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https://www.readbyqxmd.com/read/29327147/post-operative-catheterization-interventions-at-the-site-of-surgery-an-application-of-the-crisp-scoring-system
#1
Katie Mowers, Toby Rockefeller, David Balzer, Ramzi Nicolas, Shabana Shahanavaz
Catheter-based interventions in the early post-operative period are performed with caution due to concerns for increased procedural risk, particularly across fresh suture lines. The recently published CRISP scoring system provides prospective risk stratification based on pre-procedural criterion. In an effort to refine the assessment of risk in patients undergoing post-operative catheter-based interventions, the predicted risk of an adverse event based on CRISP scores was compared to actual adverse event rates...
January 12, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29323115/wet-dry-cycles-enable-the-parallel-origin-of-canonical-and-non-canonical-nucleosides-by-continuous-synthesis
#2
Sidney Becker, Christina Schneider, Hidenori Okamura, Antony Crisp, Tynchtyk Amatov, Milan Dejmek, Thomas Carell
The molecules of life were created by a continuous physicochemical process on an early Earth. In this hadean environment, chemical transformations were driven by fluctuations of the naturally given physical parameters established for example by wet-dry cycles. These conditions might have allowed for the formation of (self)-replicating RNA as the fundamental biopolymer during chemical evolution. The question of how a complex multistep chemical synthesis of RNA building blocks was possible in such an environment remains unanswered...
January 11, 2018: Nature Communications
https://www.readbyqxmd.com/read/29322607/stenting-of-the-inter-atrial-septum-in-infants-and-small-children-indications-techniques-and-outcomes
#3
Gur Mainzer, Sebastian Goreczny, Gareth J Morgan, Shakeel Qureshi, Thomas Krasemann, Pawel Dryzek, Jadwiga A Moll, Tomasz Moszura, Eric Rosenthal
OBJECTIVES: To evaluate the procedural success and outcome of inter-atrial stenting. BACKGROUND: Inter-atrial stenting has been shown to be an effective way to maintain inter-atrial blood flow, however it is considered a high risk procedure, usually performed urgently in patients with significant hemodynamic compromise. METHODS: Between September 2004 and August 2016, inter-atrial stenting was attempted in 29 children. Procedural, clinical, and follow-up data were collected retrospectively...
January 11, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29322076/a-spline-based-regression-parameter-set-for-creating-customized-dartel-mri-brain-templates-from-infancy-to-old-age
#4
Marko Wilke
This dataset contains the regression parameters derived by analyzing segmented brain MRI images (gray matter and white matter) from a large population of healthy subjects, using a multivariate adaptive regression splines approach. A total of 1919 MRI datasets ranging in age from 1-75 years from four publicly available datasets (NIH, C-MIND, fCONN, and IXI) were segmented using the CAT12 segmentation framework, writing out gray matter and white matter images normalized using an affine-only spatial normalization approach...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29319890/two-novel-unstable-hemoglobin-variants-due-to-in-frame-deletions-of-key-amino-acids-in-the-%C3%AE-globin-chain
#5
Karen Gabriela Scheps, Marcia Anahí Hasenahuer, Gustavo Parisi, Héctor M Targovnik, Eliana García, Ernesto Samuel Veber, Renée Crisp, Graciela Elena, Viviana Varela, María Silvina Fornasari
Hemoglobinopathies are the most common autosomal recessive disorders and are mostly inherited in a recessive manner. However, certain mutations can affect the globin chain stability, leading to dominant forms of thalassemia. The aim of this work was the molecular and structural characterization of two heterozygous in-frame deletions, leading to β-globin variants in pediatric patients in Argentina. The HBB gene of the probands and their parents was sequenced, and other markers of globin chain imbalance were analyzed...
January 10, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29313196/tripartite-equilibrium-strategy-for-a-carbon-tax-setting-problem-in-air-passenger-transport
#6
Jiuping Xu, Rui Qiu, Zhimiao Tao, Heping Xie
Carbon emissions in air passenger transport have become increasing serious with the rapidly development of aviation industry. Combined with a tripartite equilibrium strategy, this paper proposes a multi-level multi-objective model for an air passenger transport carbon tax setting problem (CTSP) among an international organization, an airline and passengers with the fuzzy uncertainty. The proposed model is simplified to an equivalent crisp model by a weighted sum procedure and a Karush-Kuhn-Tucker (KKT) transformation method...
January 8, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29311689/multi-valued-and-fuzzy-logic-realization-using-taox-memristive-devices
#7
Debjyoti Bhattacharjee, Wonjoo Kim, Anupam Chattopadhyay, Rainer Waser, Vikas Rana
Among emerging non-volatile storage technologies, redox-based resistive switching Random Access Memory (ReRAM) is a prominent one. The realization of Boolean logic functionalities using ReRAM adds an extra edge to this technology. Recently, 7-state ReRAM devices were used to realize ternary arithmetic circuits, which opens up the computing space beyond traditional binary values. In this manuscript, we report realization of multi-valued and fuzzy logic operators with a representative application using ReRAM devices...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29302178/as-the-hiv-epidemic-among-young-women-grows-can-we-look-to-the-sdgs-to-reverse-the-trend
#8
Terry McGovern, Johanna Fine, Carolyn Crisp, Emily Battistini
To end the growing HIV epidemic among young women, human rights violations must be addressed. The Sustainable Development Goals have the potential to help, but only if political barriers are overcome and a rights-based approach is integrated.
December 2017: Health and Human Rights
https://www.readbyqxmd.com/read/29299734/modelling-of-adequate-and-safe-vitamin-d-intake-in-danish-women-using-different-fortification-and-supplementation-scenarios-to-inform-fortification-policies
#9
Ida M Grønborg, Inge Tetens, Majken Ege, Tue Christensen, Elisabeth Wreford Andersen, Rikke Andersen
PURPOSE: Fortification of foods with vitamin D may be a population-based solution to low vitamin D intake. We performed modelling of vitamin D from diet, fortified foods and supplements in a population of Danish women 18-50 years, a risk group of vitamin D deficiency, to inform fortification policies on safe and adequate levels. METHODS: Based on individual habitual dietary vitamin D intake of female participants from the Danish National Survey of Dietary Habits and Physical Activity (DANSDA) (n = 855), we performed graded intake modelling to predict the intake in six scenarios increasing the vitamin D intake from a habitual diet without fish to habitual diet including fish, fortified foods and supplements (40/80 µg)...
January 3, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29290310/baseline-total-kidney-volume-and-the-rate-of-kidney-growth-are-associated-with-chronic-kidney-disease-progression-in-autosomal-dominant-polycystic-kidney-disease
#10
Alan S L Yu, Chengli Shen, Douglas P Landsittel, Peter C Harris, Vicente E Torres, Michal Mrug, Kyongtae T Bae, Jared J Grantham, Frederic F Rahbari-Oskoui, Michael F Flessner, William M Bennett, Arlene B Chapman
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive enlargement of kidney cysts leading to chronic kidney disease (CKD) and end-stage renal disease (ESRD). Identification of an early biomarker that can predict progression of CKD is urgently needed. In an earlier Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) study (a prospective, multicenter, observational analysis of 241 patients with ADPKD initiated in 2000), baseline height-adjusted total kidney volume (htTKV) was shown to be associated with development of CKD stage 3 after eight years of follow-up...
December 28, 2017: Kidney International
https://www.readbyqxmd.com/read/29273924/changes-in-physical-activities-and-body-composition-after-roux-y-gastric-bypass-surgery
#11
Alex Harley Crisp, Rozangela Verlengia, Michele Novaes Ravelli, Irineu Rasera Junior, Maria Rita Marques de Oliveira
PURPOSE: Given the importance of physical activities for health outcomes, it is still unclear whether bariatric surgery per se and the standard care after surgery would result in an increase of physical activity level. This study aimed to determine physical activities preoperatively and at 6 and 12 months postoperatively among female patients who underwent bariatric surgery, and to investigate its relationship with body composition changes. MATERIAL AND METHODS: Thirty-four women who had Roux-Y gastric bypass (RYGB) surgery completed the study...
December 22, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29258868/when-exercise-does-not-pay-counterproductive-effects-of-impending-exercise-on-energy-intake-among-restrained-eaters
#12
Aaron Y Sim, Li Ling Lee, Bobby K Cheon
Evidence suggests people may overestimate the effectiveness of future positive behaviour, leading to counterproductive behaviours in the present. Applied to weight-management, we hypothesize that inaccurate expectations about impending exercise may impede weight management by promoting overconsumption prior to exercise. This study aimed to determine how expectations about impending exercise and its potential ability to expend energy may influence i) energy intake before exercise and ii) overall energy balance (energy intake minus energy expended via exercise)...
December 16, 2017: Appetite
https://www.readbyqxmd.com/read/29249923/an-exploration-of-socio-economic-and-food-characteristics-of-high-trans-fatty-acid-consumers-in-the-dutch-and-uk-national-surveys-after-voluntary-product-reformulation
#13
H L Rippin, J Hutchinson, M Ocke, J Jewell, J J Breda, J E Cade
Trans fatty acids (TFA) increase the risk of mortality and chronic diseases. TFA intakes have fallen since reformulation, but may still be high in certain, vulnerable, groups. This paper investigates socio-economic and food consumption characteristics of high TFA consumers after voluntary reformulation in the Netherlands and UK. Post-reformulation data of adults aged 19-64 was analysed in two national surveys: the Dutch National Food Consumption Survey (DNFCS) collected 2007-2010 using 2*24hr recalls (N = 1933) and the UK National Diet and Nutrition Survey (NDNS) years 3&4 collected 2010/11 and 2011/12 using 4-day food diaries (N = 848)...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29245864/computational-reconfigurable-imaging-spectrometer
#14
R M Sullenberger, A B Milstein, Y Rachlin, S Kaushik, C M Wynn
We demonstrate a novel hyperspectral imaging spectrometer based on computational imaging that enables sensitive measurements from smaller, noisier, and less-expensive components (e.g. uncooled microbolometers), making it useful for applications such as small space and air platforms with strict size, weight, and power requirements. The computational reconfigurable imaging spectrometer (CRISP) system exploits platform motion and a spectrally coded focal-plane mask to temporally modulate the optical spectrum, enabling simultaneous measurement of multiple spectral bins...
December 11, 2017: Optics Express
https://www.readbyqxmd.com/read/29237956/utility-of-the-laminin-immunohistochemical-stain-in-distinguishing-invasive-from-noninvasive-urothelial-carcinoma
#15
Dinesh Pradhan, Milon Amin, Shveta Hooda, Rajiv Dhir, Sheldon Bastacky, Anil V Parwani
BACKGROUND: To study the utility of the laminin immunostain in distinguishing invasive from noninvasive urothelial carcinoma (UC). The distinction is difficult but clinically significant as it can affect the decision to administer intravesical Bacillus Calmette-Guerin or can even lead to cystectomy. MATERIALS AND METHODS: Representative sections of the transurethral resection of bladder tumor specimens from 25 cases of formalin-fixed paraffin-embedded invasive UCs and 25 cases of noninvasive UCs were selected for immunohistochemical (IHC) staining with laminin (Ventana, Oro Valley, AZ, USA)...
October 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29234571/measurement-of-elevated-il-37-levels-in-acute-ischemic-brain-injury-a-cross-sectional-pilot-study
#16
Atif Zafar, Asad Ikram, Dinesh V Jillella, Duraisamy Kempuraj, Mohammad Moshahid Khan, Saif Bushnaq, Harold Adam, Santiago Ortega-Gutierrez, Syed A Quadri, Mudassir Farooqui, Asgar Zaheer, Enrique C Leira
Interleukin (IL)-37 is a new member of the IL-1 cytokine family with a defined role as a negative feedback inhibitor of proinflammatory responses. IL-37 has yet to be evaluated in non-immune-mediated neurological diseases, such as ischemic or hemorrhagic strokes. This study aimed to measure urine and serum IL-37 levels in patients with ischemic stroke. Twelve patients consented for our study. Two sets of serum and urine samples were obtained and analyzed, one upon admission to the hospital and the second the next morning...
October 11, 2017: Curēus
https://www.readbyqxmd.com/read/29231898/the-venom-of-the-spine-bellied-sea-snake-hydrophis-curtus-proteome-toxin-diversity-and-intraspecific-variation
#17
Vanessa Neale, Javier Sotillo, Jamie E Seymour, David Wilson
The spine-bellied sea snake (Hydrophis curtus) is known to cause human deaths, yet its venom composition has not yet been proteomically characterised. An indepth proteomic analysis was performed on H. curtus venom from two different seasons, January and June, corresponding to adults and subadults, respectively. Venoms from adult and subadult H. curtus individuals were compared using reversedphase high-performance liquid chromatography (RP-HPLC), matrix-assisted laser desorption ionisation-time of flight (MALDI-TOF) mass spectrometry and liquid chromatography electrospray ionisation mass spectrometry (LC-ESI-MS) to detect intraspecific variation, and the molecular weight data obtained with ESIMS were used to assess toxin diversity...
December 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29230357/comparative-analyses-of-putative-toxin-gene-homologs-from-an-old-world-viper-daboia-russelii
#18
Neeraja M Krishnan, Binay Panda
Availability of snake genome sequences has opened up exciting areas of research on comparative genomics and gene diversity. One of the challenges in studying snake genomes is the acquisition of biological material from live animals, especially from the venomous ones, making the process cumbersome and time-consuming. Here, we report comparative sequence analyses of putative toxin gene homologs from Russell's viper (Daboia russelii) using whole-genome sequencing data obtained from shed skin. When compared with the major venom proteins in Russell's viper studied previously, we found 45-100% sequence similarity between the venom proteins and their putative homologs in the skin...
2017: PeerJ
https://www.readbyqxmd.com/read/29222525/conserved-gene-microsynteny-unveils-functional-interaction-between-protein-disulfide-isomerase-and-rho-guanine-dissociation-inhibitor-families
#19
Ana I S Moretti, Jessyca C Pavanelli, Patrícia Nolasco, Matthias S Leisegang, Leonardo Y Tanaka, Carolina G Fernandes, João Wosniak, Daniela Kajihara, Matheus H Dias, Denise C Fernandes, Hanjoong Jo, Ngoc-Vinh Tran, Ingo Ebersberger, Ralf P Brandes, Diego Bonatto, Francisco R M Laurindo
Protein disulfide isomerases (PDIs) support endoplasmic reticulum redox protein folding and cell-surface thiol-redox control of thrombosis and vascular remodeling. The family prototype PDIA1 regulates NADPH oxidase signaling and cytoskeleton organization, however the related underlying mechanisms are unclear. Here we show that genes encoding human PDIA1 and its two paralogs PDIA8 and PDIA2 are each flanked by genes encoding Rho guanine-dissociation inhibitors (GDI), known regulators of RhoGTPases/cytoskeleton...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29215511/liposomal-bupivacaine-during-robotic-colpopexy-and-posterior-repair-a-randomized-controlled-trial
#20
Jennifer Yeung, Catrina C Crisp, Donna Mazloomdoost, Steven D Kleeman, Rachel N Pauls
OBJECTIVE: To evaluate the effect of liposomal bupivacaine on postoperative pain among patients undergoing robotic sacrocolpopexy with posterior repair. METHODS: This was a randomized, patient-blinded, placebo-controlled trial of women undergoing robotic sacrocolpopexy with posterior repair. Liposomal bupivacaine or normal saline placebo was injected into laparoscopic and vaginal incisions at completion of surgery. Perioperative care was standardized. Visual analog scales were collected at 4, 18, and 24 hours postoperatively in hospital...
January 2018: Obstetrics and Gynecology
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