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Virginia Lope, Nerea Fernández de Larrea, Beatriz Pérez-Gómez, Vicente Martín, Victor Moreno, Laura Costas, Federico Longo, José Juan Jiménez-Moleón, Javier Llorca, Nieves Ascunce, Rosana Peiró-Pérez, Jone M Altzibar, Adonina Tardón, Juan Alguacil, Carmen Navarro, Ángeles Sierra, Ana Belén Vega, Amaya Villafañe, Gemma Castaño-Vinyals, Manolis Kogevinas, Marina Pollán, Nuria Aragonés
BACKGROUND: Sex hormones play a role in gastric cancer and colorectal cancer etiology, however, epidemiological evidence is inconsistent. This study examines the influence of menstrual and reproductive factors over the risk of both tumors. METHODS: In this case-control study 128 women with gastric cancer and 1293 controls, as well as 562 female and colorectal cancer cases and 1605 controls were recruited in 9 and 11 Spanish provinces, respectively. Population controls were frequency matched to cases by age and province...
2016: PloS One
Daniel S Olsson, Ing-Liss Bryngelsson, Oskar Ragnarsson
PURPOSE: Patients with non-functioning pituitary adenomas (NFPA), especially women, have increased mortality. The aim of this study was to investigate whether mortality in NFPA patients has changed during the last two decades. METHODS: This was a nationwide population-based study including 2795 patients (1502 men, 1293 women) diagnosed with NFPA between 1997 and 2011. Patients were identified and followed in Swedish National Health Registries. Standardized mortality ratios (SMRs) with 95 % confidence intervals were calculated for three time periods at first NFPA diagnosis using the general population as reference...
October 14, 2016: Pituitary
Mitchell Brooks, Chris Ellis, Greg Gamble, Gerry Devlin, John Elliott, Chris Hammett, Derek Chew, John French, Tom Briffa, Julie Redfern, Jamie Rankin, Karice Hyun, Mario D'Souza, David Brieger
BACKGROUND: There is wide variation in the use of radial over femoral access for patients with ACS. This study evaluates the factors associated with the selection of radial versus femoral angiography in Australia and New Zealand and the effect of access site on clinical events in acute coronary syndrome (ACS) patients. METHODS: An analysis of the SNAPSHOT ACS audit was conducted during May 2012 across 286 hospitals in Australia and New Zealand. Data collected included baseline patient characteristics, hospital site details, treatment received, clinical events in-hospital and mortality at 18 months...
August 22, 2016: Heart, Lung & Circulation
Marco Soligo, Stefania Livio, Elena De Ponti, Ileana Scebba, Federica Carpentieri, Maurizio Serati, Enrico Ferrazzi
OBJECTIVE: Pelvic floor dysfunction after delivery is quite common. New mothers deserve to receive targeted care for pelvic floor dysfunction, but how should women who are at risk be identified and selected for treatment? This study investigated risk factors and puerperal health-seeking behaviours to develop a restrictive patient selection model for postpartum pelvic floor dysfunction assessment. STUDY DESIGN: This prospective observational study involved women who were at ≥32 weeks gestational age when they delivered in a tertiary referral maternity hospital in Milan, Italy, between July and December 2014...
September 21, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
B Barrou, N Chatauret, T Hauet, R Thuret, F Kleinclauss, M-O Timsit, R Codas, X Matillon, L Badet
AIMS: To describe ischemia-reperfusion mechanisms, the impact on kidney graft and strategies developed to minimize ischemia-reperfusion damages. MATERIAL AND METHODS: An exhaustive systematic review of the scientific literature was performed in the Medline database ( and Embase ( using different associations of the following keywords: ischemia-reperfusion; organ preservation; hypothermic machine perfusion; renal transplantation...
September 29, 2016: Progrès en Urologie
Tajia L Green, Stacey M Leventhal, Debora Lim, Kiho Cho, David G Greenhalgh
We previously identified a truncated human glucocorticoid receptor (hGR) isoform of 118 amino acids, hGR-S1(-349A), that despite lacking the major functional domains, was more hyperactive after glucocorticoid treatment than the full-length receptor. Furthermore, its 3' untranslated region (UTR) was required. To dissect the underlying mechanisms for hyperactivity, a series of hGR isoforms with consecutive deletions in the 3' UTR were created to test their transactivation potential using reporter assays. The hGR-S1(-349A) isoform retaining 1303 bp of 3' UTR displayed unusually high activity with or without glucocorticoid stimulation...
September 22, 2016: Shock
Matthew P M Graham-Brown, Daniel S March, Darren R Churchward, David J Stensel, Anvesha Singh, Ranjit Arnold, James O Burton, Gerry P McCann
Left ventricular hypertrophy and myocardial fibrosis frequently occur in patients with end-stage renal disease receiving hemodialysis therapy and are associated with poor prognosis. Native T1 mapping is a novel cardiac magnetic resonance imaging technique that measures native myocardial T1 relaxation, a surrogate of myocardial fibrosis. Here we compared global and segmental native myocardial T1 time and global longitudinal, circumferential and segmental strain, and cardiac function of 35 hemodialysis patients and 22 control individuals...
October 2016: Kidney International
E Cosset, T Petty, V Dutoit, D Tirefort, P Otten-Hernandez, L Farinelli, P-Y Dietrich, O Preynat-Seauve
Glioblastoma multiforme (GBM) is among the most aggressive cancers associated with massive infiltration of peritumoral parenchyma by migrating tumor cells. The infiltrative nature of GBM cells, the intratumoral heterogeneity concomitant with redundant signaling pathways likely underlie the inability of conventional and targeted therapies to achieve long-term remissions. In this respect, microRNAs (miRNAs), which are endogenous small non-coding RNAs that play a role in cancer aggressiveness, emerge as possible relevant prognostic biomarkers or therapeutic targets for treatment of malignant gliomas...
November 2016: Biomaterials
Rianne Huis 't Veld, Carmen van den Hoven, Erik Maartens, Stephanie Hoogendoorn, Roy Hoogeslag, Anil Peters, Christiaan Rompen, Jasper Reenalda
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
A Royden, A Wedley, J Y Merga, S Rushton, B Hald, T Humphrey, N J Williams
Campylobacter is the leading cause of bacterial diarrhoeal disease worldwide, with raw and undercooked poultry meat and products the primary source of infection. Colonization of broiler chicken flocks with Campylobacter has proved difficult to prevent, even with high levels of biosecurity. Dipteran flies are proven carriers of Campylobacter and their ingress into broiler houses may contribute to its transmission to broiler chickens. However, this has not been investigated in the UK. Campylobacter was cultured from 2195 flies collected from four UK broiler farms...
November 2016: Epidemiology and Infection
Isabela Porto De Toledo, Fabiane Miron Stefani, André Luís Porporatti, Luis André Mezzomo, Marco A Peres, Carlos Flores-Mir, Graziela De Luca Canto
OBJECTIVE: This study aims to estimate the prevalence of otologic signs and symptoms in adult patients with temporomandibular disorders (TMD). MATERIAL AND METHODS: Search strategies were developed for each of the following databases: PubMed, LILACS, Scopus, Web of Science, Proquest, LIVIVO, and Google Scholar and OpenGrey was used to assess the grey literature. It was included in this review only observational studies using either research diagnostic criteria (RDC)/TMD or DC/TMD indexes were selected...
August 10, 2016: Clinical Oral Investigations
András Schubert
Self-references, self-citations are considered by some as the sign of vanity, and deemed to be omitted from scientometrics analyses. In fact, self-citations reveal information in the study of scientific communications that is different but not less valuable than citations received from others. In the practice of self-citation severe ethical issues may emerge that can be bandled by the co-operation of the authors, editors and publishers. Orv. Hetil., 2016, 157(32), 1289-1293.
August 2016: Orvosi Hetilap
Nosaiba T Al-Ryalat, Saif Aldeen S AlRyalat, Lna W Malkawi, Ethar F Al-Zeena, Mahasen S Al Najar, Azmy M Hadidy
BACKGROUND AND PURPOSE: Noncontrasted computed tomography (NCCT) is used as the initial neuroimaging test of choice for patients who present with new-onset neurological symptoms. An apparently hyperattenuated venous sinus may lead to the suspicion of cerebral venous sinus thrombosis (CVST). Improved understanding of all factors that can affect attenuation of dural sinuses can guide triage of patients to or from further investigations of suspected CVST. The purpose of this retrospective study was to assess the effect of different factors including hematocrit (HCT), hemoglobin (Hb), age, BUN/Cr ratio (blood urea nitrogen-to-creatinine ratio), and gender on the attenuation of dural sinuses on brain NCCT...
October 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Jacob A Doll, Fengming Tang, Sharon Cresci, P Michael Ho, Thomas M Maddox, John A Spertus, Tracy Y Wang
BACKGROUND: Angina is common both before and after myocardial infarction (MI). Whether the change in angina status within the first 30 days after MI is associated with subsequent readmission and angina persistence is unknown. METHODS AND RESULTS: We studied 2915 MI patients enrolled at 24 hospitals in the Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH) registry. Angina before and 30 days after MI was assessed with the Seattle Angina Questionnaire...
June 2016: Journal of the American Heart Association
Sergio Bravo Baptista, Luís Raposo, Lino Santos, Ruben Ramos, Rita Calé, Elisabete Jorge, Carina Machado, Marco Costa, Eduardo Infante de Oliveira, João Costa, João Pipa, Nuno Fonseca, Jorge Guardado, Bruno Silva, Maria-João Sousa, João Carlos Silva, Alberto Rodrigues, Luís Seca, Renato Fernandes
BACKGROUND: Penetration of fractional flow reserve (FFR) in clinical practice varies extensively, and the applicability of results from randomized trials is understudied. We describe the extent to which the information gained from routine FFR affects patient management strategy and clinical outcome. METHODS AND RESULTS: Nonselected patients undergoing coronary angiography, in which at least 1 lesion was interrogated by FFR, were prospectively enrolled in a multicenter registry...
July 2016: Circulation. Cardiovascular Interventions
Jarred A Bressner, Gretchen L MacCarrick, Harry C Dietz, Paul D Sponseller
BACKGROUND: Loeys-Dietz syndrome (LDS) is a genetic connective tissue disorder. We sought to determine the incidence of scoliosis in patients with LDS, characterize the spectrum of spinal deformity, determine the results of bracing and surgery, and define surgical complications. METHODS: Patients were selected from our institution's database of 183 patients with LDS. Imaging measurements were performed for 141 patients whose records permitted spinal evaluation. Deformity changes and complications after intervention were recorded for patients who underwent bracing or surgery, and associations were tested using Student t tests (significance, P<0...
July 2, 2016: Journal of Pediatric Orthopedics
Polyana Campos Nunes, Jailane de Souza Aquino, Ismael Ivan Rockenbach, Tânia Lúcia Montenegro Stamford
The purpose of this study was to evaluate the physico-chemical characteristics, bioactive compounds and antioxidant activity of Malay apple fruit (Syzygium malaccense) grown in Brazil with regard to the geographical origin and its peel fractions and edible portion analyzed independently. Fruit diameter, weight, yield, and centesimal composition, ascorbic acid, reductive sugars, total soluble solids, pH and fiber content were determined. Total phenolics (1293 mg gallic acid equivalent/100 g) and total anthocyanins (1045 mg/100 g) contents were higher in the peel, with the major anthocyanin identified using HPLC-DAD-MS/MS as cyanidin 3-glucoside...
2016: PloS One
Stéphanie Guyomard-Rabenirina, Joyce Malespine, Célia Ducat, Syndia Sadikalay, Mélanie Falord, Dorothée Harrois, Vincent Richard, Charles Dozois, Sébastien Breurec, Antoine Talarmin
BACKGROUND: Urinary tract infections are bacterial infections most commonly encountered in the community. The resistance rate of uropathogens to commonly prescribed antibiotics has increased worldwide but there are no published data concerning the resistance of strains isolated from community-acquired UTI in Guadeloupe. To assess the susceptibility patterns of Enterobacteriaceae strains isolated from outpatients in Guadeloupe we conducted a prospective study from December 2012 to May 2014 among outpatients consulting at private and public laboratories for urine analysis...
2016: BMC Microbiology
Govind Babu Kanakasetty, Loknatha Dasappa, Kuntegowdanahalli Chinnagiriyappa Lakshmaiah, Mangesh Kamath, Linu Abraham Jacob, Suresh Babu Mallekavu, Lakkavalli Krishnappa Rajeev, Rudresha Antapura Haleshappa, Lokesh Kadabur Nagendrappa, Smitha Carol Saldanha, Rekha V Kumar
Purpose. Neuroendocrine neoplasms (NENs) of the esophagus are very uncommon with only a few studies published worldwide. Studies on clinical profile, management, and outcomes are very uncommon. Methods. We report the largest single institution retrospective review of 43 patients of pure esophageal NENs out of our registry of gastrointestinal neuroendocrine tumors treated between 2005 and 2014. Data on the incidence, tumor location, clinical symptoms, stage at presentation, grading, treatment protocol, and treatment outcomes was collected and analyzed...
2016: Journal of Oncology
Buyun Xu, Fang Peng, Weiliang Tang, Ye Du, Hangyuan Guo
BACKGROUND: The incidence of recurrent arrhythmia after catheter ablation (CA) for atrial fibrillation (AF) is unacceptable. Short-term antiarrhythmic drug (AAD) treatment following CA was presumed to be effective in reducing recurrent arrhythmia. OBJECTIVE: To fully evaluate the efficacy of short-term use of AADs following CA for AF in preventing recurrence of atrial tachyarrhythmias. METHODS: PubMed, Embase, Cochrane Library, and ClinicalTrials...
September 2016: Annals of Pharmacotherapy
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