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https://www.readbyqxmd.com/read/29769534/a-five-microrna-signature-for-survival-prognosis-in-pancreatic-adenocarcinoma-based-on-tcga-data
#1
Xiu-Hui Shi, Xu Li, Hang Zhang, Rui-Zhi He, Yan Zhao, Min Zhou, Shu-Tao Pan, Chun-Le Zhao, Ye-Chen Feng, Min Wang, Xing-Jun Guo, Ren-Yi Qin
Novel biomarkers for pancreatic adenocarcinoma are urgently needed because of its poor prognosis. Here, by using The Cancer Genome Atlas (TCGA) RNA-seq data, we evaluated the prognostic values of the differentially expressed miRNAs and constructed a five-miRNA signature that could effectively predict patient overall survival (OS). The Kaplan-Meier overall survival curves of two groups based on the five miRNAs were notably different, showing overall survival in 10.2% and 47.8% at five years for patients in high-risk and low-risk groups, respectively...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29766635/efficacy-and-safety-of-mk-1293-insulin-glargine-compared-with-originator-insulin-glargine-lantus-in-type-1-diabetes-a-randomized-open-label-clinical-trial
#2
Philip D Home, Raymond L H Lam, Wendy L Carofano, Gregory T Golm, Roy Eldor, Michael F Crutchlow, Michael C Marcos, Julio Rosenstock, Priscilla A Hollander, Baptist Gallwitz
AIMS: Comparison of the efficacy and safety of MK-1293 insulin glargine (Mk-Gla; 100 U/ml) with originator insulin glargine, Lantus (Sa-Gla) in people with type 1 diabetes mellitus (T1DM). MATERIALS AND METHODS: This phase 3, randomized, active-controlled, open-label, 52-week study enrolled 508 people with T1DM (HbA1c ≤ 11.0%; 97 mmol/mol) taking basal and prandial insulin. Participants were randomized 1:1 to once-daily Mk-Gla (n=245) or Sa-Gla (n=263). Dose titration of basal insulin was by a pre-breakfast plasma glucose dosing algorithm...
May 15, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29761615/efficacy-and-safety-of-mk-1293-insulin-glargine-compared-with-originator-insulin-glargine-lantus-in-type-2-diabetes-a-randomized-open-label-clinical-trial
#3
Priscilla A Hollander, Wendy L Carofano, Raymond L H Lam, Gregory T Golm, Roy Eldor, Michael F Crutchlow, Michael C Marcos, Marc S Rendell, Philip D Home, Baptist Gallwitz, Julio Rosenstock
AIMS: To compare the efficacy and safety of MK-1293 insulin glargine (Mk-Gla) and Lantus (Sa-Gla) in people with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: This Phase 3, randomized, active-controlled, open-label, 24-week clinical trial enrolled 531 participants with T2DM (HbA1c ≤11.0%) eligible for or currently taking basal insulin (≥10 U/day). Participants were randomized 1:1 to once-daily Mk-Gla (n=263) or Sa-Gla (n=263). Titration of insulin was guided by a fasting plasma glucose (FPG)-based dosing algorithm...
May 14, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29760154/maternal-exposure-to-ambient-particulate-matter-%C3%A2-2-5-%C3%A2%C2%B5m-during-pregnancy-and-the-risk-for-high-blood-pressure-in-childhood
#4
Mingyu Zhang, Noel T Mueller, Hongjian Wang, Xiumei Hong, Lawrence J Appel, Xiaobin Wang
Exposure to ambient air pollution has been associated with greater risk of elevated blood pressure (BP) in adults and children. Recent evidence suggests that air pollution exposure in pregnancy may also portend increased risk for the next generation; however, few studies have examined this relationship. We conducted a prospective study of 1293 mothers in the Boston Birth Cohort (enrolled 1998-2012) and their children who had follow-up visits between 3 and 9 years of age and complete exposure and outcome data...
May 14, 2018: Hypertension
https://www.readbyqxmd.com/read/29726399/diagnostic-dilemma-for-low-viremia-with-significant-fibrosis-is-hbv-dna-threshold-level-a-good-indicator-for-predicting-liver-damage
#5
Ercan Yenilmez, Rıza Aytaç Çetinkaya, Ersin Tural
BACKGROUND: The most important difficulties about management of hepatitis B are still determining the liver damage and the right time to start antiviral therapy. AIMS: To reveal the role of hepatitis B virus DNA threshold level for prediction of liver fibrosis and inflammation in young-aged hepatitis B e antigen negative chronic hepatitis B patients. STUDY DESIGN: Diagnostic accuracy study. METHODS: A total of 273 hepatitis B e antigen negative young chronic hepatitis B patients with any hepatitis B virus DNA levels between 2008 and 2016, who had liver biopsy after at least 6 months follow up period, enrolled in this retrospective study...
May 4, 2018: Balkan Medical Journal
https://www.readbyqxmd.com/read/29707127/risk-of-sexual-transmitted-infection-following-bipolar-disorder-a-nationwide-population-based-cohort-study
#6
Shyh-Chyang Lee, Chang-Kuo Hu, Jeng-Hsiu Hung, Albert C Yang, Shih-Jen Tsai, Min-Wei Huang, Li-Yu Hu, Cheng-Che Shen
Background: Bipolar disorder is a severe mental disorder associated with functional and cognitive impairment. Numerous studies have investigated associations between sexually transmitted infections (STIs) and psychiatric illnesses. However, the results of these studies are controversial. Objective: We explored the association between bipolar disorder and the subsequent development of STIs, including human immunodeficiency virus infection; primary, secondary, and latent syphilis; genital warts; gonorrhea; chlamydial infection; and trichomoniasis...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29668697/efficacy-and-safety-of-biosimilar-insulins-compared-to-their-reference-products-a-systematic-review
#7
Carolyn Tieu, Eleanor J Lucas, Mindi DePaola, Lori Rosman, G Caleb Alexander
IMPORTANCE: For nearly a century, no generic form of insulin has been available in the United States. However, the first biosimilar insulin, Basaglar, was approved by the U.S. Food and Drug Administration in 2015, and subsequently Admelog and Lusduna in 2017. OBJECTIVE: To summarize the scientific evidence comparing the safety, efficacy, pharmacokinetics, and pharmacodynamics of biosimilar and reference insulin products. DATA SOURCES: We conducted a systematic review using PubMed, Cochrane, Embase, Latin America and Caribbean Health Sciences, South Asian Database of Controlled Clinical Trials, and IndiaMED from their inception through January 14, 2018...
2018: PloS One
https://www.readbyqxmd.com/read/29660396/analysis-of-clinical-management-of-infected-breast-implants-and-of-factors-associated-to-successful-breast-pocket-salvage-in-infections-occurring-after-breast-reconstruction
#8
Simonetta Franchelli, Marianna Pesce, Ilaria Baldelli, Anna Marchese, Pierluigi Santi, Andrea De Maria
OBJECTIVES: Considerable efforts have been devoted so far to improve salvage procedures of infected breast implants in absence of defined guidelines or validated clinical protocols. Within a cohort of prospectively recruited patients who underwent breast reconstruction, we performed a retrospective review of proven implant infections in order to describe factors contributing to management success. METHODS: We collected data in 1293 consecutive patients who underwent two stage (expander+ prosthesis) breast reconstruction with at least 12 months of follow-up...
April 13, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29644086/is-recreational-running-associated-with-earlier-delivery-and-lower-birth-weight-in-women-who-continue-to-run-during-pregnancy-an-international-retrospective-cohort-study-of-running-habits-of-1293-female-runners-during-pregnancy
#9
Katy Kuhrt, Mark Harmon, Natasha L Hezelgrave, Paul T Seed, Andrew H Shennan
Background: Increasingly, women of reproductive age participate in recreational running, but its impact on pregnancy outcome is unknown. We investigated whether running affects gestational age at delivery and birth weight as indicators of cervical integrity and placental function, respectively. Methods: 1293 female participants were recruited from parkrun, which organises weekly runs involving 1.25 million runners across 450 parks worldwide. Those under 16 or unable to provide outcome data were excluded...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29617781/impact-of-counseling-received-by-adolescents-undergoing-voluntary-medical-male-circumcision-on-knowledge-and-sexual-intentions
#10
Michelle R Kaufman, Eshan U Patel, Kim H Dam, Zoe R Packman, Lynn M Van Lith, Karin Hatzold, Arik V Marcell, Webster Mavhu, Catherine Kahabuka, Lusanda Mahlasela, Emmanuel Njeuhmeli, Kim Seifert Ahanda, Getrude Ncube, Gissenge Lija, Collen Bonnecwe, Aaron A R Tobian
Background: Little is known regarding the impact of counseling delivered during voluntary medical male circumcision (VMMC) services on adolescents' human immunodeficiency virus (HIV) knowledge, VMMC knowledge, or post-VMMC preventive sexual intentions. This study assessed the effect of counseling on knowledge and intentions. Methods: Surveys were conducted with 1293 adolescent clients in 3 countries (South Africa, n = 299; Tanzania, n = 498; Zimbabwe, n = 496). Adolescents were assessed on HIV and VMMC knowledge-based items before receiving VMMC preprocedure counseling and at a follow-up survey approximately 10 days postprocedure...
April 3, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29617779/parental-communication-engagement-and-support-during-the-adolescent-voluntary-medical-male-circumcision-experience
#11
Kim H Dam, Michelle R Kaufman, Eshan U Patel, Lynn M Van Lith, Karin Hatzold, Arik V Marcell, Webster Mavhu, Catherine Kahabuka, Lusanda Mahlasela, Emmanuel Njeuhmeli, Kim Seifert Ahanda, Getrude Ncube, Gissenge Lija, Collen Bonnecwe, Aaron A R Tobian
Background: Voluntary medical male circumcision (VMMC) is one of few opportunities in sub-Saharan Africa to engage male adolescents in the healthcare system. Limited data are available on the level of parental communication, engagement, and support adolescents receive during the VMMC experience. Methods: We conducted 24 focus group discussions with parents/guardians of adolescents (N = 192) who agreed to be circumcised or were recently circumcised in South Africa, Tanzania, and Zimbabwe...
April 3, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29617777/adolescent-wound-care-self-efficacy-and-practices-after-voluntary-medical-male-circumcision-a-multicountry-assessment
#12
Webster Mavhu, Karin Hatzold, Kim H Dam, Michelle R Kaufman, Eshan U Patel, Lynn M Van Lith, Catherine Kahabuka, Arik V Marcell, Lusanda Mahlasela, Emmanuel Njeuhmeli, Kim Seifert Ahanda, Getrude Ncube, Gissenge Lija, Collen Bonnecwe, Aaron A R Tobian
Background: Adolescent boys (aged 10-19 years) constitute the majority of voluntary medical male circumcision (VMMC) clients in sub-Saharan Africa. They are at higher risk of postoperative infections compared to adults. We explored adolescents' wound-care knowledge, self-efficacy, and practices after VMMC to inform strategies for reducing the risks of infectious complications postoperatively. Methods: Quantitative and qualitative data were collected in South Africa, Tanzania, and Zimbabwe between June 2015 to September 2016...
April 3, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29617776/counseling-received-by-adolescents-undergoing-voluntary-medical-male-circumcision-moving-toward-age-equitable-comprehensive-human-immunodeficiency-virus-prevention-measures
#13
Michelle R Kaufman, Eshan U Patel, Kim H Dam, Zoe R Packman, Lynn M Van Lith, Karin Hatzold, Arik V Marcell, Webster Mavhu, Catherine Kahabuka, Lusanda Mahlasela, Emmanuel Njeuhmeli, Kim Seifert Ahanda, Getrude Ncube, Gissenge Lija, Collen Bonnecwe, Aaron A R Tobian
Background: The minimum package of voluntary medical male circumcision (VMMC) services, as defined by the World Health Organization, includes human immunodeficiency virus (HIV) testing, HIV prevention counseling, screening/treatment for sexually transmitted infections, condom promotion, and the VMMC procedure. The current study aimed to assess whether adolescents received these key elements. Methods: Quantitative surveys were conducted among male adolescents aged 10-19 years (n = 1293) seeking VMMC in South Africa, Tanzania, and Zimbabwe...
April 3, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29580351/short-and-long-term-results-of-laparoscopic-parenchyma-sparing-hepatectomy-for-small-sized-hepatocellular-carcinoma-a-comparative-study-using-propensity-score-matching-analysis
#14
Yoshihiro Inoue, Yusuke Suzuki, Masato Ota, Kensuke Fujii, Nao Kawaguchi, Fumitoshi Hirokawa, Michihiro Hayashi, Kazuhisa Uchiyama
The aim of this study was to evaluate the degree of invasiveness and the clinical outcomes of laparoscopic parenchyma-sparing hepatectomy (LPSH) for a maximum hepatocellular carcinoma (HCC) size ≤5 cm. Sixty-one LPSHs and 175 open parenchyma-sparing hepatectomies (OPSHs) for small-sized HCC were analyzed using a propensity score matching analysis. The median operative time was significantly shorter in the LPSH group (194 min) than in the OPSH group (275 minutes) (P < 0.0001). The estimated blood loss was significantly lower in the LPSH group (100 mL) than in the OPSH group (380 mL) (P < 0...
February 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29580225/psychotropic-medication-use-among-patients-with-celiac-disease
#15
Haley M Zylberberg, Jonas F Ludvigsson, Peter H R Green, Benjamin Lebwohl
BACKGROUND: Celiac disease is a multi-system disorder with manifestations that may result in psychiatric disorders. We assessed the prevalence of medication use to treat psychiatric disorders in celiac disease patients. METHODS: We conducted a cross-sectional study of patients undergoing esophagogastroduodenoscopy over 9-years at a celiac disease referral center. We compared the prevalence of psychotropic medication use among celiac disease patients (n = 1293) to a control group (n = 1401) with abdominal pain or reflux...
March 27, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29536603/biosimilar-vs-originator-insulins-systematic-review-and-meta-analysis
#16
Tomohide Yamada, Ryuichi Kamata, Kotomi Ishinohachi, Nobuhiro Shojima, Sophia Ananiadou, Hisashi Nom, Toshimasa Yamauchi, Takashi Kadowaki
Biosimilar insulins have expanded the treatment options for diabetes. We compared the clinical efficacy and safety of biosimilar insulins with those of originator insulins by conducting a meta-analysis. A random-effects meta-analysis was performed on randomized controlled trials comparing biosimilar and originator insulins in adults with diabetes. Studies were obtained by searching electronic databases up to December 2017. Ten trials, in a total of 4935 patients, were assessed (2 trials each on LY2963016, MK-1293, Mylan's insulin glargine and SAR342434, and 1 trial each on FFP-112 and Basalog)...
March 14, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29534105/dengue-virus-in-aedes-aegypti-and-aedes-albopictus-in-urban-areas-in-the-state-of-rio-grande-do-norte-brazil-importance-of-virological-and-entomological-surveillance
#17
Arlinete S Medeiros, Diego M P Costa, Mário S D Branco, Daíse M C Sousa, Joelma D Monteiro, Sílvio P M Galvão, Paulo Roberto M Azevedo, José V Fernandes, Selma M B Jeronimo, Josélio M G Araújo
BACKGROUND: Vector control remains the sole effective method to prevent dengue virus (DENV) transmission, although a vaccine for dengue has recently become available and testing of its efficacy and coverage is being performed in multiple places. Entomological surveillance is a key factor in alerting authorities to possible outbreaks, but until now natural DENV infection of mosquito populations has been scarcely used as an early warning system to monitor fluctuating prevalence of infected mosquitoes...
2018: PloS One
https://www.readbyqxmd.com/read/29530041/syrian-refugees-in-greece-experience-with-violence-mental-health-status-and-access-to-information-during-the-journey-and-while-in-greece
#18
Jihane Ben Farhat, Karl Blanchet, Pia Juul Bjertrup, Apostolos Veizis, Clément Perrin, Rebecca M Coulborn, Philippe Mayaud, Sandra Cohuet
BACKGROUND: Since 2015, Europe has been facing an unprecedented arrival of refugees and migrants: more than one million people entered via land and sea routes. During their travels, refugees and migrants often face harsh conditions, forced detention, and violence in transit countries. However, there is a lack of epidemiological quantitative evidence on their experiences and the mental health problems they face during their displacement. We aimed to document the types of violence experienced by migrants and refugees during their journey and while settled in Greece, and to measure the prevalence of anxiety disorders and access to legal information and procedures...
March 13, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29478080/fdg-pet-ct-for-treatment-response-assessment-in-head-and-neck-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis-of-diagnostic-performance
#19
REVIEW
Nils Helsen, Tim Van den Wyngaert, Laurens Carp, Sigrid Stroobants
PURPOSE: 18-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) is increasingly used to evaluate treatment response in head and neck squamous cell carcinoma (HNSCC). This analysis assessed the diagnostic value of FDG-PET/CT in detecting nodal disease within 6 months after treatment, considering patient and disease characteristics. METHODS: A systematic review was performed using the MEDLINE and Web of Knowledge databases...
June 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29395814/low-normal-fasting-glucose-and-risk-of-accidental-death-in-korean-adults-a-prospective-cohort-study
#20
S-W Yi, Y J Won, J-J Yi
AIM: This study aimed to prospectively examine whether low normal glucose levels and hypoglycaemia are associated with increased mortality due to external causes, especially unintentional accidents. METHODS: A total of 345,318 normoglycaemic Korean adults who had undergone health examinations during 2002-2003 were followed-up to 2013. To avoid potential biases related to glucose-lowering medication use, those with known diabetes or hyperglycaemia were excluded. RESULTS: During 3...
January 11, 2018: Diabetes & Metabolism
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