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https://www.readbyqxmd.com/read/29284542/a-comparison-of-two-emergency-medical-dispatch-protocols-with-respect-to-accuracy
#1
Klara Torlén, Lisa Kurland, Maaret Castrén, Knut Olanders, Katarina Bohm
BACKGROUND: Emergency medical dispatching should be as accurate as possible in order to ensure patient safety and optimize the use of ambulance resources. This study aimed to compare the accuracy, measured as priority level, between two Swedish dispatch protocols - the three-graded priority protocol Medical Index and a newly developed prototype, the four-graded priority protocol, RETTS-A. METHODS: A simulation study was carried out at the Emergency Medical Communication Centre (EMCC) in Stockholm, Sweden, between October and March 2016...
December 29, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29204597/association-of-overlapping-surgery-with-increased-risk-for-complications-following-hip-surgery-a-population-based-matched-cohort-study
#2
Bheeshma Ravi, Daniel Pincus, David Wasserstein, Anand Govindarajan, Anjie Huang, Peter C Austin, Richard Jenkinson, Patrick D G Henry, J Michael Paterson, Hans J Kreder
Importance: Overlapping surgery, also known as double-booking, refers to a controversial practice in which a single attending surgeon supervises 2 or more operations, in different operating rooms, at the same time. Objective: To determine if overlapping surgery is associated with greater risk for complications following surgical treatment for hip fracture and arthritis. Design, Setting, and Participants: This was a retrospective population-based cohort study in Ontario, Canada (population, 13...
January 1, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29190082/pourbaix-diagram-proton-coupled-electron-transfer-and-decay-kinetics-of-a-protein-tryptophan-radical-comparing-the-redox-properties-of-w32%C3%A2-and-y32%C3%A2-generated-inside-the-structurally-characterized-%C3%AE-3w-and-%C3%AE-3y-proteins
#3
Starla D Glover, Robin Tyburski, Li Liang, Cecilia Tommos, Leif Hammarström
Protein "hole" hopping typically involves spatially arranged redox-active tryptophan and/or tyrosine residues. Thermodynamic information is scarce for this type of process. The well-structured α3W model protein was studied by protein film square wave voltammetry and transient absorption spectroscopy to obtain a comprehensive thermodynamic and kinetic description of a buried tryptophan residue. A Pourbaix diagram, correlating thermodynamic potentials (E°') with pH, is reported for W32 in α3W and compared to equivalent data recently presented for Y32 in α3Y (Ravichandran, K...
November 30, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29187807/characteristic-mirna-expression-signature-and-random-forest-survival-analysis-identify-potential-cancer-driving-mirnas-in-a-broad-range-of-head-and-neck-squamous-cell-carcinoma-subtypes
#4
Yury O Nunez Lopez, Berta Victoria, Pawel Golusinski, Wojciech Golusinski, Michal M Masternak
Aim: To characterize the miRNA expression profile in head and neck squamous cell carcinoma (HNSSC) accounting for a broad range of cancer subtypes and consequently identify an optimal miRNA signature with prognostic value. Background: HNSCC is consistently among the most common cancers worldwide. Its mortality rate is about 50% because of the characteristic aggressive behavior of these cancers and the prevalent late diagnosis. The heterogeneity of the disease has hampered the development of robust prognostic tools with broad clinical utility...
January 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29180538/prevalence-and-sociodemographic-correlates-of-cervicovaginal-human-papillomavirus-hpv-carriage-in-a-cross-sectional-multiethnic-community-based-female-asian-population
#5
Su Pei Khoo, Nirmala Bhoo-Pathy, Siew Hwei Yap, Mohd Khairul Anwar Shafii, Nazrilla Hairizan Nasir, Jerome Belinson, ShriDevi Subramaniam, Pik Pin Goh, Ming Zeng, Hong Dong Tan, Patti Gravitt, Yin Ling Woo
OBJECTIVES: Cervical cancer is a largely preventable disease, and the strategic implementation of a cervical cancer prevention programme is partly dependent on the impact of human papillomavirus (HPV) infection interpreted within the context of the country's sociodemographic attributes. The objective of this study is to determine the prevalence of cervicovaginal HPV infection among a healthy, community-based, multiethnic Malaysian population. The HPV prevalence was subsequently correlated to the individual's sociodemographics and sexual/reproductive history...
November 27, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29177467/true-pathogen-or-contamination-validation-of-blood-cultures-for-the-diagnosis-of-nosocomial-infections-in-a-developing-country
#6
Indah K Murni, Trevor Duke, Andrew J Daley, Sharon Kinney, Yati Soenarto
Background: Blood culture results are frequently used to guide antibiotic decision-making, but culture contaminants need to be distinguished from true pathogens. Aims: To assess the contamination rate of blood cultures and validate a method to distinguish between true bacteraemia and contamination. Methods: We analysed blood culture results from children who were admitted to the paediatric ICU and paediatric wards at the Sardjito Hospital, Yogyakarta, Indonesia between December 2010 and February 2013...
November 21, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29176816/a-large-outbreak-of-hepatitis-e-virus-genotype-1-infection-in-an-urban-setting-in-chad-likely-linked-to-household-level-transmission-factors-2016-2017
#7
Alexander Spina, Annick Lenglet, David Beversluis, Marja de Jong, Larissa Vernier, Craig Spencer, Fred Andayi, Charity Kamau, Simone Vollmer, Boris Hogema, Andrea Irwin, Roger Ngueremi Yary, Açyl Mahamat Ali, Ali Moussa, Prince Alfani, Sibylle Sang
BACKGROUND: In September 2016, three acutely jaundiced (AJS) pregnant women were admitted to Am Timan Hospital, eastern Chad. We described the outbreak and conducted a case test-negative study to identify risk factors for this genotype of HEV in an acute outbreak setting. METHODS: Active case finding using a community based surveillance network identified suspected AJS cases. Pregnant or visibly ill AJS cases presenting at hospital were tested with Assure® IgM HEV rapid diagnostic tests (RDTs) and some with Polymerase Chain Reaction (PCR) in Amsterdam; confirmed cases were RDT-positive and controls were RDT-negative...
2017: PloS One
https://www.readbyqxmd.com/read/29158689/assessment-of-chronic-pain-and-access-to-pain-therapy-a-cross-sectional-population-based-study
#8
Rosaria Del Giorno, Paolo Frumento, Giustino Varrassi, Antonella Paladini, Stefano Coaccioli
Background: Chronic pain (CP) has been shown as an important public health problem, and several studies emphasize the need to strengthen the health care and social systems to reduce its marginalization. This study aimed to: evaluate the epidemiology of CP in the general population in an Italian area; and assess the awareness of a specific law, unanimously approved in Parliament, which provides citizens the right to access pain management (Italian Law 38/2010). Methods: A cross-sectional population-based study carried out during the spring of 2014 at Narni, Umbria, Italy...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29154801/human-small-bowel-as-a-useful-tool-to-investigate-smooth-muscle-effects-of-potential-therapeutics-in-organophosphate-poisoning
#9
Katharina Marquart, Olga Prokopchuk, Franz Worek, Horst Thiermann, Marc E Martignoni, Timo Wille
Isolated organs proofed to be a robust tool to study effects of (potential) therapeutics in organophosphate poisoning. Small bowel samples have been successfully used to reveal smooth muscle relaxing effects. In the present study, the effects of obidoxime, TMB-4, HI-6 and MB 327 were investigated on human small bowel tissue and compared with rat data. Hereby, the substances were tested in at least seven different concentrations in the jejunum or ileum both pre-contracted with carbamoylcholine. Additionally, the cholinesterase activity of native tissue was determined...
November 14, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29150811/alk-expression-plays-different-roles-in-anaplastic-large-cell-lymphomas-and-outcome-of-crizotinib-use-in-relapsed-refractory-alk-patients-in-a-chinese-population
#10
Ling Huang, Fen Zhang, Jialong Zeng, Hanguo Guo, Sichu Liu, Xiaojuan Wei, Feili Chen, Xinmiao Jiang, Zhanli Liang, Yanhui Liu, Wenyu Li
The prognostic value of anaplastic lymphoma kinase (ALK) expression in patients with anaplastic large-cell lymphoma (ALCL) remains controversial. Data on the clinical features of ALCL in a Chinese population are limited. We retrospectively reviewed 1293 patients with pathologically diagnosed lymphoma at Guangdong General Hospital from June 2007 through August 2016. We evaluated the incidence of ALCL, clinical characteristics, survival status, and outcome of crizotinib use in four relapsed/refractory ALK-positive patients...
November 17, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29142238/mapping-qtls-conferring-salt-tolerance-and-micronutrient-concentrations-at-seedling-stagein-wheat
#11
Babar Hussain, Stuart James Lucas, Levent Ozturk, Hikmet Budak
Soil salinization and degradation is one of the consequences of climate change. Identification of major salt tolerance genes and marker assisted selection (MAS) can accelerate wheat breeding for this trait. We genotyped 154 wheat F2 lines derived from a cross between salt tolerant and susceptible cultivars using the Axiom Wheat Breeder's Genotyping Array. A high-density linkage map of 988 single nucleotide polymorphisms (SNPs) was constructed and utilized for quantitative trait loci (QTL) mapping for salt tolerance traits and mineral concentrations under salinity...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29115287/consumer-product-chemical-weight-fractions-from-ingredient-lists
#12
Kristin K Isaacs, Katherine A Phillips, Derya Biryol, Kathie L Dionisio, Paul S Price
Assessing human exposures to chemicals in consumer products requires composition information. However, comprehensive composition data for products in commerce are not generally available. Many consumer products have reported ingredient lists that are constructed using specific guidelines. A probabilistic model was developed to estimate quantitative weight fraction (WF) values that are consistent with the rank of an ingredient in the list, the number of reported ingredients, and labeling rules. The model provides the mean, median, and 95% upper and lower confidence limit WFs for ingredients of any rank in lists of any length...
November 8, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/29072961/reducing-smoking-in-the-us-federal-workforce-5-year-health-and-economic-impacts-from-improved-cardiovascular-disease-outcomes
#13
Garrett R Beeler Asay, David M Homa, Erin M Abramsohn, Xin Xu, Erin L O'Connor, Guijing Wang
OBJECTIVE: We estimated the reduction in number of hospitalizations for acute myocardial infarction and stroke as well as the associated health care costs resulting from reducing the number of smokers in the US federal workforce during a 5-year period. METHODS: We developed a 5-year spreadsheet-based cohort model with parameter values from past literature and analysis of national survey data. We obtained 2015 data on the federal workforce population from the US Office of Personnel Management and data on smoking prevalence among federal workers from the 2013-2015 National Health Interview Survey...
November 2017: Public Health Reports
https://www.readbyqxmd.com/read/29027009/lipid-lowering-agent-triggered-dermatomyositis-and-polymyositis-a-case-series-and-literature-review
#14
REVIEW
Isabela Bruna Pires Borges, Marilda Guimarães Silva, Rafael Giovane Misse, Samuel Katsuyuki Shinjo
Lipid-lowering agent-triggered dermatomyositis (DM) or polymyositis (PM) is a rare event. Therefore, the aim of the present study was to describe a series of such cases. A retrospective cohort study of 5 DM and 4 PM cases triggered by prior exposure to lipid-lowering agents between 2001 and 2017 was carried out. All patients, except for two cases, had muscle biopsy compatible with inflammatory myopathy and no serum autoantibodies positive for anti-SRP or anti-HMGCoAR. Median age of the patients at time of diagnosis was 68 years...
October 12, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28973646/is-there-a-preoperative-morphine-equianalgesic-dose-that-predicts-ability-to-achieve-a-clinically-meaningful-improvement-following-spine-surgery
#15
Joseph B Wick, Ahilan Sivaganesan, Silky Chotai, Kristin R Archer, Samuel L Posey, Parker T Evans, Joel R Campbell, Clinton J Devin
BACKGROUND: Preoperative opioid use is widespread and associated with worse patient-reported outcomes following spine surgery. OBJECTIVE: To calculate a threshold preoperative morphine equianalgesic (MEA) dose beyond which patients are less likely to achieve the minimum clinically important difference (MCID) following elective surgery for degenerative spine disease. METHODS: The study included 543 cervical and 1293 lumbar patients. Neck Disability Index and Oswestry Disability Index scores were collected at baseline and 12 mo postoperatively...
July 25, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28962835/identification-and-validation-of-the-microrna-response-elements-in-the-3-untranslated-region-of-the-udp-glucuronosyltransferase-ugt-2b7-and-2b15-genes-by-a-functional-genomics-approach
#16
Ioannis Papageorgiou, Michael H Court
Posttranscriptional repression of UDP-glucuronosyltransferase (UGT) 2B7 and 2B15 expression by microRNAs (miRNAs) may be an important mechanism underlying inter-individual variability in drug glucuronidation. Furthermore, the UGT2B15 3'-UTR contains a common SNP (rs3100) that could influence miRNA binding. The aim of this study was to identify the complete complement of miRNAs that could regulate UGT2B7 and UGT2B15 expression through binding to the reference and/or variant 3'-UTRs. Luciferase reporter plasmids containing either the reference or variant 3'-UTRs were screened against a 2,048 human miRNA library to identify those miRNAs that decrease luciferase activity by at least 30% when co-transfected into HEK293 cells...
September 28, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28944954/multicentre-cohort-study-to-define-and-validate-pathological-assessment-of-response-to-neoadjuvant-therapy-in-oesophagogastric-adenocarcinoma
#17
MULTICENTER STUDY
F Noble, M A Lloyd, R Turkington, E Griffiths, M O'Donovan, J R O'Neill, S Mercer, S L Parsons, R C Fitzgerald, T J Underwood
BACKGROUND: This multicentre cohort study sought to define a robust pathological indicator of clinically meaningful response to neoadjuvant chemotherapy in oesophageal adenocarcinoma. METHODS: A questionnaire was distributed to 11 UK upper gastrointestinal cancer centres to determine the use of assessment of response to neoadjuvant chemotherapy. Records of consecutive patients undergoing oesophagogastric resection at seven centres between January 2000 and December 2013 were reviewed...
December 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28873137/association-between-more-intensive-vs-less-intensive-blood-pressure-lowering-and-risk-of-mortality-in-chronic-kidney-disease-stages-3-to-5-a-systematic-review-and-meta-analysis
#18
REVIEW
Rakesh Malhotra, Hoang Anh Nguyen, Oscar Benavente, Mihriye Mete, Barbara V Howard, Jonathan Mant, Michelle C Odden, Carmen A Peralta, Alfred K Cheung, Girish N Nadkarni, Ruth L Coleman, Rury R Holman, Alberto Zanchetti, Ruth Peters, Nigel Beckett, Jan A Staessen, Joachim H Ix
Importance: Trials in patients with hypertension have demonstrated that intensive blood pressure (BP) lowering reduces the risk of cardiovascular disease and all-cause mortality but may increase the risk of chronic kidney disease (CKD) incidence and progression. Whether intensive BP lowering is associated with a mortality benefit in patients with prevalent CKD remains unknown. Objectives: To conduct a systematic review and meta-analysis of randomized clinical trials (RCTs) to investigate if more intensive compared with less intensive BP control is associated with reduced mortality risk in persons with CKD stages 3 to 5...
October 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28846865/insulin-glargine-and-its-two-active-metabolites-a-sensitive-16pm-and-robust-simultaneous-hybrid-assay-coupling-immunoaffinity-purification-with-lc-ms-ms-to-support-biosimilar-clinical-studies
#19
Yang Xu, Li Sun, Melanie Anderson, Philippe Bélanger, Vincent Trinh, Patricia Lavallée, Bhavna Kantesaria, Marie-Josée Marcoux, Sheila Breidinger, Kevin P Bateman, Dina Goykhman, Eric J Woolf
MK-1293 is a newly approved follow-on/biosimilar insulin glargine for the treatment of Type 1 and Type 2 diabetics. To support pivotal clinical studies during biosimilar evaluation, a sensitive, specific and robust liquid chromatography and tandem mass spectrometry (LC-MS/MS) assay for the simultaneous quantification of glargine and its two active metabolites, M1 and M2 were developed. Strategies to overcome analytical challenges, so as to optimize assay sensitivity and improve ruggedness, were evolved, resulting in a fully validated LC-MS/MS method with a lower limit of quantification (LLOQ) at 0...
September 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28817223/single-dose-euglycemic-clamp-studies-demonstrating-pharmacokinetic-and-pharmacodynamic-similarity-between-mk-1293-insulin-glargine-and-originator-insulin-glargine-lantus-in-type-1-diabetes-and-healthy-subjects
#20
Michael Crutchlow, John S Palcza, Kate M Mostoller, Chantal D Mahon, April M Barbour, Michael C Marcos, Yang Xu, Elaine Watkins, Linda Morrow, Marcus Hompesch
AIMS: MK-1293 is an insulin glargine that has an identical amino acid sequence to that of Lantus, the originator insulin glargine. Two euglycemic clamp studies, one in subjects with Type 1 diabetes (T1D) and one in healthy subjects, were conducted to demonstrate pharmacokinetic (PK) and pharmacodynamic (PD) similarity between MK-1293 and Lantus commercially procured in both the European Union (EU-Lantus) and United States (US-Lantus). MATERIALS AND METHODS: Both studies were single-dose, randomized, double-blind, single-center, crossover studies with ≥7 days between dosing periods...
August 17, 2017: Diabetes, Obesity & Metabolism
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