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https://www.readbyqxmd.com/read/29374753/xeroderma-pigmentosum-facts-and-perspectives
#1
REVIEW
Janin Lehmann, Christina Seebode, Marie Christine Martens, Steffen Emmert
Ultraviolet (UV)-induced DNA lesions are almost exclusively removed by the nucleotide excision repair (NER) pathway, which is essential for prevention of skin cancer development. Patients with xeroderma pigmentosum (XP) are extremely sun sensitive due to a genetic defect in components of the NER cascade. They present with first signs of premature skin aging at an early age, with a considerably increased risk of developing UV-induced skin cancer. XP belongs to the group of DNA repair defective disorders that are mainly diagnosed in the clinic and in hindsight confirmed at the molecular level...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29374752/photocarcinogenesis-and-skin-cancer-prevention-strategies-an-update
#2
REVIEW
Marie Christine Martens, Christina Seebode, Janin Lehmann, Steffen Emmert
UV radiation is acknowledged as the primary cause of photocarcinogenesis and therefore contributes to the development of skin cancer entities such as squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and melanoma. Typical DNA photoproducts and indirect DNA damage caused by reactive oxygen species are the result of UV radiation. UV-induced DNA damage is repaired by nucleotide excision repair, which consequently counteracts the development of mutations and skin carcinogenesis. Tumour-suppressor genes are inactivated by mutation and growth-promoting pathways are activated leading to disruption of cell-cycle progression...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29360199/trimodal-system-for-in-vivo-skin-cancer-screening-with-combined-oct-raman-and-co-localized-optoacoustic-measurements
#3
Arthur Varkentin, Mikhail Mazurenka, Elias Blumenröther, Lea Behrendt, Steffen Emmert, Uwe Morgner, Merve Meinhardt-Wollweber, Maik Rahlves, Bernhard Roth
A new multimodal system for rapid, noninvasive in vivo skin cancer screening is presented, combining optical coherence tomography (OCT) and optoacoustic (OA) modalities to provide precise tumor depth determination with a Raman spectroscopic modality capable of detecting the lesion type and, thus, providing diagnostic capability. Both optoacoustic and Raman setups use wide field skin illumination to ensure the compliance with Maximum Permissible Exposure (MPE) requirements. The Raman signal is collected via the OCT scanning lens to maximize the signal-to-noise ratio (SNR) of the measured signal while keeping radiation levels below MPE limits...
January 23, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29315147/nonmelanoma-skin-cancer-risk-in-patients-with-inflammatory-bowel-disease-undergoing-thiopurine-therapy-a-systematic-review-of-the-literature
#4
Joshua W Hagen, Melissa A Pugliano-Mauro
BACKGROUND: Azathioprine and 6-mercaptopurine (thiopurines) are common adjunct treatments for inflammatory bowel disease (IBD). Although thiopurine therapy in organ transplant recipients is known to increase nonmelanoma skin cancers (NMSCs), dermatologic literature yields less data regarding NMSC risk of thiopurine use in IBD. OBJECTIVE: The aim of this study was to systematically review current literature on NMSC risk in patients with IBD using thiopurine therapy...
January 8, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29249251/-what-s-new-in-oncodermatology
#5
C Lebbé
This 'What's new in oncodermatology?' addresses the developments in 2017 on the epidemiology and management of skin cancers. We observe a constant increase in carcinomas, risk factors for squamous cell carcinoma, especially in transplant recipients where skin cancer mortality is important. Among epidemiological developments in melanoma are increased mortality despite screening, occupational exposure to UV, second melanoma and higher risk after carcinoma. New classifications that should be considered are AJCC8 for melanoma and carcinoma...
December 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29237168/evaluation-of-the-national-swiss-skin-cancer-screening-campaign-2013-do-we-do-the-right-thing
#6
Ralph-Peter Braun, Karina Ulrich, Robert Hunger, Olivier Gaide, Andreas Arnold, Rastine Merat, Reinhard Dummer, Jürg Hafner, Lars E French, Antonio Cozzio
BACKGROUND: Skin cancer prevention and screening programs are performed in many countries. Their benefit is discussed controversially. OBJECTIVE: Our aim is to evaluate the Skin Cancer Screening Program 2013 in Switzerland by following up screenees upon interventions. METHODS: Quality was assessed by personal follow-up via phone/e-mail of every patient that had been screened during this campaign and histological follow-up of all participants with suspicious skin lesions...
December 14, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29176098/incidence-of-non-melanoma-skin-cancer-in-the-uninsured
#7
Ashley Sturgeon, David Allen Pate, Ravi Patel, Katherine Snodgrass, Michelle Tarbox, Fiona Prabhu, Phillip Watkins
Non-melanoma skin cancer (NMSC) is a common reason for outpatient primary care visits. Uninsured patients may be at a higher risk for NMSC due to lack of access to health care and a possible increased risk of sun exposure due to insecure housing. The true incidence of NMSC in this population is unknown. In order to determine the population's incidence of NMSC we performed a retrospective chart review on all patients (n = 656) seen at the Lubbock Impact Free Clinic from July 1, 2014 through July 30, 2015. This highlighted an increased incidence of NMSC in our uninsured population (1...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/29169295/observed-and-expected-mortality-in-the-german-skin-cancer-screening-pilot-project-screen
#8
Nora Eisemann, Annika Waldmann, Bernd Holleczek, Alexander Katalinic
Objective The main purpose of skin cancer screening is melanoma mortality reduction. Before the implementation of nationwide German skin cancer screening, the pilot project SCREEN was conducted in Schleswig-Holstein in 2003-2004. We aimed to determine whether the pilot project had achieved a mortality reduction. Methods Using an incidence-based approach (patients with both melanoma diagnosis and death in 2003-2008), we compared the observed melanoma mortality of the SCREEN cohort to the melanoma mortality expected without screening in the general population of Saarland...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/29092508/development-of-a-combined-oct-raman-probe-for-the-prospective-in-vivo-clinical-melanoma-skin-cancer-screening
#9
M Mazurenka, L Behrendt, M Meinhardt-Wollweber, U Morgner, B Roth
A combined optical coherence tomography (OCT)-Raman probe was designed and built into a spectral domain OCT head, and its performance was evaluated and compared to the most common Raman probe setups, based on a fiber bundle and confocal free space optics. Due to the use of the full field of view of an OCT scanning lens, the combined probe has a superior performance within maximum permissible exposure limits, compared to the other two probes. Skin Raman spectra, recorded in vivo, further prove the feasibility of the OCT-Raman probe for the future in vivo clinical applications in skin cancer screening...
October 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29063525/evaluation-of-the-national-skin-cancer-campaign-a-swiss-experience-of-euromelanoma
#10
Sven Lieberherr, S Morteza Seyed Jafari, Simone Cazzaniga, Enrica Bianchi, Bettina Schlagenhauff, Gion Tscharner, Jürg Hafner, Carlo Mainetti, Anne-Karine Lapointe, Robert E Hunger
AIMS OF THE STUDY: Skin cancer is a burden to healthcare and patients worldwide. The incidence of skin cancer has been rising during recent decades and this trend is expected to continue in the future. Numerous risk factors have been identified and prevention strategies developed. The Euromelanoma campaign is a pan-European skin cancer prevention programme, targeted to both primary and secondary prevention of malignant melanoma. The current study aimed to evaluate the results of the Swiss skin cancer screening day 2016...
October 24, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29061478/impact-of-dermatology-econsults-on-access-to-care-and-skin-cancer-screening-in-underserved-populations-a-model-for-teledermatology-services-in-community-health-centers
#11
Fludiona Naka, Jun Lu, Anthony Porto, Jose Villagra, Zhao Helen Wu, Daren Anderson
BACKGROUND: The clinical outcome of teledermatology with dermoscopy in large-scale primary care networks remains unclear. OBJECTIVE: We evaluate the impact of implementing a teledermatology consultation program with dermoscopy on a statewide scale, focusing on access to care and skin cancer screening for medically underserved populations. METHODS: Descriptive retrospective cohort study of 2385 dermatology referrals from primary care from June 2014 through November 2015...
October 20, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29059953/an-embedded-system-for-image-segmentation-and-multimodal-registration-in-noninvasive-skin-cancer-screening
#12
Silvana Diaz, Javier E Soto, Fabian Inostroza, Sebastian E Godoy, Miguel Figueroa
We present a heterogeneous architecture for image registration and multimodal segmentation on an embedded system for noninvasive skin cancer screening. The architecture combines Otsu thresholding and the random walker algorithm to perform image segmentation, and features a hardware implementation of the Harris corner detection algorithm to perform region-of-interest detection and image registration. Running on a Xilinx XC7Z020 reconfigurable system-on-a-chip, our prototype computes the initial segmentation of a 400×400-pixel region of interest in the visible spectrum in 12...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28886812/smartphone-based-applications-for-skin-monitoring-and-melanoma-detection
#13
REVIEW
Elizabeth Chao, Chelsea K Meenan, Laura K Ferris
With the advancement of mobile technologies, smartphone applications (apps) have become widely available and gained increasing attention as a novel tool to deliver dermatologic care. This article presents a review of various apps for skin monitoring and melanoma detection and a discussion of current limitations in the field of dermatology. Concerns regarding quality, transparency, and reliability have emerged because there are currently no established quality standards or regulatory oversight of mobile medical apps...
October 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28877950/effects-of-complex-interventions-in-skin-cancer-prevention-and-treatment-protocol-for-a-mixed-method-systematic-review-with-qualitative-comparative-analysis
#14
Karolina Beifus, Eckhard Breitbart, Juliane Köberlein-Neu
INTRODUCTION: Occurring from ultraviolet radiation combined with impairing ozone levels, uncritical sun exposure and use of tanning beds an increasing number of people are affected by different types of skin cancer. But preventive interventions like skin cancer screening are still missing the evidence for effectiveness and therefore are criticised. Fundamental for an appropriate course of action is to approach the defined parameters as measures for effectiveness critically. A prerequisite should be the critical application of used parameter that are defined as measures for effectiveness...
September 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28832980/nationwide-skin-cancer-screening-in-germany-evaluation-of-the-training-program
#15
Markus P Anders, Susanne Fengler, Beate Volkmer, Rüdiger Greinert, Eckhard W Breitbart
BACKGROUND: In July 2008, the German statutory health insurance introduced a nationwide skin cancer screening program. Before the introduction, eligible physicians had to qualify to perform the screening test and counsel their patients on skin cancer screening. To educate physicians, a curriculum and training materials were developed. Since 2015 a revised curriculum and training materials have been used. The purpose of this paper is to provide information about the curriculum and to evaluate the revised training program...
August 18, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28813744/alkaptonuria-a-case-report-with-diagnostic-challenge
#16
Vasantha L Gali, Amy M Kerkvliet, Jacob M Kusmak, Jana K Elwood
Alkaptonuria is a rare autosomal recessive metabolic disorder caused by deficiency of homogentisic acid (HGA) oxidase, the only enzyme capable of catabolizing HGA. Deficiency of this enzyme leads to excess HGA which deposits in the connective tissue. We present a case of a 64-year-old woman who was referred to the dermatology clinic for a full body mole check and skin cancer screening. Clinically she had blue/gray pigmentation of the external ear and sclera. Also she had a domed papule on the left cheek with punctate gray pigmentation which was biopsied...
August 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28768305/patient-perceptions-of-primary-care-based-skin-cancer-screening
#17
Amanda R Shaub, Eleanor T Lewis, Susan M Swetter
No abstract text is available yet for this article.
November 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28758010/skin-cancer-screening-recommendations-for-data-driven-screening-guidelines-and-a-review-of-the-us-preventive-services-task-force-controversy
#18
REVIEW
Mariah M Johnson, Sancy A Leachman, Lisa G Aspinwall, Lee D Cranmer, Clara Curiel-Lewandrowski, Vernon K Sondak, Clara E Stemwedel, Susan M Swetter, John Vetto, Tawnya Bowles, Robert P Dellavalle, Larisa J Geskin, Douglas Grossman, Kenneth F Grossmann, Jason E Hawkes, Joanne M Jeter, Caroline C Kim, John M Kirkwood, Aaron R Mangold, Frank Meyskens, Michael E Ming, Kelly C Nelson, Michael Piepkorn, Brian P Pollack, June K Robinson, Arthur J Sober, Shannon Trotter, Suraj S Venna, Sanjiv Agarwala, Rhoda Alani, Bruce Averbook, Anna Bar, Mirna Becevic, Neil Box, William E Carson, Pamela B Cassidy, Suephy C Chen, Emily Y Chu, Darrel L Ellis, Laura K Ferris, David E Fisher, Kari Kendra, David H Lawson, Philip D Leming, Kim A Margolin, Svetomir Markovic, Mary C Martini, Debbie Miller, Debjani Sahni, William H Sharfman, Jennifer Stein, Alexander J Stratigos, Ahmad Tarhini, Matthew H Taylor, Oliver J Wisco, Michael K Wong
Melanoma is usually apparent on the skin and readily detected by trained medical providers using a routine total body skin examination, yet this malignancy is responsible for the majority of skin cancer-related deaths. Currently, there is no national consensus on skin cancer screening in the USA, but dermatologists and primary care providers are routinely confronted with making the decision about when to recommend total body skin examinations and at what interval. The objectives of this paper are: to propose rational, risk-based, data-driven guidelines commensurate with the US Preventive Services Task Force screening guidelines for other disorders; to compare our proposed guidelines to recommendations made by other national and international organizations; and to review the US Preventive Services Task Force's 2016 Draft Recommendation Statement on skin cancer screening...
March 2017: Melanoma Management
https://www.readbyqxmd.com/read/28752269/opportunities-for-skin-cancer-prevention-education-among-individuals-attending-a-community-skin-cancer-screening-in-a-high-risk-catchment-area
#19
Bridget Grahmann Parsons, Lisa H Gren, Sara E Simonsen, Garrett Harding, Douglas Grossman, Yelena P Wu
Despite the highly preventable nature of skin cancer, it remains the most commonly diagnosed form of cancer in the United States. Recommendations for a complete skin cancer prevention regimen include engaging in photoprotection (e.g., sunscreen use), avoiding skin cancer risk behaviors (e.g., tanning), and receiving total body skin exams from a health care provider. The current study examined reported engagement in these behaviors among participants attending a community skin cancer screening (N = 319) in a high-risk catchment area to assess the need for increased health education on skin cancer prevention...
July 27, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28715582/iris-freckles-a-potential-biomarker-for-chronic-sun-damage
#20
Christoph Schwab, Christoph Mayer, Iris Zalaudek, Regina Riedl, Markus Richtig, Werner Wackernagel, Rainer Hofmann-Wellenhof, Georg Richtig, Gerald Langmann, Lisa Tarmann, Andreas Wedrich, Erika Richtig
Purpose: To investigate the role of sunlight exposure in iris freckles formation. Methods: We prospectively examined volunteers attending a skin cancer screening program conducted by ophthalmologists and dermatologists. Frequency and topographical variability of iris freckles were noted and associated with behavioral and dermatologic characteristics indicating high sun exposure. Results: Six hundred thirty-two participants (n = 360; 57% female) were examined...
May 1, 2017: Investigative Ophthalmology & Visual Science
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