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https://www.readbyqxmd.com/read/29160555/the-effect-of-sleep-disorders-sedating-medications-and-depression-on-cognitive-processing-therapy-outcomes-a-fuzzy-set-qualitative-comparative-analysis
#1
Patricia L Haynes, Sarah E Emert, Dana Epstein, Suzanne Perkins, Sairam Parthasarathy, James Wilcox
Cognitive processing therapy (CPT) for posttraumatic stress disorder (PTSD) is an effortful process requiring engagement in cognitive restructuring. Sleep disorders may lead to avoidance of effortful tasks and cognitive performance deficits. We explored whether sleep disorders, as assessed by polysomnography, were consistently associated with treatment response in combination with other factors. This study included 32 U.S. veterans who were examined both before and after CPT for combat-related PTSD. We employed a novel, case-comparative technique, fuzzy set qualitative comparative analysis (fsQCA), to identify combinations of fuzzy and crisp factors (recipes) that achieve a clinically significant outcome...
November 21, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29159291/continuum-reconfigurable-parallel-robots-for-surgery-shape-sensing-and-state-estimation-with-uncertainty
#2
Patrick L Anderson, Arthur W Mahoney, Robert J Webster
This paper examines shape sensing for a new class of surgical robot that consists of parallel flexible structures that can be reconfigured inside the human body. Known as CRISP robots, these devices provide access to the human body through needle-sized entry points, yet can be configured into truss-like structures capable of dexterous movement and large force application. They can also be reconfigured as needed during a surgical procedure. Since CRISP robots are elastic, they will deform when subjected to external forces or other perturbations...
July 2017: IEEE Robotics and Automation Letters
https://www.readbyqxmd.com/read/29154885/consumers-health-related-perceptions-of-bread-implications-for-labeling-and-health-communication
#3
Pernilla Sandvik, Margaretha Nydahl, Iwona Kihlberg, Ingela Marklinder
There is a wide variety of commercial bread types and the present study identifies potential pitfalls in consumer evaluations of bread from a health perspective. The aim is to describe consumers' health-related perceptions of bread by exploring which health-related quality attributes consumers associate with bread and whether there are differences with regard to age, gender and education level. A postal and web-based sequential mixed-mode survey (n = 1134, 63% responded online and 37% by paper) with open-ended questions and an elicitation task with pictures of commercial breads were used...
November 14, 2017: Appetite
https://www.readbyqxmd.com/read/29143716/the-shelf-space-and-strategic-placement-of-healthy-and-discretionary-foods-in-urban-urban-fringe-and-rural-non-metropolitan-australian-supermarkets
#4
Adrian J Cameron
OBJECTIVE: Supermarkets are a key influence on eating behaviours, but it is unknown if the promotion of food within stores varies on a geographic gradient from urban, to urban-fringe and non-metropolitan areas. The present study aimed to assess the shelf space and strategic placement of healthy and discretionary foods in each of urban, urban-fringe and non-metropolitan Australian supermarkets. Design/Setting In-store audits were conducted in stores from one of the two major Australian supermarket chains in urban (n 19), urban-fringe (n 20) and non-metropolitan (n 26) areas of Victoria...
November 16, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29132916/insulin-degrading-enzyme-in-the-fight-against-alzheimer-s-disease
#5
REVIEW
Igor V Kurochkin, Enrico Guarnera, Igor N Berezovsky
After decades of research and clinical trials there is still no cure for Alzheimer's disease (AD). While impaired clearance of amyloid beta (Aβ) peptides is considered as one of the major causes of AD, it was recently complemented by a potential role of other toxic amyloidogenic species. Insulin-degrading enzyme (IDE) is the proteolytic culprit of various β-forming peptides, both extracellular and intracellular. On the basis of demonstrated allosteric activation of IDE against Aβ, it is possible to propose a new strategy for the targeted IDE-based cleansing of different toxic aggregation-prone peptides...
November 10, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/29111587/multifractal-approaches-of-the-ring-tensile-rupture-patterns-of-dried-laver-porphyra-as-affected-by-the-relative-humidity
#6
Hwabin Jung, Won Byong Yoon
The effect of water activity (aw ) or the relative humidity (RH) on the tensile rupture properties of dried laver (DL) associated with structures formed with phycocolloids was investigated. The morphological characteristics of tensile ruptured DL samples at various relative humidities were evaluated by multifractal analysis. The RH of the microclimate was controlled from 10% to 90% at 25 °C using supersaturated salt solutions. The sorption isotherm of DL was experimentally obtained and quantitatively analyzed using mathematical models...
November 7, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29100391/gene-expression-information-improves-reliability-of-receptor-status-in-breast-cancer-patients
#7
Michael Kenn, Karin Schlangen, Dan Cacsire Castillo-Tong, Christian F Singer, Michael Cibena, Heinz Koelbl, Wolfgang Schreiner
Immunohistochemical (IHC) determination of receptor status in breast cancer patients is frequently inaccurate. Since it directs the choice of systemic therapy, it is essential to increase its reliability. We increase the validity of IHC receptor expression by additionally considering gene expression (GE) measurements. Crisp therapeutic decisions are based on IHC estimates, even if they are borderline reliable. We further improve decision quality by a responsibility function, defining a critical domain for gene expression...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29081761/imagined-steps-mental-simulation-of-coordinated-rhythmic-movements-effects-on-pro-sociality
#8
Liam Cross, Gray Atherton, Andrew D Wilson, Sabrina Golonka
Rhythmically coordinating with a partner can increase pro-sociality, but pro-sociality does not appear to change in proportion to coordination success, or particular classes of coordination. Pro-social benefits may have more to do with simply coordinating in a social context than the details of the actual coordination (Cross et al., 2016). This begs the question, how stripped down can a coordination task be and still affect pro-sociality? Would it be sufficient simply to imagine coordinating with others? Imagining a social interaction can lead to many of the same effects as actual interaction (Crisp and Turner, 2009)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29071358/tracing-the-evolutionary-history-of-the-cap-superfamily-of-proteins-using-amino-acid-sequence-homology-and-conservation-of-splice-sites
#9
Anup Abraham, Douglas E Chandler
Proteins of the CAP superfamily play numerous roles in reproduction, innate immune responses, cancer biology, and venom toxicology. Here we document the breadth of the CAP (Cysteine-RIch Secretory Protein (CRISP), Antigen 5, and Pathogenesis-Related) protein superfamily and trace the major events in its evolution using amino acid sequence homology and the positions of exon/intron borders within their genes. Seldom acknowledged in the literature, we find that many of the CAP subfamilies present in mammals, where they were originally characterized, have distinct homologues in the invertebrate phyla...
October 2017: Journal of Molecular Evolution
https://www.readbyqxmd.com/read/29058904/formation-of-a-hydroxymethylfurfural-cysteine-adduct-and-its-absorption-and-cytotoxicity-in-caco-2-cells
#10
Qianzhu Zhao, Yueyu Zou, Caihuan Huang, Ping Lan, Jie Zheng, Shiyi Ou
Adducts of 5-hydroxymethylfurfural (HMF)-amino acids are formed during food processing and digestion; the elimination capacity of in vitro intestinal digests of biscuits, instant noodles, and potato crisps for HMF is 652, 727, and 540 μg/g, respectively. However, the safety of these adducts is unknown. In this study, an HMF-cysteine adduct named 1-dicysteinethioacetal-5-hydroxymehtylfurfural (DCH), which was found to be produced in the gastrointestinal tract after HMF intake, was prepared to test its effect toward Caco-2 cells...
October 31, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29054255/predicting-cd4-count-changes-among-patients-on-antiretroviral-treatment-application-of-data-mining-techniques
#11
Mihiretu Kebede, Desalegn Tigabu Zegeye, Berihun Megabiaw Zeleke
BACKGROUND AND OBJECTIVES: To monitor the progress of therapy and disease progression, periodic CD4 counts are required throughout the course of HIV/AIDS care and support. The demand for CD4 count measurement is increasing as ART programs expand over the last decade. This study aimed to predict CD4 count changes and to identify the predictors of CD4 count changes among patients on ART. METHODS: A cross-sectional study was conducted at the University of Gondar Hospital from 3,104 adult patients on ART with CD4 counts measured at least twice (baseline and most recent)...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29051612/the-orbiting-carbon-observatory-oco-2-tracks-2-3-peta-gram-increase-in-carbon-release-to-the-atmosphere-during-the-2014-2016-el-ni%C3%A3-o
#12
Prabir K Patra, David Crisp, Johannes W Kaiser, Debra Wunch, Tazu Saeki, Kazuhito Ichii, Takashi Sekiya, Paul O Wennberg, Dietrich G Feist, David F Pollard, David W T Griffith, Voltaire A Velazco, M De Maziere, Mahesh K Sha, Coleen Roehl, Abhishek Chatterjee, Kentaro Ishijima
The powerful El Niño event of 2015-2016 - the third most intense since the 1950s - has exerted a large impact on the Earth's natural climate system. The column-averaged CO2 dry-air mole fraction (XCO2) observations from satellites and ground-based networks are analyzed together with in situ observations for the period of September 2014 to October 2016. From the differences between satellite (OCO-2) observations and simulations using an atmospheric chemistry-transport model, we estimate that, relative to the mean annual fluxes for 2014, the most recent El Niño has contributed to an excess CO2 emission from the Earth's surface (land + ocean) to the atmosphere in the range of 2...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29045911/fuzzy-rough-cognitive-networks
#13
Gonzalo Nápoles, Carlos Mosquera, Rafael Falcon, Isel Grau, Rafael Bello, Koen Vanhoof
Rough Cognitive Networks (RCNs) are a kind of granular neural network that augments the reasoning rule present in Fuzzy Cognitive Maps with crisp information granules coming from Rough Set Theory. While RCNs have shown promise in solving different classification problems, this model is still very sensitive to the similarity threshold upon which the rough information granules are built. In this paper, we cast the RCN model within the framework of fuzzy rough sets in an attempt to eliminate the need for a user-specified similarity threshold while retaining the model's discriminatory power...
September 28, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29035546/gradient-adaptive-decomposition-grad-method-optimized-refinement-along-macrostate-borders-in-markov-state-models
#14
P G Romano, M G Guenza
Markov state models (MSM) are used to model the kinetics of processes sampled by molecular dynamics (MD) simulations. MSM reduce the high dimensionality inherent to MD simulations as they partition the free energy landscape into discrete states, generating a kinetic model as a series of uncorrelated jumps between states. Here, we detail a new method, called GRadient Adaptive Decomposition, which optimizes coarse-grained MSM by refining borders with respect to the gradient along the free energy surface. The proposed method requires only a small number of initial microstates because it corrects for errors produced by limited sampling...
October 31, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29030107/ammodytin-l-is-the-main-cardiotoxic-component-of-the-vipera-ammodytes-ammodytes-venom
#15
Svjetlana Karabuva, Boris Lukšić, Ivica Brizić, Zorica Latinović, Adrijana Leonardi, Igor Križaj
Venom of the nose-horned viper (V. a. ammodytes) as also venoms of some related European viperids can induce also cardiotoxic effects in mammals. In this work we demonstrated that the protein in the V. a. ammodytes venom acting on heart is a myotoxic secreted phospholipase A2 analogue ammodytin L (AtnL). In the isolated perfused rat heart AtnL induced significant and irreversible cardiotoxicity characterized by atrioventricular (AV) blockade. This venom protein induced appearance of high levels of creatine kinase, lactate dehydrogenase, aspartate aminotransferase and troponin I in the sinus effluent of the isolated heart, indicative for myocardial damage, which is obviously the primary cause of its cardiotoxic action...
December 1, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29026015/spaceborne-detection-of-localized-carbon-dioxide-sources
#16
Florian M Schwandner, Michael R Gunson, Charles E Miller, Simon A Carn, Annmarie Eldering, Thomas Krings, Kristal R Verhulst, David S Schimel, Hai M Nguyen, David Crisp, Christopher W O'Dell, Gregory B Osterman, Laura T Iraci, James R Podolske
Spaceborne measurements by NASA's Orbiting Carbon Observatory-2 (OCO-2) at the kilometer scale reveal distinct structures of atmospheric carbon dioxide (CO2) caused by known anthropogenic and natural point sources. OCO-2 transects across the Los Angeles megacity (USA) show that anthropogenic CO2 enhancements peak over the urban core and decrease through suburban areas to rural background values more than ~100 kilometers away, varying seasonally from ~4.4 to 6.1 parts per million. A transect passing directly downwind of the persistent isolated natural CO2 plume from Yasur volcano (Vanuatu) shows a narrow filament of enhanced CO2 values (~3...
October 13, 2017: Science
https://www.readbyqxmd.com/read/29026014/influence-of-el-ni%C3%A3-o-on-atmospheric-co2-over-the-tropical-pacific-ocean-findings-from-nasa-s-oco-2-mission
#17
A Chatterjee, M M Gierach, A J Sutton, R A Feely, D Crisp, A Eldering, M R Gunson, C W O'Dell, B B Stephens, D S Schimel
Spaceborne observations of carbon dioxide (CO2) from the Orbiting Carbon Observatory-2 are used to characterize the response of tropical atmospheric CO2 concentrations to the strong El Niño event of 2015-2016. Although correlations between the growth rate of atmospheric CO2 concentrations and the El Niño-Southern Oscillation are well known, the magnitude of the correlation and the timing of the responses of oceanic and terrestrial carbon cycle remain poorly constrained in space and time. We used space-based CO2 observations to confirm that the tropical Pacific Ocean does play an early and important role in modulating the changes in atmospheric CO2 concentrations during El Niño events-a phenomenon inferred but not previously observed because of insufficient high-density, broad-scale CO2 observations over the tropics...
October 13, 2017: Science
https://www.readbyqxmd.com/read/29026012/the-orbiting-carbon-observatory-2-early-science-investigations-of-regional-carbon-dioxide-fluxes
#18
A Eldering, P O Wennberg, D Crisp, D S Schimel, M R Gunson, A Chatterjee, J Liu, F M Schwandner, Y Sun, C W O'Dell, C Frankenberg, T Taylor, B Fisher, G B Osterman, D Wunch, J Hakkarainen, J Tamminen, B Weir
NASA's Orbiting Carbon Observatory-2 (OCO-2) mission was motivated by the need to diagnose how the increasing concentration of atmospheric carbon dioxide (CO2) is altering the productivity of the biosphere and the uptake of CO2 by the oceans. Launched on 2 July 2014, OCO-2 provides retrievals of the column-averaged CO2 dry-air mole fraction ([Formula: see text]) as well as the fluorescence from chlorophyll in terrestrial plants. The seasonal pattern of uptake by the terrestrial biosphere is recorded in fluorescence and the drawdown of [Formula: see text] during summer...
October 13, 2017: Science
https://www.readbyqxmd.com/read/29026011/contrasting-carbon-cycle-responses-of-the-tropical-continents-to-the-2015-2016-el-ni%C3%A3-o
#19
Junjie Liu, Kevin W Bowman, David S Schimel, Nicolas C Parazoo, Zhe Jiang, Meemong Lee, A Anthony Bloom, Debra Wunch, Christian Frankenberg, Ying Sun, Christopher W O'Dell, Kevin R Gurney, Dimitris Menemenlis, Michelle Gierach, David Crisp, Annmarie Eldering
The 2015-2016 El Niño led to historically high temperatures and low precipitation over the tropics, while the growth rate of atmospheric carbon dioxide (CO2) was the largest on record. Here we quantify the response of tropical net biosphere exchange, gross primary production, biomass burning, and respiration to these climate anomalies by assimilating column CO2, solar-induced chlorophyll fluorescence, and carbon monoxide observations from multiple satellites. Relative to the 2011 La Niña, the pantropical biosphere released 2...
October 13, 2017: Science
https://www.readbyqxmd.com/read/29023810/development-of-functional-extruded-snacks-by-utilizing-paste-shrimp-acetes-spp-process-optimization-and-quality-evaluation
#20
Raushan Kumar, K A Martin Xavier, Manjusha Lekshmi, Vignaesh Dhanabalan, Madonna T Thachil, Amjad K Balange, Venkateshwarlu Gudipati
BACKGROUND: Functional extruded snacks were prepared using paste shrimp powder (Acetes spp.) which is rich in protein content. The process variables required for the preparation of extruded snacks was optimized using response surface methodology. Extrusion temperature (130 - 144 °C), level of Acetes powder (100 - 200 g kg(-1) ) and feed moisture (140 - 200 g kg(-1) ) were selected as design variables, and expansion ratio, porosity, hardness, crispness and thiobarbituric acid reactive substance value were taken as the response variables...
October 10, 2017: Journal of the Science of Food and Agriculture
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