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https://www.readbyqxmd.com/read/28353580/comparison-of-periarticular-anesthesia-with-liposomal-bupivacaine-with-femoral-nerve-block-for-pain-control-after-total-knee-arthroplasty-a-prisma-compliant-meta-analysis
#1
COMPARATIVE STUDY
Shu-Qun Liu, Xiang Chen, Chen-Chen Yu, Cheng-Wei Weng, Yan-Qin Wu, Jun-Cheng Xiong, Shi-Hao Xu
BACKGROUND: Periarticular anesthesia (PAI) with liposomal bupivacaine (LB) and femoral nerve block (FNB) were 2 common type of pain management after total knee arthroplasty (TKA). There is no consensus about PAI with LB shows better clinical outcome than FNB. Thus, we performed a systematic review and meta-analysis to compare the efficacy and safety of PAI with LB and FNB for patients prepared for TKA. METHODS: Randomized controlled trials (RCTs) and non-RCTs from PubMed (1966-2017...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28338236/hsa-mir-3199-2-and-hsa-mir-1293-as-novel-prognostic-biomarkers-of-papillary-renal-cell-carcinoma-by-cox-ratio-risk-regression-model-screening
#2
Wen Luo, Lei Wang, Mao-Hua Luo, Yu-Zhu Huang, Hua Yang, Yu Zhou, Hong-Tao Jia, Xiu-Xin Wang
Papillary renal cell carcinoma(PRCC) is the second most common and aggressive renal cell carcinoma. Identification of novel microRNA biomarkers could be beneficial for the diagnosis and prognosis of PRCCpatients.We aimed to screen differentially expressed miRNAs that can act as prognostic factors and to predict the survival of PRCC patients. High-throughput data of miRNAs of 274 PRCC samples were downloaded from TCGA(The Cancer Genome Atlas) dataset and interested miRNAs were identified. Hierarchical clustering and principal component analysis (PCA) were performed on these miRNAs...
March 24, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28323715/the-safety-and-strength-of-a-novel-medial-partial-nonthreaded-pedicle-screw-a-cadaveric-and-biomechanical-investigation
#3
Mun Keong Kwan, Chris Yin Wei Chan, Lim Beng Saw, Shanmugam Rukmanikanthan, Lawrence G Lenke
STUDY DESIGN: Cadaveric and biomechanical study. OBJECTIVE: The aim of this study was to assess the safety and pullout strength of medial, partial nonthreaded thoracic pedicle screws compared with conventional screws. SUMMARY OF BACKGROUND DATA: The perforation rate of the pedicle screws has been reported as high as 41%. Nerve injury and irritation can result from the compression of malpositioned screw on neural structures. METHODS: Ten fresh cadavers were studied...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28316039/public-health-data-in-action-an-analysis-of-using-louisiana-vital-statistics-for-quality-improvement-and-payment-reform
#4
Valery A Danilack, Rebekah E Gee, Danielle P Berthelot, Rebecca Gurvich, Janet H Muri
Introduction In 2012, the Louisiana (LA) Department of Health and Hospitals revised the LA birth certificate to include medical reasons for births before 39 completed weeks' gestation. We compared the completeness and validity of these data with hospital discharge records. Methods For births occurring 4/1/2012-9/30/2012 at Woman's Hospital of Baton Rouge, we linked maternal delivery and newborn birth data collected through the National Perinatal Information Center with LA birth certificates. Among early term births (37-38 completed weeks' gestation), we quantified the reasons for early delivery listed on the birth certificate and compared them with ICD-9-CM codes from Woman's discharge data...
March 18, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28294506/changes-in-management-policies-for-extremely-preterm-births-and-neonatal-outcomes-from-2003-to-2012-two-population-based-studies-in-10-european-regions
#5
M Bonet, M Cuttini, A Piedvache, E M Boyle, P H Jarreau, L Kollée, R F Maier, D W A Milligan, P Van Reempts, T Weber, H Barros, J Gadzinowki, E S Draper, J Zeitlin
OBJECTIVE: to investigate changes in maternity and neonatal unit policies towards extremely preterm infants (EPTI) between 2003 and 2012 and concurrent trends in their mortality and morbidity in ten European regions. DESIGN: population-based cohort studies in 2003 (MOSAIC study) and 2011/12 (EPICE study) and questionnaires from hospitals. SETTING: 70 hospitals in ten European regions. POPULATION: infants born at <27 weeks of gestational age (GA) in hospitals participating in both the MOSAIC and EPICE studies (1240 in 2003, 1293 in 2011/2012)...
March 14, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28291646/does-seasonal-vaccination-affect-the-clinical-presentation-of-influenza-among-the-elderly-a-cross-sectional-analysis-in-the-outpatient-setting-in-france-2003-2014
#6
Anne Mosnier, Isabelle Daviaud, Saverio Caini, Hervé Berche, Jean-Michel Mansuy, Sylvie van der Werf, Jean Marie Cohen, Bruno Lina
Vaccine-induced protection against influenza is not optimal, however it has been suggested that the vaccine may reduce the severity of symptoms among those who develop illness despite being vaccinated. We tested this hypothesis within a countrywide, sentinel general practitioners-based surveillance system in France. We included 2277 individuals aged 65years or older (of whom 1293 had been vaccinated against influenza, 56.8%) who consulted a general practitioner because of an acute respiratory infection (ARI) during 2003-2014...
March 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28208462/beyond-flory-theory-distribution-functions-for-interacting-lattice-trees
#7
Angelo Rosa, Ralf Everaers
While Flory theories [J. Isaacson and T. C. Lubensky, J. Physique Lett. 41, 469 (1980)JPSLBO0302-072X10.1051/jphyslet:019800041019046900; M. Daoud and J. F. Joanny, J. Physique 42, 1359 (1981)JOPQAG0302-073810.1051/jphys:0198100420100135900; A. M. Gutin et al., Macromolecules 26, 1293 (1993)MAMOBX0024-929710.1021/ma00058a016] provide an extremely useful framework for understanding the behavior of interacting, randomly branching polymers, the approach is inherently limited. Here we use a combination of scaling arguments and computer simulations to go beyond a Gaussian description...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28045549/curcumin-and-viscum-album-extract-decrease-proliferation-and-cell-viability-of-soft-tissue-sarcoma-cells-an-in-vitro-analysis-of-eight-cell-lines-using-real-time-monitoring-and-colorimetric-assays
#8
K Harati, B Behr, A Daigeler, T Hirsch, F Jacobsen, M Renner, A Harati, C Wallner, M Lehnhardt, M Becerikli
BACKGROUND: The cytostatic effects of the polyphenol curcumin and Viscum album extract (VAE) were assessed in soft-tissue sarcoma (STS) cells. METHODS: Eight human STS cell lines were used: fibrosarcoma (HT1080), liposarcoma (SW872, T778, MLS-402), synovial sarcoma (SW982, SYO1, 1273), and malignant fibrous histiocytoma (U2197). Primary human fibroblasts served as control cells. Cell proliferation, viability, and cell index (CI) were analyzed by BrdU assay, MTT assay, and real-time cell analysis (RTCA)...
January 3, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/27999051/pharmacokinetic-interactions-between-cobicistat-boosted-elvitegravir-and-darunavir-in-hiv-infected-patients
#9
Alicia Gutierrez-Valencia, Omar J Benmarzouk-Hidalgo, Silvia Llaves, Tamara Fernandez-Magdaleno, Nuria Espinosa, Pompeyo Viciana, Luis F Lopez-Cortes
Objectives: To evaluate if there are significant drug-drug interactions between cobicistat-boosted elvitegravir and 800 mg darunavir once daily taken simultaneously, as has been suggested previously. Methods: The study population consisted of three groups of unselected volunteers taking a regimen of elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil fumarate (150, 150, 200 and 300 mg, respectively) co-formulated in a single tablet plus 800 mg darunavir (group A); only co-formulated elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil fumarate (group B); and cobicistat-boosted darunavir (800 mg darunavir + 150 mg cobicistat) plus two nucleos(t)ide analogues (group C)...
March 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27987356/the-impact-of-admission-neutrophil-to-platelet-ratio-on-in-hospital-and-long-term-mortality-in-patients-with-infective-endocarditis
#10
Xue-Biao Wei, Yuan-Hui Liu, Peng-Cheng He, Dan-Qing Yu, Ning Tan, Ying-Ling Zhou, Ji-Yan Chen
BACKGROUND: Infective endocarditis (IE) is associated with increased neutrophil and reduced platelet counts. We assessed the relationship between the neutrophil-to-platelet ratio (NPR) on admission and adverse outcomes in patients with IE. METHODS: Patients diagnosed with IE between January 2009 and July 2015 (n=1293) were enrolled, and 1046 were finally entered into the study. Study subjects were categorized into four groups according to NPR quartiles: Q1<18...
December 17, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27908845/design-response-rates-and-population-characteristics-of-a-cross-sectional-study-in-zanzibar-tanzania
#11
Maria Adam Nyangasa, Soerge Kelm, Mohammed Ali Sheikh, Antje Hebestreit
BACKGROUND: Data on nutritional status and correlates of noncommunicable diseases are scarce for resource-poor settings in sub-Saharan countries. With the scope of a project, "Access to Food and Nutrition Status of the Zanzibari Population," data for investigating public health questions were collected using proven measurement and laboratory standards. OBJECTIVE: The present study aims at providing a descriptive overview of recruitment approaches, standardization, quality control measures, and data collection, with special attention to the design, responses, and participant characteristics of the overall project...
December 1, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27881251/comparison-of-health-care-utilization-and-costs-for-patients-with-asthma-by-severity-and-health-insurance-in-thailand
#12
Piyameth Dilokthornsakul, Todd A Lee, Teerapon Dhippayom, Napawan Jeanpeerapong, Nathorn Chaiyakunapruk
BACKGROUND: To compare health care utilization and cost by asthma severity and type of health insurance in Thailand. METHODS: A retrospective cohort study using an electronic database was conducted in patients with asthma. Patients who were diagnosed with asthma from 2009 to 2011, had at least two subsequent health care encounters for asthma during the first six months after the first asthma diagnosis, and had at least 90 days of follow-up were included. The primary outcome was direct health care costs of inpatient and outpatient care...
May 2016: Value in Health Regional Issues
https://www.readbyqxmd.com/read/27850929/1293-effect-of-continuous-venovenous-hemodiafiltration-on-amino-acid-delivery-and-clearance-in-children
#13
Richard Lion, Molly Vega, Michael Braun, Moreshwar Desai, Sridevi Deveraj, O'Brian Smith, Ayse Akcan-Arikan
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27776142/menstrual-and-reproductive-factors-and-risk-of-gastric-and-colorectal-cancer-in-spain
#14
Virginia Lope, Nerea Fernández de Larrea, Beatriz Pérez-Gómez, Vicente Martín, Victor Moreno, Laura Costas, Federico Longo, José Juan Jiménez-Moleón, Javier Llorca, Nieves Ascunce, Rosana Peiró-Pérez, Jone M Altzibar, Adonina Tardón, Juan Alguacil, Carmen Navarro, Ángeles Sierra, Ana Belén Vega, Amaya Villafañe, Gemma Castaño-Vinyals, Manolis Kogevinas, Marina Pollán, Nuria Aragonés
BACKGROUND: Sex hormones play a role in gastric cancer and colorectal cancer etiology, however, epidemiological evidence is inconsistent. This study examines the influence of menstrual and reproductive factors over the risk of both tumors. METHODS: In this case-control study 128 women with gastric cancer and 1293 controls, as well as 562 female and colorectal cancer cases and 1605 controls were recruited in 9 and 11 Spanish provinces, respectively. Population controls were frequency matched to cases by age and province...
2016: PloS One
https://www.readbyqxmd.com/read/27743172/time-trends-of-mortality-in-patients-with-non-functioning-pituitary-adenoma-a-swedish-nationwide-study
#15
Daniel S Olsson, Ing-Liss Bryngelsson, Oskar Ragnarsson
PURPOSE: Patients with non-functioning pituitary adenomas (NFPA), especially women, have increased mortality. The aim of this study was to investigate whether mortality in NFPA patients has changed during the last two decades. METHODS: This was a nationwide population-based study including 2795 patients (1502 men, 1293 women) diagnosed with NFPA between 1997 and 2011. Patients were identified and followed in Swedish National Health Registries. Standardized mortality ratios (SMRs) with 95 % confidence intervals were calculated for three time periods at first NFPA diagnosis using the general population as reference...
April 2017: Pituitary
https://www.readbyqxmd.com/read/27697388/a-comparison-of-radial-and-femoral-coronary-angiography-in-patients-from-snapshot-acs-a-prospective-acute-coronary-syndrome-audit-in-australia-and-new-zealand
#16
Mitchell Brooks, Chris Ellis, Greg Gamble, Gerry Devlin, John Elliott, Chris Hammett, Derek Chew, John French, Tom Briffa, Julie Redfern, Jamie Rankin, Karice Hyun, Mario D'Souza, David Brieger
BACKGROUND: There is wide variation in the use of radial over femoral access for patients with ACS. This study evaluates the factors associated with the selection of radial versus femoral angiography in Australia and New Zealand and the effect of access site on clinical events in acute coronary syndrome (ACS) patients. METHODS: An analysis of the SNAPSHOT ACS audit was conducted during May 2012 across 286 hospitals in Australia and New Zealand. Data collected included baseline patient characteristics, hospital site details, treatment received, clinical events in-hospital and mortality at 18 months...
August 22, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27693937/pelvic-floor-assessment-after-delivery-how-should-women-be-selected
#17
Marco Soligo, Stefania Livio, Elena De Ponti, Ileana Scebba, Federica Carpentieri, Maurizio Serati, Enrico Ferrazzi
OBJECTIVE: Pelvic floor dysfunction after delivery is quite common. New mothers deserve to receive targeted care for pelvic floor dysfunction, but how should women who are at risk be identified and selected for treatment? This study investigated risk factors and puerperal health-seeking behaviours to develop a restrictive patient selection model for postpartum pelvic floor dysfunction assessment. STUDY DESIGN: This prospective observational study involved women who were at ≥32 weeks gestational age when they delivered in a tertiary referral maternity hospital in Milan, Italy, between July and December 2014...
November 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27693279/-ischemia-reperfusion-preservation-solution-and-hypothermic-machine-perfusion
#18
B Barrou, N Chatauret, T Hauet, R Thuret, F Kleinclauss, M-O Timsit, R Codas, X Matillon, L Badet
AIMS: To describe ischemia-reperfusion mechanisms, the impact on kidney graft and strategies developed to minimize ischemia-reperfusion damages. MATERIAL AND METHODS: An exhaustive systematic review of the scientific literature was performed in the Medline database (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com) using different associations of the following keywords: ischemia-reperfusion; organ preservation; hypothermic machine perfusion; renal transplantation...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27660999/a-tri-nucleotide-pattern-in-a-3-utr-segment-affects-the-activity-of-a-human-glucocorticoid-receptor-isoform
#19
Tajia L Green, Stacey M Leventhal, Debora Lim, Kiho Cho, David G Greenhalgh
We previously identified a truncated human glucocorticoid receptor (hGR) isoform of 118 amino acids, hGR-S1(-349A), that despite lacking the major functional domains, was more hyperactive after glucocorticoid treatment than the full-length receptor. Furthermore, its 3' untranslated region (UTR) was required. To dissect the underlying mechanisms for hyperactivity, a series of hGR isoforms with consecutive deletions in the 3' UTR were created to test their transactivation potential using reporter assays. The hGR-S1(-349A) isoform retaining 1303 bp of 3' UTR displayed unusually high activity with or without glucocorticoid stimulation...
February 2017: Shock
https://www.readbyqxmd.com/read/27633869/novel-cardiac-nuclear-magnetic-resonance-method%C3%A2-for-noninvasive-assessment-of-myocardial%C3%A2-fibrosis-in-hemodialysis-patients
#20
Matthew P M Graham-Brown, Daniel S March, Darren R Churchward, David J Stensel, Anvesha Singh, Ranjit Arnold, James O Burton, Gerry P McCann
Left ventricular hypertrophy and myocardial fibrosis frequently occur in patients with end-stage renal disease receiving hemodialysis therapy and are associated with poor prognosis. Native T1 mapping is a novel cardiac magnetic resonance imaging technique that measures native myocardial T1 relaxation, a surrogate of myocardial fibrosis. Here we compared global and segmental native myocardial T1 time and global longitudinal, circumferential and segmental strain, and cardiac function of 35 hemodialysis patients and 22 control individuals...
October 2016: Kidney International
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