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https://www.readbyqxmd.com/read/28811976/long-lived-pancreatic-ductal-adenocarcinoma-slice-cultures-enable-precise-study-of-the-immune-microenvironment
#1
Xiuyun Jiang, Y David Seo, Jae Hyuck Chang, Andrew Coveler, Eslam N Nigjeh, Sheng Pan, Florencia Jalikis, Raymond S Yeung, Ian N Crispe, Venu G Pillarisetty
Pancreatic ductal adenocarcinoma (PDA) remains a deadly disease that is rarely cured, despite many recent successes with immunotherapy for other malignancies. As the human disease is heavily infiltrated by effector T cells, we postulated that accurately modeling the PDA immune microenvironment would allow us to study mechanisms of immunosuppression that could be overcome for therapeutic benefit. Using viable precision-cut slices from fresh PDA, we developed an organotypic culture system for this purpose. We confirmed that cultured slices maintain their baseline morphology, surface area, and microenvironment after at least 6 d in culture, and demonstrated slice survival by MTT assay and by immunohistochemistry staining with Ki-67 and cleaved-Caspase-3 antibodies...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28811755/a-novel-recombined-potato-virus-y-isolate-in-china
#2
Shuxin Han, Yanling Gao, Guoquan Fan, Wei Zhang, Cailing Qiu, Shu Zhang, Yanju Bai, Junhua Zhang, Carl Spetz
This study reports the findings of a distinct Potato virus Y (PVY) isolate found in Northeast China. One hundred and ten samples (leaves and tubers) were collected from potato plants showing mosaic symptoms around the city of Harbin in Heilongjiang province of China. The collected tubers were planted and let to grow in a greenhouse. New potato plants generated from these tubers showed similar symptoms, except for one plant. Subsequent serological analyses revealed PVY as the causing agent of the disease. A novel PVY isolate (referred to as HLJ-C-44 in this study) was isolated from this sample showing unique mild mosaic and crisped leaf margin symptoms...
August 2017: Plant Pathology Journal
https://www.readbyqxmd.com/read/28811114/determination-of-acrylamide-levels-in-potato-crisps-and-other-snacks-and-exposure-risk-assessment-through-a-margin-of-exposure-approach
#3
Francesco Esposito, Antonio Nardone, Evelina Fasano, Maria Triassi, Teresa Cirillo
Potato crisps, corn-based extruded snacks and other savoury snacks are very popular products especially among younger generations. These products could be a potential source of acrylamide (AA), a toxic compound which could develop during frying and baking processes. The purpose of this study was the assessment of the dietary intake to AA across six groups of consumers divided according to age through the consumption of potato crisps and other snacks, in order to eventually evaluate the margin of exposure (MOE) related to neurotoxic and carcinogenic critical endpoints...
August 12, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28797621/influence-of-acute-myeloid-leukemia-progression-on-the-prognosis-of-831-patients-with-myelodysplastic-syndromes-from-the-argentine-database
#4
Alicia Enrico, Yesica Bestach, Maria Gabriela Flores, Jorge Arbelbide, Camila Serale, Viviana Novoa, Renée Crisp, María Marta Rivas, Irene Larripa, Carolina Belli
BACKGROUND: A large group of patients with myelodysplastic syndromes (MDS) will die of causes intrinsic to bone marrow failure. One third of patients will develop acute myeloid leukemia (AML), which is associated with an extremely poor outcome and a short survival. Our objectives were to analyze the prognostic variables and scoring systems in the attempt to determine the influence of progression on the overall survival of MDS patients. PATIENTS AND METHODS: We performed a retrospective analysis of 831 MDS patients, including those from the Argentine Registry...
June 23, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28792897/partial-membership-latent-dirichlet-allocation-for-soft-image-segmentation
#5
Chao Chen, Alina Zare, Huy N Trinh, Gbenga O Omotara, J Tory Cobb, Timotius A Lagaunne
Topic models (e.g., pLSA, LDA, sLDA) have been widely used for segmenting imagery. However, these models are confined to crisp segmentation, forcing a visual word (i.e., an image patch) to belong to one and only one topic. Yet, there are many images in which some regions cannot be assigned a crisp categorical label (e.g., transition regions between a foggy sky and the ground or between sand and water at a beach). In these cases, a visual word is best represented with partial memberships across multiple topics...
August 4, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28752938/dendritic-cells-in-hepatitis-and-liver-transplantation
#6
Radika Soysa, Xia Wu, I Nicholas Crispe
Dendritic cells (DCs) play a key role in innate immune responses, and are also the most effective cells for the activation of T cell immunity. They acquire antigen and process it, then display in on the cell surface bound in a non-covalent complex with HLA molecules of class I (HLA-A, B, C) and class II (HLA-DR). These cells are subdivided into three main subsets, two called myeloid or classical DCs of types 1 and 2, and one called plasmacytoid. The myeloid DCs process and present antigen, while the plasmacytoid DCs also strongly respond to viral signals by secreting Type 1 Interferon...
July 28, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28737692/salt-reductions-in-some-foods-in-the-netherlands-monitoring-of-food-composition-and-salt-intake
#7
Elisabeth H M Temme, Marieke A H Hendriksen, Ivon E J Milder, Ido B Toxopeus, Susanne Westenbrink, Henny A M Brants, Daphne L van der A
BACKGROUND AND OBJECTIVES: High salt intake increases blood pressure and thereby the risk of chronic diseases. Food reformulation (or food product improvement) may lower the dietary intake of salt. This study describes the changes in salt contents of foods in the Dutch market over a five-year period (2011-2016) and differences in estimated salt intake over a 10-year period (2006-2015). METHODS: To assess the salt contents of foods; we obtained recent data from chemical analyses and from food labels...
July 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28717615/outcomes-of-prolotherapy-for-intra-tendinous-achilles-tears-a-case-series
#8
Otto Chan, Ben Havard, Sarah Morton, Mel Pritchard, Nicola Maffulli, Tom Crisp, Nat Padhiar, Jeremy David Perry, John King, Dylan Morrissey
BACKGROUND: The intra-tendinous tear is a new pathology that is defined as a discontinuity of fibres situated entirely within the tendon. Prolotherapy involves injecting an irritant, such as hyperosmolar dextrose, to stimulate a tissue healing response and ultimately reduce pain. METHODS: 43 consecutive patients diagnosed with an intra-tendinous tear were included (27 males: 16 females, mean (SD) age 41 (11.3). Patients were injected with 0.4ml-1.5ml (mean 0.8ml) of 50% dextrose and 0...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28717612/intratendinous-tears-of-the-achilles-tendon-a-new-pathology-analysis-of-a-large-4-year-cohort
#9
Otto Chan, Sarah Morton, Mel Pritchard, Tina Parkes, Peter Malliaras, Tom Crisp, Nat Padhiar, Nicola Maffulli, John King, Dylan Morrissey
BACKGROUND: Achillodynia is common and includes Achilles tendinopathy, partial Achilles tears and Achilles tendon ruptures. However, we believe an additional pathology should be considered for Achillodynia differentials - the intratendinous tear (ITT). METHODS: Examinations of 740 achillodynic patients in one specialist centre were reviewed. ITTs were defined as a clearly visualised echopoor area situated centrally and extending to, but not through the tendon periphery, with pain on palpation and no clinical findings consistent with Achilles rupture...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28705956/rapid-recovery-gene-downregulation-during-excess-light-stress-and-recovery-in-arabidopsis
#10
Peter Alexander Crisp, Diep Ganguly, Aaron B Smith, Kevin D Murray, Gonzalo M Estavillo, Iain R Searle, Ethan Ford, Ozren Bogdanović, Ryan Lister, Justin O Borevitz, Steven R Eichten, Barry J Pogson
Stress recovery may prove to be a promising approach to increase plant performance, and theoretically, mRNA instability may facilitate faster recovery. Transcriptome (RNA-seq, qPCR, sRNA-seq, PARE) and methylome profiling during repeated excess-light stress and recovery was performed at intervals as short as three minutes. We demonstrate that 87% of the stress-upregulated mRNAs analysed exhibit very rapid recovery. For instance, HSP101 abundance declined two-fold every 5.1 minutes. We term this phenomenon Rapid Recovery Gene Downregulation (RRGD), whereby mRNA abundance rapidly decreases promoting transcriptome resetting...
July 13, 2017: Plant Cell
https://www.readbyqxmd.com/read/28694151/liposomal-bupivacaine-decreases-pain-following-retropubic-sling-placement-a-randomized-placebo-controlled-trial
#11
Donna Mazloomdoost, Rachel N Pauls, Erin N Hennen, Jennifer Y Yeung, Benjamin C Smith, Steven D Kleeman, Catrina C Crisp
BACKGROUND: Midurethral slings are commonly used to treat stress urinary incontinence. Pain control, however, may be a concern. Liposomal bupivacaine is a local anesthetic with slow release over 72 hours, demonstrated to lower pain scores and decrease narcotic use postoperatively. OBJECTIVE: The purpose of this study was to examine the impact of liposomal bupivacaine on pain scores and narcotic consumption following retropubic midurethral sling placement. STUDY DESIGN: This randomized, placebo-controlled trial enrolled women undergoing retropubic midurethral sling procedures with or without concomitant anterior or urethrocele repair...
July 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28689457/survey-on-acrylamide-in-roasted-coffee-and-barley-and-in-potato-crisps-sold-in-italy-by-a-lc-ms-ms-method
#12
Terenzio Bertuzzi, Silvia Rastelli, Annalisa Mulazzi, Amedeo Pietri
A survey on the occurrence of acrylamide (AA) in roasted coffee, barley and potato crisps was carried out using an intra-lab validated LC-MS/MS method. Over the years 2015-2016, 66 samples of coffee, 22 of roasted barley and 22 of potato crisps were collected from retail outlets in Italy. AA was detected in almost all samples. In roasted coffee, the level exceeded 450 µg kg(-1), the limit recommended by the European Commission (EC), in 36.4% of the samples. In roasted barley, mean contamination was slightly lower than in coffee and no sample exceeded the EC limit of 2000 µg kg(-1)...
July 10, 2017: Food Additives & Contaminants. Part B, Surveillance
https://www.readbyqxmd.com/read/28688916/venom-proteome-of-the-yellow-lipped-sea-krait-laticauda-colubrina-from-bali-insights-into-subvenomic-diversity-venom-antigenicity-and-cross-neutralization-by-antivenom
#13
Choo Hock Tan, Kin Ying Wong, Kae Yi Tan, Nget Hong Tan
The venom proteome of Laticauda colubrina (Bali, Indonesia) was elucidated by nano-ESI-LCMS/MS of the venom reverse-phase HPLC fractions. Altogether 31 distinct forms of proteins were identified and clustered into three toxin families: three-finger toxin (3FTX, 66.12% of total venom proteins), phospholipase A2 (PLA2, 33.26%) and cysteine-rich secretory protein (CRiSP, 0.05%). The 3FTX were α-neurotoxins (five long neurotoxins, LNTX, 48.87%; two short neurotoxins, SNTX, 16.94%) and a trace amount of two cytotoxins (CTX, 0...
July 5, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28688515/the-triple-impact-of-nursing
#14
EDITORIAL
Lord Crisp, Baroness Mary Watkins Of Tavistock
No abstract text is available yet for this article.
May 11, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28671034/acrylamide-in-commercial-foods-and-intake-by-infants-in-estonia
#15
Andres Elias, Mati Roasto, Mari Reinik, Keiu Nelis, Eha Nurk, Terje Elias
Acrylamide is formed when certain foods with low moisture are prepared at above 120 ºC, especially those foods containing asparagine and reducing sugars such as glucose and fructose. Acrylamide is a probable carcinogen, and from animal evidence the margins of exposure indicate a concern for neoplastic effects. On a body weight basis infants´ acrylamide intakes are often higher than those of adults. The aim of the study was to determine acrylamide levels in different commercially-available foods and to assess dietary acrylamide intakes by infants...
July 10, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28657993/outcomes-and-characteristics-of-patients-undergoing-surgical-management-for-mesh-related-complications
#16
Donna Mazloomdoost, Rachel N Pauls, Steven D Kleeman, Catrina C Crisp
OBJECTIVE: The aims of this study were to describe the characteristics of women presenting with mesh-related complications and evaluate postoperative quality of life, sexual functioning, and patient-perceived outcomes. METHODS: This institutional review board-approved study included a retrospective chart review and a cross-sectional follow-up with validated questionnaires. Demographics and medical histories were collected from charts of women treated for mesh-related complaints between 2010 and 2014...
June 27, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28657649/application-of-pretreatment-methods-on-agricultural-products-prior-to-frying-a-review
#17
REVIEW
Ayobami Olayemi Oladejo, Haile Ma, Wenjuan Qu, Cunshan Zhou, Bengang Wu, Uzoejinwa Benjamin Bernard, Daniel I Onwude, Xue Yang
Frying is one of the methods of processing foods, which imparts flavour, taste, colour and crispness in the fried foods. In spite an increase in the demand for fried foods by consumers all over the world, the danger posed by consuming too much fat is still a challenge. Many researchers have come up with many ideas on how to reduce the oil uptake and improve the nutritional and organoleptic qualities of foods during frying. Several pretreatments techniques applied to food materials prior to frying have been investigated by researchers in a bid to reduce the oil uptake and improve the quality parameters of fried foods...
June 28, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28657478/promoting-beliefs-in-the-inalienability-of-human-rights-by-attributing-uniquely-human-emotions-through-multiple-categorization
#18
Flavia Albarello, Richard Crisp, Monica Rubini
The combination of multiple categorization (i.e., the use of multiple criteria to define others) and human identity-the superordinate group of human beings-has recently been highlighted as a method to reduce implicit (i.e., attribution of secondary emotions) and explicit (i.e., attribution of human rights) dehumanization towards Blacks. In two studies aimed to replicate such evidence the mediating role of secondary emotions in explaining the impact of multiple and human categorization in reducing dehumanization was assessed...
June 28, 2017: Journal of Social Psychology
https://www.readbyqxmd.com/read/28645994/improvement-of-patient-wait-times-in-an-outpatient-pharmacy
#19
James P Amerine, Tippu Khan, Brett Crisp
No abstract text is available yet for this article.
July 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28645593/the-healthcare-landscape-are-doctors-agents-of-change-or-impediments-to-change
#20
Russell J Andrews, Nigel Crisp
No abstract text is available yet for this article.
June 20, 2017: World Neurosurgery
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