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https://www.readbyqxmd.com/read/29452806/steroid-administration-after-anaesthetic-induction-with-etomidate-does-not-reduce-in-hospital-mortality-or-cardiovascular-morbidity-after-non-cardiac-surgery
#1
R Komatsu, J You, S Rajan, Y Kasuya, D I Sessler, A Turan
BACKGROUND: We tested the primary hypothesis that corticosteroid administration after etomidate exposure reduces a composite of in-hospital mortality and cardiovascular morbidity after non-cardiac surgery. METHODS: We evaluated ASA physical status III and IV patients who had non-cardiac surgery with general anaesthesia at the Cleveland Clinic. Amongst 4275 patients in whom anaesthesia was induced with etomidate, 804 were also given steroid intraoperatively, mostly dexamethasone at a median dose of 6 mg...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29451984/two-component-ferritin-nanoparticles-for-multimerization-of-diverse-trimeric-antigens
#2
Ivelin S Georgiev, Michael Gordon Joyce, Rita E Chen, Kwanyee Leung, Krisha McKee, Aliaksandr Druz, Joseph G Van Galen, Masaru Kanekiyo, Yaroslav Tsybovsky, Eun Sung Yang, Yongping Yang, Priyamvada Acharya, Marie Pancera, Paul V Thomas, Timothy Wanninger, Hadi Yassine, Ulrich Baxa, Nicole Doria-Rose, Cheng Cheng, Barney S Graham, John R Mascola, Peter D Kwong
Antigen multimerization on a nanoparticle can result in improved neutralizing antibody responses. A platform that has been successfully used for displaying antigens from a number of different viruses is ferritin, a self-assembling protein nanoparticle that allows the attachment of multiple copies (twenty-four monomers or eight trimers) of a single antigen. Here we design two-component ferritin variants that allow the attachment of two diverse antigens on a single particle in a defined ratio and geometric pattern...
February 16, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29451937/custom-triflange-acetabular-components-for-large-acetabular-defects-minimum-10-year-follow-up
#3
K David Moore, Michelle D McClenny, Bradley W Wills
Compromise of bony support presents a difficult problem in acetabular revision surgery. Although various methods have been proposed to cope with this problem, they have had variable results and little long-term follow-up. The authors reviewed the results of 37 patients undergoing custom triflange revision surgery. Two patients were lost to follow-up, leaving 35 patients with minimum 10-year clinical and radiographic follow-up. Thirty-two (91%) of 35 components were unrevised and functioning well at minimum 10-year follow-up...
February 16, 2018: Orthopedics
https://www.readbyqxmd.com/read/29451434/the-elr-sobir1-complex-functions-as-a-two-component-rlk-to-mount-defense-against-phytophthora-infestans
#4
Emmanouil Domazakis, Doret Wouters, Richard Visser, Sophien Kamoun, Matthieu Haj Joosten, Vivianne G A A Vleeshouwers
The ELICITIN RESPONSE (ELR) protein from Solanum microdontum can recognize INF1 elicitin of Phytophthora infestans and trigger defense responses. ELR is a receptor-like protein (RLP) that lacks a cytoplasmic signaling domain and is anticipated to require interaction with a signaling-competent receptor-like kinase (RLK). SUPPRESSOR OF BIR1-1 (SOBIR1) has been proposed as a general interactor for RLPs involved in immunity and as such, is a potential interactor for ELR. Here we investigate whether SOBIR1 is required for response to INF1 and resistance to P...
February 16, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29451384/a-highly-elastic-biodegradable-single-network-hydrogel-for-cell-printing
#5
Cancan Xu, Wenhan Lee, Guohao Dai, Yi Hong
Cell printing is becoming a common technique to fabricate cellularized printed-scaffold for biomedical application. There are still significant challenges in soft tissue bioprinting using hydrogels which requires live cells inside the hydrogels. Moreover, the resilient mechanical properties from hydrogels are also required to mechanically mimic the native soft tissues. Herein, we developed a visible-light crosslinked, single-network, biodegradable hydrogel with high elasticity and flexibility for cell printing, which is different from previous highly elastic hydrogel with double-network and two-components...
February 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29448797/laser-desorption-vs-electrospray-of-polyyne-threaded-rotaxanes-preventing-covalent-cross-linking-and-promoting-noncovalent-aggregation
#6
Thomas S Neugebauer, Michael Franz, Stephanie Frankenberger, Rik R Tykwinski, Thomas Drewello
Laser-induced cross-linking of polyynes is successfully hindered when the polyyne is encapsulated as part of a rotaxane and therefore protected by a surrounding macrocycle. When the rotaxane is electrosprayed, however, noncovalent aggregate ions are efficiently formed. Aggregates of considerable size (including more than 50 rotaxane molecules with masses beyond 100k Da) and charge states (up to 13 charges and beyond) have been observed. Either protons or sodium cations act as the charge carriers. These aggregates are not formed when the individual components of the rotaxane, i...
February 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29448529/improved-adsorption-performance-of-%C3%AE-fe%C3%A2-o%C3%A2-modified-with-carbon-spheres-for-cr-vi-removal-from-aqueous-solution
#7
Hongtao Gao, Miaomiao Kong, Hui Song, Tian Fu, Dongmei Dai, Fenghua Li, Chongdian Si
Carbons spheres, easily fabricated by glucose hydrolysis, were integrated with α-Fe2O3 for removing heavy metal from contaminated water. The α-Fe2O3 particles were anchored on the surface of carbon spheres and the combination of two components provided more rough surface area, enhancing the adsorption performance of α-Fe2O3. The removal efficiency of Cr(VI) on α-Fe2O3/carbon spheres was 88% in 240 min, which was 1.93 times higher than that of pristine α-Fe2O3. The investigation on adsorption kinetics and isotherm showed that the pseudo-first-order kinetic and Langmuir isotherm models could well fit the experimental data...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448526/physico-chemical-electrochemical-and-structural-insights-into-poly-3-4-ethylenedioxythiophene-grafted-from-molecularly-engineered-multi-walled-carbon-nanotube-surfaces
#8
Teresa Gatti, Giorgia Girardi, Nicola Vicentini, Riccardo Brandiele, Maarten Wirix, Christian Durante, Enzo Menna
Composites of multi-walled carbon nanotubes (MWCNTs) and poly(3,4-ethylenedioxythiophene) (PEDOT) are attracting the attention of material scientists since more than a decade as potential next-generation optoelectronic materials for their peculiar features, arising from the combination of the intrinsic electrical, thermal and morphological properties of the two components. They are indeed a promising platform for the development of low-cost, portable and environmentally friendly electronic devices such as supercapacitors, sensors and actuators...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448372/quantum-theory-for-the-dynamic-structure-factor-in-correlated-two-component-systems-in-nonequilibrium-application-to-x-ray-scattering
#9
J Vorberger, D A Chapman
We present a quantum theory for the dynamic structure factors in nonequilibrium, correlated, two-component systems such as plasmas or warm dense matter. The polarization function, which is needed as the input for the calculation of the structure factors, is calculated in nonequilibrium based on a perturbation expansion in the interaction strength. To make our theory applicable for x-ray scattering, a generalized Chihara decomposition for the total electron structure factor in nonequilibrium is derived. Examples are given and the influence of correlations and exchange on the structure and the x-ray-scattering spectrum are discussed for a model nonequilibrium distribution, as often encountered during laser heating of materials, as well as for two-temperature systems...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29444664/the-knitting-community-based-trial-for-older-women-with-osteoarthritis-of-the-hands-design-and-rationale-of-a-randomized-controlled-trial
#10
Paulette Guitard, Lucie Brosseau, George A Wells, Nicole Paquet, Gail Paterson, Karine Toupin-April, Sabrina Cavallo, Sibel Z Aydin, Guillaume Léonard, Gino De Angelis
BACKGROUND: The prevalence of hand osteoarthritis (HOA) has been reported to be higher amongst women over 50 years old (66%) compared to men of the same age (34%). Although exercise therapy has been shown effective in reducing symptoms and disability associated with HOA, adherence to treatment programs remains low. The primary objective of this RCT is to examine the effectiveness of a 12-week knitting program for morning stiffness (primary outcome) and pain relief (secondary outcome) 2 h post-wakening in females (aged 50 to 85 years old) with mild to moderate hand osteoarthritis (HOA)...
February 14, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29444418/circuitry-rewiring-directly-couples-competence-to-predation-in-the-gut-dweller-streptococcus-salivarius
#11
Johann Mignolet, Laetitia Fontaine, Andrea Sass, Catherine Nannan, Jacques Mahillon, Tom Coenye, Pascal Hols
Small distortions in transcriptional networks might lead to drastic phenotypical changes, especially in cellular developmental programs such as competence for natural transformation. Here, we report a pervasive circuitry rewiring for competence and predation interplay in commensal streptococci. Canonically, in streptococci paradigms such as Streptococcus pneumoniae and Streptococcus mutans, the pheromone-based two-component system BlpRH is a central node that orchestrates the production of antimicrobial compounds (bacteriocins) and incorporates signal from the competence activation cascade...
February 13, 2018: Cell Reports
https://www.readbyqxmd.com/read/29438671/the-structure-of-the-biofilm-controlling-response-regulator-bfmr-from-acinetobacter-baumannii-reveals-details-of-its-dna-binding-mechanism
#12
G Logan Draughn, Morgan E Milton, Erik A Feldmann, Benjamin G Bobay, Braden M Roth, Andrew L Olson, Richele J Thompson, Luis A Actis, Christopher Davies, John Cavanagh
The rise of drug-resistant bacterial infections coupled with decreasing antibiotic efficacy poses a significant challenge to global healthcare. Acinetobacter baumannii is an insidious, emerging bacterial pathogen responsible for severe nosocomial infections aided by its ability to form biofilms. The response regulator BfmR, from the BfmR/S two-component system, is the master regulator of biofilm initiation in A. baumannii and is a tractable therapeutic target. Here we present the structure of A. baumannii BfmR using a hybrid approach combining X-ray crystallography, nuclear magnetic resonance spectroscopy, chemical crosslinking mass spectrometry, and molecular modeling...
February 10, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29438424/vestibular-schwannomas-accuracy-of-tumor-volume-estimated-by-ice-cream-cone-formula-using-thin-sliced-mr-images
#13
Hsing-Hao Ho, Ya-Hui Li, Jih-Chin Lee, Chih-Wei Wang, Yi-Lin Yu, Dueng-Yuan Hueng, Hsin-I Ma, Hsian-He Hsu, Chun-Jung Juan
PURPOSE: We estimated the volume of vestibular schwannomas by an ice cream cone formula using thin-sliced magnetic resonance images (MRI) and compared the estimation accuracy among different estimating formulas and between different models. METHODS: The study was approved by a local institutional review board. A total of 100 patients with vestibular schwannomas examined by MRI between January 2011 and November 2015 were enrolled retrospectively. Informed consent was waived...
2018: PloS One
https://www.readbyqxmd.com/read/29437455/realizing-fulde-ferrell-superfluids-via-a-dark-state-control-of-feshbach-resonances
#14
Lianyi He, Hui Hu, Xia-Ji Liu
We propose that the long-sought Fulde-Ferrell superfluidity with nonzero momentum pairing can be realized in ultracold two-component Fermi gases of ^{40}K or ^{6}Li atoms by optically tuning their magnetic Feshbach resonances via the creation of a closed-channel dark state with a Doppler-shifted Stark effect. In this scheme, two counterpropagating optical fields are applied to couple two molecular states in the closed channel to an excited molecular state, leading to a significant violation of Galilean invariance in the dark-state regime and hence to the possibility of Fulde-Ferrell superfluidity...
January 26, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29436284/compassion-fatigue-and-compassion-satisfaction-among-family-physicians-in-the-republic-of-srpska-bosnia-and-herzegovina
#15
Maja Račić, Aleksandra Virijević, Nedeljka Ivković, Bojan N Joksimović, Vedrana R Joksimović, Biljana Mijovic
AIMS: The aim of this study was to examine self-perceived compassion fatigue and compassion satisfaction among family physicians in Bosnia and Herzegovina and to describe potential contributing factors. MATERIAL AND METHODS: The cross-sectional study enrolled 120 family physicians. Professional Quality of Life Compassion Satisfaction and Fatigue, Version 5 (ProQOL5) was used to assess compassion satisfaction, and two components of compassion fatigue, secondary traumatic stress and burnout...
February 13, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29435957/oscillations-of-subarachnoid-space-width-as-a-potential-marker-of-cerebrospinal-fluid-pulsatility
#16
Marcin Gruszecki, Magdalena K Nuckowska, Arkadiusz Szarmach, Marek Radkowski, Dominika Szalewska, Monika Waskow, Edyta Szurowska, Andrzej F Frydrychowski, Urszula Demkow, Pawel J Winklewski
In the cerebrospinal fluid (CSF) circulation, two components can be distinguished: bulk flow (circulation) and pulsatile flow (back and forth motion). CSF pulsatile flow is generated by both cardiac and respiratory cycles. Recent years have seen increased interest in cardiac and respiratory-driven CSF pulsatility as an important component of cerebral homeostasis. CSF pulsatility is affected by cerebral arterial inflow and jugular outflow and potentially linked to white matter abnormalities in various diseases, such as multiple sclerosis or hypertension...
February 13, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29434938/genetic-characterization-and-in-vitro-activity-of-antimicrobial-combinations-of-multidrug-resistant-acinetobacter-baumannii-from-a-general-hospital-in-china
#17
Fang Chen, Ling Wang, Min Wang, Yixin Xie, Xiaomeng Xia, Xianping Li, Yanhua Liu, Wei Cao, Tingting Zhang, Pengling Li, Min Yang
The present study aimed to develop a rational therapy based on the genetic epidemiology, molecular mechanism evaluation and in vitro antibiotic combinations activity in multidrug-resistant Acinetobacter baumannii (MDRAB). MDRAB was screened by the Kirby-Bauer method. The random amplified polymorphic DNA technique was used to establish genetic fingerprinting, and a series of resistance genes were detected by polymerase chain reaction. Antimicrobial agents including amikacin (AK), cefoperazone/sulbactam (SCF I/II), meropenem (MEM), minocycline (MINO) and ciprofloxacin (CIP) were used to determine the minimum inhibitory concentrations (MICs) and interactions between antibiotics by the broth microdilution method and chequerboard assays...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29431883/an-optical-sensor-array-discriminates-syrups-and-honeys
#18
Uwe Heiko Bunz, N Maximilian Bojanowski, Felix Hainer, Markus Bender, Kai Seehafer
We report a cross-reactive sensor array, combining a two-component probe system based upon three viologen substituted boronic acids and a poly(aryleneethynylene) (PAE) and an additional number of simple PAEs alone. This combined system discriminates 27 different honeys in aqueous solution, according to patterns in fluorescence intensity modulation, using linear discriminant and principal component analysis for data processing. The fluorescence turn-on array detects saccharide composition, while the PAEs discriminate trace colored components in the honeys...
February 12, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29429088/monitoring-two-component-sensor-kinases-with-a-chemotaxis-signal-readout
#19
Run-Zhi Lai, John S Parkinson
Bacteria use two-component signal transduction systems to elicit adaptive responses to environmental changes. The simplest of these systems comprises a transmembrane sensor with histidine kinase activity and its cytoplasmic response regulator partner. Stimulus-response studies of two-component signaling systems typically employ expression reporters, such as β-galactosidase, that operate with relatively slow kinetics and low precision. In this chapter, we illustrate a new strategy for directly measuring the signaling activities of two-component sensor kinases in vivo...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29427424/resde-two-component-regulatory-system-mediates-oxygen-limitation-induced-biofilm-formation-in-bacillus-amyloliquefaciens-sqr9
#20
Xuan Zhou, Nan Zhang, Liming Xia, Qing Li, Jiahui Shao, Qirong Shen, Ruifu Zhang
Efficient biofilm formation and root colonization capabilities facilitate the ability of beneficial plant rhizobacteria to promote plant growth and antagonize soil-borne pathogens. Biofilm formation by plant-beneficial Bacillus strains is triggered by environmental cues, including oxygen deficiency, but the pathways that sense these environmental signals and regulate biofilm formation have not been thoroughly elucidated. In this study, we showed that the ResDE two-component regulatory system in the plant growth-promoting rhizobacterium Bacillus amyloliquefaciens SQR9 senses the oxygen deficiency signal and regulates biofilm formation...
February 2, 2018: Applied and Environmental Microbiology
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