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Zilong Sun, Sujuan Li, Yuxiang Yu, Hongyu Chen, Mohammad Mehdi Ommati, Ram Kumar Manthari, Ruiyan Niu, Jundong Wang
It is well known that high fluoride results in low fertility. Epididymis is the important place for spermatozoa maturation, which is essential for successful fertilization. In the previous studies, fluoride was reported to damage the epididymal structure of mouse and rabbit. However, the mechanism underlying sodium fluoride (NaF)-induced epididymal toxicity has not yet been well elucidated. The aim of this study is to explore the global protein alterations in epididymis of mice exposed to NaF using the iTRAQ technique...
September 16, 2017: Archives of Toxicology
Haijun Li, Naicui Zhai, Zhongfeng Wang, Hongxiao Song, Yang Yang, An Cui, Tianyang Li, Guangyi Wang, Junqi Niu, Ian Nicholas Crispe, Lishan Su, Zhengkun Tu
BACKGROUND AND AIMS: HBV infection represents a major health problem worldwide, but the immunological mechanisms by which HBV causes chronic persistent infection remain only partly understood. Recently, cell subsets with suppressive features have been recognised among monocytes and natural killer (NK) cells. Here we examine the effects of HBV on monocytes and NK cells. METHODS: Monocytes and NK cells derived from chronic HBV-infected patients and healthy controls were purified and characterised for phenotype, gene expression and cytokines secretion by flow cytometry, quantitative real-time (qRT)-PCR, ELISA and western blotting...
September 12, 2017: Gut
Sachith Mettananda, Chris A Fisher, Deborah Hay, Mohsin Badat, Lynn Quek, Kevin Clark, Philip Hublitz, Damien Downes, Jon Kerry, Matthew Gosden, Jelena Telenius, Jackie A Sloane-Stanley, Paula Faustino, Andreia Coelho, Jessica Doondeea, Batchimeg Usukhbayar, Paul Sopp, Jacqueline A Sharpe, Jim R Hughes, Paresh Vyas, Richard J Gibbons, Douglas R Higgs
β-Thalassemia is one of the most common inherited anemias, with no effective cure for most patients. The pathophysiology reflects an imbalance between α- and β-globin chains with an excess of free α-globin chains causing ineffective erythropoiesis and hemolysis. When α-thalassemia is co-inherited with β-thalassemia, excess free α-globin chains are reduced significantly ameliorating the clinical severity. Here we demonstrate the use of CRISPR/Cas9 genome editing of primary human hematopoietic stem/progenitor (CD34+) cells to emulate a natural mutation, which deletes the MCS-R2 α-globin enhancer and causes α-thalassemia...
September 4, 2017: Nature Communications
Nigel Crisp
No abstract text is available yet for this article.
September 4, 2017: BMJ: British Medical Journal
Emanuele Marino, Thomas Edward Kodger, Ryan William Crisp, Dolf Timmerman, Katherine E MacArthur, Marc Heggen, Peter Schall
Solar devices based on semiconductor nanoparticles require the use of conductive ligands; however, replacing the native, insulating ligands with conductive metal chalcogenide complexes introduces structural defects within the crystalline nanostructure that act as traps for charge carriers. We utilize atomically thin semiconductor nanoplatelets as a convenient platform for studying both microscopically, and spectroscopically, the development of defects during ligand exchange with conductive ligands Na4SnS4 and (NH4)4Sn2S6...
September 3, 2017: Angewandte Chemie
Małgorzata Tańska, Iwona Konopka, Millena Ruszkowska
This study compares the quality of extrudates made from corn grits with the addition of up to 8% of spirulina powder. The sensory properties (shape, color, aroma, taste and crispness), chemicals (content of water, protein, fat, ash, fiber, carbohydrates, carotenoids, chlorophyll and phycocyanin) and physical properties (color, water absorption index, expansion indices, texture and water sorption properties) were determined. It has been found that spirulina-enriched extrudates had slightly lower sensory scores, but the addition of spirulina improved their nutritional value...
September 2, 2017: Plant Foods for Human Nutrition
Salehe Erfanian Ebadi, Ebroul Izquierdo
Background subtraction is a fundamental video analysis technique that consists of creation of a background model that allows distinguishing foreground pixels. We present a new method in which the image sequence is assumed to be made up of the sum of a low-rank background matrix and a dynamic tree-structured sparse matrix. The decomposition task is then solved using our approximated Robust Principal Component Analysis (ARPCA) method which is an extension to the RPCA that can handle camera motion and noise. Our model dynamically estimates the support of the foreground regions via a superpixel generation step, so that spatial coherence can be imposed on these regions...
August 29, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
Alexandra Usuga, Benjamín A Rojano, Giovanni Restrepo
Contribution of seminal plasma proteins to semen freezability has been reported in several species, suggesting these proteins as genetic markers. The aim of this study was to evaluate the relationship between cysteine-rich secretory protein-3 (CRISP-3) and some of its single-nucleotide polymorphisms (SNPs) with post-thawing semen quality in stallions. DNA was obtained from 100 stallions, regions of interest were amplified by polymerase chain reaction and sequenced. Evaluated SNPs within the equine CRISP-3 gene were CRISP3c...
August 31, 2017: Reproduction, Fertility, and Development
Lindsey B Amerine, Stephen F Eckel, Robert P Granko, Chad Hatfield, Scott Savage, Elizabeth Forshay, Brett Crisp, Kayla Waldron, Henry Champ Burgess, Rowell Daniels
No abstract text is available yet for this article.
September 1, 2017: American Journal of Health-system Pharmacy: AJHP
Minghui Wang, Yonghai Sun, Jumin Hou, Xia Wang, Xue Bai, Chunhui Wu, Libo Yu, Jie Yang
The cloud model is a typical model which transforms the qualitative concept into the quantitative description. The cloud model has been used less extensively in texture studies before. The purpose of this study was to apply the cloud model in food crispness comparison. The acoustic signals of carrots, white radishes, potatoes, Fuji apples and crystal pears were recorded during compression. And three time-domain signal characteristics were extracted, including sound intensity, maximum short-time frame energy and waveform index...
August 23, 2017: Journal of Texture Studies
(no author information available yet)
1 A former health minister has been promoting a new global campaign to boost the profile of the nursing profession. Speaking exclusively to Nursing Standard, Lord Nigel Crisp says Nursing Now! is due to begin in January. Read more:
August 23, 2017: Nursing Standard
Charles Ricardo Lopes, Marcelo Saldanha Aoki, Alex Harley Crisp, Renê Scarpari de Mattos, Miguel Alves Lins, Gustavo Ribeiro da Mota, Brad Jon Schoenfeld, Paulo Henrique Marchetti
The purpose of this study was to evaluate the impact of moderate-load (10 RM) and low-load (20 RM) resistance training schemes on maximal strength and body composition. Sixteen resistance-trained men were randomly assigned to 1 of 2 groups: a moderate-load group (n = 8) or a low-load group (n = 8). The resistance training schemes consisted of 8 exercises performed 4 times per week for 6 weeks. In order to equate the number of repetitions performed by each group, the moderate load group performed 6 sets of 10 RM, while the low load group performed 3 sets of 20 RM...
September 2017: Journal of Human Kinetics
Xiuyun Jiang, Y David Seo, Jae Hyuck Chang, Andrew Coveler, Eslam N Nigjeh, Sheng Pan, Florencia Jalikis, Raymond S Yeung, Ian N Crispe, Venu G Pillarisetty
Pancreatic ductal adenocarcinoma (PDA) remains a deadly disease that is rarely cured, despite many recent successes with immunotherapy for other malignancies. As the human disease is heavily infiltrated by effector T cells, we postulated that accurately modeling the PDA immune microenvironment would allow us to study mechanisms of immunosuppression that could be overcome for therapeutic benefit. Using viable precision-cut slices from fresh PDA, we developed an organotypic culture system for this purpose. We confirmed that cultured slices maintain their baseline morphology, surface area, and microenvironment after at least 6 d in culture, and demonstrated slice survival by MTT assay and by immunohistochemistry staining with Ki-67 and cleaved-Caspase-3 antibodies...
2017: Oncoimmunology
Shuxin Han, Yanling Gao, Guoquan Fan, Wei Zhang, Cailing Qiu, Shu Zhang, Yanju Bai, Junhua Zhang, Carl Spetz
This study reports the findings of a distinct Potato virus Y (PVY) isolate found in Northeast China. One hundred and ten samples (leaves and tubers) were collected from potato plants showing mosaic symptoms around the city of Harbin in Heilongjiang province of China. The collected tubers were planted and let to grow in a greenhouse. New potato plants generated from these tubers showed similar symptoms, except for one plant. Subsequent serological analyses revealed PVY as the causing agent of the disease. A novel PVY isolate (referred to as HLJ-C-44 in this study) was isolated from this sample showing unique mild mosaic and crisped leaf margin symptoms...
August 2017: Plant Pathology Journal
Francesco Esposito, Antonio Nardone, Evelina Fasano, Maria Triassi, Teresa Cirillo
Potato crisps, corn-based extruded snacks and other savoury snacks are very popular products especially among younger generations. These products could be a potential source of acrylamide (AA), a toxic compound which could develop during frying and baking processes. The purpose of this study was the assessment of the dietary intake to AA across six groups of consumers divided according to age through the consumption of potato crisps and other snacks, in order to eventually evaluate the margin of exposure (MOE) related to neurotoxic and carcinogenic critical endpoints...
August 12, 2017: Food and Chemical Toxicology
Alicia Enrico, Yesica Bestach, Maria Gabriela Flores, Jorge Arbelbide, Camila Serale, Viviana Novoa, Renée Crisp, María Marta Rivas, Irene Larripa, Carolina Belli
BACKGROUND: A large group of patients with myelodysplastic syndromes (MDS) will die of causes intrinsic to bone marrow failure. One third of patients will develop acute myeloid leukemia (AML), which is associated with an extremely poor outcome and a short survival. Our objectives were to analyze the prognostic variables and scoring systems in the attempt to determine the influence of progression on the overall survival of MDS patients. PATIENTS AND METHODS: We performed a retrospective analysis of 831 MDS patients, including those from the Argentine Registry...
June 23, 2017: Clinical Lymphoma, Myeloma & Leukemia
Chao Chen, Alina Zare, Huy N Trinh, Gbenga O Omotara, J Tory Cobb, Timotius A Lagaunne
Topic models (e.g., pLSA, LDA, sLDA) have been widely used for segmenting imagery. However, these models are confined to crisp segmentation, forcing a visual word (i.e., an image patch) to belong to one and only one topic. Yet, there are many images in which some regions cannot be assigned a crisp categorical label (e.g., transition regions between a foggy sky and the ground or between sand and water at a beach). In these cases, a visual word is best represented with partial memberships across multiple topics...
August 4, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Radika Soysa, Xia Wu, I Nicholas Crispe
Dendritic cells (DCs) play a key role in innate immune responses, and are also the most effective cells for the activation of T cell immunity. They acquire antigen and process it, then display in on the cell surface bound in a non-covalent complex with HLA molecules of class I (HLA-A, B, C) and class II (HLA-DR). These cells are subdivided into three main subsets, two called myeloid or classical DCs of types 1 and 2, and one called plasmacytoid. The myeloid DCs process and present antigen, while the plasmacytoid DCs also strongly respond to viral signals by secreting Type 1 Interferon...
July 28, 2017: Liver Transplantation
Elisabeth H M Temme, Marieke A H Hendriksen, Ivon E J Milder, Ido B Toxopeus, Susanne Westenbrink, Henny A M Brants, Daphne L van der A
BACKGROUND AND OBJECTIVES: High salt intake increases blood pressure and thereby the risk of chronic diseases. Food reformulation (or food product improvement) may lower the dietary intake of salt. This study describes the changes in salt contents of foods in the Dutch market over a five-year period (2011-2016) and differences in estimated salt intake over a 10-year period (2006-2015). METHODS: To assess the salt contents of foods; we obtained recent data from chemical analyses and from food labels...
July 22, 2017: Nutrients
Otto Chan, Ben Havard, Sarah Morton, Mel Pritchard, Nicola Maffulli, Tom Crisp, Nat Padhiar, Jeremy David Perry, John King, Dylan Morrissey
BACKGROUND: The intra-tendinous tear is a new pathology that is defined as a discontinuity of fibres situated entirely within the tendon. Prolotherapy involves injecting an irritant, such as hyperosmolar dextrose, to stimulate a tissue healing response and ultimately reduce pain. METHODS: 43 consecutive patients diagnosed with an intra-tendinous tear were included (27 males: 16 females, mean (SD) age 41 (11.3). Patients were injected with 0.4ml-1.5ml (mean 0.8ml) of 50% dextrose and 0...
January 2017: Muscles, Ligaments and Tendons Journal
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