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https://www.readbyqxmd.com/read/29232333/structural-analysis-and-comprehensive-surgical-outcomes-of-the-sutureless-intrascleral-fixation-of-secondary-intraocular-lenses-in-human-eyes
#1
Bozho Todorich, Maxwell S Stem, Keshav Kooragayala, Aristomenis Thanos, Lisa J Faia, George A Williams, Tarek S Hassan, Maria A Woodward, Jeremy D Wolfe
PURPOSE: To describe surgical outcomes and structural characteristics of intraocular lenses (IOLs) implanted with transconjunctival sutureless intrascleral (SIS) fixation in human eyes. DESIGN: Retrospective interventional surgical case series involving live and cadaveric human eyes. METHODS: In this study, we investigated the surgical outcomes and structural anatomy of secondary IOLs implanted with the SIS technique in human eyes. All cases involving SIS IOL fixation performed at a single academic center from January 1, 2012, through July 30, 2016, were reviewed to describe the surgical technique, common indications, clinical outcomes, and the rate of common operative complications...
December 11, 2017: Retina
https://www.readbyqxmd.com/read/29229445/optical-coherence-tomography-angiography
#2
REVIEW
Richard F Spaide, James G Fujimoto, Nadia K Waheed, Srinivas R Sadda, Giovanni Staurenghi
Optical coherence tomography (OCT) was one of the biggest advances in ophthalmic imaging. Building on that platform, OCT angiography (OCTA) provides depth resolved images of blood flow in the retina and choroid with levels of detailed far exceeding that obtained with older forms of imaging. This new modality is challenging because of the need for new equipment and processing techniques, current limitations of imaging capability, and rapid advancements in both imaging and in our understanding of the imaging and applicable pathophysiology of the retina and choroid, and the requirement for understanding the origins of image artifacts...
December 8, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29193569/9-4t-and-17-6t-mri-of-retinoblastoma-ex-vivo-evaluation-of-microstructural-anatomy-and-disease-extent-compared-with-histopathology
#3
Marcus C de Jong, Pim de Graaf, Petra J W Pouwels, Jan-Willem Beenakker, Robin W Jansen, Jeroen J G Geurts, Annette C Moll, Jonas A Castelijns, Paul van der Valk, Louise van der Weerd
BACKGROUND: Retinoblastoma is the most common intraocular tumor in childhood with a good prognosis in terms of mortality, but detailed information about tumor morphology and disease extent in retinoblastoma is important for treatment decision making. PURPOSE: To demonstrate ultrahigh-field MRI tumor morphology and tumor extent in retinoblastoma correlating with in and ex vivo images with histopathology. STUDY TYPE: Prospective case series...
November 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29190328/the-computational-anatomy-of-visual-neglect
#4
Thomas Parr, Karl J Friston
Visual neglect is a debilitating neuropsychological phenomenon that has many clinical implications and-in cognitive neuroscience-offers an important lesion deficit model. In this article, we describe a computational model of visual neglect based upon active inference. Our objective is to establish a computational and neurophysiological process theory that can be used to disambiguate among the various causes of this important syndrome; namely, a computational neuropsychology of visual neglect. We introduce a Bayes optimal model based upon Markov decision processes that reproduces the visual searches induced by the line cancellation task (used to characterize visual neglect at the bedside)...
November 28, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29190246/optical-coherence-tomography-angiography-findings-of-deep-capillary-plexus-microischemia-after-intravenous-chemotherapy-for-retinoblastoma
#5
Kareem Sioufi, Emil A T Say, Sandor C Ferenczy, Ann M Leahey, Carol L Shields
PURPOSE: To study changes in the foveal microvascular anatomy using optical coherence tomography angiography (OCTA) after intravenous chemotherapy (IVC) for retinoblastoma (RB). METHODS: A retrospective comparative case-control series included 10 age-matched normal eyes with no documented ocular pathology (control), 10 fellow eyes of patients with unilateral RB treated with IVC (RB fellow), and 10 eyes with extramacular RB in patients with bilateral RB treated with IVC (RB tumor)...
November 22, 2017: Retina
https://www.readbyqxmd.com/read/29190029/3d-histomorphometric-reconstruction-and-quantification-of-the-optic-nerve-head-connective-tissues
#6
Hongli Yang, Juan Reynaud, Howard Lockwood, Galen Williams, Christy Hardin, Luke Reyes, Stuart K Gardiner, Claude F Burgoyne
Accurately characterizing the 3D geometry of the optic nerve head neural and connective tissues has been the goal of a large and important body of scientific work. In the present report, we summarize our methods for the high-resolution, digital, 3D histomorphometric reconstruction of the optic nerve head tissues, including their visualization, parameterization, and quantification. In addition, we present our methods for between-eye comparisons of this anatomy, and their use to determine animal-specific and experiment-wide experimental glaucoma versus Control eye differences in the unilateral, monkey experimental glaucoma model...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29186510/the-european-bioinformatics-institute-in-2017-data-coordination-and-integration
#7
Charles E Cook, Mary T Bergman, Guy Cochrane, Rolf Apweiler, Ewan Birney
The European Bioinformatics Institute (EMBL-EBI) supports life-science research throughout the world by providing open data, open-source software and analytical tools, and technical infrastructure (https://www.ebi.ac.uk). We accommodate an increasingly diverse range of data types and integrate them, so that biologists in all disciplines can explore life in ever-increasing detail. We maintain over 40 data resources, many of which are run collaboratively with partners in 16 countries (https://www.ebi.ac.uk/services)...
November 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29176786/in-vivo-imaging-of-palisades-of-vogt-in-dry-eye-versus-normal-subjects-using-en-face-spectral-domain-optical-coherence-tomography
#8
Wajdene Ghouali, Rachid Tahiri Joutei Hassani, Zoubir Djerada, Hong Liang, Mohamed El Sanharawi, Antoine Labbé, Christophe Baudouin
PURPOSE: To evaluate a possible clinical application of spectral-domain optical coherence tomography (SD-OCT) using en-face module for the imaging of the corneoscleral limbus in normal subjects and dry eye patients. PATIENTS AND METHODS: Seventy-six subjects were included in this study. Seventy eyes of 35 consecutive patients with dry eye disease and 82 eyes of 41 healthy control subjects were investigated. All subjects were examined with the Avanti RTVue® anterior segment OCT...
2017: PloS One
https://www.readbyqxmd.com/read/29175499/visualization-of-porcine-eye-anatomy-by-x-ray-microtomography
#9
Bartosz Leszczyński, Paulina Sojka-Leszczyńska, Dorota Wojtysiak, Andrzej Wróbel, Roman Pędrys
The aim of our study is to obtain, as accurately as possible, porcine ocular tissue visualization using microtomography (micro-CT) method. We propose image contrast enhancement by different staining procedures with combination of micro-CT scanning. Porcine eye globes were investigated with Bruker-SkyScan 1172 micro-CT. We used 4F1G and Bouin's as sample fixation solutions and tincture of iodine, 100% Lugol, phosphotungstic acid and 1% osmium tetroxide solutions for staining. Quantitative and qualitative analysis was performed based on micro-CT reconstruction images histograms and 3D volume rendering models of investigated samples...
November 22, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29169882/reproducibility-of-vessel-density-fractal-dimension-and-foveal-avascular-zone-using-7-different-optical-coherence-tomography-angiography-devices
#10
Federico Corvi, Marco Pellegrini, Stefano Erba, Mariano Cozzi, Giovanni Staurenghi, Andrea Giani
PURPOSE: To evaluate the reproducibility of parafoveal microvascular anatomy of 7 different optical coherence tomography angiography (OCT-A) devices by comparing vessels density (VD), fractal dimension (FD) and foveal avascular zone (FAZ) of superficial and deep capillary plexus in healthy volunteers. DESIGN: Reliability analysis. METHODS: Consecutive healthy volunteers presenting at the Eye Clinic, Department of Biomedical and Clinical Sciences, Luigi Sacco Hospital, University of Milan in the same clinic visit were imaged by 7 different OCT-A devices: Optovue RTVue XR Avanti (Optovue, Inc, Fremont, CA), prototype Spectralis OCT-A (Spectralis Heidelberg Engineering, Heidelberg, Germany), AngioPlex (Cirrus 5000 HD-OCT, Carl Zeiss Meditec, Inc), prototype PlexElite (Carl Zeiss Meditec, Dublin, CA), RS-3000 Advance (Nidek, Gamagori, Japan), OCT-HS100 (Canon, Tokyo, Japan) and Revo NX (Optopol technology SA, Zawiercie, Poland)...
November 20, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29164019/quantitative-analysis-of-electro-anatomical-maps-application-to-an-experimental-model-of-left-bundle-branch-block-cardiac-resynchronization-therapy
#11
David Soto Iglesias, Nicolas Duchateau, Constantine Butakoff Kostantyn Butakov, David Andreu, Juan Fernandez-Armenta, Bart Bijnens, Antonio Berruezo, Marta Sitges, Oscar Camara
Electro-anatomical maps (EAMs) are commonly acquired in clinical routine for guiding ablation therapies. They provide voltage and activation time information on a 3-D anatomical mesh representation, making them useful for analyzing the electrical activation patterns in specific pathologies. However, the variability between the different acquisitions and anatomies hampers the comparison between different maps. This paper presents two contributions for the analysis of electrical patterns in EAM data from biventricular surfaces of cardiac chambers...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29141537/ophthalmic-applications-of-sln-and-nlc
#12
Neslihan Ustundag Okur, Evren Homan Gokce
BACKGROUND: The eyes are among the most readily accessible organs in terms of location in the body, yet drug delivery to eye tissues is particularly problematic. The anatomy, physiology and biochemistry of the eye limit the ophthalmic delivery of drugs. Numerous strategies in ophthalmic drug delivery have been made to expand the bioavailability and to prolong the remaining time of drugs treated topically to eye. METHODS: Designing a novel delivery vehicles that can proficiently target the diseased eye tissue, generate high drug levels, and keep sustained and effective concentrations with no or minimum side effects is the main concentration of present examination...
November 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29120718/wound-healing-in-rabbit-corneas-after-flapless-refractive-lenticule-extraction-with-a-345%C3%A2-nm-ultraviolet-femtosecond-laser
#13
Christian M Hammer, Corinna Petsch, Jörg Klenke, Katrin Skerl, Christian Wüllner, Christof Donitzky, Friedrich Paulsen, Michael Scholz, Theo Seiler, Friedrich E Kruse, Johannes Menzel-Severing
PURPOSE: To characterize corneal wound healing in a rabbit model after flapless refractive lenticule extraction with a 345 nm ultraviolet femtosecond laser. SETTING: Departments of Ophthalmology and Anatomy II, University of Erlangen-Nürnberg and Wavelight GmbH, Erlangen, Germany. DESIGN: Experimental study. METHODS: Flapless refractive lenticule extraction was performed in 1 eye each of 20 New Zealand white rabbits (-5...
October 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29114939/three-dimensional-endoscopy-for-endoscopic-salvage-nasopharyngectomy-preliminary-report-of-experience
#14
Jimmy Yu Wai Chan, William Ignace Wei
BACKGROUND: Prospective, observational study to assess the efficacy of salvage nasopharyngectomy for recurrent nasopharyngeal carcinoma (NPC) via the endoscopic endonasal approach using a three-dimensional (3D) high-definition endoscopic system. METHODS: Between 2016 and 2017, 30 patients with recurrent NPC were recruited. Patient demographics, tumor characteristics, and perioperative data were recorded. Instrument ergonomics and perceived advantages were assessed by the operating, assisting, and observing surgeons...
November 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29112798/perceptions-of-first-year-medical-students-towards-learning-anatomy-using-cadaveric-specimens-through-peer-teaching
#15
Andee Agius, Neville Calleja, Christian Camenzuli, Roberta Sultana, Richard Pullicino, Christian Zammit, Jean Calleja Agius, Cristoforo Pomara
During the last decade, global interest in the multiple benefits of formal peer teaching has increased. This study aimed to explore the perceptions of first-year medical students towards the use of peer teaching to learn anatomy using cadaveric specimens. A descriptive, cross-sectional, retrospective survey was carried out. Data were collected using an online questionnaire which was administered to all medical students who were in their second year of their medical school curriculum and who had participated in sessions taught by their peers during their first year...
November 7, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/29103559/the-equine-fundus
#16
REVIEW
Gil Ben-Shlomo
Fundus is an anatomic term referring to the portion of an organ opposite from its opening, and the fundus of the eye is the back portion of the posterior segment of the globe, including the optic nerve, retina, and choroid. Clinically, the fundus can be visualized by direct or indirect ophthalmoscopy. Understanding the normal anatomy and appearance of the equine fundus is crucial for differentiating normal variations from abnormalities. This article reviews the normal anatomy and appearance of the equine fundus and discusses basic and advanced examination techniques...
December 2017: Veterinary Clinics of North America. Equine Practice
https://www.readbyqxmd.com/read/29069259/endoscopic-endonasal-approach-for-mass-resection-of-the-pterygopalatine-fossa
#17
Jan Plzák, Vít Kratochvil, Adam Kešner, Pavol Šurda, Aleš Vlasák, Eduard Zvěřina
OBJECTIVES: Access to the pterygopalatine fossa is very difficult due to its complex anatomy. Therefore, an open approach is traditionally used, but morbidity is unavoidable. To overcome this problem, an endoscopic endonasal approach was developed as a minimally invasive procedure. The surgical aim of the present study was to evaluate the utility of the endoscopic endonasal approach for the management of both benign and malignant tumors of the pterygopalatine fossa. METHOD: We report our experience with the endoscopic endonasal approach for the management of both benign and malignant tumors and summarize recent recommendations...
October 2017: Clinics
https://www.readbyqxmd.com/read/29068912/optical-coherence-tomography-angiography-to-detect-macular-capillary-ischemia-in-patients-with-inner-retinal-changes-after-resolved-diabetic-macular-edema
#18
Hamid-Reza Moein, Eduardo A Novais, Carl B Rebhun, Emily D Cole, Ricardo N Louzada, André J Witkin, Caroline R Baumal, Jay S Duker, Nadia K Waheed
PURPOSE: To compare foveal vascular anatomy between patients with and without disorganization of retinal inner layers (DRILs) after resolved diabetic macular edema using optical coherence tomography angiography (OCTA). METHODS: Twenty-four eyes of 21 age- and sex-matched patients with resolved diabetic macular edema were included in this retrospective, cross-sectional study. All eyes were imaged with enhanced high-definition line or cross-line structural B scans and 3 × 3-mm OCTA scans...
October 24, 2017: Retina
https://www.readbyqxmd.com/read/29049728/surgically-induced-focal-retinal-detachment-does-not-cause-detectable-sd-oct-retinal-changes-in-normal-human-retina
#19
MULTICENTER STUDY
Kaitlin Kogachi, Jeremy D Wolfe, Amir H Kashani
Purpose: Induction of focal retinal detachment (RD) for subretinal delivery of stem cells and gene therapy is increasingly common. In order to determine if this procedure has an adverse impact on the retina, we use spectral-domain optical coherence tomography (SD-OCT) to evaluate the pre- and postoperative retinal anatomy of the incidentally detached normal retina surrounding large submacular hemorrhages (SMH) during surgical displacement procedures. Methods: Retrospective, observational study of human subjects with monocular SMH evaluated before and after surgical displacement using clinical exam, fundus photography, and SD-OCT...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29049501/optical-coherence-tomography-angiography-for-assessment-of-the-3-dimensional-structures-of-polypoidal-choroidal-vasculopathy
#20
Yu-Tien Chi, Chang-Hao Yang, Cheng-Kuo Cheng
Importance: Investigating the quantitative 3-dimensional (3-D) anatomy of polypoidal complex is important for a better understanding of the pathogenesis of polypoidal choroidal vasculopathy (PCV). Objective: To quantitatively evaluate the 3-D characteristics of polypoidal structures, branching vascular networks (BVNs), and origin of PCV using optical coherence tomography angiography (OCTA) and multiple image systems. Design, Setting, and Participants: A prospective, observational study was conducted in 47 consecutive Taiwanese patients (47 eyes) from May 21, 2015, to April 30, 2017...
October 19, 2017: JAMA Ophthalmology
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