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Bone specific alkaline phosphatase

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https://www.readbyqxmd.com/read/29330573/tocotrienol-supplementation-suppressed-bone-resorption-and-oxidative-stress-in-postmenopausal-osteopenic-women-a-12-week-randomized-double-blinded-placebo-controlled-trial
#1
C-L Shen, S Yang, M D Tomison, A W Romero, C K Felton, H Mo
Tocotrienols have shown bone-protective effect in animals. This study showed that a 12-week tocotrienol supplementation decreased concentrations of bone resorption biomarker and bone remodeling regulators via suppressing oxidative stress in postmenopausal osteopenic women. INTRODUCTION: Tocotrienols (TT) have been shown to benefit bone health in ovariectomized animals, a model of postmenopausal women. The purpose of this study was to evaluate the effect of 12-week TT supplementation on bone markers (serum bone-specific alkaline phosphatase (BALP), urine N-terminal telopeptide (NTX), serum soluble receptor activator of nuclear factor-kappaB ligand (sRANKL), and serum osteoprotegerin (OPG)), urine calcium, and an oxidative stress biomarker (8-hydroxy-2'-deoxyguanosine (8-OHdG)) in postmenopausal women with osteopenia...
January 12, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29323151/downregulation-of-heat-shock-protein-70-impairs-osteogenic-and-chondrogenic-differentiation-in-human-mesenchymal-stem-cells
#2
Chenghai Li, Kristifor Sunderic, Steven B Nicoll, Sihong Wang
Human mesenchymal stem cells (hMSCs) show promise for bone and cartilage regeneration. Our previous studies demonstrated that hMSCs with periodic mild heating had enhanced osteogenic and chondrogenic differentiation with significantly upregulated heat shock protein 70 (HSP70). However, the role of HSP70 in adult tissue regeneration is not well studied. Here, we revealed an essential regulatory mechanism of HSP70 in osteogenesis and chondrogenesis using adult hMSCs stably transfected with specific shRNAs to knockdown HSP70...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29318649/treatment-related-changes-in-bone-turnover-and-fracture-risk-reduction-in-clinical-trials-of-anti-resorptive-drugs-a-meta-regression
#3
Douglas C Bauer, Dennis M Black, Mary L Bouxsein, Li-Yung Lui, Jane A Cauley, Anne E de Papp, Andreas Grauer, Sundeep Khosla, Charles E McCulloch, Richard Eastell
Few pooled analyses of antiresorptive (AR) treatment trials relate short-term changes in bone turnover markers (BTMs) to subsequent fracture reduction. Such information would be useful to assess new ARs or novel dosing regimens. In the Foundation for the National Institutes of Health (FNIH) Bone Quality project, we analyzed individual-level data from 28,000 participants enrolled in 11 bisphosphonate (BP) and three selective estrogen receptor modulator (SERM) placebo-controlled fracture endpoint trials. Using BTM results for two bone formation markers (bone-specific alkaline phosphatase [bone ALP] and pro-collagen I N-propeptide [PINP]) and two bone resorption markers (N-terminal and C-terminal telopeptide of type I collagen) and incident fracture outcome data, we performed a meta-regression relating the mean net effect of treatment on change in bone turnover (active minus placebo % difference after 3 to 12 months) to the log of study-wide fracture risk reduction, and used linear regression to plot the best fitting line...
January 10, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29305674/comparable-osteogenic-capacity-of-mesenchymal-stem-or-stromal-cells-derived-from-human-amnion-membrane-and-bone-marrow
#4
Mehran Ghasemzadeh, Ehteramolsadat Hosseini, Mohammadhossein Ahmadi, Maedeh Kamalizad, Naser Amirizadeh
So far, substantial attentions have been attracted to the application of mesenchymal stem or stromal cells (MSCs) in different therapeutic approaches. Although human bone marrow is commonly considered as a major source for MSCs, having an invasive collection method, ethical consideration and donor availability create a challenge for scientists, leading them to explore better alternative sources for MSCs. The study presented here aimed to characterize and compare osteogenic capacity of MSCs obtained from the amnion membrane (AM) with those originated from BM...
January 5, 2018: Cytotechnology
https://www.readbyqxmd.com/read/29288400/anti-inflammatory-and-antiresorptive-effects-of-calendula-officinalis-on-inflammatory-bone-loss-in-rats
#5
Joanna Trycia M Alexandre, Luzia Hermínia Teixeira Sousa, Mario Roberto Pontes Lisboa, Flávia A C Furlaneto, Danielle Rocha do Val, Mirna Marques, Hellíada C Vasconcelos, Iracema Matos de Melo, Renata Leitão, Gerly Anne Castro Brito, Paula Goes
OBJECTIVE: The aim of this work was to evaluate the anti-inflammatory and antiresorptive effects of Calendula officinalis (CLO) on alveolar bone loss (ABL) in rats. MATERIAL AND METHODS: Male Wistar rats were subjected to ABL by ligature with nylon thread around the second upper left molar. The contralateral hemimaxillae were used as control. Rats received saline solution (SAL) or CLO (10, 30, or 90 mg/kg) 30 min before ligature and daily until the 11th day. The maxillae were removed and prepared for macroscopic, radiographic, micro-tomographic, histopathologic, histometric analysis, and immunohistochemical localization of receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG)...
December 29, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29281939/bone-specific-alkaline-phosphatase-a-potential-biomarker-for-skeletal-growth-assessment
#6
Tulika Tripathi, Prateek Gupta, Jitender Sharma, Priyank Rai, Vinod Kumar Gupta, Navneet Singh
OBJECTIVE: The present study was aimed to assess levels of serum Bone-specific alkaline phosphatase (BALP) and serum Insulin-like growth factor-1 (IGF-1) and comparing with cervical vertebral maturation index (CVMI) stages. DESIGN: Cross-sectional study. SETTING: Maulana Azad Institute of Dental Sciences, New Delhi, India. PARTICIPANTS: 150 subjects (75 males and 75 females) in the age group of 8-20 years. METHODS: Subjects were divided into six CVMI stages...
December 27, 2017: Journal of Orthodontics
https://www.readbyqxmd.com/read/29274103/osteogenic-differentiation-of-human-adipose-derived-stem-cells-on-chemically-crosslinked-carbon-nanomaterial-coatings
#7
Sunny C Patel, Owais Alam, Balaji Sitharaman
Carbon nanomaterial coatings have been widely investigated for many biomedical applications including bone tissue engineering. Current methods to fabricate carbon nanomaterial coatings are limited by specific substrate requirements and the lack of strong bonds between the nanomaterials. Furthermore, few studies compare the effect of carbon nanoparticle architecture on stem cell differentiation and mineralization for osteogenic differentiation. Herein, we report a study comparing chemically crosslinked carbon nanotubes (of various diameters), graphene nanoplatelets, and graphene nanoribbons coatings for adipose derived stem cell differentiation towards an osteogenic lineage...
December 23, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29260292/vitamin-d-supplementation-and-bone-turnover-in-advanced-heart-failure-the-evita-trial
#8
A Zittermann, J B Ernst, S Prokop, U Fuchs, J Dreier, J Kuhn, H K Berthold, S Pilz, I Gouni-Berthold, J F Gummert
Low vitamin D status is common in patients with heart failure and may influence bone health. A daily vitamin D dose of 4000 IU (moderately high dose) for 3 years had however no effect on parameters of bone metabolism, even in patients with very low vitamin D status. INTRODUCTION: Low vitamin D status is common in patients with heart failure (HF) and has been related to disturbed bone turnover. The present study investigated the effect of a daily vitamin D3 dose of 4000 IU on bone turnover markers (BTMs) in patients with advanced HF and 25-hydroxyvitamin D (25OHD) concentrations < 75 nmol/L...
December 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29250118/il-1-tnf-%C3%AE-inflammatory-and-anti-inflammatory-synchronization-affects-gingival-stem-progenitor-cells-regenerative-attributes
#9
Fan Zhang, Misi Si, Huiming Wang, Mohamed K Mekhemar, Christof E Dörfer, Karim M Fawzy El-Sayed
Cytokines play major roles in tissue destruction/repair. The present study investigates proliferative and osteogenic differentiation potentials of gingival mesenchymal stem/progenitor cells (G-MSCs), influenced by IL-1/TNF-α inflammatory/anti-inflammatory conditions. Human G-MSCs were isolated, characterized, and cultured in basic medium (control group, M1), in basic medium with IL-1β, TNF-α, and IFN-γ (inflammatory group, M2) and with IL-1ra/TNF-αi added to M2 (anti-inflammatory group, M3). MTT tests at days 1, 3, and 7 and CFU assay at day 12 were conducted...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29246529/teriparatide-treatment-in-an-adult-patient-with-hypophosphatasia-exposed-to-bisphosphonate-and-revealed-by-bilateral-atypical-fractures
#10
Morgane Righetti, Jean Wach, Romain Desmarchelier, Fabienne Coury
Atypical femoral fractures are defined as atraumatic fractures located in the subtrochanteric region or femoral shaft. They have been mainly reported in patients taking bisphosphonates.We report the case of a 67-year-old female with osteoporosis treated by alendronate during ten years.Radiographies showed atypical femoral fractures. Serum levels of total and bone-specific alkaline phosphatase were low. In order to accelerate bone healing, teriparatide was introduced. After one year of teriparatide treatment, pain and functional difficulty have decreased, and alkaline phosphatase levels were normalised...
December 12, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29242275/igfbp7-regulates-the-osteogenic-differentiation-of-bone-marrow-derived-mesenchymal-stem-cells-via-wnt-%C3%AE-catenin-signaling-pathway
#11
Wei Zhang, Erman Chen, Mo Chen, Chenyi Ye, Yiying Qi, Qianhai Ding, Hang Li, Deting Xue, Xiang Gao, Zhijun Pan
Insulin-like growth factor-binding protein 7 (IGFBP7), a low-affinity IGF binder, may play an important role in bone metabolism. However, its function in osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (BMSCs) remains unclear. Therefore, we investigated its effects on osteogenic differentiation. Overexpression of IGFBP7 enhanced the expression of osteo-specific genes and proteins, and IGFBP7 knockdown decreased osteogenesis-specific markers. More mineral deposits and higher alkaline phosphatase activity were observed after the up-regulation of IGFBP7 Moreover, β-catenin levels were up-regulated by the overexpression of IGFBP7 or the addition of extracellular IGFBP7 protein and were reduced by the depletion of IGFBP7 The increase in osteogenic differentiation due to the overexpression of IGFBP7 was partially decreased by specific Wnt/β-catenin signaling inhibitors...
December 14, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29238079/dorsal-root-ganglion-neurons-regulate-the-transcriptional-and-translational-programs-of-osteoblast-differentiation-in-a-microfluidic-platform
#12
Diana Isabel Silva, Bruno Paiva Dos Santos, Jacques Leng, Hugo Oliveira, Joëlle Amédée
Innervation by the sensory nervous system plays a key role in skeletal development and in orchestration of bone remodeling and regeneration. However, it is unclear how and in which bone cells can sensory nerves act to control these processes. Here, we show a microfluidic coculture system comprising dorsal root ganglion (DRG) neurons and mesenchymal stem cells (MSCs) that more faithfully represents the in vivo scenario of bone sensory innervation. We report that DRG neurons promote the osteogenic differentiation capacity of MSCs, by mediating the increase of alkaline phosphatase activity and the upregulation of osteoblast-specific genes...
December 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29229438/pulsed-electromagnetic-fields-pemf-attenuate-changes-in-vertebral-bone-mass-architecture-and-strength-in-ovariectomized-mice
#13
Tao Lei, Zhuowen Liang, Feijiang Li, Chi Tang, Kangning Xie, Pan Wang, Xu Dong, Shuai Shan, Maogang Jiang, Qiaoling Xu, Erping Luo, Guanghao Shen
Pulsed electromagnetic fields (PEMF) has been investigated as a noninvasive alternative method to prevent bone loss for postmenopausal osteoporosis (OP), and the bone tissue involved in these studies are usually long bones such as femur and tibia in OP patients or rat models. However, few studies have investigated the effects of PEMF on the vertebral bone in mice with OP. This study aimed to investigate whether PEMF preserve lumbar vertebral bone mass, microarchitecture and strength in ovariectomized (OVX) mouse model of OP and its associated mechanisms...
December 8, 2017: Bone
https://www.readbyqxmd.com/read/29228681/cyclophosphamide-causes-osteoporosis-in-c57bl-6-male-mice-suppressive-effects-of-cyclophosphamide-on-osteoblastogenesis-and-osteoclastogenesis
#14
Dongfeng Zhao, Chenglong Wang, Yongjian Zhao, Bing Shu, Youji Jia, Shufen Liu, Hongshen Wang, Junli Chang, Weiwei Dai, Sheng Lu, Qi Shi, Yanping Yang, Yan Zhang, Yongjun Wang
The clinical evidence indicated that cyclophosphamide (CPD), one of the chemotherapy drugs, caused severe deteriorations in bones of cancer patients. However, the exact mechanisms by which CPD exerts effects on bone remodeling is not yet fully elucidated. Therefore, this study was performed to investigate the role and potential mechanism of CPD in osteoblastogenesis and osteoclastogenesis. Here it was found that CPD treatment (100mg/kg/day) for 7 days led to osteoporosis phenotype in male mice. CPD inhibited osteoblastogenesis as shown by decreasing the number and differentiation of bone mesenchymal stem cells (MSCs) and reducing the formation and activity of osteoblasts...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29218094/mir-351-negatively-regulates-osteoblast-differentiation-of-mscs-induced-by-cholesten-3-one-through-targeting-vdr
#15
Qiuke Hou, Yongquan Huang, Yiwen Luo, Bin Wang, Yamei Liu, Rudong Deng, Saixia Zhang, Fengbin Liu, Dongfeng Chen
Our previous reports indicated that (+)-cholesten-3-one induces osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs) by activating vitamin D receptor (VDR). However, whether and how miRNAs modulate osteogenic differentiation induced by (+)-cholesten-3-one have not been explored. In this study, miRNA array profiling and further validation by quantitative real-time PCR revealed that miR-351 was downregulated during (+)-cholesten-3-one-induced osteogenic differentiation of MSCs. Overexpression of miR-351 by miR-351 precursor transfection markedly inhibited the expression of osteoblast-specific genes, such as alkaline phosphatase (ALP), collagen type II, osteopontin (OPN), and runt-related transcription factor 2 (RUNX2), which consequently decreased a number of calcium mineralized nodules...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29216631/effect-of-cinacalcet-combined-with-calcitriol-on-the-clinical-outcome-and-bone-metabolism-in-patients-on-hemodialysis-with-severe-secondary-hyperparathyroidism
#16
Fang Yuan, Xing Chen, Chang Wang, Zheng Li, Hong Liu
OBJECTIVE: To observe the clinical outcome and the effect of bone metabolism of cinacalcet combined with calcitriol in maintenance hemodialysis (MHD) patients with severe secondary hyperparathyroidism (SHPT). METHODS: Thirty MHD patients with SHPT were enrolled into the study. All patients were given cinacalcet 25-75 mg and 0.5 μg calcitriol daily. Serum Ca, P, intact parathyroid hormone (iPTH), and bone metabolic markers were measured. The clinical symptoms and their changes were investigated...
December 7, 2017: Blood Purification
https://www.readbyqxmd.com/read/29215447/cross-sectional-study-of-four-serological-bone-turnover-markers-for-the-risk-assessment-of-medication-related-osteonecrosis-of-the-jaw
#17
Andre Peisker, Gregor F Raschke, Mina D Fahmy, Arndt Guentsch, Korosh Roshanghias, Kai C König, Stefan Schultze-Mosgau
BACKGROUND: Despite the benefits related to the use of bisphosphonates and denosumab, medication-related osteonecrosis of the jaw (MRONJ) is a serious complication. The purpose of this study was to investigate the utility of 4 biochemical markers including serum c-terminal telopeptide cross-link of type I collagen (s-CTX), serum osteocalcin (s-OC), serum parathormon (s-PTH), and serum bone-specific alkaline phosphatase (s-BAP) as useful clinical tools to help assess the risk for MRONJ prior to invasive oral surgery...
December 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29208033/evaluating-the-oxysterol-combination-of-22-s-hydroxycholesterol-and-20-s-hydroxycholesterol-in-periodontal-regeneration-using-periodontal-ligament-stem-cells-and-alveolar-bone-healing-models
#18
Jin-Sun Lee, EunJi Kim, Seonggu Han, Kyung Lhi Kang, Jung Sun Heo
BACKGROUND: Oxysterols, oxygenated by-products of cholesterol biosynthesis, play roles in various physiological and pathological systems. However, the effects of oxysterols on periodontal regeneration are unknown. This study investigated the effects of the specific oxysterol combination of 22(S)-hydroxycholesterol and 20(S)-hydroxycholesterol (SS) on the regeneration of periodontal tissues using in-vitro periodontal ligament stem cells (PDLSCs) and in-vivo models of alveolar bone defect...
December 6, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29204337/effects-on-bone-resorption-markers-of-continuing-pamidronate-or-switching-to-zoledronic-acid-in-patients-with-high-risk-bone-metastases-from-breast-cancer
#19
J F Hilton, M Clemons, G Pond, H Zhao, S Mazzarello, L Vandermeer, C L Addison
Background: Switching patients who remain at high risk of skeletal related events (SREs) despite pamidronate to the more potent bisphosphonate zoledronate, may be an effective treatment strategy. As part of a previously reported clinic study in this setting, we evaluated whether biomarkers for bone resorption, such as Bone-Specific Alkaline Phosphatase (BSAP), bone sialoprotein (BSP), and N-terminal telopeptide (NTX) correlated with subsequent SRE risk. Methods: Breast cancer patients who remained at high risk of SREs despite at least 3 months of q...
March 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29202447/bone-forming-peptide-3-induces-osteogenic-differentiation-of-bone-marrow-stromal-cells-via-regulation-of-the-erk1-2-and-smad1-5-8-pathways
#20
Jun Sik Lee, Mi Eun Kim, Jong Keun Seon, Ju Yeon Kang, Taek Rim Yoon, Yong-Duk Park, Hyung Keun Kim
A bone-remodeling imbalance induced by increased bone resorption and osteoclast formation causes skeletal diseases such as osteoporosis. Induction of osteogenic differentiation of bone marrow stromal cells (BMSCs) leads to bone regeneration. Many researchers have tried to develop new adjuvants as specific stimulators of bone regeneration for therapeutic use in patients with bone resorption. We tried to develop a new adjuvant that has stronger osteogenic differentiation-promoting activity than bone morphogenetic proteins (BMPs)...
November 22, 2017: Stem Cell Research
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