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Statins linked to Diabetes

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https://www.readbyqxmd.com/read/27900409/perspectives-and-challenges-of-antioxidant-therapy-for-atrial-fibrillation
#1
REVIEW
Iveta Gasparova, Peter Kubatka, Radka Opatrilova, Martin Caprnda, Slavomira Filipova, Luis Rodrigo, Leone Malan, Ioana Mozos, Miroslava Rabajdova, Vladimir Nosal, Nazarii Kobyliak, Vanda Valentova, Daniel Petrovic, Mariusz Adamek, Peter Kruzliak
Atrial fibrillation (AF) is the most common sustained arrhythmia associated with significant morbidity and mortality. The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. There is growing evidence that oxidative stress is involved in the pathogenesis of AF. Many known triggers of oxidative stress, such as age, diabetes, smoking, and inflammation, are linked with an increased risk of arrhythmia. Numerous preclinical studies and clinical trials reported the importance of antioxidant therapy in the prevention of AF, using vitamins C and E, polyunsaturated fatty acids, statins, or nitric oxide donors...
November 29, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27746733/atorvastatin-therapy-modulates-telomerase-activity-in-patients-free-of-atherosclerotic-cardiovascular-diseases
#2
Irina D Strazhesko, Olga N Tkacheva, Dariga U Akasheva, Ekaterina N Dudinskaya, Ekaterina V Plokhova, Valentina S Pykhtina, Anna S Kruglikova, Natalia V Kokshagina, Natalia V Sharashkina, Mikhail V Agaltsov, Daria A Kashtanova, Vladimir A Vygodin, Irina N Ozerova, Dmitry A Skvortsov, Daria Vasilkova, Sergey A Boytsov
Background: Telomerase activity (TA) is considered as the biomarker for cardiovascular aging and cardiovascular diseases (CVDs). Recent studies suggest a link between statins and telomere biology that may be explained by anti-inflammatory actions of statins and their positive effect on TA. Until now, this effect has not been investigated in prospective randomized studies. We hypothesized that 12 months of atorvastatin therapy increased TA in peripheral blood mononuclear cells. Methods: In a randomized, placebo-controlled study 100 hypercholesterolemic patients, aged 35-75 years, free of known CVDs and diabetes mellitus type 2 received 20 mg of atorvastatin daily or placebo for 12 months...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27712954/2016-canadian-cardiovascular-society-guidelines-for-the-management-of-dyslipidemia-for-the-prevention-of-cardiovascular-disease-in-the-adult
#3
Todd J Anderson, Jean Grégoire, Glen J Pearson, Arden R Barry, Patrick Couture, Martin Dawes, Gordon A Francis, Jacques Genest, Steven Grover, Milan Gupta, Robert A Hegele, David C Lau, Lawrence A Leiter, Eva Lonn, G B John Mancini, Ruth McPherson, Daniel Ngui, Paul Poirier, John L Sievenpiper, James A Stone, George Thanassoulis, Richard Ward
Since the publication of the 2012 guidelines new literature has emerged to inform decision-making. The 2016 guidelines primary panel selected a number of clinically relevant questions and has produced updated recommendations, on the basis of important new findings. In subjects with clinical atherosclerosis, abdominal aortic aneurysm, most subjects with diabetes or chronic kidney disease, and those with low-density lipoprotein cholesterol ≥ 5 mmol/L, statin therapy is recommended. For all others, there is an emphasis on risk assessment linked to lipid determination to optimize decision-making...
July 25, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27678041/medication-use-and-survival-in-diabetic-patients-with-kidney-cancer-a-population-based-cohort-study
#4
Madhur Nayan, Erin M Macdonald, David N Juurlink, Peter C Austin, Antonio Finelli, Girish S Kulkarni, Robert J Hamilton
Survival rates in kidney cancer have improved little over time, and diabetes may be an independent risk factor for poor survival in kidney cancer. We sought to determine whether medications with putative anti-neoplastic properties (statins, metformin and non-steroidal anti-inflammatory drugs (NSAIDs)) are associated with survival in diabetics with kidney cancer. We conducted a population-based cohort study utilizing linked healthcare databases in Ontario, Canada. Patients were aged 66 or older with newly diagnosed diabetes and a subsequent diagnosis of incident kidney cancer...
September 24, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27662221/cost-benefit-of-appointment-based-medication-synchronization-in-community-pharmacies
#5
Julie A Patterson, David A Holdford, Kunai Saxena
OBJECTIVES: To evaluate the cost-benefit of appointment-based medication synchronization (ABMS) offered in community pharmacies for patients taking chronic medications to prevent negative outcomes associated with hyperlipidemia, hypertension, and diabetes. STUDY DESIGN: Decision-tree analysis based on published literature and publicly available data. METHODS: Program benefits were based on linking published findings of improvements in medication adherence due to the implementation of an ABMS program to a claims-based study of disease-related medical costs associated with different levels of adherence...
September 2016: American Journal of Managed Care
https://www.readbyqxmd.com/read/27609708/-fibrates-therapy-rational-use-fenofibrate-2016-executive-summary
#6
Angel Brea, Jesús Millán, Juan F Ascaso, Mariano Blasco, Angel Díaz, Pedro González-Santos, Antonio Hernández-Mijares, Teresa Mantilla, Juan C Pedro-Botet, Xavier Pintó
To control lipid factors risk, beyond proper management of LDL cholesterol according to individual risk, detection and treatment of atherogenic dyslipidemia and abnormal levels of triglycerides or HDL cholesterol it should be considered for address a global cardiovascular protection, both in primary and secondary prevention. In this sense, these recommendations collect data on efficacy and safety about the combination statin with fibrates, often necessary for total control of dyslipidemia, particularly in patients with metabolic disorders such as diabetes mellitus, metabolic syndrome or visceral obesity...
September 5, 2016: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/27565724/atorvastatin-and-rosuvastatin-improve-physiological-parameters-and-alleviate-immune-dysfunction-in-metabolic-disorders
#7
Sungwon Lee, Youngjoo Lee, Jiyeon Kim, Jinho An, Kwanghee Kim, Heetae Lee, Hyunseok Kong, Youngcheon Song, Kyungjae Kim
This study was designed to characterize the potential therapeutic effects of two statin drugs commonly used to treat dyslipidemia in inflammation-linked metabolic disorders related to type 2 diabetes. Atorvastatin (10 mg/kg/day) and rosuvastatin (3 mg/kg/day) were administered to mice with diet-induced obesity (DIO). The statins lowered serum total and LDL cholesterol levels, and improved the atherogenic index and cardiac risk index. Furthermore, the drugs decreased fasting glucose levels, improved glucose tolerance, and decreased fat tissue weight and adipocyte size; this was accompanied by an overall body weight loss tendency...
September 23, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27525366/lower-and-higher-potency-statins-on-glycemic-control-in-type-2-diabetes-a-retrospective-cohort-study
#8
Gianluca Bardini, Stefano Giannini, Carlo Maria Rotella, Laura Pala, Barbara Cresci, Edoardo Mannucci
AIMS: Evidences showed a link between statins and new-onset diabetes and large clinical trials in type 2 diabetes (T2DM) suggested a mild glycemic progression in statin treated. Since this effect has not yet elucidated in real world, we investigated the effects of different statins on glycemia in T2DM clinic outpatients. METHODS: In a retrospective cohort study, we recorded at 6 and 12months modifications of fasting glucose (FPG), HbA1c, diabetes intensification therapy and target rate for HbA1c in 421 T2DM non-users and new statin users...
October 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27377891/a-metabolic-inhibitory-cocktail-for-grave-cancers-metformin-pioglitazone-and-lithium-combination-in-treatment-of-pancreatic-cancer-and-glioblastoma-multiforme
#9
REVIEW
İlhan Elmaci, Meric A Altinoz
Pancreatic cancer (PC) and glioblastoma multiforme (GBM) are among the human cancers with worst prognosis which require an urgent need for efficient therapies. Here, we propose to apply to treat both malignancies with a triple combination of drugs, which are already in use for different indications. Recent studies demonstrated a considerable link between risk of PC and diabetes. In experimental models, anti-diabetogenic agents suppress growth of PC, including metformin (M), pioglitazone (P) and lithium (L)...
October 2016: Biochemical Genetics
https://www.readbyqxmd.com/read/27353847/resection-of-hepatocellular-carcinoma-in-elderly-patients-and-the-role-of-energy-balance
#10
Marco Cannistrà, Raffaele Grande, Michele Ruggiero, Matteo Novello, Alessandra Zullo, Elisabetta Bonaiuto, Sebastiano Vaccarisi, Giuseppe Cavallari, Raffaele Serra, Bruno Nardo
INTRODUCTION: Progressive functional impairment with age has a significant impact on perioperative risk management. Chronic liver diseases induce a strong oxidative stress; in the elderly, in particular, impaired elimination of free radicals leads to insufficient DNA repair. The events associated with a weak response to growth factors after hepatectomy leads to a decline in liver regeneration. Hypercholesterolemia is highly prevalent in the elderly, which may alter the coenzyme Q10 (CoQ) levels and in turn the cellular energy balance...
September 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27341997/the-effects-of-metformin-and-simvastatin-on-the-growth-of-lncap-and-rwpe-1-prostate-epithelial-cell-lines
#11
Pasi Pennanen, Heimo Syvälä, Merja Bläuer, Kimmo Savinainen, Timo Ylikomi, Teuvo L J Tammela, Teemu J Murtola
The anti-diabetic drug metformin and cholesterol-lowering statins inhibit prostate cancer cell growth in vitro and have been linked with lowered risk of prostate cancer in epidemiological studies. We evaluated the effects of these drugs on cancerous and non-cancerous prostate epithelial cell lines. Cancer (LNCaP) and normal (RWPE-1) prostate epithelial cell lines were treated with pharmacologic concentrations of metformin and simvastatin alone and in combinations. Relative changes in cell number were measured with crystal violet staining method...
October 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27251151/medicines-and-vegetable-oils-as-hidden-causes-of-cardiovascular-disease-and-diabetes
#12
Harumi Okuyama, Peter H Langsjoen, Naoki Ohara, Yoko Hashimoto, Tomohito Hamazaki, Satoshi Yoshida, Tetsuyuki Kobayashi, Alena M Langsjoen
BACKGROUND: Positive associations have been observed between cardiovascular disease (CVD) and type 2 diabetes mellitus (DM), but their causal relationship has not been clarified. Nevertheless, guidelines from relevant medical societies recommend using cholesterol lowering medication (statin) for both types of patients. Medicines with several different action mechanisms have been developed, and the effectiveness of different lifestyle modifications has been studied extensively for the prevention of DM, which was successful in improving clinical marker status in relatively short-term treatments, but none have been shown to be effective in improving long-term outcomes (mortality from CVD and all causes)...
2016: Pharmacology
https://www.readbyqxmd.com/read/27236090/relationships-between-2-year-survival-costs-and-outcomes-following-carotid-endarterectomy-in-asymptomatic-patients-in-the-vascular-quality-initiative
#13
Jessica B Wallaert, Karina A Newhall, Bjoern D Suckow, Benjamin S Brooke, Min Zhang, Adrienne E Farber, Donald Likosky, Philip P Goodney
BACKGROUND: Carotid endarterectomy (CEA) for asymptomatic patients with limited life expectancy may not be beneficial or cost-effective. The purpose of this study was to examine relationships among survival, outcomes, and costs within 2 years following CEA among asymptomatic patients. METHODS: Prospectively collected data from 3097 patients undergoing CEA for asymptomatic disease from Vascular Quality Initiative VQI registry were linked to Medicare. Models were used to identify predictors of 2-year mortality following CEA...
August 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27212184/renoprotective-effect-of-atorvastatin-on-stz-diabetic-rats-through-inhibiting-inflammatory-factors-expression-in-diabetic-rat
#14
D Liao, Y-Q Liu, L-Y Xiong, L Zhang
OBJECTIVE: Though increasing evidences showed that statins had potential benefits to diabetic kidney disease (DKD), its mechanism has not been completely elucidated yet. The aim of this study was to investigate the renoprotective effects of atorvastatin on DKD. MATERIALS AND METHODS: Kidney injury was induced by streptozotocin (STZ) in rats. STZ-diabetic rats were treated with atorvastatin (10 mg/kg/d) for consecutive 8 weeks. Renal functional and morphological changes were evaluated by clinical biochemistry and histological examination...
May 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27199064/statin-associated-side-effects
#15
REVIEW
Paul D Thompson, Gregory Panza, Amanda Zaleski, Beth Taylor
Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins are well tolerated, but associated with various statin-associated symptoms (SAS), including statin-associated muscle symptoms (SAMS), diabetes mellitus (DM), and central nervous system complaints. These are "statin-associated symptoms" because they are rare in clinical trials, making their causative relationship to statins unclear. SAS are, nevertheless, important because they prompt dose reduction or discontinuation of these life-saving mediations...
May 24, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27133274/-diabetic-dyslipidaemia-and-the-atherosclerosis
#16
REVIEW
László Márk, Győző Dani
The incidence and the public health importance of diabetes mellitus are growing continuously. Despite the improvement observed in recent years, the leading cause of morbidity and mortality of diabetics are cardiovascular diseases. The diagnosis of diabetes mellitus constitutes such a high risk as the known presence of vascular disease. Diabetic dyslipidaemia is characterised by high fasting and postprandial triglyceride levels, low HDL level, and slightly elevated LDL-cholesterol with domination of atherogenic small dense LDL...
May 8, 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/26961236/-pcsk9-inhibitors-in-hypercholesterolemia-new-hope-for-patients-with-diabetes-mellitus
#17
K G Parhofer
The interrelation between glucose and lipid metabolism is complex and comprises many aspects. In this context diabetic dyslipidemia is of utmost importance as it represents the crucial link between diabetes and cardiovascular disease. Although hypertriglyceridemia is usually the most prominent lipid abnormality in diabetic patients, reduction of low-density lipoprotein (LDL) cholesterol is the most important strategy to prevent cardiovascular disease. Statin trials and more recently the combination of statin with ezetimibe clearly showed that diabetic patients benefit from low LDL cholesterol levels...
May 2016: Herz
https://www.readbyqxmd.com/read/26959703/genetic-insights-into-statin-associated-diabetes-risk
#18
Daniel I Swerdlow, David Preiss
PURPOSE OF REVIEW: Meta-analyses of major statin trials have suggested that statin therapy modestly increases the risk of developing diabetes. However, the quality of the data on which these findings are based is not without weaknesses and it has also been unclear whether this effect, if true, is an on-target or off-target effect of statins. RECENT FINDINGS: In a major Mendelian randomization study of variants in the HMGCR gene, which encodes the protein through which statins exert their effect, two polymorphisms associated with lower LDL-cholesterol were also associated with higher weight, higher waist circumference, higher glucose and higher diabetes risk...
April 2016: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/26954681/statin-safety-in-chinese-a-population-based-study-of-older-adults
#19
Daniel Q Li, Richard B Kim, Eric McArthur, Jamie L Fleet, Robert A Hegele, Baiju R Shah, Matthew A Weir, Amber O Molnar, Stephanie Dixon, Jack V Tu, Sonia Anand, Amit X Garg
BACKGROUND: Compared to Caucasians, Chinese achieve a higher blood concentration of statin for a given dose. It remains unknown whether this translates to increased risk of serious statin-associated adverse events amongst Chinese patients. METHODS: We conducted a population-based retrospective cohort study of older adults (mean age, 74 years) newly prescribed a statin in Ontario, Canada between 2002 and 2013, where 19,033 Chinese (assessed through a validated surname algorithm) were matched (1:3) by propensity score to 57,099 non-Chinese...
2016: PloS One
https://www.readbyqxmd.com/read/26954655/statin-associated-diabetes-mellitus-review-and-clinical-guide
#20
REVIEW
James M Backes, Matthew D Kostoff, Cheryl A Gibson, Janelle F Ruisinger
A small but significant link between new-onset diabetes mellitus (NOD) and statin therapy was noted with rosuvastatin users in the Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin study. Since then multiple analyses have further confirmed this association, with most studies demonstrating a modest increase in NOD with statin therapy, especially among individuals with risk factors for developing diabetes mellitus. More recent observational analyses suggest a stronger correlation between statin use and NOD, however...
March 2016: Southern Medical Journal
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