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https://www.readbyqxmd.com/read/28820408/-thrombophilic-genetic-mutations-and-polymorphisms-in-women-with-infertility-and-failed-in-vitro-fertilization
#1
G Abrahamyan
Occurrence of pregnancy after in vitro fertilization depends of two components: functional adequacy of the embryo at the blastocyst stage and receptivity of endometrium, which, according to modern perception, are determinate in achieving optimal conditions of implantation. From the pregnancy occurrence point of view, as well as in regard to its further development , implantation is the most crucial phase of IVF/ICSI and ET. As the same time, this phase is also the most vulnerable. Multiple researches have proven the role of mother thrombophilia for genesis of gestation complications and early embryo losses, but in relation to this problem i the context of IVF there is still a lot to be detailed...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28818740/assessment-of-genotoxicity-of-four-volatile-pollutants-from-cigarette-smoke-based-on-the-in-vitro-%C3%AE-h2ax-assay-using-high-content-screening
#2
Sen Zhang, Huan Chen, An Wang, Yong Liu, Hongwei Hou, Qingyuan Hu
To evaluate the genotoxic effects of formaldehyde, acetaldehyde, acrolein and benzene on A549 cells, the in vitro γH2AX assay was used in combination with high content screening (HCS) technology. All aldehydes showed a significant genotoxicity in a dose/time-dependent effect on the induction of γH2AX. Benzene failed to show a significant genotoxicity based on the γH2AX assay. However, hydroquinone (one of metabolites of benzene) showed a significant genotoxicity in vitro. Based on the dose-response of γH2AX and Hill model, the ability to induce DNA double-strand break can be evaluated as acrolein>formaldehyde>acetaldehyde>benzene...
July 18, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28818558/current-and-emerging-pharmacotherapies-for-obesity-in-australia
#3
REVIEW
Samantha Hocking, Anthony Dear, Michael A Cowley
BACKGROUND: Obesity is a major issue in Australia and globally. Many individuals struggle to maintain weight loss with lifestyle modification, and adjunctive pharmacotherapy may help. Historically, there have been limited pharmacotherapies for managing obesity. In addition, previous treatments such as phentermine-fenfluramine, rimonabant and sibutramine were withdrawn due to safety issues, resulting in lingering safety concerns. METHODS: This is a narrative review of published data examining four new pharmacotherapy options for weight management in Australia...
August 14, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28817193/response-reinforcer-dependency-and-resistance-to-change
#4
Carlos R X Cançado, Josele Abreu-Rodrigues, Raquel Moreira Aló, Flávia Hauck, Adam H Doughty
The effects of the response-reinforcer dependency on resistance to change were studied in three experiments with rats. In Experiment 1, lever pressing produced reinforcers at similar rates after variable interreinforcer intervals in each component of a two-component multiple schedule. Across conditions, in the fixed component, all reinforcers were response-dependent; in the alternative component, the percentage of response-dependent reinforcers was 100, 50 (i.e., 50% response-dependent and 50% response-independent) or 10% (i...
August 17, 2017: Journal of the Experimental Analysis of Behavior
https://www.readbyqxmd.com/read/28814735/self-assembly-of-ternary-hollow-microspheres-with-strong-wideband-microwave-absorption-and-controllable-microwave-absorption-properties
#5
Qiang Zeng, Ping Chen, Qi Yu, Hai-Rong Chu, Xu-Hai Xiong, Dong-Wei Xu, Qi Wang
In this study, we report a simple and efficient two-step method consisting of water-in-oil (W/O) emulsion technique and subsequent annealing process for synthesizing the hollow reduced graphene oxide microspheres embedded with Co nanoparticles (Air@rGO€Co). The microspheres showed good electromagnetic properties because of the coexistence of magnetic loss and dielectric loss to microwaves. The minimum reflection loss (RLmin) value of S1.5 reaches -68.1 dB at 13.8 GHz with a thickness of 2.2 mm, and the absorption bandwidth (lower than -10 dB) is 7...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28813566/a-nonlinear-generalization-of-the-savitzky-golay-filter-and-the-quantitative-analysis-of-saccades
#6
Weiwei Dai, Ivan Selesnick, John-Ross Rizzo, Janet Rucker, Todd Hudson
The Savitzky-Golay (SG) filter is widely used to smooth and differentiate time series, especially biomedical data. However, time series that exhibit abrupt departures from their typical trends, such as sharp waves or steps, which are of physiological interest, tend to be oversmoothed by the SG filter. Hence, the SG filter tends to systematically underestimate physiological parameters in certain situations. This article proposes a generalization of the SG filter to more accurately track abrupt deviations in time series, leading to more accurate parameter estimates (e...
August 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28809866/-employee-wellbeing-in-a-university-department-italy
#7
Alessandra Sinopoli, Cristina Sestili, Bruno Lojodice, Sabina Sernia, Alice Mannocci, Maria De Giusti, Paolo Villari, Giuseppe La Torre
A serene workplace environment can provide significant benefits to employees. The aim of the present study was to assess wellbeing of employees in a university department, by administering validated questionnaires (Karasek and INAIL) and to determine any similarities and / or differences. The sample consisted of 48 employees (22.9 % male and 77.1% female) in various job categories including doctors, biologists, nurses, and technical and administrative staff. Results obtained from the Karasek questionnaire allowed us to calculate the values of Decision latidude and Job demand...
May 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/28809495/a-copper-i-catalyzed-addition-annulation-sequence-for-the-two-component-synthesis-of-%C3%AE-ylidenebutenolides
#8
Sangwon Seo, Michael C Willis
A highly efficient Cu(I)-catalyzed addition/annulation sequence has been developed for the synthesis of (Z)-ylidenebutenolides employing readily available α-ketoacids and alkynes as substrates. The reactions employ a simple commercially available Cu(I)-catalyst, display good substrate scope, and deliver products with high stereoselectivity. The synthetic utility of the method is demonstrated by the straightforward derivatization of the ylidenebutenolides into a diverse range of heterocycles, and also by the preparation of the natural product bovolide, and analogs thereof...
August 15, 2017: Organic Letters
https://www.readbyqxmd.com/read/28809156/the-length-of-poly-c-stretch-in-the-bordetella-pertussis-pfim3-promoter-determines-the-vag-or-vrg-function-of-the-fim3-gene
#9
Nao Otsuka, Nicole Guiso, Valérie Bouchez
Bordetella pertussis, a human pathogenic bacterium, produces either one or two types of serologically distinct fimbriae, Fim2 and Fim3, as virulence factors. The expression of fim2 and fim3 is regulated by the BvgAS two-component system and the length of poly(C) stretches in Pfim promoters. In the Bvg+ phase, B. pertussis virulence-activated genes (vags) are up-regulated and virulence-repressed genes (vrgs) are down-regulated. Previous studies have shown that fim2 is a vag, but there is no consensus on fim3 regulation...
August 15, 2017: Microbiology
https://www.readbyqxmd.com/read/28808155/roca-is-an-accessory-protein-to-the-virulence-regulating-covr-s-two-component-system-in-the-group-a-streptococcus
#10
Ira Jain, Eric W Miller, Jessica L Danger, Kathryn J Pflughoeft, Paul Sumby
Regulating gene expression during infection is critical to the ability of pathogens to circumvent the immune response and cause disease. This is true for the group A Streptococcus (GAS), a pathogen that causes both invasive (e.g. necrotizing fasciitis) and non-invasive (e.g. pharyngitis) diseases. The control of virulence (CovR/S) two-component system has a major role in regulating GAS virulence factor expression. The regulator of cov (RocA) protein, which is a predicted kinase, functions in an undetermined manner through CovR/S to alter gene expression and reduce invasive disease virulence...
August 14, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28805688/7-dialkylaminocoumarin-oximates-small-molecule-fluorescent-turn-on-chemosensors-for-low-level-water-content-in-aprotic-organic-solvents
#11
Marek Cigáň, Miroslav Horváth, Juraj Filo, Klaudia Jakusová, Jana Donovalová, Vladimír Garaj, Anton Gáplovský
The water sensing properties of two efficient two-component fluorescent "turn-on" chemo-sensors based on the 7-dialkylaminocoumarin oxime acid-base equilibrium were investigated. Interestingly, although simple frontier orbital analysis predicts an intramolecular photoinduced electron transfer quenching pathway in conjugated oximates, TD-DFT (Time-dependent density functional theory) quantum chemical calculations support non-radiative dark S₁ excited state deactivation as a fluorescence quenching mechanism...
August 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28805355/sensing-mg-2-contributes-to-the-resistance-of-pseudomonas-aeruginosa-to-complement-mediated-opsonophagocytosis
#12
Mohammad Qadi, Sofía Izquierdo-Rabassa, Margalida Mateu Borrás, Antonio Doménech-Sánchez, Carlos Juan, Joanna B Goldberg, Robert E W Hancock, Sebastián Albertí
Pseudomonas aeruginosa adaptation to survive in the host hinges on its ability to probe the environment and respond appropriately. Rapid adaptation is often mediated by two-component regulatory systems, such as the PhoP/PhoQ system that responds to Mg(2+) ion concentration. However, there is limited information about the role of PhoQ in P. aeruginosa bloodstream infections. We used a murine model of systemic infection to test the virulence of a PhoQ-deficient mutant. Mutation of PhoQ impaired the virulence and the ability to cause bacteremia of P...
August 14, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28802690/nanoparticle-releasing-nanofiber-composites-for-enhanced-in%C3%A2-vivo-vaginal-retention
#13
Emily A Krogstad, Renuka Ramanathan, Christina Nhan, John C Kraft, Anna K Blakney, Shijie Cao, Rodney J Y Ho, Kim A Woodrow
Current approaches for topical vaginal administration of nanoparticles result in poor retention and extensive leakage. To overcome these challenges, we developed a nanoparticle-releasing nanofiber delivery platform and evaluated its ability to improve nanoparticle retention in a murine model. We individually tailored two components of this drug delivery system for optimal interaction with mucus, designing (1) mucoadhesive fibers for better retention in the vaginal tract, and (2) PEGylated nanoparticles that diffuse quickly through mucus...
August 1, 2017: Biomaterials
https://www.readbyqxmd.com/read/28802267/development-of-a-transient-muts-based-hypermutation-system-for-adaptive-evolution-of-lactobacillus-casei-to-low-ph
#14
Tom J Overbeck, Dennis L Welker, Joanne E Hughes, James L Steele, Jeff R Broadbent
This study explored transient inactivation of the gene encoding the DNA mismatch repair enzyme MutS as a tool for adaptive evolution of Lactobacillus casei MutS deletion derivatives of L. casei 12A and ATCC 334 were constructed and subject to a 100-day adaptive evolution process to increase lactic acid resistance at low pH. Wild-type parental strains were also subject to this treatment. At the end of the process, the ΔmutS lesion was repaired in representative L. casei 12A and ATCC 334 ΔmutS isolates. Growth studies in broth at pH 4...
August 11, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28800172/viscous-drag-on-the-flagellum-activates-bacillus-subtilis-entry-into-the-k-state
#15
Christine Diethmaier, Ravi Chawla, Alexandra Canzoneri, Daniel B Kearns, Pushkar P Lele, David Dubnau
Bacillus subtilis flagella are not only required for locomotion but also act as sensors that monitor environmental changes. Although how the signal transmission takes place is poorly understood, it has been shown that flagella play an important role in surface sensing by transmitting a mechanical signal to control the DegS-DegU two-component system. Here we report a role for flagella in the regulation of the K-state, which enables transformability and antibiotic tolerance (persistence). Mutations impairing flagellar synthesis are inferred to increase DegU-P, which inhibits the expression of ComK, the master regulator for the K-state, and reduces transformability...
August 11, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28798726/systems-biology-analysis-of-temporal-in-vivo-brucella-melitensis-and-bovine-transcriptomes-predicts-host-pathogen-protein-protein-interactions
#16
Carlos A Rossetti, Kenneth L Drake, Sara D Lawhon, Jairo S Nunes, Tamara Gull, Sangeeta Khare, Leslie G Adams
To date, fewer than 200 gene-products have been identified as Brucella virulence factors, and most were characterized individually without considering how they are temporally and coordinately expressed or secreted during the infection process. Here, we describe and analyze the in vivo temporal transcriptional profile of Brucella melitensis during the initial 4 h interaction with cattle. Pathway analysis revealed an activation of the "Two component system" providing evidence that the in vivo Brucella sense and actively regulate their metabolism through the transition to an intracellular lifestyle...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28798374/culture-independent-assessment-of-human-milk-microbial-community-in-lactational-mastitis
#17
Shriram H Patel, Yati H Vaidya, Reena J Patel, Ramesh J Pandit, Chaitanya G Joshi, Anju P Kunjadiya
Breastfeeding undoubtedly provides important benefits to the mother-infant dyad and should be encouraged. Mastitis, one of the common but major cause of premature weaning among lactating women, is an inflammation of connective tissue within the mammary gland. This study reports the influence of mastitis on human milk microbiota by utilizing 16 S rRNA gene sequencing approach. We sampled and sequenced microbiome from 50 human milk samples, including 16 subacute mastitis (SAM), 16 acute mastitis (AM) and 18 healthy-controls...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797307/using-smartphones-to-decrease-substance-use-via-self-monitoring-and-recovery-support-study-protocol-for-a-randomized-control-trial
#18
Christy K Scott, Michael L Dennis, David H Gustafson
BACKGROUND: Alcohol abuse, other substance use disorders, and risk behaviors associated with the human immunodeficiency virus (HIV) represent three of the top 10 modifiable causes of mortality in the US. Despite evidence that continuing care is effective in sustaining recovery from substance use disorders and associated behaviors, patients rarely receive it. Smartphone applications (apps) have been effective in delivering continuing care to patients almost anywhere and anytime. This study tests the effectiveness of two components of such apps: ongoing self-monitoring through Ecological Momentary Assessments (EMAs) and immediate recovery support through Ecological Momentary Interventions (EMIs)...
August 10, 2017: Trials
https://www.readbyqxmd.com/read/28796832/comparative-analysis-of-lyts-lyttr-type-histidine-kinase-response-regulator-systems-in-%C3%AE-proteobacteria
#19
Stefan Behr, Sophie Brameyer, Michael Witting, Philipp Schmitt-Kopplin, Kirsten Jung
Bacterial histidine kinase/response regulator systems operate at the interface between environmental cues and physiological states. Escherichia coli contains two LytS/LytTR-type histidine kinase/response regulator systems, BtsS/BtsR (formerly YehU/YehT) and YpdA/YpdB, which have been identified as pyruvate-responsive two-component systems. Since they exhibit remarkable similarity, we analyzed their phylogenetic distribution within the γ-proteobacteria, and experimentally characterized them in a set of representative species...
2017: PloS One
https://www.readbyqxmd.com/read/28792745/sequential-combination-of-electro-fenton-and-electrochemical-chlorination-processes-for-treatment-of-anaerobically-digested-food-wastewater
#20
Yong-Uk Shin, Ha-Young Yoo, Seonghun Kim, Kyung-Mi Chung, Yong-Gyun Park, Kwang-Hyun Hwang, Seokwon Hong, Hyunwoong Park, Kangwoo Cho, Jaesang Lee
A two-stage sequential electro-Fenton (E-Fenton) oxidation followed by electrochemical chlorination (EC) was demonstrated to concomitantly treat high concentrations of organic carbon and ammonium nitrogen (NH4+-N) in real anaerobically-digested food wastewater (ADFW). The anodic Fenton process caused the rapid mineralization of phenol as a model substrate through the production of hydroxyl radical as the main oxidant. The electrochemical oxidation of NH4+ by a dimensionally stable anode (DSA) resulted in temporal concentration profiles of combined and free chlorine species that were analogous to those during the conventional breakpoint chlorination of NH4+...
August 9, 2017: Environmental Science & Technology
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