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https://www.readbyqxmd.com/read/29460025/combined-model-based-and-patient-specific-dosimetry-for-18-f-dcfpyl-a-psma-targeted-pet-agent
#1
Donika Plyku, Esther Mena, Steven P Rowe, Martin A Lodge, Zsolt Szabo, Steve Y Cho, Martin G Pomper, George Sgouros, Robert F Hobbs
PURPOSE: Prostate-specific membrane antigen (PSMA), a type-II integral membrane protein highly expressed in prostate cancer, has been extensively used as a target for imaging and therapy. Among the available PET radiotracers, the low molecular weight agents that bind to PSMA are proving particularly effective. We present the dosimetry results for18 F-DCFPyL in nine patients with metastatic prostate cancer. METHODS: Nine patients were imaged using sequential PET/CT scans at approximately 1, 12, 35 and 70 min, and a final PET/CT scan at approximately 120 min after intravenous administration of 321 ± 8 MBq (8...
February 19, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29452869/three-dimensional-printer-aided-casting-of-soft-custom-silicone-boluses-scsbs-for-head-and-neck-radiation-therapy
#2
Tsuicheng Chiu, Jun Tan, Mathew Brenner, Xuejun Gu, Ming Yang, Kenneth Westover, Tobin Strom, David Sher, Steve Jiang, Bo Zhao
PURPOSE: Custom tissue compensators provide dosimetric advantages for treating superficial or complex anatomy, but currently available fabrication technology is expensive or impractical for most clinical operations and yields compensators that are difficult for patients to tolerate. We aimed to develop an inexpensive, clinically feasible workflow for generating patient-specific, soft, custom silicone boluses (SCSBs) for head-and-neck (HN) radiation therapy. METHODS AND MATERIALS: We developed a method using 3-dimensional printed parts for generating SCSBs for the treatment of HN cancers...
November 11, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29443366/paradoxical-anatomic-response-to-topical-carbonic-anhydrase-inhibitor-in-x-linked-retinoschisis
#3
Brandon Menke, Alex Walters, John F Payne
An 11-year-old boy presented for central vision blurring in each eye. Visual acuity was 20/80 and examination revealed spoke-wheel foveal schisis and peripheral elevated diaphanous inner retina in each eye. Spectral-domain optical coherence tomography showed inner-retinal, flat-topped cysts in each eye. Electrophysiologic testing was refused, but a clinical diagnosis of X-linked retinoschisis was made. Three months after topical dorzolamide (Trusopt; Santen Pharmaceutical, Osaka, Japan) was started, the macular cysts worsened significantly...
February 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29439089/yellow-577-nm-micropulse-laser-versus-half-dose-verteporfin-photodynamic-therapy-in-eyes-with-chronic-central-serous-chorioretinopathy-results-of-the-pan-american-collaborative-retina-study-pacores-group
#4
Jose A Roca, Lihteh Wu, Jans Fromow-Guerra, Francisco J Rodríguez, Maria H Berrocal, Sergio Rojas, Luiz H Lima, Roberto Gallego-Pinazo, Jay Chhablani, J Fernando Arevalo, David Lozano-Rechy, Martin Serrano
PURPOSE: To compare the functional and anatomical outcomes of eyes with chronic central serous chorioretinopathy treated with yellow micropulse (MP) laser versus half-dose verteporfin photodynamic therapy (PDT). METHODS: This is a multicentre, retrospective comparative study of 92 eyes treated with yellow MP laser (duty cycle of 5%, zero spacing between spots, spot size varied from 100 to 200 µm, power varied from 320 to 660 mW, and the pulse burst duration was 200 ms) and 67 eyes treated with PDT (half-dose verteporfin (3 mg/m 2 ) infused over 10 min), followed by laser activation for 83 s...
February 8, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29430481/robotic-drill-guide-positioning-using-known-component-3d-2d-image-registration
#5
Thomas Yi, Vignesh Ramchandran, Jeffrey H Siewerdsen, Ali Uneri
A method for x-ray image-guided robotic instrument positioning is reported and evaluated in preclinical studies of spinal pedicle screw placement with the aim of improving delivery of transpedicle K-wires and screws. The known-component (KC) registration algorithm was used to register the three-dimensional patient CT and drill guide surface model to intraoperative two-dimensional radiographs. Resulting transformations, combined with offline hand-eye calibration, drive the robotically held drill guide to target trajectories defined in the preoperative CT...
April 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29422857/application-of-arterial-spin-labelling-in-detecting-retinal-ischemia
#6
Ehsan Vaghefi, Kevin Kauv, Wilson Pan, David Squirrell
Purpose: Here, we have tried to quantify the chorioretinal blood perfusion in patients who are clinically identified to be suffering from retinal ischemia using arterial spin labelling (ASL) MRI. Method: Four participants, diagnosed with retinal ischemia based on their structural OCT and angiography test, were then scanned using anatomical MRI as well as ASL. We optimized MR parameters to maximize resolution and target fixation, blinking, and breathing ques to minimize motion artifacts...
September 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29416828/asymmetrically-enlarged-parietal-foramina-in-a-rare-case-of-goldenhar-syndrome-with-a-possible-etiopathogenesis
#7
Lika'a Fasih Y Al-Kzayer, Shamil Naji Sarsam, Nagham Younus Alhur, Tingting Liu, Yozo Nakazawa
Goldenhar´s syndrome (GS) also known as oculo-auriculo-vertebral spectrum (OAVS) is a relatively rare condition. GS is of multifactorial etiology that includes environmental and/or genetic factors, in addition to teratogens that disturb the blastogenesis. A 5-year-old girl from Saudi Arabia, was a member of dizygotic twins conceived by assisted reproductive technology (ART), and born with features of GS. She had asymmetrical face, cleft lip and palate, right microphthalmia and microtia. Radiological imaging showed right maxillary and mandibular bone hypoplasia, asymmetrically enlarged parietal foramina, a persistent midline occipital foramen, abnormal bone arising from occipital bone, extending along tentorium cerebelli, and a lipoma at the right tentorium cerebelli...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415286/gaze-patterns-hold-key-to-unlocking-successful-search-strategies-and-increasing-polyp-detection-rate-in-colonoscopy
#8
Mariam Lami, Harsimrat Singh, James H Dilley, Hajra Ashraf, Matthew Edmondon, Felipe Orihuela-Espina, Jonathan Hoare, Ara Darzi, Mikael H Sodergren
BACKGROUND:  The adenoma detection rate (ADR) is an important quality indicator in colonoscopy. The aim of this study was to evaluate the changes in visual gaze patterns (VGPs) with increasing polyp detection rate (PDR), a surrogate marker of ADR. METHODS:  18 endoscopists participated in the study. VGPs were measured using eye-tracking technology during the withdrawal phase of colonoscopy. VGPs were characterized using two analyses - screen and anatomy. Eye-tracking parameters were used to characterize performance, which was further substantiated using hidden Markov model (HMM) analysis...
February 7, 2018: Endoscopy
https://www.readbyqxmd.com/read/29407941/active-inference-and-the-anatomy-of-oculomotion
#9
Thomas Parr, Karl J Friston
Given that eye movement control can be framed as an inferential process, how are the requisite forces generated to produce anticipated or desired fixation? Starting from a generative model based on simple Newtonian equations of motion, we derive a variational solution to this problem and illustrate the plausibility of its implementation in the oculomotor brainstem. We show, through simulation, that the Bayesian filtering equations that implement 'planning as inference' can generate both saccadic and smooth pursuit eye movements...
January 30, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29404262/tuberculum-sellae-meningioma-resection-technical-nuances-on-the-frontopterional-approach
#10
Oriela Rustemi, Renato Scienza, Alessandro Della Puppa
Tuberculum sellae meningioma remains a surgical challenge. Deep location of tumor, vascular and nerve encasement, and pituitary stalk involvement are the main technical issues. The frontopterional approach represents a natural, simple, and elegant approach to this area enabling surgeon to have a direct control on all anatomical structures. A 42-year-old woman was referred with a delayed diagnosis of tuberculum sellae meningioma due to the presence of HLA-B27-associated uveitis. She presented with 1/10 visual acuity in the left eye and no right visual function...
February 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29403349/group-analysis-in-mne-python-of-evoked-responses-from-a-tactile-stimulation-paradigm-a-pipeline-for-reproducibility-at-every-step-of-processing-going-from-individual-sensor-space-representations-to-an-across-group-source-space-representation
#11
Lau M Andersen
An important aim of an analysis pipeline for magnetoencephalographic data is that it allows for the researcher spending maximal effort on making the statistical comparisons that will answer the questions of the researcher, while in turn spending minimal effort on the intricacies and machinery of the pipeline. I here present a set of functions and scripts that allow for setting up a clear, reproducible structure for separating raw and processed data into folders and files such that minimal effort can be spend on: (1) double-checking that the right input goes into the right functions; (2) making sure that output and intermediate steps can be accessed meaningfully; (3) applying operations efficiently across groups of subjects; (4) re-processing data if changes to any intermediate step are desirable...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29380757/cornea-and-anterior-eye-assessment-with-slit-lamp-biomicroscopy-specular-microscopy-confocal-microscopy-and-ultrasound-biomicroscopy
#12
REVIEW
Raul Martin
Current corneal assessment technologies make the process of corneal evaluation extremely fast and simple, and several devices and technologies show signs that help in identification of different diseases thereby, helping in diagnosis, management, and follow-up of patients. The purpose of this review is to present and update readers on the evaluation of cornea and ocular surface. This first part reviews a description of slit lamp biomicroscopy (SLB), endothelial specular microscopy, confocal microscopy, and ultrasound biomicroscopy examination techniques and the second part describes the corneal topography and tomography, providing up-to-date information on the clinical recommendations of these techniques in eye care practice...
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29380756/anatomy-of-cornea-and-ocular-surface
#13
REVIEW
Mittanamalli S Sridhar
Important functions of cornea in the eye include protecting the structures inside the eye, contributing to the refractive power of the eye, and focusing light rays on the retina with minimum scatter and optical degradation. Considerable advances have taken place in understanding the organization of collagen in the corneal stroma and its clinical significance. In this review, the structure and function of various components of cornea and ocular surface are presented.
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29380518/ocular-anatomy-of-the-black-pacu-colossoma-macropomum-gross-histologic-and-diagnostic-imaging
#14
Kate A Gustavsen, Joanne R Paul-Murphy, Ernest Scott Weber, Allison L Zwingenberger, Freeland H Dunker, Richard R Dubielzig, Christopher M Reilly, Christopher J Murphy
OBJECTIVE: To describe the ocular anatomy of the black pacu (Colossoma macropomum), a freshwater teleost fish of the Amazon River basin, including an unusual choroid laden with adipose tissue. PROCEDURES: Three adult black pacu were anesthetized and examined clinically and with ocular ultrasonography, then euthanized. Three fish were euthanized and their heads imaged immediately postmortem using computed tomography. One fish was euthanized and its exenterated eyes imaged by high-resolution magnetic resonance imaging...
January 30, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29374584/cataract-phacoemulsification-and-intraocular-pressure-is-the-anterior-segment-anatomy-the-missing-piece-of-the-puzzle
#15
REVIEW
Marisse Masis, Shan C Lin
Cataract extraction is a safe and effective surgery that has a lowering effect on the intraocular pressure. The specific mechanisms for this effect are still unclear. A direct inflammatory effect on the trabecular meshwork, alteration of the blood aqueous barrier, changes in the ciliary body and mechanical changes of the anterior segment anatomy are the key to understand cataract surgery and it's effects on aqueous humor dynamics. Additionally, with the advent of AS OCT, changes in the anterior segment of the eye have been studied and several parameters (such as lens vault, angle opening distance and anterior chamber depth) have been identified as predictors of intraocular pressure change...
January 25, 2018: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29366504/diagnostic-imaging-in-neuro-ophthalmology
#16
A C Vela Marín, P Seral Moral, C Bernal Lafuente, B Izquierdo Hernández
Neuro-ophthalmology is a field combining neurology and ophthalmology that studies diseases that affect the visual system and the mechanisms that control eye movement and pupil function. Imaging tests make it possible to thoroughly assess the relevant anatomy and disease of the structures that make up the visual pathway, the nerves that control eye and pupil movement, and the orbital structures themselves. This article is divided into three sections (review of the anatomy, appropriate imaging techniques, and evaluation of disease according to clinical symptoms), with the aim of providing useful tools that will enable radiologists to choose the best imaging technique for the differential diagnosis of patients' problems to reach the correct diagnosis of their disease...
January 20, 2018: Radiología
https://www.readbyqxmd.com/read/29360686/three-dimensional-analysis-of-retinal-microaneurysms-with-adaptive-optics-optical-coherence-tomography
#17
Sonja G Karst, Matthias Salas, Julia Hafner, Christoph Scholda, Wolf-Dieter Vogl, Wolfgang Drexler, Michael Pircher, Ursula Schmidt-Erfurth
PURPOSE: To characterize retinal microaneurysms (MAs) in patients with diabetes using adaptive optics optical coherence tomography (AOOCT) and compare details found in AOOCT with those found in commercially available retinal imaging techniques. METHODS: Patients with diabetes and MA in the macular area were included in this pilot study. The area of interest, identified in standard fluorescein angiography, was imaged using an AO fundus camera and AOOCT. Microaneurysms were characterized in AOOCT (visibility, reflectivity, feeding/draining vessels, and intraretinal location) and compared with findings in AO fundus camera, OCT angiography, and fluorescein angiography...
January 19, 2018: Retina
https://www.readbyqxmd.com/read/29359110/the-interrelationship-between-refractive-error-blood-vessel-anatomy-and-glaucomatous-visual-field-loss
#18
Mengyu Wang, Qingying Jin, Hui Wang, Dian Li, Neda Baniasadi, Tobias Elze
Purpose: We quantified the interrelationship between retinal blood vessel (BV) anatomical variation, spherical equivalent (SE) of refractive error, and functional diagnostic parameters in glaucoma to identify optimal parameters for the improvement of optical coherence tomography (OCT) retinal nerve fiber layer thickness (RNFLT) norms. Methods: A trained observer marked the intersections of the main superior/inferior temporal arteries and veins with concentric circles around the optic nerve head (ONH) center on fundus images...
January 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29352993/comparison-of-chorioretinal-layers-in-rhesus-macaques-using-spectral-domain-optical-coherence-tomography-and-high-resolution-histological-sections
#19
Glenn Yiu, Zhe Wang, Christian Munevar, Eric Tieu, Bradley Shibata, Brittany Wong, David Cunefare, Sina Farsiu, Jeffrey Roberts, Sara Thomasy
Nonhuman primates are important preclinical models of retinal diseases because they uniquely possess a macula similar to humans. Ocular imaging technologies such as spectral-domain optical coherence tomography (SD-OCT) allow noninvasive, in vivo measurements of chorioretinal layers with near-histological resolution. However, the boundaries are based on differences in reflectivity, and detailed correlations with histological tissue layers have not been explored in rhesus macaques, which are widely used for biomedical research...
January 15, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29343781/ocular-and-clinical-characteristics-associated-with-the-extent-of-posterior-lamina-cribrosa-curve-in-normal-tension-glaucoma
#20
Seung Hyen Lee, Tae-Woo Kim, Eun Ji Lee, Michaël J A Girard, Jean Martial Mari, Robert Ritch
Although normal-tension glaucoma (NTG) is pathogenetically heterogenous, there have been few attempts to subclassify NTG patients according to the mechanism and anatomy of optic nerve damage. This cross-sectional study was performed to investigate differences in the clinical and ocular characteristics between NTG patient groups stratified according to the degree of posterior lamina cribrosa (LC) curve which was assessed by calculating LC curvature index (LCCI). A total of 101 eyes of 101 treatment naïve NTG patients were included...
January 17, 2018: Scientific Reports
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