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"Melanoma screening"

Daniel S Gareau, Joel Correa da Rosa, Sarah Yagerman, John A Carucci, Nicholas Gulati, Ferran Hueto, Jennifer L DeFazio, Mayte Suárez-Fariñas, Ashfaq Marghoob, James G Krueger
We developed an automated approach for generating quantitative image analysis metrics (imaging biomarkers) that are then analysed with a set of 13 machine learning algorithms to generate an overall risk score that is called a Q-score. These methods were applied to a set of 120 "difficult" dermoscopy images of dysplastic nevi and melanomas that were subsequently excised/classified. This approach yielded 98% sensitivity and 36% specificity for melanoma detection, approaching sensitivity/specificity of expert lesion evaluation...
October 26, 2016: Experimental Dermatology
Joachim Mikkelsen, Steen Henrik Matzen
INTRODUCTION: Cancer is a recognized risk factor of venous thromboembolism (VTE) as it induces a prothrombotic state through various mechanisms of activation of coagulation. Recognizing occult cancer as a risk factor is equally important. In patients with no known thromboembolic risk factors, utilizing PET/CT as a screening tool may be considered in order to reveal occult malignancy associated with otherwise unexplainable VTE. METHODS: This case report has been reported in line with the SCARE criteria...
October 14, 2016: International Journal of Surgery Case Reports
Jonathon Pleat
No abstract text is available yet for this article.
October 2016: Lancet Oncology
M A Weinstock, J P Lott, Q Wang, L J Titus, T Onega, H D Nelson, L Pearson, M Piepkorn, J G Elmore, A N A Tosteson
BACKGROUND:  Melanoma incidence has increased in recent decades in the United States. Uncertainty remains regarding how much of this increase is attributable to greater melanoma screening activities, potential detection bias and overdiagnosis. OBJECTIVE: Use a cross-sectional ecological analysis to evaluate the relationship between skin biopsy and melanoma incidence rates over a more recent time period than prior reports. METHODS: Examination of the association of biopsy rates and melanoma incidence (invasive and in situ) in SEER-Medicare data (including 10 states) for 2002-2009...
September 17, 2016: British Journal of Dermatology
Sean M Dawes, Sheena Tsai, Haley Gittleman, Jill S Barnholtz-Sloan, Jeremy S Bordeaux
BACKGROUND: Melanoma is a cutaneous malignancy common in the white population but can also occur in other racial groups. OBJECTIVE: We sought to evaluate survival across racial groups in patients given a diagnosis of malignant melanoma. METHODS: The Surveillance, Epidemiology, and End Results database was used to populate a cohort of 96,953 patients given a diagnosis of cutaneous melanoma as their primary cancer, from 1992 to 2009. RESULTS: White patients had the longest survival time (P < ...
November 2016: Journal of the American Academy of Dermatology
Cédric Rat, Gaelle Quereux, Charlotte Grimault, Jérémy Fernandez, Mickael Poiraud, Aurélie Gaultier, Anicet Chaslerie, Jacques Pivette, Amir Khammari, Brigitte Dreno, Jean-Michel Nguyen
OBJECTIVE: The study objective was to measure the rates of inclusion of populations at risk of advanced melanoma in a pilot targeted screening project involving general practitioners. DESIGN: This cross-sectional database study compared the inclusion rates of patients who signed inclusion in a targeted screening project with those of patients who did not, during a period in which both groups of patients consulted investigators. SETTING: Data were extracted from the national healthcare insurance records in western France from 11 April to 30 October 2011...
September 2016: Scandinavian Journal of Primary Health Care
Alyce Jm Anderson, John M Kirkwood, Laura K Ferris
No abstract text is available yet for this article.
June 2016: Cutis; Cutaneous Medicine for the Practitioner
Clara Curiel-Lewandrowski, Susan M Swetter
No abstract text is available yet for this article.
July 8, 2016: Cancer
Martin A Weinstock, Laura K Ferris, Melissa I Saul, Alan C Geller, Patricia M Risica, Julia A Siegel, Francis X Solano, John M Kirkwood
BACKGROUND: Population-based screening for the early detection of melanoma holds great promise for reducing melanoma mortality, but evidence is needed to determine whether benefits outweigh risks. Skin surgeries and dermatology visits after screening were assessed to indicate potential physical, psychological, and financial consequences. METHODS: Targeted primary care providers (PCPs) at the University of Pittsburgh Medical Center were trained to detect early melanoma using the INFORMED (INternet course FOR Melanoma Early Detection) program...
October 15, 2016: Cancer
Maria L Marino, Cristina Carrera, Michael A Marchetti, Ashfaq A Marghoob
Early detection remains the most important strategy to reduce melanoma mortality. The identification and evaluation of new or changing skin lesions are important components of melanoma screening and are best performed today using complementary noninvasive imaging technologies, such as total body photography (TBP), dermoscopy, sequential digital dermoscopic imaging (SDDI), and reflectance confocal microscopy (RCM). Despite strong evidence showing that these screening techniques improve diagnostic accuracy for melanoma, they are not widely used by dermatologists...
July 2016: Dermatologic Clinics
Ava Socik, Autumn Burnes, Arthur R Rhodes
Importance: The presence of numerous melanocytic nevi is a significant melanoma risk factor, but there are scant data related to prevalence and morphologic features of melanocytic nevi in the perianal area. The prognosis of perianal melanoma is often dismal because of hidden location and diagnosis delay. Objective: To determine prevalence and morphologic features of perianal melanocytic nevi. Design, Setting, and Participants: This study was conducted for 11 months during 2013 and 2014 at an outpatient dermatology clinic in Chicago, Illinois, with a convenience sample of 236 adults (men and women of all races, ≥18 years) presenting to 1 dermatologist for melanoma and/or skin cancer screening or surveillance...
June 15, 2016: JAMA Dermatology
C Fink, H A Haenssle
The diagnosis of advanced cutaneous melanoma may easily be made by the unaided eye, followed by excisional biopsy and histopathological examination. However, in the setting of melanoma screening examinations in high-risk patients with many nevi, dermatologists are challenged with the differentiation of atypical but benign nevi and early invasive or in situ melanomas. In this situation, there is a real need for additional, noninvasive examination techniques that may serve as an aide to decide for or against an excisional biopsy...
July 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Zhennan Wang, Meixiu Sun, Chuji Wang
Skin cells emit volatile organic compounds (VOCs), and some of them can be used as biomarkers for screening specific diseases. Dimethyl disulfide (DMDS) has been recently reported as a biomarker of melanoma skin cancer (Kwak et al. "Volatile Biomarkers from Human Melanoma Cells". J. Chromatogr. B. 2013. 931: 90-96.). With the motivation of diagnosing melanoma using DMDS as its biomarker, we explore the potential of measuring DMDS using an advanced laser spectroscopic technique as an alternative method. We report on the first DMDS measurements using an experimental system based on cavity ringdown spectroscopy (CRDS)...
June 2016: Applied Spectroscopy
Lisa E Paddock, Shou En Lu, Elisa V Bandera, George G Rhoads, Judith Fine, Susan Paine, Raymond Barnhill, Marianne Berwick
To evaluate the effect of skin self-examination (SSE) on melanoma mortality, we estimated the survival for individuals performing SSE compared with those who did not. Participants were from a previously carried out case-control study, who were newly diagnosed melanoma cases in 1987-1989. A 20-year survival analysis was carried out using death (event) and other causes of death (competing). Cumulative incidence functions were evaluated using Gray's test and proportional subdistribution hazards regression models were fitted to study the effect of SSE and other covariates on melanoma survival...
August 2016: Melanoma Research
P Chappuis, G Duru, O Marchal, P Girier, S Dalle, L Thomas
BACKGROUND: Dermoscopy improves diagnostic accuracy in melanoma, as shown by several meta-analyses. Although it is used by general practitioners (GPs) in Australia, Canada and Italy, no published data on this topic are available in France. OBJECTIVES: To review the opinions and use of dermoscopy by GPs in France and to understand their practice of skin examination. METHODS: We designed a descriptive and cross-sectional survey and conducted it between 26 November and 26 December 2014...
October 2016: British Journal of Dermatology
Richard Shellenberger, Mohammed Nabhan, Sweta Kakaraparthi
Malignant melanoma ranks fifth in the number of new cases annually in the United States (US). Despite increasing incidence and lack of recent improvement in mortality, national melanoma screening guidelines are currently not in existence. Our purpose was to review the evidence regarding screening whole-body skin examinations for early detection and a possible mortality benefit for malignant melanoma. Data sources for our review were MEDLINE Complete, PubMed, Cochrane Library, Cochrane Database of Systematic Reviews, and ClinicalTrials...
2016: Annals of Medicine
Sarah L McFarland, Sarah E Schram
A variety of estimates of the value and impact of physician skin examinations (PSEs) in screening for melanoma have been published. Although current melanoma screening guidelines vary, new evidence supports improved melanoma outcomes associated with PSEs. In this systematic review, we evaluated 5 observational studies of the impact of PSEs on melanoma thickness at diagnosis and melanoma mortality rates. Although definitive evidence from randomized controlled trials supporting improved health outcomes associated with PSEs is lacking, these well-designed observational studies have found PSEs to be correlated with thinner melanomas at diagnosis and reduced melanoma mortality rates...
September 2015: Cutis; Cutaneous Medicine for the Practitioner
June K Robinson, Allan C Halpern
No abstract text is available yet for this article.
January 2016: JAMA Dermatology
Cédric Rat, Charlotte Grimault, Gaelle Quereux, Maelenn Dagorne, Aurélie Gaultier, Amir Khammari, Brigitte Dreno, Jean-Michel Nguyen
OBJECTIVE: To evaluate the efficacy of a targeted screening for melanoma in high-risk patients following the receipt of a mailed invitation to an annual skin examination by a general practitioner (GP). METHODS: A prospective cohort study was conducted in a primary care setting in western France. A total of 3897 patients at elevated risk of melanoma (identified using the Self-Assessment of Melanoma Risk Score) consented to participate in a targeted melanoma screening project in 2011...
July 29, 2015: BMJ Open
Jean Spinks, Monika Janda, H Peter Soyer, Jennifer A Whitty
INTRODUCTION: 'Store and forward' teledermoscopy is a technology with potential advantages for melanoma screening. Any large-scale implementation of this technology is dependent on consumer acceptance. AIM: To investigate preferences for melanoma screening options compared with skin self-examination in adults considered to be at increased risk of developing skin cancer. METHODS: A discrete choice experiment was completed by 35 consumers, all of whom had prior experience with the use of teledermoscopy, in Queensland, Australia...
January 2016: Journal of Telemedicine and Telecare
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