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https://www.readbyqxmd.com/read/28813744/alkaptonuria-a-case-report-with-diagnostic-challenge
#1
Vasantha L Gali, Amy M Kerkvliet, Jacob M Kusmak, Jana K Elwood
Alkaptonuria is a rare autosomal recessive metabolic disorder caused by deficiency of homogentisic acid (HGA) oxidase, the only enzyme capable of catabolizing HGA. Deficiency of this enzyme leads to excess HGA which deposits in the connective tissue. We present a case of a 64-year-old woman who was referred to the dermatology clinic for a full body mole check and skin cancer screening. Clinically she had blue/gray pigmentation of the external ear and sclera. Also she had a domed papule on the left cheek with punctate gray pigmentation which was biopsied...
August 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28768305/patient-perceptions-of-primary-care-based-skin-cancer-screening
#2
Amanda R Shaub, Eleanor T Lewis, Susan M Swetter
No abstract text is available yet for this article.
August 2, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28758010/skin-cancer-screening-recommendations-for-data-driven-screening-guidelines-and-a-review-of-the-us-preventive-services-task-force-controversy
#3
REVIEW
Mariah M Johnson, Sancy A Leachman, Lisa G Aspinwall, Lee D Cranmer, Clara Curiel-Lewandrowski, Vernon K Sondak, Clara E Stemwedel, Susan M Swetter, John Vetto, Tawnya Bowles, Robert P Dellavalle, Larisa J Geskin, Douglas Grossman, Kenneth F Grossmann, Jason E Hawkes, Joanne M Jeter, Caroline C Kim, John M Kirkwood, Aaron R Mangold, Frank Meyskens, Michael E Ming, Kelly C Nelson, Michael Piepkorn, Brian P Pollack, June K Robinson, Arthur J Sober, Shannon Trotter, Suraj S Venna, Sanjiv Agarwala, Rhoda Alani, Bruce Averbook, Anna Bar, Mirna Becevic, Neil Box, William E Carson, Pamela B Cassidy, Suephy C Chen, Emily Y Chu, Darrel L Ellis, Laura K Ferris, David E Fisher, Kari Kendra, David H Lawson, Philip D Leming, Kim A Margolin, Svetomir Markovic, Mary C Martini, Debbie Miller, Debjani Sahni, William H Sharfman, Jennifer Stein, Alexander J Stratigos, Ahmad Tarhini, Matthew H Taylor, Oliver J Wisco, Michael K Wong
Melanoma is usually apparent on the skin and readily detected by trained medical providers using a routine total body skin examination, yet this malignancy is responsible for the majority of skin cancer-related deaths. Currently, there is no national consensus on skin cancer screening in the USA, but dermatologists and primary care providers are routinely confronted with making the decision about when to recommend total body skin examinations and at what interval. The objectives of this paper are: to propose rational, risk-based, data-driven guidelines commensurate with the US Preventive Services Task Force screening guidelines for other disorders; to compare our proposed guidelines to recommendations made by other national and international organizations; and to review the US Preventive Services Task Force's 2016 Draft Recommendation Statement on skin cancer screening...
March 2017: Melanoma Management
https://www.readbyqxmd.com/read/28752269/opportunities-for-skin-cancer-prevention-education-among-individuals-attending-a-community-skin-cancer-screening-in-a-high-risk-catchment-area
#4
Bridget Grahmann Parsons, Lisa H Gren, Sara E Simonsen, Garrett Harding, Douglas Grossman, Yelena P Wu
Despite the highly preventable nature of skin cancer, it remains the most commonly diagnosed form of cancer in the United States. Recommendations for a complete skin cancer prevention regimen include engaging in photoprotection (e.g., sunscreen use), avoiding skin cancer risk behaviors (e.g., tanning), and receiving total body skin exams from a health care provider. The current study examined reported engagement in these behaviors among participants attending a community skin cancer screening (N = 319) in a high-risk catchment area to assess the need for increased health education on skin cancer prevention...
July 27, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28715582/iris-freckles-a-potential-biomarker-for-chronic-sun-damage
#5
Christoph Schwab, Christoph Mayer, Iris Zalaudek, Regina Riedl, Markus Richtig, Werner Wackernagel, Rainer Hofmann-Wellenhof, Georg Richtig, Gerald Langmann, Lisa Tarmann, Andreas Wedrich, Erika Richtig
Purpose: To investigate the role of sunlight exposure in iris freckles formation. Methods: We prospectively examined volunteers attending a skin cancer screening program conducted by ophthalmologists and dermatologists. Frequency and topographical variability of iris freckles were noted and associated with behavioral and dermatologic characteristics indicating high sun exposure. Results: Six hundred thirty-two participants (n = 360; 57% female) were examined...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28692584/association-between-risk-factors-and-detection-of-cutaneous-melanoma-in-the-setting-of-a-population-based-skin-cancer-screening
#6
Joachim Hübner, Annika Waldmann, Nora Eisemann, Maria Noftz, Alan C Geller, Martin A Weinstock, Beate Volkmer, Rüdiger Greinert, Eckhard W Breitbart, Alexander Katalinic
Early detection is considered to improve the prognosis of cutaneous melanoma. The value of population-based screening for melanoma, however, is still controversial. The aim of this study was to evaluate the predictive power of established risk factors in the setting of a population-based screening and to provide empirical evidence for potential risk stratifications. We reanalyzed data (including age, sex, risk factors, and screening results) of 354 635 participants in the Skin Cancer Research to provide Evidence for Effectiveness of Screening in Northern Germany project conducted in the German state of Schleswig-Holstein (2003-2004)...
July 7, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28681396/association-of-atopy-and-tentative-diagnosis-of-skin-cancer-results-from-occupational-skin-cancer-screenings
#7
I Schäfer, P Mohr, N Zander, R Fölster-Holst, M Augustin
BACKGROUND: The relationship between atopic conditions and carcinoma of the skin has been described inconsistently. Population-based data providing information on atopic diseases as well as on skin-cancer are sparse. OBJECTIVE: To determine the correlation between atopy and prevalence of precanceroses, nonmelanoma skin-cancer and malignant melanoma (MM), while taking into account known risk factors for skin cancer. METHODS: Data from occupational skin cancer screenings were analysed in a cross-sectional study...
July 6, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28679298/prevalence-of-cutaneous-viral-infections-in-incident-cutaneous-squamous-cell-carcinoma-detected-among-chronic-lymphocytic-leukemia-and-hematopoietic-stem-cell-transplant-patients
#8
Shalaka S Hampras, Frederick L Locke, Julio C Chavez, Nishit S Patel, Anna R Giuliano, Kyle Miller, Tarik Gheit, Massimo Tommasino, Dana E Rollison
The role of cutaneous viral infections in the development of non-melanoma skin cancer (NMSC), including cutaneous squamous cell carcinoma (SCC), among chronic lymphocytic leukemia (CLL) and blood and marrow transplant (BMT) patients is not established. CLL (n = 977) and BMT (n = 3587) patients treated at the Moffitt Cancer Center were included in a retrospective cohort study. Human papillomavirus (HPV) and human polyomavirus (HPyV) DNA were examined in a subset of incident SCC tumors. Five-year cumulative incidence of NMSC was 1...
July 6, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28663910/raman-active-components-of-skin-cancer
#9
Xu Feng, Austin J Moy, Hieu T M Nguyen, Jason Zhang, Matthew C Fox, Katherine R Sebastian, Jason S Reichenberg, Mia K Markey, James W Tunnell
Raman spectroscopy (RS) has shown great potential in noninvasive cancer screening. Statistically based algorithms, such as principal component analysis, are commonly employed to provide tissue classification; however, they are difficult to relate to the chemical and morphological basis of the spectroscopic features and underlying disease. As a result, we propose the first Raman biophysical model applied to in vivo skin cancer screening data. We expand upon previous models by utilizing in situ skin constituents as the building blocks, and validate the model using previous clinical screening data collected from a Raman optical fiber probe...
June 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28632800/total-body-photography-in-skin-cancer-screening-the-clinical-utility-of-standardized-imaging
#10
Alexandra Rosenberg, Jon H Meyerle
Early detection of skin cancer is essential to reducing morbidity and mortality from both melanoma and nonmelanoma skin cancers. Total-body skin examinations (TBSEs) may improve early detection of malignant melanomas (MMs) but are controversial due to the poor quality of data available to establish a mortality benefit from skin cancer screening. Total-body photography (TBP) promises to provide a way forward by lowering the costs of dermatologic screening while simultaneously leveraging technology to increase patient access to dermatologic care...
May 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28593242/primary-care-based-skin-cancer-screening-in-a-veterans-affairs-health-care-system
#11
Susan M Swetter, Julia Chang, Amanda R Shaub, Martin A Weinstock, Eleanor T Lewis, Steven M Asch
Importance: Skin cancer screening may improve melanoma outcomes and keratinocyte carcinoma morbidity, but little is known about the feasibility of skin cancer training and clinical skin examination (CSE) by primary care practitioners (PCPs) in large health care systems. Objective: To assess the association of skin cancer training and screening by PCPs with dermatology referral patterns and rates of skin biopsies. Design, Setting, and Participants: In this pilot interventional study performed at the Veterans Affairs Palo Alto Health Care System, patients 35 years or older scheduled for an annual health habits screen in the PCP general medicine clinics were studied...
August 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28543620/squamous-cell-carcinoma-in-the-afro-caribbean-community-an-11-year-retrospective-study
#12
Nadège Cordel, Lucie Bonnecarrère, Benoit Tressières
BACKGROUND: Squamous cell carcinoma (SCC) is considered the most frequent skin cancer in black people. Its incidence is not known in the Afro-Caribbean population. OBJECTIVE: To assess the incidence of SCC in Guadeloupe, the largest island of the Lesser Antilles (405 000 inhabitants, mostly black people of African and European descent). The second objective was to characterize clinical and histological patterns of SCC occurring in the Afro-Caribbean community. METHODS: This retrospective study was conducted over an 11-year period (2000-2010)...
May 22, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28515993/triage-amalgamated-dermoscopic-algorithm-tada-for-skin-cancer-screening
#13
Tova Rogers, Maria Marino, Stephen W Dusza, Shirin Bajaj, Michael A Marchetti, Ashfaq Marghoob
IMPORTANCE: Dermoscopic triage algorithms have been shown to improve beginners' abilities for identifying pigmented skin lesions requiring biopsy. OBJECTIVE: To estimate the diagnostic accuracy of the Triage Amalgamated Dermoscopic Algorithm (TADA) for pigmented and nonpigmented skin cancers. Secondarily, to compare TADAs performance to those of existing triage algorithms for the identification of pigmented skin cancers. DESIGN: Cross-sectional, observational, reader study that took place at a beginner and intermediate level dermoscopy course...
April 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/28507733/assessment-of-postgraduate-skin-lesion-education-among-iowa-family-physicians
#14
Nicholas J Goetsch, James D Hoehns, John E Sutherland, Matthew E Ulven, Olayinka O Shiyanbola, Monica K Rauch
BACKGROUND: Family medicine physicians play a pivotal role in the prevention and early detection of skin cancer. Our objective was to evaluate how family physicians believe their postgraduate training in skin cancer screening and prevention has prepared them for independent practice and to assess the need for enhanced skin lesion teaching in a family medicine residency setting. METHODS: A descriptive, cross-sectional survey investigating provider demographics, confidence in providing dermatological care, residency training, current medical practice, and skin cancer prevention beliefs was mailed to all family medicine physicians in the state of Iowa as listed in the Iowa Academy of Family Physicians annual directory in 2006 (N = 1069)...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28488240/erratum-to-increasing-frequency-of-seborrheic-keratosis-diagnoses-as-a-favorable-consequence-of-teledermatology-based-skin-cancer-screening-a-cross-sectional-study-of-34-553-patients
#15
David Moreno-Ramírez, Jesús Raya-Maldonado, Macarena Morales-Conde, Teresa Ojeda-Vila, Francisco J Martín-Gutiérrez, Andrés Ruíz-de-Casas, Almudena Fernández-Orland, Juan M Herrerías-Esteban, Lara Ferrándiz
No abstract text is available yet for this article.
May 9, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28405739/dermatological-comorbidity-in-psoriasis-results-from-a-large-scale-cohort-of-employees
#16
N Zander, I Schäfer, M Radtke, A Jacobi, H Heigel, M Augustin
The field of dermatological comorbidity in psoriasis is only passively explored with contradictory results. Objective of this study was to further investigate the complex field of psoriasis and associated skin diseases by identifying skin comorbidity patterns in an extensive cohort of employees in Germany. Retrospective analysis of data deriving from occupational skin cancer screenings was conducted. From 2001 to 2014 German employees between 16 and 70 years from different branches underwent single whole-body screenings by trained dermatologists in their companies...
July 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28397109/increasing-frequency-of-seborrheic-keratosis-diagnoses-as-a-favorable-consequence-of-teledermatology-based-skin-cancer-screening-a-cross-sectional-study-of-34-553-patients
#17
David Moreno-Ramírez, Jesús Raya-Maldonado, Macarena Morales-Conde, Teresa Ojeda-Vila, Francisco J Martín-Gutiérrez, Andrés Ruíz-de-Casas, Almudena Fernández-Orland, Herrerías-Esteban Jm, Lara Ferrándiz
BACKGROUND: Screening of skin cancer by teledermatology (TD) has improved the early detection of skin cancer by enhancing access to skin cancer clinics. OBJECTIVE: We sought to analyze how TD-based skin cancer screening has changed the frequency of consultations for benign lesions. PATIENTS AND METHODS: A cross-sectional study including teleconsultations received during a 7-year period was conducted to analyze and compare the trendlines of each lesion type over the study period...
April 10, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28353004/the-effectiveness-of-a-population-based-skin-cancer-screening-program-evidence-from-germany
#18
Micha Kaiser, Jörg Schiller, Christopher Schreckenberger
In this paper, we analyze how a nationwide population-based skin cancer screening program (SCS) implemented in Germany in 2008 has impacted the number of hospital discharges following malignant skin neoplasm diagnosis and the malignant melanoma mortality rate per 100,000 inhabitants. Our panel data, drawn from the Eurostat database, cover subregions in 22 European countries, measured at the lowest nomenclature of territorial units for statistics (NUTS) level for 2000-2013. Applying fixed effects methods, we find a significantly positive and robust effect of the German SCS on the number of patients diagnosed with malignant skin neoplasm...
March 28, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28329558/integrating-the-integrated-skin-exam-film-into-medical-education
#19
Seth Lofgreen, Michael Lehrer, Paige Bennett, Amit Garg, Cory A Dunnick
AbstractBackgroundThe mortality rate for melanoma continues to rise and the greatest improvement in melanoma survival is attributable to early detection with skin cancer screening exams. However, physicians feel that limited training in the examination of skin and limited clinical time both serve as barriers to adequately assess high-risk lesions.ObjectiveTo test the use of The Integrated Skin Exam film as an instructional tool to teach the examination of skin in a live classroom setting, outside of the purview of the original formal study...
November 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28272243/mobile-teledermatology-for-skin-cancer-screening-a-diagnostic-accuracy-study
#20
Stefan Markun, Nathalie Scherz, Thomas Rosemann, Ryan Tandjung, Ralph P Braun
Skin cancer screening has undoubted potential to reduce cancer-specific morbidity and mortality. Total-body exams remain the prevailing concept of skin cancer screening even if effectiveness and value of this method are controversial. Meanwhile, store and forward teledermatology was shown to be a reliable instrument for several diagnostic purposes mostly in specialized dermatology settings. The objective of this study was to evaluate most convenient mobile teledermatology interventions as instruments for skin cancer screening in a representative population...
March 2017: Medicine (Baltimore)
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