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https://www.readbyqxmd.com/read/28538503/complete-resection-of-pancreatoblastoma-with-portal-vein-obstruction-after-high-dose-chemotherapy-a-case-report
#1
Souji Ibuka, Shuichiro Uehara, Takehisa Ueno, Takaharu Oue, Takako Miyamura, Yoshiko Hashii, Hiroomi Okuyama
BACKGROUND: As no standard chemotherapy exists for pancreatoblastoma (PB), surgical resection is the most effective way of achieving complete remission. CASE REPORT: A 3-year-old girl with PB causing portal vein obstruction was referred to our hospital. Because of the portal vein involvement, she initially received 5 cycles of preoperative chemotherapy after biopsy, consisting of cyclophosphamide, vincristine, pirarubicin, and cisplatin. After chemotherapy, she underwent distal pancreatectomy, and the tumor was resected completely...
May 22, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28537412/-solid-pseudopapillary-neoplasms-of-the-pancreas
#2
J Tesaříková, M Loveček, Č Neoral, K Vomáčková, L Bébarová, P Skalický
INTRODUCTION: Solid pseudopapillary neoplasm (SPN) is a very rare neoplasm that occurs in girls and young women in 90% of cases; the range is 779 years of age, and the median is 28 years of age. This tumour was first described by Virginia Frantz in 1959 as a papillary cystic tumour of the pancreas. METHODS: The aim of this retrospective study was to analyse the incidence of SPN in all patients with a pancreatic tumour operated at the 1st Dept. of Surgery, University Hospital Olomouc between years 2006 and 2015...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28529742/intraductal-tubulopapillary-neoplasm-accompanied-by-invasive-carcinoma-of-the-pancreas-a-case-report-and-review-of-the-literature
#3
Li Niu, Zhigao Xu, Huan Liu, Hong Cao, Guifang Yang
Intraductal tubulopapillary neoplasms (ITPNs) are rare pancreatic neoplasms accounting for ~0.4% of pancreatic tumors. However, their clinicopathological characteristics have not been clearly determined and the number of available clinical studies on this type of tumor is limited at present. Due to the rare incidence of ITPN, diagnosis is often delayed. We herein present a unique case of a 38-year-old man who was diagnosed with ITPN accompanied with invasive carcinoma of the pancreas and underwent total pancreatectomy...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28522787/surgical-treatment-of-pancreatic-cystic-tumors
#4
Beata Jabłońska, Łukasz Braszczok, Weronika Szczęsny-Karczewska, Beata Dubiel-Braszczok, Paweł Lampe
The aim of this study was to assess short-term outcomes of surgical treatment of pancreatic cystic tumors (PCTs). MATERIAL AND METHODS: We retrospectively reviewed medical records of 46 patients (31 women and 15 men) who had undergone surgery for pancreatic cystic tumors in our department. RESULTS: Pancreatic cystic tumors were located within the pancreatic head (21), body (11), tail (13), and whole pancreas (1). The following surgical procedures were performed: pancreatoduodenectomy (20), central pancreatectomy (9), distal pancreatectomy (3), distal pancreatectomy with splenectomy (3), distal extended pancreatectomy with splenectomy (2), total pancreatectomy (1), duodenum preserving pancreatic head resection (1), local tumor resection (4), and other procedures (2)...
February 28, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28522785/infeasibility-of-endoscopic-transmural-drainage-due-to-pancreatic-pseudocyst-wall-calcifications-case-report
#5
Andrzej Krajewski, Gustaw Lech, Marcin Makiewicz, Andrzej Kluciński, Monika Wojtasik, Sławomir Kozieł, Maciej Słodkowski
Postinflammatory pancreatic pseudocysts are one of the most common complications of acute pancreatitis. In most cases, pseudocysts self-absorb in the course of treatment of pancreatitis. In some patients, pancreatic pseudocysts are symptomatic and cause pain, problems with gastrointestinal transit, and other complications. In such cases, drainage or resection should be performed. Among the invasive methods, mini invasive procedures like endoscopic transmural drainage through the wall of the stomach or duodenum play an important role...
February 28, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28522378/a-comparative-study-of-risk-factors-for-pancreatic-fistula-after-pancreatoduodenectomy-or-distal-pancreatectomy
#6
James M Halle-Smith, Eduardo Vinuela, Rachel M Brown, James Hodson, Zergham Zia, Simon R Bramhall, Ravi Marudanayagam, Robert P Sutcliffe, Darius F Mirza, Paolo Muiesan, John Isaac, Keith J Roberts
BACKGROUND: Evidence associates various biometric and histological variables such as steatosis and absence of fibrosis as risk factors for post-operative pancreatic fistula (POPF) after pancreatoduodenectomy (PD). Following distal pancreatectomy (DP), the association between these factors and POPF is less clear. This study of patients, drawn from the same background population, undergoing PD or DP at a single centre is a comparative study of the risk factors for POPF after these two operations...
May 15, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28520652/a-systematic-review-and-meta-analysis-of-laparoscopic-and-open-distal-pancreatectomy-of-nonductal-adenocarcinomatous-pancreatic-tumor-ndacpt-in-the-pancreatic-body-and-tail
#7
Xiaojiang Yi, Sile Chen, Wei Wang, Liaonan Zou, Dechang Diao, Yansheng Zheng, Yaobin He, Hongming Li, Lijie Luo, Wenjun Xiong, Jin Wan
BACKGROUND: Currently, laparoscopic distal pancreatectomy is regarded as a safe and effective surgical approach for lesions in the body and tail of the pancreas. This review examined the evidence from published data of comparative studies of laparoscopic versus open distal pancreatectomy of nonductal adenocarcinomatous pancreatic tumor in pancreatic body and tail. METHODS: A systematic review of the studies comparing laparoscopic and open distal pancreatectomy was conducted...
May 17, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28514000/long-term-outcomes-and-recurrence-patterns-of-standard-versus-extended-pancreatectomy-for-pancreatic-head-cancer-a-multicenter-prospective-randomized-controlled-study
#8
Jin-Young Jang, Jae Seung Kang, Youngmin Han, Jin Seok Heo, Seong Ho Choi, Dong Wook Choi, Sang Jae Park, Sung-Sik Han, Dong Sup Yoon, Joon Seong Park, Hee Chul Yu, Koo Jeong Kang, Sang Geol Kim, Hongeun Lee, Wooil Kwon, Yoo-Seok Yoon, Ho-Seong Han, Sun-Whe Kim
BACKGROUND/PURPOSE: Our previous randomized controlled trial revealed no difference in 2-year overall survival (OS) between extended and standard resection for pancreatic adenocarcinoma. The present study evaluated the 5-year OS and recurrence patterns according to the extent of pancreatectomy. METHODS: Between 2006 and 2009, 169 consecutive patients were prospectively enrolled and randomized to standard (n=83) or extended resection (n=86) groups to compare 5-year OS rate, long-term recurrence patterns and factors associated with long-term survival...
May 17, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28512677/heterogeneity-of-proliferative-markers-in-pancreatic-%C3%AE-cells-of-patients-with-severe-hypoglycemia-following-roux-en-y-gastric-bypass
#9
Mary-Elizabeth Patti, Allison B Goldfine, Jiang Hu, Dag Hoem, Anders Molven, Jeffrey Goldsmith, Wayne H Schwesinger, Stefano La Rosa, Franco Folli, Rohit N Kulkarni
AIMS: Severe postprandial hypoglycemia with neuroglycopenia is an increasingly recognized, debilitating complication of Roux-en-Y gastric bypass (RYGB) surgery. Increased secretion of insulin and incretin hormones is implicated in its pathogenesis. Histopathologic examination of pancreas has demonstrated increased islet size and/or nuclear diameter in post-RYGB patients who underwent pancreatectomy for severe refractory hypoglycemia with neuroglycopenia (RYGB + NG). We aimed to determine whether β-cell proliferation or apoptosis is altered in RYGB + NG...
May 17, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28512414/an-intra-abdominal-desmoid-tumor-embedded-in-the-pancreas-preoperatively-diagnosed-as-an-extragastric-growing-gastrointestinal-stromal-tumor
#10
Mari Mizuno, Yoshiaki Kawaguchi, Aya Kawanishi, Yohei Kawashima, Atsuko Maruno, Masami Ogawa, Mifuji Tomioku, Daisuke Furukawa, Kazuhito Nabeshima, Kenji Nakamura, Kenichi Hirabayashi, Tetsuya Mine
A 45-year-old woman was found to have a pancreatic tumor by abdominal ultrasound performed for a medical check-up. Abdominal contrast-enhanced computed tomography showed a hypovascular tumor measuring 30 mm in diameter in the pancreatic tail. Endoscopic ultrasound-guided fine needle aspiration was performed. An extragastric growing gastrointestinal stromal tumor was thereby diagnosed preoperatively, and surgical resection was planned. Laparoscopic surgery was attempted but conversion to open surgery was necessitated by extensive adhesions, and distal pancreatectomy, splenectomy, and partial gastrectomy were performed...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28510280/modelling-the-iatrogenic-pancreatic-cancer-risk-after-islet-autotransplantation-in-mouse
#11
E Dugnani, V Pasquale, D Liberati, A Citro, E Cantarelli, S Pellegrini, P Marra, T Canu, G Balzano, M Scavini, A Esposito, C Doglioni, L Piemonti
Iatrogenic pancreatic cancer metastasis after islet infusion is a potential risk of islet autotransplantation performed after pancreatectomy. To model this risk islets and/or pancreatic exocrine clusters obtained from a genetically engineered mouse model for pancreatic ductal adenocarcinoma (the LSL-Kras(G12D/+) ;LSL-Trp53(R172H/+) ;Pdx-1-Cre, termed KPC mouse) were transplanted via the portal vein in syngeneic wild type (WT) severely diabetic recipients in the following treatment groups: group A (n=11) received KPC exocrine clusters in volume equal to 250 equivalent islets (IEQs); group B (n=12) received 250 WT IEQs mixed with KPC exocrine clusters (1:1 volume ratio); group C (n=5) received 250 KPC IEQs and group D (n=7) received 250 wild type IEQs...
May 16, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28505401/the-influence-of-a-composite-hospital-volume-on-outcomes-for-gastric-cancer-surgery-a-dutch-population-based-study
#12
Linde A D Busweiler, Johan L Dikken, Daniel Henneman, Mark I van Berge Henegouwen, Vincent K Y Ho, Rob A E M Tollenaar, Michel W J M Wouters, Johanna W van Sandick
BACKGROUND: Volume-outcome associations for complex surgical procedures have motivated centralization of care worldwide. The aim of this study was to investigate the association between overall hospital experience with complex upper gastrointestinal (GI) cancer resections and outcomes after gastric cancer surgery. METHODS: Data on all patients (n = 4837) who underwent a resection for non metastatic invasive gastric cancer between 2005 and 2014 were obtained from the Netherlands Cancer Registry (NCR)...
May 15, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28504112/potential-impact-of-a-volume-pledge-on-spatial-access-a-population-level-analysis-of-patients-undergoing-pancreatectomy
#13
Zhi Ven Fong, Andrew P Loehrer, Carlos Fernández-Del Castillo, Yanik J Bababekov, Ginger Jin, Cristina R Ferrone, Andrew L Warshaw, Lara N Traeger, Matthew M Hutter, Keith D Lillemoe, David C Chang
BACKGROUND: A minimum-volume policy restricting hospitals not meeting the threshold from performing complex operation may increase travel burden and decrease spatial access to operation. We aim to identify vulnerable populations that would be sensitive to an added travel burden. METHODS: We performed a retrospective analysis of the database of the California Office of Statewide Health Planning and Development for patients undergoing pancreatectomy from 2005 to 2014...
May 11, 2017: Surgery
https://www.readbyqxmd.com/read/28503843/the-volume-cost-and-outcomes-of-pancreatic-resection-in-a-regional-centre-in-new-zealand
#14
Neil Wylie, Phillip Hider, Delwyn Armstrong, Sanket Srinivasa, Michael Rodgers, Anna Brown, Jonathan Koea
BACKGROUND: The frequency, costs and outcome of pancreatic resection (both pancreaticoduodenectomy and distal pancreatectomy) were reviewed in our own institution and correlated with regional population growth as well as national resection rates and locations. METHODS: Demographic, pathological and outcome data on pancreaticoduodenectomy and distal pancreatectomy were obtained from a prospectively maintained database for the years 2005-2009 and 2010-2014. During this period, the catchment population grew from 460 000 to 567 000...
May 14, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28503258/feasibility-of-pancreatectomy-following-high-dose-proton-therapy-for-unresectable-pancreatic-cancer
#15
Kathryn E Hitchcock, R Charles Nichols, Christopher G Morris, Debashish Bose, Steven J Hughes, John A Stauffer, Scott A Celinski, Elizabeth A Johnson, Robert A Zaiden, Nancy P Mendenhall, Michael S Rutenberg
AIM: To review surgical outcomes for patients undergoing pancreatectomy after proton therapy with concomitant capecitabine for initially unresectable pancreatic adenocarcinoma. METHODS: From April 2010 to September 2013, 15 patients with initially unresectable pancreatic cancer were treated with proton therapy with concomitant capecitabine at 1000 mg orally twice daily. All patients received 59.40 Gy (RBE) to the gross disease and 1 patient received 50.40 Gy (RBE) to high-risk nodal targets...
April 27, 2017: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28495434/patterns-of-recurrence-and-long-term-outcomes-in-patients-who-underwent-pancreatectomy-for-intraductal-papillary-mucinous-neoplasms-with-high-grade-dysplasia-implications-for-surveillance-and-future-management-guidelines
#16
Aaron U Blackham, Matthew P Doepker, Barbara A Centeno, Gregory Springett, Jose M Pimiento, Mokenge Malafa, Pamela J Hodul
BACKGROUND: While intraductal papillary mucinous neoplasms (IPMNs) with high-grade dysplasia (HGD) are thought to represent non-invasive, high-risk lesions, its natural history following resection is unknown. METHODS: A retrospective review of HGD-IPMN patients (1999-2015) was performed. Recurrence patterns and clinical outcomes following pancreatectomy were analyzed and the indications for surgery were explored based on current guidelines. RESULTS: HGD was diagnosed in 100 of 314 patients (32%) following pancreatectomy for IPMN...
May 8, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28493165/minimally-invasive-distal-pancreatectomy-greatest-benefit-for-the-frail
#17
Ioannis T Konstantinidis, Aaron Lewis, Byrne Lee, Susanne G Warner, Yanghee Woo, Gagandeep Singh, Yuman Fong, Laleh G Melstrom
OBJECTIVE: The benefits of minimally invasive distal pancreatectomy (MIDP) over open surgery continue to be investigated. Frailty is a known predictor of postoperative outcome. We hypothesized that the benefit of minimally invasive distal pancreatectomy is the greatest for the frailest of patients. METHODS: Data from the pancreas-targeted National Surgical Quality Improvement Program (NSQIP) database for 2014 were reviewed. A modified frailty index (mFI) with 11 preoperative variables previously validated for use in NSQIP was used to determine the correlation between frailty and postoperative outcomes, including Clavien grade IV complications...
May 10, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28482873/clinical-impact-of-duodenal-pancreatic-heterotopia-is-there-a-need-for-surgical-treatment
#18
Alexander Betzler, Soeren T Mees, Josefine Pump, Sebastian Schölch, Carolin Zimmermann, Daniela E Aust, Jürgen Weitz, Thilo Welsch, Marius Distler
BACKGROUND: Pancreatic heterotopia (PH) is defined as ectopic pancreatic tissue outside the normal pancreas and its vasculature and duct system. Most frequently, PH is detected incidentally by histopathological examination. The aim of the present study was to analyze a large single-center series of duodenal PH with respect to the clinical presentation. METHODS: A prospective pancreatic database was retrospectively analyzed for cases of PH of the duodenum. All pancreatic and duodenal resections performed between January 2000 and October 2015 were included and screened for histopathologically proven duodenal PH...
May 8, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28480620/management-of-recurrent-bleeding-after-pancreatoduodenectomy
#19
Ralph F Staerkle, Justin S Gundara, Thomas J Hugh, Richard Maher, Brendan Steinfort, Jaswinder S Samra
BACKGROUND: Re-bleeding after management of a first haemorrhage following pancreatic surgery is an ever-present danger and often presents diagnostic and management dilemmas. METHODS: All cases of post-pancreatectomy haemorrhage (PPH) following pancreatoduodenectomy were identified from a tertiary referral, clinical database (April 2004-April 2013). Only those suffering a second re-bleeding episode were included in the final case notes review. RESULTS: A total of 301 patients underwent pancreatoduodenectomy during the study period (most common indication: pancreatic adenocarcinoma; 49...
May 8, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28477012/minimally-invasive-distal-pancreatectomy-for-pnets-laparoscopic-or-robotic-approach
#20
Jiaqiang Zhang, Jiabin Jin, Shi Chen, Jiangning Gu, Yi Zhu, Kai Qin, Qian Zhan, Dongfeng Cheng, Hao Chen, Xiaxing Deng, Baiyong Shen, Chenghong Peng
BACKGROUND: The most effective and radical treatment for pancreatic neuroendocrine tumors (PNETs) is surgical resection. Minimally invasive surgery has been increasingly used in pancreatectomy. Initial results in robotic distal pancreatectomy (RDP) have been encouraging. Nonetheless, data comparing outcomes of RDP with those of laparoscopic distal pancreatectomy (LDP) in treating PNETs are rare. The aim of this study was to compare the safety and efficacy of RDP and LDP for PNETs. METHODS: From September 2010 to January 2017, operative parameters and perioperative outcomes in an initial experience with 43 consecutive patients undergoing RDP were collected and compared with those in 31 patients undergoing LDP...
May 16, 2017: Oncotarget
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