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JOURNAL ARTICLE
Elisabeth Victoria Goessinger, Johannes-Christian Niederfeilner, Sara Cerminara, Julia-Tatjana Maul, Lisa Kostner, Michael Kunz, Stephanie Huber, Emrah Koral, Lea Habermacher, Gianna Sabato, Andrea Tadic, Carmina Zimmermann, Alexander Navarini, Lara Valeska Maul
BACKGROUND: Artificial intelligence (AI) shows promising potential to enhance human decision-making as synergistic augmented intelligence (AuI), but requires critical evaluation for skin cancer screening in a real-world setting. OBJECTIVES: To investigate the perspectives of patients and dermatologists after skin cancer screening by human, artificial and augmented intelligence. METHODS: A prospective comparative cohort study conducted at the University Hospital Basel included 205 patients (at high-risk of developing melanoma, with resected or advanced disease) and 8 dermatologists...
February 27, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
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JOURNAL ARTICLE
Health Economic Consequences Associated With COVID-19-Related Delay in Melanoma Diagnosis in Europe.
Lara V Maul, Dagmar Jamiolkowski, Rebecca A Lapides, Alina M Mueller, Axel Hauschild, Claus Garbe, Paul Lorigan, Jeffrey E Gershenwald, Paolo Antonio Ascierto, Georgina V Long, Michael Wang-Evers, Richard A Scolyer, Babak Saravi, Matthias Augustin, Alexander A Navarini, Stefan Legge, István B Németh, Ágnes J Jánosi, Simone Mocellin, Anita Feller, Dieter Manstein, Alexander Zink, Julia-Tatjana Maul, Alessandra Buja, Kaustubh Adhikari, Elisabeth Roider
IMPORTANCE: The COVID-19 pandemic resulted in delayed access to medical care. Restrictions to health care specialists, staff shortages, and fear of SARS-CoV-2 infection led to interruptions in routine care, such as early melanoma detection; however, premature mortality and economic burden associated with this postponement have not been studied yet. OBJECTIVE: To determine the premature mortality and economic costs associated with suspended melanoma screenings during COVID-19 pandemic lockdowns by estimating the total burden of delayed melanoma diagnoses for Europe...
February 5, 2024: JAMA Network Open
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JOURNAL ARTICLE
Celia Barrio-Alonso, Alicia Nieto-Valle, Elena García-Martínez, Alba Gutiérrez-Seijo, Verónica Parra-Blanco, Iván Márquez-Rodas, José Antonio Avilés-Izquierdo, Paloma Sánchez-Mateos, Rafael Samaniego
During cancer evolution, tumor cells attract and dynamically interact with monocytes/macrophages. To find biomarkers of disease progression in human melanoma, we used unbiased RNA sequencing and secretome analyses of tumor-macrophage co-cultures. Pathway analysis of genes differentially modulated in human macrophages exposed to melanoma cells revealed a general upregulation of inflammatory hallmark gene sets, particularly chemokines. A selective group of chemokines, including CCL8, CCL15, and CCL20, was actively secreted upon melanoma-macrophage co-culture...
January 30, 2024: Journal of Pathology
#4
JOURNAL ARTICLE
Madeleine E Crawford, Kiyana Kamali, Rachel A Dorey, Olivia C MacIntyre, Kristyna Cleminson, Michael L MacGillivary, Peter J Green, Richard G Langley, Kerri S Purdy, Ryan C DeCoste, Jennette R Gruchy, Sylvia Pasternak, Amanda Oakley, Peter R Hull
INTRODUCTION: Early detection of melanoma requires timely access to medical care. In this study, we examined the feasibility of using artificial intelligence (AI) to flag possible melanomas in self-referred patients concerned that a skin lesion might be cancerous. METHODS: Patients were recruited for the study through advertisements in 2 hospitals in Halifax, Nova Scotia, Canada. Lesions of concern were initially examined by a trained medical student and if the study criteria were met, the lesions were then scanned using the FotoFinder System® ...
December 29, 2023: Journal of Cutaneous Medicine and Surgery
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EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
December 20, 2023: British Journal of Dermatology
#6
JOURNAL ARTICLE
Kate L A Dunlop, Louise A Keogh, Andrea L Smith, Sanchia Aranda, Joanne Aitken, Caroline G Watts, Amelia K Smit, Monika Janda, Graham J Mann, Anne E Cust, Nicole M Rankin
INTRODUCTION: In Australia, opportunistic screening (occurring as skin checks) for the early detection of melanoma is common, and overdiagnosis is a recognised concern. Risk-tailored cancer screening is an approach to cancer control that aims to provide personalised screening tailored to individual risk. This study aimed to explore the views of key informants in Australia on the acceptability and appropriateness of risk-tailored organised screening for melanoma, and to identify barriers, facilitators and strategies to inform potential future implementation...
2023: PloS One
#7
JOURNAL ARTICLE
Brigid Betz-Stablein, H Peter Soyer
No abstract text is available yet for this article.
October 1, 2023: Dermatology Practical & Conceptual
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JOURNAL ARTICLE
Xueqin Huang, Lingzhi Chen, Tianjian Sha, Yongjian Lin, Runmin Zeng, Jun Xu, Shanze Chen, Huai-Hong Cai, Jianglin Zhang, Haibo Zhou, Ping-Hua Sun, Xingyu Jiang
Despite the potential indicating role of tyrosinase (TYR) in cutaneous melanoma, how to capture the real changes of TYR in suspicious skin remains a major challenge. Unlike the traditional human serum test, this study reports a sensing platform that incorporates a wearable microneedle (MN) patch and trimetallic Au@Ag-Pt nanoparticles (NPs) for surface-enhanced Raman scattering (SERS) and colorimetric dual-mode detecting TYR in human skin in situ toward potential melanoma screening. In the presence of TYR, catechol immobilized on MN is preferentially oxidized to benzoquinone, which competitively impedes the interaction of MN and Au@Ag-Pt NPs, triggering the SERS-colorimetric signal reciprocal switch...
October 4, 2023: ACS Nano
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JOURNAL ARTICLE
Collin M Costello, Stephen W Dusza, Ashfaq A Marghoob, Allan C Halpern
No abstract text is available yet for this article.
September 2, 2023: Journal of the American Academy of Dermatology
#10
JOURNAL ARTICLE
Courtney K Wallingford, Ellie J Maas, Antonia Howard, Emily DeBortoli, Deboshmita Bhanja, Katie Lee, Adam Mothershaw, Kasturee Jagirdar, Rod Willett, Brigid Betz-Stablein, Richard A Sturm, H Peter Soyer, Aideen M McInerney-Leo
MITF E318K moderates melanoma risk. Only five MITF E318K homozygous cases have been reported to date, one in association with melanoma. This novel report uses 3D total-body-photography (TBP) to describe the dermatological phenotype of a homozygous MITF E318K individual. The case, a 32-year-old male, was diagnosed with his first of six primary melanomas at 26 years of age. Five melanomas were located on the back and one in the groin. Two were superficial spreading. Three arose from pre-existing naevi and one was a rare naevoid melanoma...
August 27, 2023: Pigment Cell & Melanoma Research
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JOURNAL ARTICLE
Jane M Anderson, Izhaar Tejani, Tory Jarmain, Lisa Kellett, Ronald L Moy
Early diagnosis of melanoma drastically reduces morbidity and mortality; however, most skin lesions are not initially evaluated by dermatologists, and some patients may require a referral. This study sought to determine the performance of an artificial intelligence (AI) application in classifying lesions as benign or malignant to determine whether AI could assist in screening potential melanoma cases. One hundred dermoscopic images (80 benign nevi and 20 biopsy-verified malignant melanomas) were assessed by an AI application as well as 23 dermatologists, 7 family physicians, and 12 primary care mid-level providers...
May 2023: Cutis; Cutaneous Medicine for the Practitioner
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JOURNAL ARTICLE
Jenne P Ingrassia, Prince Adotama, Jennifer A Stein, David Polsky
No abstract text is available yet for this article.
June 27, 2023: Journal of the American Academy of Dermatology
#13
JOURNAL ARTICLE
Mohammed Kashani-Sabet, Sancy A Leachman, Jennifer A Stein, Jack L Arbiser, Elizabeth G Berry, Julide T Celebi, Clara Curiel-Lewandrowski, Laura K Ferris, Jane M Grant-Kels, Douglas Grossman, Rajan P Kulkarni, Michael A Marchetti, Kelly C Nelson, David Polsky, Elizabeth V Seiverling, Susan M Swetter, Hensin Tsao, Alexandra Verdieck-Devlaeminck, Maria L Wei, Anna Bar, Edmund K Bartlett, Jean L Bolognia, Tawnya L Bowles, Kelly B Cha, Emily Y Chu, Rebecca I Hartman, Elena B Hawryluk, Risa M Jampel, Lilit Karapetyan, Meenal Kheterpal, David H Lawson, Philip D Leming, Tracey N Liebman, Michael E Ming, Debjani Sahni, Stephanie A Savory, Saba S Shaikh, Arthur J Sober, Vernon K Sondak, Natalie Spaccarelli, Richard P Usatine, Suraj Venna, John M Kirkwood
IMPORTANCE: Therapy for advanced melanoma has transformed during the past decade, but early detection and prognostic assessment of cutaneous melanoma (CM) remain paramount goals. Best practices for screening and use of pigmented lesion evaluation tools and gene expression profile (GEP) testing in CM remain to be defined. OBJECTIVE: To provide consensus recommendations on optimal screening practices and prebiopsy diagnostic, postbiopsy diagnostic, and prognostic assessment of CM...
March 15, 2023: JAMA Dermatology
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JOURNAL ARTICLE
Harini Subramanian, Veronika Fuchsova, Elisabeth Elder, Alison Brand, Julie Howle, Anna DeFazio, Graham J Mann, Terence Amis, Kristina Kairaitis
BACKGROUND AND AIMS: For cancer patients, comorbid obstructive sleep apnea (OSA) poses additional risk to their surgical/anaesthetic outcomes, quality of life, and survival. However, OSA screening is not well-established in oncology settings. We tested two screening tools (STOP-Bang questionnaire [SBQ] and the at-home monitoring device, ApneaLink™Air), for predicting polysomnography (PSG) confirmed OSA in post-treatment cancer patients. METHODS: Breast (n = 56), endometrial (n = 37) and melanoma patients (n = 50) were recruited from follow-up clinics at Westmead Hospital (Sydney, Australia)...
December 13, 2022: Cancer reports
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REVIEW
Szabolcs Farkas-Ráduly, Marcell Csanádi, Tamás Ágh, Orsolya Szász, Zoltán Vokó, György Széles
INTRODUCTION: In Eastern and Central Europe, Hungary has the third highest incidence of melanoma after the Czech Republic and Slovakia. In order to improve the efficiency of melanoma diagnostics and screening, several technological developments have been made in recent years, one is the integrated automated total body mapping and digital dermatoscopy. OBJECTIVE: The aim of this targeted literature review is to demonstrate the potential of new digital technologies developed for total body mapping in relation to melanoma screening...
December 4, 2022: Orvosi Hetilap
#16
JOURNAL ARTICLE
Rachel J Mesia, Patricia Rodriguez Espinosa, Hayden Hutchison, Nadia Safaeinili, Laurel J Finster, Vijaytha Muralidharan, Beth A Glenn, Robert W Haile, Lisa Goldman Rosas, Susan M Swetter
BACKGROUND: Melanoma mortality rates in the US are highest among older men, individuals of lower socioeconomic status (SES), and people of color. To better understand these inequities, a qualitative exploratory study was conducted in Northern and Southern California to generate knowledge about barriers and facilitators of awareness, prevention, and early detection of melanoma in lower SES Latinx and non-Latinx White (NLW) individuals living in urban and semi-rural areas. METHODS: Nineteen focus groups were conducted (N = 176 adult participants), stratified by race/ethnicity (Latinx, low-income NLW), geography (semi-rural, urban), and language (English and Spanish)...
November 25, 2022: Cancer Medicine
#17
JOURNAL ARTICLE
Carmen Cantisani, Luca Ambrosio, Carlotta Cucchi, Fanni Adél Meznerics, Norbert Kiss, András Bánvölgyi, Federica Rega, Flavia Grignaffini, Francesco Barbuto, Fabrizio Frezza, Giovanni Pellacani
INTRODUCTION: The incidence of melanoma increased considerably in recent decades, representing a significant public health problem. We aimed to evaluate the ability of non-specialists for the preliminary screening of skin lesions to identify melanoma-suspect lesions. MATERIALS AND METHODS: A medical student and a dermatologist specialist examined the total body scans of 50 patients. RESULTS: The agreement between the expert and the non-specialist was 87...
November 16, 2022: Diagnostics
#18
JOURNAL ARTICLE
Marcin Ziętek, Jędrzej Wierzbicki, Edyta Pawlak, Adam Maciejczyk, Rafał Matkowski
BACKGROUND: In recent years, benchmarking and assessment methods to improve the quality of care have become increasingly important. Such approaches allow for a uniform assessment, comparisons between centers or over time, and the identification of weaknesses. In this study, the results of a 20-month pilot program to assess, monitor and improve the quality of care in melanoma patients primarily treated surgically are presented. METHODS: The pilot program started in May 2020 at the Lower Silesian Oncology, Pulmonology and Hematology Center (LSOPHC) in Wroclaw, Poland (Lower Silesian Voivodeship, southwestern province of Poland with a population of 2,9 million)...
November 23, 2022: BMC Cancer
#19
REVIEW
Sarem Rashid, Michael Shaughnessy, Hensin Tsao
Melanoma is the most lethal form of skin cancer although surgery is often curative when combined with early screening and prevention. In recurrent or advanced cancer, the emergence of chemotherapy, targeted therapy, and immune checkpoint inhibitors has demonstrated promising clinical outcomes. Such approaches can remarkably halt the progression of disease for many years, although are limited by the acquisition of resistance. The development and approval of combination therapies has further changed the treatment paradigm for certain melanomas...
January 2023: Dermatologic Clinics
#20
JOURNAL ARTICLE
Robert A Swerlick
No abstract text is available yet for this article.
September 21, 2022: JAMA Dermatology
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