care facilities (HCFs) and to achieve Sustainable Development Goal (SDG) targets for health and water, sanitation, and hygiene. Baseline coverage estimates for HCFs have yet to be formed for the SDGs; and there is little evidence describing inequalities in coverage. To address this, we produced the first coverage estimates of environmental conditions and standard precaution items in HCFs in low- and middle-income countries (LMICs); and explored factors associated with low coverage...
January 11, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29352688/the-association-between-readmission-and-patient-experience-in-a-total-hip-arthroplasty-population
#4
(no author information available yet)
BACKGROUND: Our goal was to determine whether readmissions within 30 or 90 days following discharge are associated with Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) scores for total hip arthroplasty (THA) patients. METHODS: HCAHPS surveys from all patients who underwent THA between January 2016 and September 2016 in our institution were analyzed. Readmissions, demographics, baseline joint pain, joint function, and Veterans RAND-12 scores were collected...
December 29, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29352662/distinct-progression-patterns-of-brain-disease-in-infantile-and-juvenile-gangliosidoses-volumetric-quantitative-mri-study
#5
Igor Nestrasil, Alia Ahmed, Josephine M Utz, Kyle Rudser, Chester B Whitley, Jeanine R Jarnes-Utz
BACKGROUND: GM1-gangliosidosis and GM2-gangliosidosis (Tay-Sachs disease and Sandhoff disease) are unrelenting heritable neurodegenerative conditions of lysosomal ganglioside accumulation. Although progressive brain atrophy is characteristic, longitudinal quantification of specific brain structures has not been systematically studied. OBJECTIVES: The goal of this longitudinal study has been to quantify and track brain MRI volume changes, including specific structure volume changes, at different times in disease progression of childhood gangliosidoses, and to explore quantitative brain MRI volumetry (qMRI) as a non-invasive marker of disease progression for future treatment trials...
December 20, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29352618/point-shear-wave-elastography-of-the-spleen-its-role-in-patients-with-portal-hypertension
#6
Natalie Lucchina, Chiara Recaldini, Monica Macchi, Valeria Molinelli, Mario Montanari, Sergio Segato, Raffaele Novario, Carlo Fugazzola
The goals of the study described here were to evaluate the feasibility and reproducibility of measuring spleen stiffness (SS) using point shear wave elastography in a series of cirrhotic patients and to investigate whether SS, liver stiffness (LS) and other non-invasive parameters are correlated with the presence of esophagogastric varices (EVs). Fifty-four cirrhotic patients with low-grade EVs or without EVs at esophago-gastro-duodenoscopy were enrolled. They underwent abdominal ultrasound and Doppler ultrasound of hepatic vessels simultaneously with p-SWE of the liver and spleen...
January 15, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29352598/who-consultation-on-etec-and-shigella-burden-of-disease-geneva-6-7th-april-2017-meeting-report
#7
Divya Hosangadi, Peter G Smith, David C Kaslow, Birgitte K Giersing
According to the 2015 Global Burden of Disease Study, diarrhea ranked ninth among causes of death for all ages, and fourth among children under 5 years old, accounting for an estimated 499,000 deaths in this young age group. It was also the second most common cause of years lived with disability (2.39 billion YLDs). The goal of the WHO/UNICEF Integrated Global Action Plan for the Prevention and Control of Pneumonia and Diarrhea (GAPPD) is to reduce deaths from diarrhea in children under 5 years of age to less than 1 per 1000 live births, by 2025...
January 15, 2018: Vaccine
https://www.readbyqxmd.com/read/29352575/double-plication-for-spring-mediated-intestinal-lengthening-of-a-defunctionalized-roux-limb
#8
Genia Dubrovsky, Nhan Huynh, Anne-Laure Thomas, Shant Shekherdimian, James C Y Dunn
BACKGROUND: Spring-mediated distraction enterogenesis has been shown to increase the length of an intestinal segment. The goal of this study is to use suture plication to confine a spring within an intestinal segment while maintaining luminal patency to the rest of the intestine. METHODS: Juvenile mini-Yucatan pigs underwent placement of nitinol springs within a defunctionalized Roux limb of jejunum. A 20 French catheter was passed temporarily, and sutures were used to plicate the intestinal wall around the catheter at both ends of the encapsulated spring...
December 26, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29352525/an-mrm-based-cytokeratin-marker-assay-as-a-tool-for-cancer-studies-application-to-lung-cancer-pleural-effusions
#9
Anna Perzanowska, Agnieszka Fatalska, Grzegorz Wojtas, Andrzej Lewandowicz, Agata Michalak, Grzegorz Krasowski, Christoph H Borchers, Michal Dadlez, Dominik Domanski
PURPOSE: The goal of this work was to develop an LC-MRM assay for the quantitative analysis of a set of established and diagnostically important cytokeratin (CK) markers used in cancer diagnosis, prognosis and therapy monitoring. Secondly, the potential of this assay in lung cancer diagnosis through pleural effusion (PE) analysis was examined. EXPERIMENTAL DESIGN: A multiplexed MRM assay was developed for 17 CKs and their select caspase-cleaved fragments. Isotope-labeled standard peptides were used for high assay specificity and absolute peptide quantitation; with robust standard-flow LC coupled to a latest-generation triple-quadrupole instrument for high sensitivity...
January 19, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29352515/principles-of-alemtuzumab-immunoablation-in-hematopoietic-cell-transplantation-for-non-malignant-diseases-in-children-a-review
#10
REVIEW
Gregory M T Guilcher, Ravi Shah, Shalini Shenoy
Alemtuzumab is a humanized mAb targeted to CD52. Alemtuzumab is highly immunosuppressive with the ability to deplete T and B cells (in addition to other immune cell lines). A growing understanding of the PKs, dosing, and timing of administration of alemtuzumab has allowed for the study of its use as a conditioning agent for allogeneic HCT. The highly immunosuppressive properties of the drug are particularly appealing in the setting of non-malignant HCT, where GVHD provides no clinical benefit and relapse of malignancy is not applicable...
January 19, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29352368/endocrine-therapy-and-related-issues-in-hormone-receptor-positive-early-breast-cancer-a-roundtable-discussion-by-the-breast-cancer-therapy-expert-group-bcteg
#11
REVIEW
Jame Abraham, Humberto Caldera, Robert Coleman, Anthony Elias, Matthew P Goetz, Muaiad Kittaneh, Elyse Lower, Reshma Mahtani, E Terry Mamounas, Mark Pegram, Hope Rugo, Lee Schwartzberg, Tiffany Traina, Chuck Vogel
PURPOSE: Management of breast cancer is a rapidly evolving field, and, although evidence-based guidelines are available for clinicians to provide direction on critical issues in patient care, clinicians often left to address these issues in the context of community practice situations with their patients. These include the patient's comorbid conditions, actual versus perceived benefit of treatments, patient's compliance as well as financial/reimbursement issues, and long-term tolerability of therapy...
January 19, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29352350/groundwater-quality-assessment-in-semi-arid-regions-using-integrated-approaches-the-case-of-grombalia-aquifer-ne-tunisia
#12
Siwar Kammoun, Rim Trabelsi, Viviana Re, Kamel Zouari, Jihed Henchiri
As many arid and semi-arid regions in the Mediterranean Basin, the Grombalia coastal aquifer (NE Tunisia) is affected by severe groundwater exploitation and contamination. Therefore, quality assessments are becoming increasingly important as the long-term protection of water resources is at stake. Multidisciplinary investigations, like the one presented in this paper, are particularly effective in identifying the different origins of mineralization within an aquifer and investigating the impact of anthropogenic activities on groundwater quality...
January 19, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29352136/gphenovision-a-ground-mobile-system-with-multi-modal-imaging-for-field-based-high-throughput-phenotyping-of-cotton
#13
Yu Jiang, Changying Li, Jon S Robertson, Shangpeng Sun, Rui Xu, Andrew H Paterson
Imaging sensors can extend phenotyping capability, but they require a system to handle high-volume data. The overall goal of this study was to develop and evaluate a field-based high throughput phenotyping system accommodating high-resolution imagers. The system consisted of a high-clearance tractor and sensing and electrical systems. The sensing system was based on a distributed structure, integrating environmental sensors, real-time kinematic GPS, and multiple imaging sensors including RGB-D, thermal, and hyperspectral cameras...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352082/clostridial-strain-specific-characteristics-associated-with-necrotizing-enterocolitis
#14
Sophia Schönherr-Hellec, Geraldine L Klein, Johanne Delannoy, Laurent Ferraris, Jean Christophe Rozé, Marie José Butel, Julio Aires
We aimed at identifying potential clostridial factors linking these bacteria with necrotizing enterocolitis (NEC). We compared the phenotypic traits, stress responses, cellular cytotoxicity and inflammatory capabilities of the largest collection of Clostridium butyricum and Clostridium neonatale strains isolated from fecal samples of NEC and control preterm neonates (PN). When strains characteristics were used as explanatory variables, a statistical discriminant analysis allowed the separation of NEC and control strains into separate groups...
January 19, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29352053/two-doctors-one-patient-and-a-common-goal
#15
Chadi Nabhan, Jeremy Topin
No abstract text is available yet for this article.
January 19, 2018: Oncologist
https://www.readbyqxmd.com/read/29352052/estrogen-receptor-positive-breast-cancer-exploiting-signaling-pathways-implicated-in-endocrine-resistance
#16
REVIEW
Adam M Brufsky, Maura N Dickler
Advancements in molecular profiling and endocrine therapy (ET) have led to more focused clinical attention on precision medicine. These advances have expanded our understanding of breast cancer (BC) pathogenesis and hold promising implications for the future of therapy. The estrogen receptor-α is a predominant endocrine regulatory protein in the breast and in estrogen-induced BC. Successful targeting of proteins and genes within estrogen receptor (ER) nuclear and nonnuclear pathways remains a clinical goal...
January 19, 2018: Oncologist
https://www.readbyqxmd.com/read/29352005/differential-expression-of-cd8-t-cell-cytotoxic-effector-molecules-in-blood-and-gastrointestinal-mucosa-in-hiv-1-infection
#17
Brenna E Kiniry, Peter W Hunt, Frederick M Hecht, Ma Somsouk, Steven G Deeks, Barbara L Shacklett
We previously reported that CD8+ T cells in human gastrointestinal mucosa exhibit reduced perforin expression and weak or impaired cytotoxic capacity compared with their counterparts in blood. Nevertheless, these cells degranulate and express cytokines and chemokines in response to cognate Ag. In addition to weak expression of perforin, earlier studies suggested differential regulation of perforin and granzymes (Gzms), with GzmA and B expressed by significantly higher percentages of mucosal CD8+ T cells than perforin...
January 19, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29351922/activation-of-constitutive-androstane-receptor-ameliorates-renal-ischemia-reperfusion-induced-liver-and-kidney-injury
#18
You-Jin Choi, Dong Zhou, Anne Barbosa, Yongdong Niu, Xiudong Guan, Meishu Xu, Songrong Ren, Thomas Nolin, Yiuhua Liu, Wen Xie
Acute kidney injury (AKI) is associate with high mortality. Despite the evidence of AKI-induced distant organ injury, a relationship between AKI and liver injury has not been clearly established. The goal of this study is to investigate whether renal ischemia-reperfusion (IR) can affect liver pathophysiology. We showed that renal IR in mice induced fatty liver and compromised liver function through the down-regulation of constitutive androstane receptor (CAR; -90.4%) and inhibition of hepatic very low-density lipoprotein-triglyceride (VLDL-TG) secretion (-28...
January 19, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29351907/energy-connections-and-misconnections-across-chemistry-and-biology
#19
Kathryn P Kohn, Sonia M Underwood, Melanie M Cooper
Despite the number of university students who take courses in multiple science disciplines, little is known about how they connect concepts between disciplines. Energy is a concept that underlies all scientific phenomena and, as such, provides an appropriate context in which to investigate student connections and misconnections across disciplines. In this study, university students concurrently enrolled in introductory chemistry and biology were interviewed to explore their perceptions of the integration of energy both within and across the disciplines, and how they attempted to accommodate and reconcile different disciplinary approaches to energy, to inform future, interdisciplinary course reform...
2018: CBE Life Sciences Education
https://www.readbyqxmd.com/read/29351906/edc-impact-molecular-effects-of-developmental-fm-550-exposure-in-wistar-rat-placenta-and-fetal-forebrain
#20
Kylie R Baldwin, Brian Horman, Allison L Phillips, Susan L McRitchie, Scott Watson, Jocelin Deese-Spruill, Dereje Jima, Susan Sumner, Heather Stapleton, Heather Patisaul
Firemaster 550 (FM 550) is a flame retardant (FR) mixture that has become one of the most commonly used FRs in foam-based furniture and baby products. Human exposure to this commercial mixture, comprised of brominated and organophosphate components, is widespread. We have repeatedly shown that developmental exposure can lead to sex-specific behavioral effects in rats. Accruing evidence of endocrine disruption and potential neurotoxicity have raised concerns regarding the neurodevelopmental effects of FM 550 exposure, but the specific mechanisms of action remains unclear...
January 19, 2018: Endocrine Connections
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