Huihui Ren, Tengyan Xu, Kun Liang, Jiye Li, Yu Fang, Fanfan Li, Yitong Chen, Hongyue Zhang, Dingwei Li, Yingjie Tang, Yan Wang, Chunyan Song, Huaimin Wang, Bowen Zhu
Flexible biosensors have received intensive attention for real-time, non-invasive monitoring of cancer biomarkers. Highly sensitive tyrosinase biosensors, which are important for melanoma screening, remained a hurdle. Herein, high-performance tyrosinase-sensing field-effect transistor-based biosensors (bio-FETs) have been successfully achieved by self-assembling nanostructured tetrapeptide tryptophan-valine-phenylalanine-tyrosine (WVFY) on n-type metal oxide transistors. In the presence of target tyrosinase, the phenolic hydroxyl groups in WVFY are rapidly converted to benzoquinone with the consumption of protons, which could be detected potentiometrically by bio-FETs...
January 21, 2022: IScience